CN105055803A - Itching-relieving condensate and preparation method thereof - Google Patents
Itching-relieving condensate and preparation method thereof Download PDFInfo
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- CN105055803A CN105055803A CN201510547183.3A CN201510547183A CN105055803A CN 105055803 A CN105055803 A CN 105055803A CN 201510547183 A CN201510547183 A CN 201510547183A CN 105055803 A CN105055803 A CN 105055803A
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Abstract
The invention relates to itching-relieving condensate and a preparation method thereof. The itching-relieving condensate is characterized by comprising, by weight, the effective components of 0.1-5 parts of radix sophorae flavescentis extract, 0.1-5 parts of aloe barbadensis extract, 0.1-5 parts of centella extract and 0.01-1 part of menthol. Tests prove that the itching-relieving condensate is free of stimulation, good in treatment effect and high in clarity.
Description
Technical field
The present invention relates to a kind of antipruritic condensation and preparation method thereof.
Background technology
Very itch after mosquito bite summer and annoying patient unbearably always.At present, the product on market or be the product of chemosynthesis character, has the shortcoming such as stimulation, toxic side effect, is especially not suitable for damaged skin and uses; And there is onset slowly in the product of Chinese medicine ingredients, the shortcomings such as effect is imprecise.
Summary of the invention
The object of this invention is to provide the itch-stopping dew that a kind of new effect is obvious and safe and non-stimulating.
In order to achieve the above object, the present invention adopts following scheme:
The effective ingredient of this antipruritic condensation comprises: Radix Sophorae Flavescentis extract, Aloe vulgaris leaf extract, Herba Centellae extract, menthol.
The preparation method of this antipruritic condensation effective ingredient Radix Sophorae Flavescentis extract, Aloe vulgaris leaf extract, Herba Centellae extract is respectively:
(1) preparation method of Radix Sophorae Flavescentis extract: get Radix Sophorae Flavescentis powder and be broken into coarse powder, with the l% soak with hydrochloric acid 2h of 6 times amount, reflux, extract, 3 times, merging filtrate; Filtrate is adjusted to neutrality with sodium hydroxide, then concentrated thick paste, then adds sodium hydroxide adjustment pH to 11; Add 95% ethanol, make alcohol content be 80%, reflux, extract, 2h, alcohol extract is condensed into cream, dry, pulverize into fine powder, obtain Radix Sophorae Flavescentis extract;
(2) preparation method of Aloe vulgaris leaf extract: get Aloe powder and be broken into coarse powder, heating and refluxing extraction 2 times, at every turn with 50% ethanol of 15 times of pH=5, each 1 hour, merge alcohol extract and be condensed into cream, dry, be ground into fine powder, obtain Aloe vulgaris leaf extract;
(3) preparation method of Herba Centellae extract: get Herba Centellae and be ground into coarse powder, heating and refluxing extraction 2 times, at every turn with 12 times of 60% ethanol, each 2 hours, merge the concentrated solution that alcohol extract is condensed into 1.04g/ml concentration, upper D101 macroporous resin column, after washing impurity with water, use the ethanol of 60% again, the speed of 3ml/min carries out eluting, collects eluent and is condensed into cream, dry, be ground into fine powder, obtain Herba Centellae extract.
The parts by weight of this antipruritic condensation effective ingredient are as follows: Radix Sophorae Flavescentis extract 0.1-5 part, Aloe vulgaris leaf extract 0.1-5 part, Herba Centellae extract 0.1-5 part, menthol 0.01-1 part.
Best, the parts by weight of this antipruritic condensation effective ingredient are as follows: Radix Sophorae Flavescentis extract 1 part, Aloe vulgaris leaf extract 2 parts, Herba Centellae extract 2 parts, menthol 0.15 part.
