CN105126037B - A kind of ointment for treating bone fracture and injury of the extract containing natural component and preparation method thereof - Google Patents
A kind of ointment for treating bone fracture and injury of the extract containing natural component and preparation method thereof Download PDFInfo
- Publication number
- CN105126037B CN105126037B CN201510658027.4A CN201510658027A CN105126037B CN 105126037 B CN105126037 B CN 105126037B CN 201510658027 A CN201510658027 A CN 201510658027A CN 105126037 B CN105126037 B CN 105126037B
- Authority
- CN
- China
- Prior art keywords
- ethyl alcohol
- extracting solution
- extract
- oil
- time plus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses ointment for treating bone fracture and injury of a kind of extract containing natural component and preparation method thereof, including：Fat of Oromaius norvaehollandeae, oil of zedoary turmeric, badger seed oil, aloe, borage oil, rose hip oil, wheat source emulsifier MONTANOV 82, does not have medicament extracting solution and own extracting solution, dipsacus root extracting solution, Rhizoma Et Radix Notopterygii extracting solution, Cortex Acanthopanacis Radicis extracting solution, Carbopol 941, ice crystal forming agent, glycerine, 0.2% ethylparaben alcoholic solution etc. at turpentine oil.Compared with existing product, have pharmacological property mild, it is safe, the features such as Small side effects, promotes skin health growth using the active material in natural drug, restores the normal barrier function of skin itself, active ingredient is mostly natural drug, has apparent therapeutic effect to traumatic injury, promoting blood circulation.In addition there is the effect of calm antipruritic, elimination is red and swollen, soothes the skin surface layer, and alleviation skin scabs, there is the effect of being relieved traumatic injury situation.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of ointment for treating bone fracture and injury of the extract containing natural component and its preparation
Method.
Background technology
Traumatic injury be local soft tissue because weapons, fall flutter, the sudden strain of a muscle, the reasons such as scratch lead to the diseases such as swollen, pain, bleeding of becoming silted up
A kind of illness of shape.Traumatic injury is common disease, frequently-occurring disease, and scratch is often met in people's daily routines, and bleeding is presented, becomes silted up
The swollen symptoms such as livid purple, here it is traumatic injuries.It is different according to the severity of damage, it may also have the performances such as fracture, dislocation.
Many people occurred abrading the livid purple experience of bleeding, extravasated blood, and especially summer, hot weather, people wear clothing
Object is frivolous and less, along with present people like out on tours or open air is ascended a height, tumble injury, even more common occurrence of damaging more.
So in general first-aid kit for domestic use, drug for traumatic injuries is all indispensable.Common drug has oral drugs therapy：
Temporarily analgesic.The disadvantage is that the injury to kidney is very big, it is particularly unsuitable for the sick and weak middle-aged and the old.Also there is general externally applied drug
Water, medicine oil therapy, disadvantage of this method on anti-inflammatory analgetic are：It is typically only capable to eliminate surface swelling and pain, it is soft deep layer can not to be repaired
Tissue damage, curative effect have certain limitation.
So while developing a kind of elimination surface swelling and pain, moreover it is possible to repair damaged joints and underlying soft tissue position；Together
When can also enhance body cell vigor, improve human body physiological defense ability, not only take stopgap measures but also effect a permanent cure and human body will not be caused to stimulate,
Not by oral administration, the ointment for treating bone fracture and injury for not damaging liver kidney is necessary.
Invention content
In order to solve the above technical problems, the object of the present invention is to provide a kind of bruise of extract containing natural component damages
Vulnerary cream can eliminate surface swelling and pain, moreover it is possible to repair damaged joints and underlying soft tissue position.
The present invention also provides a kind of preparation methods of the ointment for treating bone fracture and injury of extract containing natural component, are prepared
Ointment for treating bone fracture and injury, which takes stopgap measures, to effect a permanent cure, and effect is good.
The ointment for treating bone fracture and injury of a kind of extract containing natural component provided by the invention, including following raw material：
Described and own extracting solution is to be prepared by the following method：
It weighs and oneself is appropriate, be ground into coarse powder, 70% ethyl alcohol immersion 0.15-0.8h, heating and refluxing extraction 3 times, the 1st time
Add 8~18 times of 70% ethyl alcohol of amount, extract 0.5-2h, the 2nd time plus 8-15 times measure 70% ethyl alcohol, extract 0.5-1.5h, the 3rd time plus 8-
10 times of 70% ethyl alcohol of amount, extract 0.5-1.5h, filter every time, the decompression volume of merging filtrate, filtrate is concentrated into and own weight
4-7 times of g/ml, is filtered to obtain the final product.
The medicament extracting solution that do not have is to be prepared by the following method：
It is appropriate to weigh myrrh, is ground into coarse powder, with 95% ethyl alcohol impregnate 0.15-0.8h, heating and refluxing extraction 3 times, the 1st time
Add 10~20 times of 95% ethyl alcohol of amount, extract 0.5-2h, the 2nd time plus 8-15 times measure 95% ethyl alcohol, extract 0.5-1.5h, the 3rd time plus
8-10 times is measured 95% ethyl alcohol, is extracted 0.5-1.5h, is filtered every time, the decompression volume of merging filtrate, filtrate is concentrated into myrrh weight
4-7 times of g/ml, filter to obtain the final product.
The dipsacus root extracting solution is to be prepared by the following method：
It is appropriate to weigh dipsacus root, is ground into coarse powder, with 70% ethyl alcohol impregnate 0.15-0.8h, heating and refluxing extraction 3 times, the 1st time
Add 10~15 times of 70% ethyl alcohol of amount, extract 0.5-2h, the 2nd time plus 10-15 times measure 70% ethyl alcohol, extract 0.5-1.5h, the 3rd time plus
8-10 times is measured 70% ethyl alcohol, is extracted 0.5-1.5h, is filtered every time, the decompression volume of merging filtrate, filtrate is concentrated into dipsacus root weight
4-7 times of g/ml, filter to obtain the final product.
