CN105044015B - The method of infrared spectrum pressed disc method test plug surface silicone oil - Google Patents
The method of infrared spectrum pressed disc method test plug surface silicone oil Download PDFInfo
- Publication number
- CN105044015B CN105044015B CN201510366520.9A CN201510366520A CN105044015B CN 105044015 B CN105044015 B CN 105044015B CN 201510366520 A CN201510366520 A CN 201510366520A CN 105044015 B CN105044015 B CN 105044015B
- Authority
- CN
- China
- Prior art keywords
- silicone oil
- sample
- infrared spectrum
- pressed disc
- extraction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Investigating Or Analysing Materials By Optical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of method of infrared spectrum pressed disc method test plug surface silicone oil, step is as follows：（1）Sample extraction：Plug is placed in dichloromethane, 5 ~ 10min of mechanical shaking extraction obtains extract solution, adds n-hexane and prepare the sample solution for obtaining that concentration is 0.06 ~ 0.25mg/mL；（2）Sample preparation：Take 50 μ L sample solution to be added to 0.3g KBrs surface, grinding obtains sample, weigh 0.075g and tabletting is made；（3）Detection：Tabletting is obtained into spectral line in scanning on FTIS, according to 1260cm on infrared spectrum‑1Peak height quantitatively calculate the content for obtaining silicone oil.The present invention determines the content of plug surface silicone oil using Fourier transform infrared spectroscopy pressed disc method, low to instrument requirements, and method is simple, invest small, and precision is high, is adapted to most of Medical Packing Materials industries, is a kind of bottle stopper surface silicone oil method of testing being worthy to be popularized.
Description
Technical field
The present invention relates to one kind medical packaging material --- butyl rubber plug surface silicon is tested using FTIS
The assay method of oil content.
Background technology
In recent years, the exceeded phenomenon in terms of butyl rubber pack bottle stopper clarity, is caused in industry to the compatible of bottle stopper
The concern of property.There are some researches show one of the reason for silicone oil on medicine bottle stopper surface is influence drug solution clarity.
Each plug manufacturer and major pharmacy corporations typically use silicone oil when cleaning plug at this stage.Silicone oil can be carried
The lubricity of high medicine bottle stopper, is conducive to smooth, the raising production efficiency of machine cabling on the bottle stopper of pharmaceutical factory；Silicone oil can reduce bottle
Frictional force between plug, reduces particulate and adhesion that bottle stopper produces in transportation etc..For parenterai administration
The silicone oil of packaging material, should reach certain quality control standard, while in terms of again can not be to Drug safety, quality
Impact.
Preferable state is, using silicone oil as few as possible, to reach that machine is smoothly required on lubricity and pharmaceutical factory, while again
Will not be to producing negative interaction in terms of safety of medicine, therefore be accomplished by quantitative determining the silicone oil for being attached to bottle stopper surface, together
When also to scene occur silication it is uneven the problems such as solution provide a kind of means.
The method of conventional measure silicone oil has：Atomic absorption spectrography (AAS), infra-red sepectrometry, gravimetric method etc..Infrared spectrum point
Analysis can not only be used for Qualitive test, and also have certain advantage at quantitative aspect.Also document report becomes using Fourier
Change Attenuated Total Reflect ion Infrared Spectroscopy and carry out quantitative test, have the disadvantage the ATR annexes for needing liquid, and it is expensive, it is unfavorable for
The popularization of Medical Packing Materials enterprise, many enterprises do not form effective investigation mechanism also, and only distinguish bottle stopper by straightforward procedure
The silicone oil amount on surface, this is to be grossly inaccurate.
The content of the invention
The purpose of the present invention is to measure butyl rubber plug surface silicone oil in 1260 cm using FTIS-1
Absworption peak, obtain the content of silicone oil with peak height method quantitative integration, this method is simple, quick, directly perceived so that Fourier's infrared light
Spectrum can more accurately measure silicone oil.
