CN105120910B - 用于在医疗器械内原位形成材料的方法 - Google Patents

用于在医疗器械内原位形成材料的方法 Download PDF

Info

Publication number
CN105120910B
CN105120910B CN201480015060.9A CN201480015060A CN105120910B CN 105120910 B CN105120910 B CN 105120910B CN 201480015060 A CN201480015060 A CN 201480015060A CN 105120910 B CN105120910 B CN 105120910B
Authority
CN
China
Prior art keywords
aqueous solution
initiator
solution
inflatable element
radical initiator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480015060.9A
Other languages
English (en)
Other versions
CN105120910A (zh
Inventor
C·班克特
P·门多萨
S·施雷克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Endorojex LLC
Original Assignee
Endologix LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endologix LLC filed Critical Endologix LLC
Publication of CN105120910A publication Critical patent/CN105120910A/zh
Application granted granted Critical
Publication of CN105120910B publication Critical patent/CN105120910B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12136—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/143—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Polymers & Plastics (AREA)
  • Polymerisation Methods In General (AREA)
  • Surgical Instruments (AREA)

Abstract

描述了用于通过如下方式在原位医疗器械中形成材料的方法：在将可聚合溶液从其储存容器转移到原位医疗器械内的空间的过程中或者之后，引发水性溶液中的水溶性聚合物前体的聚合。储存的具有水溶性前体的水性溶液不含自由基引发剂，在水性溶液被转移到原位医疗器械内部的空间的过程中或之后，所述自由基引发剂以粉末形式被引入到水性溶液中。该储存和递送***为储存的水性溶液提供更好的稳定性，使其能够储存在环境温度下，并相对于现有原位聚合体系中所用的溶液提供延长的保存寿命。仅仅对一种水性溶液进行储存和递送/传输的灵活性而不是需要使用两种不同溶液，也是一个好处。