The Rhizoma Et Radix Notopterygii extracting solution is to be prepared by the following method：
Take Rhizoma Et Radix Notopterygii appropriate, be ground into coarse powder, with 70% ethyl alcohol impregnate 0.15-0.8h, heating and refluxing extraction 3 times, the 1st time plus
12~18 times of 70% ethyl alcohol of amount, extract 0.5-2h, and the 2nd time plus 10-15 times measure 70% ethyl alcohol, extract 0.5-1.5h, the 3rd time plus 8-
10 times of 70% ethyl alcohol of amount, extract 0.5-1.5h, filter every time, the decompression volume of merging filtrate, filtrate is concentrated into Rhizoma Et Radix Notopterygii weight
4-7 times of g/ml, is filtered to obtain the final product.
The Cortex Acanthopanacis Radicis extracting solution is to be prepared by the following method：
Take Cortex Acanthopanacis Radicis appropriate, be ground into coarse powder, with 75% ethyl alcohol impregnate 0.15-0.8h, heating and refluxing extraction 3 times, the 1st
Secondary plus 8~16 times of 75% ethyl alcohol of amount, extract 0.5-2h, and the 2nd time plus 8-12 times measure 75% ethyl alcohol, extract 0.5-1.5h, the 3rd time plus
8-10 times is measured 75% ethyl alcohol, is extracted 0.5-1.5h, is filtered every time, the decompression volume of merging filtrate, filtrate is concentrated into Cortex Acanthopanacis Radicis
4-7 times of g/ml of weight, is filtered to obtain the final product.
A kind of preparation method of the ointment for treating bone fracture and injury of extract containing natural component provided by the invention, including following step
Suddenly：
A) weigh Carbopol 941 0.2-0.8g, be added in 50-100ml distilled water, it is to be mixed uniformly after, standing allow it
Fully swelling, obtains gel 1, for use；
B) ice crystal forming agent AVC 0.1-0.9g are weighed, are added in the distilled water of 50-100ml, it is to be mixed uniformly after, it is quiet
It sets and it is allowed fully to be swollen, obtain gel 2, for use；
C) aloe 1-5g, fat of Oromaius norvaehollandeae 1-5g, turpentine oil 1-5g, oil of zedoary turmeric 1-5g, badger seed oil 1-5g, borage oil are weighed
1-5g, rose hip oil 1-5g, 82 3-5g of wheat source emulsifier MONTANOV, heat on 70-100 DEG C of water-bath, wait for
After mixing, as oil phase, for use；
D) 14-35ml distilled water is measured, 70-100 DEG C of heating water bath is placed in, it is for use as water phase；
E) it waits for that oil phase is identical with water phase temperature, water phase is added in thread shape in oil phase, it is stirring while adding until being formed
Uniform emulsion bases a；
F) it is added into emulsion bases a and does not have medicament extracting solution 2-5ml and own extracting solution 2-5ml, dipsacus root extracting solution 2-5ml, Qiang
Work extracting solution 2-5ml, Cortex Acanthopanacis Radicis extracting solution 2-5ml, gel 1, gel 2, glycerine 1-5ml, 0.2% ethylparaben, 75% second
Alcoholic solution 0.5-1ml is uniformly mixed the ointment for treating bone fracture and injury to get the extract containing natural component.
Each ingredient in the present invention is as follows：
Aloe has strong osmoticum, nutrient can be helped to penetrate into flesh containing natural colloidality substance, water conservation lignin
Skin, not only viral infection resisting, promotion wound healing are restored for effect, also have anti-inflammation and sterilization, heat absorption detumescence, softening skin, guarantor
The function of cell viability is held, that is, releases hardening, angling, improves the effect of scar.
Rose hip oil contains γ-linolenic acid, unsaturated fatty acid, palmitic acid, citric acid, vitamin A, C, carotenoids
Element.Wherein mostly important this necessary aliphatic acid has soft skin effect for skin for γ-linolenic acid, has tissue
Regenerated ability can effectively improve the scar caused by scar, dark sore, whelk.
Contain γ-linolenic acid in borage oil, activity is more than ten times high compared with compared with other linolenic acids, flax
Oleic acid is used for wound healing, moreover it is possible to expand blood vessel, improve skin elasticity, restore skin gloss.
Turpentine oil is a kind of natural essential oil, and a variety of terpene hydrocarbon mixtures based on firpene, penetration power is strong, can penetrate into deep
Tissue shows stimulation, promotes blood circulation and have concurrently the effect of disinfection, has resisting rheumatoid arthritis, the works such as antibacterial
With for courbature or arthralgia.Firpene in turpentine oil can make patient injury quickly heal, and promotion is histoclastic quickly to repair
It is multiple, and the normal barrier function of skin can be repaired.The sterilization of firpene can also prevent the infection in affected part.
Myrrh has the effect of dissipating blood stasis eliminatings, detumescence and promoting granulation analgesic therapy, is usually used in arthralgia pain due to rheumatism, traumatic injury, metal-inflicted wound, carbuncle swells
Sore, injury pain, injured in the sinews or bones, torpor and swelling, internal injury hemostasis, the treatment of the illnesss such as limb arm pain.《Haigoushen》：Zhu Das E
Damage, trusted subordinate's blood stasis, Shang Zhe Wei fall, and muscles and bones stasis caused pain, golden sword is damaged, unbearably painful, all throw drink with wine.《Compendium of Materia Medica》：Dissipate blood
Detumescence, analgesic therapy myogenic.《Kaibao Bencao》：Main blood-breaking analgesic.Treat cane sore, all malignant sores.
