CN105031211B - A kind of HUANGQI SHENGMAI YIN extract powder and preparation method thereof - Google Patents
A kind of HUANGQI SHENGMAI YIN extract powder and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of HUANGQI SHENGMAI YIN extract powders and preparation method thereof, belong to technical field of traditional Chinese medicine preparation.The HUANGQI SHENGMAI YIN extract powder is uniformly mixed by HUANGQI SHENGMAI YIN medicinal extract with appropriate amount of auxiliary materials, is obtained through drying, screening or drying, crushing, screening, and the auxiliary material is any one or two kinds in calcium monohydrogen phosphate, low-substituted hydroxypropyl cellulose, mannitol.The present invention carries out auxiliary material selection, Formulation and process optimization, obtains the HUANGQI SHENGMAI YIN extract powder with good appearance, mobility and moisture resistance for the big HUANGQI SHENGMAI YIN medicinal extract of viscosity.Preparation method of the invention solves HUANGQI SHENGMAI YIN extract dry complex process, and equipment requirement is high, the practical problem that cost is difficult to decrease, and lays the foundation with filling for follow-up granulation, in addition, the method for the present invention also has many advantages, such as that drying efficiency is high.
Description
Technical field
The present invention relates to a kind of HUANGQI SHENGMAI YINs（HQSMY）Extract powder and preparation method thereof belongs to Chinese medicine preparation technology neck
Domain.
Background technology
It is the light brown that extracts of raw material to red that HQSMY medicinal extract, which is by Radix Astragali, Radix Codonopsis, Radix Ophiopogonis, Schisandra chinensis, kadsura longepedunculata,
The supernatant liquid of brown, it is concentrated to obtain.Contain a large amount of polysaccharide in HQSMY medicinal extract, viscosity is big, dry difficult.Using traditional drying
Or vacuum drying, drying efficiency is low, and crushes difficulty, and gained powder hygroscopicity is strong, poor fluidity, and Combination is poor.Spray drying
Or although the methods of freeze-drying can directly prepare powder, production cost is high, and equipment requirement is high, and gained powder still has suction
It is moist strong, the problems such as poor fluidity, Combination is poor.
Chinese patent publication No. CN102048765A, date of publication, which discloses one kind on May 11st, 2011, prevents Chinese medical concrete
The method of powder moisture absorption caking is the anticaking agent added in traditional Chinese medicinal extract powder by weight percentage for 2-10%；Wherein
Anticaking agent be to be made of the raw material including following weight part ratio：1-10 parts of magnesia, 1-10 parts of superfine silicon dioxide.This
Inventive method is simple for process, easy to operate, few using auxiliary material, moisture-proof, resistive connection effect is good.But it still has following deficiencies：This method
It is after powder is made in Chinese medical concrete, to be mixed with anticaking agent, without fundamentally solving to ask existing for Chinese medical concrete powder
Topic, and unavoidably there is the powder moisture absorption, mixing problem of non-uniform during mixing.
Invention content
It is an object of the invention to solve the deficiencies in the prior art, a kind of HQSMY extract powders are provided.The HQSMY extract powders
Face shaping is good, and stability is good, not easy to moisture absorption, can be used for pelletizing and capsule is filling.
It is another object of the present invention to provide a kind of preparation methods of HQSMY extract powders, and this method is simple for process, right
Equipment requirement is relatively low, and production cost and energy consumption are relatively low.
The technical solution that the present invention solves the use of its technical problem is as follows：
A kind of HQSMY extract powders, the HQSMY extract powders are uniformly mixed by HQSMY medicinal extract with appropriate amount of auxiliary materials, through drying,
Screening or dry, crushing, screening obtain, and the auxiliary material is any one or two kinds in calcium monohydrogen phosphate, L-HPC, mannitol.
The high temperature drying technology that traditional Chinese medicine extract dry uses, which takes, is up to a couple of days, and for the more leaching of polyoses content
Cream（Such as HQSMY medicinal extract）It is difficult to drying thoroughly, the dry product obtained easily lumps, and very big be stranded is brought for the crushing etc. in later stage
It is difficult；And freeze-drying etc. is high to equipment requirement, cost is difficult to decrease, and the medicinal extract power stability that traditional handicraft obtains is very poor, cruelly
Dew is easy the moisture absorption in air, it usually needs prepares granule or capsule by integration apparatus.
Excellent auxiliary material is had chosen in the present invention, HQSMY medicinal extract is mixed with appropriate amount of auxiliary materials, is easily uniformly mixed, uniformly
Degree is high, after mixing using oven drying by the way of can the rapid draing within a few hours, then drying efficiency height sieves
Good fluidity, evengranular medicinal extract powder are obtained, solves HQSMY medicinal extract powder defect easy to moisture absorption, obtained HQSMY leachings
Cream powder has good resistance to water soak in 2 ~ 24 hours, can be used for pelletizing and capsule is filling, without to granulation and capsule
Filling humidity environment does harsh requirement, you can ensures granulation and the filling quality of capsule.
Preferably, the density of the HQSMY medicinal extract is 1.1-1.4g/ml, and the mass ratio of HQSMY medicinal extract and auxiliary material is 1:
2-1：10.The proportioning of HQSMY medicinal extract and auxiliary material within this range when, the two mixing after mixed material i.e. be in powdery, using baking oven
To get dry HQSMY powder, face shaping, mobility and the anti-suction of the HQSMY extract powders of acquisition after dry or microwave drying
Tide performance is preferable, and granular material is few, and compass screen surface object is few after screening, yield height of HQSMY extract powders.
Preferably, the density of the HQSMY medicinal extract is 1.2-1.3g/ml, and the mass ratio of HQSMY medicinal extract and auxiliary material is 1:
3-1：5.The water content of HQSMY medicinal extract and with the proportioning of auxiliary material within this range when be optimal design, the HQSMY extract powders of acquisition
Face shaping, mobility and anti-moisture absorption performance it is best.
Preferably, the equal proportion mixture that the auxiliary material is arbitrary two kinds in calcium monohydrogen phosphate, L-HPC, mannitol.The application
Inventor find that under equal conditions, the arbitrary two kinds of equal proportions of above-mentioned auxiliary material mix the HQSMY extract powders obtained as auxiliary material
Quality it is more excellent.
Preferably, the hybrid mode of the HQSMY medicinal extract and auxiliary material is：The HQSMY medicinal extract of formula ratio is at the uniform velocity added and is matched
It is stirring while adding in the auxiliary material just measured, until being sufficiently mixed uniformly.The selection of hybrid mode to the qualities of HQSMY extract powders and
Yield has a major impact, HQSMY medicinal extract toward in auxiliary material plus, can be adsorbed to avoid auxiliary material supersaturation, wall sticking phenomenon occur, influence to mix
Close effect；The hybrid mode that the present invention selects can be adsorbed to avoid auxiliary material supersaturation, and no wall sticking phenomenon ensure that HQSMY medicinal extract
The uniformity and quality of powder.
A kind of preparation method of HQSMY extract powders, the preparation method carry out as follows：
（1）Prepare the HQSMY medicinal extract and auxiliary material of formula ratio；
（2）The HQSMY medicinal extract of formula ratio is at the uniform velocity added in auxiliary material, it is stirring while adding, until being sufficiently mixed uniformly；
（3）By step（2）Uniformly mixed material obtains HQSMY through drying, screening and soaks powder.
Preferably, the mass ratio of the HQSMY medicinal extract and auxiliary material is 1: 2-1：The density of 10, HQSMY medicinal extract is 1.1-
1.4g/ml, the auxiliary material are any one or two kinds in calcium monohydrogen phosphate, L-HPC, mannitol.
Preferably, the mass ratio of the HQSMY medicinal extract and auxiliary material is 1: 3-1：The density of 5, HQSMY medicinal extract is 1.2-
1.3g/ml, the auxiliary material are arbitrary two kinds of equal proportion mixture in calcium monohydrogen phosphate, L-HPC, mannitol.
The beneficial effects of the invention are as follows：The present invention carries out auxiliary material selection, Formulation for the big HQSMY medicinal extract of viscosity
And process optimization, the HQSMY extract powders with good appearance, mobility and moisture resistance are obtained, obtained dry powder is 2 ~ 24
There is good resistance to water soak in hour, can be used for pelletizing and capsule is filling.The preparation method of the present invention can be fast within a few hours
Speed obtains good fluidity, and evengranular medicinal extract powder solves HQSMY extract dry complex process, and equipment requirement is high, cost
The practical problem being difficult to decrease lays the foundation for follow-up granulation with filling, in addition, the method for the present invention also has drying efficiency high
The advantages that.
Description of the drawings：
The appearance ongoing change figure of sample in influence experiment of Fig. 1 supplementary product kinds to moisture absorption；
The sucting wet curve of sample in influence experiment of Fig. 2 supplementary product kinds to moisture absorption；
The fluidity testing result figure of powder in influence experiment of Fig. 3 supplementary product kinds with compounding to powder flowbility.
Specific embodiment：
By prescription screening experiment, technical scheme of the present invention will be further explained in detail with specific embodiment.
1, drying time and moisture pick-up properties evaluation
Reference substance（HQSMY medicinal extract powder）Preparation：Take 10gHQSMY medicinal extract（Density 1.2mg/ml）, it is placed in 80 DEG C of baking ovens
To being completely dried, drying time is recorded.
Rx1（L-HPC HQSMY medicinal extract powder）,Rx2（Calcium monohydrogen phosphate HQSMY medicinal extract powder）And Rx3（Mannitol HQSMY
Medicinal extract powder）Preparation：By 10gHQSMY medicinal extract（Density 1.2mg/ml）30gL-HPC or calcium monohydrogen phosphate or sweet dew is at the uniform velocity added
It is stirring while adding in alcohol, until being sufficiently mixed uniformly.Uniformly mixed material tiling is placed in the 80 DEG C of dryings of normal drying device,
Record drying time.
Above-mentioned drying sample, pulverizes and sieves respectively, obtains fine powder.It is real that open hygroscopicity is carried out in 37 DEG C, under the conditions of RH75%
It tests, observes the mobility of appearance and fine powder.
The results are shown in table below, explanation：The addition of L-HPC or calcium monohydrogen phosphate or mannitol to medicinal extract powder drying efficiency,
Appearance, hygroscopicity and mobility have significant optimization.
| Drying time | Moisture pick-up properties | |
| Control | 4 days | It obviously becomes sticky after 2 hours, obvious liquefaction after 4 hours |
| Rx1 | 4 hours | Appearance does not change substantially after 8 hours, and powder flowbility is good. |
| Rx2 | 4 hours | Appearance does not change substantially after 8 hours, and powder flowbility is good. |
| Rx3 | 4 hours | Appearance does not change substantially after 8 hours, and powder flowbility is good. |
2, the comparison of drying mode
Take 10gHQSMY medicinal extract（Density 1.1mg/ml）, it is dried using different drying modes and prepares medicinal extract powder.
Evaluate drying time and effect, the complexity that evaluation dried object is crushed and further mixed, specifically using calcium monohydrogen phosphate as showing
Example, L-HPC and mannitol have same drying effect.
As a result such as following table, explanation：A certain amount of auxiliary material is added, is greatly improved drying efficiency, is using common equipment of crop drying
It can realize quick and complete drying, obtain dry thorough extract powder, without further crushing, and mobility and Combination are good,
Be conducive to subsequent processing.
| Drying mode | Drying time | Drying effect | Post-processing |
| A conventional oven is dried | 3 days | Not exclusively | It need to further crush, gained powder flowbility and Combination are poor |
| Vacuum drying oven is dried | 1 day | Completely | It need to further crush, gained powder flowbility and Combination are poor |
| It is mixed with 50g calcium monohydrogen phosphates, a conventional oven drying | 3 hours | Completely | Without further crushing, gained powder flowbility and Combination are good |
| It is mixed with 50g calcium monohydrogen phosphates, vacuum drying oven drying | 2 hours | Completely | Without further crushing, gained powder flowbility and Combination are good |
3, the influence of supplementary product kind and its compounding to moisture absorption
Reference substance（HQSMY medicinal extract powder）Preparation：Take 10gHQSMY equivalent extracts（Density is 1.1g/ml）, it is placed in 80 DEG C
Oven drying 3 days, pulverizes and sieves.
Rx1 (sodium carboxymethylcelluloses：HQSMY=10:1 medicinal extract powder), Rx2 (superfine silica gel powders：HQSMY=10:1 leaching
Cream powder), Rx3 (calcium monohydrogen phosphates：HQSMY=10:1 medicinal extract powder), Rx4 (L-HPC：HQSMY=10:1 medicinal extract powder),
Rx5 (mannitol：HQSMY=10:1 medicinal extract powder, Rx6 (polyvinylpyrrolidones：HQSMY=10:1 medicinal extract powder), Rx7
（L-HPC:CaHPO4:HQSMY=5:5:1 medicinal extract powder), Rx8（L-HPC:Mannitol:HQSMY=5:5:1 medicinal extract powder）,
Rx9（Mannitol:CaHPO4:HQSMY=5:5:1 medicinal extract powder）Preparation：By 10gHQSMY medicinal extract（Density is 1.1g/ml）
At the uniform velocity it is added in the auxiliary material of corrresponding quality proportioning, it is stirring while adding, until being sufficiently mixed uniformly.Uniformly mixed material is tiled
It is placed in the drying 4 hours of 80 DEG C of normal drying device.
Above-mentioned drying sample, open hygroscopicity experiment is carried out in 37 DEG C, under the conditions of RH75%, and timing photograph record appearance becomes
Change, periodically weigh and calculate hydroscopicity, draws sucting wet curve.
As a result：By each sample appearance（Fig. 1）It is found that control group powder after 2 hours viscosity obviously increase, base after 4 hours
This liquefaction.Viscosity obviously increases after Rx6 powder 8 hours, and appearance does not change substantially after remaining each group powder 8 hours.
By each sample sucting wet curve（Fig. 2）Known to：It is most easy to moisture absorption to compare powder, the weightening of moisture absorption in 8 hours about 16%；Rx1,Rx6
The hygroscopicity of powder is declined, and the weightening of moisture absorption in 8 hours about 17%, the anti-moisture sorption effect of Rx2, Rx4 powder is preferable, 8 hours
Moisture absorption weightening about 6% and 5%.The anti-moisture sorption effect of Rx3, Rx5 powder is best, and moisture absorption weightening in 8 hours is less than 1%.Rx7,Rx8,
The resistance to water soak of Rx9 is good, and respectively less than 5%.
Therefore, the preferable auxiliary material of moisture resistance is respectively：Mannitol, calcium monohydrogen phosphate, L-HPC, mannitol and calcium monohydrogen phosphate are multiple
Match, L-HPC and mannitol compounding, L-HPC and calcium monohydrogen phosphate are compounded.
4, the auxiliary ratio of medicine is on powder appearance and hygroscopic influence
Reference substance（HQSMY medicinal extract powder）Preparation：Take 10gHQSMY equivalent extracts（Density is 1.1g/ml）, it is placed in 80 DEG C
Oven drying 3 days, pulverizes and sieves.
Mannitol, calcium monohydrogen phosphate, L-HPC each 10g, 30g, 40g, 50g and 100g are taken respectively, by 10gHQSMY medicinal extract（It is close
Degree is 1.1g/ml）At the uniform velocity it is added in auxiliary material, it is stirring while adding, until being sufficiently mixed uniformly.Uniformly mixed material tiling is set
In the drying 4 hours of 80 DEG C of normal drying device.It is 1 to prepare auxiliary material and medicinal extract ratio:1,3:1,4:1,5:1 and 10:1 HQSMY leachings
Cream powder.Observe the appearance of above-mentioned several samples；Sample is placed in 37 DEG C, in the environment of 75%RH, the legal time measures using weighing
Hydroscopicity.
As a result：Above-mentioned various auxiliary materials 1:, obtained mixed-powder not satisfactory to the suction-operated of medicinal extract after 1 addition
Grain difference in size is apparent, or even occurs cohering phenomenon, and the color of particle is also uneven.Above-mentioned various auxiliary materials 3:1,4:1,5:1 He
10:1 be added after obtained mixed-powder particle it is uniform, color is uniform, flows similar temperament, be conducive to subsequently to pelletize with it is filling.
Hygroscopicity experiment shows auxiliary material 1:The purer HQSMY medicinal extract powder of hygroscopicity after 1 addition reduces, but anti-moisture sorption effect is not as good as auxiliary
Material 3:1,4:1,5:1 and 10:1 is added.Experimental result also shows：It is anti-for the HQSMY medicinal extract powder that medicinal extract and auxiliary material are mixed to prepare
Moisture sorption effect and the not simple linear relationship of the auxiliary additive amount of medicine, it is related with the type of auxiliary material.As medicinal extract and CaHPO4 are mixed
After conjunction, moisture absorption in 8 hours of powder is increased weight：Auxiliary material 10:1 is added（Weightening 1.12%）Better than auxiliary material 5:1 is added（Weightening 2.22%）
Better than auxiliary material 3:1 is added（Weightening 3.68%）Better than auxiliary material 4:1 is added (weightening 4.95%）.After medicinal extract is mixed with L-HPC, powder
Moisture absorption weightening in 8 hours：Auxiliary material 4:1 is added（Weightening 8.42%）Better than auxiliary material 10:1 is added（Weightening 9.35%）Better than auxiliary material 3:1
It is added（Weightening 11.02%）Better than auxiliary material 5:1 is added（Weightening 11.09%）, the reason of non-linear relationship needs the hair of the application
A person of good sense further studies.
Therefore, the mass ratio ranging from 2-10 of auxiliary material and medicinal extract is selected:1, and from the addition pair of production cost and auxiliary material
The influence of subsequent operation considers that the optimum quality ratio of auxiliary material and HQSMY medicinal extract is 3-5:1.
5, the influence of supplementary product kind and compounding to powder flowbility
By 10gHQSMY medicinal extract（Density is 1.1g/ml）It is at the uniform velocity added in the auxiliary material of variety classes and different quality ratio, side
Edged stirs, until being sufficiently mixed uniformly.Uniformly mixed material tiling is placed in 80 DEG C of oven dryings, prepares HQSMY medicinal extract
Powder.It takes 5g samples evenly laid out in the bottom of measuring cup, is placed 8 hours in 37 DEG C of temperature, the environment that relative humidity is 75%,
And the powder fluidity before and after powder moisture absorption is measured respectively.Rx1 is CaHPO4:Extract granule=10:1, Rx2 L-HPC:Medicinal extract
Particle=10:1, Rx3 is mannitol:Extract granule=10:1, Rx4 L-HPC:CaHPO4:Medicinal extract=5:5:1, Rx5 L-HPC:
Mannitol:Medicinal extract=5:5:1, Rx6 is mannitol:CaHPO4:Medicinal extract=5:5:1, Rx7 is starch：Medicinal extract=10:1, Rx8 MCC：
Medicinal extract=10:1, Rx9 dextrin：Medicinal extract=10:1, Rx10 is dextrin：MCC：Medicinal extract=5:5:1, Rx11 is dextrin：Starch：Medicinal extract=5:
5:1, Rx12 is starch：MCC：Medicinal extract=5:5:1.The fluidity testing result of sample is shown in Fig. 3.
As a result：The optimal auxiliary material of mobility is L-HPC, and the optimal auxiliary material compound scheme of mobility is L-HPC and phosphoric acid hydrogen
Calcium compounds, L-HPC and mannitol compounding.The result of comprehensive hygroscopicity evaluation：Although the anti-moisture sorption effect of L-HPC is not so good as phosphoric acid hydrogen
Calcium and mannitol, but the good fluidity of L-HPC, bulk properties can still receive.L-HPC, calcium monohydrogen phosphate and mannitol compounding make
Used time, anti-moisture absorption and mobility can be taken into account, compounding is a kind of preferable scheme.
