CN105123672B - Isolated organ High Accuracy Constant Temperature perfusion instrument - Google Patents
Isolated organ High Accuracy Constant Temperature perfusion instrument Download PDFInfo
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Abstract
The invention discloses a kind of isolated organ High Accuracy Constant Temperature perfusion instrument, comprise: organ infusion module, monitoring module and GPS locating module, wherein, described organ infusion module comprises control unit, the new liquid storage box be sequentially communicated with, artificial lung filtering container, the first peristaltic pump, organ storage box, pH meter container, the second peristaltic pump and used liquid storage box, and the temperature sensor acquisition module, ultrasonic measurement module, display translation module and the stepper motor that are electrically connected with described control unit; Described stepper motor and the first peristaltic pump and the second peristaltic pump are in transmission connection, described temperature sensor acquisition module is arranged in organ storage box, the temperature information measured is used for velocity of sound temperature-compensating, and described ultrasonic measurement module is for measuring the solution flow rate in catheter.The present invention can monitor other physiological parameter of organ, precise control of temperature and rate of flooding; Introduce GPS positioning function, contribute to the accurate transport of isolated organ, select optimal path, save the shipping time.
Description
Technical field
The invention belongs to medical instruments field, especially a kind of isolated organ High Accuracy Constant Temperature perfusion instrument.
Background technology
Along with the progress of surgical technic and the appearance of neotype immunosuppressant, organ transplant obtains as unique effective method for the treatment of organ disease in latter stage at end and greatly develops, on the whole, maintain the vigor of graft between organ storage life, be the successful precondition of organ transplant and basic guarantee, organ saves as organ transplant and has made great contribution.Although some new organ Techniques of preservings as mechanical Continuous Perfusion preserve, normal temperature preserves and started to be applied to clinical, simple Cord blood is still the first-selection at current each large organ transplant center.
Although the thoroughly whole terminal illness of healing that appears as of organ transfer operation provides possibility, but organ shortage becomes the principal element limiting this technology further genralrlization gradually, and it exacerbates this shortage in the death of transporting live body in preservation process, although the appearance of organ donation greatly alleviates the imbalance between supply and demand of transplant organ after heart death, but the high mortality in isolated organ preservation process and energy ezpenditure become one of restrictive condition, and along with the increase to donor demand, a large amount of old donor and marginal donor are used to clinical, this has higher requirement to organ preserving type.
Isolated organ Perfusion preservation instrument can consider the multiple important physiological parameter of organ, the relative constancy such as holding temperature, pH value, haemoconcentration and nergy Index, and the acquisition testing of physiological parameter information, analyzing and processing and process control can be completed in real time, it has immeasurable meaning to current medical domain.On the one hand, lasting infusion contributes to improving receptor's survival rates, increase graft oxygen supply during preservation, simultaneously strengthen energy matter supplement can improve graft fill with again after energy metabolism, reduce the accumulation of MDA, reduce oxidativestress damage, contribute to improving postoperative organ dysfunction.On the other hand, traditional Cord blood (frozen water mixed liquor) has certain destructiveness to isolated organ, and the static nutrient consumption preserved also easily makes organ inactivation, therefore how to realize high-accuracy and constant temperature control be one of pressing issues of facing of current isolated organ Perfusion preservation instrument.
Summary of the invention
Goal of the invention a: object is to provide a kind of isolated organ High Accuracy Constant Temperature perfusion instrument, to solve the problems referred to above that prior art exists, improves temperature control precision, to extend the active lifetime of isolated organ.
Technical scheme: a kind of isolated organ High Accuracy Constant Temperature perfusion instrument, comprising: organ infusion module, monitoring module and GPS locating module, wherein,
Described organ infusion module comprises control unit, the new liquid storage box be sequentially communicated with, artificial lung filtering container, the first peristaltic pump, organ storage box, pH meter container, the second peristaltic pump and used liquid storage box, and the temperature sensor acquisition module, ultrasonic measurement module, display translation module and the stepper motor that are electrically connected with described control unit; Described stepper motor and the first peristaltic pump and the second peristaltic pump are in transmission connection, and described temperature sensor acquisition module is arranged in organ storage box, and described ultrasonic measurement module is for measuring the solution flow rate in catheter;
Described monitoring module comprises the hydraulic pressure sensor, pH meter, compressor and the driven compressor module that are electrically connected with described control unit, and the signal of described hydraulic pressure sensor and pH meter is by sending into described control unit after A/D converter conversion; Described GPS locating module comprises gps antenna and FPGA module, and described FPGA module is electrically connected with described control unit.
