CN105120666A

CN105120666A - Seed treatment formulations

Info

Publication number: CN105120666A
Application number: CN201480017231.1A
Authority: CN
Inventors: 凯伦·S·亚瑟; 弗兰克·冈萨雷斯; 迈克尔·塞茨; 小川俊哉
Original assignee: Sumitomo Chemical Co Ltd; Valent USA LLC
Current assignee: Sumitomo Chemical Co Ltd
Priority date: 2013-02-22
Filing date: 2014-02-20
Publication date: 2015-12-02
Also published as: JP2016513123A; CA2901953C; CA2901953A1; JP6370318B2; MX2015010930A; BR112015020089A2; WO2014130653A8; AR094874A1; EP2961274A1; MX371531B; WO2014130653A1; EP2961274A4

Abstract

The present invention generally relates to aqueous seed treatment formulations comprising from about 0.2 to about 15 % of at least one pesticidal agent, from about 0.1 to about 0.45 % of at least one graft copolymer, at least one polyvinyl alcohol (PVA), and from about 5 to about 30 % of at least one plasticizer. The present invention also relates to aqueous seed treatment formulations wherein the pesticidal agents are clothianidin, metconazole, and metalaxyl.

Description

Seed treatment formulations

related application

This application claims the U.S. Patent Application Serial Number 13/774 submitted on February 22nd, 2013, the rights and interests of 372, this application requires the U.S. Patent Application Serial Number 13/328 submitted on December 16th, 2011, the rights and interests of 643, this application requires the U.S. Patent Application Serial Number 12/326 submitted on December 2nd, 2008, 309 and disclosed in 31 days July in 2012 U.S. Patent number 8, 232, the rights and interests of 229, this application requires the U.S. Provisional Application number 60/991 submitted on December 3rd, 2007, 969, the U.S. Provisional Application number 60/991 submitted on December 3rd, 2007, the U.S.Provisional Serial 60/991 that on December 3rd, 976 and 2007 submits to, the rights and interests of 985.The instruction of above-mentioned cited application is incorporated to herein by reference.

Technical field

The present invention relates generally to protective plant propagating materials not by the water-based seed treatment formulations of pest attack.

Background technology

The practice using pesticidal preparations process seed or other plant propagation material is known.Insecticide and fungicide are applied to seed with the whole development of plants protecting them in soil in early days from insect.Usual use two kinds of pesticidal preparations: wetting powder and aqueous suspension agent.

The seed treatment formulations of business needs special equipment suitably to apply the seed of they or process large volume.Described seed-treating apparatus (subprocessors) in conjunction with commercially available preparation to prepare agricultural-chemical suspension liquid.The example of subprocessors comprises Gustafson rH-24, hC3000 etc.The pesticidal preparations of business is formulated into suspending concentrate usually.Subprocessors is also for being added into sticker, binding agent, polymer and/or colouring agent in agricultural-chemical suspension liquid with lifting operation and safety.Described additive reduction is dusted, and described colouring agent makes agriculturist watch out for this chemical treatment.

Can be used on the quantity of per unit seed additive in seed application and the amount of agricultural chemicals is limited to the dressing and dry technology that can be used for business seed-treating apparatus.The fluid of each crops only adsorbable limited amount, exceeding this amount seed can not carry out suitable drying and/or process in seed processing equipment or plantation equipment.

In addition, many existing preparations comprise low-molecular-weight (LMW) surfactant of high concentration.These LMW surfactants of usual interpolation are with the dispersion of stable agricultural chemicals and provide the suspension of stable pumpable easily to be used by processor.A problem relevant to LMW surfactant is that the known pressure that they are increased on seed also can reduce germination.

In addition, known some insecticide for having relatively high water-soluble and/or lower fusing point is difficult to obtain stable aqueous formulation.Metalaxyl (fusing point 63-72 DEG C technical grade, water-soluble 8400ppm) is exactly so a kind of chemical substance.Obtain stable metalaxyl aqueous suspension preparation very challenging, because the method do not had crystallizes out again to prevent this chemical substance, cause physical instability in storage process.

Another problem of the mixture of ad hoc agricultural chemicals, polymer, colouring agent and other additive is used to be the agricultural chemicals and the additive that multiple application are needed to deposition and dry aequum on seed.Suitable adhesion is necessary for multiple application.

Except consuming time, the safety of these application mix things is unknown with uncertain often.Usually, need filler, such as talcum powder, to reduce phytotoxicity or to promote seed drying and handling property.As a result, process becomes difficulty, and the biological effect of seed treatment reduces.

All-embracing preparation in the art for instant and effective plant-less toxicity is still needed agricultural chemicals to be adhered to seed and eliminates the needs to being added further by subprocessors in binding agent or polymer to described application mix thing.Ideally, such preparation can in single application in continuous fluid processing and without the need to filler or anti-blocking (anti-blocking) powder.

Summary of the invention

The invention provides a kind of water-based seed treatment, comprising: a) at least one insecticide; B) at least one graft copolymer; C) at least one polyvinyl alcohol (PVA); And d) at least one plasticizer.In one embodiment, described insecticide comprises clothianidin, metconazole and metalaxyl.

In one embodiment, the present invention includes: a) at least one insecticide of about 0.2-about 15.0%; B) at least one graft copolymer of about 0.1-about 0.45%; C) at least one polyvinyl alcohol (PVA); And at least one plasticizer (all percentage is listed in the % of % by weight 100% active substances of total preparation) of d) about 5.0-about 30%.

In another embodiment, described graft copolymer can be 2500 (35% aqueous solution).

In another embodiment, described PVA can be 24-203 (24% aqueous solution).

In another embodiment, described liquid plasticizer can propane diols or hexylene glycol.In another embodiment, described plasticizer can be the mixture of propane diols and hexylene glycol.

In another embodiment, solid plasticizer can combine with liquid plasticizer and use.Suitable solid plasticizer comprises trimethylolpropane, sorbitol, urea or their any combination.