Description

用于在医疗器械内原位形成材料的方法
背景技术
本申请要求2013年3月14日提交的题为“Method for Forming Materials InSitu Within a Medical Device(用于在医疗器械内原位形成材料的方法)”的美国临时专利申请第61/785,445号的优先权，其全文通过引用结合入本文。
腹部腹主动脉瘤(AAA)是在主动脉中的弱化区域，其在接近腹部区域形成球状凸出或囊。随着血液流动通过主动脉，血压推压弱化壁，导致其扩张并且常常破裂。破裂的AAA在美国是一个主要死亡原因。
过去，夹具和开放性手术是用于AAA的传统介入疗法。近来，将移植物(有时出于增加稳定性具有支架)放置在动脉瘤上，以降低动脉瘤壁上的压力并防止其发生扩张和破裂。
最近，描述了这样的***，其中，通过微创外科手术(MIS)技术的方式，将器械的可膨胀元件引入到动脉瘤囊中，例如采用出于该目的引入患者内的导丝，指引通过人体患者的脉管***。将可流动前体材料引入可膨胀元件中，前体材料发生化学反应并引起可膨胀元件的膨胀并与动脉瘤囊的形状相一致。随着材料硬化，它们将可膨胀材料固定在患者体内的适当位置并使得动脉瘤稳定化。参见例如，美国专利公开第7,872,068号和第8,044,137号，以及U.S.2006/0222596，其全文通过引用结合入本文。可膨胀元件可以是例如单壁或双壁气球或者可充气套囊。提供了具有可充气或可膨胀元件的器械的其他例子，例如，参见PCT申请公开号WO 00/51522，美国专利公开号5,334,024、5,330,528、6,1312,462、6,964,667、7,001,431、2004/0204755和2006/0025853A1，其全文通过引用结合入本文。可流动前体材料通常是聚合物前体，其聚合并交联以形成水凝胶。一种优选类型的聚合物前体是能够通过自由基聚合发生聚合的材料。通常，这涉及两种预聚物的聚合/交联，它们分别具有末端反应性基团，其易于发生自由基聚合，例如丙烯酸酯和甲基丙烯酸脂。
通过将两种预聚物与热活化的低温自由基引发剂和引发剂催化剂在生理温度下结合，来实现聚合。
为了避免过早聚合，即在所有组分混合并使得它们在可膨胀器械内原位聚合之前，通常将组分储存在两种分开的水性溶液中，一种溶液包含一种聚合物前体和自由基引发剂，另一种溶液包含另一种聚合物前体和引发剂催化剂。以这种方式，将两种聚合物前体保持分开，也将自由基引发剂和引发剂催化剂保持分开。
在实践中，两种溶液同时递送然后混合，在歧管中离体或者是在可膨胀器械自身中。
由于热活化的低温自由基引发剂的不稳定性，含组分的溶液必须一定要保持冷冻，即零摄氏度或更低，直至使用。即使如此，器械或者包含此类溶液的试剂盒的可用保存寿命也仅有12-18个月。
必须将溶液保持冷冻是一个严重的实践缺陷，因为溶液无法容易地解冻并当具有AAA的患者需要立即处理时尽快地待用，特别是由于引发剂的热活化导致无法使用采用大温差的常规技术(例如热水或微波解冻)来进行快速解冻。
会希望具有这样的材料和用于此类材料的方法，使得用于处理的水性溶液可以储存在环境温度或者接近环境温度，实现当需要时的立即使用，并且具有至少2年的可用保存寿命。
还会希望能够仅给药一种溶液而不是两种，从而避免在歧管或其他装置中进行混合并确保聚合的材料的均匀性的必要性。
发明内容
需要的是一种使得AAA治疗器械稳定化的改进方法。本文描述了这些方法，包括使得植入医疗器械稳定化的材料和方法，通过引入可流动前体材料，所述前体材料使得器械的可膨胀元件膨胀以将器械固定到位，然后前体硬化以将器械保持到位。先前的器械和方法详细参见例如上文所引用的美国专利第8,044,137号，其全文通过引用结合入本文。
本文所述的实施方式提供了这样的方法，其实现了植入的医疗器械的更简单且更实用的稳定化，特别是消除了保持材料冷冻直至使用的需求，增加了保存寿命，并且能够仅使用一种溶液来引发过程。
具体来说，一种实施方式涉及通过增加患者体内的医疗器械的可膨胀元件的体积，来原位形成材料的方法，其包括：
a.将可流动水性溶液引入到与可膨胀元件内部空间连通的管中，或者直接引入到可膨胀元件中，所述可流动水性溶液包含第一和第二水溶性聚合物前体以及任选的引发剂催化剂，每种水溶性聚合物前体具有末端官能团，
b.将粉末形式的热活化的低温自由基引发剂引入到步骤(a)的可流动水性溶液中，
c.使得自由基引发剂在可流动水性溶液中溶解，
d.如果没有在步骤(a)中预先引入的话，则将引发剂催化剂引入步骤(c)的溶液中，以及
e.使得聚合物前体上的官能团发生共价键合，以在可膨胀元件内的空间中形成固态且基本不可生物降解的材料。
可流动水性溶液可由第一和第二源溶液的混合物形成，它们分别被引入到分开的填充管中，每种源溶液包含一种聚合物前体，或者如果采用同时包含第一和第二聚合物前体的仅仅一种源溶液，则可流动水性溶液与所述一种源溶液相同，并引入到单个填充管中。催化剂可存在于源溶液中，或者在引入引发剂之前或之后添加。
该方法实现了使得引入的源溶液不含自由基引发剂，作为替代，自由基引发剂保持粉末形式，并仅在需要聚合的时候引入到可流动水性溶液中。该粉末形式的材料可存在于可膨胀元件上游的滤器中，存在于可膨胀元件自身，或者存在于与可膨胀元件连通的容器中。作为源溶液中不存在自由基引发剂的结果，可以并且希望在一种源溶液中结合两种聚合物前体，从而给药单种源溶液以引发聚合过程。
附图说明
图1显示现有技术设备的示意性截面图。
图2A显示滤器单元的一个实施方式的示意性截面图。
图2B显示滤器单元的另一个实施方式的示意性截面图。
图2C显示集成歧管/滤器单元的一个实施方式的示意性截面图。
图3显示可膨胀元件的一个实施方式的示意性截面图。
图4显示用于实施本文所述方法的设备的一个实施方式的示意性截面图。
图5显示用于实施本文所述方法的设备的另一个实施方式的示意性截面图。
图6显示用于实施本文所述方法的设备的另一个实施方式的示意性截面图。
图7显示图6的可膨胀元件的封闭示意性截面图。
图8显示用于实施本文所述方法的设备的另一个实施方式的部分示意性截面图。
附图旨在描述各组件及其相互关系。组件不是按比例绘制的。
具体实施方式
如上所述，先前用于治疗AAA的方法包括通过增加医疗器械的可膨胀元件的体积，来原位形成材料。当通过可流动材料使得可膨胀元件发生膨胀时，可膨胀元件与装纳其的动脉瘤的形状一致，并且一旦硬化，将医疗器械固定到位。通过水性溶液中的两种聚合物前体，在存在热活化的自由基引发剂和引发剂催化剂的情况下的自由基聚合，来形成材料。在例如，包含单壁或双壁气球的植入物内进行聚合。
图1显示用于实施先前方法的典型现有技术设备10的实施方式。两种溶液13A、13B位于容器11A、11B中，例如注射器，其与填充管12A、12B连通。在该构造中，一种溶液包含第一聚合物前体以及引发剂或催化剂，另一种溶液包含第二聚合物前体以及引发剂和催化剂中的另一种。将溶液13A、13B加压递送到歧管16，它们在其中混合。歧管可包括各种结构以确保完全混合。然后将所得到的溶液递送通过管14到达可膨胀元件15，在其中进行聚合，可膨胀元件发生膨胀，与围绕的动脉瘤(未示出)的形状相一致，随时间的推移进行聚合。一旦结束溶液递送(溶液注入的终止可以基于与加压管(例如管14)附连的压力传感器，或者可以基于对所需占据的动脉瘤空间进行填充所需的预测量或计算体积所实现的递送)，则可以将管14从可膨胀元件撤回，实现将聚合化的混合物密封在可膨胀元件15内。通常通过导丝上放到位的导管的方式，将包含可膨胀元件的医疗器械递送到患者体内的动脉瘤的位置。在另一个实施方式中，不存在歧管，两种溶液在可膨胀元件中混合。
在待引入的一种溶液中存在引发剂的问题在于，溶液(因而整个设备)需要保持冷冻，并且仅在紧接递送到导管对患者进行治疗之前才解冻。涉及大温差，例如热水或微波处理的常规方式的解冻是不可行的，这是由于引发剂的热活化导致的。在环境温度下，溶液中的引发剂是不稳定的，会导致聚合物前体的降级，例如和包括过早聚合，导致不可接受的保存寿命。
现在令人惊讶的发现，通过消除溶液中的引发剂并在稍后过程中将其以粉末形式引入，(i)可以避免将含有溶液的设备储存在冷冻温度；(ii)可以改善整体保存寿命；(iii)可以将两种聚合物前体结合在一种溶液中进行递送，极大地简化了工艺；以及(iv)所得到的水凝胶的质量与通过先前方法制备的质量基本相同。
因此，在其最宽方面，描述的方法包括通过增加患者体内的医疗器械的可膨胀元件的体积，来原位形成材料的方法，其包括：
a.将可流动水性溶液引入到与可膨胀元件内部空间连通的管中，或者直接引入到可膨胀元件中，所述可流动水性溶液包含第一和第二水溶性聚合物前体以及任选的引发剂催化剂，每种水溶性聚合物前体具有末端官能团，
b.将粉末形式的热活化的低温自由基引发剂引入到步骤(a)的可流动水性溶液中，
c.使得自由基引发剂在可流动水性溶液中溶解，
d.如果没有在步骤(a)中预先引入的话，则将引发剂催化剂引入步骤(c)的溶液中，以及
e.使得聚合物前体上的官能团发生共价键合，以在可膨胀元件内的空间中形成固态且基本不可生物降解的材料。
特别优选的聚合物前体是如下那些，在聚合和交联之后，会导致具有某些所需性质的水凝胶，特别是可溶胀性小于约20％v/v且杨氏模量至少约为100千帕的固态且不可生物降解的材料。为了使得MIS(微创外科手术)过程所需的时间最小化，但是时间足以从可膨胀元件去除填充管，优选形成最终的水凝胶的时间约为30秒至约30分钟，从引发聚合反应开始。通过溶液中的两种聚合物前体、引发剂和催化剂，来引发聚合反应。
优选聚合物前体是水溶性的，相互可溶，具有类似的聚合反应性，以确保水凝胶是无规共聚物并具有末端官能团。特别优选的是如下聚合物前体，其包含聚环氧乙烷单元(即聚乙二醇(PEG))，具有末端丙烯酸酯或甲基丙烯酸酯官能团。还优选第一聚合物前体是线型的，第二聚合物前体是支化的。线型聚合物前体为水凝胶提供长链、耐用和灵活基础，支化聚合物前体为水凝胶提供高度交联，其具有含所需可溶胀性和硬度的网络结构。特别优选的线型聚合物前体是聚乙二醇，其末端衍生有2个丙烯酸酯基团并具有约20-50千道尔顿(最优选约35千道尔顿)的分子量。特别优选的支化聚合物前体是低聚支化聚乙二醇，其末端衍生有3个丙烯酸酯基团并具有约800道尔顿至1.2千道尔顿(最优选约1千道尔顿)的分子量。支化聚合物前体与线型聚合物的摩尔比优选约为200:1至1000:1，最优选约400:1。
热活化的低温自由基引发剂会在生理体温或接近生理体温引发自由基交联反应。特别优选的引发剂是过硫酸钠、过硫酸钾和过硫酸铵。过硫酸铵是特别优选的原因在于它的高水溶性，从而确保其在所述过程中的完全溶解性。
引发剂催化剂用于通过与引发剂反应来引发聚合反应。优选的催化剂包括三乙醇胺和四甲基乙二胺。三乙醇胺是特别优选的。通常优选引发剂与催化剂以约等摩尔量存在，支化聚合物前体与引发剂的摩尔比约为2:1至约15:1，优选约7:1。
前述组分(两种聚合物前体，以及任选的催化剂)溶解在一种或两种源溶液中，优选溶解在缓冲的水性溶液中，例如磷酸盐缓冲溶液，其具有对于酯键的稳定性是合乎希望的pH，优选中和至略酸性，pH 4-7，并且提供相对于生理条件具有中性渗透压的水凝胶。稍后使得作为粉末的引发剂溶解。充分缓冲的源溶液被用于降低粘度并确保源溶液是可流动的。如果采用两种源溶液，则第一源溶液包含第一聚合物前体，第二源溶液包含第二聚合物前体。催化剂可以存在于源溶液之一中，或者其可以稍后添加，在引入引发剂之前或之后。优选地，催化剂存在于源溶液之一中。此外，源溶液之一通常还包含辐射阻挡(radio-opaque agent)试剂，例如用于荧光显影的泛影酸钠(sodium diatrizoate)。为了易于递送，优选采用约为等体积的两种源溶液。如果仅采用一种源溶液，则存在两种聚合物前体、任选的催化剂以及辐射阻挡试剂。优选地，催化剂存在于源溶液中。
在如图2A所示的一个实施方式中，滤器单元20A包括滤器18。将粉末形式的引发剂17A布置在滤器的上游侧。滤器单元布置在可膨胀元件的上游的管14中。随着可流动水性溶液通过滤器单元，引发剂溶解在其中。
在另一个实施方式中，粉末形式的引发剂17B固定在滤器18的上游侧上。这如图2B所示。可以通过例如将引发剂俘获在海绵或支架中，将其捕集在小孔中或者易蚀固体中，来实现固定。
在如图2C所示的另一个实施方式中，利用两种源溶液，显示将歧管和滤器集成在单个单元20C中。
在图2A-C的前述实施方式中，滤器可以由PTFE、PVDF、聚砜、聚丙烯和其他相容材料构成，其具有足够小的孔，以防止引发剂粉末通过其，但是能够允许溶液在压力下的通过而不造成阻碍。箭头显示流动方向。可以使用各种具有上述性质的市售可得的滤器单元，例如33mm Millex GP 0.22μm滤器。
在如图3所示的另一个实施方式中，粉末形式的引发剂17C布置在可膨胀元件15中。然后，当可流动水性溶液流入可膨胀元件中时，该材料溶于可流动水性溶液中。
用于实施所述方法的设备40的一个实施方式如图4所示。将两种源溶液19A、19B(其分别含有一种聚合物前体，一种源溶液包含催化剂)递送到歧管16，然后将所得到的可流动水性溶液递送到滤器18，所述滤器18具有以粉末形式布置在其上游侧的引发剂17A(或17B)，在粉末溶解之后，所得到的溶液通过滤器并被递送到可膨胀元件15。
用于实施所述方法的设备50的另一个实施方式如图5所示。在该实施方式中，仅采用一种源溶液21。该溶液同时包含两种聚合物前体和催化剂，并且被递送到滤器18，所述滤器18具有以粉末形式布置在其上游侧的引发剂17A(或17B)，在粉末溶解之后，所得到的溶液通过滤器并被递送到可膨胀元件15。
用于实施所述方法的设备60的另一个实施方式如图6所示。将单个源溶液直接递送到可膨胀元件15，其显示为部分膨胀。将小部分(例如5-10％)体积的递送的溶液26通过管22撤回到含有粉末形式的引发剂17D的容器23(例如注射器)中。在粉末溶解于递送的溶液26之后，所得到的溶液通过管22返回到可膨胀元件中，与可膨胀元件中递送的溶液26混合，使得进行聚合反应。在该实施方式的变化形式中，初始地将两种源溶液递送到可膨胀元件。
图7显示图6的可膨胀元件15在含引发剂的溶液通过管22返回之后的具体实施方式。所得到的溶液24发生聚合。为了确保含引发剂的返回溶液与递送的溶液26在可膨胀元件中的完全混合，管22的远端部分显示为延伸基本到达可膨胀元件的远端。还显示管22的远端部分具有绕着管22的远端部分环状间隔开的多个端口25。以这种方式，通过管22返回的溶液可以与递送的溶液26更完全的混合，以确保更均匀混合的溶液，并得到具有所需性质的均匀水凝胶聚合物。
如上文所述，催化剂可以被结合到源溶液中或者在稍后过程中引入(在引入引发剂之前或之后)。图8显示用于实施本发明的设备80的一个实施方式。在该实施方式中，两个滤器单元20A和27串联连接。滤器单元20A含有引发剂17A(或17B)，滤器单元27含有催化剂29。同时包含两种聚合物前体的可流动水性溶液流入滤器单元20A，在其中使得引发剂溶解于其中，然后流入滤器单元27，在其中使得催化剂29溶解于其中，之后递送到可膨胀元件15。在该实施方式的一个变化形式中，两个滤器单元的位置发生调换，使得将催化剂引入到可流动水性溶液中，然后引入引发剂。用于催化剂的滤器单元可以与用于引发剂的滤器单元是相同类型的。
以下实施例仅出于说明目的，并不旨在以任意方式限制其他实施方式的范围。
实施例1
通过如下方式制备第一源溶液：混合约为等重量的0.01M、pH 7.0的磷酸盐缓冲液和乙氧基化(20)三羟甲基丙烷三丙烯酸酯(PEG-T)(美国宾夕法尼亚州埃克斯顿市沙多玛公司(Sartomer Co.,Exton,PA))。通过如下方式制备第二源溶液：在0.01M、pH 7.0的磷酸盐缓冲液中含有4％(w/w)的聚乙二醇二丙烯酸酯35,000Da(PEG-D)(美国德克萨斯州艾伦市键凯科技公司(JenKem Technology,Allen,TX))。分别将22-23mL的这些源溶液转移到封顶双筒注射器的单独的平行室内。将38g的过硫酸铵粉末(APS)置于33mm Millex GP 0.22μm滤器碟的入口侧上，敲打该碟以使得粉末更好地分布。将55mg的三乙醇胺液体(TEA)置于第二33mm Millex GP 0.22μm碟的入口侧上。将多元素静态混合器与双筒注射器的端部相附连。双筒注射器放入分配设备中，其能够分配等体积的两种溶液通过混合器。将含有APS的滤器与混合器附连，依次将含有TEA的滤器与APS滤器的出口相连。每种源溶液分配约15mL(总计30mL)，耗时10-20秒，通过混合器以及两个滤器，随后进入置于37摄氏度水浴中的3玻璃瓶中，每个瓶中约10mL。在7分钟后，在第一个瓶中观察到聚合，产生白色固体水凝胶。
实施例2
将等体积(分别约为25mL)的实施例1的第一和第二源溶液进行混合，以形成单个源溶液。由于仅有封顶双筒注射器可用，将所得到的单个源溶液转移到注射器的两个平行室，每个约22-23mL，将混合管与注射器相连，目的不是进行混合，而是提供合适的连接器。将含有27mg的TEA液体的33mm Millex GP 0.22μm滤器碟与混合管的端部附连，并依次将含有32mg的APS粉末的第二33mm Millex GP 0.22μm滤器碟与第一滤器的出口相附连。双筒注射器放入分配设备中，其能够分配等体积的两种溶液。每个筒分配约15mL(总计30mL)，耗时10-20秒，通过滤器，随后进入置于37摄氏度水浴中的3玻璃瓶中，每个瓶中约10mL。在9分钟后，在第一个瓶中观察到聚合，产生白色固体水凝胶。
实施例3
重复实施例1，不同之处在于，滤器颠倒，从而使得具有TEA的滤器与混合器的端部相附连，而具有APS的滤器依次与第一滤器的出口相附连。观察到聚合，产生白色固体水凝胶。
实施例4
重复实施例2，不同之处在于，滤器颠倒，从而使得具有APS的滤器与混合管的端部相附连，而具有TEA的滤器依次与第一滤器的出口相附连。观察到聚合，产生白色固体水凝胶。
实施例5
重复实施例1，不同之处在于，将92mg的TEA溶解在第一源溶液中，而不是装纳在滤器中。观察到聚合，产生白色固体水凝胶。
实施例6
重复实施例2，不同之处在于，将45mg的TEA溶解在单个源溶液中，而不是装纳在滤器中。观察到聚合，产生白色固体水凝胶。
实施例7
通过将4.8g的PEG-D和2.4g的泛影酸钠溶于112.8g的0.01M、pH 5.0的磷酸盐缓冲液中，来制备第一源溶液。通过将64.2g的PEG-T和1.128g的三乙醇胺溶于64.8g的0.01M、pH5.0的磷酸盐缓冲液中，来制备第二源溶液。将2.009g的过硫酸铵置于聚氨酯植入袋的内部。将60mL的每种源溶液混合15分钟，以形成单一源溶液。源溶液置于注射器中，并在21摄氏度下注入置物袋内，没有进行搅动以使得水凝胶固化。在22分钟24秒之后观察到完全聚合，产生固体白色水凝胶。
根据本发明的前述实施方式以及用于实施此类实施方式的设备仅是示意性的，并不旨在限制下文所附的权利要求书的范围。上述实施方式的变化、改进和组合对于本领域技术人员是显而易见的，并且包括在本发明中。