In a further embodiment, the process of organ perfusion's module control rate of flooding is as follows:
Step 1A, utilize the temperature value of temperature sensor acquisition module to compensate the velocity of sound, velocity of sound compensation formula is as follows, and wherein c is the spread speed of ultrasonic in solution medium, and T is solution temperature:
c＝1449.2+4.632T-0.054T
2
Step 1B, to compensate in conjunction with the velocity of sound, utilize ultrasonic method of measuring to survey solution flow rate and flow, and shown by monitor, wherein ultrasonic method of measuring is surveyed flow rate of liquid formula and is:
Wherein, υ is for recording solution flow rate, and L is the line distance of ultrasonic transmitter-receiver, and θ is the sharp angle of transmitter-receiver line and catheter, and c is the spread speed of ultrasonic in solution medium, and Δ t is the difference of adverse current time and following current time;
Step 1C, control unit, according to flow-control stepper motor rotating speed, drive first, second pair of peristaltic pump work, and compare with timer by arranging register modulation value, produce the pulse width modulating signal consistent with setting value, rotating speed formula is as follows:
ω＝θ
N×f
Wherein, θ
nfor stepping motor single pulse steering angle, f is step-by-step impulse frequency, and the stepping motor synchronous work of first, second pair of peristaltic pump, realizes solution injection process jointly.
In a further embodiment, the process of monitoring module Monitoring and Controlling perfusion instrument is as follows:
Step 2A, utilizes A/D converter that the analog signal of hydraulic pressure sensor and pH meter collection is converted to data signal to schedule, preserves; Reading temperature data, preserves;
Step 2B, by touch-screen receiving control information;
Step 2C, controls compressor power output by PWM controller, controls the change of frequency of direct current compressor, thus fine adjustment refrigerating capacity or heating capacity.
In a further embodiment, the process of described GPS location is as follows:
Step 3A, obtains view of time by external interrupt and measures and navigation message, and both spliced;
Step 3B, measures pseudo-range information by time observation, is calculated the position in satellite launch moment, comprise the information such as observation satellite three-dimensional position, the elevation angle and azimuth by navigation message;
Step 3C, the ephemeris according to observation satellite is revised pseudorange, and carries out ionosphere and tropospheric correction;
Step 3D, according to positioning principle, calculates the three-dimensional position of user, corrects local zone time, and converts positional information to required coordinate format, shown by monitor.
In a further embodiment, described step 2C is further:
During normal work, temperature ring adjuster adopts large temperature difference refrigeration at full speed, the Discrete control method that little temperature difference PID regulates;
When the temperature difference is greater than critical value, double-compressor full speed operation, makes system temperature the fastest close to setting value;
When the temperature difference is less than critical value, single compressor adopts PID to regulate, and upgrades PWM dutycycle, to regulate the rotating speed of compressor.
In a further embodiment, described pH meter container comprises pH meter measuring vessel and pH meter clean container, described pH measuring vessel is for measuring the pH value of solution, and described pH clean container is used for fixed time cleaning glass electrode, and pH meter is switched between two containers by mechanical arm.
Beneficial effect: the present invention not only can improve the energy ezpenditure of traditional mixture of ice and water static state preservation and the defect of organ damage, and can monitor other physiological parameter of organ; Introduce GPS positioning function, contribute to the accurate transport of isolated organ, select optimal path, save the shipping time; The present invention can also realize more high-precision temperature and control, information real-time update, and the preservation for isolated organ is transported and provided advantage, alleviates imbalance between supply and demand to a certain extent, has potential economic society and is worth.
Accompanying drawing explanation
Fig. 1 is Constant Temperature Control Circuit with High Precision module of the present invention and be connected block diagram.
Fig. 2 is the high precision controller constant temp structural representation that isolated organ of the present invention is preserved.
Fig. 3 is ultrasonic liquid-flow measurement of the present invention and peristaltic pump circuit theory diagrams thereof.