In further embodiment, described preparation can comprise extra composition, such as preservative, anion surfactant, thickener, wetting agent, defoamer, lubricant, polymer emulsion or colouring agent.

In one embodiment, described preservative can be CMIT and the MIT aqueous solution, such as cG/ICP.

In another embodiment, described anion surfactant can be lauryl sodium sulfate, such as wA-Extra (30% aqueous solution).

In another embodiment, described thickener can be xanthans, such as cC.

Described wetting agent can be in another embodiment 4894.

In another embodiment, described defoamer can be 104PG-50 or DowCorningAntifoamFG-10 or both combinations.In another embodiment, preferably 104PG-50.

In another embodiment, described lubricant can be lube156P or lube156PFP (25% aqueous emulsion).

In one embodiment, described colouring agent can be red48:2.

In one embodiment, described polymer emulsion can be ethylene-vinyl acetate copolymer, such as e-200.

In another embodiment, described aqueous agricultural-chemical preparation can comprise (except as otherwise noted, in % by weight 100% active substances of total preparation): a) at least one insecticide of about 2.0-about 15.0%; B) at least one graft copolymer of about 0.1-about 0.45%; C) at least one polyvinyl alcohol (PVA) of about 0.5-about 2.5%; D) at least one plasticizer of about 20.0-about 30.0%; E) at least one preservative (as provided) of about 0-about 0.3%; F) at least one anion surfactant of about 0-about 2.0%; G) at least one thickener of about 0-about 0.25%; H) at least one wetting agent of about 0-about 0.25%; I) at least one defoamer (as provided) of about 0-about 0.3%; J) at least one lubricant of about 0-about 2.0%; K) at least one polymer emulsion (as provided) of about 0-about 5.0%; And at least one colouring agent (as provided) of l) about 0-about 15.0%.

In another embodiment, described aqueous agricultural-chemical preparation can comprise (except as otherwise noted, in % by weight 100% active substances of total preparation): a) at least one insecticide of about 4.25%; B) at least one graft copolymer of about 0.35%; C) at least one PVA of about 1.2%; D) at least one plasticizer of about 25%; E) at least one preservative (as provided) of about 0.14%; F) at least one anion surfactant of about 0.40%; G) at least one thickener of about 0.14%; H) at least one wetting agent of about 0.176%; I) at least one defoamer (as provided) of about 0.10%; J) at least one lubricant of about 0.75%; K) at least one polymer emulsion (as provided) of about 3.0%; And l) about 10% at least one colouring agent (as provided).

In another embodiment, described aqueous agricultural-chemical preparation can comprise (except as otherwise noted, in % by weight 100% active substances of total preparation): a) clothianidin of about 1.0-about 12.0%; B) metalaxyl of about 0.2-about 4.0%; C) metconazole of about 0.1-about 2.0%; D) at least one graft copolymer of about 0.1-about 0.45%; E) at least one polyvinyl alcohol (PVA) of about 0.5-about 2.5%; F) at least one plasticizer of about 5.0-about 30.0%; G) at least one preservative (as provided) of about 0-about 0.3%; H) at least one anion surfactant of about 0-about 2.0%; I) at least one thickener of about 0-about 0.25%; J) at least one wetting agent of about 0-about 0.25%; K) at least one defoamer (as provided) of about 0-about 0.3%; L) at least one lubricant of about 0-about 2.0%; M) at least one polymer emulsion (as provided) of about 0-about 5.0%; And at least one colouring agent (as provided) of n) about 0-about 15.0%.

In another embodiment, described aqueous agricultural-chemical preparation can comprise (except as otherwise noted, in % by weight 100% active substances of total preparation): a) the industrial clothianidin (active ingredient of 97.5%) of about 3.01%; B) the industrial metalaxyl (active ingredient of 97.0%) of about 0.907%; C) the industrial metconazole (active ingredient of 97.0%) of about 0.454%; D) at least one graft copolymer of about 0.35%; E) at least one PVA of about 1.2%; F) at least one plasticizer of about 25.0%; G) at least one preservative (as provided) of about 0.14%; H) at least one anion surfactant of about 0.4%; I) at least one thickener of about 0.14%; J) at least one wetting agent of about 0.176%; K) at least one defoamer (as provided) of about 0.10%; L) at least one lubricant of about 0.75%; M) at least one polymer emulsion (as provided) of about 3.0%; And n) about 10.0% at least one colouring agent (as provided).

Whole embodiment of the present invention comprises the water being enough to form viscosity needed for described preparation.Each preparation can be water to the surplus of described preparation 100 % by weight.

In last embodiment, the present invention relates to the method preparing preparation, comprise and prepare thickener pre-composition, prepare the mixture of metconazole and metalaxyl, prepare clothianidin suspension, then mix the mixture of other compositions, described thickener pre-composition, described metconazole and metalaxyl and described clothianidin suspension.The method that another kind prepares preparation comprises prepares thickener pre-composition, prepares the suspension of clothianidin-containing, metalaxyl and metconazole, then mixes other compositions, described thickener pre-composition and described clothianidin, metalaxyl and metconazole suspension.

Disclosed embodiment is the simple examples embodiment of the present invention disclosed herein design, should not be regarded as restriction, except statement of being far from it.

detailed Description Of The Invention

The present invention relates to a kind of preparation containing insecticide, it is formulated to be provided in storage process and keeps stablizing and providing the instant of excellent seed pelleting agricultural mixture.Described seed pelleting is that seed provides the protection of better pest control.

Applicant finds that instant preparation of the present invention is stable with plant-less toxicity.Preparation of the present invention is especially easily to terminal use, because they do not need dilution before being applied to seed.

In whole specification, term " plant propagation material " and " seed " usual commutative use.

Term " as provided " refers to that the form that the weight of the described formulation ingredients indicated by weight is supplied to consumer with manufacturer in invention required for protection exists.These are different from 100% pure component product.

