CN105106372A - Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection - Google Patents
Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection Download PDFInfo
- Publication number
- CN105106372A CN105106372A CN201510562648.2A CN201510562648A CN105106372A CN 105106372 A CN105106372 A CN 105106372A CN 201510562648 A CN201510562648 A CN 201510562648A CN 105106372 A CN105106372 A CN 105106372A
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- folium
- ethanol
- bandage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention belongs to the field of traditional Chinese medicines, and discloses a traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection and a preparation method of the traditional Chinese medicine liquid adhesive bandage. The traditional Chinese medicine liquid adhesive bandage is prepared from the following raw materials in parts by weight: 1-8 parts of traditional Chinese medicine active ingredients, 15-35 parts of polyvinyl acetal, 10-20 parts of dibutyl phthalate, 1.5-8 parts of methylcellulose, 1.5-5 parts of hydroxypropyl methyl cellulose, 1-10 parts of glycerin, 1-5 parts of laurocapram, 55-85 parts of ethanol and 10-15 parts of diethyl ether, wherein the traditional Chinese medicine active ingredient is prepared from sensitive joint vetch leaf, common jujube spine, ramie root, peperomia pellucida, broomjutre sida herb, Indian kalimeris herb, kamuning, lycopodium clavatum and speranskia tuberculata. The traditional Chinese medicine liquid adhesive bandage has effects of clearing heat, removing toxicity, diminishing inflammation and swelling, relaxing muscles, stimulating blood circulation, dispelling wind, promoting meridians, eliminating stasis, relieving pain, removing slough, promoting growth of tissue regeneration and the like, can be used for effectively controlling bedsore wound infection and accelerating wound healing, is uniform and smooth in texture and convenient to use, has a certain elasticity after being formed into a film, does not peel skin, and cannot cause dry or tight feeling.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of decubital ulcer of preventing and treating and merge Chinese medicinal liquor bandage of bacteriological infection and preparation method thereof.
Background technology
Pressure ulcer refers to the long-term pressurized of local organization due to health, disturbance of blood circulation, continuous ischemia anoxia, and malnutrition, causes skin to lose normal function, and the tissue damage caused and necrosis.Be clinical common a kind of complication, be comparatively stubborn problem in nursery work, general incidence rate is 2.5% ~ 8.8%, even up to more than 10%.Patient, because of long-term bed, unconsciousness, circulatory disturbance, malnutrition, gatism, restraint etc., is the factor occurred frequently causing pressure ulcer.There is misery and the financial burden that not only can increase patient after pressure ulcer, but also the rehabilitation of disease can be affected, septicemia and threat to life even can occur.
Decubitus ulcer place is just as an open wound, and its exposes in atmosphere, and wound surface has more the mixed infection of aerobe, anaerobe and facultative anaerobe, great majority are staphylococcus aureuses, micrococcus scarlatinae.In recent years along with the extensive use of antibiotics, Resistant strain increases gradually, and traumatic infection is not that a kind of pathogenic bacteria causes sometimes, does not have a kind of definite method to treat at present both at home and abroad, with doctor trained in Western medicine anti symptom treatment while clinical many employing treatment protopathy.Therapeutic Method is a lot, but curative effect is different, as debridement is changed dressings, antibiotic as 0.1% furacillin solution, the external application of dilution gentamycin, hyperbaric oxygentherapy etc.Patient will bear the misery in therapeutic process, and also will frequently commute between hospital-family, Financial cost is high, causes trouble and burden to family.
The medicines such as moist expose burn ointment, SHENGFU GAO, HUATUO GAO, YUNNAN BAIYAO are to a certain extent to the slight illness alleviating patient, and accelerating wound healing, has certain therapeutical effect.But for the chronic wound treatment less effective of long-term disunion.Traditional Chinese Medicine Anti bacteriological infection mechanism is special, not easily produces drug resistance, and therefore, antibacterial Chinese medicine progressively becomes research emphasis.
Summary of the invention
The object of the invention is to, a kind of decubital ulcer of preventing and treating is provided to merge Chinese medicinal liquor bandage of bacteriological infection and preparation method thereof, obtained bandage effectively can control bedsore wound and infects and accelerate wound repair, accelerates wound healing, solves decubital ulcer and merges the cureless problem of bacteriological infection.The homogeneous exquisiteness of this Chinese medicinal liquor bandage, use not by the restriction at wound size, shape, position, place, film forming has certain elasticity, not tearing skin, without dry tight sense.
In order to realize above-mentioned purpose of the present invention, spy by the following technical solutions:
A kind of Chinese medicinal liquor bandage prevented and treated decubital ulcer and merge bacteriological infection, be prepared from primarily of following raw material, by weight, active ingredient of Chinese herbs 1-8 part, Pioloform, polyvinyl acetal 15-35 part, dibutyl phthalate 10-20 part, methylcellulose 1.5-8 part, hydroxypropyl emthylcellulose 1.5-5 part, glycerol 1-10 part, laurocapram 1-5 part, ethanol 55-85 part, ether 10-15 part;
Described active ingredient of Chinese herbs is processed by following crude drug and is prepared from: Folium Aeschynomenes indicae, Spina jujubae, Radix Boehmeriae, Herba Peperomiae pellucidae, Herba Sidae Rhombifoliae, Herba Kalimeridis, Folium Et Cacumen Murrayae, Herba Lycopodii, Herba speranskiae tuberculatae.