To achieve the above object, the present invention uses following technical scheme：
A kind of method of infrared spectrum pressed disc method test plug surface silicone oil, step is as follows：
（1）Sample extraction：Plug is placed in the container equipped with dichloromethane, 5 ~ 10min of mechanical shaking extraction obtains extract solution,
Dichloromethane in extract solution obtains silicone oil after being evaporated completely, and adds n-hexane into silicone oil, preparation obtain concentration for 0.06 ~
0.25mg/mL silicone oil sample solution；
（2）Sample preparation：Take 50 μ L silicone oil sample solution to be added to 0.3g KBrs surface, be placed in drying in 80 DEG C of baking ovens
1 ~ 2min, grinding makes silicone oil sample solution and KBr uniformly be mixed to get sample, and precise 0.075g samples, ingot processed is obtained
Tabletting；
（3）Detection：By step（2）Obtained tabletting obtains spectral line in scanning on FTIS, according to
1260cm on infrared spectrum-1Peak height quantitatively calculate the content for obtaining silicone oil.
The step（2）In ingot pressure processed be 10-20MPa, the time be 1 minute.
The step（2）In KBr dried 4 hours in 105 DEG C of drying baker using preceding, then in drier
Cooling.
The step（3）In FTIS resolution ratio be 4cm-1, scanning times are 16 times, wave number model
Enclose for 4000 cm-1~650cm-1。
The present invention is using n-hexane as solvent, and n-hexane does not have infrared absorption, without interference with the measure at quantitative peak, and
There is enough solubility to silicone oil, therefore using solvent of the n-hexane as silicone oil.
The present invention tests the assay method of plug surface silicone oil for FTIS pressed disc method, its
Middle FTIS is the WQF-510A type infrared spectrometers that Beijing Rayleigh Analytical Instrument Co., Ltd produces.
The present invention is using Extraction solvent or extractant of the dichloromethane as silicone oil, using the side of concussion extraction 5-10 minutes
Formula extract the silicone oil on plug surface.
First, the selection of quantitative peak and quantitative manner
It is documented that, the characteristic absorption peak of silicone oil mainly has (800 ± 10) cm-1、( 1020± 10) cm-1And
( 1260 ± 10) cm-13 peaks, therefore its characteristic peak is called W peaks, in (1260 ± 10) cm-1Absworption peak point and
By force, and not disturbed, easily integrated manually by other peaks, so 1260 cm of selection-1Peak is used as quantitative peak.
Infra-red sepectrometry quantitative manner is generally divided into peak height method and peak area method.Peak height and peak area can serve as quantitative
Integral way, thus the present invention contrasted for two kinds of quantitative manners, find out the best quantitative manner of correlation.Such as table 1 below,
Under the conditions of the silicone oil of same concentrations, integration obtains 1260 cm-1The peak height and peak area at place.
Under the same concentrations of table 1,1260 cm-1The peak height and peak area at place
The peak height and peak area obtained according to integration, draws the graticule equation of peak area and peak height, such as Fig. 1（Peak area mark
Line）And Fig. 2（Peak height graticule）.Contrast 1260 cm-1After the peak area and peak height of locating absworption peak, 1260 cm-1The peak height at place
Linearly dependent coefficient is higher, so using 1260 cm-1The peak height at place is used as quantitative integration mode.
2nd, the formulation of working curve and the investigation of accuracy
0.2136g scenes 350cst silicone oil is weighed, is dissolved in 100mL volumetric flasks, n-hexane constant volume is added, as right
According to product storing solution.Taking-up 3,5,8,10mL are inserted in 25mL volumetric flasks from reference substance storing solution, plus n-hexane is diluted to scale,
It is used as reference substance storing solution.Take 50 μ L to be added in 0.3g bromination potassium carriers respectively using microsyringe, be put into 80 DEG C of baking ovens
In 1 minute or so, take out grinding, accurate weighing 0.075g tablettings.Tableting pressure is kept 1 minute in the range of 10-20MPa.Adopt
It is 4cm with resolution ratio-1Scanning 16 times, wave-number range：4000~650cm-1.Scanned infrared spectrum, with 1260cm-1Peak height is quantified,
Peak area is returned with concentration, linear equation is：Y=0.125X+0.0042, R2=0.9998, as a result show, silicone oil is in concentration
It is linear good in the range of 0.06 ~ 0.25mg/mL.
