CN105112550B - 作为骨质疏松症诊治靶标的mtus1基因 - Google Patents
作为骨质疏松症诊治靶标的mtus1基因 Download PDFInfo
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- CN105112550B CN105112550B CN201510628024.6A CN201510628024A CN105112550B CN 105112550 B CN105112550 B CN 105112550B CN 201510628024 A CN201510628024 A CN 201510628024A CN 105112550 B CN105112550 B CN 105112550B
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- mtus1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/108—Osteoporosis
Abstract
Description
实验组 | OD值(光密度) |
正常+pcDNA3.1 | 0.1704±0.003 |
骨质疏松+pcDNA3.1 | 0.0956±0.004 |
骨质疏松+pcDNA3.1-MTUS1 | 0.1529±0.003 |
Claims (7)
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CN201510628024.6A CN105112550B (zh) | 2015-09-28 | 2015-09-28 | 作为骨质疏松症诊治靶标的mtus1基因 |
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CN201510628024.6A CN105112550B (zh) | 2015-09-28 | 2015-09-28 | 作为骨质疏松症诊治靶标的mtus1基因 |
Publications (2)
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CN105112550A CN105112550A (zh) | 2015-12-02 |
CN105112550B true CN105112550B (zh) | 2018-08-07 |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106148520A (zh) * | 2016-07-06 | 2016-11-23 | 西北工业大学 | Macf1基因及其表达产物在制备诊断和治疗骨质疏松症药物中的应用 |
CN109486934A (zh) * | 2018-10-18 | 2019-03-19 | 中国医学科学院北京协和医院 | Cwf19l2基因在制备诊断骨质疏松症产品中的应用 |
CN109266736A (zh) * | 2018-10-18 | 2019-01-25 | 中国医学科学院北京协和医院 | 用于骨质疏松症早期筛查的分子标记物及其应用 |
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2015
- 2015-09-28 CN CN201510628024.6A patent/CN105112550B/zh active Active
Non-Patent Citations (3)
Title |
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Expression of Angiotensin II Receptor-1 in Human Articular Chondrocytes.;Kawakami Yet.al;《Arthritis》;20121230;摘要和第4页右栏最后一段 * |
Function and expression of ATIP and its variants in cardiomyoblast cell line H9c2;Naghmeh varghayee et.al;《Journal of the renin-angiotensin-aldosterone system》;20130404;79-91页 * |
MTUS1(mitochondrialtumorsuppressor 1);xiaofengzhou et.al;《Atlasdatabase》;20081231;第853页、856页 * |
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CN105112550A (zh) | 2015-12-02 |
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Denomination of invention: MTUSI gene serving as osterarthritis diagnosis target Effective date of registration: 20181225 Granted publication date: 20180807 Pledgee: Huaxia Bank Beijing branch Wanliu Limited by Share Ltd Pledgor: Beijing Yang Shen biology information technology company limited Registration number: 2018990001252 |
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Date of cancellation: 20191206 Granted publication date: 20180807 Pledgee: Huaxia Bank Beijing branch Wanliu Limited by Share Ltd Pledgor: Beijing Yang Shen biology information technology company limited Registration number: 2018990001252 |
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Effective date of registration: 20210401 Address after: 266000 room 2503, Qianshan building, D2, Qingdao International Innovation Park Phase II, No.1 Keyuan Weiyi Road, Laoshan District, Qingdao City, Shandong Province Patentee after: Qingdao Yangshen biomedical Co.,Ltd. Address before: 100080 room 3103, cube court building, 1 good luck street, Haidian District, Beijing. Patentee before: BEIJING MEDINTELL BIOMED INFORMATION TECHNOLOGY Co.,Ltd. |
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