In order to increase the chemiluminescence of effective active composition, to reach better therapeutic effect, preferably, described active ingredient of Chinese herbs is processed by the crude drug of following weight parts and is prepared from: Folium Aeschynomenes indicae 11-16 part, Spina jujubae 5-8 part, Radix Boehmeriae 8-13 part, Herba Peperomiae pellucidae 12-17 part, Herba Sidae Rhombifoliae 15-20 part, Herba Kalimeridis 25-30 part, Folium Et Cacumen Murrayae 9-15 part, Herba Lycopodii 8-13 part, Herba speranskiae tuberculatae 12-17 part.
Further preferably, described active ingredient of Chinese herbs is processed by the crude drug of following weight parts and is prepared from: Folium Aeschynomenes indicae 15 parts, Spina jujubae 5 parts, Radix Boehmeriae 10 parts, Herba Peperomiae pellucidae 15 parts, Herba Sidae Rhombifoliae 17 parts, Herba Kalimeridis 30 parts, Folium Et Cacumen Murrayae 12 parts, Herba Lycopodii 10 parts, Herba speranskiae tuberculatae 13 parts.
Said components combines by inventor, medicine is assisted a ruler in governing a country mutually, there is heat-clearing and toxic substances removing, anti-inflammation detumescence, relaxing muscles and tendons to promote blood circulation, dispel the wind stimulate the menstrual flow, the effect such as eliminating stasis to stop pain, putrefaction-removing granulation-promoting, Fang Zhong: Herba Kalimeridis is apt to heat-clearing and toxic substances removing, cooling blood for hemostasis, inducing diuresis and reducing edema, wants product for heat-clearing and toxic substances removing.Folium Aeschynomenes indicae is sweet cold, kind removing toxic substances and promoting subsidence of swelling; Spina jujubae is pungent cold, kind heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Herba Peperomiae pellucidae has the merit of eliminating stasis to stop pain, heat-clearing and toxic substances removing, and the merit of the strong monarch drug heat-clearing and toxic substances removing of three medicines 5, dissipating blood stasis for subsidence of swelling pain relieving is ministerial drug.Herba Sidae Rhombifoliae clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling; Radix Boehmeriae is sweet cold, cooling blood for hemostasis, heat-clearing and toxic substances removing; The arduous temperature of Folium Et Cacumen Murrayae, kind promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, expelling pathogenic wind and restoring the functions of orifices in face, Herba Lycopodii toil temperature, energy expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral; Herba speranskiae tuberculatae energy expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation, dissipating blood stasis for subsidence of swelling, removing toxic substances pain relieving, five medicine compatibilities use, the merit of the heat-clearing and toxic substances removing of monarch drug ministerial drug, anti-inflammation detumescence, putrefaction-removing granulation-promoting can be strengthened, again can relaxing muscles and tendons to promote blood circulation, dispel the wind stimulate the menstrual flow, eliminating stasis to stop pain.Prescription links closely the above-mentioned method for the treatment of rule for the treatment of, thus effectively can control bedsore wound and infect and accelerate wound repair.
In order to increase the chemiluminescence between each raw material, the Chinese medicinal liquor bandage obtained reaches better effect, as homogeneous exquisiteness, easily coating after launching, tack is strong, holdup time is long, be easy to absorb, good stability, be easy to throw off, preferably, a kind of Chinese medicinal liquor bandage prevented and treated decubital ulcer and merge bacteriological infection, be prepared from primarily of following raw material, by weight, active ingredient of Chinese herbs 3-6 part, Pioloform, polyvinyl acetal 20-30 part, dibutyl phthalate 13-18 part, methylcellulose 3-6 part, hydroxypropyl emthylcellulose 2-3 part, glycerol 5-8 part, laurocapram 3-5 part, ethanol 65-80 part, ether 10-15 part.
More preferably, a kind of Chinese medicinal liquor bandage prevented and treated decubital ulcer and merge bacteriological infection, be prepared from primarily of following raw material, by weight, active ingredient of Chinese herbs 5 parts, Pioloform, polyvinyl acetal 25 parts, dibutyl phthalate 14 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 4.5 parts, ethanol 75 parts, ether 12 parts.
Medical material meridian distribution of property and flavor used is as follows:
Folium Aeschynomenes indicae: [nature and flavor] are sweet; Cold.[return through] Liver Channel.[function cures mainly] detoxifies, detumescence, hemostasis.Main carbuncle skin infection, wound hemorrhage, venom.
Spina jujubae: [nature and flavor] are pungent; Cold.[return through] heart; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Reducing swelling and alleviating pain.Main carbuncle; Sore throat; Hematuria; Stomachache; Lumbago." prescriptions worth thousand gold ": control the mistake of swelling of all evils and controlled pus: burn Spina jujubae and make ash, water takes it, goes out through lodging for the night.