Blood vessels are adjusted in dipsacus root filling liver kidney, strengthening the bones and muscles, are continued injured, are walked channels and collaterals.For aching pain in waist and back, podomere Impotence numbness falls and flutters wound
Wound, damage muscle roll over bone, ulcer sore swells.Wine dipsacus root is chiefly used in arthralgia pain due to rheumatism, injury from falling down.Salt dipsacus root is chiefly used in soreness and weakness of waist and knees.《The southern regions of the Yunnan Province
Book on Chinese herbal medicine》：Channels and collaterals are determined in tonifying liver, strengthening the bones and muscles, and (muscles and bones) is ached in only passing through, tocolysis, raw new blood, broken stasis of blood blood, and cough-relieving is coughed hemoptysis.《The legendary god of farming
Book on Chinese herbal medicine warp》：Main typhoid fever, tonifying for the deficiency, metal-inflicted wound, large carbuncle, folding fall, continuous muscles and bones, and married woman's breast is difficult, long term usage benefiting energy.《Mingyi Bielu》：It is main
Metrorrhagia leaks blood, is leaked in metal-inflicted wound blood, analgesic, myogenic Rou , Wan wounds, extravesated blood, pain in the back, joint emergency.
Rhizoma Et Radix Notopterygii dissipates exterior cold, expelling wind and eliminating dampness, sharp joint, analgesic.For waist and knee crymodynia, geomantic omen edema, sore swollen toxin, sharp joint
With the analgesic effect in affected part.《Pearl sac》：Remove all arthralgias.《Product remittance essence is wanted》：Main all joints being painful all over, fleshy exterior Bafeng thief
Heresy removes new and old rheumatism, arranges slough subcutaneous ulcer sore.
Cortex Acanthopanacis Radicis wind-damp dispelling, filling liver kidney strengthen the bone, blood circulation and promoting silt.Wind-cold-dampness arthralgia is cured mainly, muscles and bones contraction is anxious, and impotence is soft, action
It is slow, physically weak, lumbocrural pain, oedema, tinea pedis, sore subcutaneous ulcer pyogenic infections, fracture, traumatic injury etc..《Compendium of Materia Medica》：Control rheumatism impotence
Numbness strengthens the bone.《Yunnan Chinese herbal medicine》：Traumatic injury is controlled, is fractured, sore.《Shaanxi Chinese herbal medicine》：Activating blood circulation and reducing swelling controls rheumatoid arthrosis
Bitterly, traumatic injury, oedema, difficult urination.
And own removing toxicity for detumescence, it is promoting blood circulation and removing blood stasis.《Modern Chinese herbal medicine voluminous dictionary》Record and own function：Promoting blood circulation to remove blood stasis, wind-dispelling stop
Bitterly, detoxify desinsection.Traumatic injury is cured mainly, is fractured, Amenorrhea, (Chinese medicine rheumatism bi Zheng scope includes the rheumatism of doctor trained in Western medicine to arthralgia pain due to rheumatism etc.
The diseases such as property arthritis, rheumatoid arthritis).《National Chinese herbal medicine compilation》Record and own relaxing tendons and activating collaterals, detumescence anti-inflammatory, cure mainly
Traumatic injury, fracture, strain etc..
Glycerine is a kind of sorbefacient of polyalcohol, and turpentine oil is also a kind of sorbefacient, can effectively facilitate turpentine
Oil, borage oil, oil of zedoary turmeric, rose hip oil, badger seed oil, aloe, fat of Oromaius norvaehollandeae, myrrh and oneself, dipsacus root, Rhizoma Et Radix Notopterygii, Cortex Acanthopanacis Radicis
The absorption of the active ingredients such as extract.Borage oil therein curative effect in terms of treat wound healing is stronger, and aloe is to wound
The removing of mouthful scar is significant in efficacy, and the two, which is used in combination, the cancellation of the healing at patient's pain of injury and scar after healing
Synergistic effect.Myrrh dissipates blood stasis eliminatings, detumescence and promoting granulation analgesic therapy；Blood vessels are adjusted in dipsacus root filling liver kidney, strengthening the bones and muscles, are continued injured, are walked channels and collaterals；Qiang
Scattered exterior cold living, expelling wind and eliminating dampness, sharp joint, analgesic；Cortex Acanthopanacis Radicis wind-damp dispelling, filling liver kidney strengthen the bone, blood circulation and promoting silt；And oneself detoxifies
Detumescence, it is promoting blood circulation and removing blood stasis.Various both effectiveness ingredients complement each other, and have good promoting blood circulation analgesic effect for traumatic injury.
Compared with existing product, have pharmacological property mild, it is safe, the features such as Small side effects, using in natural drug
Active material promotes skin health growth, restores the normal barrier function of skin itself, active ingredient is mostly natural drug, to falling
Play damage, promoting blood circulation has apparent therapeutic effect.In addition there is calm antipruritic, elimination redness, soothe the skin surface layer, alleviation skin
The effect of skin scabs has the effect of being relieved traumatic injury situation.
Specific implementation mode
With reference to specific embodiment, the invention will be further described.
Turpentine oil, borage oil, oil of zedoary turmeric, rose hip oil, badger seed oil, aloe, fat of Oromaius norvaehollandeae used in the present invention are
It is commercially available.
