CN105079548A

CN105079548A - Pharmaceutical preparation for treating gestational edema

Info

Publication number: CN105079548A
Application number: CN201510545888.1A
Authority: CN
Inventors: 卞毓平
Original assignee: Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
Current assignee: Nanjing Zhengkuan Pharmaceutical Technology Co Ltd
Priority date: 2015-08-31
Filing date: 2015-08-31
Publication date: 2015-11-25

Abstract

The invention belongs to the field of traditional Chinese medicine preparations and provides a pharmaceutical preparation for treating gestational edema. The pharmaceutical preparation is prepared from the following raw materials in parts by weight: 25 parts of valeriana hardwickii, 18 parts of Pararuellia delauayana, 20 parts of rhynchospora rubra, 25 parts of vitis amurensis, 18 parts of angelica sinensis, 20 parts of rhizome alismatis, 30 parts of radix scutellariae, 20 parts of ophiopogon japonicus, 15 parts of poria cocos, 10 parts of acanthopanax bark, 25 parts of mulberry twigs, 18 parts of cogon grass rhizome, 25 parts of herba artemisiae scopariae, 12 parts of magnolia bark, 12 parts of gardenia, 30 parts of stephania tetrandra, 30 parts of herba leonuri, 20 parts of herba ecliptae and 10 parts of glycyrrhiza uralensis. The pharmaceutical preparation can be used for treating gestational edema.

Description

A kind of pharmaceutical preparation for the treatment of edema during pregnancy

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical preparation and the preparation method and application that treat edema during pregnancy.

Background technology

After gestation, there is edema in the positions such as limbs appearance, claims " edema during pregnancy ", also known as " edema and distension during pregnancy ".Change mainly due to anemia of pregnant woman's endocrine, cause moisture and salt retention (sodium retention) in in-vivo tissue; In addition, the vein of gravid uterus compressing pelvic cavity and lower limb, hinders blood backflow, venous pressure is increased, therefore edema often occurs in limb far-end, based on foot and shank.The women being engaged in the work of standing especially is more obvious.The exception that edema can show as body weight at first increases (i.e. latent edema), weekly more than 0.5kg, or occurs pitting edema, namely the clinical visible edema that in body, hydrops too much causes, many by ankle, gradually prolong to shank, thigh, external genital, abdominal part, the depression of pressing.Facts have proved, Chinese medicine is of great significance treatment primary disease and prognosis tool, has potential advantage and wide DEVELOPMENT PROSPECT.

Summary of the invention

Goal of the invention: in order to solve the problem, the object of the present invention is to provide a kind of pharmaceutical preparation and the preparation method and application that treat edema during pregnancy.

Technical scheme: the object of the invention is by following scheme realize:

Treat a pharmaceutical preparation for edema during pregnancy, it is prepared by the raw material of following parts by weight: Radix et Rhizoma Iridis Sanguineae 25 parts, Herb Pararuelliae delavayanae 18 parts, large Herba Kylligac coloratae 20 parts, Caulis Vitis Amurensis 25 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Alismatis 20 parts, Radix Scutellariae 30 parts, Radix Ophiopogonis 20 parts, 15 parts, Poria, Cortex Acanthopancis 10 parts, Ramulus Mori 25 parts, Rhizoma Imperatae 18 parts, Herba Artemisiae Scopariae 25 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 12 parts, Radix Stephaniae Tetrandrae 30 parts, Herba Leonuri 30 parts, Herba Ecliptae 20 parts, 10 parts, Radix Glycyrrhizae.

The application of pharmaceutical preparation in the medicine of preparation treatment edema during pregnancy of described treatment edema during pregnancy.

Radix et Rhizoma Iridis Sanguineae is the fragrant ValerianahardwickiiWall. in phytolith limit, with root or all herbal medicine.Xia Qiucai, cleans and dries.Acrid, sweet, warm.Promoting blood flow to regulate menstruation, eliminating stasis to stop pain, spleen invigorating removing food stagnancy.For menoxenia, dysmenorrhea, amenorrhea, thromboangiitis obliterans, treating swelling and pain by traumatic injury, lumbago, rheumatic ostalgia, infantile malnutrition, neurasthenia; External training the body is itched.The present invention is with all herbal medicine.