Radix Boehmeriae: [nature and flavor] are sweet; Cold in nature; [return through] liver; The heart; Urinary bladder channel.[function cures mainly] cooling blood for hemostasis; Clearing heat and preventing abortion; Diuresis; Removing toxic substances.Spitting of blood caused by main bleeding due to blood-heat; Spit blood; Epistaxis; Stranguria with blood; Have blood in stool; Metrorrhagia; Purpura; Frequent fetal movement; Vaginal bleeding during pregnancy hematochezia; Dribbling urination; Carbuncle pyogenic infections from tumour or sore; Worm venom." detailed outline is picked up any lost article from the road ": " control all poison, invigorate blood circulation, hemostasis, function is dispersed, and quenches the thirst, antiabortive; Be coated with infantile erysipelas, logical distention of the abdomen caused by various parasites, metrorrhagia, nebulousurine, spermatorrhea, toothache, inflammation of the throat, bone is choked, hernia, erysipelas, and furuncle poison, wasp, poisonous snake sting, carbuncle on the back, furuncle, injury from falling down."
Herba Peperomiae pellucidae: [nature and flavor] are pungent; Cool.[return through] liver; Lung meridian.[function cures mainly] eliminating stasis to stop pain; Heat-clearing and toxic substances removing.Main carbuncle sore tumefacting virus; Burn and scald; Traumatic injury; Traumatic hemorrhage.
Herba Sidae Rhombifoliae: [nature and flavor] sweet in the mouth; Pungent; Cool.[return through] heart; Liver; Lung; Large intestine; Small intestine meridian.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.The high heat of main flu; Laryngopharynx swelling and pain; Damp-heat dysentery; Jaundice; Leukorrhagia; Stranguria; Rheumatism flaccidity is weak; Dizzy; Labor volume is weak; Hemorrhoidal bleeding; Carbuncle furuncle.
Herba Kalimeridis: [nature and flavor] acrid in the mouth; Cool in nature.[return through] returns lung; Liver; Stomach; Large intestine channel.[function cures mainly] cooling blood for hemostasis; Clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main haematemesis; Epistaxis; Dysentery; Metrorrhagia; Wound hemorrhage; Jaundice; Edema; Stranguria with turbid discharge; Flu; Cough; Pharyngalgia sore throat; Hemorrhoid; Carbuncle; Erysipelas; Infantile malnutrition." book on Chinese herbal medicine justice ": Herba Kalimeridis, most relieving heat toxin, specially can enter blood system, hemostasis removing heat from blood, especially speciality.All warm heresies, deeply battalion point, and carbuncle and ulcer heat in blood, the cards such as decomposed, permit for special medicine.Orally taken and externally, it is with very wide, also heat-clearing and toxic substances removing want product also.
Folium Et Cacumen Murrayae: [nature and flavor] pungent, micro-hardship, temperature; Slightly poisonous.[function cures mainly] promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.For stomachache, rheumatic arthralgia; External treatment is had a toothache, tumbling and swelling, worm venom." the SHENGCAO property of medicine is standby to be wanted ": " sensible, can stop skin ulcer and itch, peeling wind, kills Ci scabies for pain relieving, detumescence poison."
Herba Lycopodii: [nature and flavor] micro-hardship, pungent, temperature.[return through] returns liver,spleen,kidney warp.[function cures mainly] expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Herba speranskiae tuberculatae: [nature and flavor] are pungent; Warm in nature.[return through] lung; Liver Channel.[function cures mainly] expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Dissipating blood stasis for subsidence of swelling; Removing toxic substances pain relieving.Main air pain of dampness syndrome; Muscles and bones contracture; The disturbance of lower legs due to pathogenic cold and dampness; Lumbar strain; Paralysis; Amenorrhea; Eczema scrotum; Furuncle toxic swelling.
Another object of the present invention is to provide a kind of preparation method of preventing and treating decubital ulcer and merging the Chinese medicinal liquor bandage of bacteriological infection, it comprises following preparation process: the ethanol (preferably the ethanol of the 95%) Herba Peperomiae pellucidae after pulverizing, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae being added 85-95% extracts secondary, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 50-60 DEG C (preferably 55 DEG C) is less than 10% (preferably less than 5%), obtains ethanol extraction concentrated solution; Folium Aeschynomenes indicae after pulverizing, Radix Boehmeriae, Herba Kalimeridis, Herba Lycopodii, Herba speranskiae tuberculatae are decocted with water secondary, collecting decoction together with Herba Peperomiae pellucidae, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Spina jujubae is calcined, is ground into polarity powder; Pioloform, polyvinyl acetal, methylcellulose, ethanol are heated while stirring in 40-50 DEG C of water bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and hydroxypropyl emthylcellulose, mix and blend obtains film liquid; In 25 DEG C with following agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and the Spina jujubae calcining powder with ether dilution wherein, namely obtains product after mix homogeneously.
Applicant has carried out many-sided experiment to the effectiveness of prepared Chinese medicinal liquor bandage and safety, comprising the test of resistance bacterium, zoopery and human experimentation, result shows, this Chinese medicinal liquor bandage can merge bacteriological infection for preventing and treating decubital ulcer fast, effectively and safely.
(1) the resistance bacterium test of Chinese medicinal liquor bandage of the present invention:
In super-clean bench, draw-80 DEG C of serratia marcescens preserved, be transferred in the test tube that 10ml nutrient broth medium is housed, be placed in 37 DEG C, the shaking table 10-12h of 220 turns/min; By the nutrient broth medium (pH=7.2) after sterilizing while hot (50 DEG C) pour in culture dish, after it solidifies be inverted, with water vapor flow backwards, altogether fall 6 flat boards; The film that placement ordinary filter paper on each flat board, the filter membrane of 0.22 μm and a Chinese medicinal liquor bandage are made, corresponds to negative control film, positive control film and sample film respectively; 10 μ L bacterium liquid are dripped to the center of often opening film on flat board, with sealed membrane, the uncovered of flat board is sealed up, be placed in 28 DEG C of incubator 24h, then with liquid-transfering gun, the bacterium liquid of flat board is absorbed, with aseptic nipper, sealed membrane is taken off from culture dish, then put into 28 DEG C of incubator 24h.
