CN105056140A - Traditional Chinese medicine composite for treating urticaria and eczema - Google Patents
Traditional Chinese medicine composite for treating urticaria and eczema Download PDFInfo
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- CN105056140A CN105056140A CN201510528082.1A CN201510528082A CN105056140A CN 105056140 A CN105056140 A CN 105056140A CN 201510528082 A CN201510528082 A CN 201510528082A CN 105056140 A CN105056140 A CN 105056140A
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Abstract
The invention relates to a traditional Chinese medicine composite for treating urticaria and eczema/ The composite comprises, by weight, 30 parts of forsythia suspensa, 30 parts of red-rooted salvia roots, 10 parts of stiff silkworm, 15 parts of prunella vulgaris, 6 parts of centipede, 3 parts of scorpions, 3 parts of periostracum cicada, 10 parts of lumbricus, 20 parts of angelica sinensis, 10 parts of white paeony roots, 10 parts of peony tree root-bark, 5 parts of pittosporum illicioides, 6 parts of white mustard seeds, 15 parts of cyperus rotundus, 6 parts of curcuma aromatica, 6 parts of Chinese thorowax roots, 10 parts of scutellaria baicalensis, 15 parts of eucommia ulmoides, 30 parts of rhizoma atractylodis macrocephalae, 10 parts of rhizoma alismatis, 6 parts of grifola, 10 parts of cinnamon, 15 parts of rhizoma atractylodis, 20 parts of pericarpium citri reticulatae, 15 parts of mangnolia officinalis, 15 parts of alpinia katsumadai, 10 parts of fructus amomi, 30 parts of mixtures of dark malt, scorched hawthorn fruits and scorched medicated leaven, 10 parts of achyranthes bidentata, 5 parts of licorice roots, 10 parts of costustoot and 10 parts of combined spicebush roots. According to the traditional Chinese medicine composite, natural traditional Chinese medicine ingredients are adopted, and the composite is wide in pharmaceutical source, low in cost, easy to prepare, little in toxic and side effect and remarkable in curative effect.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of Chinese medicine composition for the treatment of urticaria and eczema.
Background technology
Urticaria is the one limit office property edema reaction because skin, the expansion of mucosa thin vessels and permeability increase and occur.The welt do not waited sized by clinical manifestation, rapid rising disappears suddenly, and acute pruritus, leaves no trace more afterwards.Urticaria is common skin diseases, has the people of 15%-20% that a urticaria at least occurred in life.The morbidity of chronic urticaria accounts for 2/3 of urticaria, welt recurrent exerbation, and the persistent period was more than 3 months.About 50%-90% can not find the cause of disease, heavy time light during clinical manifestation, does not often for yearsly heal.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of urticaria and eczema.
In order to realize object of the present invention, the invention provides a kind of Chinese medicine composition for the treatment of urticaria and eczema, it comprises the material of following weight portion: Fructus Forsythiae 30 parts, Radix Salviae Miltiorrhizae 30 parts, Bombyx Batryticatus 10 parts, Spica Prunellae 15 parts, Scolopendra 6 parts, Scorpio 3 parts, Periostracum Cicadae 3 parts, Pheretima 10 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 10 parts, Cortex Moutan 10 parts, sea gold 5 parts, Semen Sinapis Albae 6 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 6 parts, Radix Bupleuri 6 parts, Radix Scutellariae 10 parts, the Cortex Eucommiae 15 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Rhizoma Alismatis 10 parts, Polyporus 6 parts, Cortex Cinnamomi 10 parts, Rhizoma Atractylodis 15 parts, Pericarpium Citri Reticulatae 20 parts, Cortex Magnoliae Officinalis 15 parts, Semen Alpiniae Katsumadai 15 parts, Fructus Amomi 10 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 30 parts, Radix Achyranthis Bidentatae 10 parts, 5 parts, Radix Glycyrrhizae, the Radix Aucklandiae 10 parts and the Radix Linderae 10 parts.