The preparation method of this antipruritic condensation comprises the following steps:
(1) be distributed in redistilled water by nano silicon SiO2 solid according to the ratio ultrasonic cell disintegration instrument of 1g:100mL, after stirring 24h under 90 DEG C of conditions, centrifugalize product, and lyophilization, obtain the SiO2 activated; Again the SiO2 ultrasonic cell disintegration instrument of activation is distributed in redistilled water, then under high-speed stirred condition, 3-aminopropyl-triethoxysilane (APTES) is dripped, APTES is 1:4 with the mol ratio of (APTES+SiO2), and regulate the pH value of solution to be about 10,24h is stirred, centrifugalize product at 40 DEG C, and with redistilled water supersound washing product three times, lyophilization, obtains silane coupler modified SiO2;
(2) get Radix Sophorae Flavescentis extract, Aloe vulgaris leaf extract, Herba Centellae extract and menthol 70% dissolve with ethanol solution, make the effective ingredient alcohol mixeding liquid of 20% concentration;
(3) by silane coupler modified SiO2 nanoparticle ultrasonic disperse in redistilled water, forming concentration is the dispersion liquid of 10mg/mL, then the effective ingredient alcohol mixeding liquid that quality is silane coupler modified SiO2 nanoparticle 5% is added, 400rpm stirs 2h, allows effective ingredient and nanoparticle reach adsorption-desorption and balances; Under pH meter instruction, regulating the pH value of mixed liquor to being about 4.7 (when ie in solution is the most muddy), continuing to stir this mixed liquor 2h, centrifugalize product, and retain supernatant, use redistilled water centrifuge washing, last lyophilization, obtain the effective ingredient mixture of microencapsulation;
(4) the effective ingredient mixture of microencapsulation is added adjuvant, make condensation.
The effective ingredient mixture of this antipruritic condensation microencapsulation, the composition of adjuvant and weight proportion are: the effective ingredient mixture 50% of microencapsulation, carbomer 1%, propylene glycol 5%, ethanol 5%, sodium hydroxide 0.4%, diazolidinyl urea 0.0784%, iodine propilolic alcohol butyl mephenesin Carbamate 0.0016%, CI42090 pigment 0.001%, CI19140 pigment 0.0005%, water surplus, make condensation.
The preparation method of this antipruritic condensation is: with propylene glycol, carbomer dispersion is even, add water, ethanol, the effective ingredient mixture of microencapsulation, diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, CI42090 pigment, CI19140 pigment successively, stir, until carbomer swelling evenly after regulate pH with sodium hydroxide, obtain antipruritic condensation.
The invention has the beneficial effects as follows:
1) the antipruritic condensation adopting the inventive method to prepare, itching-relieving action is obvious, and safe and non-stimulating.
2) the antipruritic condensation adopting the inventive method to prepare, curative effect is better than PIYANPING, is also better than the compound recipe that Radix Sophorae Flavescentis extract, Aloe vulgaris leaf extract, Herba Centellae extract and menthol form.
3) the antipruritic condensation adopting the inventive method to prepare, clarity is higher, and color and luster is good.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described in detail, but should not be construed as limitation of the present invention.
Embodiment 1:
The preparation method of antipruritic condensation, its step is as follows:
(1) preparation method of Radix Sophorae Flavescentis extract: get Radix Sophorae Flavescentis powder and be broken into coarse powder, with the l% soak with hydrochloric acid 2h of 6 times amount, reflux, extract, 3 times, merging filtrate; Filtrate is adjusted to neutrality with sodium hydroxide, then concentrated thick paste, then adds sodium hydroxide adjustment pH to 11; Add 95% ethanol, make alcohol content be 80%, reflux, extract, 2h, alcohol extract is condensed into cream, dry, pulverize into fine powder, obtain Radix Sophorae Flavescentis extract;
(2) preparation method of Aloe vulgaris leaf extract: get Aloe powder and be broken into coarse powder, heating and refluxing extraction 2 times, at every turn with 50% ethanol of 15 times of pH=5, each 1 hour, merge alcohol extract and be condensed into cream, dry, be ground into fine powder, obtain Aloe vulgaris leaf extract;
(3) preparation method of Herba Centellae extract: get Herba Centellae and be ground into coarse powder, heating and refluxing extraction 2 times, at every turn with 12 times of 60% ethanol, each 2 hours, merge the concentrated solution that alcohol extract is condensed into 1.04g/ml concentration, upper D101 macroporous resin column, after washing impurity with water, use the ethanol of 60% again, the speed of 3ml/min carries out eluting, collects eluent and is condensed into cream, dry, be ground into fine powder, obtain Herba Centellae extract.