Check whether the culture dish under three films coverings has bacterial growth, concrete outcome is: after cultivating 24h, and under control film, bacterial growth is good, without bacterial growth under sample film, show that Chinese medicinal liquor bandage can stop that antibacterial invades wound.Antibacterial under positive control film may be because antibacterial is moist and can become hypopus under being unfavorable for the environment of volunteer growth, thus through the filter membrane of 0.22 μm.
(2) the acute dermal toxicity test of liquid bandage of the present invention
Tested material: liquid bandage prepared by the embodiment of the present invention 1.Laboratory animal: SD rat 20, male and female half and half, body weight 200 ± 20g.
Test method: test first 24 hours, in back part of animal spinal column both sides unhairing, unhairing scope is about body surface area 10%.By 5000mg/kg body weight dose, examination Mus unhairing position is applied, after 24 hours, the residual tested material of removing, Continuous Observation 7 days.
Result of the test: have no examination Mus whole body ANOMALOUS VARIATIONS in the observation period, also have no dead, is coated with the reactions such as tested material local has no red and swollen, festers, inflammation, necrosis.These results suggest that this medicine is to the nontoxic level in the true border of rat acute percutaneous toxicity.
(3) the repeatedly Skin Irritation Test of liquid bandage of the present invention
Perform according to following State Food and Drug Administration's " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline " 2005.
Liquid bandage prepared by tested material: embodiment of the present invention 1-8.Laboratory animal: Japanese white big ear rabbit 12, male and female half and half, body weight 2.5-3.0kg.
Test method: test first 24 hours, in every rabbit back spinal column both sides cropping preserved skin, each 3cm × 6cm of unhairing scope.Get liquid bandage prepared by embodiment of the present invention 1-8 to be coated on the skin of every rabbit side, smear every day once, offside all makes solvent control.Smear 14d continuously.Cropping before being coated with every day, must not injured skin, ensures that tested material fully contacts with skin.Observe dermoreaction and marking every day.Off-test, gets and smears area skin and carry out histopathologic examination.
Experimental result: repeatedly Skin Irritation Test shows that repeatedly the highest stimulation index of skin irritation and pathological tissue integration are 0 in the present invention, according to skin irritation strength grading standard in State Food and Drug Administration's " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline ", the present invention repeatedly skin irritation intensity belongs to nonirritant.
(4) skin anaphylactic test of liquid bandage of the present invention
Perform according to following State Food and Drug Administration's " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline " 2005.
Liquid bandage prepared by tested material: embodiment of the present invention 1-3.Positive control: DNFB.Laboratory animal: provide Cavia porcellus 50 by Shandong University's medical college Experimental Animal Center, male and female half and half, body weight 250-300g.
Test method: test Cavia porcellus is divided into 5 groups at random, often organize 10, male and female half and half, are respectively tested material 1-3 group, negative control group and positive controls.
Sensitization contact: removed by guinea pig back left of spine hair for first 24 hours to tested material, unhairing scope is about 3cm × 3cm.Get tested material and be coated in district of losing hair or feathers on the left of back part of animal, continue 6 hours.7th day and fortnight, repeat once with same method, and positive controls is coated with 1%DNCB, and negative control group does not deal with.Excite contact: fortnight after last is to tested material, tested material is coated on district of losing hair or feathers on the right side of guinea pig back, after 6 hours, removes tested material, at once observe anaphylaxis situation, then again observed in 1,24,48,72 hour.Positive controls is coated with 1%DNCB, and negative control group does not deal with.Observational technique is with tested material group.
Result of the test: skin anaphylactic test shows liquid bandage of the present invention, according to according to following relevant sensitization of skin intensity evaluation standard in State Food and Drug Administration's " Chemical induced irritation, anaphylaxis and hemolytic investigative technique guideline ", the invention belongs to without sensitization.
(5) clinical observation experiment
1 data and method
1.1 diagnostic criterias: the formulation according to " People's Republic of China's traditional Chinese medicine industry standard--Chinese medical disease Standardization of diagnosis and curative effect (YZ/T001.1-94) " decubital ulcer: be apt to occur in the apophysis such as tail sacrum, ridge, elbow ankle and easily suffer oppression and the position that rubs; From the beginning of skin occurring brown erythema, micro-swollen, purple dark edema then, necrosis is festered; During secondary contamination, tissue necrosis is rapid, and pus is dripping, corresponding site Bing Fa Xing core pain; Be more common in the patient of the prolonged illness beds such as stupor, paralysis, fracture, large-area burns.
1.2 physical data: the III degree selecting my institute to accept for medical treatment in January ,-2015 in January, 2014, IV degree patients with bedsore 104 example, male 68 example, women 36 example, 55 ~ 88 years old age, average (70.5 ± 10.3) year.Decubital ulcer classification: III degree 74 example, IV degree 30 example.Symptom: infecting, having pus all appears in wounds.Site of pathological change: tail sacrum portion 54 example, hip 29 example, heel portion 14 example, other position 7 example.Be divided into treatment group and matched group to treat at random, often organize 52 examples, when entering to organize, 2 groups of cases are without significant difference (P > 0.05) in sex, age, decubital ulcer classification, have comparability.