Claims (23)

1.一种用于治疗患者体内的动脉瘤的***，所述***包括：
适于递送到患者体内并膨胀的可膨胀元件；
与所述可膨胀元件内的空间流体连通，或者直接导入所述可膨胀元件内的管；
可流动水性溶液，其包含第一和第二水溶性聚合物前体以及任选的引发剂催化剂，每种水溶性聚合物前体具有末端官能团；以及
热活化的低温自由基引发剂，其以粉末形式溶解在所述可流动水性溶液中，如果所述可流动水性溶液不含引发剂催化剂，则将所述引发剂催化剂引入溶液中；
所述溶液和引发剂适于使得所述水溶性聚合物前体上的官能团发生共价键合，以在所述可膨胀元件内的空间中原位形成固态且基本不可生物降解的材料,
其中,所述***还包括：
布置在所述可膨胀元件上游的所述管中的滤器，所述滤器具有上游侧和下游侧；
所述自由基引发剂布置在所述滤器的上游侧上，使得当所述可流动水性溶液通过所述滤器时，所述自由基引发剂溶解在其中。
2.如权利要求1所述的***，其特征在于，所述自由基引发剂固定在所述滤器的上游侧上。
3.如权利要求1所述的***，其特征在于，所述自由基引发剂布置在所述可膨胀元件中，当所述可流动水性溶液进入所述可膨胀元件时，所述自由基引发剂溶解在所述可流动水性溶液中。
4.如权利要求1所述的***，所述***还包括：
与所述可膨胀元件流体连通的容器，所述自由基引发剂布置在所述容器内，所述容器适于使得将一部分的所述可流动水性溶液从所述可膨胀元件撤回进入所述容器中，使得所述自由基引发剂溶解在所述可流动水性溶液中，并且将所得到的混合溶液再次引入到所述可膨胀元件中。
5.如权利要求1所述的***，其特征在于，所述可流动水性溶液是第一和第二源溶液的混合物，所述第一源溶液包含所述第一水溶性聚合物前体，所述第二源溶液包含所述第二水溶性聚合物前体。
6.如权利要求5所述的***，所述***还包括：
歧管，在所述歧管中混合所述第一和第二源溶液，之后与所述自由基引发剂接触。
7.如权利要求6所述的***，其中所述歧管包括集成滤器。
8.如权利要求1所述的***，其特征在于，所述自由基引发剂是过硫酸钠、过硫酸钾或过硫酸铵。
9.如权利要求1所述的***，其特征在于，所述第一水溶性聚合物前体是线型的，所述第二水溶性聚合物前体是支化的。
10.如权利要求9所述的***，其特征在于，所述第一水溶性聚合物前体是线型聚乙二醇，其末端衍生有2个丙烯酸酯基团并具有20-50千道尔顿的分子量，所述第二水溶性聚合物前体是支化低聚聚乙二醇，其末端衍生有3个丙烯酸酯基团并具有800道尔顿至1.2千道尔顿的分子量。
11.如权利要求9所述的***，其特征在于，支化聚合物前体与线型聚合物前体的摩尔比为200:1至1000:1。
12.如权利要求9所述的***，其特征在于，支化聚合物前体与自由基引发剂的摩尔比为2:1至15:1。
13.如权利要求1所述的***，所述自由基引发剂与引发剂催化剂的摩尔比为1:1。
14.如权利要求5所述的***，所述***还包括引发剂催化剂，所述第一或第二源溶液包含所述引发剂催化剂。
15.一种通过增加用于治疗动脉瘤的可膨胀元件的体积来形成植入物的方法，所述方法包括：
a.将可流动水性溶液引入到与所述可膨胀元件内部空间连通的管中，或者直接引入到所述可膨胀元件中，所述可流动水性溶液包含第一和第二水溶性聚合物前体以及任选的引发剂催化剂，每种水溶性聚合物前体具有末端官能团；
b.将粉末形式的热活化的低温自由基引发剂引入到步骤(a)的可流动水性溶液中；
c.使得所述自由基引发剂在所述可流动水性溶液中溶解，其中，在所述可膨胀元件上游的所述管中布置有滤器，所述滤器具有上游侧和下游侧，所述自由基引发剂布置在所述滤器的上游侧，当所述可流动水性溶液通过所述滤器时，所述自由基引发剂溶解在其中；
d.如果没有在步骤(a)中预先引入的话，则将引发剂催化剂引入步骤(c)的溶液中，和
e.使得所述水溶性聚合物前体上的官能团发生共价键合，以在所述可膨胀元件内的空间中形成固态且基本不可生物降解的材料。
16.如权利要求15所述的方法，其特征在于，所述自由基引发剂布置在所述医疗器械的可膨胀元件中，当所述可流动水性溶液进入所述可膨胀元件时，所述自由基引发剂溶解在所述可流动水性溶液中。
17.如权利要求15所述的方法，其特征在于，所述自由基引发剂布置在与所述可膨胀元件连通的容器内，一部分的所述可流动水性溶液从所述可膨胀元件撤回进入所述容器中，使得所述自由基引发剂溶解在所述可流动水性溶液中，并且将所得到的混合溶液再次引入到所述可膨胀元件中。
18.如权利要求15所述的方法，其特征在于，所述可流动水性溶液是由第一和第二源溶液的混合物形成的，所述第一源溶液包含所述第一水溶性聚合物前体，所述第二源溶液包含所述第二水溶性聚合物前体。
19.如权利要求18所述的方法，其特征在于，在歧管中混合所述第一和第二源溶液，之后与所述自由基引发剂接触。
20.如权利要求18所述的方法，其特征在于，在步骤(a)之前，将包含所述第一和第二水溶性聚合物前体的源溶液和所述引发剂催化剂引入到填充管中。
21.如权利要求18所述的方法，其特征在于，所述第一或第二源溶液包含所述引发剂催化剂。
22.如权利要求15所述的方法，其特征在于，在引入所述引发剂之前引入所述引发剂催化剂，或者在引入所述引发剂之后引入所述引发剂催化剂。
23.如权利要求15所述的方法，其特征在于，所述可流动水性溶液还包含辐射阻挡试剂。
CN201480015060.9A 2013-03-14 2014-03-07 用于在医疗器械内原位形成材料的方法 Expired - Fee Related CN105120910B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361785445P 2013-03-14 2013-03-14
US61/785,445 2013-03-14
PCT/US2014/021928 WO2014159093A1 (en) 2013-03-14 2014-03-07 Method for forming materials in situ within a medical device