(4) be distributed in redistilled water by nano silicon SiO2 solid according to the ratio ultrasonic cell disintegration instrument of 1g:100mL, after stirring 24h under 90 DEG C of conditions, centrifugalize product, and lyophilization, obtain the SiO2 activated; Again the SiO2 ultrasonic cell disintegration instrument of activation is distributed in redistilled water, then under high-speed stirred condition, 3-aminopropyl-triethoxysilane (APTES) is dripped, APTES is 1:4 with the mol ratio of (APTES+SiO2), and regulate the pH value of solution to be about 10,24h is stirred, centrifugalize product at 40 DEG C, and with redistilled water supersound washing product three times, lyophilization, obtains silane coupler modified SiO2;
(5) get Radix Sophorae Flavescentis extract 1 part, Aloe vulgaris leaf extract 2 parts, Herba Centellae extract 2 parts, menthol 0.15 part and menthol 70% dissolve with ethanol solution, make the effective ingredient alcohol mixeding liquid of 20% concentration;
(6) by silane coupler modified SiO2 nanoparticle ultrasonic disperse in redistilled water, forming concentration is the dispersion liquid of 10mg/mL, then the effective ingredient alcohol mixeding liquid that quality is silane coupler modified SiO2 nanoparticle 5% is added, 400rpm stirs 2h, allows effective ingredient and nanoparticle reach adsorption-desorption and balances; Under pH meter instruction, regulating the pH value of mixed liquor to being about 4.7 (when ie in solution is the most muddy), continuing to stir this mixed liquor 2h, centrifugalize product, and retain supernatant, use redistilled water centrifuge washing, last lyophilization, obtain the effective ingredient mixture of microencapsulation;
(7) the effective ingredient mixture of microencapsulation is added adjuvant, make condensation.
The effective ingredient mixture of this antipruritic condensation microencapsulation, the composition of adjuvant and weight proportion are: the effective ingredient mixture 60% of microencapsulation, carbomer 1%, propylene glycol 5%, ethanol 5%, sodium hydroxide 0.4%, diazolidinyl urea 0.0784%, iodine propilolic alcohol butyl mephenesin Carbamate 0.0016%, CI42090 pigment 0.001%, CI19140 pigment 0.0005%, water surplus, make condensation.
Comparative example
Method for making: get Radix Sophorae Flavescentis extract 0.1%, Aloe vulgaris leaf extract 0.2%, Herba Centellae extract 0.2%, menthol 0.015%, carbomer 1%, propylene glycol 5%, ethanol 5%, sodium hydroxide 0.4%, diazolidinyl urea 0.0784%, iodine propilolic alcohol butyl mephenesin Carbamate 0.0016%, CI42090 pigment 0.001%, CI19140 pigment 0.0005%, water surplus, make condensation.
Test example
Embodiment 1 and comparative example are carried out pharmacodynamic experiment.
1 rabbit repeatedly irritation test
1.1, material and animal subject
Experiment material: the embodiment of the present invention 1, comparative example.
Laboratory animal: regular grade rabbit 8, male and female half and half, body weight: 1.86-1.94kg.Thered is provided by laboratory animal research center, Hubei Province, experimental animal production licence number is SCXK (Hubei Province) 2008-0005, the experimental animal certification of fitness number: NO.00020904.To Health survey before given the test agent 3 days, Pass Test requirement.
1.2, test method
(1) dosage and grouping: test to establish and protect embodiment and each 1 group of comparative example, adopts consubstantiality left and right sides self-contrast method, often organizes 4 rabbit.Embodiment 1 group and comparative example 1 group of equal administered dose: 0.5g/ rabbit.
(2) preparation before testing the selecting and test of rabbit: before test, 24h carries out cropping to family's rabbit back spinal column both sides battery powered shaver, the left and right each 3cm × 3cm of unhairing scope.Give again and carefully to check the skin of unhairing whether damaged because of unhairing before given the test agent, have the skin of damage to test.
(3) tested rabbit is fixed, get that the antipruritic condensation of 0.5g to be applied on the right side of a rabbit back on plucked skin, application area is 2.5cm × 2.5cm, smear every day once, smear 14 days continuously; Answer cropping before smearing at every turn.Depilation district, left side does not process and makes own control.
(4) experimental observation index: from second day, removes residual given the test agent with warm water, observed result after 1 hour, by the scoring of " cosmetics health specification " (version in 2007) skin wound repair standards of grading, the results are shown in Table 1, table 2.
The antipruritic condensation of table 1 embodiment 1 is to rabbit repeatedly irritation test result
The antipruritic condensation of table 2 comparative example is to rabbit repeatedly irritation test result
Conclusion: through observe, embodiment 1 treated animal shows without systemic toxicity profiles, the local skin that tested material is smeared without the performance such as erythema and edema, to rabbit repeatedly skin irritation be non-stimulated; Comparative example group shows without systemic toxicity profiles, and after repeatedly smearing, the performance such as erythema and edema appears in the local skin that part tested material is smeared, to rabbit repeatedly skin irritation be a small amount of stimulation.Illustrate that effective ingredient is after microencapsulation, product zest can be reduced.
The test of 2 itching-relieving actions
2.1, material and animal subject
Experiment material: the embodiment of the present invention 1, comparative example, PIYANPING, condensation substrate.
