CN105031354A - Unio margarita capsule used for curing gastroduodenal ulcer and preparation method and application of Unio margarita capsule - Google Patents
Unio margarita capsule used for curing gastroduodenal ulcer and preparation method and application of Unio margarita capsule Download PDFInfo
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Abstract
The invention relates to a Chinese herba preparation, in particular to a unio margarita capsule used for curing gastroduodenal ulcer and a preparation method and application of the unio margarita capsule. The unio margarita capsule is prepared from 55 to 70 parts of cuttlebone, 8 to 15 parts of Thunberg Fritillary Bulb, 0.1 to 0.15 parts of tangerine peel oil, 3 to 7 parts of fructus evodiae, 2 to 4 parts of Coptis chinensis, 2 to 3 parts of caulis bambusae in taeniam, 1.5 to 2 parts of rhizoma pinelliae preparata, 1 to 3 parts of Astragalus membranaceus and 2 to 2.5 parts of radix paeoniae alba in parts by weight, wherein the cuttlebone is shelled. The unio margarita capsule disclosed by the invention is yellowish white powder, smells slightly fragrant, tastes slightly bitter and is easy to carry, has effects of relieving hyperacidity, relieving pain and astringing to stop bleeding, has a significant curative effect on gastric ulcer and the gastroduodenal ulcer, and especially, the significant curative effect on the gastroduodenal ulcer reaches up to 88 percent.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, be specially Unio margarita capsule being used for the treatment of gastroduodenal ulcer and its preparation method and application.
Background technology
Gastroduodenal ulcer is common digestive tract disease, and its main clinical manifestation is epigastrium pain, can be dull pain, causalgia, distending pain or severe pain, also can show as the only dull pain discomfort when hunger.Typical case person shows as slightly or rest pain under moderate xiphoid-process, can be alleviated by antacid or feed.Patient has periodicity epigastrium pain, returns the symptom such as acid, belch.The easy recurrent exerbation of primary disease, in chronic process.Gastroduodenal ulcer comprises gastric ulcer and duodenal ulcer two kinds.Duodenal ulcer is common compared with gastric ulcer, and the former accounts for 70% according to statistics, and the latter accounts for 25%, both and the combined Peptic Ulcer deposited accounts for 5%.Generation and the gastroxia of duodenal ulcer have substantial connection.Duodenal ulcer disease people, its average basal acid secretory volume and maximal acid secretion amount, all calibration ordinary person exceeds a lot.
At present, the medicine for the treatment of gastroduodenal ulcer is various, based on Western medicine.Western medicine has larger side effect and dependency over the course for the treatment of, needs long-term taking.Useful pure treatment by Chinese herbs is not flavour of a drug are exactly DeGrain more yet.Still demand is existed to the medicine or other health product for the treatment of these symptoms.
Bulbus Fritillariae Uninbracteatae is herbaceos perennial, and its bulb can hyoscine.Because its shape is gained the name, Collective Notes to the Canon of Materia medica: " the poly-Monetariamoneta (L.)(Monetariaannulus (L.)) of likeness in form ", therefore named Bulbus Fritillariae Uninbracteatae.Another name: diligent mother, Herba Sonchi Oleracei, bitter flower, empty grass, medicine is real.Bulbus Fritillariae Uninbracteatae, cold nature, sweet in the mouth is pungent, mainly containing peimine, peiminine and a kind of steroid neutral compound, there is effect of lung moistening, can be used for treating exogenous cough, upper dry phlegm-syndrome is contained, dysphoria with smothery sensation is spitted blood, laryngalgia, epistaxis and human milk silt and the diseases such as the mammary gland inflammation that causes.