Four reference substances of silicone oil, concentration is 0.1068 mg/mL, METHOD FOR CONTINUOUS DETERMINATION 5 times, quantitative 1260 cm-1Peak height.Determine number
According to such as table 2 below：
The concentration of table 2 is the peak height value of 0.1068 mg/mL solution
| Concentration | 1260 cm-1Peak height |
| 0.1068 mg/ml | 0.01661582 |
| 0.01707014 | |
| 0.01622640 | |
| 0.01627803 | |
| 0.01672900 |
According to following standard deviation equation, standard deviation S D is obtained, further according to standard deviation, relative standard deviation is obtained
RSD。
... ... ... ... ... standard deviation S D
... ... ... ... ... ... relative standard deviation RSD
Standard deviation S D=0.000346361, average=0.016583878, obtain RSD%=SD/ averages * 100%=
2.09%<5%, illustrate that the precision of the method is good.
3rd, the selection of extracting mode
To currently conventional several extracting methods：Refluxing extraction, mechanical shaking extraction and ultrasonic wave extraction are tested respectively.
Refluxing extraction is extracted using apparatus,Soxhlet's, and Extraction solvent is ether, and extraction time is 30min.Extract after solution cooling, revolving
Ether is removed, 1mL dichloromethane dissolving is then added, it is more to can be seen that the impurity that refluxing extraction comes out from dissolving situation,
The impurity for having partial white is not dissolved, and the extract solution that mechanical shaking extraction and ultrasonic wave extraction are obtained relatively is clarified, and impurity is less, and two
Chloromethanes dissolving is very fast.The infrared results measured after tabletting such as table 3 below：
The peak height value that the different extracting modes of table 3 are obtained
As can be seen from the above data, the peak height highest that mechanical shaking extraction is obtained, and impurity peaks are less, signal to noise ratio is minimum, and
The impurity of refluxing extraction is more, and infrared signal to noise ratio is higher, and mechanical shaking extraction and ultrasonic wave extraction can as can be seen from above
It is used as the method for extracting silicone oil.The present invention uses the silicone oil on mechanical shaking extraction plug surface.
4th, extraction or the selection of extractant
Understand that dichloromethane and n-hexane can serve as Extraction solvent or extractant and use according to experiment, but always
For body, selection dichloromethane is most suitable.Because dichloromethane boiling point is relatively low, readily volatilized, for many Medical Packing Materials enterprises,
Flat panel display is not all much rotated, selects this solvent to be still in normal temperature and is volatilized, or somewhat heats to accelerate examination
Process is tested, testing efficiency is so substantially increased.And n-hexane boiling point is 80.7 °C, the speed of normal temperature volatilization is very slow.Other two
The density ratio water of chloromethanes is big, easily layering, is highly suitable as the extractant of silicone oil.So in summary, selecting dichloromethane
It is used as the Extraction solvent or extractant of silicone oil.
The selection of solvent when the 5th, measuring
The present invention is using n-hexane as solvent, and n-hexane first does not have infrared absorption, so without interference with quantitative peak
Determine, while have enough dissolvings to silicone oil, therefore using solvent of the n-hexane as silicone oil during measurement.
Beneficial effects of the present invention：The present invention carries out pressed disc method using FTIS and determines plug surface
The content of silicone oil, low to instrument requirements, method is simple, invest small, and precision is high, is adapted to most of Medical Packing Materials industries, is a kind of
The bottle stopper surface silicone oil method of testing being worthy to be popularized.
Brief description of the drawings
Fig. 1 is silicone oil concentration of the present invention and 1260cm-1Peak area graticule figure, wherein 1260cm-1The graticule equation of peak area
Y=1.583X+0.1094, coefficient correlation is 0.9787.
Fig. 2 is silicone oil concentration of the present invention and 1260cm-1Peak height graticule figure, wherein 1260cm-1The graticule equation Y of peak height=
0.125X+0.0042, coefficient correlation is 0.9998.