Fig. 4 is color touch of the present invention screen control circuit figure.
Fig. 5 is GPS locating module signal wiring figure of the present invention.
Fig. 6 is that compressor control of the present invention interrupts flow chart.
Fig. 7 is monitor interface schematic diagram of the present invention.
Embodiment
A kind of isolated organ High Accuracy Constant Temperature perfusion of the invention process instrument, isolated organ can be realized and continue nutrient solution perfusion, physiological parameter monitoring and perfusion instrument GPS positioning function, when making it preserve transport, the energy matter oxygen needed for obtaining, get rid of refuse, and every physiological parameter such as holding temperature, pH value is stablized, extend organ and preserve the life-span, wherein DSP2812 is master chip (i.e. control unit, lower same), coordinate each module and work in order.
See Fig. 1, isolated organ High Accuracy Constant Temperature perfusion instrument, its circuit is primarily of organ infusion module, status monitoring regulation and control module, GPS locating module composition.Described organ infusion module mainly realizes: that filters through artificial lung is promoted to enter the tank placing isolated organ by peristaltic pump containing oxygen solution, the waste liquid simultaneously overflowed refluxes through another peristaltic pump and stores, and its circuit forms primarily of DSP2812 control module, temperature sensor acquisition module, ultrasonic measurement module, display translation module, stepper motor and peristaltic pump driver module.
As can be seen from Fig. 1, what be electrically connected with control unit has LCD monitor, touch panel, stepper motor, FLASH memory, compressor, pH glass electrode cleaning machine mechanical arm, RTC clock, FPGA and temperature sensor, resistance gauge and pH meter, and stepper motor is electrically connected with peristaltic pump.Compressor is by AC/DC Power supply.The analog signal that resistance gauge and pH meter gather, after the process such as filter and amplification, converts data signal to by ADC, and delivers to control unit further.
The output of temperature sensor acquisition module is connected with the input of DSP2812 control module, reads temperature information, for velocity of sound temperature-compensating; The output of ultrasonic measurement module is connected with the input of DSP2812 control module, for measuring catheter solution flow rate; The output of display translation module is connected with the input of DSP2812 control module, for monitoring flow rate information; Stepper motor is connected with the input of DSP2812 control module with the output of peristaltic pump driver module, for controlling solution flow rate.
Described status monitoring regulation and control module mainly realizes: the collection display of the information such as the accommodating the temperature inside the box of organ, pH value, flow resistance, and utilize compressor cooling to heat to carry out temperature control, its circuit is primarily of DSP2812 control module, sensor acquisition module, AD conversion module, display translation module, driven compressor module composition.
Sensor acquisition module is made up of temperature sensor JHL-506, hydraulic pressure sensor, EST-701Y glass pH combination electrode sensor, wherein the output of temperature sensor is connected with the input of DSP2812 control module, hydraulic pressure sensor is connected with AD conversion module with the output of pH combination electrode sensor, the former is digital sensor, is analog sensor both rear; The output of AD conversion module is connected with the input of DSP2812 control module, for analog signal is converted to data signal; The output of DSP2812 control module is connected with the input of driven compressor module, heats driving for compressor cooling.
Described GPS locating module, be mainly used in the GPS positioning function realizing transporting isolated organ instrument, its three-dimensional location coordinates is shown by monitor, its circuit is primarily of gps antenna, radio-frequency front-end GP2015, synchronous logic FPGA module (EP1C3T144C8N), DSP2812 control module, display translation module forms.
The described output of radio-frequency front-end GP2015 is connected with the input of FPGA module, for the correlation filtering of settling signal and down coversion and A/D sampling; Described FPGA module and the mutual input and output of DSP2812 control module, carry out information communication; Wherein, the interrelated logic of FPGA settling signal controls; DSP2812 control module primary responsibility signal capture, software is correlated with, and tracking loop data demodulates observation calculates.The output of described DSP2812 control module is connected with the input of display translation module, for the display of locating information.
See Fig. 2, isolated organ High Accuracy Constant Temperature perfusion instrument, its apparatus structure comprises the parts such as organ storage box, pH meter container, artificial lung filtering container, solution storage box, compressor, radiator, peristaltic pump, ultrasonic liquid-flow measuring device, monitor, control panel and control circuit, jointly to complete the perfusion of isolated organ, monitoring and positioning function.Described organ infusion module, its structure is made up of solution storage box, artificial lung filtering container, peristaltic pump, ultrasonic device for measuring, organ storage box, pH meter container and control circuit.