Preparation of the present invention can be used for the suspending concentrate preparing insecticide, fungicide and their mixture.Disclosed preparation can use in " according to itself ", or mixes with other additives, or dilute with water uses.But they self or be together applied to seed with other agricultural chemicals or additive.

Now, the various compositions of disclosed preparation will be discussed in detail.

insecticide

Insecticide, comprises insecticide according to the spendable insecticide of the present invention; Include but not limited to that anabasine insecticide is as clothianidin (can buy to SumitomoChemicalCo.), Imidacloprid, Diacloden, Acetamiprid and thiacloprid; Antibiotics insecticide, as Avermectin, emamectin-benzoate and A83543A and B; Carbamates insecticide, as bendiocarb, sevin, carbofuran, Aphox, Mobucin, methiocarb, thiodicarb; Pyrethroid insecticide, as acrinathrin, decis; Phenyl pyrazoles insecticide, as second worm nitrile, ethiprole; Organochlorine class insecticide, as 5a,6,9,9a-hexahydro-6,9-methano-2,4; Organic phosphor (organophophorus) class insecticide, as Resistox; Diamide insecticide, as Rynaxypyr, fipronil bisamide; Benzoyl area kind insecticide, as bistrifluron, chlorfluazuron (chlofluazuron), diflubenzuron, flucycloxuron, HEXAFLUMURON, Rimon, Teflubenzuron, triflumuron; Insect growth regulator, IGR, as Buprofezin and the similar kind of insecticide.

Can comprise fungicide by insecticide used according to the invention, include but not limited to that antibiotic fungicide is as antimycin A1, methoxy acrylic fungicide is as Fluoxastrobin, dimoxystrobin, fluoxastrobin, kresoxim-methyl, carbamates fungicide is as benzene metsulfovax, carbendazim, the mould prestige of second, iprovalicarb, thiophanate methyl, dicarboximide class fungicide is as difoltan, captan, Famoxate, folpet, iprodione, procymidone, vinclozolin, triazole type fungicide is as bitertanol, bromuconazole, cyproconazole, diclobutrazol, Difenoconazole, olefin conversion, epoxiconazole, RH-7592, Fluquinconazole, Flutriafol, own azoles alcohol, glyoxalin, plant bacterium azoles, metconazole (can buy to Kureha company), prothioconazoles, simeconazoles, Tebuconazole, triazolone, triadimenol, triticonazole, amide-type fungicide is as Boscalid, carboxin, ring propionyl bacterium amine, two chlorine zarilamid (dicyclomet), Guardian, fenfuram, fenhexamid, flusulfamide, flutolanil, furametpyr, mebenil, ofurace, Wakil, pyracarbolid, thifluzamide, tiadinil, zoxamide, aromatic fungicide is as chloroneb, tpn, imidazole fungicides is as cyazofamid, Fenamidone, triazoxide, aliphatic nitrogen fungicide is as white urea cyanogen, and morpholine class fungicide is as dimethomorph, and pyrimidine fungicide is as Fenarimol, mepanipyrim, nuarimol, phonetic mould amine, pyroles fungicide is as fenpiclonil, fludioxonil, pyridines fungicide is as fluazinam, fluopicolide, benzimidazole fungicide is as fuberidazole, thiabendazole, dithiocarbamates fungicide is as mancozeb, maneb, tmtd, ziram, quinolines fungicide is as quinoxyfen, aromatic fungicide is as pcnb, miscellaneous (non-classified) fungicide is as diclomezine, Delan, Pencycuron, pyroquilon, tricyclazole, 2-[2-(2, 5-dimethyl Phenoxymethyl) phenyl]-2-methoxy N-methylacetamide, aromatic hydrocarbon: chlorphenyl fungicide is as tolelofos-methyl, phenyl amide: acylalaninies (acylalanine) class fungicide such as metalaxyl (can purchased from NufarmLtd. or LGLifeSciences, Ltd.), metalaxyl-M, M 9834, M 9834-M and furalaxyl-M, with the fungicide of correlation type.

Term " insecticide " and " fungicide " widely use and are intended to cover the compound of all positive opposing insects and fungi.Described compound can belong to the compounds category of wide region.The insecticide used in preparation prepared in accordance with the present invention can be is selected to control a large amount of insect, insect and/or the insecticide of fungi and the combination of fungicide by a kind of preparation of use.In addition, can expect that preparation prepared in accordance with the present invention also can comprise the auxiliary insecticide not meeting requirement of the present invention, as long as these auxiliary insecticides are compatible with described preparation, as determined in the compatibility test by being familiar with those skilled in the art known.Such as, water soluble insecticide may be dissolved in the dispersion not affecting the original solid insecticide of theme of the present invention in the water carrier of described preparation use.Another example of auxiliary insecticide is the insecticide of sealing, and wherein water-insoluble liquid or low melting point insecticide and/or fungicide are wrapped up or are wrapped in by solid shell in solid matrix, are then added in preparation described herein.

Preferably use the mixture of insecticide and fungicide in the present invention.Mixture such as, by various factors, crops, geographic area, insect frequency spectrum (spectrum) and pressure, and drug-fast prevalence rate.

In mixture, preferred insecticide is anabasine insecticide such as clothianidin at present, and triazole type fungicide is as metconazole, and phenyl amide: acylalaninies fungicide is as metalaxyl.

As previously mentioned, be difficult to obtain the stable aqueous formulation containing metalaxyl, because metalaxyl forms unwanted crystal.Inventor is surprised to find that preparation of the present invention provides the solution of the excellence of this known problem in this area.

polyvinyl alcohol (PVA)

Polyvinyl alcohol (PVA) is a kind of water-soluble synthetic polymer.The PVA of many different brackets is commercially available.Although most of available PVA polymer can be used for the present invention, preferred PVA grade has " ultralow ", " low " and " medium " viscosity grade.Usually by the viscosity of 4%PVA solution, they are classified.The viscosity of these PVA grades is usual between about 2.5cP (centipoise) to about 3.2cP (centipoise) at 20 DEG C.Most preferred grade is " ultralow " and " low " viscosity grade.