Embodiment 1
A kind of ointment for treating bone fracture and injury of the extract containing natural component, including following raw material：
A kind of preparation method of the ointment for treating bone fracture and injury of the extract containing natural component, includes the following steps：
1.1 and own extracting solution preparation
It weighs and own 100g, is ground into coarse powder, 70% ethyl alcohol immersion 0.5h, heating and refluxing extraction 3 times, the 1st time plus 10
Times amount 70% ethyl alcohol, extract 1h, the 2nd time plus 8 times amount 70% ethyl alcohol, extract 1h, the 3rd time plus 8 times amount 70% ethyl alcohol, extract 1h,
Every time filtration, the decompression volume of merging filtrate, filtrate be concentrated into and own weight 6 times (g/ml), filter to obtain the final product.
1.2 do not have the preparation of medicament extracting solution
Myrrh 100g is weighed, coarse powder is ground into, impregnates 0.5h with 95% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 10
Times amount 95% ethyl alcohol, extract 1h, the 2nd time plus 8 times amount 95% ethyl alcohol, extract 1h, the 3rd time plus 7 times amount 95% ethyl alcohol, extract 1h,
Filtration, the decompression volume of merging filtrate, filtrate are concentrated into 4 times (g/ml) of myrrh weight, filter every time to obtain the final product.
The preparation of 1.3 dipsacus root extracting solutions
It is appropriate to weigh dipsacus root, is ground into coarse powder, impregnates 0.5h with 70% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 10
Times amount 70% ethyl alcohol, extract 1h, the 2nd time plus 10 times amount 70% ethyl alcohol, extract 1h, the 3rd time plus 8 times amount 70% ethyl alcohol, extract 1h,
Filtration, the decompression volume of merging filtrate, filtrate are concentrated into 4 times (g/ml) of dipsacus root weight, filter every time to obtain the final product.
The preparation of 1.4 Rhizoma Et Radix Notopterygii extracting solutions
It is appropriate to weigh Rhizoma Et Radix Notopterygii, is ground into coarse powder, impregnates 0.5h with 70% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 12
Times amount 70% ethyl alcohol, extract 1h, the 2nd time plus 11 times amount 70% ethyl alcohol, extract 1h, the 3rd time plus 9 times amount 70% ethyl alcohol, extract 1h,
Filtration, the decompression volume of merging filtrate, filtrate are concentrated into 4 times (g/ml) of Rhizoma Et Radix Notopterygii weight, filter every time to obtain the final product.
The preparation of 1.5 Cortex Acanthopanacis Radicis extracting solutions
It is appropriate to weigh Cortex Acanthopanacis Radicis, is ground into coarse powder, with 75% ethyl alcohol impregnate 0.5h, heating and refluxing extraction 3 times, the 1st time
Add 10 times of 75% ethyl alcohol of amount, extract 1h, the 2nd time plus 8 times 75% ethyl alcohol of amount extracts 1h, and the 3rd time plus 12 times 75% ethyl alcohol of amount carries
It takes 1h, filters every time, the decompression volume of merging filtrate, filtrate is concentrated into 5 times (g/ml) of wilsonii weight, filters to obtain the final product.
The preparation of 1.6 ointment for injuries
A) weigh Carbopol 941 0.5g, be added in the distilled water of 100ml, it is to be mixed uniformly after, standing allow its fully
Swelling, obtains gel 1, for use；
B) ice crystal forming agent AVC 0.5g are weighed, are added in the distilled water of 100ml, it is to be mixed uniformly after, standing allow it
Fully swelling, obtains gel 2, for use；
C) aloe 1g, fat of Oromaius norvaehollandeae 1g, turpentine oil 1g, oil of zedoary turmeric 1g are taken, badger seed oil 1g, borage oil 1g, rose hip oil
82 3g of 1g, wheat source emulsifier MONTANOV, is heated on 80 DEG C of water-bath, it is to be mixed uniformly after, as oil phase, wait for
With；
D) 8ml distilled water is measured, 80 DEG C of heating water baths are placed in, it is for use as water phase；
E) it waits for that oil phase is identical with water phase temperature, water phase is added in thread shape in oil phase, it is stirring while adding until being formed
Uniform emulsion bases a；
F) it is added into emulsion bases a and does not have medicament extracting solution 4ml and own extracting solution 4ml, dipsacus root extracting solution 4ml, Rhizoma Et Radix Notopterygii extraction
Liquid 4ml, Cortex Acanthopanacis Radicis extracting solution 4ml, gel 1, gel 2, glycerine 1.5-3ml, 0.2% ethylparaben, 75% ethanol solution
1ml is uniformly mixed to get ointment for injuries.
Embodiment 2
A kind of ointment for treating bone fracture and injury of the extract containing natural component, including following raw material：
A kind of preparation method of the ointment for treating bone fracture and injury of the extract containing natural component, includes the following steps：
2.1 and own extracting solution preparation
It weighs and own 80g, is ground into coarse powder, 70% ethyl alcohol immersion 0.5h, heating and refluxing extraction 3 times, the 1st time plus 12 times
70% ethyl alcohol to be measured, 1h is extracted, the 2nd time plus 10 times 70% ethyl alcohol of amount extracts 1h, and the 3rd time plus 8 times 70% ethyl alcohol of amount extracts 1.5h,
Every time filtration, the decompression volume of merging filtrate, filtrate be concentrated into and own weight 5 times (g/ml), filter to obtain the final product.
2.2 do not have the preparation of medicament extracting solution
Myrrh 80g is weighed, coarse powder is ground into, impregnates 0.5h, heating and refluxing extraction 3 times, the 1st time plus 12 times with 95% ethyl alcohol
95% ethyl alcohol is measured, 1h is extracted, the 2nd time plus 10 times 95% ethyl alcohol of amount extracts 1h, and the 3rd time plus 9 times 95% ethyl alcohol of amount extracts 1h, often
The decompression volume of secondary filtration, merging filtrate, filtrate is concentrated into 5 times (g/ml) of myrrh weight, filters to obtain the final product.