Publications (2)

Publication Number Publication Date
CN105120910A CN105120910A (zh) 2015-12-02
CN105120910B true CN105120910B (zh) 2019-04-12

Family

ID=50382728

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480015060.9A Expired - Fee Related CN105120910B (zh) 2013-03-14 2014-03-07 用于在医疗器械内原位形成材料的方法

Country Status (6)

Country Link
US (3) US10201638B2 (zh)
EP (1) EP2968692B8 (zh)
JP (2) JP6533776B2 (zh)
CN (1) CN105120910B (zh)
BR (1) BR112015022688B1 (zh)
WO (1) WO2014159093A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110276078A1 (en) 2009-12-30 2011-11-10 Nellix, Inc. Filling structure for a graft system and methods of use
EP2968692B8 (en) * 2013-03-14 2021-02-24 Endologix LLC Method for forming materials in situ within a medical device
US10598438B2 (en) 2016-07-27 2020-03-24 General Electric Company Support fixture
US20180126590A1 (en) * 2016-11-09 2018-05-10 General Electric Company Method for forming articles through casting or injection molding
WO2018183624A1 (en) 2017-03-29 2018-10-04 The Regents Of The University Of Colorado, A Body Corporate Reverse thermal gels and their use as vascular embolic repair agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101489622A (zh) * 2006-05-30 2009-07-22 因赛普特有限责任公司 医用装置中可原位形成的材料