Embodiment
Embodiment 1
The method of the infrared spectrum pressed disc method test plug surface silicone oil of the present embodiment, step is as follows：
（1）Sample extraction：Three samples of the medicinal halogenated butyl rubber plug that lot number is 1408320 are taken, each sample takes 8
Only, it is placed in the container equipped with dichloromethane, after the dichloromethane that mechanical shaking extraction 5min is obtained in extract solution, extract solution is evaporated completely
Silicone oil is obtained, n-hexane is added into silicone oil, the silicone oil sample solution for obtaining that concentration is 0.06mg/mL is prepared；
（2）Sample preparation：50 μ L silicone oil sample solution is taken to be added to 0.3g KBrs（KBr uses the preceding baking at 105 DEG C
Dry 4 hours, then cooled down in drier in dry case）Surface, is placed in 80 DEG C of baking ovens drying 1min, grinding makes silicone oil sample
Product solution and KBr are uniformly mixed to get sample, and precise 0.075g samples keep 1 under conditions of pressure is 10MPa
Minute, ingot processed obtained tabletting；
（3）Detection：By step（2）Obtained tabletting obtains spectral line, Fu Li in scanning on FTIS
Leaf transformation infrared spectrometer resolution ratio is 4cm-1, scanning times are 16 times, and wave-number range is 4000 cm-1~650cm-1, obtain red
1260cm on outer spectrogram-1Peak height, with regression equation calculation, obtain every square of plug surface silicone oil amount（μg/cm2）.
Embodiment 2
The method of the infrared spectrum pressed disc method test plug surface silicone oil of the present embodiment, step is as follows：
（1）Sample extraction：Three samples of the medicinal halogenated butyl rubber plug that lot number is 1409320 are taken, each sample takes 8
Only, it is placed in the container equipped with dichloromethane, the dichloromethane that mechanical shaking extraction 10min is obtained in extract solution, extract solution is evaporated completely
After obtain silicone oil, add n-hexane into silicone oil, prepare the silicone oil sample solution for obtaining that concentration is 0.25mg/mL；
（2）Sample preparation：50 μ L silicone oil sample solution is taken to be added to 0.3g KBrs（KBr uses the preceding baking at 105 DEG C
Dry 4 hours, then cooled down in drier in dry case）Surface, is placed in 80 DEG C of baking ovens drying 2min, grinding makes silicone oil sample
Product solution and KBr are uniformly mixed to get sample, and precise 0.075g samples keep 1 under conditions of pressure is 20MPa
Minute, ingot processed obtained tabletting；
（3）Detection：By step（2）Obtained tabletting obtains spectral line, Fu Li in scanning on FTIS
Leaf transformation infrared spectrometer resolution ratio is 4cm-1, scanning times are 16 times, and wave-number range is 4000 cm-1~650cm-1, obtain red
1260cm on outer spectrogram-1Peak height, with regression equation calculation, obtain every square of plug surface silicone oil amount（μg/cm2）.
Embodiment 3
The method of the infrared spectrum pressed disc method test plug surface silicone oil of the present embodiment, step is as follows：
（1）Sample extraction：Three samples of the medicinal halogenated butyl rubber plug that lot number is 1410320 are taken, each sample takes 8
Only, it is placed in the container equipped with dichloromethane, after the dichloromethane that mechanical shaking extraction 8min is obtained in extract solution, extract solution is evaporated completely
Silicone oil is obtained, n-hexane is added into silicone oil, the silicone oil sample solution for obtaining that concentration is 0.1mg/mL is prepared；
（2）Sample preparation：50 μ L silicone oil sample solution is taken to be added to 0.3g KBrs（KBr uses the preceding baking at 105 DEG C
Dry 4 hours, then cooled down in drier in dry case）Surface, is placed in 80 DEG C of baking ovens drying 1min, grinding makes silicone oil sample
Product solution and KBr are uniformly mixed to get sample, and precise 0.075g samples are protected under conditions of pressure is 10-20MPa
Hold 1 minute ingot processed and obtain tabletting；
（3）Detection：By step（2）Obtained tabletting obtains spectral line, Fu Li in scanning on FTIS
Leaf transformation infrared spectrometer resolution ratio is 4cm-1, scanning times are 16 times, and wave-number range is 4000 cm-1~650cm-1, obtain red
1260cm on outer spectrogram-1Peak height, with regression equation calculation, obtain every square of plug surface silicone oil amount（μg/cm2）.