The preparation of 2.3 dipsacus root extracting solutions
Dipsacus root 80g is weighed, coarse powder is ground into, impregnates 0.5h, heating and refluxing extraction 3 times, the 1st time plus 12 times with 70% ethyl alcohol
70% ethyl alcohol is measured, 1h is extracted, the 2nd time plus 10 times 70% ethyl alcohol of amount extracts 1h, and the 3rd time plus 8 times 70% ethyl alcohol of amount extracts 1h, often
The decompression volume of secondary filtration, merging filtrate, filtrate is concentrated into 5 times (g/ml) of dipsacus root weight, filters to obtain the final product.
The preparation of 2.4 Rhizoma Et Radix Notopterygii extracting solutions
It is appropriate to weigh Rhizoma Et Radix Notopterygii, is ground into coarse powder, impregnates 0.5h with 70% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 12
Times amount 70% ethyl alcohol, extract 1h, the 2nd time plus 10 times amount 70% ethyl alcohol, extract 1h, the 3rd time plus 9 times amount 70% ethyl alcohol, extract 1h,
Filtration, the decompression volume of merging filtrate, filtrate are concentrated into 4 times (g/ml) of Rhizoma Et Radix Notopterygii weight, filter every time to obtain the final product.
The preparation of 2.5 Cortex Acanthopanacis Radicis extracting solutions
It is appropriate to weigh Cortex Acanthopanacis Radicis, is ground into coarse powder, with 75% ethyl alcohol impregnate 0.5h, heating and refluxing extraction 3 times, the 1st time
Add 12 times of 75% ethyl alcohol of amount, extract 1h, the 2nd time plus 10 times 75% ethyl alcohol of amount extracts 1h, and the 3rd time plus 10 times 75% ethyl alcohol of amount carries
It takes 1h, filters every time, the decompression volume of merging filtrate, filtrate is concentrated into 7 times (g/ml) of wilsonii weight, filters to obtain the final product.
The preparation of 2.6 ointment for injuries
A) weigh Carbopol 941 0.8g, be added in the distilled water of 100ml, it is to be mixed uniformly after, standing allow its fully
Swelling, obtains gel 1, for use；
B) ice crystal forming agent AVC 0.9g are weighed, are added in the distilled water of 100ml, it is to be mixed uniformly after, standing allow it
Fully swelling, obtains gel 2, for use；
C) aloe 5g, fat of Oromaius norvaehollandeae 5g, turpentine oil 5g, oil of zedoary turmeric 5g are taken, badger seed oil 5g, borage oil 5g, rose hip oil
82 5g of 5g, wheat source emulsifier MONTANOV, is heated on 80 DEG C of water-bath, it is to be mixed uniformly after, as oil phase, wait for
With；
D) 35ml distilled water is measured, 80 DEG C of heating water baths are placed in, it is for use as water phase；
E) it waits for that oil phase is identical with water phase temperature, water phase is added in thread shape in oil phase, it is stirring while adding until being formed
Uniform emulsion bases a；
F) it is added into emulsion bases a and does not have medicament extracting solution 5ml and own extracting solution 5ml, dipsacus root extracting solution 5ml, Rhizoma Et Radix Notopterygii extraction
Liquid 5ml, Cortex Acanthopanacis Radicis extracting solution 5ml, gel 1, gel 2, glycerine 2ml, 0.2% ethylparaben, 75% ethanol solution 1ml, are stirred
Mix the ointment for treating bone fracture and injury being uniformly mixed to get the extract containing natural component.
Embodiment 3
A kind of ointment for treating bone fracture and injury of the extract containing natural component, including following raw material：
A kind of preparation method of the ointment for treating bone fracture and injury of the extract containing natural component, includes the following steps:
3.1 and own extracting solution prepare
It weighs and own 150g, is ground into coarse powder, 70% ethyl alcohol immersion 0.5h, heating and refluxing extraction 3 times, the 1st time plus 11
Times amount 70% ethyl alcohol, extract 1h, the 2nd time plus 8 times amount 70% ethyl alcohol, extract 1h, the 3rd time plus 9 times amount 70% ethyl alcohol, extract 1h,
Every time filtration, the decompression volume of merging filtrate, filtrate be concentrated into and own weight 4 times (g/ml), filter to obtain the final product.
3.2 do not have the preparation of medicament extracting solution
Myrrh 150g is weighed, coarse powder is ground into, impregnates 0.5h with 95% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 11
Times amount 95% ethyl alcohol, extract 1h, the 2nd time plus 8 times amount 95% ethyl alcohol, extract 1h, the 3rd time plus 8 times amount 95% ethyl alcohol, extract 1h,
Filtration, the decompression volume of merging filtrate, filtrate are concentrated into 5 times (g/ml) of myrrh weight, filter every time to obtain the final product.
The preparation of 3.3 dipsacus root extracting solutions
Dipsacus root 70g is weighed, coarse powder is ground into, impregnates 0.5h, heating and refluxing extraction 3 times, the 1st time plus 11 times with 70% ethyl alcohol
70% ethyl alcohol is measured, 1h is extracted, the 2nd time plus 11 times 70% ethyl alcohol of amount extracts 1h, and the 3rd time plus 9 times 70% ethyl alcohol of amount extracts 1h, often
The decompression volume of secondary filtration, merging filtrate, filtrate is concentrated into 6 times (g/ml) of dipsacus root weight, filters to obtain the final product.
