CN105106093B - A kind of face rejuvenation cosmetic formulation and preparation method thereof - Google Patents
A kind of face rejuvenation cosmetic formulation and preparation method thereof Download PDFInfo
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- CN105106093B CN105106093B CN201510581944.7A CN201510581944A CN105106093B CN 105106093 B CN105106093 B CN 105106093B CN 201510581944 A CN201510581944 A CN 201510581944A CN 105106093 B CN105106093 B CN 105106093B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/983—Blood, e.g. plasma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The present invention relates to beautifying technique fields, disclose a kind of face rejuvenation cosmetic formulation and preparation method thereof.Face rejuvenation cosmetic formulation of the present invention includes hyaluronic acid, human stem cell growth and rich in hematoblastic high-concentration blood plasma.Present invention adjustment pharmaceutical formulation is human stem cell growth, hyaluronic acid and rich in hematoblastic high-concentration blood plasma, is significantly improved relative to existing cosmetic formulation making skin smooth, flexible, in terms of anti-aging effect.
Description
Technical field
The present invention relates to beautifying technique fields, particularly relate to a kind of face rejuvenation cosmetic formulation and its preparation side
Method.
Background technology
Facial aging, be body knead dough, neck soft, sclerous tissues change jointly as a result, aging face and constitution, heredity
The factors such as factor, living environment, mental emotion, job specification, nutrition condition, disease, topical skin care have close pass
Connection.Common people just start aging sign occur, the formation of face skin wrinkle is an important feature and refers to after 25 years old
Mark.
Face rejuvenation is the facial various means for restoring rejuvenation appearance and method for referring to make aging (including outer
Shape, dissection and physiological structure etc.).With the improvement of living standards, requirement of the people to makings shape is higher and higher, it is beautiful pursuing
While safety is also had higher requirement, water optoinjection technology is minimally invasive, painless, restore fast, and effect is good, receives
The favor of people seeking beauty.
Water optoinjection technology is under the control of micro computer, is inhaled skin by negative pressure system using special injection tool
It rises, preparation is imported into the space of negative pressure a kind of therapy at corresponding position.Water optoinjection master system to be used at present
Agent prescription for folk prescription hyaluronic acid (HA) or hyaluronic acid (HA)+rich in hematoblastic high-concentration blood plasma (PRP) and thoroughly
Bright matter sour (HA)+and rich in growth factor blood plasma (PRGF), such as patent CN200880101622.
Hyaluronic acid (HA) is the one of which composition of human body skin corium, has the ability for keeping moisture content, and deal is more up to
100 times or more of itself weight, human skin surface layer (cuticula) moisture account for about 15-30%, and hyaluronic acid acts on
It inside skin after conditioning, can automatically adjust in different environments, moisture of skin is maintained to keep the wet of skin in 25-30% always
It is profit, salubrious, make skin more high resilience, play the role of it is crease-resistant it is wrinkle resistant, delay the full skin aging of people, beautifying face and moistering lotion.
It is the product from autologous platelet after purification concentrates rich in hematoblastic high-concentration blood plasma (PRP).PRP is
It is widely used in every field, and extends to the application of face rejuvenation.Releasable a series of Porcine HGF, such as
VEGF, platelet derived growth factor (PDGF), IGF, TGF, these factors, which have all been confirmed in experiment, to be had control cell migration, sticks
Attached, proliferation, and help, by being combined with cell surface receptor, to improve the release of extracellular matrix protein.To smoothing wrinkle, desalination
Scar color spot has remarkable efficacy.And the blood plasma (PRGF) rich in growth factor belongs to one kind in PRP, contains moderate quatity blood
Platelet does not contain leucocyte, it is activated by addition calcium chloride, so as to discharge various reparative factors.
Although above-mentioned cosmetic formulation can make the effect that more smooth skin of face, wrinkle desalination, anti-aging etc. are in rejuvenation,
But effect is still not apparent enough.