The PVA mean molecule quantity that the present invention comprises is about 12,500g/mole-about 125,000g/mole.Each polymer grade has molecular weight distribution.Weight average molecular weight is defined as the weight fraction that molecular weight is multiplied by the molecule with this molecular weight, and described weight fraction is molecular weight whole in total distribution, divided by total molecular weight.In addition, described PVA polymer can (98-100%), medium (90-98%) or part (70-90%) hydrolysis completely.The PVA polymer of partial hydrolysis is most preferred.Also can use modification or specific class PVA polymer.The PVA of above-mentioned disclosed range of viscosities can be carboxylation or sulfonation to introduce the anion characteristic that some promote viscosity and dispersion powders.The PVA of these grades has the carboxyl (-CO that some are added into PVA chain simply ₂x group) or sulfonic group (-SO ₃x group), wherein X can be H or alkali metal.

In a preferred embodiment, PVA is 24-203, it can purchased from SekisuiSpecialtyChemicalsAmerica.

graft copolymer

Graft copolymer is the material of the polymer chain with a kind of chemical composition that grafting from main polymer chain goes out, and described main polymer chain has different chemical compositions.Acrylic acid, methacrylic acid, acrylate, methacrylate or methylmethacrylate polymer is included but not limited to according to the spendable graft copolymer of the present invention, it has the another kind of polymer chain stretched out from acrylate polymer main chain, such as, polyethers is as polyethylene glycol.

In a preferred embodiment, this graft copolymer is have acrylic acid, methacrylic acid, acrylate, methacrylate or methylmethacrylate polymer main chain and the pectination branched polymer from hydrophilic polyethylene glycol (PEG) branch that this main chain stretches out.In two-dimensional representation, described PEG branch is perpendicular to acrylate polymer main chain (normally linear) drawing and be similar to the tooth of comb, causes the description of " pectination branch ".Pectination branch used in the present invention graft copolymer is proprietary material, and therefore, inventor does not know their composition and the detail of preparation.

In a preferred embodiment, described pectination branch graft copolymer is 2500 (about 35% graft copolymer solution, from HuntsmanCorp.)

pVA-graft copolymer combines

Collaborative PVA and the combination of graft copolymer are the mixtures of these two kinds of polymer.The combination of PVA-graft copolymer is used to have many good qualities.

First, the coated insecticide that uses in the formulation of described combination of polymers the protective layer between insecticide and seed is provided.This protective layer reduces any phytotoxicity that insecticide can have.

Secondly, the water soluble polymer material used in invention formulation provides slower absorption and transfer for insecticide enters in seed.Prior art preparation uses composition to enter absorption in seed and transfer to strengthen insecticide usually.But, absorb any toxicity can aggravated surfactant and insecticide and may have fast, thus reduce and germinate.

In addition, described PVA-graft copolymer combination is very soluble in water and is safe to seed.The seed coated with film formed by preparation of the present invention can easily by soil moisture again hydration.Described film does not work as limiting factor to the transport in seed at moisture.The normal hydrophilic layer of seed is retained and remains on the governing factor in neutron absorption moisture.Therefore, good seed sprouting and dressing adhesion is maintained.

Moreover described PVA-graft copolymer combination is compatible with the dispersant system used in many commercial polymer emulsions.This compatibility allows to be directly incorporated in seed treatment formulations by polymer emulsion in the preparation not lose stability.

plasticizer

As used herein, term " plasticizer " refers to the material of the film produced by described preparation for modification, dry faster to allow, and gives higher water sensitivity and do not need to damage the viscosity of seed in the mobility processed and in plantation equipment.

Be generally low-molecular-weight alkyl glycol or polyalcohol (dihydroxylic alcohols or trihydroxylic alcohol) according to the spendable liquid plasticizer of the present invention, the length of alkyl is wherein 2-6 carbon atom.Preferred liquid plasticizer comprises propane diols and hexylene glycol.

Solid plasticizer also can combine with liquid plasticizer and use.The instantiation of suitable solid plasticizer includes but not limited to trimethylolpropane, sorbitol, urea or their any combination.The blend comprising liquid and solid plasticizer is preferred at present.Such blend can comprise propane diols, hexylene glycol, urea and trimethylolpropane.

polymer emulsion

When adhesion requirements height maybe when needs high coverage rate, the polymer emulsion (or latex) that can add based on polyvinyl acetate and/or ethylene vinyl acetate copolymer adheres to and seed outward appearance to improve.

The advantage of invention formulation is them is " all-embracing ", and namely they allow to add polymer emulsion when prepared by preparation, instead of add them at application site.Therefore, do not sacrifice parcel stability and do not damage the absorption of seed moisture content.

The polymer emulsion that can be used in invention formulation is stable by PVA, and is therefore that PVA is compatible.Polymer emulsion can be added in preparation " dispersant shock (shock) " that do not cause and unwanted viscosity or gel can be caused to increase.In addition, because the stabilizing agent for preparation suspension and polymer emulsion or latex is similar, when they mix, dispersant does not peel off from latex particle or insecticide granule.Result obtains stable low viscosity mixtures.This mixture can on seed depositing biocides and polymer and do not need extra composition.

In addition, polymer emulsion can be used for preventing from around seed, form unwanted damp-proof layer.Usually, the film of the latex dispersions containing q.s PVA can again disperse in water.But when LMW surfactant is present in seed treatment formulations, their micella absorption PVA, consumes the PVA that can be used for wrapping up latex, polymer emulsion or insecticide granule.Therefore, the permanent not redispersible film as damp-proof layer can be formed.PVA-graft polymers is combined in around latex particle and forms protective layer.Then this protective layer can form the film suppressing described film to be formed or make it disperse again.Therefore, permanent damp-proof layer is not formed.Therefore, preparation of the present invention can be eliminated or alleviate the bad reaction to dispersion stabilization and seed sprouting of the LMW surfactant that exists in the prior art.