According to the difference of kind, Bulbus Fritillariae Uninbracteatae can be divided into Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Thunbergii and Rhizoma Bolbostematis three major types.Bulbus Fritillariae Thunbergii is the underground bulb of Liliaceae herbaceos perennial Bulbus Fritillariae Thunbergii.Because main product is gained the name in Zhejiang, therefore be called for short Bulbus Fritillariae Thunbergii.Because it originates in Xiangshan of Zhejiang Province, therefore be also called Bulbus Fritillariae Thunbergii, be called for short and resemble shellfish.Because its profile is large compared with Bulbus Fritillariae Cirrhosae, therefore be also called Bulbus Fritillariae Thunbergii, be called for short Bulbus Fritillariae Thunbergii.In Jiangsu, Anhui, the ground such as Hunan also produces.Modern pharmacological research confirms, Bulbus Fritillariae Thunbergii contains the multiple alkaloids such as peimine, peimine have alleviate bronchial muscular spasm, reduce bronchial mucosa secretion, expand pupil, reduce blood pressure, the multiple pharmacological effect such as excited uterus.In addition, Bulbus Fritillariae Thunbergii, as medicine-food two-purpose good merchantable brand, is just being widely used in the field such as food, health product now.Research and development Bulbus Fritillariae Thunbergii, is conducive to the popularization of green health diet, for masses seek to obtain welfare.
If the patent No. is the patent of invention of CN10151854A, disclose a kind of Dietotherapy medicament and preparation method for the treatment of gastric ulcer and duodenal ulcer, its with Os Sepiae, Mel for primary raw material, the application compatibility that Bulbus Fritillariae Thunbergii is used for the aspect such as gastric ulcer, duodenal ulcer is fewer, need in this respect to be excavated, still demand is existed to the medicine or other health product for the treatment of these symptoms.
Summary of the invention
In view of this, the object of the present invention is to provide a kind of Unio margarita capsule being used for the treatment of gastroduodenal ulcer.The Unio margarita capsule made is the powder of yellow-white, and feeble QI is fragrant, and mildly bitter flavor, is easy to carry about with one; There is relieving gastric hyperacidity to alleviate stomachache, anastaltic effect.Its therapeutic effect for gastric ulcer and duodenal ulcer is remarkable, effective up to 88% especially for duodenal ulcer.
For achieving the above object, the technical solution used in the present invention is as follows:
Be used for the treatment of a Unio margarita capsule for gastroduodenal ulcer, be made up of following component: the Radix Paeoniae Alba of the Rhizoma Coptidis of the Oleum Citri Reticulatae of the Endoconcha Sepiae of 55-70 mass parts, the Bulbus Fritillariae Thunbergii of 8-15 mass parts, 0.1-0.15 mass parts, the Fructus Evodiae of 3-7 mass parts, 2-4 mass parts, the Caulis Bambusae In Taenia of 2-3 mass parts, the Rhizoma Pinelliae of 1.5-2 mass parts, the Radix Astragali of 1-3 mass parts and 2-2.5 mass parts; Described Endoconcha Sepiae is shelled.
Further, described Unio margarita capsule is made up of following component: the Radix Paeoniae Alba of the Rhizoma Coptidis of the Oleum Citri Reticulatae of the Endoconcha Sepiae of 63 mass parts, the Bulbus Fritillariae Thunbergii of 11 mass parts, 0.12 mass parts, the Fructus Evodiae of 5 mass parts, 3 mass parts, the Caulis Bambusae In Taenia of 2.5 mass parts, the Rhizoma Pinelliae of 1.6 mass parts, the Radix Astragali of 2 mass parts and 2.4 mass parts.
Described Endoconcha Sepiae is the dry inner shell of Sepiidae animal sepiella maindroni de Rochebrune or golden cuttlefish.Be distributed in the ground such as Zhejiang, Fujian, Shandong.Endoconcha Sepiae has effect of astringing to arrest bleeding, relieving leukorrhea by astringents, relieving gastric hyperacidity to alleviate stomachache, removing dampness sore.The diseases such as Endoconcha Sepiae is usually used in treatment hematemesis and epistaxis, metrorrhagia is had blood in stool, emission and spermatorrhea, leucorrhea with red and white discharge, stomachache acid regurgitation, bleeding due to trauma, eczema eczema, ulcer being unable to heal.
Described Bulbus Fritillariae Thunbergii is the underground bulb of Liliaceae herbaceos perennial Bulbus Fritillariae Thunbergii.Because main product is gained the name in Zhejiang, therefore be called for short Bulbus Fritillariae Thunbergii.Because it originates in Xiangshan of Zhejiang Province, therefore be also called Bulbus Fritillariae Thunbergii, be called for short and resemble shellfish.Because its profile is large compared with Bulbus Fritillariae Cirrhosae, therefore be also called Bulbus Fritillariae Thunbergii, be called for short Bulbus Fritillariae Thunbergii.In Jiangsu, Anhui, the ground such as Hunan also produces.Bulbus Fritillariae Thunbergii bitter in the mouth and cold in nature, enter cardiopulmonary warp, function is detoxified, and clinical normal compatibility is used for the cough of expectorant heat stagnation lung and the treatment of the disease such as carbuncle poison swells and ache, scrofula is routed with Radix Scrophulariae, Concha Ostreae, Herba Taraxaci, Radix Trichosanthis, Fructus Forsythiae, Semen Coicis, Herba Houttuyniae, fresh Rhizoma Phragmitis, Spica Prunellae, Sargassum, Thallus Laminariae (Thallus Eckloniae), Rhizoma Curcumae etc.; Can treat for stomachache with medicine compatibilities such as Os Sepiae, Concha Arcae (calcined), Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Coptidis, Fructus Evodiae, Caulis Bambusae In Taenia, Rhizoma Pinelliae, acid regurgitation, heartburn.Modern pharmacological research confirms, Bulbus Fritillariae Thunbergii contains the multiple alkaloids such as peimine, peimine have alleviate bronchial muscular spasm, reduce bronchial mucosa secretion, expand pupil, reduce blood pressure, the multiple pharmacological effect such as excited uterus.
Described Fructus Evodiae another name Fructus Evodiae, tea are peppery, paint spicy, smelly spicy tree, Zuo Lichun deep and remote son, rice spicy etc.Namely the tender fruit of Fructus Evodiae is Chinese medicine Fructus Evodiae after brewed airing, is called for short Fructus Evodiae, is bitter stomachic and analgesics, makes lumbricide again.Fructus Evodiae is hot in nature, and bitter in the mouth is pungent, has effect of dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, can be used for treating that liver insufficiency of stomach is trembled with fear, the disease such as headache caused by cloudy turbid superinverse or gastralgia.
Described Rhizoma Coptidis has another name called taste company, Rhizoma Coptidis, Rhizoma Coptidis etc., is Ranunculaceae herbaceos perennial.Rhizoma Coptidis has effect of heat clearing and damp drying, eliminating fire and detoxication.Diseases such as can be used for treating damp and hot feeling of fullness, vomit acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tell nosebleed, conjunctival congestion, have a toothache, quench one's thirst, carbuncle furuncle, eczema, eczema, auditory meatus are suppurated.
Described Caulis Bambusae In Taenia is the dry intermediate layer of stem stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Caulis Bambusae In Taenia has effect of removing heat-phlegm, relieving restlessness, preventing or arresting vomiting.Can be used for treatment phlegm-heat cough, gallbladder fire and hold the disease such as expectorant, palpitation with fear not peaceful, vexed insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm.
Described Rhizoma Pinelliae is also known as the clear water Rhizoma Pinelliae, Pinellia Tuber, Pinellia Tuber sheet.Rhizoma Pinelliae is the part can be used as medicine after Rhizoma Pinelliae Alumen Processing methods.Rhizoma Pinelliae has effect of drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, can be used for the disease such as treatment damp-phlegm cold drink, vomiting, regurgitation, cough with asthma abundant expectoration, chest and diaphragm distension, syncope due to accumulation of phlegm headache, dizzy sleeplessness, outer subduing inflammation.
The history of medicinal existing more than 2000 year so far of the described Radix Astragali.The Radix Astragali has the effect eliminated Jishengshenqiwan albuminuria, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, improve blood supply of cardiac muscle, improve immunologic function, and can the process of delaying cell aging.
The described Radix Paeoniae Alba is the root of dicotyledon medicine ranunculaceae plant Radix Paeoniae (cultigen).The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, has effect of blood-supplementing blood-nourishing, suppressing liver-YANG, easing the affected liver to relieve pain, astringing YIN to stop sweating, can be used for treatment fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band.
Two of object of the present invention is to provide the method preparing described Unio margarita capsule, and it is simple to operate, can large-scale production.
The preparation method of above-mentioned Unio margarita capsule, specifically comprises the following steps:
A. get the Endoconcha Sepiae powder of above-mentioned weight portion, Bulbus Fritillariae Thunbergii, Fructus Evodiae, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali, the Radix Paeoniae Alba obtain compositions A, the Oleum Citri Reticulatae getting above-mentioned weight portion obtains compd B;
B. compositions A described in steps A is placed in mixer to mix, then mixes after adding compd B, mix homogeneously is placed on capsule filler and carries out capsule charge;
C. step B resulting articles is carried out polishing in capsule polisher.
Further, the pre-treatment step in described steps A is: carry out sterilizing to compositions A, pulverize and sieve and process to obtain Endoconcha Sepiae powder, Bulbus Fritillariae Thunbergii powder, evodiae powder, Rhizoma Coptidis powder, Caulis Bambusae In Taenia powder, Rhizoma Pinelliae powder, astragalus membranaceus powder, Radix Paeoniae Alba powder.
Further, the preparation of described Unio margarita capsule is further comprising the steps of: by step C gained always mixed powder be placed in capsule charge indoor, with Capsules encapsulation, more packaged capsule is placed in blister packaging machine, packs with aluminum-plastic blister, Unio margarita capsule.
Further, described Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, Fructus Evodiae, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali, Radix Paeoniae Alba Highefficientpulverizer are pulverized, material after pulverizing, Endoconcha Sepiae, Bulbus Fritillariae Thunbergii cross the spin vibration sieve of installation 60 mesh sieve, Fructus Evodiae crosses the spin vibration sieve of installation 50 mesh sieve, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali cross spin vibration sieve, the Radix Paeoniae Alba of installing 100-120 mesh sieve and cross the spin vibration sieve of installing 200-260 mesh sieve, and whole pulverizing medicinal materials is until by regulation order number sieve net.
Further, the antibacterial of described Endoconcha Sepiae powder, Bulbus Fritillariae Thunbergii powder, evodiae powder, Rhizoma Coptidis coarse powder, Caulis Bambusae In Taenia coarse powder, Rhizoma Pinelliae coarse powder, radix astragali coarse powder, Radix Paeoniae Alba coarse powder must not be greater than 5000, mycete yeast must not be greater than 50.
Further, 30 minutes must not be greater than the disintegration of described Unio margarita capsule finished product.
The present invention also aims to provide above-mentioned Unio margarita capsule to be used for the treatment of application in duodenal ulcer.
Beneficial effect of the present invention is:
The method preparing Unio margarita capsule of the present invention, it is simple to operate, can large-scale production.Unio margarita capsule appearance of the present invention is yellow-white powder, and feeble QI is fragrant, and mildly bitter flavor, is easy to carry about with one; There is relieving gastric hyperacidity to alleviate stomachache, anastaltic effect, can be used in treatment gastric ulcer and duodenal ulcer.It is remarkable to the therapeutic effect of gastric ulcer, duodenal ulcer, effective up to 88% especially for duodenal ulcer.
Detailed description of the invention
Illustrated embodiment is to be described content of the present invention better, but is not that content of the present invention is only limitted to illustrated embodiment.Those of ordinary skill in the art carry out nonessential improvement and adjustment according to foregoing invention content to embodiment, still belong to protection scope of the present invention.Clear out a gathering place by " raw prenatal diagnosis and validation criteria rule of management ", " pretreatment workshop extracts post standard operating procedure ", " standard management code of clearing out a gathering place " execution after life prenatal diagnosis and production.
Embodiment 1 is used for the treatment of the Unio margarita capsule formula of gastroduodenal ulcer
Formula 1: Endoconcha Sepiae (peeling) 55g, Bulbus Fritillariae Thunbergii 15g, Oleum Citri Reticulatae 0.15g, Fructus Evodiae 3g, Rhizoma Coptidis 2g, Caulis Bambusae In Taenia 3g, Rhizoma Pinelliae 1.5g, Radix Astragali 3g and Radix Paeoniae Alba 2g.
Formula 2: Endoconcha Sepiae (peeling) 70g, Bulbus Fritillariae Thunbergii 8g, Oleum Citri Reticulatae 0.1g, Fructus Evodiae 7g, Rhizoma Coptidis 4g, Caulis Bambusae In Taenia 2g, Rhizoma Pinelliae 3g, Radix Astragali 1g and Radix Paeoniae Alba 2.5g.
Formula 3: Endoconcha Sepiae (peeling) 63g, Bulbus Fritillariae Thunbergii 11g, Oleum Citri Reticulatae 0.12g, Fructus Evodiae 5g, Rhizoma Coptidis 3g, Caulis Bambusae In Taenia 2.5g, Rhizoma Pinelliae 1.6g, Radix Astragali 2g and Radix Paeoniae Alba 2.4g.
Embodiment 2 is used for the treatment of preparation technology's flow process of the Unio margarita capsule of gastroduodenal ulcer
Formula crude drug described in embodiment one is made Unio margarita capsule, and idiographic flow is as follows:
1. the pretreatment of crude drug
Sterilization treatment is carried out to Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, Fructus Evodiae, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali, the Radix Paeoniae Alba, temperature is 121 DEG C, sterilization time 2 hours, take out medical material from clean area and be loaded in clean bucket, weigh.
2. pulverize and sieve
Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, Fructus Evodiae, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali, Radix Paeoniae Alba Highefficientpulverizer are pulverized, material after pulverizing, Endoconcha Sepiae, Bulbus Fritillariae Thunbergii cross the spin vibration sieve of installation 60 mesh sieve, Fructus Evodiae crosses the spin vibration sieve of installation 50 mesh sieve, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali cross spin vibration sieve, the Radix Paeoniae Alba of installing 100-120 mesh sieve and cross the spin vibration sieve of installing 200-260 mesh sieve, and whole pulverizing medicinal materials is until by regulation order number sieve net.
3. batching is total mixed
First Endoconcha Sepiae, Bulbus Fritillariae Thunbergii are first mixed 5 minutes by Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, Fructus Evodiae, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali, the Radix Paeoniae Alba, then mix 15 minutes after adding Oleum Citri Reticulatae.After having mixed, take out powder and be contained in clean container airtight.
4. capsule charge
The total mixture got through being up to the standards carries out capsule charge to capsule filler, and content is at 0.5g, and control content uniformity in ± 10% scope, speed controlling is set as weighing once for every 15 minutes.Capsule good for filling is carried out polishing, and controlling buffing machine rotating speed is 18 revs/min.
5. aluminium-plastic bubble plate packing
The capsule of polishing is placed in blister packaging machine and carries out aluminium-plastic bubble plate packing, heat-sealing temperature controls within the scope of 190 ± 20 DEG C, and plastic uptake Control of Voltage is within the scope of 190 ± 20v, and vacuum is 0.09Mpa.
6. outer package
The capsule good through aluminium-plastic bubble plate packing is carried out outer package, and packing specification is 10/plate × 4 plate/box × 100 box/case.A description is put in each box; A work certificate, batch inspection report is put in each case (part); Each case (part) two straps are packed, and pack with fastener for bundling articles; Lot number on box, carton, date of manufacture, effect duration, packaging directive printing was errorless, position is correctly clear by criticizing; Mounted box, packing number are accurate; Case is stamped the lot number of two batches of filled products.
Embodiment 3 product quality and quality
Unio margarita capsule intermediate products quality standard
Unio margarita capsule finished product quality standard:
The application of embodiment 4 Unio margarita capsule
For verifying the good effect of Unio margarita capsule of the present invention, inventors performed a large amount of tests, after the patient being applicable to surrounding area, place, inventor residence, have received good effect.According to the situation of accepting patient for medical treatment, be summarized as follows: accept for medical treatment patient totally 120 example, 18-50 year between, wherein male 58 example, women 62 example.
Now select part clinical experiment report as follows:
1. diagnosis and treatment evaluation criteria
Recovery from illness: clinical symptom disappearance, drug withdrawal has no recurrence half a year.
Effective: symptom alleviates, but do not take a turn for the better completely.
Invalid: symptom is without obvious change.
2. Syndrome Differentiation of Traditional Chinese Medicine, doctor trained in Western medicine inspection diagnostic result.
3. pharmaceutical procedures: dosage of the present invention depends on the factors such as patient age, body weight and health status.Therefore concrete used in amounts according to practical situations such as the pathological characters of patient, the concrete causes of disease, due to illness will treat.
As medication guide, get Endoconcha Sepiae (shelling) 55-70g, Bulbus Fritillariae Thunbergii 8-15g, Oleum Citri Reticulatae 0.1-0.15g, Fructus Evodiae 3-7g, Rhizoma Coptidis 2-4g, Caulis Bambusae In Taenia 2-3g, Rhizoma Pinelliae 1.5-2g, Radix Astragali 1-3g and Radix Paeoniae Alba 2-2.5g, take after being prepared into capsule according to the preparation method of Unio margarita capsule, sooner or later respectively once.
Preferably, the amount of each component is: Endoconcha Sepiae (shelling) 63g, Bulbus Fritillariae Thunbergii 11g, Oleum Citri Reticulatae 0.12g, Fructus Evodiae 5g, Rhizoma Coptidis 3g, Caulis Bambusae In Taenia 2.5g, Rhizoma Pinelliae 1.6g, Radix Astragali 2g, Radix Paeoniae Alba 2.4g.
4. clinical data gathers:
From the above results, Unio margarita capsule prepared by the application is remarkable to the therapeutic effect of gastric ulcer and duodenal ulcer, especially to duodenal ulcer effective up to 88% (herein, effective comprise recovery from illness and effectively).
Below choose model case to illustrate:
Model case 1: grandson, man, 41 years old, epigastrium was distending pain after meal, acid regurgitation, after examination in hospital, be diagnosed as gastric ulcer.Through using following Chinese medicine formula:
Endoconcha Sepiae (peeling) 55g, Bulbus Fritillariae Thunbergii 15g, Oleum Citri Reticulatae 0.15g, Fructus Evodiae 3g, Rhizoma Coptidis 2g, Caulis Bambusae In Taenia 3g, Rhizoma Pinelliae 1.5g, Radix Astragali 3g and Radix Paeoniae Alba 2g.Take after being prepared into capsule according to the preparation method of Unio margarita capsule, sooner or later respectively once.
Take medicine after two weeks, patient pain's symptom is alleviated gradually; After two months, pain symptom disappears, and does not recur again.
Model case 2: Wang, 53 years old, early there is epigastrium severe pain in 1-3 hour after the meal in female, rear midnight, often pain was waken up, after examination in hospital, be diagnosed as duodenal ulcer.Through using following Chinese medicine formula:
Endoconcha Sepiae (shelling) 63g, Bulbus Fritillariae Thunbergii 11g, Oleum Citri Reticulatae 0.12g, Fructus Evodiae 5g, Rhizoma Coptidis 3g, Caulis Bambusae In Taenia 2.5g, Rhizoma Pinelliae 1.6g, Radix Astragali 2g and Radix Paeoniae Alba 2.4g, take after being prepared into capsule according to the preparation method of Unio margarita capsule, sooner or later respectively once.
Take medicine after January, patient after the meal pain symptom is alleviated gradually; After two months, the awake frequency of pain at midnight is less gradually; After three months, all transference cures, and do not recur again.
What finally illustrate is, above embodiment is only in order to illustrate technical scheme of the present invention and unrestricted, those of ordinary skill in the art is to be understood that, can modify to technical scheme or equivalent replacement, and not departing from aim and the scope of technical solution of the present invention, it all should be encompassed in the middle of right of the present invention.
Claims (9)
1. one kind is used for the treatment of the Unio margarita capsule of gastroduodenal ulcer, it is characterized in that, be made up of following component: the Radix Paeoniae Alba of the Rhizoma Coptidis of the Oleum Citri Reticulatae of the Endoconcha Sepiae of 55-70 mass parts, the Bulbus Fritillariae Thunbergii of 8-15 mass parts, 0.1-0.15 mass parts, the Fructus Evodiae of 3-7 mass parts, 2-4 mass parts, the Caulis Bambusae In Taenia of 2-3 mass parts, the Rhizoma Pinelliae of 1.5-2 mass parts, the Radix Astragali of 1-3 mass parts and 2-2.5 mass parts; Described Endoconcha Sepiae is shelled.
2. Unio margarita capsule according to claim 1, is characterized in that: be made up of following component: the Radix Paeoniae Alba of the Rhizoma Coptidis of the Oleum Citri Reticulatae of the Endoconcha Sepiae of 63 mass parts, the Bulbus Fritillariae Thunbergii of 11 mass parts, 0.12 mass parts, the Fructus Evodiae of 5 mass parts, 3 mass parts, the Caulis Bambusae In Taenia of 2.5 mass parts, the Rhizoma Pinelliae of 1.6 mass parts, the Radix Astragali of 2 mass parts and 2.4 mass parts.
3. prepare the method for Unio margarita capsule as claimed in claim 1 or 2, it is characterized in that: specifically comprise the following steps:
A. get the Endoconcha Sepiae of above-mentioned weight portion, Bulbus Fritillariae Thunbergii, Fructus Evodiae, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali, the Radix Paeoniae Alba obtain compositions A, the Oleum Citri Reticulatae getting above-mentioned weight portion obtains compd B;
B. compositions A described in steps A is placed in mixer to mix, then mixes after adding compd B, after mix homogeneously, carry out capsule charge with capsule filler;
C. step B resulting articles is carried out polishing in capsule polisher.
4. method according to claim 3, it is characterized in that, the pre-treatment step in steps A is: carry out sterilizing to compositions A, pulverize and sieve and process to obtain Endoconcha Sepiae powder, Bulbus Fritillariae Thunbergii powder, evodiae powder, Rhizoma Coptidis powder, Caulis Bambusae In Taenia powder, Rhizoma Pinelliae powder, astragalus membranaceus powder, Radix Paeoniae Alba powder.
5. method according to claim 3, is characterized in that, further comprising the steps of:
D. by step C gained always mixed powder be placed in capsule charge indoor, with Capsules encapsulation, more packaged capsule is placed in blister packaging machine, packs with aluminum-plastic blister, Unio margarita capsule.
6. method according to claim 3, it is characterized in that: Endoconcha Sepiae, Bulbus Fritillariae Thunbergii, Fructus Evodiae, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali, Radix Paeoniae Alba Highefficientpulverizer are pulverized, material after pulverizing, Endoconcha Sepiae, Bulbus Fritillariae Thunbergii cross the spin vibration sieve of installation 60 mesh sieve, Fructus Evodiae crosses the spin vibration sieve of installation 50 mesh sieve, Rhizoma Coptidis, Caulis Bambusae In Taenia, Rhizoma Pinelliae, the Radix Astragali cross spin vibration sieve, the Radix Paeoniae Alba of installing 100-120 mesh sieve and cross the spin vibration sieve of installing 200-260 mesh sieve, and whole pulverizing medicinal materials is until by regulation order number sieve net.
7. method according to claim 4, is characterized in that: the antibacterial of described Endoconcha Sepiae powder, Bulbus Fritillariae Thunbergii powder, evodiae powder, Rhizoma Coptidis coarse powder, Caulis Bambusae In Taenia coarse powder, Rhizoma Pinelliae coarse powder, radix astragali coarse powder, Radix Paeoniae Alba coarse powder must not be greater than 5000, mycete yeast must not be greater than 50.
8. the Unio margarita capsule for preparing of method described in any one of claim 3-7, is characterized in that: the disintegration of described Unio margarita capsule must not be greater than 30 minutes.
9. the Unio margarita capsule that prepared by claim 7 is used for the treatment of the application in duodenal ulcer.
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| CN114404387A (en) * | 2022-01-18 | 2022-04-29 | 重庆多普泰制药股份有限公司 | A Bulbus Fritillariae Cirrhosae granule and its preparation method |
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| CN105031354B (en) | 2018-03-30 |
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