The flow direction order of solution is: new liquid storage box-> artificial lung filtering container-> import peristaltic pump (the first peristaltic pump)-> ultrasonic device for measuring-> organ storage box->pH counts container-> outlet peristaltic pump (i.e. the second peristaltic pump)-> and used solution storage box; Solution storage box comprises the new liquid storage box of solution and uses storage box, and both open with dividing plate resistance; PH meter container comprises pH meter measuring vessel and pH meter clean container, and wherein pH meter measuring vessel is for measuring solution ph, and pH meter clean container is used for glass electrode fixed time cleaning, and pH meter is connected to two containers by mechanical arm and switches.
Described status monitoring regulation and control module, its structure is made up of temperature sensor, hydraulic pressure sensor, pH sensor, organ storage box, monitor, control panel, compressor set and control circuit.Monitor & control panel (MCP) adopts touch-screen to realize, and is placed in instrument upper surface; Compressor set is made up of compressor, condenser, radiator, is placed in instrument internal bottom, for refrigeration (heating).Described GPS locating module, its structure is by gps antenna, and control circuit and monitor form.
See Fig. 1 and Fig. 3, described organ infusion module, its implementation method comprises the steps:
Steps A, utilize the temperature value of temperature acquisition sensor assembly (such as JHL-506 temperature sensor) to compensate the velocity of sound, velocity of sound compensation formula is as follows, and wherein c is the spread speed of ultrasonic in solution medium, and T is solution temperature:
c＝1449.2+4.632T-0.054T
2
Wherein JHL-506 temperature sensor provides 11 megadyne temperature degrees of data, and first transmission package comprises high 3 bit data, and second transmission package comprises least-significant byte data, and DSP adopts interrupt mode reading temperature data.By the temperature data accounting temperature value read, if temperature value is between-10 DEG C to 60 DEG C, and differ with the temperature value read last time when being less than 1 DEG C, upgrade the variable of storage temperature value, as the confirmation of next temperature reading correct comparison.If temperature value is outside-10 DEG C ~ 60 DEG C, or be greater than 1 DEG C with the difference of the temperature value read last time, illustrate and read error in data, do not upgrade the variable of storage temperature value, only this result is read correct comparison as next temperature and confirm.If continuous 5 times are read error in data, then this sensor is judged to be fault, does troubleshooting, improve the antijamming capability of system.
Step B, in conjunction with velocity of sound offset, utilizes ultrasonic method of measuring to survey solution flow rate and flow, and is shown by monitor, and wherein ultrasonic method of measuring is surveyed flow rate of liquid formula and is:
Wherein, υ is for recording solution flow rate, and L is the line distance of ultrasonic transmitter-receiver, and θ is the sharp angle of transmitter-receiver line and catheter, and c is the propagation rate of ultrasonic in solution medium, and Δ t is the difference of adverse current time and following current time.According to the energy ezpenditure of liver organ, primer solution minimum flow velocity computing formula is as follows:
Wherein, V is the amount of liver organ average minute clock consumed energy (nutriment), and η is energy (nutriment) concentration in the solution, and S is the cross-sectional area of catheter, therefore υ>=υ
sensure that isolated organ can keep sealing active prerequisite for a long time.
Step C, dsp chip is according to flow-control stepper motor rotating speed, drive and import and export two peristaltic pump work, compare with timer by arranging register modulation value, produce pulse width modulation (PWM) signal consistent with setting value, namely by the cycle control step pulse frequency of control DSP timer, and then control motor speed, rotating speed formula is as follows:
ω＝θ
N×f
Wherein, θ
nfor stepping motor single pulse steering angle, f is step-by-step impulse frequency, imports and exports the stepping motor synchronous work of two peristaltic pump, jointly realizes solution injection process.In this device, stepper motor often turns 1 degree, and runner turns over 0.96 millimeter, therefore minimum pulse frequency f
sbe calculated as follows:
The cycle control step pulse frequency of control DSP timer, makes f>=f
s, then solution flow rate meets the demands, and realizes isolated organ infusion, wherein DSP infusion modular algorithm step: 1) initialize; 2) minimum flow rate of liquid is calculated; 3) minimum pulse frequency is calculated; 4) stepper motor exports pwm pulse; 5) ultrasonic meter collection liquid flow velocity utilize monitor to show; 6) upgrade.