Family Cites Families (350)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980000007A1 (en) 1978-06-02 1980-01-10 A Rockey Medical sleeve
US4604762A (en) 1981-02-13 1986-08-12 Thoratec Laboratories Corporation Arterial graft prosthesis
US4638803A (en) 1982-09-30 1987-01-27 Rand Robert W Medical apparatus for inducing scar tissue formation in a body
GB8315001D0 (en) 1983-06-01 1983-07-06 Ici Plc Multiple-layer polyolefin films
US5669936A (en) 1983-12-09 1997-09-23 Endovascular Technologies, Inc. Endovascular grafting system and method for use therewith
JPS60227763A (ja) 1984-04-27 1985-11-13 筏　義人 抗血栓性医用材料
US4728328A (en) 1984-10-19 1988-03-01 Research Corporation Cuffed tubular organic prostheses
US4704126A (en) 1985-04-15 1987-11-03 Richards Medical Company Chemical polishing process for titanium and titanium alloy surgical implants
US4936057A (en) 1985-06-21 1990-06-26 Extrude Hone Corporation Method of finish machining the surface of irregularly shaped fluid passages
US4733665C2 (en) 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
US4710192A (en) 1985-12-30 1987-12-01 Liotta Domingo S Diaphragm and method for occlusion of the descending thoracic aorta
US4858264A (en) 1986-09-02 1989-08-22 The United States Of America As Represented By The Secretary Of The Air Force Ultrasonic assisted protective coating removal
US4763654A (en) 1986-09-10 1988-08-16 Jang G David Tandem independently inflatable/deflatable multiple diameter balloon angioplasty catheter systems and method of use
US5002532A (en) 1987-01-06 1991-03-26 Advanced Cardiovascular Systems, Inc. Tandem balloon dilatation catheter
US4800882A (en) 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US5133732A (en) 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
US4892544A (en) 1988-03-07 1990-01-09 Dow Corning Wright Corporation Methods for forming hollow, porous-surfaced elastomeric bodies
CA1322628C (en) 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
US4856516A (en) 1989-01-09 1989-08-15 Cordis Corporation Endovascular stent apparatus and method
US5425739A (en) 1989-03-09 1995-06-20 Avatar Design And Development, Inc. Anastomosis stent and stent selection system
US5074845A (en) 1989-07-18 1991-12-24 Baxter International Inc. Catheter with heat-fused balloon with waist
US5292331A (en) 1989-08-24 1994-03-08 Applied Vascular Engineering, Inc. Endovascular support device
IE73670B1 (en) 1989-10-02 1997-07-02 Medtronic Inc Articulated stent
GB8927282D0 (en) 1989-12-01 1990-01-31 Univ Strathclyde Vascular surgical devices
US5199226A (en) 1990-01-26 1993-04-06 E. B. Thomas Method and apparatus for removing outer coatings from pipe
US5334024A (en) 1990-03-21 1994-08-02 Core-Vent Corporation Transfer abutment
DE4010975A1 (de) 1990-03-28 1991-10-02 Guenter Dr Siebert Andruckvorrichtung
US5221261A (en) 1990-04-12 1993-06-22 Schneider (Usa) Inc. Radially expandable fixation member
US5242399A (en) 1990-04-25 1993-09-07 Advanced Cardiovascular Systems, Inc. Method and system for stent delivery
US5122154A (en) 1990-08-15 1992-06-16 Rhodes Valentine J Endovascular bypass graft
US5139480A (en) 1990-08-22 1992-08-18 Biotech Laboratories, Inc. Necking stents
US4976692A (en) 1990-09-13 1990-12-11 Travenol Laboratories (Israel) Ltd. Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus
US5108417A (en) 1990-09-14 1992-04-28 Interface Biomedical Laboratories Corp. Anti-turbulent, anti-thrombogenic intravascular stent
US5156620A (en) 1991-02-04 1992-10-20 Pigott John P Intraluminal graft/stent and balloon catheter for insertion thereof
JPH066125B2 (ja) 1991-02-05 1994-01-26 寛治 井上 人体に媒体を導入する装置
US5217484A (en) 1991-06-07 1993-06-08 Marks Michael P Retractable-wire catheter device and method
US5766151A (en) 1991-07-16 1998-06-16 Heartport, Inc. Endovascular system for arresting the heart
US5222970A (en) 1991-09-06 1993-06-29 William A. Cook Australia Pty. Ltd. Method of and system for mounting a vascular occlusion balloon on a delivery catheter
CA2079417C (en) 1991-10-28 2003-01-07 Lilip Lau Expandable stents and method of making same
DE69226841T2 (de) 1991-11-05 1999-05-20 Childrens Medical Center Okklusionsvorrichtung zur Reparatur von Herz- und Gefäss-Defekten
FR2683449A1 (fr) 1991-11-08 1993-05-14 Cardon Alain Endoprothese pour implantation transluminale.
US5234437A (en) 1991-12-12 1993-08-10 Target Therapeutics, Inc. Detachable pusher-vasoocclusion coil assembly with threaded coupling
US5261916A (en) 1991-12-12 1993-11-16 Target Therapeutics Detachable pusher-vasoocclusive coil assembly with interlocking ball and keyway coupling
US5316023A (en) 1992-01-08 1994-05-31 Expandable Grafts Partnership Method for bilateral intra-aortic bypass
US5507767A (en) 1992-01-15 1996-04-16 Cook Incorporated Spiral stent
CA2128338C (en) 1992-01-21 2004-10-12 Gladwin S. Das Septal defect closure device
FR2688401B1 (fr) 1992-03-12 1998-02-27 Thierry Richard Endoprothese expansible pour organe tubulaire humain ou animal, et outil de mise en place.
US5282823A (en) 1992-03-19 1994-02-01 Medtronic, Inc. Intravascular radially expandable stent
FR2689388B1 (fr) 1992-04-07 1999-07-16 Celsa Lg Filtre sanguin perfectionne eventuellement resorbable.
US5263964A (en) 1992-05-06 1993-11-23 Coil Partners Ltd. Coaxial traction detachment apparatus and method
DE9390115U1 (de) 1992-05-08 1994-12-22 Schneider Usa Inc Ösophagusstent und Einbringinstrument
US5507771A (en) 1992-06-15 1996-04-16 Cook Incorporated Stent assembly
US5342387A (en) 1992-06-18 1994-08-30 American Biomed, Inc. Artificial support for a blood vessel
USD380831S (en) 1992-08-06 1997-07-08 William Cook Europe A/S Implantable self-expanding stent
US5366473A (en) 1992-08-18 1994-11-22 Ultrasonic Sensing And Monitoring Systems, Inc. Method and apparatus for applying vascular grafts
US5527338A (en) 1992-09-02 1996-06-18 Board Of Regents, The University Of Texas System Intravascular device
US5250071A (en) 1992-09-22 1993-10-05 Target Therapeutics, Inc. Detachable embolic coil assembly using interlocking clasps and method of use
US5350397A (en) 1992-11-13 1994-09-27 Target Therapeutics, Inc. Axially detachable embolic coil assembly
US5530528A (en) 1992-09-28 1996-06-25 Fujitsu Limited Image forming apparatus having contact type, one-component developing unit
US5494029A (en) 1992-09-29 1996-02-27 Hood Laboratories Laryngeal stents
US5383926A (en) 1992-11-23 1995-01-24 Children's Medical Center Corporation Re-expandable endoprosthesis
US5423849A (en) 1993-01-15 1995-06-13 Target Therapeutics, Inc. Vasoocclusion device containing radiopaque fibers
US5630840A (en) 1993-01-19 1997-05-20 Schneider (Usa) Inc Clad composite stent
US5441515A (en) 1993-04-23 1995-08-15 Advanced Cardiovascular Systems, Inc. Ratcheting stent
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
IL105828A (en) 1993-05-28 1999-06-20 Medinol Ltd Medical stent
US5352199A (en) 1993-05-28 1994-10-04 Numed, Inc. Balloon catheter
US5514115A (en) 1993-07-07 1996-05-07 Device For Vascular Intervention, Inc. Flexible housing for intracorporeal use
KR100316863B1 (ko) 1993-07-23 2002-09-26 쿠크 인코포레이티드 판형재료로형성된패턴을가진가요성스텐트
US5735892A (en) 1993-08-18 1998-04-07 W. L. Gore & Associates, Inc. Intraluminal stent graft
US5441510A (en) 1993-09-01 1995-08-15 Technology Development Center Bi-axial cutter apparatus for catheter
WO1995008289A2 (en) 1993-09-16 1995-03-30 Scimed Life Systems, Inc. Percutaneous repair of cardiovascular anomalies and repair compositions
JP3365658B2 (ja) 1993-09-30 2003-01-14 株式会社日本吸収体技術研究所 吸収体製品
US5723004A (en) 1993-10-21 1998-03-03 Corvita Corporation Expandable supportive endoluminal grafts
US5639278A (en) 1993-10-21 1997-06-17 Corvita Corporation Expandable supportive bifurcated endoluminal grafts
WO1995013033A1 (en) 1993-11-08 1995-05-18 Lazarus Harrison M Intraluminal vascular graft and method
JP2703510B2 (ja) 1993-12-28 1998-01-26 アドヴァンスド カーディオヴァスキュラー システムズ インコーポレーテッド 拡大可能なステント及びその製造方法
US5507769A (en) 1994-10-18 1996-04-16 Stentco, Inc. Method and apparatus for forming an endoluminal bifurcated graft
US5443477A (en) 1994-02-10 1995-08-22 Stentco, Inc. Apparatus and method for deployment of radially expandable stents by a mechanical linkage
US5485667A (en) 1994-03-03 1996-01-23 Kleshinski; Stephen J. Method for attaching a marker to a medical instrument
US5549663A (en) 1994-03-09 1996-08-27 Cordis Corporation Endoprosthesis having graft member and exposed welded end junctions, method and procedure
US5417708A (en) 1994-03-09 1995-05-23 Cook Incorporated Intravascular treatment system and percutaneous release mechanism therefor
US5733303A (en) 1994-03-17 1998-03-31 Medinol Ltd. Flexible expandable stent
US5449373A (en) 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
JPH09510637A (ja) 1994-03-18 1997-10-28 クック インコーポレイティッド 螺旋状塞栓形成コイル
EP0679372B1 (en) 1994-04-25 1999-07-28 Advanced Cardiovascular Systems, Inc. Radiopaque stent markers
US5554181A (en) 1994-05-04 1996-09-10 Regents Of The University Of Minnesota Stent
WO1998020939A2 (en) 1996-11-15 1998-05-22 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
US5824044A (en) 1994-05-12 1998-10-20 Endovascular Technologies, Inc. Bifurcated multicapsule intraluminal grafting system
US5765418A (en) 1994-05-16 1998-06-16 Medtronic, Inc. Method for making an implantable medical device from a refractory metal
US5867762A (en) 1994-05-26 1999-02-02 Rafferty; Kevin Masking tape
US5728068A (en) 1994-06-14 1998-03-17 Cordis Corporation Multi-purpose balloon catheter
US5846261A (en) 1994-07-08 1998-12-08 Aga Medical Corp. Percutaneous catheter directed occlusion devices
US6123715A (en) 1994-07-08 2000-09-26 Amplatz; Curtis Method of forming medical devices; intravascular occlusion devices
US5636641A (en) 1994-07-25 1997-06-10 Advanced Cardiovascular Systems, Inc. High strength member for intracorporeal use
US5531741A (en) 1994-08-18 1996-07-02 Barbacci; Josephine A. Illuminated stents
US5609605A (en) 1994-08-25 1997-03-11 Ethicon, Inc. Combination arterial stent
US5578149A (en) 1995-05-31 1996-11-26 Global Therapeutics, Inc. Radially expandable stent
US5591230A (en) 1994-09-07 1997-01-07 Global Therapeutics, Inc. Radially expandable stent
US5545210A (en) 1994-09-22 1996-08-13 Advanced Coronary Technology, Inc. Method of implanting a permanent shape memory alloy stent
US5632760A (en) 1994-10-20 1997-05-27 Cordis Corporation Balloon catheter for stent implantation
US5522882A (en) 1994-10-21 1996-06-04 Impra, Inc. Method and apparatus for balloon expandable stent-graft delivery
NL9500283A (nl) 1994-10-21 1996-06-03 Cordis Europ Catheter met leiddraadkanaal.
US5534024A (en) 1994-11-04 1996-07-09 Aeroquip Corporation Intraluminal stenting graft
JP3182301B2 (ja) 1994-11-07 2001-07-03 キヤノン株式会社 マイクロ構造体及びその形成法
US5549662A (en) 1994-11-07 1996-08-27 Scimed Life Systems, Inc. Expandable stent using sliding members
US5578074A (en) 1994-12-22 1996-11-26 Target Therapeutics, Inc. Implant delivery method and assembly
USD380266S (en) 1994-12-30 1997-06-24 Cook Incorporated Implantable, actively expandable stent
NL9500094A (nl) 1995-01-19 1996-09-02 Industrial Res Bv Y-vormige stent en werkwijze van het plaatsen daarvan.
US5591226A (en) 1995-01-23 1997-01-07 Schneider (Usa) Inc. Percutaneous stent-graft and method for delivery thereof
US5755770A (en) 1995-01-31 1998-05-26 Boston Scientific Corporatiion Endovascular aortic graft
WO1996025897A2 (en) 1995-02-22 1996-08-29 Menlo Care, Inc. Covered expanding mesh stent
US5683449A (en) 1995-02-24 1997-11-04 Marcade; Jean Paul Modular bifurcated intraluminal grafts and methods for delivering and assembling same
US6124523A (en) 1995-03-10 2000-09-26 Impra, Inc. Encapsulated stent
US6451047B2 (en) 1995-03-10 2002-09-17 Impra, Inc. Encapsulated intraluminal stent-graft and methods of making same
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US5605530A (en) 1995-03-23 1997-02-25 Fischell; Robert E. System for safe implantation of radioisotope stents
BE1009278A3 (fr) 1995-04-12 1997-01-07 Corvita Europ Tuteur auto-expansible pour dispositif medical a introduire dans une cavite d'un corps, et dispositif medical muni d'un tel tuteur.
BE1009277A3 (fr) 1995-04-12 1997-01-07 Corvita Europ Tuteur auto-expansible pour dispositif medical a introduire dans une cavite d'un corps, et son procede de preparation.
US5662614A (en) 1995-05-09 1997-09-02 Edoga; John K. Balloon expandable universal access sheath
US5591228A (en) 1995-05-09 1997-01-07 Edoga; John K. Methods for treating abdominal aortic aneurysms
CA2178541C (en) 1995-06-07 2009-11-24 Neal E. Fearnot Implantable medical device
US6033434A (en) 1995-06-08 2000-03-07 Ave Galway Limited Bifurcated endovascular stent and methods for forming and placing
US5728131A (en) 1995-06-12 1998-03-17 Endotex Interventional Systems, Inc. Coupling device and method of use