In a preferred embodiment, can use e-200 (CelaneseLtd.) polymer emulsion.

wetting agent and other additive

In one embodiment, described preparation comprises wetting agent.The wetting agent that majority is purchased object used in the present invention.

The concentration of wetting agent should be realize the Cmin needed for good wet and film forming.When adding suitable wetting agent, described preparation strain is wet and forms good film.Usually, suitable wetting agent is functional under the amount of the 0.2wt% or lower of total preparation.

In a preferred embodiment, described wetting agent is produced by HuntsmanCorporation 4894 (about 88% solids).

In another embodiment, preparation of the present invention to be included in similar formulations typical additive to improve parcel and handling property.

Preferred additive comprises:

Organic thickening agent, such as, is produced by CPKelco cC (xanthans);

Lubricant, antiblocking agent, such as can purchased from MichelmanInc.'s lube156P or lube156PFP (wax emulsion).

Defoamer, such as, produced by AirProductsandChemicals, Inc. 104PG (solution of tetramethyl-5-decine-4,7-glycol in propane diols of 50%).

Preservative, such as can purchased from RohmandHaasCompany's cG/ICP (CMIT and the MIT aqueous solution); With

Anion surfactant, such as can purchased from Stepan's wA-Extra (lauryl sodium sulfate).

Further, colouring agent also can be added into the seed being enclosed with agricultural chemicals in disclosed preparation with mark.In a preferred embodiment, colouring agent is used red48:2 (from SunChemical).

Invention also relates to the method for described formulation application in seed.Seed treatment application technology is that those skilled in the art are known, and can use them easily in the context of the present invention.Composition of the present invention also can be used as suspending agent or impregnating (soak) application.Also film dressing and parcel can be used.Coating process is known in this area and uses the technology such as film dressing, parcel, immersion.Can change the application method of composition of the present invention, and the present invention is intended to comprise any technology will used by those skilled in the art.

The invention still further relates to the method for protection seed from insect pest, it comprises the formulation application of the present invention of effective dose in seed.

The wording of " effective dose " of preparation means that the preparation of q.s is to provide required effect.In general, said preparation uses the amount of spermatophyte toxicity damage not suppress seminal propagation and not cause.The amount of described preparation can according to specific crops and other factors vary.The necessary amount of described preparation is determined very well in those of ordinary skill in the art.

Two kinds of prevailing application methodes are suspending agent process and directly process.Each method all can with special seed-treating apparatus.Direct processor directly uses preparation described in metering instrument on seed without dilution.The water-reducible suspending agent that suspending agent processor instrument dosage is formed by described seed treatment formulations.

As used herein, the numerical value of all amounts of relating to, percetage by weight etc., is defined as " about (about) " or " about (approximately) " each particular value, increase and decrease 10%.Such as, wording " at least 5.0wt% " is interpreted as " at least 4.5wt%-5.5wt% ".Therefore, the scope of claim is included in the amount in 10% scope of value required for protection.

The following examples are intended to illustrate how the present invention and instruction those skilled in the art prepare and use the present invention.They are not intended to limit the present invention by any way.

Embodiment

embodiment 1

prepare seed treatment formulations

Use program below to prepare seed treatment formulations, there is the amount represented with percetage by weight and lb/gal manufactured goods listed in following table 1.

Table 1

preparation cC pre-composition

First, by by deionized water and cG/ICP is added in the little mixing channel being equipped with high-shear mixer and prepares 1.5% cC pre-composition.Under running blender with 3000rpm, add cC and mix at least 1h to guarantee the dispersion that CC is suitable and aquation.The amount of each adding ingredient is listed in the following Table 2.

Table 2

prepare metalaxyl/metconazole solution

Then, metalaxyl and metconazole solution is prepared.Propane diols and hexylene glycol are added into and are equipped with in the mixing channel of blender.When to be enough to the speed mixing maintaining whirlpool, add metalaxyl and metconazole.Mix described solution until it is for clarification and uniform.Optionally, this solution to 40 can be heated DEG C to accelerate rate of dissolution, but the temperature of solution should not more than 50 DEG C.The amount of each adding ingredient is listed in the following Table 3.

Table 3

prepare clothianidin suspending agent

Prepare clothianidin suspending agent.Deionized water is added into and is equipped with in the mixing channel of high-shear mixer.When mixing under the speed keeping whirlpool, add 2500, 4894 Hes 104PG-50.Mix described mixture 10min or until it is for homogeneous phase.Then, adding portion pre-composition also mixes 20min or until it is for homogeneous phase.Then increase blender speed to provide high shear and whirlpool, add clothianidin gradually simultaneously.Add clothianidin speed slowly to avoid powder and gather on surface.Mix the extra 20min of described suspending agent or until clothianidin disperses completely.Optionally, by suspending agent described in embedded (in-line) super mixer recycle to promote dispersion process.List the amount of each composition in the following Table 4.

Table 4

Then with being equipped with the little medium grinder of 0.8-1.0mm ceramic dielectric that clothianidin suspending agent is ground to target median particle diameter.Such as, zirconium silicate or zirconia can be used.Also any little medium grinder realizing the equivalence of required particle diameter can be used.

prepare manufactured goods

Finally, manufactured goods are prepared.Deionized water is added into and is equipped with in the main mixing channel of high-shear mixer.Arranging under the speed keeping whirlpool, add 24-203 also mixes until homogeneous phase or 15min.Dilute completely 24-203 precipitates to prevent PVA.When combined, add 2500, 4893 Hes in 104PG-50 to described groove.Then add lube156P and in E-200 to described groove.

Then blender speed is increased to provide high shear and whirlpool.Slowly add in clothianidin suspending agent to described groove within the time of at least 15min.Then, slowly add in metalaxyl and metconazole solution to described groove.Stir described mixture at least 15min under high shear.

When running described blender under low sheraing has whirlpool, add wA-Extra and red48:2.Then described mixture 30min or until homogeneous phase is mixed.Finally, add cC pre-composition also mixes until preparation is homogeneous phase.If necessary, extra water can be added with adjusting viscosity.The amount of each adding ingredient is listed below in table 5.