The preparation of 3.4 Rhizoma Et Radix Notopterygii extracting solutions
Rhizoma Et Radix Notopterygii 80g is weighed, coarse powder is ground into, impregnates 0.5h, heating and refluxing extraction 3 times, the 1st time plus 12 times with 70% ethyl alcohol
70% ethyl alcohol to be measured, 1h is extracted, the 2nd time plus 10 times 70% ethyl alcohol of amount extracts 1h, and the 3rd time plus 10 times 70% ethyl alcohol of amount extracts 1h,
Filtration, the decompression volume of merging filtrate, filtrate are concentrated into 4 times (g/ml) of Rhizoma Et Radix Notopterygii weight, filter every time to obtain the final product.
It is prepared by 3.5 Cortex Acanthopanacis Radicis extracting solutions
Weigh Cortex Acanthopanacis Radicis 80g, be ground into coarse powder, with 75% ethyl alcohol impregnate 0.5h, heating and refluxing extraction 3 times, the 1st time plus
11 times of 75% ethyl alcohol of amount, extract 1h, and the 2nd time plus 8 times 75% ethyl alcohol of amount extracts 1h, the 3rd time plus 9 times 75% ethyl alcohol of amount, extraction
1h, filters every time, and the decompression volume of merging filtrate, filtrate is concentrated into 7 times (g/ml) of wilsonii weight, filters to obtain the final product.
A kind of preparation method of ointment for injuries described in 3.6, includes the following steps：
A) weigh Carbopol 941 0.5g, be added in the distilled water of 100ml, it is to be mixed uniformly after, standing allow its fully
Swelling, obtains gel 1, for use；
B) ice crystal forming agent AVC 0.5g are weighed, are added in the distilled water of 100ml, it is to be mixed uniformly after, standing allow it
Fully swelling, obtains gel 2, for use；
C) aloe 2.5g, fat of Oromaius norvaehollandeae 2.5g, turpentine oil 2.5g, oil of zedoary turmeric 2.5g, badger seed oil 2.5g, borage oil are taken
2.5g, rose hip oil 2.5g, 82 3g of wheat source emulsifier MONTANOV, are heated on 80 DEG C of water-bath, to be mixed equal
After even, as oil phase, for use；
D) 8ml distilled water is measured, 80 DEG C of heating water baths are placed in, it is for use as water phase；
E) it waits for that oil phase is identical with water phase temperature, water phase is added in thread shape in oil phase, it is stirring while adding until being formed
Uniform emulsion bases a；
F) it is added into emulsion bases a and does not have medicament extracting solution 2ml and own extracting solution 2ml, dipsacus root extracting solution 2ml, Rhizoma Et Radix Notopterygii extraction
Liquid 2ml, Cortex Acanthopanacis Radicis extracting solution 2ml, gel 1, gel 2, glycerine 2ml, 0.2% ethylparaben, 75% ethanol solution 1ml, are stirred
It mixes and is uniformly mixed to get ointment for injuries.
Test example 1
The physical and chemical index of embodiment 1,2,3 is as follows：
1.1 character
This product is that viscosity is suitable, fine and smooth uniform, the good milky ointment of stretchability.
1.2 pH value inspections
A small amount of emulsifiable paste is dipped with the pH test paper of wetting, as a result pH is 6-7.
1.3 caloric test
Emulsifiable paste is packaged in transparent emulsifiable paste bottle, in 4 DEG C of refrigerator cold-storage observations in one week or so without lamination.In 55 DEG C
Insulating box in for 24 hours, it is no layering, it is spoiled phenomena such as.
1.4 centrifugal test
Emulsifiable paste is packaged in 3000r/min in tool plug test tube and centrifuges 20min, no lamination.
1.5 irritation tests, anaphylaxis experiment
Small white mouse back cuts off hair, smears the emulsifiable paste that is prepared by embodiment 1,2,3 respectively in cutting plucked position, and do not apply
Position is compared, as a result without irritation and allergic reaction.
Emulsifiable paste prepared by Example 1,2,3 is applied in right amount in volunteer (15-65 Sui, 25 people) gesture and facial expression, after spending 30 minutes
Phenomenon of blistering, does not occur rubescent, dermexanthesis, in observation.
1.6 are placed at room temperature for experiment
1,2,3 made emulsifiable paste of embodiment is placed in bottle, is stored at room temperature investigation 6 months, no lamination is felt after
Unchanged, smell is unchanged.
1.7 medicinal effects
Volunteer's (15-65 Sui, 25 people) is chosen, obtained emulsifiable paste is used for volunteer's affected part, volunteers generally feel
Feel comfortable, is all used continuously without special reaction after skin use, affected part is obviously improved.
2. the emulsifiable paste resultant effect is investigated
Following with trial effect come the effect of evaluating emulsifiable paste that embodiment 1,2,3 produces.It is scored using opinion poll
Method chooses the patient of 60 15-65 Sui age brackets as object is tried out, is arbitrarily divided into three groups, uses embodiment 1,2,3 to make respectively
Standby emulsifiable paste is applied to affected part.Daily sooner or later using twice, usage time is fortnight.Every using effect total score is 5 points：5
It is divided into best result, indicates fine, it is very satisfied；4 points are preferable；3 points are that can receive；3 points or less are bad, cannot be received.
It is every average below.It the results are shown in Table 1：
1 resultant effect of table is investigated
Emulsifiable paste obtained by the present invention is fine and smooth, uniform, has promoting blood circulation, treats the effect of traumatic injury, and side effect
Very little.