US5725568A (en) 1995-06-27 1998-03-10 Scimed Life Systems, Inc. Method and device for recanalizing and grafting arteries
US5782907A (en) 1995-07-13 1998-07-21 Devices For Vascular Intervention, Inc. Involuted spring stent and graft assembly and method of use
US5785679A (en) 1995-07-19 1998-07-28 Endotex Interventional Systems, Inc. Methods and apparatus for treating aneurysms and arterio-venous fistulas
US5769882A (en) 1995-09-08 1998-06-23 Medtronic, Inc. Methods and apparatus for conformably sealing prostheses within body lumens
US5601600A (en) 1995-09-08 1997-02-11 Conceptus, Inc. Endoluminal coil delivery system having a mechanical release mechanism
US5824036A (en) 1995-09-29 1998-10-20 Datascope Corp Stent for intraluminal grafts and device and methods for delivering and assembling same
US6193745B1 (en) 1995-10-03 2001-02-27 Medtronic, Inc. Modular intraluminal prosteheses construction and methods
US5824037A (en) 1995-10-03 1998-10-20 Medtronic, Inc. Modular intraluminal prostheses construction and methods
US5776161A (en) 1995-10-16 1998-07-07 Instent, Inc. Medical stents, apparatus and method for making same
DE69612507T2 (de) 1995-10-30 2001-08-09 Childrens Medical Center Selbstzentrierende, schirmartige vorrichtung zum verschliessen eines septal-defektes
US6287315B1 (en) 1995-10-30 2001-09-11 World Medical Manufacturing Corporation Apparatus for delivering an endoluminal prosthesis
US5591195A (en) 1995-10-30 1997-01-07 Taheri; Syde Apparatus and method for engrafting a blood vessel
US5632762A (en) 1995-11-09 1997-05-27 Hemodynamics, Inc. Ostial stent balloon
US5607442A (en) 1995-11-13 1997-03-04 Isostent, Inc. Stent with improved radiopacity and appearance characteristics
US5868685A (en) 1995-11-14 1999-02-09 Devices For Vascular Intervention Articulated guidewire
IT1276141B1 (it) 1995-11-16 1997-10-27 Soten Srl Film termoretraibile poliolefinico a piu' strati coestrusi avente una migliorata resistenza della saldatura
US5788626A (en) 1995-11-21 1998-08-04 Schneider (Usa) Inc Method of making a stent-graft covered with expanded polytetrafluoroethylene
US5593417A (en) 1995-11-27 1997-01-14 Rhodes; Valentine J. Intravascular stent with secure mounting means
US5665117A (en) 1995-11-27 1997-09-09 Rhodes; Valentine J. Endovascular prosthesis with improved sealing means for aneurysmal arterial disease and method of use
US5824040A (en) 1995-12-01 1998-10-20 Medtronic, Inc. Endoluminal prostheses and therapies for highly variable body lumens
US6576009B2 (en) 1995-12-01 2003-06-10 Medtronic Ave, Inc. Bifurcated intraluminal prostheses construction and methods
US6878161B2 (en) 1996-01-05 2005-04-12 Medtronic Vascular, Inc. Stent graft loading and deployment device and method
ATE290832T1 (de) 1996-01-05 2005-04-15 Medtronic Inc Expandierbare endoluminale prothesen
US5800512A (en) 1996-01-22 1998-09-01 Meadox Medicals, Inc. PTFE vascular graft
US6168622B1 (en) 1996-01-24 2001-01-02 Microvena Corporation Method and apparatus for occluding aneurysms
US5871537A (en) 1996-02-13 1999-02-16 Scimed Life Systems, Inc. Endovascular apparatus
US5690643A (en) 1996-02-20 1997-11-25 Leocor, Incorporated Stent delivery system
US5925054A (en) 1996-02-20 1999-07-20 Cardiothoracic Systems, Inc. Perfusion device for maintaining blood flow in a vessel while isolating an anastomosis
US5879381A (en) 1996-03-10 1999-03-09 Terumo Kabushiki Kaisha Expandable stent for implanting in a body
US5843160A (en) 1996-04-01 1998-12-01 Rhodes; Valentine J. Prostheses for aneurysmal and/or occlusive disease at a bifurcation in a vessel, duct, or lumen
US6458096B1 (en) 1996-04-01 2002-10-01 Medtronic, Inc. Catheter with autoinflating, autoregulating balloon
BE1010183A3 (fr) 1996-04-25 1998-02-03 Dereume Jean Pierre Georges Em Endoprothese luminale pour ramification de voies d'un corps humain ou animal et son procede de fabrication.
US6544276B1 (en) 1996-05-20 2003-04-08 Medtronic Ave. Inc. Exchange method for emboli containment
US5800514A (en) 1996-05-24 1998-09-01 Meadox Medicals, Inc. Shaped woven tubular soft-tissue prostheses and methods of manufacturing
US5617878A (en) 1996-05-31 1997-04-08 Taheri; Syde A. Stent and method for treatment of aortic occlusive disease
US5755773A (en) 1996-06-04 1998-05-26 Medtronic, Inc. Endoluminal prosthetic bifurcation shunt
US5697971A (en) 1996-06-11 1997-12-16 Fischell; Robert E. Multi-cell stent with cells having differing characteristics
US6190402B1 (en) 1996-06-21 2001-02-20 Musc Foundation For Research Development Insitu formable and self-forming intravascular flow modifier (IFM) and IFM assembly for deployment of same
US5928279A (en) 1996-07-03 1999-07-27 Baxter International Inc. Stented, radially expandable, tubular PTFE grafts
US5980514A (en) 1996-07-26 1999-11-09 Target Therapeutics, Inc. Aneurysm closure device assembly
US5676697A (en) 1996-07-29 1997-10-14 Cardiovascular Dynamics, Inc. Two-piece, bifurcated intraluminal graft for repair of aneurysm
US6325819B1 (en) 1996-08-19 2001-12-04 Cook Incorporated Endovascular prosthetic device, an endovascular graft prothesis with such a device, and a method for repairing an abdominal aortic aneurysm
US6306165B1 (en) 1996-09-13 2001-10-23 Meadox Medicals ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin
US6007573A (en) 1996-09-18 1999-12-28 Microtherapeutics, Inc. Intracranial stent and method of use
US5807404A (en) 1996-09-19 1998-09-15 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
DE69734667T2 (de) 1996-09-26 2006-06-08 Boston Scientific Scimed, Inc., Maple Grove Kombinierte medizinische vorrichtung bestehend aus einer stützstruktur und einem membran
US5755778A (en) 1996-10-16 1998-05-26 Nitinol Medical Technologies, Inc. Anastomosis device
US5976178A (en) 1996-11-07 1999-11-02 Vascular Science Inc. Medical grafting methods
US5860998A (en) 1996-11-25 1999-01-19 C. R. Bard, Inc. Deployment device for tubular expandable prosthesis
US6015431A (en) 1996-12-23 2000-01-18 Prograft Medical, Inc. Endolumenal stent-graft with leak-resistant seal
US5868782A (en) 1996-12-24 1999-02-09 Global Therapeutics, Inc. Radially expandable axially non-contracting surgical stent
EP0850607A1 (en) 1996-12-31 1998-07-01 Cordis Corporation Valve prosthesis for implantation in body channels
US5947991A (en) 1997-01-07 1999-09-07 Cowan; Robert K. Single balloon device for cervix
US5827321A (en) 1997-02-07 1998-10-27 Cornerstone Devices, Inc. Non-Foreshortening intraluminal prosthesis
US6254633B1 (en) 1997-02-12 2001-07-03 Corvita Corporation Delivery device for a medical device having a constricted region
US5919224A (en) 1997-02-12 1999-07-06 Schneider (Usa) Inc Medical device having a constricted region for occluding fluid flow in a body lumen
US5800393A (en) 1997-03-07 1998-09-01 Sahota; Harvinder Wire perfusion catheter
US5810872A (en) 1997-03-14 1998-09-22 Kanesaka; Nozomu Flexible stent
US5824054A (en) 1997-03-18 1998-10-20 Endotex Interventional Systems, Inc. Coiled sheet graft stent and methods of making and use
US5718713A (en) 1997-04-10 1998-02-17 Global Therapeutics, Inc. Surgical stent having a streamlined contour
US5741327A (en) 1997-05-06 1998-04-21 Global Therapeutics, Inc. Surgical stent featuring radiopaque markers
US5868708A (en) 1997-05-07 1999-02-09 Applied Medical Resources Corporation Balloon catheter apparatus and method
US5836966A (en) 1997-05-22 1998-11-17 Scimed Life Systems, Inc. Variable expansion force stent
AUPO700897A0 (en) 1997-05-26 1997-06-19 William A Cook Australia Pty Ltd A method and means of deploying a graft
US5800525A (en) 1997-06-04 1998-09-01 Vascular Science, Inc. Blood filter
US5746691A (en) 1997-06-06 1998-05-05 Global Therapeutics, Inc. Method for polishing surgical stents
US5843175A (en) 1997-06-13 1998-12-01 Global Therapeutics, Inc. Enhanced flexibility surgical stent
GB9713624D0 (en) 1997-06-28 1997-09-03 Anson Medical Ltd Expandable device
US5944750A (en) 1997-06-30 1999-08-31 Eva Corporation Method and apparatus for the surgical repair of aneurysms
US5863627A (en) 1997-08-26 1999-01-26 Cardiotech International, Inc. Hydrolytically-and proteolytically-stable polycarbonate polyurethane silicone copolymers
US6187033B1 (en) 1997-09-04 2001-02-13 Meadox Medicals, Inc. Aortic arch prosthetic graft
US6306164B1 (en) 1997-09-05 2001-10-23 C. R. Bard, Inc. Short body endoprosthesis
US5984955A (en) 1997-09-11 1999-11-16 Wisselink; Willem System and method for endoluminal grafting of bifurcated or branched vessels
US6042606A (en) 1997-09-29 2000-03-28 Cook Incorporated Radially expandable non-axially contracting surgical stent
US6132457A (en) 1997-10-22 2000-10-17 Triad Vascular Systems, Inc. Endovascular graft having longitudinally displaceable sections
WO1999026559A1 (en) 1997-11-25 1999-06-03 Triad Vascular Systems, Inc. Layered endovascular graft
US6190406B1 (en) 1998-01-09 2001-02-20 Nitinal Development Corporation Intravascular stent having tapered struts
US5873907A (en) 1998-01-27 1999-02-23 Endotex Interventional Systems, Inc. Electrolytic stent delivery system and methods of use
US6395019B2 (en) 1998-02-09 2002-05-28 Trivascular, Inc. Endovascular graft
CA2320868C (en) 1998-02-12 2008-08-12 Thomas R. Marotta Endovascular prosthesis
US5931866A (en) 1998-02-24 1999-08-03 Frantzen; John J. Radially expandable stent featuring accordion stops
US5938697A (en) 1998-03-04 1999-08-17 Scimed Life Systems, Inc. Stent having variable properties
US6099497A (en) 1998-03-05 2000-08-08 Scimed Life Systems, Inc. Dilatation and stent delivery system for bifurcation lesions
US6129756A (en) 1998-03-16 2000-10-10 Teramed, Inc. Biluminal endovascular graft system
US6290731B1 (en) 1998-03-30 2001-09-18 Cordis Corporation Aortic graft having a precursor gasket for repairing an abdominal aortic aneurysm
US6887268B2 (en) 1998-03-30 2005-05-03 Cordis Corporation Extension prosthesis for an arterial repair
US6463317B1 (en) 1998-05-19 2002-10-08 Regents Of The University Of Minnesota Device and method for the endovascular treatment of aneurysms
US6293960B1 (en) 1998-05-22 2001-09-25 Micrus Corporation Catheter with shape memory polymer distal tip for deployment of therapeutic devices
US6296603B1 (en) 1998-05-26 2001-10-02 Isostent, Inc. Radioactive intraluminal endovascular prosthesis and method for the treatment of aneurysms
US6203732B1 (en) 1998-07-02 2001-03-20 Intra Therapeutics, Inc. Method for manufacturing intraluminal device
US6099548A (en) 1998-07-28 2000-08-08 Taheri; Syde A. Apparatus and method for deploying an aortic arch graft
US6093199A (en) 1998-08-05 2000-07-25 Endovascular Technologies, Inc. Intra-luminal device for treatment of body cavities and lumens and method of use
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
KR20010072816A (ko) 1998-08-20 2001-07-31 쿡 인코포레이티드 피복된 삽입용 의료 장치
US6196230B1 (en) 1998-09-10 2001-03-06 Percardia, Inc. Stent delivery system and method of use
US6368345B1 (en) 1998-09-30 2002-04-09 Edwards Lifesciences Corporation Methods and apparatus for intraluminal placement of a bifurcated intraluminal garafat
US6547814B2 (en) 1998-09-30 2003-04-15 Impra, Inc. Selective adherence of stent-graft coverings
US6293967B1 (en) 1998-10-29 2001-09-25 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6152144A (en) 1998-11-06 2000-11-28 Appriva Medical, Inc. Method and device for left atrial appendage occlusion
US6083259A (en) 1998-11-16 2000-07-04 Frantzen; John J. Axially non-contracting flexible radially expandable stent
WO2000029060A2 (en) 1998-11-19 2000-05-25 Percusurge, Inc. Low volume syringe and method for inflating surgical balloons
US6022359A (en) 1999-01-13 2000-02-08 Frantzen; John J. Stent delivery system featuring a flexible balloon
US6187034B1 (en) 1999-01-13 2001-02-13 John J. Frantzen Segmented stent for flexible stent delivery system
US7524289B2 (en) 1999-01-25 2009-04-28 Lenker Jay A Resolution optical and ultrasound devices for imaging and treatment of body lumens
US6896690B1 (en) * 2000-01-27 2005-05-24 Viacor, Inc. Cardiac valve procedure methods and devices
GB9904722D0 (en) * 1999-03-03 1999-04-21 Murch Clifford R A tubular intraluminal graft
US6663607B2 (en) 1999-07-12 2003-12-16 Scimed Life Systems, Inc. Bioactive aneurysm closure device assembly and kit
IT1307263B1 (it) 1999-08-05 2001-10-30 Sorin Biomedica Cardio Spa Stent per angioplastica con azione antagonista della restenosi,relativo corredo e componenti.
US7022100B1 (en) 1999-09-03 2006-04-04 A-Med Systems, Inc. Guidable intravascular blood pump and related methods
US6409757B1 (en) 1999-09-15 2002-06-25 Eva Corporation Method and apparatus for supporting a graft assembly
US6312462B1 (en) * 1999-09-22 2001-11-06 Impra, Inc. Prosthesis for abdominal aortic aneurysm repair
AUPQ302899A0 (en) 1999-09-23 1999-10-21 Endogad Research Pty Limited Implants for the use in the treatment of aneurysmal disease