Herb Pararuelliae delavayanae is the herb of the little luxuriant Herba Rostellulariae of acanthaceous plant happiness oak, and Classification system is Pararuelliadelauayana (Baill.) E.Hossain, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.Control pneumonia, tonsillitis, parotitis, scrofula, abscess sore, fracture, traumatic infection.

Large Herba Kylligac coloratae is the herb of sedge Herba Rhynchosporae Rubrae.Latin plant animal mineral name: Rhynchosporarubra (Lour.) Makino., gathers and stores: summer, autumn gather, and cleans, dries.Wind and heat dispersing; Dampness removing is treating stranguria.Main anemopyretic cold; Cough; Headache; Stranguria with turbid discharge.

Caulis Vitis Amurensis is Vitaceae Vitis plant Heisui River Fructus Vitis viniferae VitisamurensisRupr., with root, rattan, fruit medicine.Adopt root and fruit autumn: root, rattan: wind-expelling pain-stopping.For the outer pain of injury, rheumatic ostalgia, stomachache, stomachache, nervous headache, postoperative pain.Really: clearing away heat and promoting diuresis.Thirsty for dysphoria with smothery sensation, urinary tract infection, dysuria.The present invention is used as medicine with root.All the other medicines all meet standards of pharmacopoeia or are documented in Chinese medicine voluminous dictionary.

Beneficial effect: Chinese medicine is thought due to deficiency of spleen-YANG and kidneyYANG, functional activity of QI being not smooth, limbs generation swelling, nourish blood heat clearing away, inducing diuresis to remove edema of Radix et Rhizoma Iridis Sanguineae of the present invention, Herb Pararuelliae delavayanae, large Herba Kylligac coloratae, Caulis Vitis Amurensis, Radix Angelicae Sinensis, Rhizoma Alismatis, Radix Scutellariae, Radix Ophiopogonis, Poria, Cortex Acanthopancis is monarch drug, Ramulus Mori, Rhizoma Imperatae, Herba Artemisiae Scopariae, Cortex Magnoliae Officinalis, Fructus Gardeniae, Radix Stephaniae Tetrandrae, Herba Leonuri, Herba Ecliptae blood circulation promoting and blood stasis dispelling, strengthening spleen, tonifying kidney is monarch drug, Radix Glycyrrhizae is adjuvant, coordinating the actions of various ingredients in a prescription, full side's compatibility has effect of heat clearing away of nourishing blood, inducing diuresis to remove edema, is used for the treatment of edema during pregnancy.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1. prepare embodiment

1.1 take Radix et Rhizoma Iridis Sanguineae 25g, Herb Pararuelliae delavayanae 18g, large Herba Kylligac coloratae 20g, Caulis Vitis Amurensis 25g, Radix Angelicae Sinensis 18g, Rhizoma Alismatis 20g, Radix Scutellariae 30g, Radix Ophiopogonis 20g, Poria 15g, Cortex Acanthopancis 10g, Ramulus Mori 25g, Rhizoma Imperatae 18g, Herba Artemisiae Scopariae 25g, Cortex Magnoliae Officinalis 12g, Fructus Gardeniae 12g, Radix Stephaniae Tetrandrae 30g, Herba Leonuri 30g, Herba Ecliptae 20g, Radix Glycyrrhizae 10g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, incapsulate shell, the capsule of adult normal's 1 day consumption must be met.Be used for the treatment of edema during pregnancy.Oral, every bu is taken for twice sooner or later.

1.2 take Radix et Rhizoma Iridis Sanguineae 25g, Herb Pararuelliae delavayanae 18g, large Herba Kylligac coloratae 20g, Caulis Vitis Amurensis 25g, Radix Angelicae Sinensis 18g, Rhizoma Alismatis 20g, Radix Scutellariae 30g, Radix Ophiopogonis 20g, Poria 15g, Cortex Acanthopancis 10g, Ramulus Mori 25g, Rhizoma Imperatae 18g, Herba Artemisiae Scopariae 25g, Cortex Magnoliae Officinalis 12g, Fructus Gardeniae 12g, Radix Stephaniae Tetrandrae 30g, Herba Leonuri 30g, Herba Ecliptae 20g, Radix Glycyrrhizae 10g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add 50g starch, technique is granulated routinely, must meet the granule of adult normal's 1 day consumption.Be used for the treatment of edema during pregnancy.Oral, every bu is taken for twice sooner or later.