Claims (7)
1. a kind of ointment for treating bone fracture and injury of extract containing natural component, which is characterized in that the extract containing natural component falls
Damage ointment is played to be made of following raw material：
Fat of Oromaius norvaehollandeae 1-5g
Turpentine oil 1-5g
Oil of zedoary turmeric 1-5g
Badger seed oil 1-5g
Aloe 1-5g
Borage oil 1-5g
Rose hip oil 1-5g
82 3-5g of wheat source emulsifier MONTANOV
Do not have medicament extracting solution 2-5ml
And own extracting solution 2-5ml
Dipsacus root extracting solution 2-5ml
Rhizoma Et Radix Notopterygii extracting solution 2-5ml
Cortex Acanthopanacis Radicis extracting solution 2-5ml
Carbopol 941 0.2-0.8g
Ice crystal forming agent AVC 0.1-0.9g
Glycerine 1-5ml
Distilled water 114-235ml
0.2% ethylparaben, 75% ethyl alcohol alcoholic solution 0.5-1ml.
2. the ointment for treating bone fracture and injury of the extract according to claim 1 containing natural component, which is characterized in that it is described and oneself
Extracting solution is to be prepared by the following method：
It weighs and oneself is appropriate, be ground into coarse powder, 70% ethyl alcohol immersions 0.15-0.8h, heating and refluxing extraction 3 times, add 8 for the 1st time ~
18 times of 70% ethyl alcohol of amount, extract 0.5-2h, and the 2nd time plus 8-15 times measure 70% ethyl alcohol, extract 0.5-1.5h, measure for the 3rd time plus 8-10 times
70% ethyl alcohol extracts 0.5-1.5h, filters every time, the decompression volume of merging filtrate, filtrate is concentrated into and 4-7 times of g/ of own weight
Ml is filtered to obtain the final product.
3. the ointment for treating bone fracture and injury of the extract according to claim 1 or 2 containing natural component, which is characterized in that described
It is to be prepared by the following method not have medicament extracting solution：
It is appropriate to weigh myrrh, is ground into coarse powder, impregnates 0.15-0.8h with 95% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 10 ~
20 times of 95% ethyl alcohol of amount, extract 0.5-2h, and the 2nd time plus 8-15 times measure 95% ethyl alcohol, extract 0.5-1.5h, measure for the 3rd time plus 8-10 times
95% ethyl alcohol extracts 0.5-1.5h, filters every time, and the decompression volume of merging filtrate, filtrate is concentrated into 4-7 times of g/ of myrrh weight
Ml is filtered to obtain the final product.
4. the ointment for treating bone fracture and injury of the extract according to claim 1 or 2 containing natural component, which is characterized in that the river
Disconnected extracting solution is to be prepared by the following method：
It is appropriate to weigh dipsacus root, is ground into coarse powder, impregnates 0.15-0.8h with 70% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 10 ~
15 times of 70% ethyl alcohol of amount, extract 0.5-2h, and the 2nd time plus 10-15 times measure 70% ethyl alcohol, extract 0.5-1.5h, measure for the 3rd time plus 8-10 times
70% ethyl alcohol extracts 0.5-1.5h, filters every time, and the decompression volume of merging filtrate, filtrate is concentrated into 4-7 times of g/ of dipsacus root weight
Ml is filtered to obtain the final product.
5. the ointment for treating bone fracture and injury of the extract according to claim 1 or 2 containing natural component, which is characterized in that described
Rhizoma Et Radix Notopterygii extracting solution is to be prepared by the following method：
It takes Rhizoma Et Radix Notopterygii appropriate, is ground into coarse powder, impregnate 0.15-0.8h with 70% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 12 ~ 18
Times 70% ethyl alcohol of amount, extracts 0.5-2h, and the 2nd time plus 10-15 times measure 70% ethyl alcohol, extract 0.5-1.5h, measures for the 3rd time plus 8-10 times
70% ethyl alcohol extracts 0.5-1.5h, filters every time, and the decompression volume of merging filtrate, filtrate is concentrated into 4-7 times of g/ of Rhizoma Et Radix Notopterygii weight
Ml is filtered to obtain the final product.
6. the ointment for treating bone fracture and injury of the extract according to claim 1 or 2 containing natural component, which is characterized in that described
Cortex Acanthopanacis Radicis extracting solution is to be prepared by the following method：
It takes Cortex Acanthopanacis Radicis appropriate, is ground into coarse powder, impregnate 0.15-0.8h with 75% ethyl alcohol, heating and refluxing extraction 3 times, the 1st time plus 8
~ 16 times of 75% ethyl alcohol of amount, extract 0.5-2h, and the 2nd time plus 8-12 times measure 75% ethyl alcohol, extract 0.5-1.5h, measure for the 3rd time plus 8-10 times
75% ethyl alcohol extracts 0.5-1.5h, filters every time, and merging filtrate, the decompression volume of filtrate is concentrated into the 4-7 of Cortex Acanthopanacis Radicis weight
Times g/ml, is filtered to obtain the final product.