1.3 Therapeutic Method: the equal Cure the Primary Disease of all patients, remove wound surface slough, and clean wound surface, adopts 0.5% iodophor disinfection.Matched group JINGWANHONG RUANGAO (having heat clearing away, removing heat from blood, Detoxication containing Radix Et Rhizoma Rhei, Rhizoma Coptidis, Cortex Phellodendri, Radix Sanguisorbae, Flos Lonicerae, Radix Arnebiae (Radix Lithospermi), Radix Rehmanniae, Fructus Gardeniae, Radix Arnebiae (Radix Lithospermi), Herba Lobeliae Chinensis etc.) is external application bedsore wound evenly, exposes treatment; The Chinese medicinal liquor bandage that treatment group is prepared by the embodiment of the present invention 1.2 groups of equal every days change dressings 1 time.All treat two weeks for two groups.
1.4 observation index: all cases are all observed and treated front and treatment the 3rd, 7,14 wound surface areas, and c reactive protein (, to inflammatory reaction, particularly bacterial infection inflammation and therapeutic response thereof are very responsive for CRP) chemical examination situation.
1.5 criterions of therapeutical effect: " Chinese medical disease Standardization of diagnosis and curative effect " evaluation criteria that criterion of therapeutical effect is formulated with reference to State Administration of Traditional Chinese Medicine for 1994 is evaluated: recovery from illness: wound surface all healed, without false healing phenomenons such as empyemas under crust.Effective: wound surface area reduces the scope > 75%, and without purulent secretion, granulation tissue is fresh, and color is scarlet.Effective: wound surface area reduces the scope > 25%, and obviously reduce without purulent secretion or purulent secretion, granulation tissue color is red.Invalid: wound surface area reduces the scope < 25%, wound surface purulent secretion is without obvious minimizing, and granulation tissue color is dark, and wound surface is without obviously reducing trend.Effective percentage=(recovery from illness+effective)/total number of cases × 100%.
1.6 statistical procedures application SPSS16.0 statistical softwares.Measurement data with
represent, and t inspection is adopted to data.P < 0.05 has statistical significance for difference.
2 results
After 2.1 liang of group treatments, effective percentage compares: treatment group effective percentage is 88.5%, apparently higher than 65.4% (P < 0.05) of matched group.In table 1.
Table 1: after two groups of treatments, effective percentage compares, example (%)
Compare with matched group, * P < 0.05.
After 2.2 liang of group treatments, wound surface area change compares: after result display treatment group treats the 3rd, the 7th, the 14th, wound surface area is all less than matched group (P < 0.05).In table 2.
Table 2: after two groups of treatments, wound surface area change compares (cm
2,
)
Compare with matched group, * P < 0.05.
Treatment group and CRP after treatment of control group check situation to compare: result shows treatment the 3rd, the 7th, and treatment group CRP checked situation to be all better than matched group (P < 0.05) on 1.In table 3.
Situation of checking the table 3 liang rear CRP of group treatment compares (mg/L,
)
Compare with matched group, * P < 0.05.
Clinical practice confirms, compared with JINGWANHONG RUANGAO, liquid wound of the present invention is attached to treatment decubital ulcer concurrent infection aspect and has good curative effect. effectively can lower body CRP level, reach the effect of antibacterial healing wound surface.It can form protective layer at wound surface, effectively can isolate the contact of wound surface and external environment, destroys the environment of bacterial growth, breeding; Antimicrobial component containing multiple wide spectrum, can play anti-infectious function: improve microcirculation and histanoxia simultaneously, accelerates tissue repair, thus wound healing time is shortened dramatically.
In a word, the present invention has following beneficial effect: all medicines of the present invention are assisted a ruler in governing a country mutually, there is heat-clearing and toxic substances removing, anti-inflammation detumescence, relaxing muscles and tendons to promote blood circulation, dispel the wind stimulate the menstrual flow, the effect such as eliminating stasis to stop pain, putrefaction-removing granulation-promoting, can the Growth and reproduction of effective infection control pathogen, improve microcirculation around wound surface simultaneously, increase regional flow, promote granulation tissue growth, accelerate healing.The homogeneous exquisiteness of this Chinese medicinal liquor bandage, use not by the restriction at wound size, shape, position, place, film forming has certain elasticity, not tearing skin, without dry tight sense.Good seal performance after film forming, can prevent antibacterial and foreign body from invading wound, reduce and infect.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 15 parts, Spina jujubae 5 parts, Radix Boehmeriae 10 parts, Herba Peperomiae pellucidae 15 parts, Herba Sidae Rhombifoliae 17 parts, Herba Kalimeridis 30 parts, Folium Et Cacumen Murrayae 12 parts, Herba Lycopodii 10 parts, Herba speranskiae tuberculatae 13 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 5 parts, Pioloform, polyvinyl acetal 25 parts, dibutyl phthalate 14 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 4.5 parts, ethanol 75 parts, ether 12 parts.
