CN105106027B - Hair growth promoting agents - Google Patents
Hair growth promoting agents Download PDFInfo
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- CN105106027B CN105106027B CN201510534291.7A CN201510534291A CN105106027B CN 105106027 B CN105106027 B CN 105106027B CN 201510534291 A CN201510534291 A CN 201510534291A CN 105106027 B CN105106027 B CN 105106027B
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Abstract
The present invention relates to a kind of hair growth promoting agents, the hair growth promoting agents include mainly adenine or adenine salt as active material；And cosmetics carrier, the active material accounts for 0.0001% or more of constituent weight percent, and cosmetics carrier is lubricant, solvent, moisturizer or thickener, it can be applied to the Related products such as hair lotion, clean hair-cream liquid, hair moistening liquid, hair-care gel, hair shaping liquid or shampoo, the present invention not only has the function of stimulating hair growth, prevents from shaving one's head, it may have the effect of promoting eyelash to be grown with eyebrow.
Description
It is that on November 22nd, 2010 and application are entitled that the application, which is application No. is the 201010557296.9, applying date,
The divisional application of the application of " hair growth promoting agents ".
Technical field
The present invention relates to a kind of hair growth promoting agents, espespecially one kind can maintain hair growth and increase its dense degree
Hair growth promoting agents.
Background technology
Since aging of population now and life stress are growing day by day, more and more people be faced with shave one's head or bald head
Crisis.It is pointed out according to medical research, this crisis also results in the psychology and emotional stress of family, therefore most people is attempted searching and had
The method of effect treatment alopecia.For universal, trichomadesis is the dihydro caused by dihydrotestosterone in male hormones and hair follicle
Testosterone can reduce the blood flow of hair follicle and hair corium papilla, keep scalp nutrient insufficient or generate oxidation reaction, therefore general
Hair lotion formula has the ingredient eliminated or mitigate above-mentioned symptom, for example, adding Swertia patens extract liquor, vitamin E and its derivative
Object or phatidylcholine derivative are to increase the blood circulation of scalp, or Amino acid such as serine or methionine, vitamin, such as B6 is added
Deng nourishing hair follicle with pre-Anti-hair loss, promote natural on-off cycles of hair growth.
Food and Drug Administration (FDA) proposes two kinds of ingredients for treating male bald disease, respectively Finasteride
(finasteride, United States Patent (USP) card 2006/0099251A1) and minoxidil (minoxidil, United States Patent (USP) card number
4139619)；Finasteride (finasteride) makes free testosterone be converted into dihydro-testosterone using the 5- 5 alpha-reductases of inhibitory activity
Ketone causes hair follicle imperceptibility (Dallob, 1994), is originally used for treatment benign prostate hyperplasia (BPH), but hair later
Male bald disease can also now be effectively treated；Minoxidil (minoxidil) is a kind of vasodilator, is that one kind can originally
The oral drugs (Loniten) for treating hypertension, its side effect is found at the 1980's can make natural on-off cycles of hair growth and inhibit to fall
Hair；Pu Qiang companies obtain a kind of product containing 2% minoxidil (minoxidil) of FDA approval listings, for treat alopecia and
It shaves one's head disease (Rogaine and Regaine), it is effective the reason is that since it may be led by expanding blood vessel and open potassium channel
More oxygen, blood and nutrient is caused to enter in hair follicle；Hair lotion is proposed minoxidil (minoxidil) makes together with adenosine
With (Li, 2001), and receptor pathway (Iino, 2007) is used as by A2b adenosines, thus disclose adenosine also and have treat it is bald
The function of head disease, but may will produce side effect, can especially when minoxidil (m inoxidil) is when adenosine is used together
Oedema, too fast, expiratory dyspnea aroused in interest, fatigue and nausea can be generated, and may result in the formation of cancer.