1.3 take Radix et Rhizoma Iridis Sanguineae 25g, Herb Pararuelliae delavayanae 18g, large Herba Kylligac coloratae 20g, Caulis Vitis Amurensis 25g, Radix Angelicae Sinensis 18g, Rhizoma Alismatis 20g, Radix Scutellariae 30g, Radix Ophiopogonis 20g, Poria 15g, Cortex Acanthopancis 10g, Ramulus Mori 25g, Rhizoma Imperatae 18g, Herba Artemisiae Scopariae 25g, Cortex Magnoliae Officinalis 12g, Fructus Gardeniae 12g, Radix Stephaniae Tetrandrae 30g, Herba Leonuri 30g, Herba Ecliptae 20g, Radix Glycyrrhizae 10g, add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1 hour, filters; Merging filtrate, concentrated, dry, add 50g starch, technique is granulated routinely, and tabletting, can obtain the tablet meeting adult normal's 1 day consumption.Be used for the treatment of edema during pregnancy.Oral, every bu is taken for twice sooner or later.

2. the present invention is to the clinical research of edema during pregnancy

2.1 physical data: inventor collects the out-patient of 50 routine edema during pregnancy altogether between in October ,-2013 in May, 2012, age 25-36 year, be divided at random: treatment group 25 example, blank group 25 example.The two groups of data such as age, state of an illness there was no significant differences, have comparability.

2.2 diagnostic criterias: patient has gestation performance, and uterus increases, and pregnancy tests are positive.After edema comes across the gestation period 3, be rich with lower limbs edema, when standing, edema increases the weight of.Check that blood pressure normally or slightly increases, urine protein can positive or negative, without dropsy of serous cavity, and point puerperium edema general nature disappearance.

2.3 test method

2.3.1 the oral the present invention for the treatment of group is according to the obtained granule of specific embodiment 1.2, sooner or later each once.30 days courses for the treatment of.

2.3.2 blank group oral placebo granule, sooner or later respectively once.30 days courses for the treatment of.

2.4 criterions of therapeutical effect and therapeutic outcome

2.4.1 criterion of therapeutical effect recovery from illness: patient's edema all disappears; The symptom such as sensation of oppression over the chest with shortness of breath, tastelessness is obviously improved; Take a turn for the better: patient's edema major part disappears, and the symptom such as sensation of oppression over the chest with shortness of breath, tastelessness makes moderate progress; Invalid: sings and symptoms is without improvement.

2.4.2 statistical result is treated in table 1.

Table 1 liang group comparitive study

Group	n	Recovery from illness	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	25	8	13	4	84
Blank group	25	1	2	22	12

Visible, the medicine that the present invention obtains can safe and effective treatment edema during pregnancy, and has no side effect.

Model case and curative effect:

Case 1, Pei, female, 26 years old age, swelling of the feet is started when conceived 6 months, whole body starts to swell subsequently, clinical symptoms: appearance extremity edema, thin lingual fur, clinical diagnosis is: edema during pregnancy, take the present invention according to after specific embodiment 1.1 obtained 1 course for the treatment of of capsule, symptom obviously alleviates, after continuing to take two courses for the treatment of, the symptoms such as edema all disappear, after give birth to a healthy girl baby.

Claims

1. treat the pharmaceutical preparation of edema during pregnancy for one kind, it is characterized in that, it is prepared by the raw material of following parts by weight: Radix et Rhizoma Iridis Sanguineae 25 parts, Herb Pararuelliae delavayanae 18 parts, large Herba Kylligac coloratae 20 parts, Caulis Vitis Amurensis 25 parts, Radix Angelicae Sinensis 18 parts, Rhizoma Alismatis 20 parts, Radix Scutellariae 30 parts, Radix Ophiopogonis 20 parts, 15 parts, Poria, Cortex Acanthopancis 10 parts, Ramulus Mori 25 parts, Rhizoma Imperatae 18 parts, Herba Artemisiae Scopariae 25 parts, Cortex Magnoliae Officinalis 12 parts, Fructus Gardeniae 12 parts, Radix Stephaniae Tetrandrae 30 parts, Herba Leonuri 30 parts, Herba Ecliptae 20 parts, 10 parts, Radix Glycyrrhizae.

2. treat the application of pharmaceutical preparation in the medicine for the treatment of edema during pregnancy of edema during pregnancy as claimed in claim 1.