The preparation method of liquid bandage: the preparation method of active ingredient of Chinese herbs: the Herba Peperomiae pellucidae after pulverizing, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae are added the ethanol extraction secondary of 95%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 55 DEG C is 3.5%, obtains ethanol extraction concentrated solution; Folium Aeschynomenes indicae after pulverizing, Radix Boehmeriae, Herba Kalimeridis, Herba Lycopodii, Herba speranskiae tuberculatae are decocted with water secondary, collecting decoction together with Herba Peperomiae pellucidae, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Spina jujubae is calcined, is ground into polarity powder;
Pioloform, polyvinyl acetal, methylcellulose, ethanol are heated while stirring in 45 DEG C of waters bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and hydroxypropyl emthylcellulose, mix and blend obtains film liquid; In 15 DEG C of limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and the Spina jujubae calcining powder with ether dilution wherein, namely obtains product after mix homogeneously.
Embodiment 2
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 12 parts, Spina jujubae 6 parts, Radix Boehmeriae 12 parts, Herba Peperomiae pellucidae 12 parts, Herba Sidae Rhombifoliae 17 parts, Herba Kalimeridis 25 parts, Folium Et Cacumen Murrayae 10 parts, Herba Lycopodii 9 parts, Herba speranskiae tuberculatae 15 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 3 parts, Pioloform, polyvinyl acetal 23 parts, dibutyl phthalate 15 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.0 parts, glycerol 6.5 parts, laurocapram 4.0 parts, ethanol 70 parts, ether 12 parts.
The preparation method of liquid bandage: the preparation method of active ingredient of Chinese herbs: the Herba Peperomiae pellucidae after pulverizing, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae are added the ethanol extraction secondary of 90%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 58 DEG C is 4.5%, obtains ethanol extraction concentrated solution; Folium Aeschynomenes indicae after pulverizing, Radix Boehmeriae, Herba Kalimeridis, Herba Lycopodii, Herba speranskiae tuberculatae are decocted with water secondary, collecting decoction together with Herba Peperomiae pellucidae, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Spina jujubae is calcined, is ground into polarity powder;
Pioloform, polyvinyl acetal, methylcellulose, ethanol are heated while stirring in 47 DEG C of waters bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and hydroxypropyl emthylcellulose, mix and blend obtains film liquid; In 13 DEG C of limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and the Spina jujubae calcining powder with ether dilution wherein, namely obtains product after mix homogeneously.
Embodiment 3
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 12 parts, Spina jujubae 8 parts, Radix Boehmeriae 13 parts, Herba Peperomiae pellucidae 17 parts, Herba Sidae Rhombifoliae 15 parts, Herba Kalimeridis 30 parts, Folium Et Cacumen Murrayae 15 parts, Herba Lycopodii 12 parts, Herba speranskiae tuberculatae 15 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 5 parts, Pioloform, polyvinyl acetal 26 parts, dibutyl phthalate 15 parts, methylcellulose 3.5 parts, hydroxypropyl emthylcellulose 3 parts, glycerol 7 parts, laurocapram 4.5 parts, ethanol 77 parts, ether 14 parts.
The preparation method of liquid bandage: the preparation method of active ingredient of Chinese herbs: the Herba Peperomiae pellucidae after pulverizing, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae are added the ethanol extraction secondary of 95%, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 53 DEG C is 5%, obtains ethanol extraction concentrated solution; Folium Aeschynomenes indicae after pulverizing, Radix Boehmeriae, Herba Kalimeridis, Herba Lycopodii, Herba speranskiae tuberculatae are decocted with water secondary, collecting decoction together with Herba Peperomiae pellucidae, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Spina jujubae is calcined, is ground into polarity powder;
Pioloform, polyvinyl acetal, methylcellulose, ethanol are heated while stirring in 43 DEG C of waters bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and hydroxypropyl emthylcellulose, mix and blend obtains film liquid; In 10 DEG C of limit agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and the Spina jujubae calcining powder with ether dilution wherein, namely obtains product after mix homogeneously.
Embodiment 4
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 16 parts, Spina jujubae 7 parts, Radix Boehmeriae 12 parts, Herba Peperomiae pellucidae 12 parts, Herba Sidae Rhombifoliae 15 parts, Herba Kalimeridis 25 parts, Folium Et Cacumen Murrayae 15 parts, Herba Lycopodii 10 parts, Herba speranskiae tuberculatae 12 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 5 parts, Pioloform, polyvinyl acetal 25 parts, dibutyl phthalate 14 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 4.5 parts, ethanol 75 parts, ether 12 parts.
The preparation method of liquid bandage: the operation with reference to embodiment 1 is carried out.
Embodiment 5
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 12 parts, Spina jujubae 6 parts, Radix Boehmeriae 10 parts, Herba Peperomiae pellucidae 15 parts, Herba Sidae Rhombifoliae 17 parts, Herba Kalimeridis 30 parts, Folium Et Cacumen Murrayae 12 parts, Herba Lycopodii 10 parts, Herba speranskiae tuberculatae 13 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 4.5 parts, Pioloform, polyvinyl acetal 20 parts, dibutyl phthalate 16 parts, methylcellulose 3.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 4.5 parts, ethanol 75 parts, ether 12 parts.
The preparation method of liquid bandage: the operation with reference to embodiment 1 is carried out.