Although having attempted to use above-mentioned various methods, hair lotion on the market may not be in any area of scalp at present
Domain all has the ability for fully preventing from shaving one's head and promoting natural on-off cycles of hair growth, for example, uses that non-hero overhead or at forehead
When amine (finasteride) is with minoxidil (minoxidil), almost only the top of the head can effectively bear hair；In addition, big portion
Treatment of dividing and ruling has to pass through the long time just effective appearance of meeting, for example, 4 to 6 months；Treating alopecia also can be by transplanting hair
Hair operation solves the problems, such as, but pain can be felt in surgical procedure, and can not ensure the success that is bound to, and hair even needs to wait for number
It can just be regenerated after the moon to the several years.
Invention content
In view of this, the purpose of the present invention is to provide a kind of hair growth promoting agents.
A kind of hair growth promoting agents provided by the invention, the hair growth promoting agents include mainly：Adenine or gland
Purine salt is as active material；And cosmetics carrier.
As a kind of above-mentioned preferred embodiment of hair growth promoting agents, wherein the hair growth promoting agents pass through adenine
Or adenine salt is used in mixed way with cosmetics carrier.
As a kind of above-mentioned preferred embodiment of hair growth promoting agents, wherein the active material accounts for hair growth promoting agents
0.0001% or more of weight percent.
As a kind of above-mentioned preferred embodiment of hair growth promoting agents, wherein the cosmetics carrier be lubricant, solvent,
Or mixtures thereof moisturizer, thickener, powder.
As a kind of above-mentioned preferred embodiment of hair growth promoting agents, wherein the cosmetics carrier, is hair lotion, clean hair
Lotion, hair moistening liquid, hair-care gel, hair shaping liquid or shampoo.
A kind of eyelash provided by the invention and eyebrow growth promoter, the eyelash are formed with eyebrow growth promoter
For：Adenine or adenine salt are as active material；And cosmetics carrier.
As a kind of above-mentioned preferred embodiment of eyelash and eyebrow growth promoter, wherein the cosmetics carrier is hair tonic
Water, clean hair-cream liquid, hair moistening liquid, hair-care gel, hair shaping liquid or shampoo.
One kind provided by the invention is shaved one's head preventing agent, and the preventing agent of shaving one's head includes mainly：Adenine or adenine salt
As active material；And cosmetics carrier.
As a kind of above-mentioned preferred embodiment for preventing agent of shaving one's head, wherein the cosmetics carrier be hair lotion, clean hair-cream liquid,
Hair moistening liquid, hair-care gel, hair shaping liquid or shampoo.
The hair growth promoting agents of the present invention, are used as active material by adenine or adenine salt；And cosmetics
Carrier, it is possible to provide do not injure hair lotion, clean hair-cream liquid, hair moistening liquid, hair-care gel, the hair fixing of human skin or scalp
Liquid or shampoo not only have stimulation hair growth, prevent from shaving one's head, or even also have the work(for promoting eyelash and eyebrow growth
Effect.
Description of the drawings
Fig. 1 is the hair corium papilla cytothesis test and comparison figure of the present invention.
Specific implementation mode
In order to achieve the above objectives and effect, it is described as follows below in conjunction with drawings and examples, so that this field
Those of ordinary skill can implement the present invention according to as described below.
First, the present invention provides a kind of hair growth promoting agents, includes mainly that adenine or adenine salt are used as and live
Property substance and cosmetics carrier, the ratio regular meeting of active material is different because being formulated form, production method, accounts for ingredient
The preferred range of weight percent is 0.0001% or more, which can pass through hair lotion, clean hair-cream liquid, profit
The forms such as lotion, hair-care gel, hair shaping liquid or shampoo exist, and are applied to by liquid, paste or emulsion state
Skin or scalp；In addition, the present invention includes a cosmetics carrier, can be the carrier of diluent, dispersant or adenine, to promote
The formula of hair growth promoting agents is evenly distributed in skin surface, and the form of carrier can be liquid or solid lubricant, solvent, guarantor
Humectant, thickener or powder；Other than the active material and cosmetics carrier of the present invention, hair growth promoting agents also include often to make
For the additive and adjuvant in cosmetics, drug or dept. of dermatology field, such as hydrophily or lipophile gelling agent, hydrophilic or oleophylic
Activating agent, preservative, antioxidant, solvent, fragrance, filler, fungicide, deodorant, dyestuff or colorant, these additives and
The use scope of adjuvant accounts for the 0.01% to 10% of total weight percent.