The preparation method of condensation substrate: carbomer 1%, propylene glycol 5%, ethanol 5%, sodium hydroxide 0.4%, diazolidinyl urea 0.0784%, iodine propilolic alcohol butyl mephenesin Carbamate 0.0016%, CI42090 pigment 0.001%, CI19140 pigment 0.0005%, water surplus, makes condensation substrate.
Laboratory animal: Cavia porcellus 40, male and female half and half, body weight: 18.5-21.4g.Thered is provided by laboratory animal research center, Hubei Province, experimental animal production licence number is SCXK (Hubei Province) 2008-0005, the experimental animal certification of fitness number: NO.00020904.To Health survey before given the test agent 3 days, Pass Test requirement.
2.2, test method
Latter 24 hours of the right back foot depilation of animal, with instep scratch after sand paper, with a small amount of oozing of blood for degree, then animal is divided into 4 groups at random, respectively at the antipruritic condensation 0.5g/kg of its abrasion even spread embodiment 1, comparative example condensation 0.5g/kg, PIYANPING 0.5g/kg, condensation substrate 0.5g/kg.0.01%, 0.02%, 0.03% is dripped successively at its abrasion after 30min ... 1% hydrochloric acid histamine 0.05ml/ only, each interval time is 3min, and record each animal and occur licking Histamine concentrations when foot reacts, this concentration is itch-threshold, result t checks, and the results are shown in Table 3.
Table 3 causes Cavia porcellus foot pruritus to hydrochloric acid histamine and to itch the impact (X ± s) of threshold
| Group | Mus number (only) | Itch-threshold ug/ml |
| Condensation matrix group | 10 | 11.5±5.5 |
| PIYANPING group | 10 | 68.4±8.7 |
| Embodiment 1 group | 10 | 98.1±15.4 |
| Comparative example group | 10 | 65.7±12.3 |
Conclusion: embodiment 1 group, comparative example group, PIYANPING group compare with condensation matrix group, P<0.01 has pole significant difference; Comparative example group compares with PIYANPING group, there was no significant difference; Embodiment 1 group compares with comparative example group, PIYANPING group, and P<0.05, has significant difference.Illustrate that embodiment 1 group of antipruritic effect is definite, and curative effect is better than PIYANPING and comparative example group.
In addition, in test of pesticide effectiveness process, it is well a lot of that we return the clarity finding sample prepared by embodiment 1 group of sample prepared obvious comparative example group, may be because alcohol soluble active principals dissolubility in water is not high, if without the process of preparation technique, fractions will be had can not dissolve completely, be suspended in condensation, and the effective ingredient after microencapsulation, dissolubility increases substantially, be dissolved completely in solvent, therefore clarity is good.
Claims (7)
1. an antipruritic condensation, is characterized in that effective ingredient comprises Radix Sophorae Flavescentis extract, Aloe vulgaris leaf extract, Herba Centellae extract, menthol.
2. antipruritic condensation as claimed in claim 1, is characterized in that the preparation method of effective ingredient Radix Sophorae Flavescentis extract, Aloe vulgaris leaf extract, Herba Centellae extract is respectively:
(1) preparation method of Radix Sophorae Flavescentis extract: get Radix Sophorae Flavescentis powder and be broken into coarse powder, with the l% soak with hydrochloric acid 2h of 6 times amount, reflux, extract, 3 times, merging filtrate; Filtrate is adjusted to neutrality with sodium hydroxide, then concentrated thick paste, then adds sodium hydroxide adjustment pH to 11; Add 95% ethanol, make alcohol content be 80%, reflux, extract, 2h, alcohol extract is condensed into cream, dry, pulverize into fine powder, obtain Radix Sophorae Flavescentis extract;
(2) preparation method of Aloe vulgaris leaf extract: get Aloe powder and be broken into coarse powder, heating and refluxing extraction 2 times, at every turn with 50% ethanol of 15 times of pH=5, each 1 hour, merge alcohol extract and be condensed into cream, dry, be ground into fine powder, obtain Aloe vulgaris leaf extract;
(3) preparation method of Herba Centellae extract: get Herba Centellae and be ground into coarse powder, heating and refluxing extraction 2 times, at every turn with 12 times of 60% ethanol, each 2 hours, merge the concentrated solution that alcohol extract is condensed into 1.04g/ml concentration, upper D101 macroporous resin column, after washing impurity with water, use the ethanol of 60% again, the speed of 3ml/min carries out eluting, collects eluent and is condensed into cream, dry, be ground into fine powder, obtain Herba Centellae extract.
3. antipruritic condensation as claimed in claim 1, is characterized in that the parts by weight of effective ingredient are as follows: Radix Sophorae Flavescentis extract 0.1-5 part, Aloe vulgaris leaf extract 0.1-5 part, Herba Centellae extract 0.1-5 part, menthol 0.01-1 part.