See Fig. 1 and Fig. 4, described status monitoring regulation and control module, its implementation method comprises the steps:
Steps A, sensor Collect conversion: compare type serial a/d converter ADC08B200 chip and under the clocked flip of DSP2812 controls, flow resistance and pH value transformation result are preserved, and utilize interruption to read high accuracy number temperature sensor JHL-506 temperature (precision is ± 0.1 DEG C).Wherein the installation site of n piece of temperature sensor JHL-506 is the wall of organ storage box, is l with the distance of isolated organ
1, l
2..., l
n, it is T that respective sensor records temperature
1, T
2..., T
n, then temperature residing for isolated organ is:
Wherein a
1=l
2l
3l
n, a
2=l
1l
3l
n..., a
n=l
1l
2l
n-1, can find out, sensor and isolated organ are apart from nearer, its factor of influence is larger, and when certain sensor and isolated organ distance are 0, its measured value is actual value, single-sensor reading manner and infusion module are consistent, and every 100 milliseconds upgrade a temperature value.Hydraulic pressure sensor and pH combination electrode sensor adopt Interruption to read, and arrange DSP timer 0 Interruption and within every 10 seconds, complete the renewal of primary transducer data startup Collect conversion; DSP timer 1 Interruption every 300 seconds driving mechanical arms are set and complete pH combination electrode sensor cleaning operation.
Step B, touch-screen is read and write: utilize ADS7843 chip controls color touch to shield monitor & control panel (MCP), utilizes serial ports send control word and read voltage conversion value; The read-write of ADS7843 utilizes software programming implement of interruption function.Wherein, interrupt control procedure to comprise: 1) read ADS7843: the button configuration information being mainly touch-screen, comprise numerical value and increase progressively 1 unit, number decrements 1 unit, pattern setting, precision setting etc.; 2) ADS7843 is write: be mainly solution flow rate, liquid resistance, temperature and GPS locating information that sensor records, because the update cycle of often kind of information is different, then write ADS7843 chip by single channel timesharing, information header is distinguished by 00,01,10,11 marks.
Step C, compressor exports and controls: employing PWM controller produces the adjustable pwm control signal that dutycycle is 10% ~ 100%, controls the change of frequency of direct current compressor, thus fine adjustment refrigeration (heating) amount.Control to realize PWM, first a metric counter will be designed, clock rate C LK elects 100MHz as, EN enable signal is controlled by DSP2812 simultaneously, rising edge triggers, and utilize counter equal dutycycle, comparator compares renewal dutycycle, latch exports the design that pulse completes PWM controller, and then controls compressor speed.
Temperature-fall period double-compressor works simultaneously at full speed, thermostatic process single compressor discontinuous operation.According to the study, the best storage temperature of isolated organ is 4 DEG C, now can not only avoid direct frost damage, and greatly reduce histiocytic energy metabolism level, improve and organize anti-ischemic ability, therefore DSP controls the temperature constant state that compressor should be maintained at 4 DEG C, compressor cooling heats conversion and switches to change refrigerant flow direction realization by cross valve.
See Fig. 1 and Fig. 5, described GPS locating module, relate to signal capture algorithm, carrier track algorithm, code tracking algorithm, satellite position resolve, customer location resolves scheduling algorithm, complexity and operand is large, for meeting GPS positioning precision and real-time, adopt DSP and FPGA combination of hardware mode, its implementation method comprises the steps:
Steps A, obtains view of time by external interrupt and measures and navigation message, and both spliced;
Step B, measures pseudo-range information by time observation, is calculated the position in satellite launch moment, comprise the information such as observation satellite three-dimensional position, the elevation angle and azimuth by navigation message;
Step C, the ephemeris according to observation satellite is revised pseudorange, and carries out ionosphere and tropospheric correction;
Step D, according to positioning principle, calculates the three-dimensional position of user, corrects local zone time, and converts positional information to required coordinate format, shown by monitor.