Invention content
In view of this, the purpose of the present invention is to provide a kind of face rejuvenation cosmetic formulations and preparation method thereof so that
The face rejuvenation cosmetic formulation can be obviously improved the effect of skin rejuvenation.
To achieve these goals, the present invention provides following technical solution：
A kind of face rejuvenation cosmetic formulation, including hyaluronic acid, human stem cell growth and rich in hematoblastic
High-concentration blood plasma.
Human stem cell growth (human Stem Cell Growth Factor, hSCGF) is one kind in marrow hemopoiesis
The early stage hematopoiesis stimulating factors to work in microenvironment.There are two types of form, full-length molecule hSCGF- α (human Stem for its tool
Cell Growth Factor- α, hSCGF- α) and the Ca that is guarded in C-terminal2+Rely on 78 amino acid of missing in sugar identification structural domain
Truncated-type molecule hSCGF- β.Human stem cell growth has various biological activity, is distributed mainly on brain, liver, bone
Marrow, placenta, testis, kidney etc. are thin by stroma cell, fibroblast, endothelial cell, the ovum in these tissues (especially marrow)
Born of the same parents, sertoli cell, liver cell generate.Research confirms, SCGF has in the agglutination of wound significantly in the injury repair of various tissues
Effect, SCGF can promote angiogenesis, wound healing.SCGF can by act on skin corium into fiber stem cell, make place
Break up a large amount of fibroblast in dormancy, the simultaneously maturation that is activated and repairs into fiber stem cell of damage.The acquisition of hSCGF can
It synthesizes to obtain by this field genetic engineering means, specific method is referring to document《The clone of human stem cell growth-α genes,
Express and its cooperate with proliferation functions of the rhGM-CSF to human umbilical cord mesenchymal stem cells》(Peng Xinlei etc., 2011, biotechnology
Report).
The defects of preparation to be used for existing water optoinjection master of the invention, adjustment pharmaceutical formulation are that human stem cell is given birth to
The long factor, hyaluronic acid and rich in hematoblastic high-concentration blood plasma, face rejuvenation is realized by the synergistic effect of three
Effect.
Wherein, preferably, described obtained rich in hematoblastic high-concentration blood plasma by following preparation method：
The centrifugation of body whole blood is derived from, blood plasma is taken, abandons red blood cell, centrifuge again, retains 30-60% blood plasma, remainder abandons, with guarantor
Precipitation is resuspended in the blood plasma stayed, and gained is rich in hematoblastic high-concentration blood plasma.
It is highly preferred that described obtained rich in hematoblastic high-concentration blood plasma by following preparation method：
Body whole blood is derived from 150-400g centrifugal force 5-10min, is taken blood plasma, is abandoned red blood cell, 400-1200g centrifugations 5-
10min retains 30-60% blood plasma, and remainder abandons, and precipitation is resuspended with the blood plasma of reservation, gained is rich in hematoblastic highly concentrated
Spend blood plasma.
Preferably, a concentration of 2-10mg/mL of human stem cell growth, the hyaluronic acid concentration 1-5mg/mL,
Rich in hematoblastic high-concentration blood plasma 80-95% of the total volume.It is highly preferred that the human stem cell growth is a concentration of
7mg/mL, hyaluronic acid concentration 2mg/mL, rich in hematoblastic high-concentration blood plasma of the total volume 90%.
In the specific embodiment of the present invention, human stem cell growth concentration can also be in the cosmetic formulation
2mg/mL, 5mg/mL, 6mg/mL or 10mg/mL, the hyaluronic acid concentration also with for 1mg/mL, 3mg/mL, 4mg/mL or
5mg/mL, it is described rich in hematoblastic high-concentration blood plasma percent by volume can also be 80%, 85%, 87% or 95%.
Preferably, the molecular weight of the hyaluronic acid or Sodium Hyaluronate is 1 × 106-5×106。
Preferably, the human stem cell growth is hSCGF- α type human stem cell growths.