Preferably, the Chinese medicine composition for the treatment of urticaria of the present invention and eczema also comprises the material of following weight portion: youth-and-old-age 25 parts, Folium Bambusae 20 parts, Radix Et Rhizoma Tylophorae Ovatae 22 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 18 parts, Herba Ecliptae 20 parts, rabbit hair Artemisia 25 parts, Sinomenium acutum 20 parts, rock spring grass 15 parts and Herba Peperomiae Dindygulensis 12 parts.
More preferably, described Chinese medicine composition can be tablet, dispersible tablet, capsule, unguentum or decoction.
The present invention also provides the purposes of compositions in the Chinese medicine preparing treatment urticaria and eczema, described compositions comprises the material of following weight portion: Fructus Forsythiae 30 parts, Radix Salviae Miltiorrhizae 30 parts, Bombyx Batryticatus 10 parts, Spica Prunellae 15 parts, Scolopendra 6 parts, Scorpio 3 parts, Periostracum Cicadae 3 parts, Pheretima 10 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 10 parts, Cortex Moutan 10 parts, sea gold 5 parts, Semen Sinapis Albae 6 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 6 parts, Radix Bupleuri 6 parts, Radix Scutellariae 10 parts, the Cortex Eucommiae 15 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Rhizoma Alismatis 10 parts, Polyporus 6 parts, Cortex Cinnamomi 10 parts, Rhizoma Atractylodis 15 parts, Pericarpium Citri Reticulatae 20 parts, Cortex Magnoliae Officinalis 15 parts, Semen Alpiniae Katsumadai 15 parts, Fructus Amomi 10 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 30 parts, Radix Achyranthis Bidentatae 10 parts, 5 parts, Radix Glycyrrhizae, the Radix Aucklandiae 10 parts and the Radix Linderae 10 parts.
Preferably, described compositions also comprises the material of following weight portion: youth-and-old-age 25 parts, Folium Bambusae 20 parts, Radix Et Rhizoma Tylophorae Ovatae 22 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 18 parts, Herba Ecliptae 20 parts, rabbit hair Artemisia 25 parts, Sinomenium acutum 20 parts, rock spring grass 15 parts and Herba Peperomiae Dindygulensis 12 parts.
More preferably, described Chinese medicine can be tablet, dispersible tablet, capsule, unguentum or decoction.
In the present invention, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) is Herba indigoferae Pseudotinctoriae but three taste medicines, i.e. Fructus Hordei Germinatus (parched to brown), Fructus Crataegi (parched to brown), Massa Medicata Fermentata (parched to brown).Wherein, the weight of this three tastes medicine is identical.
Chinese medicine composition of the present invention interacts, and synergism is evident in efficacy, highly widelys popularize.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment 1 unguentum of the present invention
Take Fructus Forsythiae 30 grams, Radix Salviae Miltiorrhizae 30 grams, Bombyx Batryticatus 10 grams, Spica Prunellae 15 grams, Scolopendra 6 grams, Scorpio 3 grams, Periostracum Cicadae 3 grams, Pheretima 10 grams, Radix Angelicae Sinensis 20 grams, the Radix Paeoniae Alba 10 grams, Cortex Moutan 10 grams, sea gold 5 grams, Semen Sinapis Albae 6 grams, Rhizoma Cyperi 15 grams, Radix Curcumae 6 grams, Radix Bupleuri 6 grams, Radix Scutellariae 10 grams, the Cortex Eucommiae 15 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Rhizoma Alismatis 10 grams, Polyporus 6 grams, Cortex Cinnamomi 10 grams, Rhizoma Atractylodis 15 grams, Pericarpium Citri Reticulatae 20 grams, Cortex Magnoliae Officinalis 15 grams, Semen Alpiniae Katsumadai 15 grams, Fructus Amomi 10 grams, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 30 grams, Radix Achyranthis Bidentatae 10 grams, 5 grams, Radix Glycyrrhizae, the Radix Aucklandiae 10 grams and the Radix Linderae 10 grams, pulverize, cross 60 mesh sieves, add 150 grams, vaseline and lanoline 150 grams, stir, obtain.
