CN105031093A - Traditional Chinese medicine composition for preventing and controlling stroke and preparation method - Google Patents
Traditional Chinese medicine composition for preventing and controlling stroke and preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for preventing and controlling stroke. The traditional Chinese medicine composition is prepared from, by weight, 10-16 parts of angelica sinensis, 8-13 parts of kamuning roots, 6-12 parts of derris eriocarpa how, 9-14 parts of astragalus membranaceus, 10-15 parts of sweet iris flowers, 6-13 parts of acajounut, 9-15 parts of abrus cantoniensis hance, 8-14 parts of uncaria, 10-13 parts of oenothera stricta, 7-15 parts of populus adenopoda, 9-13 parts of berchemia lineate, 6-15 parts of barbary wolfberry fruits, 8-12 parts of long-stalked kadsura and 7-14 parts of bondia henryi. The traditional Chinese medicine composition has the advantages that the effects of promoting circulation, removing stasis and promoting extravasated blood absorption are achieved, blood vessels of the brain can be effectively expanded, cerebral blood flow is increased, blood and oxygen supplying of the brain tissue is improved, nerve cell function recovery is promoted, and the selected materials are all traditional Chinese medicine materials and are free of any toxic and side effects.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of anti-antapoplectic Chinese medicine composition and method for making.
Background technology
Apoplexy, names of disease of tcm, have exogenous wind and endogenous wind point, exogenous wind, because of caused by being invaded by exogenous pathogen (ailment said due to cold or exposure), says apoplexy (also known as syndrome of decoction GUI ZHI (Ramulus cinnamomi)) in treatise on Febrile Diseases name; Endogenous wind belongs to diseases caused by internal damage, also known as apoplexy, and apoplexy etc.Modern times generally claim apoplexy, refer to the syndrome similar to wind disease of diseases caused by internal damage more, how because QI and blood is inverse disorderly, the resistance of brain BI-syndrome involved the blood vessels or blood oozing from the body openings or subcuta neous tissue be caused by the brain.With unexpected dusk servant, hemiplegia, numb limbs and tense tendons, stiffness of the tongue in silence, crooked mouth and tongue, hemianesthesia etc. are the brain god disease of main manifestations.And there is onset urgency, change soon, as the disease of the feature of ailment said due to cold or exposure benefaction number change.Because primary disease sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high and complication is many, so medical circle is listed as one of three large diseases threatening human health its same coronary heart disease, cancer.
The primary disease cause of disease is more, and from clinical, with endogenous cause of ill, occasioner is in the majority.The generation of apoplexy, is summed up not outer void, fire, wind, expectorant, gas, blood six end.1. feelings will is disgruntled: overaction of the five emotions, heart-fire cruelly very, can priming endogenous wind and send out apoplexy.Clinical is many with rage impairing the liver, and because of rage then extreme hyperactivity of the liver-yang in no time, gas fire is all floating, and forcing blood gushes, and its time must be sent out.Probably sad as troubled thoughts, the nervous inducement being primary disease.2. eating and drinking without temperance: surfeit delicious food pure wine, dysfunction of the spleen in transportation, accumulatively wet raise phlegm, stagnation of phlegm converting into heat, priming liver-wind, folder expectorant is disturbed, can cause a disease and send out, especially bring out the strongest with excessive drinking.3. overwork: " Plain Questions vital QI of the body connecting with natural QI opinion " is said: " yang-energy person, bothers, and opens ", namely refers to personal yang-energy, if disturbance too, then excitedly not hold back.Primary disease also can because managing excessively, and body and the spirit is lost and supported, so that cloudy blood secretly consumes, and empty positive wind-transformation disturbance is for suffering from.Moreover indulge in sensual pleasures wound essence, be also water lose under, hyperactivity of fire in upper, morbidity because of.4. climate change: primary disease all can occur throughout the year, but change relevant with seasonal climate.Entering the winter turns cold suddenly, and cold-evil invades, and can affect blood vessels and follow row.Say as " Plain Questions regulating menstruation opinion " " cold solely to stay, then blood clotting position, solidifying then arteries and veins is obstructed ... ".Secondly suddenly turn early spring when warming up, on the occasion of the main order of chilly wind wood of fainting, planted agent is in liver, and wind sun is dark dynamic, and primary disease also can be caused to occur.5. the blood stasis of blood is stagnant: the formation of blood stasis many because of stagnation of QI hematogenous blockage or deficiency of vital energy fortune blood unable, or to accumulate in upper because of rage blood, or stagnate because feeling cold spasm, or to hinder liquid hematozemia stagnant etc. because of the moon of heat, the pathogenesis of primary disease accumulate mainly with rage blood or blood stasis due to qi deficiency the most common.The traditional Chinese medical science thinks apoplexy often because body is first empty, and negative and positive lose balance, and QI and blood is disorderly inverse, and expectorant stasis blocking is stagnant, caused by limbs mistake is supported.The expectorant stasis of blood is the major pathogenetic factor of primary disease, the stagnant venation of expectorant stasis blocking and cause limbs can not voluntary movement, then suffering limb is skinny for a long time, apathetic.