In the contrast test with existing preparation, cosmetic formulation of the present invention can be substantially reduced cutaneous roughness,
Make skin more smooth, while significantly improve skin elasticity relative change rate, promote the effect of its anti-aging, overall effect is better than existing
There is preparation.Meanwhile in the personal using effect test of volunteer, continuous January can be apparent using cosmetic formulation of the present invention
Wrinkle around wrinkles on one's forehead and canthus is reduced, skin restores smooth, elastic.The present invention provides the cosmetic formulations as a result, to go
Application in wrinkle, glabrous skin, anti aging effect.
In addition, the present invention also provides the preparation method of the cosmetic formulation, including：
Step 1 is derived from the centrifugation of body whole blood, takes blood plasma, abandons red blood cell, centrifuge again, retain 30-60% blood plasma, remainder is lost
It abandons, precipitation is resuspended with the blood plasma of reservation, obtains rich in hematoblastic high-concentration blood plasma；
Step 2, with rich in hematoblastic high-concentration blood plasma human stem cell growth dissolving mixing after, with hyaluronic acid
Abundant mixing obtains the cosmetic formulation.
By above technical scheme it is found that present invention adjustment pharmaceutical formulation is human stem cell growth, hyaluronic acid and richness
Containing hematoblastic high-concentration blood plasma, being significantly improved relative to existing cosmetic formulation makes skin smooth, flexible, anti-aging side
The effect in face.
Description of the drawings
The skin arithmetic average roughness change rate column diagram of different face rejuvenation products shown in Fig. 1；Wherein, A groups generation
Table preparation of the embodiment of the present invention, B groups represent hyaluronic acid single preparations of ephedrine, and C groups represent PRP+HA preparations, and D groups represent PRGF+HA systems
Agent；
Skin elasticity relative change rate's column diagram of different face rejuvenation products shown in Fig. 2；Wherein, A groups represent Ben Fa
Bright embodiment preparation, B groups represent hyaluronic acid single preparations of ephedrine, and C groups represent PRP+HA preparations, and D groups represent PRGF+HA preparations.
Specific embodiment
The embodiment of the invention discloses a kind of face rejuvenation cosmetic formulations and preparation method thereof.Those skilled in the art can
To use for reference present disclosure, it is suitably modified technological parameter realization.In particular, it should be pointed out that all similar substitutions and modifications are to this
It is it will be apparent that they are considered as being included in the present invention for field technology personnel.The product and preparation method of the present invention
Be described by preferred embodiment, related personnel significantly can not depart from the content of present invention, in spirit and scope it is right
Product as described herein and method are modified or suitably changed with combining, to realize and using the technology of the present invention.
For a further understanding of the present invention, with reference to embodiment to a kind of face rejuvenation beauty system provided by the invention
Agent and preparation method thereof is described in detail.
Embodiment 1：The preparation of face rejuvenation cosmetic formulation of the present invention
The self whole bloods of 10-50ml is taken to centrifuge 5-10min under 150-400g centrifugal force, take blood plasma, abandon red blood cell, 400-
1200g centrifuges 5-10min, retains 30-60% blood plasma, and remainder abandons, and precipitation is resuspended with the blood plasma of reservation, gained is PRP.With
PRP, with the abundant mixing of 0.5ml 20mg/ml hyaluronic acids, is placed in injection after the dissolving mixing of 35mg human stem cell growths
In device, human stem cell growth a concentration of 7mg/mL, hyaluronic acid concentration 2mg/mL described in the cosmetic formulation that is obtained are rich
Containing hematoblastic high-concentration blood plasma of the total volume 90%.
Dosage：0.01mL/cm2-0.02mL/cm2。
Embodiment 2：The preparation of face rejuvenation cosmetic formulation of the present invention
The preparation method is the same as that of Example 1, a concentration of 10mg/mL of human stem cell growth described in the cosmetic formulation obtained,
Hyaluronic acid concentration is 1mg/mL, rich in hematoblastic high-concentration blood plasma of the total volume 95%.