Embodiment 2 unguentum of the present invention
Take Fructus Forsythiae 30 grams, Radix Salviae Miltiorrhizae 30 grams, Bombyx Batryticatus 10 grams, Spica Prunellae 15 grams, Scolopendra 6 grams, Scorpio 3 grams, Periostracum Cicadae 3 grams, Pheretima 10 grams, Radix Angelicae Sinensis 20 grams, the Radix Paeoniae Alba 10 grams, Cortex Moutan 10 grams, sea gold 5 grams, Semen Sinapis Albae 6 grams, Rhizoma Cyperi 15 grams, Radix Curcumae 6 grams, Radix Bupleuri 6 grams, Radix Scutellariae 10 grams, the Cortex Eucommiae 15 grams, the Rhizoma Atractylodis Macrocephalae 30 grams, Rhizoma Alismatis 10 grams, Polyporus 6 grams, Cortex Cinnamomi 10 grams, Rhizoma Atractylodis 15 grams, Pericarpium Citri Reticulatae 20 grams, Cortex Magnoliae Officinalis 15 grams, Semen Alpiniae Katsumadai 15 grams, Fructus Amomi 10 grams, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 30 grams, Radix Achyranthis Bidentatae 10 grams, 5 grams, Radix Glycyrrhizae, the Radix Aucklandiae 10 grams, the Radix Linderae 10 grams, youth-and-old-age 25 grams, Folium Bambusae 20 grams, Radix Et Rhizoma Tylophorae Ovatae 22 grams, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 18 grams, Herba Ecliptae 20 grams, rabbit hair Artemisia 25 grams, Sinomenium acutum 20 grams, rock spring grass 15 grams and Herba Peperomiae Dindygulensis 12 grams, pulverize, cross 60 mesh sieves, add 150 grams, vaseline and lanoline 150 grams, stir, obtain.
Experimental example
Diagnostic criteria
Formulate with reference to " People's Republic of China's traditional Chinese medicine industry standard disease of tcm Standardization of diagnosis and curative effect ", " tcm symptom and disease diagnostics ", " urticaria practice guidelines (2007 editions) ", " practical Dermatology (the 3rd edition) ", " skin cypridology " (sixth version) of the formulation of skin cypridology branch of Chinese Medical Association, " Surgery of Chinese Medicine " (the 5th edition).
Western medicine diagnose standard
1. break out, do not wait sized by skin lesion, the edemous speckle that differs of shape, boundary is clear.
Fall when 2. rising during erythra, violent pruritus, skin lesion appearing without definite location, steps back and leaves no trace.
3. some cases can have abdominal pain diarrhea, or has the disease such as heating, arthralgia.Severe patient can have dyspnea, even causes and suffocates.
4. dermatograph test is positive.
5. erythra did not heal or was repeatedly interrupted an author through more than 3 months is chronic urticaria.
Tcm diagnosis standard
1. primary symptom: skin occurs pruritic welt, skin lesion appearing without definite location, suddenly play delitescence, do not stay any vestige after disappearing, the course of disease is more than three months.
2. double disease: being irritable and getting angry easily, distending pain in the chest and hypochondrium, abdominal distention poor appetite, sleepy drowsiness or insomnia and dreamful sleep, extremity weakness etc.Light red tongue or red.Tongue is greasy or yellow greasy in vain.Stringy and rolling pulse or stringy and thready pulse.
Note: tongue fur, pulse condition specifically describe, but do not do integration requirement.The double disease of primary symptom more than+2 can be made a definite diagnosis.
Inclusive criteria
1. meet Chronic urticaria diagnostic criteria.
2.18-65 year, male or female.
3. sufferers themselves or its family members know the inside story and agree to.
Exclusion standard
1 took corticosteroid medication in nearly two weeks or took antihistaminic in nearly one week or corticosteroid medication is crossed in external.
2 gestation, women breast-feeding their children; Merge liver, kidney, the heart, brain and hemopoietic system serious disease and psychotic, tumor, patient.