Embodiment 6
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 13 parts, Spina jujubae 6.5 parts, Radix Boehmeriae 11 parts, Herba Peperomiae pellucidae 14 parts, Herba Sidae Rhombifoliae 17 parts, Herba Kalimeridis 28 parts, Folium Et Cacumen Murrayae 12 parts, Herba Lycopodii 11 parts, Herba speranskiae tuberculatae 13 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 5 parts, Pioloform, polyvinyl acetal 25 parts, dibutyl phthalate 14 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 4.5 parts, ethanol 75 parts, ether 12 parts.
The preparation method of liquid bandage: the operation with reference to embodiment 1 is carried out.
Embodiment 7
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 15 parts, Spina jujubae 8 parts, Radix Boehmeriae 10 parts, Herba Peperomiae pellucidae 15 parts, Herba Sidae Rhombifoliae 17 parts, Herba Kalimeridis 30 parts, Folium Et Cacumen Murrayae 12 parts, Herba Lycopodii 10 parts, Herba speranskiae tuberculatae 13 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 6 parts, Pioloform, polyvinyl acetal 20 parts, dibutyl phthalate 14 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 5 parts, ethanol 75 parts, ether 10 parts.
The preparation method of liquid bandage: the operation with reference to embodiment 3 is carried out.
Embodiment 8
Crude drug composition (weight portion) of active ingredient of Chinese herbs: Folium Aeschynomenes indicae 14 parts, Spina jujubae 6.5 parts, Radix Boehmeriae 12 parts, Herba Peperomiae pellucidae 12 parts, Herba Sidae Rhombifoliae 20 parts, Herba Kalimeridis 30 parts, Folium Et Cacumen Murrayae 14 parts, Herba Lycopodii 12 parts, Herba speranskiae tuberculatae 16 parts;
The composition (weight portion) of liquid bandage: active ingredient of Chinese herbs 5 parts, Pioloform, polyvinyl acetal 25 parts, dibutyl phthalate 14 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 4.5 parts, ethanol 75 parts, ether 12 parts.
The preparation method of liquid bandage: the operation with reference to embodiment 2 is carried out.
Claims (6)
1. the Chinese medicinal liquor bandage prevented and treated decubital ulcer and merge bacteriological infection, it is characterized in that being prepared from by following raw material, by weight, active ingredient of Chinese herbs 1-8 part, Pioloform, polyvinyl acetal 15-35 part, dibutyl phthalate 10-20 part, methylcellulose 1.5-8 part, hydroxypropyl emthylcellulose 1.5-5 part, glycerol 1-10 part, laurocapram 1-5 part, ethanol 55-85 part, ether 10-15 part;
Described active ingredient of Chinese herbs is processed by following crude drug and is prepared from: Folium Aeschynomenes indicae, Spina jujubae, Radix Boehmeriae, Herba Peperomiae pellucidae, Herba Sidae Rhombifoliae, Herba Kalimeridis, Folium Et Cacumen Murrayae, Herba Lycopodii, Herba speranskiae tuberculatae.
2. Chinese medicinal liquor bandage as claimed in claim 1, is characterized in that described active ingredient of Chinese herbs is processed by following raw material medicine and is prepared from: Folium Aeschynomenes indicae 11-16 part, Spina jujubae 5-8 part, Radix Boehmeriae 8-13 part, Herba Peperomiae pellucidae 12-17 part, Herba Sidae Rhombifoliae 15-20 part, Herba Kalimeridis 25-30 part, Folium Et Cacumen Murrayae 9-15 part, Herba Lycopodii 8-13 part, Herba speranskiae tuberculatae 12-17 part.
3. Chinese medicinal liquor bandage as claimed in claim 2, is characterized in that described active ingredient of Chinese herbs is processed by following preferred weight part crude drug and is prepared from: Folium Aeschynomenes indicae 15 parts, Spina jujubae 5 parts, Radix Boehmeriae 10 parts, Herba Peperomiae pellucidae 15 parts, Herba Sidae Rhombifoliae 17 parts, Herba Kalimeridis 30 parts, Folium Et Cacumen Murrayae 12 parts, Herba Lycopodii 10 parts, Herba speranskiae tuberculatae 13 parts.
4. the Chinese medicinal liquor bandage as described in claim 1-3, it is characterized in that being prepared from by following raw material, by weight, active ingredient of Chinese herbs 3-6 part, Pioloform, polyvinyl acetal 20-30 part, dibutyl phthalate 13-18 part, methylcellulose 3-6 part, hydroxypropyl emthylcellulose 2-3 part, glycerol 5-8 part, laurocapram 3-5 part, ethanol 65-80 part, ether 10-15 part.
5. Chinese medicinal liquor bandage as claimed in claim 4, it is characterized in that being prepared from by following raw material, by weight, active ingredient of Chinese herbs 5 parts, Pioloform, polyvinyl acetal 25 parts, dibutyl phthalate 14 parts, methylcellulose 4.5 parts, hydroxypropyl emthylcellulose 2.5 parts, glycerol 6 parts, laurocapram 4.5 parts, ethanol 75 parts, ether 12 parts.