Dosage：0.01mL/cm2-0.02mL/cm2。
Embodiment 3：The preparation of face rejuvenation cosmetic formulation of the present invention
The preparation method is the same as that of Example 1, a concentration of 5mg/mL of human stem cell growth described in the cosmetic formulation obtained, thoroughly
Bright matter acid concentration is 4mg/mL, rich in hematoblastic high-concentration blood plasma of the total volume 85%.
Dosage：0.01mL/cm2-0.02mL/cm2。
Embodiment 4：The preparation of face rejuvenation cosmetic formulation of the present invention
The preparation method is the same as that of Example 1, a concentration of 2mg/mL of human stem cell growth described in the cosmetic formulation obtained, thoroughly
Bright matter acid concentration is 5mg/mL, rich in hematoblastic high-concentration blood plasma of the total volume 80%.
Dosage：0.01mL/cm2-0.02mL/cm2。
Embodiment 5：The preparation of face rejuvenation cosmetic formulation of the present invention
The preparation method is the same as that of Example 1, a concentration of 6mg/mL of human stem cell growth described in the cosmetic formulation obtained, thoroughly
Bright matter acid concentration is 3mg/mL, rich in hematoblastic high-concentration blood plasma of the total volume 87%.
Dosage：0.01mL/cm2-0.02mL/cm2。
Embodiment 6：Skin test contrast test
80 Chinese women subjects are recruited, age 30-60 Sui, are divided into four groups, every group of 20 people use the flat of A group preparations
Equal age (41.02 ± 1.93) year.Using average age (40.64 ± 2.01) year of B group preparations, being averaged for C group preparations is used
Year at age (40.71 ± 1.78), with average age (40.97 ± 1.54) year of D group preparations.Every subject is apprised of entirely
Research process, and sign informed consent form.It is continuous to see to four groups of subject's faces by water optoinjection technology using preparation 5ml
It examines 28 days, during which without using other skin-protection products, normal activity pays attention to sun-proof.
A group preparations：1 preparation of embodiment；
B group preparations：5mL 20mg/ml hyaluronic acids commercial goods；
C group preparations：PRP+HA；The self whole blood 400g centrifugations 5min of 20mL, take blood plasma, abandon red blood cell, 1200g centrifugations
5min retains 5mL blood plasma, and remainder abandons, and precipitation is resuspended, gained is PRP.In super-clean bench, the PRP of acquisition is passed through into threeway
The 20mg/mL hyaluronic acid mixings of pipe and 0.5ml, are placed in syringe；
D group preparations：PRGF+HA；The self whole blood 400g centrifugations 5min of 20ml, take blood plasma, abandon red blood cell, 1200g centrifugations
5min retains 5mL blood plasma, and remainder abandons, and precipitation is resuspended, gained is PRP.The calcium chloride of 10mM is added in PRP, treats blood clotting
After block is fully shunk, 400g centrifugation 5min draw whole supernatants, as PRGF.In super-clean bench, the PRGF of acquisition is passed through
The 20mg/mL hyaluronic acid mixings of three-way pipe and 0.5mL, are placed in syringe.
It is more using skin elasticity tester and MicroSkinII by tester before subject uses and after using 28 days
Function skin lens image analysis system measures the elasticity and dermatoglyph using position.Every is surveyed 5 times, is averaged, before test
Test position is cleaned with clear water.Statistics uses the skin of face situation of change after preparation, wherein arithmetic average roughness change rate
The arithmetic mean roughness * 100% of=(the 28th day arithmetic mean roughness arithmetic mean roughness of-the first day)/first day；
Elastic relative change rate=(tested region elasticity-blank control region elasticity)/blank control region elasticity, the result is shown in Figure 1 and
Fig. 2.
As shown in Figure 1, A groups skin roughness reduces maximum, represents that skin roughness improves degree highest, and present invention effect
Fruit is better than B, C, D group, as a result with the significance of difference (P<0.01).
Elastic relative change rate is bigger, illustrates that the anti-aging effects of preparation are more apparent, skin is flexible.As shown in Figure 2, originally
Invention A group Flexible change rates are significantly higher than B, C, D group (P<0.01).