See Fig. 6, described temperature section control algolithm, its embodiment is: during instrument normal condition, and temperature ring adjuster adopts large temperature difference refrigeration at full speed, the Discrete control method that little temperature difference PID (PID) regulates; When the temperature difference is larger, double-compressor full speed operation, makes system temperature the fastest close to setting value; When the temperature difference is less than critical value, single compressor adopts PID to regulate, and final updating PWM dutycycle, to regulate the rotating speed of compressor.
Wherein, PID controller is a kind of linear controller, by proportional unit P, integral unit I and differentiation element D forms, control deviation is formed with real output value y (t) according to given temperature value r (t), the control law of e (t)=r (t)-y (t), PID is:
In formula, K
pfor proportionality constant, T
ifor integration time constant, T
dfor derivative time constant, it adopts aritical ratio method to carry out parameter tuning, as follows: 1) select enough short sampling period allow system works; 2) only additional proportion controlling unit, until there is threshold oscillation in the step response of system to input, record rate mu-factor and critical period of the oscillation; 3) proportionality constant of PID controller is calculated, integration time constant and derivative time constant.
See Fig. 7, in actual measurement process, adjusted by pid parameter, when set temperature is 4 DEG C, its overshoot of temperature is less than 2% (± 0.08 DEG C), and regulation time is less than 0.2s, and steady-state error is less than 5% (± 0.2 DEG C); Of the present invention preserve for isolated organ high precision controller constant temp full speed operation time, temperature convergence speed be 1 DEG C per minute (the long 400-500mm of instrument outside dimension, wide: 300-400mm, high: 600-700mm); Monitor touch screen interface of the present invention, comprise state, history, setting, prompting 4 setting, wherein " state " is for inquiring about the every Information Monitoring of current time, " history " is for inquiring about last time every terms of information, " setting " is for arranging precision, pattern etc., " prompting " is for Information abnormity warning etc., visible, which overcome traditional frozen water and preserve energy loss, the defect of organ damage, and in conjunction with pH value detection, the detection of solution flow rate resistance, GPS location etc., the more Kubo contributing to isolated organ is deposited and is transported.
In a word, the present invention adopts DSP to realize solution Continuous Perfusion, status monitoring regulation and control and instrument GPS positioning control function, solution Continuous Perfusion contributes to improving receptor survival rates, increases graft oxygen supply during preservation, improve graft fill with again after energy metabolism; Status monitoring regulation and control contribute to maintaining the physiological parameter relative constancy such as organ storage box temperature, pH value; Instrument GPS is positioned with and helps isolated organ and accurately transport, and selects optimal path, saves the shipping time.
More than describe the preferred embodiment of the present invention in detail; but the present invention is not limited to the detail in above-mentioned embodiment, within the scope of technical conceive of the present invention; can carry out multiple equivalents to technical scheme of the present invention, these equivalents all belong to protection scope of the present invention.It should be noted that in addition, each the concrete technical characteristic described in above-mentioned embodiment, in reconcilable situation, can be combined by any suitable mode.In order to avoid unnecessary repetition, the present invention illustrates no longer separately to various possible combination.In addition, also can be combined between various different embodiment of the present invention, as long as it is without prejudice to thought of the present invention, it should be considered as content disclosed in this invention equally.
Claims (5)
1. an isolated organ High Accuracy Constant Temperature perfusion instrument, is characterized in that, comprising: organ infusion module, monitoring module and GPS locating module, wherein,
Described organ infusion module comprises control unit, the new liquid storage box be sequentially communicated with, artificial lung filtering container, the first peristaltic pump, organ storage box, pH meter container, the second peristaltic pump and used liquid storage box, and the temperature sensor acquisition module, ultrasonic measurement module, display translation module and the stepper motor that are electrically connected with described control unit; Described stepper motor and the first peristaltic pump and the second peristaltic pump are in transmission connection, and described temperature sensor acquisition module is arranged in organ storage box, and described ultrasonic measurement module is for measuring the solution flow rate in catheter;
Described monitoring module comprises the hydraulic pressure sensor, pH meter, compressor and the driven compressor module that are electrically connected with described control unit, and the signal of described hydraulic pressure sensor and pH meter is by sending into described control unit after A/D converter conversion;
Described GPS locating module comprises gps antenna and FPGA module, and described FPGA module is electrically connected with described control unit.