Table 5

embodiment 2

prepare seed treatment formulations

Use program below to prepare seed treatment formulations, there is the amount represented with percetage by weight and lb/gal manufactured goods listed in following table 6.

Table 6

preparation cC pre-composition

First, by by deionized water and cG/ICP is added in the little mixing channel being equipped with high-shear mixer and prepares 1.5% cC pre-composition.Under running blender with 3000rpm, add cC and mix at least 1h to guarantee the dispersion that CC is suitable and aquation.The amount of each adding ingredient is listed in following table 7.

Table 7

prepare clothianidin/metalaxyl/metconazole suspending agent

Prepare described three kinds of active component suspending agents.Deionized water is added into and is equipped with in the mixing channel of high-shear mixer.When mixing under the speed keeping whirlpool, add 2500, 4894, DowCorningFG-10 defoamer and 104PG-50.Mix described mixture 10min or until it is for homogeneous phase.Then, adding portion pre-composition also mixes 20min or until it is for homogeneous phase.Then increase blender speed to provide high shear and whirlpool, add clothianidin, metalaxyl and metconazole gradually simultaneously.Add described solid matter speed slowly to avoid powder and gather on surface.Mix the extra 20min of described suspending agent or until described solid active agent disperses completely.Optionally, by suspending agent described in embedded super mixer recycle to promote dispersion process.List the amount of each adding ingredient in the following Table 8.

Table 8

Then with being equipped with the little medium grinder of 0.8-1mm ceramic dielectric that described suspending agent is ground to target median particle diameter.Such as, zirconium silicate or zirconia can be used.Also any little medium grinder realizing the equivalence of required particle diameter can be used.

prepare manufactured goods

Finally, manufactured goods are prepared.Deionized water is added into and is equipped with in the main mixing channel of high-shear mixer.Arranging under the speed keeping whirlpool, add 24-203 also mixes until homogeneous phase or 15min.Dilute completely 24-203 precipitates to prevent PVA.When combined, propane diols, hexylene glycol, trimethylolpropane, urea and remaining is added 2500, 4894 Hes in 104PG-50 to described groove.Then add lube156P and in E-200 to described groove.

Then blender speed is increased to provide high shear and whirlpool.Slowly add within the time of at least 15min in clothianidin/metalaxyl/metconazole suspending agent to described groove.Then, slowly add in metalaxyl and metconazole solution to described groove.Stir described mixture at least 15min under high shear.

When running described blender under low sheraing has whirlpool, add red48:2.Then described mixture 30min or until homogeneous phase is mixed.Finally, surplus is added cC pre-composition also mixes until preparation is homogeneous phase.If necessary, extra water can be added with adjusting viscosity.The amount of each adding ingredient is listed below in table 9.

Table 9

embodiment 3

prepare seed treatment formulations

Use program below to prepare seed treatment formulations, there is the amount represented with percetage by weight and lb/gal manufactured goods listed in following table 10.

Table 10

preparation 20320% solution

First, 20% is prepared 203 aqueous solution.Deionized water is added into and its contents can be heated in the little mixing channel of at least 100 DEG C.When to keep the speed of whirlpool to mix, add solid 203 in described groove.Then under continuous mixing described mixture is heated to 90 DEG C until 203 dissolve completely.Described mixture is cooled to environmental temperature.The amount of each adding ingredient is listed in following table 11.

Table 11

preparation cC pre-composition

Then, by by deionized water and cG/ICP is added in the little mixing channel being equipped with high-shear mixer and prepares 1.5% cC pre-composition.Under running blender with 3000rpm, add cC and mix at least 1h to guarantee the dispersion that CC is suitable and aquation.The amount of each adding ingredient is listed in following table 12.

Table 12

prepare clothianidin/metalaxyl/metconazole suspending agent

Prepare described three kinds of active component suspending agents.Deionized water is added into and is equipped with in the mixing channel of high-shear mixer.When mixing under the speed keeping whirlpool, add 2500, 4894 Hes 104PG-50.Mix described mixture 10min or until it is for homogeneous phase.Then, adding portion pre-composition also mixes 20min or until it is for homogeneous phase.Then increase blender speed to provide high shear and whirlpool, add clothianidin, metalaxyl and metconazole gradually simultaneously.Add described solid matter speed slowly to avoid powder and gather on surface.Mix the extra 20min of described suspending agent or until described solid active agent disperses completely.Optionally, by suspending agent described in embedded super mixer recycle to promote dispersion process.List the amount of each adding ingredient in the following Table 13.

Table 13

prepare manufactured goods

Finally, manufactured goods are prepared.Deionized water is added into and is equipped with in the main mixing channel of high-shear mixer.Arranging under the speed keeping whirlpool, add 20% 203 solution also mix until homogeneous phase or 15min.Dilute completely 24-203 solution precipitates to prevent PVA.When combined, propane diols, trimethylolpropane, urea and surplus is added 2500, 4894 Hes in 104PG-50 to described groove.Then add lube156P and in E-200 to described groove.

Then blender speed is increased to provide high shear and whirlpool.Slowly add within the time of at least 15min in clothianidin/metalaxyl/metconazole suspending agent to described groove.Stir described mixture at least 15min under high shear.

When running described blender under low sheraing has whirlpool, interpolation surplus cC pre-composition also mixes until preparation is homogeneous phase.If necessary, extra water can be added with adjusting viscosity.The amount of each adding ingredient is listed below in table 14.

Table 14

embodiment 4

prepare seed treatment formulations

Use program below to prepare seed treatment formulations, there is the amount represented with percetage by weight and lb/gal manufactured goods listed in following table 15.

Table 15

preparation 20320% solution

First, 20% is prepared 203 aqueous solution.Deionized water is added into and its contents can be heated in the little mixing channel of at least 100 DEG C.When to keep the speed of whirlpool to mix, add solid 203 in described groove.Then under continuous mixing described mixture is heated to 90 DEG C until 203 dissolve completely.Described mixture is cooled to environmental temperature.The amount of each adding ingredient is listed in following table 16.