According to the method described above, 2-5 of embodiment of the present invention preparations are carried out to identical contrast test, the results show that of the invention
Embodiment 2-5 Formulation Skins roughness reduces maximum, and Flexible change rate highest is significantly better than tri- groups of BCD.
The explanation of above example is only intended to facilitate the understanding of the method and its core concept of the invention.It should be pointed out that pair
For those skilled in the art, without departing from the principle of the present invention, the present invention can also be carried out
Some improvements and modifications, these improvement and modification are also fallen within the protection scope of the claims of the present invention.
Claims (8)
1. a kind of face rejuvenation cosmetic formulation, which is characterized in that by hyaluronic acid, human stem cell growth and rich in blood
The high-concentration blood plasma composition of platelet, a concentration of 2-10mg/mL of human stem cell growth, hyaluronic acid concentration 1-5mg/
ML, rich in hematoblastic high-concentration blood plasma 80-95% of the total volume.
2. cosmetic formulation according to claim 1, which is characterized in that described to be rich in hematoblastic high-concentration blood plasma by following system
Preparation Method obtains：
The centrifugation of body whole blood is derived from, blood plasma is taken, abandons red blood cell, centrifuge again, retains 30-60% blood plasma, remainder abandons, with reservation
Precipitation is resuspended in blood plasma, and gained is rich in hematoblastic high-concentration blood plasma.
3. cosmetic formulation according to claim 2, which is characterized in that described to be rich in hematoblastic high-concentration blood plasma by following system
Preparation Method obtains：
Body whole blood is derived from 150-400g centrifugal force 5-10min, is taken blood plasma, is abandoned red blood cell, 400-1200g centrifugations 5-
10min retains 30-60% blood plasma, and remainder abandons, and precipitation is resuspended with the blood plasma of reservation, gained is rich in hematoblastic highly concentrated
Spend blood plasma.
4. cosmetic formulation according to claim 1, which is characterized in that a concentration of 7mg/mL of human stem cell growth,
Hyaluronic acid concentration is 2mg/mL, rich in hematoblastic high-concentration blood plasma of the total volume 90%.
5. cosmetic formulation according to claim 1, which is characterized in that the molecular weight of the hyaluronic acid is 1 × 106-5×
106。
6. cosmetic formulation according to claim 1, which is characterized in that the human stem cell growth is hSCGF- α type people
Stem cell factor.
7. cosmetic formulation is gone in preparation in wrinkle, glabrous skin, anti aging effect product described in claim 1-6 any one
Application.
8. the preparation method of cosmetic formulation described in claim 1, which is characterized in that including：
Step 1 is derived from the centrifugation of body whole blood, takes blood plasma, abandons red blood cell, centrifuge again, retains 30-60% blood plasma, and remainder abandons, and uses
Precipitation is resuspended in the blood plasma of reservation, obtains rich in hematoblastic high-concentration blood plasma；
Step 2, with rich in hematoblastic high-concentration blood plasma human stem cell growth dissolving mixing after, it is abundant with hyaluronic acid
Mixing obtains the cosmetic formulation.
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| CN102008754A (en) * | 2010-12-14 | 2011-04-13 | 梁杰 | Cosmetic filler with long-term effectiveness capable of promoting soft tissue regeneration |
| CN104337835A (en) * | 2014-11-13 | 2015-02-11 | 河南金泰生物技术股份有限公司 | Preparation method for platelet rich plasma (PRP) |
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| CN104644523B (en) * | 2015-01-27 | 2018-07-03 | 广西达庆生物科技股份有限公司 | A kind of medical bio smoothing wrinkle suppression spot dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102008754A (en) * | 2010-12-14 | 2011-04-13 | 梁杰 | Cosmetic filler with long-term effectiveness capable of promoting soft tissue regeneration |
| CN104337835A (en) * | 2014-11-13 | 2015-02-11 | 河南金泰生物技术股份有限公司 | Preparation method for platelet rich plasma (PRP) |
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