6. the Chinese medicinal liquor bandage as described in claim 1-5, it is characterized in that preparation method, it comprises following preparation process: the ethanol (preferably the ethanol of the 95%) Herba Peperomiae pellucidae after pulverizing, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae being added 85-95% extracts secondary, each 1.5-2.0 hour, collect ethanol extraction filtering residue, merge extractive liquid, being evaporated to ethanol content in 50-60 DEG C (preferably 55 DEG C) is less than 10% (preferably less than 5%), obtains ethanol extraction concentrated solution; Folium Aeschynomenes indicae after pulverizing, Radix Boehmeriae, Herba Kalimeridis, Herba Lycopodii, Herba speranskiae tuberculatae are decocted with water secondary, collecting decoction together with Herba Peperomiae pellucidae, Herba Sidae Rhombifoliae, Folium Et Cacumen Murrayae ethanol extraction filtering residue, and filter, concentrating under reduced pressure becomes dry extract, pulverizes and obtains water extract dry extract; Spina jujubae is calcined, is ground into polarity powder; Pioloform, polyvinyl acetal, methylcellulose, ethanol are heated while stirring in 40-50 DEG C of water bath with thermostatic control, after material to be filmed dissolves completely, add laurocapram, glycerol, dibutyl phthalate and hydroxypropyl emthylcellulose, mix and blend obtains film liquid; In 25 DEG C with following agitated-film liquid, limit adds ethanol extraction concentrated solution, water extract dry extract and the Spina jujubae calcining powder with ether dilution wherein, namely obtains product after mix homogeneously.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510562648.2A CN105106372A (en) | 2015-09-07 | 2015-09-07 | Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510562648.2A CN105106372A (en) | 2015-09-07 | 2015-09-07 | Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105106372A true CN105106372A (en) | 2015-12-02 |
Family
ID=54654650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510562648.2A Pending CN105106372A (en) | 2015-09-07 | 2015-09-07 | Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105106372A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381502A (en) * | 2015-12-21 | 2016-03-09 | 杨雁 | Larva chrysomyiae liquid wound dressing and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
| CN104814982A (en) * | 2015-04-21 | 2015-08-05 | 华侨大学 | Traditional Chinese medicine liquid adhesive bandage and preparation method |
-
2015
- 2015-09-07 CN CN201510562648.2A patent/CN105106372A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101920042A (en) * | 2010-07-16 | 2010-12-22 | 四川理工学院 | Liquid bandage and preparation method |
| CN104814982A (en) * | 2015-04-21 | 2015-08-05 | 华侨大学 | Traditional Chinese medicine liquid adhesive bandage and preparation method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381502A (en) * | 2015-12-21 | 2016-03-09 | 杨雁 | Larva chrysomyiae liquid wound dressing and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103721131B (en) | A kind of Chinese medicine suppository and its preparation method treating women's chronic pelvic inflammatory disease | |
| CN102178877B (en) | External preparation for treating eczema of scrotum and preparation method thereof | |
| CN105770239A (en) | External health gel for treating gynecological inflammation | |
| CN113616714A (en) | High-selenium anti-HPV (human papillomavirus) biological protein gel dressing and preparation method thereof | |
| CN103520439B (en) | Traditional Chinese medicine for treating heat-toxicity accumulation type chronic osteomyelitis and preparation method thereof | |
| CN104906465A (en) | Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof | |
| CN105106372A (en) | Traditional Chinese medicine liquid adhesive bandage for preventing and treating bedsore with bacterial infection | |
| CN101708222B (en) | Chinese medicinal unguent for treating bedsore and preparation method thereof | |
| CN105079332A (en) | Traditional Chinese medicine composition for treating perianal abscess caused by fire toxin accumulation | |
| CN105106459A (en) | Traditional Chinese medicine gelling agent for treating superficial ulcer stage pressure sores and preparation method thereof | |
| CN104958613B (en) | Chinese medicine composition of malicious decomposed type decubital ulcer and preparation method thereof is accumulate in a kind for the treatment of | |
| CN105168625B (en) | A kind of clinical care is used for the treatment of the Chinese medicine liniment of two, three phase decubital ulcers | |
| CN103301234A (en) | Traditional Chinese medicine composition for treating wound healing and preparation method thereof | |
| CN105079482B (en) | A kind of Chinese medicine external gel treating the companion's infection of serious decubital ulcer and preparation method thereof | |
| CN101057921B (en) | Traditional Chinese medicine capsule for treating prostatic hyperplasia | |
| CN105169128A (en) | Traditional Chinese medicine spraying film agent for treating bacterial bedsore and preparation method thereof | |
| CN105797095A (en) | Traditional Chinese medicine external lotion for preventing and treating calf varicosity | |
| CN105362516A (en) | Tincture for treating plasmacellular mastitis and preparation method thereof | |
| CN105381366A (en) | Traditional Chinese medicine composition for treating bedsores and preparing method thereof | |
| CN105055622B (en) | A kind of Chinese medicine film-forming gel agent treating either shallow bed sore at ulcerative stage | |
| CN105168638A (en) | Traditional Chinese medicinal liquid band aid for preventing and treating bedsore complicated with bacterial infection | |
| CN105878581A (en) | Liquid traditional Chinese medicine for treating verruca plana and preparation method thereof | |
| CN104491104A (en) | Traditional Chinese medicine composition for treating bedsore in clinical care | |
| CN104971323B (en) | Vaginal care cream and preparation method thereof | |
| CN104524225A (en) | Traditional Chinese medicine for treating kidney-deficiency type belly postoperative urinary retention |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151202 |
|
| RJ01 | Rejection of invention patent application after publication |