Embodiment 4
The method of the infrared spectrum pressed disc method test plug surface silicone oil of the present embodiment, step is as follows：
（1）Sample extraction：Three samples of the medicinal halogenated butyl rubber plug that lot number is 1411320 are taken, each sample takes 8
Only, it is placed in the container equipped with dichloromethane, after the dichloromethane that mechanical shaking extraction 9min is obtained in extract solution, extract solution is evaporated completely
Silicone oil is obtained, n-hexane is added into silicone oil, the silicone oil sample solution for obtaining that concentration is 0.15mg/mL is prepared；
（2）Sample preparation：50 μ L silicone oil sample solution is taken to be added to 0.3g KBrs（KBr uses the preceding baking at 105 DEG C
Dry 4 hours, then cooled down in drier in dry case）Surface, is placed in 80 DEG C of baking ovens drying 2min, grinding makes silicone oil sample
Product solution and KBr are uniformly mixed to get sample, and precise 0.075g samples are protected under conditions of pressure is 10-20MPa
Hold 1 minute ingot processed and obtain tabletting；
（3）Detection：By step（2）Obtained tabletting obtains spectral line, Fu Li in scanning on FTIS
Leaf transformation infrared spectrometer resolution ratio is 4cm-1, scanning times are 16 times, and wave-number range is 4000 cm-1~650cm-1, obtain red
1260cm on outer spectrogram-1Peak height, with regression equation calculation, obtain every square of plug surface silicone oil amount（μg/cm2）.
Embodiment 5
The method of the infrared spectrum pressed disc method test plug surface silicone oil of the present embodiment, step is as follows：
（1）Sample extraction：Four samples of the medicinal halogenated butyl rubber plug that lot number is 1408328 are taken, each sample takes 8
Only, it is placed in the container equipped with dichloromethane, after the dichloromethane that mechanical shaking extraction 6min is obtained in extract solution, extract solution is evaporated completely
Silicone oil is obtained, n-hexane is added into silicone oil, the silicone oil sample solution for obtaining that concentration is 0.2mg/mL is prepared；
（2）Sample preparation：50 μ L silicone oil sample solution is taken to be added to 0.3g KBrs（KBr uses the preceding baking at 105 DEG C
Dry 4 hours, then cooled down in drier in dry case）Surface, is placed in 80 DEG C of baking ovens drying 1min, grinding makes silicone oil sample
Product solution and KBr are uniformly mixed to get sample, and precise 0.075g samples are protected under conditions of pressure is 10-20MPa
Hold 1 minute ingot processed and obtain tabletting；
（3）Detection：By step（2）Obtained tabletting obtains spectral line, Fu Li in scanning on FTIS
Leaf transformation infrared spectrometer resolution ratio is 4cm-1, scanning times are 16 times, and wave-number range is 4000 cm-1~650cm-1, obtain red
1260cm on outer spectrogram-1Peak height, with regression equation calculation, obtain every square of plug surface silicone oil amount（μg/cm2）.
As a result show, the different batches of embodiment 1 ~ 4 production medicinal halogenated butyl rubber bottle stopper surface silicon oil mass exist compared with
Big difference, and same batch（Embodiment 5）Inside difference is smaller.As shown in table 4 below and table 5：
The silicone oil of the different batches of products of table 4
| Lot number | 1260 cm-1Peak height | Every square of plug surface silicone oil amount（μg/cm2） |
| 1408320 | 0.03454882 | 9.71 |
| 1409320 | 0.02594745 | 6.96 |
| 1410320 | 0.02901328 | 7.94 |
| 1411320 | 0.03722617 | 8.46 |
The silicone oil of the same batch products of table 5
It was found from the measure of above sample（Table 4 and table 5）, there is larger difference in the silicone oil retention amount of different batches sample,
Silicone oil is more or less the same between same batch, this illustrates between different batches, the adhesive rate of silicone oil（Utilization rate）Difference
It is very big.
Note：Silicone oil in text is medical dimethyl silicone polymer class silicone oil, and the infrared spectrum pressed disc method that the present invention is provided is surveyed
The method of examination plug surface silicone oil is equally applicable to the measure of medical dimethyl silicone polymer series lubricant agent.
Embodiment described above is only that the preferred embodiment of the present invention is described, not to the model of the present invention
Enclose and be defined, on the premise of design spirit of the present invention is not departed from, technical side of the those of ordinary skill in the art to the present invention
In various modifications and improvement that case is made, the protection domain that claims of the present invention determination all should be fallen into.