2. isolated organ High Accuracy Constant Temperature perfusion instrument as claimed in claim 1, it is characterized in that, the process that organ perfusion's module controls rate of flooding is as follows:
Step 1A, utilize the temperature value of temperature sensor acquisition module to compensate the velocity of sound, velocity of sound compensation formula is as follows, and wherein c is the spread speed of ultrasonic in solution medium, and T is solution temperature:
c＝1449.2+4.632T-0.054T
2
Step 1B, to compensate in conjunction with the velocity of sound, utilize ultrasonic method of measuring to survey solution flow rate and flow, and shown by monitor, wherein ultrasonic method of measuring is surveyed flow rate of liquid formula and is:
Wherein, υ is for recording solution flow rate, and L is the line distance of ultrasonic transmitter-receiver, and θ is the sharp angle of transmitter-receiver line and catheter, and c is the spread speed of ultrasonic in solution medium, and Δ t is the difference of adverse current time and following current time;
Step 1C, control unit, according to flow-control stepper motor rotating speed, drive first, second pair of peristaltic pump work, and compare with timer by arranging register modulation value, produce the pulse width modulating signal consistent with setting value, rotating speed formula is as follows:
ω＝θ
N×f
Wherein, θ
nfor stepping motor single pulse steering angle, f is step-by-step impulse frequency, and the stepping motor synchronous work of first, second pair of peristaltic pump, realizes solution injection process jointly.
3. isolated organ High Accuracy Constant Temperature perfusion instrument as claimed in claim 1, is characterized in that, the process of monitoring module Monitoring and Controlling perfusion instrument is as follows:
Step 2A, utilizes A/D converter that the analog signal of hydraulic pressure sensor and pH meter collection is converted to data signal to schedule, preserves; Reading temperature data, preserves;
Step 2B, by touch-screen receiving control information;
Step 2C, controls compressor power output by PWM controller, controls the change of frequency of direct current compressor, thus fine adjustment refrigerating capacity or heating capacity.
4. the isolated organ High Accuracy Constant Temperature perfusion instrument as described in any one of claims 1 to 3, is characterized in that, the process of described GPS location is as follows:
Step 3A, obtains view of time by external interrupt and measures and navigation message, and both spliced;
Step 3B, measures pseudo-range information by time observation, is calculated the position in satellite launch moment, comprise observation satellite three-dimensional position, the elevation angle and azimuth by navigation message;
Step 3C, the ephemeris according to observation satellite is revised pseudorange, and carries out ionosphere and tropospheric correction;
Step 3D, according to positioning principle, calculates the three-dimensional position of user, corrects local zone time, and converts positional information to required coordinate format, shown by monitor.
5. isolated organ High Accuracy Constant Temperature perfusion instrument as claimed in claim 1, it is characterized in that, described pH meter container comprises pH meter measuring vessel and pH meter clean container, described pH meter measuring vessel is for measuring the pH value of solution, described pH clean container is used for fixed time cleaning glass electrode, and pH meter is switched between two containers by mechanical arm.
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| CN110583620A (en) * | 2019-08-26 | 2019-12-20 | 广东顺德工业设计研究院(广东顺德创新设计研究院) | Temperature adjusting device, method and device for mechanical perfusion of isolated lung |
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| CN112273370A (en) * | 2020-09-27 | 2021-01-29 | 中山大学附属第一医院 | Intelligent isolated organ perfusion regulation and control device and method |
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| CN104186459A (en) * | 2014-08-07 | 2014-12-10 | 中国人民解放军第三〇九医院 | Sub-normal-temperature or low-temperature isolated kidney storage device |
| CN104705288A (en) * | 2015-02-16 | 2015-06-17 | 杭州电子科技大学 | Sub normal temperature transplanted organ extracorporal intelligent support system and method |
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2015
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104186459A (en) * | 2014-08-07 | 2014-12-10 | 中国人民解放军第三〇九医院 | Sub-normal-temperature or low-temperature isolated kidney storage device |
| CN104705288A (en) * | 2015-02-16 | 2015-06-17 | 杭州电子科技大学 | Sub normal temperature transplanted organ extracorporal intelligent support system and method |
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