3 some special work posts, as driver, work high above the ground person etc.
4 pairs of trial drug allergy sufferers.
The urticaria of 5 specific types.
Selector close standard of stating patient 100 example, wherein man 50 example, female 50 example, patient age 22-58 year, the mean age be (36 ± 4) year, be two groups by patient, be respectively treatment group 1 and treatment group 2, often group has 50 routine patients.Two groups of Genders, age, the course of disease, symptom there are no significant difference, have comparability (P > 0.05).
Treatment group 1 uses the unguentum of preparation in embodiment 1 to treat, every day three times, each affected part using 15 grams of unguentum to be coated in patient equably, continuously treatment 2 weeks.
Treatment group 2 uses the unguentum of preparation in embodiment 2 to treat, every day three times, each affected part using 15 grams of unguentum to be coated in patient equably, continuously treatment 2 weeks.
Method for estimating curative effect
With reference to the standard of the MILORD of Europe nineteen ninety-five, adopt level Four point system, respectively the change of the pruritus degree before and after patient treatment, welt size, welt number, welt color is marked.
Pruritus degree
0 point: without pruritus.
1 point: slight pruritus, does not affect sleep.
2 points: moderate pruritus, impact sleep, still can stand.
3 points: serious pruritus, has a strong impact on sleep, cannot stand.
Welt size
0 point: without welt.
1 point: welt diameter≤2cma
2 points: welt diameter > 2cm, < 5cm
3 points: welt diameter >=5cm.
Welt number
0 point: without welt.
1 point: welt≤10.
2 points: welt > 10, < 20
3 points: welt >=20.
Welt color
0 point: the colour of skin is normal.
1 point: cutaneous protuberance, color is normal.
2 points: cutaneous protuberance, color is light red.
3 points: cutaneous protuberance, color is scarlet.
Therapeutic index=[before (before treatment the rear integration of integration-treatment)/treatment integration] X100%
Recovery from illness: welt all disappears, pruritus disappears, therapeutic index >=90%.
Effective: welt major part disappears, and pruritus obviously alleviates, 60%≤therapeutic index < 90%.
Effective: welt partial remission, pruritus alleviates to some extent, 30%≤therapeutic index < 60%.
Invalid: welt disappears not obvious, pruritus does not alleviate, or symptom is counter increases the weight of, therapeutic index < 30%.
Statistical method
Utilize SPSS13.0 software to process and analyze to experimental data, measurement data is with mean ± standard deviation
represent, adopt t inspection, enumeration data adopts χ
2inspection, P < 0.05 represents that difference has statistical significance.
Therapeutic outcome
For treatment group 1, recovery from illness 20 example, effective 12 examples, effective 10 examples, invalid 8 examples, total effective rate is 84%; For treatment group 2, recovery from illness 24 example, effective 11 examples, effective 13 examples, invalid 2 examples, total effective rate is 96%.Two groups of total effective rate comparing differences have statistical significance (P < 0.05).The effect for the treatment of group 2 is better than the effect for the treatment of group 1.
Carry out the monitoring of blood, urine, stool routine examination and hepatic and renal function to two groups of patients before and after treatment, in time monitoring untoward reaction occurs, and it compares and sees the following form:
Claims (6)
1. treat the Chinese medicine composition of urticaria and eczema for one kind, it is characterized in that, it comprises the material of following weight portion: Fructus Forsythiae 30 parts, Radix Salviae Miltiorrhizae 30 parts, Bombyx Batryticatus 10 parts, Spica Prunellae 15 parts, Scolopendra 6 parts, Scorpio 3 parts, Periostracum Cicadae 3 parts, Pheretima 10 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 10 parts, Cortex Moutan 10 parts, sea gold 5 parts, Semen Sinapis Albae 6 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 6 parts, Radix Bupleuri 6 parts, Radix Scutellariae 10 parts, the Cortex Eucommiae 15 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Rhizoma Alismatis 10 parts, Polyporus 6 parts, Cortex Cinnamomi 10 parts, Rhizoma Atractylodis 15 parts, Pericarpium Citri Reticulatae 20 parts, Cortex Magnoliae Officinalis 15 parts, Semen Alpiniae Katsumadai 15 parts, Fructus Amomi 10 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 30 parts, Radix Achyranthis Bidentatae 10 parts, 5 parts, Radix Glycyrrhizae, the Radix Aucklandiae 10 parts and the Radix Linderae 10 parts.