US6344056B1 (en) 1999-12-29 2002-02-05 Edwards Lifesciences Corp. Vascular grafts for bridging a vessel side branch
US6280466B1 (en) 1999-12-03 2001-08-28 Teramed Inc. Endovascular graft system
US6331184B1 (en) 1999-12-10 2001-12-18 Scimed Life Systems, Inc. Detachable covering for an implantable medical device
US6663667B2 (en) 1999-12-29 2003-12-16 Edwards Lifesciences Corporation Towel graft means for enhancing tissue ingrowth in vascular grafts
US6241761B1 (en) 2000-01-26 2001-06-05 Cabg Medical, Inc. Stented grafts for coupling vascular members
US6312463B1 (en) 2000-02-01 2001-11-06 Endotex Interventional Systems, Inc. Micro-porous mesh stent with hybrid structure
US6432129B2 (en) 2000-02-22 2002-08-13 Scimed Life Systems, Inc. Stent delivery system
AU2001241909A1 (en) 2000-03-03 2001-09-17 Timothy A.M. Chuter Large vessel stents and occluders
AU769900B2 (en) 2000-03-03 2004-02-05 Cook Medical Technologies Llc Endovascular device having a stent
US6290722B1 (en) 2000-03-13 2001-09-18 Endovascular Technologies, Inc. Tacky attachment method of covered materials on stents
US20020026217A1 (en) 2000-04-26 2002-02-28 Steven Baker Apparatus and method for repair of perigraft flow
US6729356B1 (en) 2000-04-27 2004-05-04 Endovascular Technologies, Inc. Endovascular graft for providing a seal with vasculature
US6692486B2 (en) 2000-05-10 2004-02-17 Minnesota Medical Physics, Llc Apparatus and method for treatment of cerebral aneurysms, arterial-vascular malformations and arterial fistulas
US6964667B2 (en) 2000-06-23 2005-11-15 Sdgi Holdings, Inc. Formed in place fixation system with thermal acceleration
US20050107738A1 (en) * 2000-07-21 2005-05-19 Slater Charles R. Occludable intravascular catheter for drug delivery and method of using the same
US6773454B2 (en) 2000-08-02 2004-08-10 Michael H. Wholey Tapered endovascular stent graft and method of treating abdominal aortic aneurysms and distal iliac aneurysms
EP1309289A2 (en) * 2000-08-18 2003-05-14 Atritech, Inc. Expandable implant devices for filtering blood flow from atrial appendages
WO2002022198A2 (en) 2000-09-14 2002-03-21 Tuborg Engineering Nv Adaptive balloon with improved flexibility
US6945989B1 (en) 2000-09-18 2005-09-20 Endotex Interventional Systems, Inc. Apparatus for delivering endoluminal prostheses and methods of making and using them
US6695833B1 (en) 2000-09-27 2004-02-24 Nellix, Inc. Vascular stent-graft apparatus and forming method
US6730119B1 (en) 2000-10-06 2004-05-04 Board Of Regents Of The University Of Texas System Percutaneous implantation of partially covered stents in aneurysmally dilated arterial segments with subsequent embolization and obliteration of the aneurysm cavity
US7229472B2 (en) 2000-11-16 2007-06-12 Cordis Corporation Thoracic aneurysm repair prosthesis and system
US7314483B2 (en) 2000-11-16 2008-01-01 Cordis Corp. Stent graft with branch leg
US6579301B1 (en) 2000-11-17 2003-06-17 Syntheon, Llc Intragastric balloon device adapted to be repeatedly varied in volume without external assistance
US6645242B1 (en) 2000-12-11 2003-11-11 Stephen F. Quinn Bifurcated side-access intravascular stent graft
US6623452B2 (en) 2000-12-19 2003-09-23 Scimed Life Systems, Inc. Drug delivery catheter having a highly compliant balloon with infusion holes
US6547804B2 (en) 2000-12-27 2003-04-15 Scimed Life Systems, Inc. Selectively permeable highly distensible occlusion balloon
US20020169497A1 (en) 2001-01-02 2002-11-14 Petra Wholey Endovascular stent system and method of providing aneurysm embolization
WO2002076346A1 (en) 2001-03-23 2002-10-03 Hassan Tehrani Branched aortic arch stent graft
AU2002248765B2 (en) 2001-03-28 2006-11-30 Cook Medical Technologies Llc Modular stent graft assembly and use thereof
US6761733B2 (en) 2001-04-11 2004-07-13 Trivascular, Inc. Delivery system and method for bifurcated endovascular graft
US6733521B2 (en) 2001-04-11 2004-05-11 Trivascular, Inc. Delivery system and method for endovascular graft
US7175651B2 (en) 2001-07-06 2007-02-13 Andrew Kerr Stent/graft assembly
US6969373B2 (en) 2001-04-13 2005-11-29 Tricardia, Llc Syringe system
US6796960B2 (en) 2001-05-04 2004-09-28 Wit Ip Corporation Low thermal resistance elastic sleeves for medical device balloons
US6890303B2 (en) 2001-05-31 2005-05-10 Matthew Joseph Fitz Implantable device for monitoring aneurysm sac parameters
JP2005505319A (ja) 2001-06-19 2005-02-24 イーバ コーポレイション 位置決めアセンブリ及び使用方法
GB0114918D0 (en) 2001-06-19 2001-08-08 Vortex Innovation Ltd Devices for repairing aneurysms
US20030014075A1 (en) 2001-07-16 2003-01-16 Microvention, Inc. Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation
WO2003009764A1 (en) 2001-07-26 2003-02-06 Oregon Health Sciences University Vessel closure member and delivery apparatus
US20030028209A1 (en) 2001-07-31 2003-02-06 Clifford Teoh Expandable body cavity liner device
US7192441B2 (en) 2001-10-16 2007-03-20 Scimed Life Systems, Inc. Aortic artery aneurysm endovascular prosthesis
DE60229416D1 (de) 2001-10-25 2008-11-27 Univ Emory Katheter für modifizierte Perfusion
AUPR847201A0 (en) 2001-10-26 2001-11-15 Cook Incorporated Endoluminal graft
US6958051B2 (en) 2001-10-29 2005-10-25 Scimed Life Systems, Inc. Dual balloon valve control with pressure indicator
WO2003043552A1 (en) * 2001-11-16 2003-05-30 Biocure, Inc. Methods for initiating in situ formation of hydrogels
US20060292206A1 (en) 2001-11-26 2006-12-28 Kim Steven W Devices and methods for treatment of vascular aneurysms
US7823267B2 (en) 2001-11-28 2010-11-02 Aptus Endosystems, Inc. Devices, systems, and methods for prosthesis delivery and implantation, including the use of a fastener tool
US6746465B2 (en) 2001-12-14 2004-06-08 The Regents Of The University Of California Catheter based balloon for therapy modification and positioning of tissue
WO2003053288A1 (en) 2001-12-20 2003-07-03 Trivascular, Inc. Advanced endovascular graft
US7147661B2 (en) 2001-12-20 2006-12-12 Boston Scientific Santa Rosa Corp. Radially expandable stent
FR2834199B1 (fr) 2001-12-27 2004-10-15 Doron Carmi Endoprothese adaptee au milieu endoluminal
US20030130725A1 (en) 2002-01-08 2003-07-10 Depalma Donald F. Sealing prosthesis
US20030130720A1 (en) 2002-01-08 2003-07-10 Depalma Donald F. Modular aneurysm repair system
US7326237B2 (en) 2002-01-08 2008-02-05 Cordis Corporation Supra-renal anchoring prosthesis
US6679300B1 (en) 2002-01-14 2004-01-20 Thermogenesis Corp. Biological adhesive loading station and method
US20030135269A1 (en) 2002-01-16 2003-07-17 Swanstrom Lee L. Laparoscopic-assisted endovascular/endoluminal graft placement
US7131991B2 (en) 2002-04-24 2006-11-07 Medtronic Vascular, Inc. Endoluminal prosthetic assembly and extension method
US6918926B2 (en) 2002-04-25 2005-07-19 Medtronic Vascular, Inc. System for transrenal/intraostial fixation of endovascular prosthesis
US20030204249A1 (en) 2002-04-25 2003-10-30 Michel Letort Endovascular stent graft and fixation cuff
US6780170B2 (en) 2002-05-15 2004-08-24 Liebel-Flarsheim Company Hydraulic remote for a medical fluid injector
WO2003101346A1 (en) 2002-05-29 2003-12-11 William A. Cook Australia Pty. Ltd. Multi-piece prosthesis deployment apparatus
US6656220B1 (en) 2002-06-17 2003-12-02 Advanced Cardiovascular Systems, Inc. Intravascular stent
US6833003B2 (en) 2002-06-24 2004-12-21 Cordis Neurovascular Expandable stent and delivery system
US7314484B2 (en) 2002-07-02 2008-01-01 The Foundry, Inc. Methods and devices for treating aneurysms
US20050096731A1 (en) 2002-07-11 2005-05-05 Kareen Looi Cell seeded expandable body
JP2004063081A (ja) 2002-07-24 2004-02-26 Renesas Technology Corp 半導体パッケージ用ソケット
WO2004017866A1 (en) 2002-08-20 2004-03-04 Cook Incorporated Stent graft with improved proximal end
WO2004026183A2 (en) 2002-09-20 2004-04-01 Nellix, Inc. Stent-graft with positioning anchor
US20060265043A1 (en) 2002-09-30 2006-11-23 Evgenia Mandrusov Method and apparatus for treating vulnerable plaque
US20040098096A1 (en) 2002-10-22 2004-05-20 The University Of Miami Endograft device to inhibit endoleak and migration
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
AU2003299946A1 (en) 2002-12-30 2004-07-29 Morsi Hesham Endovascular balloon graft
US20040153025A1 (en) 2003-02-03 2004-08-05 Seifert Paul S. Systems and methods of de-endothelialization
DE10305553B4 (de) 2003-02-10 2005-11-03 Lothar Dr.med. Göbel Vorrichtung zur Tamponade von Körperhöhlen
EP1613242B1 (en) 2003-03-26 2013-02-20 The Foundry, LLC Devices for treatment of abdominal aortic aneurysms
US7396540B2 (en) 2003-04-25 2008-07-08 Medtronic Vascular, Inc. In situ blood vessel and aneurysm treatment
US7625401B2 (en) 2003-05-06 2009-12-01 Abbott Laboratories Endoprosthesis having foot extensions
US20050028484A1 (en) 2003-06-20 2005-02-10 Littlewood Richard W. Method and apparatus for sleeving compressed bale materials
US20050065592A1 (en) 2003-09-23 2005-03-24 Asher Holzer System and method of aneurism monitoring and treatment
US7122052B2 (en) 2003-09-29 2006-10-17 Stout Medical Group Lp Integral support stent graft assembly
US20050090804A1 (en) 2003-10-22 2005-04-28 Trivascular, Inc. Endoluminal prosthesis endoleak management
US7727228B2 (en) 2004-03-23 2010-06-01 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
WO2005099807A2 (en) 2004-04-13 2005-10-27 Endologix, Inc. Method and apparatus for decompressing aneurysms
ATE540640T1 (de) 2004-07-22 2012-01-15 Nellix Inc Systeme zur behandlung von endovaskulären aneurysmen
US8048145B2 (en) 2004-07-22 2011-11-01 Endologix, Inc. Graft systems having filling structures supported by scaffolds and methods for their use
CA2581857C (en) 2004-09-28 2013-07-16 William A. Cook Australia Pty. Ltd. Device for treating aortic dissection
US20060074481A1 (en) 2004-10-04 2006-04-06 Gil Vardi Graft including expandable cuff
US20060095121A1 (en) 2004-10-28 2006-05-04 Medtronic Vascular, Inc. Autologous platelet gel on a stent graft
CA2586018A1 (en) 2004-11-03 2006-07-13 Jacques Seguin Vascular graft and deployment system
US20070032850A1 (en) 2004-12-16 2007-02-08 Carlos Ruiz Separable sheath and method for insertion of a medical device into a bodily vessel using a separable sheath
JP2008532573A (ja) 2005-01-21 2008-08-21 ジェン ４，リミティド ライアビリティー カンパニー 二股グラフト及び脚部取付けステント要素を採用したモジュール式ステントグラフト
US20060222596A1 (en) 2005-04-01 2006-10-05 Trivascular, Inc. Non-degradable, low swelling, water soluble radiopaque hydrogel polymer
CN102309370B (zh) 2005-04-04 2015-04-15 灵活支架解决方案股份有限公司 可挠支架
WO2006116725A2 (en) 2005-04-28 2006-11-02 Nellix, Inc. Graft systems having filling structures supported by scaffolds and methods for their use
AU2006269419A1 (en) 2005-07-07 2007-01-18 Nellix, Inc. Systems and methods for endovascular aneurysm treatment
DE102005037982B3 (de) 2005-08-02 2007-03-15 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Verfahren zur Herstellung metallhaltiger Gusskörper und Vorrichtung dafür
US20070043420A1 (en) 2005-08-17 2007-02-22 Medtronic Vascular, Inc. Apparatus and method for stent-graft release using a cap
US20070150041A1 (en) 2005-12-22 2007-06-28 Nellix, Inc. Methods and systems for aneurysm treatment using filling structures
US20070162109A1 (en) 2006-01-11 2007-07-12 Luis Davila Intraluminal stent graft
US7790273B2 (en) 2006-05-24 2010-09-07 Nellix, Inc. Material for creating multi-layered films and methods for making the same
US7771476B2 (en) 2006-12-21 2010-08-10 Warsaw Orthopedic Inc. Curable orthopedic implant devices configured to harden after placement in vivo by application of a cure-initiating energy before insertion
US20080228259A1 (en) 2007-03-16 2008-09-18 Jack Fa-De Chu Endovascular devices and methods to protect aneurysmal wall
US20080294237A1 (en) 2007-04-04 2008-11-27 Jack Fa-De Chu Inflatable devices and methods to protect aneurysmal wall
AU2008308474B2 (en) 2007-10-04 2014-07-24 Trivascular, Inc. Modular vascular graft for low profile percutaneous delivery
CA2714570A1 (en) 2008-02-13 2009-08-20 Nellix, Inc. Graft endoframe having axially variable characteristics
US9259225B2 (en) 2008-02-19 2016-02-16 St. Jude Medical, Cardiology Division, Inc. Medical devices for treating a target site and associated method
CA2721950A1 (en) 2008-04-25 2009-10-29 Nellix, Inc. Stent graft delivery system
CA2726596A1 (en) 2008-06-04 2009-12-10 Nellix, Inc. Sealing apparatus and methods of use
US20090319029A1 (en) 2008-06-04 2009-12-24 Nellix, Inc. Docking apparatus and methods of use
CN105147226A (zh) * 2010-03-09 2015-12-16 智能医疗***有限公司 球囊内窥镜及其制造和使用方法
US9314587B2 (en) * 2012-04-18 2016-04-19 Edwards Lifesciences Corporation Retrograde cardioplegia delivery catheter and method for inducing cardioplegic arrest
EP2968692B8 (en) * 2013-03-14 2021-02-24 Endologix LLC Method for forming materials in situ within a medical device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101489622A (zh) * 2006-05-30 2009-07-22 因赛普特有限责任公司 医用装置中可原位形成的材料