It is of the invention in order to prove the influence of adenine or adenine salt content for hair growth ability in the present invention
Hair growth promoting agents make the hair tonic aqueous solution of four kinds of samples by different proportion, and proportional components are as shown in table 1, sample
Product preparation method includes：
(1) by adenine sulfuric acid with, menthol, polyethylene glycol -40, rilanit special, ethyl alcohol and part ion exchange
A solution is generated after water mixing, stirring；
(2) remaining ion exchange water is added in above-mentioned solution again, to form hair tonic aqueous solution.
1 hair lotion of table configures sample 1-4
(a) the hair tonic experiment of mouse is carried out
Above-mentioned sample 1-4 is applied to hair growth to recycle with static mouse to test, these mouse are
The hair of its behind is shaved off by scissors or razor, then the hair lotion of sample 1 to 4 is applied to the portion that its back is shaved off hair
Position, every ten mouse are one group, and each group smears the sample that ampoule is 0.2 milliliter, its hair after 14 and 28 days daily
The mean values of regenerated regional percentage are as shown in table 2.
2 hair lotion test result of table
As can be known from Table 2, the sample 2,3,4 that adenine sulfate is added has significant effect compared with sample 1, can deduce this
The hair growth of invention promotes ingredient to have very remarkable effect for hair growth.
(b) the hair tonic experiment of human body is carried out
The present invention has the effect of preventing from shaving one's head and promotes natural on-off cycles of hair growth, by the sample 3 of above-mentioned configuration, sample 4 and control
Processed group is applied on the scalp of 60 males with alopecia, twice a day, each 1ml deals, after continuously smearing four months,
Anthropometric test investigation is carried out through way of questionnaires, questionnaire test result is as shown in table 3.
3 test result of table
As can be known from Table 3, hair growth promoting agents of the invention, which contain, has the gland of significant curative effect fast natural on-off cycles of hair growth
Purine or adenine salt.
(c) configuration of clean hair-cream liquid is carried out
Preparation method and composition please refer to shown in following and table 4：
(c-1) first stage and second stage ingredient are mixed and made into solution respectively respectively；
(c-2) again by above-mentioned solution mixing system at clean hair-cream liquid.
Table 4 configures clean hair-cream liquid sample 5
| Ingredient | % (w/w) |
| First stage | |
| - 40 rilanit special of polyethylene glycol | 0.5 |
| Polysorbate20 (Tween-20) | 0.2 |
| Triton X-100 (Octoxynol 10) | 0.1 |
| Second stage | |
| Adenine sulfate | 0.02 |
| Menthol | 0.1 |
| Fragrance | 0.2 |
| Ion exchange water | 98.8 |
(d) configuration of shampoo is carried out
Preparation method and composition please refer to shown in following and table 5：
(d-1) hydroxylated cellulose (hydroxycellulose) is evenly distributed in by ion exchange water by a blender
In；
(d-2) after heating the solution to 70 DEG C, disodium ethylene diamine tetraacetate and sodium citrate are added until completely molten
Solution；
(d-3) above-mentioned solution is added into polyquaternium 7 until being completely dissolved；
(d-4) above-mentioned solution is cooled to 40 DEG C and adds sodium lauroyl sarcosine (Sodium laurosyl), lauroyl
Amine propyl betaine (lauric acid amido propylbetaine), cocamidopropyl propyl amide amine oxide
It (Cocamidopropylamine oxide) and lauramide MEA (Lauramide MEA) and is mixed；
(d-5) urea, propylben, adenine sulfate, menthol and fragrance are added, to generate shampoo.
The configuration hair washing water sample 6 of table 5
| Ingredient | % (w/w) |
| Hydroxylated cellulose | 1.0 |
| Disodium ethylene diamine tetraacetate | 0.1 |
| Sodium citrate | 0.2 |
| Polyquaternium 7 | 2 |
| Sodium lauroyl sarcosine | 10 |
| Lauroylamidopropyl betaine | 8 |
| Cocamidopropyl propyl amide amine oxide | 6 |
| Lauramide MEA | 6.2 |
| Urea | 0.3 |
| Propylben | 0.2 |
| Adenine sulfate | 0.05 |
| Menthol | 0.1 |
| Fragrance | 0.2 |
| Ion exchange water | 65.55 |
(e) configuration of hair moistening liquid is carried out
Preparation method and composition are as shown in table 6, and ion exchange water and polyquaternium 7 are thoroughly mixed, then added
Guar hydroxypropyltrimonium chloride, dimethyl copolyol, adenine sulfate and fragrance are to generate hair moistening liquid.
Table 6 configures hair moistening liquid sample 7
| Ingredient | % (w/w) |
| Polyquaternium 7 | 3.0 |
| Guar hydroxypropyltrimonium ammonium chloride | 0.3 |
| Dimethyl copolyol | 1.0 |
| Adenine sulfate | 0.02 |
| Fragrance | 0.5 |
| Ion exchange water | 95.2 |
(f) configuration of eyebrow and eyelash cleaning lotion is carried out
Preparation method and composition please refer to shown in following and table 7：
(f-1) first stage and second stage ingredient are mixed and made into solution respectively；
(f-2) above-mentioned solution mixing system is cleaned into lotion at eyebrow and eyelash again.
Table 7 configures eyebrow and eyelash cleaning lotion sample 8 and 9
| Sample 8 | Sample 9 | Control group 2 | |
| Ingredient | % (w/w) | ||
| First stage | |||
| - 40 rilanit special of polyethylene glycol | 0.5 | 0.5 | 0.5 |
| Tween-20 (polysorbate20) | 0.1 | 0.1 | 0.1 |
| Second stage | |||
| Adenine sulfate | 0.1 | 0.05 | 0 |
| Fragrance | 0.2 | 0.2 | 0.2 |
| Apirogen water | 99.0 | 99.05 | 99.1 |
(g) human test of eyelash cleaning lotion is carried out
The eyelash of the present invention cleans lotion, penetrates way of questionnaires below to carry out anthropometric test investigation, test object
For the sample 8 of above-mentioned configuration, sample 9 and control group 2 are applied to by cotton rod on the eyelash of 48 women, one day one
Secondary, each 0.5ml deals, for continuous smearing after three months, questionnaire test result is as shown in table 8.
8 test result of table
As seen from the results in Table 8, the ingredient of eyelash of the invention cleaning lotion contains adenine or adenine salt in eye
Eyelashes growth has notable effect.
(h) human test of eyebrow cleaning lotion is carried out
The eyebrow of the present invention cleans lotion, penetrates way of questionnaires below to carry out anthropometric test investigation, test object is
The sample 8 of above-mentioned configuration, sample 9 and control group 2 are applied to by cotton rod on the eyelash of 60 women, once a day,
Each 0.5ml deals, continuous to smear after two months, questionnaire test result is as shown in table 9.
9 test result of table
As seen from the results in Table 9, contain adenine or adenine salt in the ingredient of eyebrow of the invention cleaning lotion, to eye
Eyelashes growth has notable effect.