2. the Chinese medicine composition for the treatment of urticaria according to claim 1 and eczema, it is characterized in that, it also comprises the material of following weight portion: youth-and-old-age 25 parts, Folium Bambusae 20 parts, Radix Et Rhizoma Tylophorae Ovatae 22 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 18 parts, Herba Ecliptae 20 parts, rabbit hair Artemisia 25 parts, Sinomenium acutum 20 parts, rock spring grass 15 parts and Herba Peperomiae Dindygulensis 12 parts.
3. the Chinese medicine composition for the treatment of urticaria according to claim 1 and 2 and eczema, is characterized in that, described Chinese medicine composition can be tablet, dispersible tablet, capsule, unguentum or decoction.
4. the purposes of compositions in the Chinese medicine preparing treatment urticaria and eczema, it is characterized in that, described compositions comprises the material of following weight portion: Fructus Forsythiae 30 parts, Radix Salviae Miltiorrhizae 30 parts, Bombyx Batryticatus 10 parts, Spica Prunellae 15 parts, Scolopendra 6 parts, Scorpio 3 parts, Periostracum Cicadae 3 parts, Pheretima 10 parts, Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 10 parts, Cortex Moutan 10 parts, sea gold 5 parts, Semen Sinapis Albae 6 parts, Rhizoma Cyperi 15 parts, Radix Curcumae 6 parts, Radix Bupleuri 6 parts, Radix Scutellariae 10 parts, the Cortex Eucommiae 15 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Rhizoma Alismatis 10 parts, Polyporus 6 parts, Cortex Cinnamomi 10 parts, Rhizoma Atractylodis 15 parts, Pericarpium Citri Reticulatae 20 parts, Cortex Magnoliae Officinalis 15 parts, Semen Alpiniae Katsumadai 15 parts, Fructus Amomi 10 parts, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 30 parts, Radix Achyranthis Bidentatae 10 parts, 5 parts, Radix Glycyrrhizae, the Radix Aucklandiae 10 parts and the Radix Linderae 10 parts.
5. purposes according to claim 4, it is characterized in that, described compositions also comprises the material of following weight portion: youth-and-old-age 25 parts, Folium Bambusae 20 parts, Radix Et Rhizoma Tylophorae Ovatae 22 parts, Flos Ixorae Chinensis (Cacumen et Folium Clerodendri paniculati) 18 parts, Herba Ecliptae 20 parts, rabbit hair Artemisia 25 parts, Sinomenium acutum 20 parts, rock spring grass 15 parts and Herba Peperomiae Dindygulensis 12 parts.
6. the purposes according to claim 4 or 5, is characterized in that, described Chinese medicine can be tablet, dispersible tablet, capsule, unguentum or decoction.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2560601A (en) * | 2016-11-29 | 2018-09-19 | Zhejiang Strong Pharmaceutical Co Ltd | Pharmaceutical composition for treating eczema and method for preparation thereof |
-
2015
- 2015-08-25 CN CN201510528082.1A patent/CN105056140A/en active Pending
Non-Patent Citations (2)
| Title |
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| 张清华: "从方药统计探析荨麻疹复方配伍规律", 《成都中医药硕士论文》 * |
| 陶航: "消疹汤治疗胃肠型尊麻疹15例报告", 《中医杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2560601A (en) * | 2016-11-29 | 2018-09-19 | Zhejiang Strong Pharmaceutical Co Ltd | Pharmaceutical composition for treating eczema and method for preparation thereof |
| US10413582B2 (en) | 2016-11-29 | 2019-09-17 | Zhejiang Strong Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating eczema and method for preparation thereof |
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