Table 16

preparation cC pre-composition

Then, by by deionized water and cG/ICP is added in the little mixing channel being equipped with high-shear mixer and prepares 1.5% cC pre-composition.Under running blender with 3000rpm, add cC and mix at least 1h to guarantee the dispersion that CC is suitable and aquation.The amount of each adding ingredient is listed in following table 17.

Table 17

prepare metalaxyl/metconazole solution

Prepare metalaxyl and metconazole solution.Propane diols and hexylene glycol are added into and are equipped with in the mixing channel of blender.When to be enough to the speed mixing maintaining whirlpool, add metalaxyl and metconazole.Mix described solution until it is for clarification and uniform.Optionally, this solution to 40 can be heated DEG C to accelerate rate of dissolution, but the temperature of solution should not more than 50 DEG C.The amount of each adding ingredient is listed in following table 18.

Table 18

prepare clothianidin suspending agent

Prepare clothianidin suspending agent.Deionized water is added into and is equipped with in the mixing channel of high-shear mixer.When mixing under the speed keeping whirlpool, add 2500, 4894 Hes 104PG-50.Mix described mixture 10min or until it is for homogeneous phase.Then, adding portion pre-composition also mixes 20min or until it is for homogeneous phase.Then increase blender speed to provide high shear and whirlpool, add clothianidin gradually simultaneously.Add solid matter speed slowly to avoid powder and gather on surface.Mix the extra 20min of described suspending agent or until clothianidin disperses completely.Optionally, by suspending agent described in embedded super mixer recycle to promote dispersion process.List the amount of each composition in the following Table 19.

Table 19

prepare manufactured goods

Finally, manufactured goods are prepared.Deionized water is added into and is equipped with in the main mixing channel of high-shear mixer.Arranging under the speed keeping whirlpool, add 20% 203 solution also mix until homogeneous phase or 15min.Dilute completely 24-203 solution precipitates to prevent PVA.When combined, add 2500, 4894 Hes in 104PG-50 to described groove.Then add in Lube156P to described groove.

Then add red48:2.Finally, surplus is added cC pre-composition also mixes until preparation is homogeneous phase.If necessary, extra water can be added with adjusting viscosity.The amount of each adding ingredient is listed below in table 20.

Table 20

embodiment 5

Seeds secure and efficacy test are carried out to preparation of the present invention.Preparation of the present invention provides excellent seeds secure and the available protecting of anti-seed and seedling disease and insect.In addition, described seed treatment reduces active component and inert substance dust removal (dust-off) from handled seed.Effect business seed treatment standard known with the personnel being familiar with seed industry with untreated seed is compared.

seeds secure

Cold, the gentle cold germination test utilizing the standard method that uses in seed industry to implement processed wheat seed is to verify that preparation of the present invention is safe to seed.Within 6 months, measure after treatment and germinate, result shows in following table 21.The preparation of the result display embodiment 2 of three tests does not reduce germination, but obtains the germination value equaling undressed seed.

Table 21

Winter wheat germination studies

3 years are stored after treatment with the Wheat and barley seed of identical method for treating seeds process.The display of temperature germination test, the preparation of embodiment 2 is seed safety and similar to untreated seed in the storage of 3 years.Negative effect is not observed in germination test.

Table 22

anti-seed/seedling disease effect

experiment 1

In the work place study of the field performance and seedling protection that are intended to preparation anti-wheat crown rot bacterium (Fusariumpseudograminearum) assessing embodiment 2, when planting, the inoculum of pathogene is placed on and has in the seed furrow of wheat seed.Plant untreated seed when having and not there is inoculum and to build up harm influence in (standestablishment), seedling vigor (height and plant health rate) and output with assessment at standing forest.The preparation of research display embodiment 2 has significant standing forest relative to the process of untreated inoculation to be improved, and has the standing forest identical with untreated nonvaccinated process with the product of two kinds of ratios application and set up.The plant height of the preparation of embodiment 2 and motility grade are also significantly better than the process of untreated inoculation and equal untreated nonvaccinated process.The fungicide protection that the ultimate output evaluation certificate of process provides in the preparation of embodiment 2, in the effect controlling wheat crown rot bacterium, has an increase of 11.4 – 11.7Bu/A relative to the process of untreated inoculation.

Table 23

With the spring wheat test of wheat crown rot bacterium inoculation

test 2

In test, the preparation of embodiment 2 provides the excellent activity of the anti-loose smut of barley caused by pathogene, wheat loose smut at the scene.Standing forest in process is set up and is not shown significant difference.The numerical value providing 3.16-5.33Bu/A relative to untreated barley from the preparation of the yield data display embodiment 2 of research increases.

Table 24

Spring barley loose kernel smut (wheat loose smut) is tested

anti-seed/seedling insect effect

Wireworm to be lived in field soil with the seedling of seed and germination as food, causes causing crops field standing forest to set up the plant damage of loss.Wherein find in field that, in the spring wheat test of wireworm, undressed wheat standing forest is significantly inferior to the process of the combination of all fungicide, insecticide or fungicide and insecticide what implement.When with metalaxyl or metconazole process seed, every 0.25m ²remarkable increase by 1 strain plant.Independent clothianidin process is than untreated many 2.7 strain plants.The preparation of the embodiment 2 of two kinds of ratios testing provides standing forest best in evaluated process used and sets up, and gives the increase of significant 5.2 strain plants relative to untreated and be significantly better than independent fungicide or independent clothianidin.

Table 25

Spring wheat is tested.When planting, field soil is naturally large quantities of grows wireworm.

the dust reducing the active component/inert substance of process seed is removed

Retain with the Heubach dust meter dust implemented on process seed and measure.Such method allows the assessment of preparation in seed coat retentive activity composition, eliminates the dust in environment in operating process.The preparation dust values of embodiment 2 is equal to or less than untreated seed.