7. a kind of preparation method of the ointment for treating bone fracture and injury of claim 1-6 any one of them extract containing natural component,
It is characterized in that, the preparation method comprises the following steps：
a）Weigh Carbopol 941 0.2-0.8g, be added in 50-100ml distilled water, it is to be mixed uniformly after, standing allow its fully
Swelling, obtains gel 1, for use；
b）Weigh ice crystal forming agent 0.1-0.9g, be added in the distilled water of 50-100ml, it is to be mixed uniformly after, standing allow it to fill
Divide swelling, obtains gel 2, for use；
c）Weigh aloe 1-5g, fat of Oromaius norvaehollandeae 1-5g, turpentine oil 1-5g, oil of zedoary turmeric 1-5g, badger seed oil 1-5g, borage oil 1-
5g, rose hip oil 1-5g, 82 3-5g of wheat source emulsifier MONTANOV, heat on 70-100 DEG C of water-bath, wait mixing
After closing uniformly, as oil phase, for use；
d）14-35ml distilled water is measured, 70-100 DEG C of heating water bath is placed in, it is for use as water phase；
e）It waits for that oil phase is identical with water phase temperature, water phase is added in thread shape in oil phase, it is stirring while adding until being formed uniform
Emulsion bases a；
f）Being added into emulsion bases a does not have medicament extracting solution 2-5ml and own extracting solution 2-5ml, dipsacus root extracting solution 2-5ml, Rhizoma Et Radix Notopterygii to carry
Take liquid 2-5ml, Cortex Acanthopanacis Radicis extracting solution 2-5ml, gel 1, gel 2, glycerine 1-5ml, 0.2% ethylparaben, 75% ethanol solution
0.5-1ml is uniformly mixed the ointment for treating bone fracture and injury to get the extract containing natural component.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510658027.4A CN105126037B (en) | 2015-10-10 | 2015-10-10 | A kind of ointment for treating bone fracture and injury of the extract containing natural component and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510658027.4A CN105126037B (en) | 2015-10-10 | 2015-10-10 | A kind of ointment for treating bone fracture and injury of the extract containing natural component and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105126037A CN105126037A (en) | 2015-12-09 |
| CN105126037B true CN105126037B (en) | 2018-08-14 |
Family
ID=54711848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510658027.4A Active CN105126037B (en) | 2015-10-10 | 2015-10-10 | A kind of ointment for treating bone fracture and injury of the extract containing natural component and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105126037B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107308139A (en) * | 2017-08-01 | 2017-11-03 | 皖南医学院 | It is a kind of to treat cataplasm of arthralgia and preparation method thereof |
| CN107854595A (en) * | 2017-12-16 | 2018-03-30 | 李竑靓 | A kind of preparation method of external use medicament for traumatic injury wine |
| CN112386669A (en) * | 2020-12-17 | 2021-02-23 | 江西昊极健康咨询服务有限公司 | Herbal collateral-activating paste for promoting blood circulation, removing blood stasis, relaxing muscles and tendons and activating collaterals and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101428080A (en) * | 2008-12-10 | 2009-05-13 | 黄杰 | Health care essential oil of magnolia flower |
| CN104147533A (en) * | 2014-08-27 | 2014-11-19 | 皖南医学院 | Blood-activating, stasis-resolving and pain-relieving cream and preparation method thereof |
-
2015
- 2015-10-10 CN CN201510658027.4A patent/CN105126037B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101428080A (en) * | 2008-12-10 | 2009-05-13 | 黄杰 | Health care essential oil of magnolia flower |
| CN104147533A (en) * | 2014-08-27 | 2014-11-19 | 皖南医学院 | Blood-activating, stasis-resolving and pain-relieving cream and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105126037A (en) | 2015-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104147533B (en) | A kind of promoting blood circulation, removing blood stasis and relieving pain emulsifiable paste and preparation method thereof | |
| CN103961636B (en) | Orthopedic disease treatment external application traditional Chinese medicine composition, preparation method and application thereof | |
| CN107468850A (en) | Chinese medicine composition, preparation method and applications and Chinese medicine preparation and preparation method thereof | |
| CN105126037B (en) | A kind of ointment for treating bone fracture and injury of the extract containing natural component and preparation method thereof | |
| CN101143166B (en) | Medicine for swelling and relieving pain and its preparation method and application | |
| CN105055849B (en) | Enriching yin Chinese medical extract for nourishing kidney and its preparation method and application | |
| CN101979011A (en) | Traditional Chinese medicinal transdermal gel ointment for treating cervical spondylosis and preparation method thereof | |
| CN106963923A (en) | A kind of Chinese medicine composition and preparation method and application with analgesic activity | |
| CN107137471A (en) | A kind of Traditional Chinese medicine used as analgesic composition and its preparation method and application | |
| CN104623457B (en) | Vagina-shrinking expellent nti-freckle gelling agent and preparation method thereof | |
| CN102784355B (en) | First-aid drug and preparation method thereof | |
| CN110478434A (en) | A kind of Chinese medicine composition, pharmaceutical preparation and its application | |
| CN105816831B (en) | A kind of external application application therapy tremble with fear stasis of blood ostalgia Chinese medicine composition and preparation method and application | |
| CN103989968A (en) | Oral traditional Chinese medicinal composition for treating cervical spinal stenosis | |
| CN1444951A (en) | Exterior Chinese medicine Oil-in-Water (O/W) type prescription for reduce swelling and ease pain and its preparing method | |
| CN106955314A (en) | Heat-clearing river Huang of invigorating blood circulation dissipates | |
| CN1135108C (en) | Medicine for treating traumatic injury and relieving pain | |
| CN104586971B (en) | A kind of preparation method of promoting blood circulation and removing blood stasis, swelling and pain relieving the external-use analgesic liquid of energy | |
| CN106038940A (en) | External medicinal wine for treatment of fall injuries | |
| CN101607069B (en) | Chinese traditional medicine for treating phlebitis, old lower extremity venous ulcer and venous purpura disease | |
| CN100346810C (en) | Chinese medicinal preparation for treating traumatic injury and its preparation process | |
| CN101559185A (en) | External medicament for curing varicose vein of lower limbs | |
| CN1060394C (en) | Process for preparing prescription and medicinal extract of plaster for activating meridians | |
| CN105233187A (en) | External use finish treating breast diseases and preparation method thereof | |
| CN103006907B (en) | Traditional Chinese medicine composition for treating bone trauma and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20220706 Address after: 400064 11-11, building 1, No. 3 Tongjing Road, Nan'an District, Chongqing Patentee after: Chongqing Bozhuo Pharmaceutical Technology Co.,Ltd. Address before: 241002 No. 22 Wenchang West Road, Yijiang Higher Education Park, Wuhu, Anhui Patentee before: WANNAN MEDICAL College |