Claims (2)
1. a kind of method of infrared spectrum pressed disc method test plug surface silicone oil, it is characterised in that step is as follows：
（1）Sample extraction：Plug is placed in the container equipped with dichloromethane, 5 ~ 10min of mechanical shaking extraction obtains extract solution, carries
Take the dichloromethane in liquid to obtain silicone oil after being evaporated completely, add n-hexane into silicone oil, preparation obtain concentration for 0.06 ~
0.25mg/mL silicone oil sample solution；
（2）Sample preparation：Take 50 μ L silicone oil sample solution to be added to 0.3g KBrs surface, be placed in 80 DEG C of baking ovens drying 1 ~
2min, grinding makes silicone oil sample solution and KBr uniformly be mixed to get sample, and precise 0.075g samples, ingot processed is obtained
Tabletting；
（3）Detection：By step（2）Obtained tabletting obtains spectral line in scanning on FTIS, according to infrared
1260cm on spectrogram-1Peak height quantitatively calculate the content for obtaining silicone oil；
The step（2）In ingot pressure processed be 10-20MPa, the time be 1 minute；
The step（2）In KBr dried 4 hours in 105 DEG C of drying baker using preceding, it is then cold in drier
But.
2. the method for the infrared spectrum pressed disc method test plug surface silicone oil according to claim 1, its feature exists
In：The step（3）In FTIS resolution ratio be 4cm-1, scanning times are 16 times, and wave-number range is
4000 cm-1~650cm-1。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510366520.9A CN105044015B (en) | 2015-06-29 | 2015-06-29 | The method of infrared spectrum pressed disc method test plug surface silicone oil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510366520.9A CN105044015B (en) | 2015-06-29 | 2015-06-29 | The method of infrared spectrum pressed disc method test plug surface silicone oil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105044015A CN105044015A (en) | 2015-11-11 |
| CN105044015B true CN105044015B (en) | 2017-08-18 |
Family
ID=54450733
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510366520.9A Active CN105044015B (en) | 2015-06-29 | 2015-06-29 | The method of infrared spectrum pressed disc method test plug surface silicone oil |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105044015B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105938078A (en) * | 2016-06-30 | 2016-09-14 | 全球能源互联网研究院 | Method for measuring organic solid content of anti-contamination flashover coating of auto-vulcanization silicone rubber |
| CN107063832A (en) * | 2017-05-23 | 2017-08-18 | 安徽中科中涣防务装备技术有限公司 | It is a kind of to be used for the on-line monitoring method of heavy metal concentration in electroplating sludge |
| CN108226085A (en) * | 2018-01-09 | 2018-06-29 | 广州伯朗氏检测技术有限公司 | The method that Fourier transform Attenuated Total Reflect ion Infrared Spectroscopy measures dimethicone the amount of migration in pre-encapsulated injector sub-assembly |
| CN110806391A (en) * | 2019-11-08 | 2020-02-18 | 湖北中烟工业有限责任公司 | Method for detecting oil stain on surface of dropping pill for cigarettes |
| CN110763647A (en) * | 2019-11-20 | 2020-02-07 | 蚌埠中光电科技有限公司 | Method for determining partition paper extract by using infrared spectroscopy |
| CN110823830A (en) * | 2019-12-16 | 2020-02-21 | 江南大学 | Method for quantitatively detecting silicone oil in daily chemicals by using infrared spectroscopy |
| CN114486606B (en) * | 2020-11-13 | 2024-06-25 | 中国石油天然气股份有限公司 | Method for measuring oil content |
| CN117969446A (en) * | 2024-02-01 | 2024-05-03 | 上海飞研检测技术有限公司 | Method for rapidly judging double bond content in polyethylene material |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101251479A (en) * | 2008-02-29 | 2008-08-27 | 中铝瑞闽铝板带有限公司 | Method for detecting oil content on foil surface of aluminum as well as aluminum alloy plate |
| CN104374630A (en) * | 2014-11-18 | 2015-02-25 | 中国石油天然气股份有限公司 | Detection pretreatment method for polycyclic aromatic hydrocarbon in oily sludge |