Embodiment 1：
Take 10g HQSMY medicinal extract（1.1g/ml）At the uniform velocity it is added in 40g calcium monohydrogen phosphates, it is stirring while adding, until being sufficiently mixed
Uniformly.Uniformly mixed material tiling is placed in dry 4h, sieving in 80 DEG C of baking oven, HQSMY extract powders are made.Powder particle
Size is more uniform, and color is uniform.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, are weighed and are calculated hydroscopicity.As a result：Before and after moisture absorption
For appearance without significant change, it is 4.95% to increase weight.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, measure powder flowbility, the front and back flowing of moisture absorption
It is slightly changed, angle of repose is respectively 35.5 ° and 38.7 °
Embodiment 2：
Take 10g HQSMY medicinal extract（1.4g/ml）At the uniform velocity it is added in 30g mannitol, it is stirring while adding, until being sufficiently mixed
It is even.Uniformly mixed material tiling is placed in dry 4h, sieving in 80 DEG C of baking oven, HQSMY extract powders are made.Powder particle is big
Small more uniform, color is uniform.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, are weighed and are calculated hydroscopicity.As a result：Before and after moisture absorption
For appearance without significant change, it is 3.70% to increase weight.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, measure powder flowbility, the front and back flowing of moisture absorption
It is slightly changed, angle of repose is respectively 47.3 ° and 48.4 °
Embodiment 3：
Take 10g HQSMY medicinal extract（1.2g/ml）The compounding auxiliary material that mannitol is mixed with each 50g of L-HPC is at the uniform velocity added
In, it is stirring while adding, until being sufficiently mixed uniformly.Uniformly mixed material tiling is placed in dry 4h, mistake in 80 DEG C of baking oven
HQSMY extract powders are made in sieve.Powder particle size is more uniform, and color is uniform.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, are weighed and are calculated hydroscopicity.As a result：Before and after moisture absorption
For appearance without significant change, it is 4.21% to increase weight.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, measure powder flowbility, the front and back flowing of moisture absorption
Property is almost the same, and angle of repose is each about 33.0 ° or so.
Embodiment 4：
Take 10g HQSMY medicinal extract（1.3g/ml）At the uniform velocity it is added in 50gL-HPC, it is stirring while adding, until being sufficiently mixed
It is even.Uniformly mixed material tiling is placed in dry 4h, sieving in 80 DEG C of baking oven, HQSMY extract powders are made.Powder particle is big
Small more uniform, color is uniform.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, are weighed and are calculated hydroscopicity.As a result：Before and after moisture absorption
For appearance without significant change, it is 11.09% to increase weight.
Above-mentioned sample, in 37 DEG C, RH75% condition lower open mouths are placed 8 hours, measure powder flowbility, the front and back flowing of moisture absorption
It is slightly changed, angle of repose is respectively 40.8 ° and 45.0 °
Above-mentioned embodiment is only a preferred solution of the present invention, not the present invention is made in any form
Limitation, on the premise of not exceeding the technical scheme recorded in the claims also other variations and modifications.
Claims (4)
1. a kind of HUANGQI SHENGMAI YIN extract powder, it is characterised in that：The HUANGQI SHENGMAI YIN extract powder by HUANGQI SHENGMAI YIN medicinal extract with
Appropriate amount of auxiliary materials is uniformly mixed, and is separately won through dry sieve, and the auxiliary material is calcium monohydrogen phosphate, low-substituted hydroxypropyl cellulose, mannitol
In any one or two kinds；The density of the HUANGQI SHENGMAI YIN medicinal extract is 1.1-1.4g/mL, HUANGQI SHENGMAI YIN medicinal extract and auxiliary material
Mass ratio be 1: 2-10.
2. a kind of HUANGQI SHENGMAI YIN extract powder according to claim 1, it is characterised in that：The HUANGQI SHENGMAI YIN medicinal extract
Density is 1.2-1.3g/mL, and the mass ratio of HUANGQI SHENGMAI YIN medicinal extract and auxiliary material is 1: 3-5.
3. a kind of HUANGQI SHENGMAI YIN extract powder according to claim 2, it is characterised in that：The auxiliary material be calcium monohydrogen phosphate,
Arbitrary two kinds of equal proportion mixture in low-substituted hydroxypropyl cellulose, mannitol.
4. a kind of HUANGQI SHENGMAI YIN extract powder according to claim 1 or 2 or 3, it is characterised in that：The HUANGQI SHENGMAI YIN
The preparation method of extract powder is：The HUANGQI SHENGMAI YIN medicinal extract of formula ratio is at the uniform velocity added in the auxiliary material of formula ratio, it is stirring while adding,
Until be sufficiently mixed uniformly, by uniformly mixed material tiling be placed in normal drying device in 80 DEG C or vacuum desiccator in
60 DEG C are dried, that is, are prepared into HUANGQI SHENGMAI YIN extract powder.
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