Table 26

The Heubach dust meter of the Jagger wheat of process is measured.

traits of yield is studied

Following table provides the traits of yield in winter wheat test.Phytophthira is considered to the insect of field trial.The preparation of embodiment 1 provides by effectively controlling described insect the output added.

Table 27

Winter wheat is studied.Phytophthira is considered as field trial insect.

Claims

1. a water-based seed treatment formulations, it comprises (except as otherwise noted, in % by weight 100% active substances of total preparation):

A) at least one insecticide of about 0.2-about 15.0%;

B) at least one graft copolymer of about 0.1-about 0.45%;

C) at least one polyvinyl alcohol (PVA); With

D) at least one plasticizer of about 5.0-about 30%.

2. preparation according to claim 1, wherein said insecticide is clothianidin.

3. preparation according to claim 2, also comprises insecticide metconazole.

4. preparation according to claim 3, also comprises insecticide metalaxyl.

5. preparation according to claim 1, wherein said graft copolymer is

6. preparation according to claim 1, wherein said PVA is

7. preparation according to claim 1, wherein said at least one plasticizer is the mixture of propane diols and hexylene glycol.

8. preparation according to claim 1, also comprises at least one thickener, wetting agent, defoamer, lubricant, polymer emulsion, preservative, anion surfactant or colouring agent.

9. preparation according to claim 8, wherein said thickener is xanthans.

10. preparation according to claim 9, wherein said thickener is

11. preparations according to claim 8, wherein said wetting agent is

12. preparations according to claim 8, wherein said defoamer is

13. preparations according to claim 8, wherein said lubricant is 156P.

14. preparations according to claim 8, wherein said colouring agent is

15. preparations according to claim 8, wherein said polymer emulsion is ethylene-vinyl acetate copolymer.

16. preparations according to claim 15, wherein said polymer emulsion is

17. 1 kinds of aqueous agricultural-chemical preparations, it comprises (except as otherwise noted, in % by weight 100% active substances of total preparation):

A) at least one insecticide of about 2.0-about 15.0%;

B) at least one graft copolymer of about 0.1-about 0.45%;

C) at least one polyvinyl alcohol (PVA) of about 0.5-about 2.5%;

D) at least one plasticizer of about 20.0-about 30.0%;

E) at least one preservative (as provided) of about 0-about 0.3%;

F) at least one anion surfactant of about 0-about 2.0%;

G) at least one thickener of about 0-about 0.25%;

H) at least one wetting agent of about 0-about 0.25%;

I) at least one defoamer (as provided) of about 0-about 0.3%;

J) at least one lubricant of about 0-about 2.0%;

K) at least one polymer emulsion (as provided) of about 0-about 5.0%;

L) at least one colouring agent (as provided) of about 0-about 15.0%; With

M) surplus of described preparation is water, to total 100 % by weight.

18. aqueous agricultural-chemical preparations according to claim 17, it comprises (except as otherwise noted, in % by weight 100% active substances of total preparation):

A) at least one insecticide of about 4.25%;

B) at least one graft copolymer of about 0.35%;

C) at least one PVA of about 1.2%;

D) at least one plasticizer of about 25.0%;

E) at least one preservative (as provided) of about 0.14%;

F) at least one anion surfactant of about 0.4%;

G) at least one thickener of about 0.14%;

H) at least one wetting agent of about 0.176%;

I) at least one defoamer (as provided) of about 0.10%;

J) at least one lubricant of about 0.75%;

K) at least one polymer emulsion (as provided) of about 3.00%; With

L) at least one colouring agent (as provided) of about 10%; With

M) surplus of described preparation is water, to total 100 % by weight.

19. 1 kinds of aqueous agricultural-chemical preparations, it comprises (except as otherwise noted, in % by weight 100% active substances of total preparation):

A) clothianidin of about 1.0-about 12.0%;

B) metalaxyl of about 0.2-about 4.0%;

C) metconazole of about 0.1-about 2.0%;

D) at least one graft copolymer of about 0.1-about 0.45%;

E) at least one polyvinyl alcohol (PVA) of about 0.5-about 2.5%;

F) at least one plasticizer of about 5.0-about 30.0%;

G) at least one preservative (as provided) of about 0-about 0.3%;

H) at least one anion surfactant of about 0.1-about 2.0%;

I) at least one thickener of about 0-about 0.25%;

J) at least one wetting agent of about 0-about 0.25%;

K) at least one defoamer (as provided) of about 0-about 0.3%;

L) at least one lubricant of about 0-about 2.0%;

M) at least one polymer emulsion (as provided) of about 0-about 5.0%;

N) at least one colouring agent (as provided) of about 0-about 15.0%;

O) surplus of described preparation is water, to total 100 % by weight.

20. aqueous agricultural-chemical preparations according to claim 19, it comprises (except as otherwise noted, in % by weight 100% active substances of total preparation):

A) the industrial clothianidin (active ingredient of 97.5%) of about 3.01%;

B) the industrial metalaxyl (active ingredient of 97.0%) of about 0.907%;

C) the industrial metconazole (active ingredient of 97.0%) of about 0.454%;

D) at least one graft copolymer of about 0.35%;

E) at least one PVA of about 1.2%;

F) at least one plasticizer of about 25.0%;

G) at least one preservative (as provided) of about 0.14%;

H) at least one anion surfactant of about 0.4%;

I) at least one thickener of about 0.14%;

J) at least one wetting agent of about 0.176%;

K) at least one defoamer (as provided) of about 0.10%;

L) at least one lubricant of about 0.75%;

M) at least one polymer emulsion of about 3.00%;

N) at least one colouring agent (as provided) of about 10.0%; With

O) surplus of described preparation is water, to total 100 % by weight.

The method of 21. preparation preparation according to claim 20, it comprises

A) thickener pre-composition is prepared;

B) mixture of metconazole and metalaxyl is prepared;

C) clothianidin suspending agent is prepared; With

D) mixture and the clothianidin suspension of described thickener pre-composition, metconazole and metalaxyl is mixed.