| CN104560377A (en) * | 2013-10-21 | 2015-04-29 | 大连市沙河口区中小微企业服务中心 | Method for extracting grease from fur |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005164402A (en) * | 2003-12-03 | 2005-06-23 | Eiichi Tashiro | Multi-faceted analysis method for oil content in soil |
-
2015
- 2015-06-29 CN CN201510366520.9A patent/CN105044015B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101251479A (en) * | 2008-02-29 | 2008-08-27 | 中铝瑞闽铝板带有限公司 | Method for detecting oil content on foil surface of aluminum as well as aluminum alloy plate |
| CN104560377A (en) * | 2013-10-21 | 2015-04-29 | 大连市沙河口区中小微企业服务中心 | Method for extracting grease from fur |
| CN104374630A (en) * | 2014-11-18 | 2015-02-25 | 中国石油天然气股份有限公司 | Detection pretreatment method for polycyclic aromatic hydrocarbon in oily sludge |
Non-Patent Citations (3)
| Title |
|---|
| 傅里叶变换红外光谱法测定甲基硅油;邓飞跃等;《广西化工》;20001231(第S1期);第1.1-2.3节 * |
| 王静芳等.溶剂萃取荧光分光光度法测定海水中微量油.《大连水产学院学报》.1987,(第02期),65-70页. * |
| 谢重阁.应用荧光分光光度法测定水中油的研究.《环境污染治理技术与设备》.1983,(第03期),9-14页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105044015A (en) | 2015-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105044015B (en) | The method of infrared spectrum pressed disc method test plug surface silicone oil | |
| Jamrógiewicz | Application of the near-infrared spectroscopy in the pharmaceutical technology | |
| Taylor et al. | Fourier transform Raman spectroscopic study of the interaction of water vapor with amorphous polymers | |
| Ma et al. | Characterization of pharmaceutical powder blends by NIR chemical imaging | |
| Li et al. | Application of near infrared spectroscopy for rapid analysis of intermediates of Tanreqing injection | |
| CN102288572A (en) | Method for quickly detecting content of index ingredient of traditional Chinese medicinal material by utilizing near infrared spectrum technique | |
| CN104165824B (en) | Automatic cone penetration analyzer | |
| CN103472025A (en) | Method for identifying quality of lignum pterocarri | |
| Flores et al. | Important issues in plant tissues analyses by HR‐MAS NMR | |
| CN104950052A (en) | Method for dementholized peppermint oil dropping pill quality detection by using gas chromatograph | |
| CN106018611A (en) | Testing method for detecting content of medium chain triglyceride with gas chromatography internal standard method | |
| CN102631440B (en) | External traditional Chinese medicine preparation for treating burns and scalds as well as preparation method and quality detection method of preparation | |
| Lai et al. | Application of a fluorescence sensor for miniscale on-line monitoring of powder mixing kinetics | |
| Kandpal et al. | Spectroscopic techniques for nondestructive quality inspection of pharmaceutical products: A Review | |
| Razvi et al. | Loss on drying using halogen moisture analyzer: An orthogonal technique for monitoring volatile content for in-process control samples during pharmaceutical manufacturing | |
| CN108007898A (en) | A kind of quickly L-Borneol medicinal material detection method | |
| Uchiyama et al. | Purity Determination of Cyclophosphamide Hydrate by Quantitative 31P-NMR and Method Validation | |
| CN102175629B (en) | Biological activity detection-based evaluation method of quality of prepared radix rehmanniae | |
| CN103196851A (en) | Measuring method of arsenic content of glyceryl triacetate | |
| Takeshima et al. | Analysis of the dehydration process of caffeine using backscattering and transmission Raman spectroscopy | |
| CN110736796B (en) | Method for detecting molecular weight of pneumococcal capsular polysaccharide | |
| CN105116061A (en) | Method for calculating contents of three effective components in curcuma longa product through relative correction factor | |
| CN108181259A (en) | The detection method and system of Radix Angelicae Sinensis sample | |
| Hisada et al. | Determining the distribution of active pharmaceutical ingredients in combination tablets using near IR and low-frequency Raman spectroscopy imaging | |
| CN107991420A (en) | The liquid phase chromatography analytical method of carbamazepine content in a kind of detection blood |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |