CN105031830B - Particle-beam therapeutic apparatus - Google Patents
Particle-beam therapeutic apparatus Download PDFInfo
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- CN105031830B CN105031830B CN201510305028.0A CN201510305028A CN105031830B CN 105031830 B CN105031830 B CN 105031830B CN 201510305028 A CN201510305028 A CN 201510305028A CN 105031830 B CN105031830 B CN 105031830B
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Abstract
It is a kind of by multiple therapeutic rooms while irradiating particle ray, so as to making the particle-beam therapeutic apparatus of multiple treatment patients it is an object of the invention to obtain.Including：Guide device (22) is breathed, which guides breathing based on target respiratory waveform (WIb)；Switching device (32), the switching device (32) switch the track of the particle beams；And irradiation unit (21), the irradiation unit (21) synchronously controls irradiation with target respiratory waveform (WIb), controller (4) synchronously controls the breathing guide device (22) and switching device (32) of multiple therapeutic rooms (6), cycle and phase of the controller (4) to the breathing guide device adjustment target respiratory waveform (WIb) of each therapeutic room (6), so that the irradiation time (TI) synchronous with the target respiratory waveform (WIb) of each therapeutic room (6) be not overlapping, and controller (4) also controls switching device (32), so that the track of the particle beams is switched according to the respective irradiation time (TI) of each therapeutic room (6).
Description
The application is that international filing date is " on September 9th, 2010 ", Application No. " 201080067834.4 ", entitled " particle
The divisional application of the application of beam therapeutic apparatus ".
Technical field
The present invention relates to the charged particle beam irradiation comprising the heavy particle ray such as proton radiation or carbon ray is arrived cancer etc.
Affected part is come the medical treatment device i.e. particle-beam therapeutic apparatus treated.
Background technology
Charged particle beam (the hereinafter referred to as particle beams) is irradiated to treatment target i.e. affected part by particle-beam therapeutic, to affected part
Tissue, which is given, to be destroyed to be treated, it is necessary to irradiate enough dosage to irradiation object i.e. affected tissue, and need to suppress to irradiate
To the dosage of surrounding tissue.Therefore, exposure dose, range of exposures is controlled (hereinafter referred to shine according to the shape of irradiation object
Launched field).For position, form with breathing changed irradiation object, breathing phases are measured, so that in place
Put, the breathing phases of form stable, the irradiation particle beams (for example, referring to patent document 1 and 2).
On the other hand, the equipment of beam offer source, that is, accelerator of particle-beam therapeutic is more huge, even if having in facility
There are multiple therapeutic rooms, generally can be also supplied to the particle beams respectively by switching the particle beam path exported by an accelerator
Therapeutic room.Therefore, in order to enable most of patients to receive treatment, and propose there is following particle-beam therapeutic apparatus, for example, to path
The control of switching electromagnet is made an effort, to shorten the particle-beam therapeutic apparatus of the time needed for toggle path (referring for example to special
Sharp document 3)；Guiding breathing is so that it is breathed according to the service cycle of accelerator etc., so as to shorten the particle for the treatment of time
Beam therapeutic apparatus (referring for example to patent document 4).
Prior art literature
Patent document
Patent document 1:Japanese Patent Laid-Open 2006-288875 publications ([0037]~[0040] section, Fig. 7~Fig. 9)
Patent document 2:International publication number WO2006/082651A1 ([0092~0096] section, Figure 16)
Patent document 3:Japanese Patent Laid-Open 2010-63725 publications ([0069] section, Fig. 3)
Patent document 4:International publication number WO2009/150708A1 ([0021]~[0026] section, Fig. 1, Fig. 6)
The content of the invention
The technical problems to be solved by the invention
However, either which kind of particle-beam therapeutic apparatus, the therapeutic room that can be treated in a period can only
It is the therapeutic room that path is set in multiple therapeutic rooms, and is only limitted to carry out treatment preparation in other treatment room, tidies up
Etc. stand-by operation etc..Therefore, i.e., enabled to shorten each process, the incrementss for the patient's number that can be treated are also limited.
The present invention is to complete to solve the above-mentioned problems, and its object is to can obtain one kind by the way that particle ray is existed
Multiple therapeutic rooms are irradiated in the same period, so as to making the particle-beam therapeutic apparatus of multiple treatment patients.
Technical scheme applied to solve the technical problem
The present invention particle-beam therapeutic apparatus be characterized in that, including：Multiple therapeutic rooms；The transport path of the particle beams,
Accelerator is connected by the transport path of the particle beams with each therapeutic room of above-mentioned multiple therapeutic rooms；Switching device, switching dress
Put and be arranged in above-mentioned transport path, switch the track of the above-mentioned particle beams so that the particle beams projected from above-mentioned accelerator is provided
To any one therapeutic room in above-mentioned multiple therapeutic rooms；Guide device is breathed, which is arranged at above-mentioned multiple
In each therapeutic room of therapeutic room, the breathing of patient is guided based on target respiratory waveform；Irradiation unit, the irradiation unit are arranged at
In each therapeutic room of above-mentioned multiple therapeutic rooms, the particle beams provided is formed to correspond to the irradiation field of irradiation object, and extremely
It is few synchronously to control the irradiation carried out to above-mentioned irradiation object with above-mentioned target respiratory waveform；And controller, the control
Breathing guide device in the therapeutic room of more than two specified quantities in the above-mentioned multiple therapeutic rooms of device at least Synchronization Control with
Above-mentioned switching device, controller noted above adjust cycle and the phase of above-mentioned target respiratory waveform, so that above-mentioned specified quantity
Therapeutic room, synchronous with above-mentioned target respiratory waveform irradiation time non-overlapping, and controller noted above also controls above-mentioned cut
The switching instant of the beam trajectory of changing device, so that the above-mentioned irradiation according to each therapeutic room of the therapeutic room of above-mentioned specified quantity
Time correspondingly switches the track of the above-mentioned particle beams.
Invention effect
Particle-beam therapeutic apparatus according to the present invention, can divide the particle beams provided by accelerator within the respiratory cycle
When mode be irradiated to multiple therapeutic rooms, so as at the same time by particle-beam exposure to multiple therapeutic rooms.Accordingly, it is capable to obtain a kind of energy
Make the particle-beam therapeutic apparatus of multiple treatment patients.
Brief description of the drawings
Fig. 1 is the integrally-built figure for illustrating the particle-beam therapeutic apparatus of embodiments of the present invention 1.
Fig. 2 is the work(for illustrating the structure of the control system of the particle-beam therapeutic apparatus of embodiments of the present invention 1
Can block diagram.
Fig. 3 is the multiple therapeutic rooms and delivery system for illustrating the particle-beam therapeutic apparatus of embodiments of the present invention 1
The sequence diagram of the coordination control of system.
Fig. 4 is the flow chart for illustrating the action of the particle-beam therapeutic apparatus of embodiments of the present invention 1.
Fig. 5 is the flow chart for illustrating the action of the particle-beam therapeutic apparatus of embodiments of the present invention 2.
Embodiment
Embodiment 1
In the following, the structure of the particle-beam therapeutic apparatus of explanation embodiments of the present invention 1.Fig. 1 to Fig. 4 is used to illustrate this
The structure of the particle-beam therapeutic apparatus of the embodiment 1 of invention, Fig. 1 are the figures for the structure for representing particle-beam therapeutic apparatus,
Fig. 2 is that Fig. 3 is to represent that particle ray is controlled for illustrating the functional block diagram with the relevant structure of control of particle-beam therapeutic apparatus
The figure of the control sequential of breathing navigation and transport system in treatment device, each therapeutic room.In addition, Fig. 4 is to be used to illustrate particle
The flow chart of the action of beam therapeutic apparatus.
First, the general configuration of particle-beam therapeutic apparatus is illustrated using Fig. 1.In Fig. 1, particle-beam therapeutic dress
Put including：Synchrotron, that is, the circular accelerator 1 (hereinafter referred to as accelerator) in source is provided as charged particle beam；Including setting
Put the irradiation system 2 of the irradiation unit in each therapeutic room；Accelerator 1 is connected with each therapeutic room, by charged particle beam from
Accelerator is delivered to the transport system 3 of the irradiation unit of each therapeutic room；And coordinate to control these systems (hereinafter referred to as subsystems
System) control system 4.Moreover, the feature structure of the particle-beam therapeutic apparatus of embodiments of the present invention is, make each treatment
The phase controlling of breathing guiding of the irradiation unit of room and the path of the irradiation unit of other treatment room and transport system switch phase
It is synchronous.Illustrate each structure first, describe in detail utilize the coordination synchronously realized afterwards.
＜ accelerators ＞
Accelerator 1 includes：The vacuum pipe 11 of rotating orbital path is carried out as charged particle beam；For will be by prime
The charged particle that accelerator 5 provides incides the incidence mount 12 in vacuum pipe 11；Form charged particle trajectory deflection
Deflection electromagnet 13a, 13b, 13c, the 13d of charged particle along the rotating charged particle beam of swing-around trajectory in vacuum track 11
(being referred to as 13)；Make to be formed at charged particle on swing-around trajectory assemble with prevent convergence electromagnet 14a, 14b that it dissipates,
14c, 14d (are referred to as 14)；Make the high frequency that it accelerates to carrying out the synchronous high frequency voltage of rotating charged particle application
Accelerating cavity 15；It is outer and to conveying that charged particle beam for that will carry out accelerating in accelerator 1 and obtain is fetched into accelerator 1
The ejecting device 16 that system 3 projects；And in order to make charged particle beam be projected from ejecting device 16 and to the rotation of charged particle
Track carries out the sextupole electromagnet 17 of resonance excitation.
In addition, the device (not shown) for being controlled to each several part is further included, such as：Deflect electromagnet 13 include pair
The deflection electromagnet control device that the exciting current of deflection electromagnet 13 is controlled；Radio-frequency acceleration cavity 15 includes being used for high frequency
Accelerating cavity 15 provides the high frequency source of high frequency voltage and the high audio-frequency control device for controlling high frequency source；Include in control unit 4
Deflection electromagnet control device, high audio-frequency control device, convergence are controlled to control entirely with other parts such as electromagnet 14
The Accelerator control device 41 of accelerator 1.However, in the technical concept of the present invention, do not limit to the control of of accelerator 1 itself
System, therefore said structure is not limited to, and in the nature of things, transport system is injected to as long as charged particle beam can be stablized
3 various modifications example, is all allowed.
In addition, to simplify purpose, recorded in figure using prime accelerator 5 as an equipment, but it is in fact, preceding
Level accelerator 5 include producing the ion guns (ion beam generation mechanism) of the charged particles (ion) such as proton, carbon (heavy particle) with
And the linear accelerator system of initial acceleration is carried out to caused charged particle.Moreover, incide acceleration from prime accelerator 5
The charged particle of device 1 can be accelerated by high-frequency electric field, and while make its bending using magnet, be accelerated to the 70% of the about light velocity
~80%.
＜ transport systems ＞
Charged particle beam after being accelerated by accelerator 1 is radiated into referred to as HEBT, and (high energy beam conveys：High Energy
Beam Transport) system transport system 3 in.Transport system 3 includes：As the vacuum of the transport path of charged particle beam
Main pipeline 31m, therapeutic room A (are referred to as vacuum pipe 31) by pipeline with pipeline 31A and therapeutic room B with pipeline 31B；To powered
The switching device that the beam trajectory of the particle beams switches over switches electromagnet 32；And make beam deflection for the inclined of predetermined angular
Turn electromagnet 33.Then, utilize as needed switch electromagnet 32 change by accelerator 1 provide abundant energy and by
The track (31A directions, 31B directions) of the charged particle beam to advance in the transport path that vacuum pipe 31 is formed, is directed to set
The irradiation unit being placed in designated treatment room.
＜ irradiation systems ＞
Irradiation system 2 includes：The charged particle beam provided by transport system 3 is formed as and irradiation object i.e. patient's affected part
Size, the corresponding irradiation field of depth irradiate the irradiation unit 21 of affected part；And guided with the breathing being referred to as when irradiating,
Breathe the navigation feature portion 22 of navigation feature.Then, at least navigate with breathing linkedly, according to the mesh used in breathing navigation
The phase in the cycle of respiratory waveform is marked, to control ON/OFF to be irradiated irradiation object i.e. affected part.In addition, such as defeated
Send system illustrate in " being arranged at irradiation unit in designated treatment room " it is described like that, from the viewpoint of therapeutic efficiency,
It (is 6A, 6B in figure that particle-beam therapeutic apparatus, which generally comprises multiple therapeutic rooms,.It is referred to as therapeutic room 6).That is, for shown here
Irradiation system 2, irradiation unit 21 and navigation feature portion 22 are equipped with each therapeutic room 6, for example, the irradiation of therapeutic room 6A
System 2A includes irradiation unit 21A and navigation feature portion 22A.
In order to realize breathing navigation feature, navigation feature portion 22 includes：The patient of breathing state for measuring patient exhales
Inhale measurement device 22a；The breathing that particle ray is irradiated to patient is allowed based on the measure information of patient respiratory measurement device 22a
Sychronisation 22c；And for the respiration information guiding device 22b to patient education and the relevant information of synchronized with breath.
＜ control systems ＞
Control system for the large complicated system being made of like this multiple subsystems, generally, mostly by right
The sub-controller and formed to the overall master controller for carrying out command and control that subsystems are specially controlled.In the present invention
Embodiment 1 particle-beam therapeutic apparatus control system 4 in, also using the structure of the master controller and sub-controller.
For the sake of simplicity, in the control system of particle-beam therapeutic apparatus with accelerator 1, transport system 3, irradiation system 2 these three
Subsystem controls related control system, i.e. as shown in the figure, including Accelerator control portion 41, transport system control unit 43, shining
The control system 4 for penetrating systems control division 42 and overall control unit 40 illustrates.
Using the Fig. 2 for schematically showing Control system architecture, control system 4 is illustrated.In addition, controlled in particle ray
In the controller for treating device, generally using work station, computer.Therefore, also controller is known as " computer " in many cases.
For example, the master controller 40 in Fig. 2 is actually the function on computer, and it is public to be referred to as irradiation system as a rule
Computer, but treated herein as the controller with certain.In addition, equipment control computer is equivalent to subsystem
System is the sub-controller 42 that irradiation system 2 is controlled, and by corresponding to the irradiation system being distributed in each therapeutic room 6A, 6B
The appropriate section of the controller of system 2A, 2B is distinguished as 42A, 42B.Thus, in the control system of particle-beam therapeutic apparatus (system)
In system 4, including：Master controller 40；And the controller of accelerator 1, the controller of irradiation system 2, transport system 3 control
Device, i.e. sub-controller 41,42,43.Also, each sub-controller 41,42,43 is indicated by the timing being arranged in master controller 40
Function coordinates to be controlled action.In addition, timing instruction function in itself also can as described in such as patent document 3,
Output is used for the timing signal synchronized.In addition, in fig. 1 and 2, position of sub-controller etc. exist it is different, this be because
For, in Fig. 1, controller 4 is uniformly recited as, and be described on the basis of control object in fig. 2, therefore, not
Whether different represent its physical location.That is, as controller, physically how to configure not is essential problem.
" operation console " being connected with equipment control computer (sub-controller 42A, 42B) is so-called keyboard, display etc.,
The either terminal, i.e. human-machine interface oral area such as control cabinet.Operation console is arranged on therapeutic room 6 and the photograph being provided separately mostly with therapeutic room
Penetrate in operating room.Control panel is linked with the next stage of equipment control computer.Specifically, as described in bracket, control panel
It is driver, amplifier and PLC (the Programmable Logic Controller of the i.e. various equipment of control object：It is programmable
Logic controller) etc..Via being linked with equipment on the further next stage of control panel.Equipment includes being used for each axis for making instrument table
Motor of X-ray image-pickup device in mobile motor, driving irradiation unit etc., in general, above-mentioned irradiation unit 21, navigation
Functional device 22 is also included.
However, it is recorded into the particle-beam therapeutic apparatus of present embodiment 1, for related with navigation feature portion 22
Control, not via the control panel being arranged in each therapeutic room 6, but is directly controlled by master controller 40.The reason is that
As described below, in the particle-beam therapeutic apparatus of present embodiment 1, not independently controlled in a therapeutic room
Breathing navigation, and need mutually to control it in phase with other treatment room and transport system, therefore, by further reducing
Via equipment, so as to avoid causing because producing dead time (delay) periodically that there is a situation where deviation.However, might not
To be directly connected to like this, in the nature of things, as long as can ensure that sequential, appropriate change can also be carried out.
Other effects of navigation feature portion irradiation system public computer (master controller 40) include：Refer to as described above
Wave whole particle-beam therapeutic apparatus；As the equipment for needing synchronously to be controlled with accelerator system 1, transport system 3
Controller, itself undertakes the function of sub-controller 42.This be also why in Fig. 1 by 42 notes in bracket.
Thus, control function related with breathing guide device 22 in sub-controller 42 is undertaken by master controller 40.It is right
In it is other for example for each axis of instrument table move motor, drive the electricity of X-ray image-pickup device in irradiation unit
The equipment such as motivation, are usually controlled via sub-controller 42.These instrument table motor, X-ray image-pickup device are with electronic
Machine will not move during beam exposure.That is, this is because they need not be with the control of accelerator system 1, transport system 3
Synchronizedly it is controlled.In order to notify state to each other, in irradiation system public computer (master controller 40) and irradiation
Following signal is exchanged between the equipment control computer (sub-controller 42) of system：Representing the irradiation system 2 of which therapeutic room 6 is
Complete and positioned and in Ready (ready) signal for the state that can be irradiated；The irradiation system of which therapeutic room 6 informed
System 2 has irradiated beam and has completed signal of irradiation etc..In simple terms, the meaning of sequential affair is exactly carried out.That is, irradiation system
Effect of the public computer (master controller 40) in the association with sub-controller 42 is to compare to penetrate to be managed, such as " which
The irradiation system 2 of therapeutic room 6 fights for the beam from accelerator ", once making decision to this, can just determine afterwards every
Order among the sub-controller 42 of a therapeutic room 6.
However, as will be described later, it is necessary to Synchronization Control in the particle-beam therapeutic apparatus of embodiments of the present invention 1
Breathing, the beam switching of each therapeutic room.I.e., it is impossible to order is only determined by the sub-controller of each therapeutic room.Therefore, it is not
Command value is sent to navigation feature portion 22 by equipment control computer (sub-controller 42), but directly by command value from photograph
Penetrate system public computer (master controller 40) and be sent to navigation feature portion 22.
In addition, the function of the formation irradiation field in the function of irradiation system 2 is not the essential part of the present invention.Therefore,
Omit the description to 21 structure of irradiation unit.On the other hand, irradiation object is carried out to control for being connected with breathing navigation
The beam gating (beam gate) of the ON/OFF of irradiation is, it is necessary to synchronous with transport system 3, therefore, although being not marked in Fig. 2
In, but beam gating is directly controlled by master controller 40.In addition, it is desirable to waved with what accelerator system 1 was synchronously controlled
Although the equipment of electromagnet or scanning electro-magnet etc. and irradiation unit 21, the reasons why identical is based on, it is public by irradiation system
Computer 40 is directly controlled altogether.
Then, illustrated using Fig. 3 in the particle-beam therapeutic apparatus of embodiments of the present invention 1, at timesharing
The mode of the reason particle beams that irradiation is provided by accelerator at the same time in multiple therapeutic rooms, and navigate to breathing and carry out coordination control
The method of system.Respectively, breathing navigation waveform WIb (A), the breathing navigation waveform in therapeutic room 6A are shown on the top of Fig. 3
The ON/OFF signal BG (A) of threshold value Th (A) and the beam gating (beam gate) of WIb (A), shows in the middle part of Fig. 3
The threshold value Th (B) and beam gating (beam of breathing navigation waveform WIb (B), breathing navigation waveform WIb (B) in therapeutic room 6B
Gate ON/OFF signal BG (B)), BL represent datum line.The lower part of Fig. 3 represents beam switching electromagnet in transport system 3
32 beam trajectories switched (path).Moreover, the transverse axis in Fig. 3 represents timing corresponding with the respiratory cycle for several times, it is whole to Fig. 3
Body is general (synchronization), and the timing in future is then more represented closer to right side.(WIb (A) and WIb (B) is united for breathing navigation waveform
Referred to as WIb, by Th (A) and Th (B) be referred to as Th) situation, the longitudinal axis represents breathing state, is suction condition upward, downwards
Side is expiration state.In the case of ON/OFF signal (BG (A) and BG (B) are referred to as BG) of beam gating, the longitudinal axis
Upside represents conducting state, and downside represents off-state, and in the case of track, the upside of the longitudinal axis represents setting track (path)
It is set to represent that setting track (path) makes it towards therapeutic room 6B towards therapeutic room 6A, the downside of the longitudinal axis.
In addition, in the respiration information guiding device 22b of each therapeutic room 6 is arranged at, with time going by, from dextrad
Dynamic mode roll left to show the navigation waveform in figure (target respiratory waveform), patient is according to the target respiratory waveform of the rolling
Show to navigate to breathing.At this time, the laser for the abdominal exercise for for example measuring patient is used in respiration measuring device 22a
In the case of displacement meter etc., if the unit of display of the longitudinal axis to be set to the output quantity of laser displacement gauge, by making target respiratory wave
Shape is overlapped with actual measured value to be shown, the offset for visually showing and navigating to patient so as to one side, and one
While navigate to breathing.
In general, the affected part internal organ of patient, most stable of position is at expiration state (lower section of the longitudinal axis), because
This, position, shape based on the irradiation object under expiration state carry out treatment plan, can also be penetrated under expiration state
Beam irradiates.Threshold value Th in figure represents a reference value for allowing beam exposure.Respiration gated signal BG represents target respiratory waveform WIb
Turned on during less than threshold value Th.In the treatment, target respiratory waveform and the waveform (not shown) for representing actual breathing state this two
Allow to be irradiated when person reaches below threshold value.Herein, Synchronization Control, then omission represent real in relation to being based on for the purpose of simplifying the description
The explanation of the control of the waveform of border breathing state.
Herein, switch for the path of transport system, existing situation is, as long as a therapeutic room starts to treat, then directly
Untill the treatment end, path is switched into other treatment room all without in midway, will not be as shown in the lower part of Figure 3 like that one
The path of switching transport system in a respiratory cycle.That is, could be to other trouble until terminating after being irradiated to a patient
Person is irradiated.In the particle-beam therapeutic apparatus of present embodiment, due to sharing the band provided by accelerator 1 in time
Electrochondria beamlet, therefore, it is impossible to simultaneously turn on respiration gated in therapeutic room 6A and therapeutic room 6B.However, present embodiment
In particle-beam therapeutic apparatus, between therapeutic room 6A and therapeutic room 6B, can repeatedly it switch in once irradiating is carried out (with breathing
Cycle is unit) path, so as to irradiate the particle beams at the same time to multiple patients in the same period, i.e. multiple patients can be made same
When receive particle-beam therapeutic.Next, describe its implementation in detail.
Generally, the respiratory cycle of the mankind is not constant, and its length also varies with each individual.However, breathing can be utilized
Guider etc. guides so that it is breathed by certain cycle.The reason is that although breathing is by autonomic nerve institute
Dominate, but also exceptionally can dominate action by realizing.Therefore, in patent document 4, with what is be adapted with the accelerator cycle
Cycle carries out breathing navigation.Simply even in this case, will not be in during a therapeutic room is irradiated
Other treatment is irradiated in room.Therefore, in the particle-beam therapeutic apparatus of embodiments of the present invention, in therapeutic room 6A and control
Treat in the 6B of room, by making cycle that target breathes consistent and dephase ormal weight, and prescribed phases in the cycle are cut
Charged particle beam of changing commanders is transported to the transport path of therapeutic room 6A and 6B, so as at the same time in therapeutic room 6A and 6B
Middle carry out particle-beam therapeutic.For the cycle, average respiratory cycle i.e. 2 second of people can be set to during 20 seconds, and can adjust
Whole phase offset so that the respiration gated in therapeutic room 6A and therapeutic room 6B will not simultaneously turn on (ON).Referring next to Fig. 4's
Flow chart illustrates.
Cycle set by target breathing is while cycle (step S10) for being adapted to of patient receiving treatment.If it will set
Fixed periodical input determines the phase (offset) of each therapeutic room to master controller 40, then master controller 40, after calculating and deviating
The corresponding transport system 3 of phase path switching timing TC (step S20).Then, the timing being built in master controller 40
Indicator carries out following instruction.Breathing guider 22A, 22B instruction phase of the timing indicator to each therapeutic room 6A, 6B has partially
Move target breathing timing.Then, timing indicator to path switching device (in Fig. 1 switching electromagnet 32 control device or
Sub-controller 43) instruction timing so that it is irradiated in the respiration gated conducting of therapeutic room A in A rooms, in exhaling for therapeutic room B
It is irradiated (step S30) in B rooms when inhaling gating conducting.Thus, then can be such as Fig. 3 institutes as long as each therapeutic room is ready
Show like that, be carried out at the same time the irradiation particle beams (step S40) in the same period in therapeutic room 6A and therapeutic room 6B.
In addition, at this time in Liang Ge therapeutic rooms, without starting simultaneously at irradiation by force, and each therapeutic room can be directed to and determine to shine
Penetrate beginning and irradiation terminates.But for the treatment in each therapeutic room, if only being carried out in the part of the prescribed phases of breathing navigation
Irradiation, then the period being irradiated in multiple therapeutic rooms (6A, 6B) is overlapping, also can such as in single therapeutic room into
Row treatment performs the treatment in each therapeutic room like that, its reason is can be within the respiratory cycle to the particle from accelerator 1
Shu Jinhang time-division processings.
For the timing TC of path switching, in figure 3, such as path is switched to the timing of therapeutic room 6B from therapeutic room 6A
It is set to TCAB, the gating of therapeutic room 6A is switched to the timing of disconnection (OFF) from conducting (ON) and is set to TfA, by the choosing of therapeutic room 6B
The logical timing that conducting is switched to from disconnection is set to ToB, in addition, although not shown, but path is switched to from therapeutic room 6B and is controlled
The timing for treating room 6A is set to TCBA, the gating of therapeutic room 6B is switched to the timing of disconnection from conducting and is set to TfB, by therapeutic room 6A
Gating be switched to the timing of conducting and be set to To from disconnectingA, then preferred following formula (1) and formula (2) are set up.
TCAB- TfA＜ ToB- TCAB···(1)
TCBA- TfB＜ ToA- TCBA···(2)
The reason is that in the time PC that all disconnects of gating of the both sides of Liang Ge therapeutic roomsAB(=ToB- TfA), PCBA(=
ToA- TfB) in, make " since toggle path to gating conducting time " be longer than " and since disconnect to toggle path when
Between ", so that when switching electromagnet 32 in the path for operating transport system 3, it can ensure that acquisition is steady to track since toggle path
Time between being set to only.
Then, the method for illustrating to generate target respiratory waveform.Although the manually generated target respiratory waveform of energy, most natural
Be that target respiratory waveform is generated according to the situation of patient itself.Display target respiratory waveform simultaneously makes the breathing mesh consistent with its
Be, in plan and during treatment, reproduce the identical posture of affected part.Therefore, it is possible to patient is first allowed to loosen
Breathed under posture, be measured with respiration measuring device 22a.Then, the respiratory waveform measured is finely adjusted, when
Between increase shorten, equalization etc., come set for make the cycle phase of therapeutic room 6A and therapeutic room 6B with the appropriate cycle.This
When, also can be based on being stored in the case of the general breathing waveform that patient is stored with therapy planning device (not shown)
Waveform calculates the most suitable target respiratory cycle.In addition, in selected patient receiving treatment at the same time, can also select automatically certainly
Patient similar in the right respiratory cycle, i.e. easily make the patient that the cycle is consistent.
In addition, in the above description, although being adjusted to Liang Ge therapeutic rooms so that cycle phase is same and inclined there occurs phase
Move, but in addition to that can also be set as situations below, such as the relation that can also make the cycle that there is integral multiple, and be adjusted and make
Irradiation time does not overlap each other, therefore, however it is not limited to there is the identical cycle, as long as can make by adjusting cycle and phase
Irradiation time is not overlapping.
As described above, 1 particle-beam therapeutic apparatus according to the present embodiment, including：Multiple therapeutic rooms 6；Navigation feature
Portion 22, the navigation feature portion 22 be arranged at each therapeutic room of multiple therapeutic rooms 6, is guided based on target respiratory waveform WIb
The breathing guide device of the breathing of patient；The transport path 31 of the particle beams, the transport path 31 of the particle beams is by accelerator 1 and more
Each therapeutic room of a therapeutic room 6 is connected；Switch electromagnet 32, which is arranged in transport path 31, is
The track of the switching particle beams causes any one treatment being provided to from the particle beams that accelerator 1 projects in multiple therapeutic rooms 6
The switching device of room；Irradiation unit 21, the irradiation unit 21 are arranged in each therapeutic room of multiple therapeutic rooms 6, will be provided
The particle beams be formed as irradiation field corresponding with irradiation object, and at least synchronously compareed with target respiratory waveform WIb to control
Penetrate the irradiation of object progress；And controller 4, the two or more in the above-mentioned multiple therapeutic rooms 6 of at least Synchronization Control of controller 4
Specified quantity therapeutic room 6A, 6B breathing guide device 22 and switching electromagnet 32, controller 4 is configured to specified quantity
Therapeutic room breathing guide device 22 adjust target respiratory waveform WIb (A), WIb (B) cycle and phase so that with rule
Irradiation time (TI (A) and TI (B)) non-overlapping of the target respiratory waveform WIb synchronizations of therapeutic room 6A, 6B of fixed number amount, and
Controller 4 also controls the switching instant TC of switching electromagnet 32AB, so that each therapeutic room of the therapeutic room of quantity according to the rules
Irradiation time (TI (A) and TI (B)) correspondingly switches the track of the particle beams, accordingly, it is capable in the respiratory cycle, in multiple treatments
The particle beams projected by accelerator 1 provided in room with time-sharing format receiving, to irradiate the particle beams at the same time.Accordingly, it is capable to obtain
Particle-beam exposure is carried out in multiple therapeutic rooms at the same time, makes the particle ray of multidigit treatment patients
Therapeutic system.
Especially, the breathing guide device that controller 4 is configured to the therapeutic room of specified quantity is adjusted, so that generation
Cycle phase with and the target respiratory waveform that shifts of phase, accordingly, it is capable to easily be adjusted, so that irradiation time is mutual
It is not overlapping.
Especially, control room 4 is configured to switch track from the first therapeutic room (such as 6A) in the therapeutic room of specified quantity
Track switching instant to the second therapeutic room (such as 6B) is set to TC12, the irradiation of the first therapeutic room 6A is switched to from conducting disconnected
Open and stop being set to Tf at the time of irradiation1, by the irradiation of the second therapeutic room 6B since disconnect be switched to conducting i.e. irradiation when
Quarter is set to To2, then switching instant is controlled to cause [TC12- Tf1＜ To2- TC12] set up, therefore, on the road of operation transport system 3
When footpath switches electromagnet 32, the time untill playing orbitally stable from toggle path (track) is elongated, the irradiation that can be stablized.
Embodiment 2.
In embodiment 1, the situation that therapeutic room is two is illustrated.But, it is however generally that, in most cases
One main accelerator 1 of particle-beam therapeutic apparatus corresponds to three to four therapeutic rooms.Therefore, in present embodiment 2, to treatment
Room is that the situation of more than three illustrates.
Term in following term and above formula embodiment 1 be it is shared, still, the phase in multiple therapeutic rooms are illustrated
During offset, definition can be re-started to several terms.
<Respiratory cycle>
As shown in figure 3, target respiratory waveform is made of the waveform for being repeated cyclically identical patterns.For example, every a timing
Between interval occur represent the most air conditions of inspiration maximum.The intervals are known as " respiratory cycle " (C (A)
Or C (B), it is referred to as C) (unit is the time [sec (second)]).
<Breathing phases>
As shown in figure 3, target respiratory waveform WIb (A) and target respiratory waveform WIb (B) has identical respiratory cycle C,
But the position of the maximum of target respiratory waveform WIb (A) and target respiratory waveform WIb (B) is offset from each other.Thus, two will be made
The offset that a same waveform produces in time when overlapping is known as " phase offset ".Can according to consider trigonometric function (sine,
Identical mode considers the phase offset when cosine).Thus, the unit of phase is radian or degree (°).
<Duty cycle (duty ratio)>
As shown in figure 3, respiration gated signal BG can be determined according to target respiratory waveform WIb.In embodiment 1, say
Understand the method for turning on gating signal BG when target breathing WIb is less than threshold value Th.Thus, respiration gated signal BG is to repeat
PWM (the Pulse Width Modulation of conducting and disconnection binary signal through width (time) adjustment：Pulsewidth modulation) letter
Number.The ratio between the ON time of respiration gated signal and turn-off time can be represented with duty cycle.Specifically, duty cycle is determined
Justice is the ON time of signal relative to the ratio of integral cycle.For example, it is 1 in the time ratio for turning on and disconnecting：3 situation
Under, duty cycle is 0.25 (=1/ (1+3)).
Now, it is assumed that the duty cycle of respiration gated signal BG is 0.5 (1/2), and repeats ON/OFF.In such case
Under, if dephasing 180 degree, gating signal BG that can be in Shi Liangge therapeutic rooms will not be simultaneously turned on.That is, in the above situation
Under, at most beam exposure can only be carried out at the same time with time-sharing format in the Liang Ge therapeutic rooms.It is desirable that it is 0.5 in duty cycle
When, irradiation can be carried out at the same time with time-sharing format in Liang Ge therapeutic rooms.However, actually also need to consider that the path of therapeutic room is cut
Change the time, therefore, also have other limitations.
On the other hand, if considering the relation between the breathing of patient and the posture of affected part internal organ, there are following feelings
Condition.Threshold value Th is lower, then can reproduce the posture of affected part goodly.On the other hand, if reducing threshold value Th, respiration gated letter
Number duty cycle also accordingly reduce.
The time-sharing method in the case that number of chambers amount is more than 3 is treated using Mingzhi for the flow chart of Fig. 5.It is right as premise
It should be slightly less than for 0.5 (being slightly less than 1/2) in the duty cycle of the respiration gated signal BG of target breath signal WIb, can be in the same time
Liang Ge therapeutic rooms are irradiated in section, but three therapeutic rooms can not be irradiated in the same period, i.e. can cause to deposit
In the time equitant therapeutic room for turning on irradiation.Then, as target respiratory waveform WIb, preparing phase, there occurs 180 degree
The waveform WIb (α) and waveform WIb (β) of offset the two timing group α, β (step S210).
First, the doctor for the treatment of is proceeded by preparation in some therapeutic room (such as 6A) in therapeutic room 6A~6C
Deng being shown via the operation console of irradiation system public computer (master controller 40), so that can confirm that other treatment
The treatment situation of room (such as 6B, 6C).Herein, whether so-called treatment situation refers to be in treatment and selected target is exhaled
Inhale sets of waveforms (α or β).Then, doctor etc. is inputted by irradiation system public computer according to the treatment situation of other treatment room
α or β in the timing group of the selection result, that is, target respiratory waveform of (master controller) management, and will be set as inputted group
(step S220).That is, each therapeutic room's selection belongs to group α or belongs to the group of group β.In addition, in this step 220S, also can not be to doctor
It is raw etc. to be shown, and judged in the controller corresponding to each therapeutic room, to select appropriate group.Alternatively, also can be right
Each therapeutic room comes in advance setting group α respectively and group β.
Therapeutic room (sub-controller 42 or navigation feature portion 22) to setting group, corresponds to from the output of master controller 40
The timing signal (step S230) of the group.By inputting the timing signal, so that selected by display corresponds in each therapeutic room
Group target respiratory waveform WIb.
If display target respiratory waveform WIb, patient can progressively adjust exhaling for oneself according to target respiratory waveform WIb
Inhale.Herein, in the case of multiple therapeutic rooms all non-selected group of α or group β, i.e. there is no the overlapping therapeutic room of ON time
In the case of (step S300 is "No"), then it is identical with the step S40 of embodiment 1, can proceed by and utilize time-sharing format
Irradiate (step S240).However, as precondition, in the case where multiple therapeutic rooms select same group, then selecting
In identical group of therapeutic room, it may appear that the overlapping situation of ON time.(step S300 is "Yes") in this case, it is following that
Sample screening becomes the therapeutic room of time-division illumination object.
Controller 40 with timing indicator more at least select same group of each therapeutic room target respiratory waveform, with
From the actual respiratory waveform (step S310) of patient respiratory measurement device 22a outputs.Then, based on comparative result, come to respectively controlling
The irradiation degree of readiness marking of room is treated, when fraction is higher than predetermined value, is judged as to be irradiated and determining as time-division illumination
The therapeutic room (step S320) of object.At this time, in it have selected same group of therapeutic room, if there is multiple treatments that can be irradiated
Room, then select the highest therapeutic room of fraction as irradiation object.Alternatively, in view of the identical feelings of fraction according to treatment content etc.
Condition, also can be prioritized to therapeutic room in advance.Alternatively, fraction can be also set to " can be irradiated " and " be not available for shining
Penetrate " the two values (0 or 1).
Thus, each therapeutic room for belonging to group α or group β is determined as time-division illumination object, is shown in identified therapeutic room
It is treatment target to show the therapeutic room, proceeds by treatment (step S240).Thus, even in the therapeutic room that can carry out time-division processing
In the case of for two, two can be also selected from more than three therapeutic rooms, to carry out timesharing treatment.On the other hand, not by
Selected therapeutic room is all holding state before another therapeutic room for belonging to same group completes treatment, and shows the standby shape
State.
The method for illustrating the marking of the irradiation preparation in step S250.
Most intuitively method is to calculate target respiratory waveform and the method for the error sum of squares of actual respiratory waveform.It is specific and
Speech, acts as follows.If T will be set to the respiratory cycle, the error sum of squares Se of k-th of respiratory cycle, which can be utilized, represents error
The formula (3) of integrated square Ie obtain.
(mathematical expression 1)
In formula, b (t) is actual respiratory waveform, and bobj (t) is target respiratory waveform.
If in addition, it is indicated in the case of time discrete, such as shown in following formula (4).
(mathematical expression 2)
In formula, n is the hits of a respiratory cycle.
Score can be obtained for example, by subtracting the mode of error sum of squares Se from basis point.
In addition, it is simpler be the respiration gated of comparison object respiratory waveform and the respiration gated of actual respiratory waveform come into
The method of row marking.At this time, preferably in a respiratory cycle, the breathing of target waveform benchmark and actual breathing both benchmark
Gate time for all turning on longer situation.Thus, the time that respiration gated under the target waveform benchmark can be also turned on and reality
Mutually the same time time that respiration gated turns under border breathing benchmark is as fraction.
For above-mentioned marking, in addition to current breathing cycle, it is also contemplated that one to two past cycle.It is so-called
The constant state for referring to be appropriate for beam exposure of breathing state.
In addition, in the above example, in order to be easier to understand the overlapping therapeutic room of ON time, turned on using preparing in advance
Time, nonoverlapping group of example was illustrated, but be not restricted to that this.For example, even if the phase of each therapeutic room is carried out
Adjustment, in the case that ON time is overlapping (the step S300 of Fig. 5), can also be selected from the overlapping therapeutic room of ON time will be into
For the therapeutic room of time-division illumination object.
As described above, 2 particle-beam therapeutic apparatus, controller 4 are used with lower structure according to the present embodiment：That is, exist
In multiple therapeutic rooms, during for example there is as have selected same group of therapeutic room, the photograph synchronous with target respiratory waveform WIb
In the case of penetrating the equitant therapeutic rooms of time TI, compare the target respiratory waveform of the equitant each therapeutic rooms of irradiation time TI
The actual respiratory waveform that WIb and respiration measuring device 22a is measured, based on comparative result, is controlled from irradiation time TI is equitant
Treat and object of the therapeutic room as Synchronization Control is selected in room, that is, be chosen to be the object being irradiated with time-sharing format, therefore,
In the case that therapeutic room's quantity is more than and can be carried out at the same time therapeutic room's quantity of irradiation, timesharing photograph also can be successfully carried out
Penetrate.
Embodiment 3.
In above formula embodiment 1 or 2, illustrate it is following under the premise of situation：That is, with time-sharing format can irradiate at the same time
Therapeutic room be two, the duty cycle of respiration gated signal BG is slightly less than 0.5.If however, as described above, reduce duty cycle,
Threshold value Th can reduce, and can improve the repeatability of the posture of affected part.In existing particle-beam therapeutic apparatus, accounted for if reducing
Empty ratio, then treatment time once can increase, can patient receiving treatment's number can reduce, it is desirable, therefore, to assure that higher duty
Than.However, in the case of the particle-beam therapeutic apparatus of the invention for using time-sharing format irradiate at the same time, even if reducing
Duty cycle, can also increase the quantity for the therapeutic room that can be carried out while irradiate, accordingly, it is capable to energy patient receiving treatment's number is maintained, and
The stability of affected part posture can be improved.Accordingly, it is capable to by the duty cycle of respiration gated signal be set to make three therapeutic rooms with
Time-sharing format is carried out at the same time irradiation, more smaller than 0.33 value (being slightly less than 1/3).In this case, phase is made to be carried out by 120
Offset, to generate three targets respiratory waveform group α, β, γ, can shine most three therapeutic rooms at the same time with time-sharing format
Penetrate.
In addition, respiration gated signal BG also can be just generated without using threshold value Th.Script target respiratory waveform WIb is just any
Value, therefore, corresponding respiration gated signal BG is also arbitrary value.For example, there are situations below：That is, in target respiratory waveform
In regions of the WIb less than threshold value Th, using only latter half.Its starting point is because wanting to use up using target respiratory waveform WIb
The region may be flat and stablized.In contrast, for actual respiratory waveform respiration gated signal generation, can easily understand that
Use the method for threshold value Th.
In addition, the duty cycle of the respiration gated signal of target respiratory waveform is being set to the smaller value of lower ratio 0.25
(being slightly less than 1/4), makes phase shift by 90 degree, can be with the case of generation four target respiratory waveform groups α, β, γ, δ
Time-sharing format to most four therapeutic rooms irradiate at the same time.
In addition, in the above example, in order to be easier to understand the overlapping therapeutic room of ON time, turned on using preparing in advance
Time, nonoverlapping group of example was illustrated, but be not restricted to that this.Such as the duty cycle according to set by current time
To adjust the phase of each therapeutic room, Continuity signal or it is overlapping in the case of, can suitably reduce duty cycle.
Thus, 2 particle-beam therapeutic apparatus, controller 4 are used with lower structure according to the present embodiment：That is, multiple
In the case of there is the overlapping therapeutic rooms of the irradiation time TI synchronous with target respiratory waveform WIb in therapeutic room, so that each shine
The mode that the ratio of the irradiation time TI synchronous with target respiratory waveform WIb of injection device 22 reduces is adjusted so that irradiation
Time, TI was not overlapping, therefore, in the case that therapeutic room's quantity is more than and can be carried out at the same time therapeutic room's quantity of irradiation, also could
Successfully carry out time-division illumination.
Embodiment 4.
In the respective embodiments described above 1 to 3, the example for the duty cycle respectively periodically organized to mean allocation is illustrated.So
And there may be not easy close to part and head for being easily subject to breathing influence of lung etc. in the position of irradiation object, that is, patient
The part for being subject to breathing to influence.That is, it is not necessarily to the duty cycle of each timing group being set as average.Therefore, in this embodiment party
In the particle-beam therapeutic apparatus of formula 4, in irradiation system public computer (master controller 40), duty cycle difference is prepared in advance
Timing group.Doctor etc. can select appropriate timing group according to the position of irradiation object, that is, patient.Alternatively, master controller 40
Duty cycle information can be extracted from the information being stored in therapy planning device, be selected based on the duty cycle information extracted
Select appropriate group.
In this case, master controller 40 is according to the duty cycle of the timing group of selected each therapeutic room, to adjust
The phase offset of each timing group so that ON time will not be overlapping.For example, the group α's selected respectively in three therapeutic rooms accounts for
Sky than be 0.15, organize β duty cycle be 0.4, organize γ duty cycle be 0.3 in the case of, make β relative to α deviate 72 degree, make γ
Deviate 234 degree relative to α, then 18 degree of switching timing can be ensured between each group, to deviate ON time, with time-sharing format into
Row irradiates at the same time.
In addition, in the case where the summation of selected group of duty cycle is more than 1, it is appropriate like that as shown in Embodiment 2
Ground limitation becomes the quantity of the therapeutic room of timesharing object so that summation is not more than 1, or as shown in Embodiment 3, carries out
Adjust to reduce duty cycle.
Label declaration
1 accelerator (synchrotron)
2 irradiation systems (21：Irradiation unit, 22：Navigation feature portion (breathing guide device) (22a：Respiration measuring device))
3 transport systems (31：Transport path, 32：Switch electromagnet (switching device))
4 control systems (controller) (40：Master controller)
6 therapeutic rooms
The C cycles
TC is using switching electromagnet come the switching timing of switch beams track
In Tf irradiation units with target respiratory waveform synchronously come stop irradiation timing
Irradiation time synchronous with target respiratory waveform TI
In To irradiation units with target respiratory waveform synchronously come start irradiation timing
WIb target respiratory waveforms
Claims (6)
1. a kind of particle-beam therapeutic apparatus, which is provided with multiple therapeutic rooms, the multiple therapeutic room
With the breathing guide device that breathing timing is indicated to patient, also, the particle-beam therapeutic apparatus is based on offset respectively and sets
The phase of the fixed breathing timing, multiple groups are categorized into by the multiple therapeutic room, in each group from the multiple group
Between the patient of the therapeutic room selected, particle ray, the feature of the particle-beam therapeutic apparatus are irradiated using time-sharing format at the same time
It is,
Including controller, which performs selects relative to the composition comprising multiple therapeutic rooms to be timesharing in the multiple group
The step of one therapeutic room of irradiation object,
Controller irradiation degree of readiness respective to the therapeutic room in the group comprising the multiple therapeutic room is given a mark, base
Value after the marking selects one therapeutic room,
Error sum of squares based on target respiratory waveform He actual respiratory waveform, to give a mark to the irradiation degree of readiness.
2. a kind of particle-beam therapeutic apparatus, which is provided with multiple therapeutic rooms, the multiple therapeutic room
With the breathing guide device that breathing timing is indicated to patient, also, the particle-beam therapeutic apparatus is based on offset respectively and sets
The phase of the fixed breathing timing, multiple groups are categorized into by the multiple therapeutic room, in each group from the multiple group
Between the patient of the therapeutic room selected, particle ray, the feature of the particle-beam therapeutic apparatus are irradiated using time-sharing format at the same time
It is,
Including controller, which performs selects in the therapeutic room in the multiple group out of group comprising multiple therapeutic rooms
The step of one therapeutic room of time-division illumination object,
Controller irradiation degree of readiness respective to the therapeutic room in the group comprising the multiple therapeutic room is given a mark, base
Value after the marking selects one therapeutic room,
Become the length of the time for the value that can allow to carry out the irradiation at the same time based on target respiratory waveform and actual respiratory waveform,
To give a mark to the irradiation degree of readiness.
3. particle-beam therapeutic apparatus as claimed in claim 1 or 2, it is characterised in that
In addition to the present respiratory cycle, it is also contemplated that one to two past cycle beats the irradiation degree of readiness
Point.
4. a kind of system of selection of irradiation object therapeutic room, multiple therapeutic rooms, which have to patient, indicates that the breathing of breathing timing guides
Device, in the particle-beam therapeutic apparatus for being provided with the multiple therapeutic room, the breathing based on offset setting respectively is determined
When phase, the multiple therapeutic room is categorized into multiple groups, the therapeutic room selected in each group from the multiple group
Between patient, particle ray is irradiated using time-sharing format at the same time, at this time, selection is relative to including multiple treatments in the multiple group
The composition of room is a therapeutic room of time-division illumination object, and the system of selection for penetrating subject room is characterized in that, including：
The process that irradiation degree of readiness respective to the therapeutic room in the group comprising the multiple therapeutic room is given a mark；And
The process that one therapeutic room is selected based on the value after the marking,
Also, the irradiation degree of readiness is beaten based on the error sum of squares of target respiratory waveform and actual respiratory waveform
Point.
5. a kind of system of selection of irradiation object therapeutic room, multiple therapeutic rooms, which have to patient, indicates that the breathing of breathing timing guides
Device, in the particle-beam therapeutic apparatus for being provided with the multiple therapeutic room, the breathing based on offset setting respectively is determined
When phase, the multiple therapeutic room is categorized into multiple groups, the therapeutic room selected in each group from the multiple group
Between patient, particle ray is irradiated using time-sharing format at the same time, at this time, selection is relative to including multiple treatments in the multiple group
The composition of room is a therapeutic room of time-division illumination object, and the system of selection for penetrating subject room is characterized in that, including：
The process that irradiation degree of readiness respective to the therapeutic room in the group comprising the multiple therapeutic room is given a mark；And
The process that one therapeutic room is selected based on the value after the marking,
Become the length of the time for the value that can allow to carry out the irradiation at the same time based on target respiratory waveform and actual respiratory waveform,
To give a mark to the irradiation degree of readiness.
6. the system of selection of irradiation object therapeutic room as described in claim 4 or 5, it is characterised in that
In addition to the present respiratory cycle, it is also contemplated that one to two past cycle beats the irradiation degree of readiness
Point.
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