Also Published As

Publication number Publication date
BR112015022688A2 (pt) 2017-07-18
EP2968692A1 (en) 2016-01-20
JP2016511087A (ja) 2016-04-14
US20160030051A1 (en) 2016-02-04
JP6951379B2 (ja) 2021-10-20
US11497836B2 (en) 2022-11-15
WO2014159093A1 (en) 2014-10-02
CN105120910A (zh) 2015-12-02
JP6533776B2 (ja) 2019-06-19
JP2019136561A (ja) 2019-08-22
US20140277385A1 (en) 2014-09-18
EP2968692B1 (en) 2020-11-18
US20190167856A1 (en) 2019-06-06
US10201638B2 (en) 2019-02-12
BR112015022688A8 (pt) 2019-11-26
EP2968692B8 (en) 2021-02-24
US9289536B2 (en) 2016-03-22
BR112015022688B1 (pt) 2020-10-06

Similar Documents

Publication Publication Date Title
CN105120910B (zh) 用于在医疗器械内原位形成材料的方法
CN101056595B (zh) 用于治疗血管中的缺陷的组合物、***和方法
US7776063B2 (en) In situ materials formation
US7033571B2 (en) Multiple stimulus reversible hydrogels
ES2700161T3 (es) Métodos para obtener hidrogeles liofilizados superabsorbentes para aplicaciones médicas
US11759553B2 (en) Method for forming hydrogels and materials therefor
Nguyen et al. pH-Sensitive sulfamethazine-based hydrogels as potential embolic agents for transcatheter vascular embolization
CN114230678B (zh) 一种用于血管内治疗的光交联水凝胶栓塞***及使用方法
WO2017086793A1 (en) Composition for use in the treatment or prevention of endoleak
US20130312764A1 (en) Composition For Use In Occluding A Body Duct In A Living Creature
US20210022743A1 (en) In vivo crosslinking of embolic hydrogels using bioorthogonal click chemistry
CN105561405A (zh) 一种用于输卵管栓塞的医用材料及其制备方法
JP2022553929A (ja) 薬剤溶出形状記憶発泡体
WO2023010115A1 (en) Biomaterials for embolization and drug delivery

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CP01 Change in the name or title of a patent holder

Address after: California, USA

Patentee after: Endorojex LLC

Address before: California, USA

Patentee before: ENDOLOGIX, Inc.

CP01 Change in the name or title of a patent holder
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20190412

CF01 Termination of patent right due to non-payment of annual fee