(i) the papilla cytothesis of people's hair corium is tested
By adenine promoted cytothesis effect can by weigh people's hair corium papilla cell quantity,
Under the conditions of following, compare the effect of adenosine and minoxidil (minoxidil), the results are shown in Figure 1；Measure hair
Adenine, adenosine and the minoxidil (minoxidil) contained in the cell culture fluid of corium papilla cell, group
It is comprising 0.002% adenine, adenosine and minoxidil (minoxidil), test method in：
(i-1) 0.002% adenine, adenosine and minoxidil (minoxidil) are prepared, and controls test hair
The medium of corium papilla cell；
(i-2) people's hair corium papilla cell is implanted into respectively in 96 lattice culture dishes, density be 5000 cells/
Lattice, and add in the culture solution to each lattice culture dish of 0.1ml；
(i-3) it is being implanted into cell 12, after 24,36,48 and 60 hours, reusing vision counter to calculate all cells
Quantity；
(i-4) from the result of Fig. 1 it is found that adenine can significantly promote the Regenerated energy of people's hair corium papilla cell
Power, therefore the hair growth promoting agents of the present invention have significant hair care effect, can promote the mankind or mammiferous hair growth energy
Power and falling off for hair can be prevented.
In conclusion the foregoing is merely a prefered embodiment of the invention, the patent protection model of the present invention is not thereby limited
It encloses, the scope of the claims of the invention should be subjected to the contents of the claims.
Claims (1)
1. adenine or adenine salt are fallen by promoting people's hair corium papilla cytothesis to prevent what falling stop was sent out in preparation
Send out the application in preventing agent, which is characterized in that the adenine or adenine salt are in the preventing agent of shaving one's head separately as falling
Send out the active material prevented.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510534291.7A CN105106027B (en) | 2010-11-22 | 2010-11-22 | Hair growth promoting agents |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105572969A CN102475633A (en) | 2010-11-22 | 2010-11-22 | Hair growth promoter |
| CN201510534291.7A CN105106027B (en) | 2010-11-22 | 2010-11-22 | Hair growth promoting agents |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105572969A Division CN102475633A (en) | 2010-11-22 | 2010-11-22 | Hair growth promoter |
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| Publication Number | Publication Date |
|---|---|
| CN105106027A CN105106027A (en) | 2015-12-02 |
| CN105106027B true CN105106027B (en) | 2018-08-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010105572969A Pending CN102475633A (en) | 2010-11-22 | 2010-11-22 | Hair growth promoter |
| CN201510534291.7A Active CN105106027B (en) | 2010-11-22 | 2010-11-22 | Hair growth promoting agents |
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| Application Number | Title | Priority Date | Filing Date |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445971A (en) * | 2012-05-31 | 2013-12-18 | 祥茂生活科技股份有限公司 | Composition and method for promoting hair growth |
| CN110051595A (en) * | 2019-03-14 | 2019-07-26 | 广州德谷个人护理用品有限公司 | Sliding shampoo of a kind of baked feeding silk of ginseng Zi Ran and preparation method thereof |
| CN109908053A (en) * | 2019-03-14 | 2019-06-21 | 广州德谷个人护理用品有限公司 | One kind, which is moistened, repairs hair washing lotion and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1646078A (en) * | 2002-04-09 | 2005-07-27 | 大塚制药株式会社 | Composition for cell proliferation |
| CN1878530A (en) * | 2003-11-11 | 2006-12-13 | 株式会社资生堂 | Method and composition for hair thickening |
| CN101217999A (en) * | 2005-07-08 | 2008-07-09 | 宝洁公司 | Personal care compositions and methods for the beautification of mammalian skin and hair |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007074602A1 (en) * | 2005-12-26 | 2007-07-05 | Lion Corporation | Cosmetic for scalp and hair |
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2010
- 2010-11-22 CN CN2010105572969A patent/CN102475633A/en active Pending
- 2010-11-22 CN CN201510534291.7A patent/CN105106027B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1646078A (en) * | 2002-04-09 | 2005-07-27 | 大塚制药株式会社 | Composition for cell proliferation |
| CN1878530A (en) * | 2003-11-11 | 2006-12-13 | 株式会社资生堂 | Method and composition for hair thickening |
| CN101217999A (en) * | 2005-07-08 | 2008-07-09 | 宝洁公司 | Personal care compositions and methods for the beautification of mammalian skin and hair |
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| Publication number | Publication date |
|---|---|
| CN102475633A (en) | 2012-05-30 |
| CN105106027A (en) | 2015-12-02 |
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