CN105081344A - Preparing technology of gold nanoparticles - Google Patents
Preparing technology of gold nanoparticles Download PDFInfo
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- CN105081344A CN105081344A CN201510519924.7A CN201510519924A CN105081344A CN 105081344 A CN105081344 A CN 105081344A CN 201510519924 A CN201510519924 A CN 201510519924A CN 105081344 A CN105081344 A CN 105081344A
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- reducing agent
- reducer
- acid solution
- stabilizer
- stabilizing agent
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Abstract
The invention relates to a preparing technology of gold nanoparticles. The preparing technology comprises the steps of solvent preparing, reducer adding and stabilizer adding. According to the solvent preparation step, 1% of reducer, 80% of chloroauric acid solution and 0.1% of stabilizer are prepared. According to the reducer adding step, the isometric reducer is added in the chloroauric acid solution and stirred. According to the stabilizer adding step, the stabilizer is added in the chloroauric acid solution with the reducer and stirred till colors change. The reducer is one or more of ethyl alcohol ultrasounds, white phosphorus, sodium borohydride and ascorbic acid. The stabilizer is 5-thiophenyl corrole. According to the preparing technology of the gold nanoparticles, the prepared product is better in color, sensibility, specificity and stability.
Description
Technical field
The present invention relates to nm of gold field, particularly relate to a kind of preparation technology of nanogold particle.
Background technology
Nm of gold (Nano-gold) refers to that the particle diameter of gold is the particle between 1-l00nm, is dispersed in the aqueous solution or oil solution.Nano-Au solution also claims aurosol (Goldsol), is the gold nano grain solution will formed after golden salt reduction, and along with the difference of nm of gold particle size, its color then shows as buff, pink, claret, peony, blue change successively.The chemist MichaelFaraday scholar that made pills of immortality inspires, prepare pure nanogold particle first, be referred to as " active gold (Activatedgold) " and the optics of its uniqueness, electricity and biological affinity are strong, can combine with multiple large biological molecule, and do not affect the critical natures such as its biologically active, establish the important foundation that it is applied to field of biological molecule.
When traditional handicraft prepares nanogold particle, problems faced is the particle diameter of the nanogold particle that crystallization goes out and the uniformity of shape, and nanogold particle adsorption citric acid and then electronegative, need to be exchanged by the surface molecular of complexity or electrostatic assembly reverses its surface charge, make it with the cohesive process of antibody in evenly cannot be wrapped quilt, can not be uniformly distributed in the solution, affect the color of product, sensitiveness, specificity and stability the most at last, limit the further application of nano Au particle.
Summary of the invention
The present invention, in order to solve the problem, provides a kind of preparation technology of nanogold particle, and the step comprised has the preparation of solvent, adds reducing agent, adds stabilizing agent;
The preparation of solvent: prepare volume fraction be the reducing agent of 1%, the chlorauric acid solution of 80% and 0.1% stabilizing agent.
Add reducing agent: the reducing agent adding equal proportion in chlorauric acid solution, and stir.
Add stabilizing agent: add stabilizing agent to the chlorauric acid solution being added with reducing agent, and stir, until occur that color changes.
Described reducing agent is one or more in EtOH Sonicate, white phosphorus, sodium borohydride, ascorbic acid.
Described stabilizing agent is 5-thiophenyl click.
The invention has the beneficial effects as follows: the preparation technology of a kind of nanogold particle of the present invention, the product colour prepared, sensitiveness, specificity and stability are all better.
Detailed description of the invention
Be described in detail below with reference to embodiments of the invention.
A preparation technology for nanogold particle, the step comprised has the preparation of solvent, adds reducing agent, adds stabilizing agent;
The preparation of solvent: prepare volume fraction be the reducing agent of 1%, the chlorauric acid solution of 80% and 0.1% stabilizing agent.
Add reducing agent: the reducing agent adding equal proportion in chlorauric acid solution, and stir.
Add stabilizing agent: add stabilizing agent to the chlorauric acid solution being added with reducing agent, and stir, until occur that color changes.
Described reducing agent is one or more in EtOH Sonicate, white phosphorus, sodium borohydride, ascorbic acid.
Described stabilizing agent is 5-thiophenyl click.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (3)
1. a preparation technology for nanogold particle, is characterized in that, the step comprised has the preparation of solvent, adds reducing agent, adds stabilizing agent;
The preparation of solvent: prepare volume fraction be the reducing agent of 1%, the chlorauric acid solution of 80% and 0.1% stabilizing agent;
Add reducing agent: the reducing agent adding equal proportion in chlorauric acid solution, and stir;
Add stabilizing agent: add stabilizing agent to the chlorauric acid solution being added with reducing agent, and stir, until occur that color changes.
2. the preparation technology of a kind of nanogold particle according to claim 1, is characterized in that, described reducing agent is one or more in EtOH Sonicate, white phosphorus, sodium borohydride, ascorbic acid.
3. the preparation technology of a kind of nanogold particle according to claim 2, is characterized in that, described stabilizing agent is 5-thiophenyl click.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510519924.7A CN105081344A (en) | 2015-08-21 | 2015-08-21 | Preparing technology of gold nanoparticles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510519924.7A CN105081344A (en) | 2015-08-21 | 2015-08-21 | Preparing technology of gold nanoparticles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105081344A true CN105081344A (en) | 2015-11-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510519924.7A Pending CN105081344A (en) | 2015-08-21 | 2015-08-21 | Preparing technology of gold nanoparticles |
Country Status (1)
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| CN (1) | CN105081344A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105771284A (en) * | 2016-05-11 | 2016-07-20 | 福州大学 | Bubble water color increasing agent and application method thereof |
| CN107520460A (en) * | 2017-07-26 | 2017-12-29 | 华南理工大学 | A kind of superfine nano gold/nano-cellulose composite solution and preparation method thereof |
| CN107598150A (en) * | 2017-08-15 | 2018-01-19 | 西北大学 | A kind of nano metal/red phosphorus composite and preparation method thereof |
-
2015
- 2015-08-21 CN CN201510519924.7A patent/CN105081344A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105771284A (en) * | 2016-05-11 | 2016-07-20 | 福州大学 | Bubble water color increasing agent and application method thereof |
| CN105771284B (en) * | 2016-05-11 | 2018-03-16 | 福州大学 | A kind of bubble-water increases color agent and its application method |
| CN107520460A (en) * | 2017-07-26 | 2017-12-29 | 华南理工大学 | A kind of superfine nano gold/nano-cellulose composite solution and preparation method thereof |
| CN107598150A (en) * | 2017-08-15 | 2018-01-19 | 西北大学 | A kind of nano metal/red phosphorus composite and preparation method thereof |
| CN107598150B (en) * | 2017-08-15 | 2019-08-16 | 西北大学 | A kind of nano metal/red phosphorus composite material and preparation method |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151125 |
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| WD01 | Invention patent application deemed withdrawn after publication |