4. the antipruritic condensation as described in claim 1-3, is characterized in that the parts by weight of effective ingredient are as follows: Radix Sophorae Flavescentis extract 1 part, Aloe vulgaris leaf extract 2 parts, Herba Centellae extract 2 parts, menthol 0.15 part.
5., as the preparation method of the antipruritic condensation of claim 1-4 as described in any one, it is characterized in that comprising the following steps:
(1) by nano silicon SiO
2solid is distributed in redistilled water according to the ratio ultrasonic cell disintegration instrument of 1g:100mL, and after stirring 24h under 90 DEG C of conditions, centrifugalize product, and lyophilization, obtain the SiO activated
2; Again by the SiO of activation
2be distributed in redistilled water with ultrasonic cell disintegration instrument, then under high-speed stirred condition, drip 3-aminopropyl-triethoxysilane (APTES), APTES and (APTES+SiO
2) mol ratio be 1:4, and regulates the pH value of solution to be about 10, at 40 DEG C, stir 24h, centrifugalize product, and with redistilled water supersound washing product three times, lyophilization, obtains silane coupler modified SiO
2;
(2) get Radix Sophorae Flavescentis extract, Aloe vulgaris leaf extract, Herba Centellae extract and menthol 70% dissolve with ethanol solution, make the effective ingredient alcohol mixeding liquid of 20% concentration;
(3) by silane coupler modified SiO
2nanoparticle ultrasonic disperse is in redistilled water, and forming concentration is the dispersion liquid of 10mg/mL, and then adding quality is silane coupler modified SiO
2the effective ingredient alcohol mixeding liquid of nanoparticle 5%, 400rpm stirs 2h, allows effective ingredient and nanoparticle reach adsorption-desorption and balances; Under pH meter instruction, regulating the pH value of mixed liquor to being about 4.7 (when ie in solution is the most muddy), continuing to stir this mixed liquor 2h, centrifugalize product, and retain supernatant, use redistilled water centrifuge washing, last lyophilization, obtain the effective ingredient mixture of microencapsulation;
(4) the effective ingredient mixture of microencapsulation is added adjuvant, make condensation.
6. the preparation method of antipruritic condensation as claimed in claim 5, it is characterized in that the effective ingredient mixture of microencapsulation, the composition of adjuvant and weight proportion are: the effective ingredient mixture 60% of microencapsulation, carbomer 1%, propylene glycol 5%, ethanol 5%, sodium hydroxide 0.4%, diazolidinyl urea 0.0784%, iodine propilolic alcohol butyl mephenesin Carbamate 0.0016%, CI42090 pigment 0.001%, CI19140 pigment 0.0005%, water surplus, make condensation.
7. the preparation method of antipruritic condensation as claimed in claim 6, it is characterized in that making condensation by the following method: with propylene glycol, carbomer dispersion is even, add water, ethanol, the effective ingredient mixture of microencapsulation, diazolidinyl urea, iodine propilolic alcohol butyl mephenesin Carbamate, CI42090 pigment, CI19140 pigment successively, stir, until carbomer swelling evenly after regulate pH with sodium hydroxide, obtain antipruritic condensation.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853852A (en) * | 2016-04-15 | 2016-08-17 | 北京世纪鸿成商贸有限公司 | Gynecological lotion |
| CN105998552A (en) * | 2016-07-07 | 2016-10-12 | 无比滴（广东）药业有限公司 | Composition for relieving muscle discomfort and skin itchiness |
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| CN102120585A (en) * | 2011-01-26 | 2011-07-13 | 深圳航天科技创新研究院 | Preparation method of SiO2 micro-nanosphere and micro-reaction system |
| CN103463188A (en) * | 2013-09-27 | 2013-12-25 | 江门市新时代外用制剂有限公司 | Relieving itching condensation and preparing method thereof |
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2015
- 2015-08-31 CN CN201510547183.3A patent/CN105055803A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102120585A (en) * | 2011-01-26 | 2011-07-13 | 深圳航天科技创新研究院 | Preparation method of SiO2 micro-nanosphere and micro-reaction system |
| CN103463188A (en) * | 2013-09-27 | 2013-12-25 | 江门市新时代外用制剂有限公司 | Relieving itching condensation and preparing method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105853852A (en) * | 2016-04-15 | 2016-08-17 | 北京世纪鸿成商贸有限公司 | Gynecological lotion |
| CN105998552A (en) * | 2016-07-07 | 2016-10-12 | 无比滴（广东）药业有限公司 | Composition for relieving muscle discomfort and skin itchiness |
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