Application publication number CN103977104A(application number 201410196468.2) Chinese invention patent document disclose a kind of medicine for the treatment of apoplexy, be made up of the raw material of following weight portion: Pheretima 11-14 part, Semen Persicae 6-20 part, Flos Carthami 6-10 part, Radix Angelicae Sinensis 11-15 part, Radix Paeoniae Rubra 11-16 part, Radix Achyranthis Bidentatae 13-16 part, Bombyx Batryticatus 11-18 part, Scorpio 8-13 part, Radix Puerariae 19-24 part.Application publication number CN104000931A(application number 201410244052.3) Chinese invention patent document disclose a kind of medicine for the treatment of apoplexy, be made up of the component of following weight portion: Pheretima 20-30, Radix Paeoniae Rubra 6-12, Radix Ginseng 5-15, Flos Carthami 10-25, Cortex Eucommiae 20-30, blood Scorpio 10-25, Pheretima 3-8, Scolopendra 8-16, Radix Achyranthis Bidentatae 4-10, Radix Rehmanniae Preparata 8-14, Squama Manis 10-18, Radix Puerariae 10-22, Bombyx Batryticatus 6-10, Herba Lycopodii 15-25, Caulis Spatholobi 10-20, Hirudo 20-30, Radix Aconiti Lateralis Preparata 10-20, Radix Astragali 10-20, Radix Glycyrrhizae 4-10, Ramulus Cinnamomi 5-15, Radix Notoginseng powder 10-20, Herba Asari 4-10.Application publication number CN104547545A(application number 201410825891.4) Chinese invention patent document disclose a kind of medicine of prevention of stroke, be made up of the raw material of following parts by weight: Pheretima 10-20 part, Radix Angelicae Sinensis 5-10 part, Radix Puerariae 15-25 part, Radix Paeoniae Rubra 4-10 part, Bombyx Batryticatus 3-8 part, Radix Ginseng 5-15 part, Flos Carthami 10-15 part, Caulis Spatholobi 8-15 part, Scolopendra 10-15 part, Radix Notoginseng 10-20 part, Rhizoma Polygonati Odorati 4-8 part.
Current treatment apoplexy is generally at present by having Western medicine, and side effect is large, and dependency is strong, causes dose increasing, causes vicious cycle.Though existing Chinese medicine untoward reaction is less, onset is slow, and the course for the treatment of is long, poor repeatability.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide one and prepare simply, act on rapidly, prevent antapoplectic Chinese medicine composition safely and effectively.Chinese medicine composition determined curative effect of the present invention, is convenient to Clinical practice.
Technical scheme of the present invention is:
A kind of anti-antapoplectic Chinese medicine composition, is prepared from by following bulk drugs, is weight portion: Radix Angelicae Sinensis 10-16; Radix Murrayae 8-13; Radix Millettiae typicae 6-12; Radix Astragali 9-14; Flos Iridis Chinensis 10-15; Fructus anacardii 6-13; Knot careless 9-15; Ramulus Uncariae Cum Uncis 8-14; Radix Oenotherae Odoratae 10-13; Cortex Populi Adenopodae 7-15; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 9-13; Fructus Lycii 6-15; Caulis Kadsurae Longipedunculatae 8-12; Herba Biondiae henryi 7-14.
In preferred scheme, Radix Angelicae Sinensis 12-14; Radix Murrayae 9.5-11.5; Radix Millettiae typicae 8-10; Radix Astragali 10.5-12.5; Flos Iridis Chinensis 11-14; Fructus anacardii 8-11; Knot careless 11-13; Ramulus Uncariae Cum Uncis 10-12; Radix Oenotherae Odoratae 11-12; Cortex Populi Adenopodae 9-13; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 10-12; Fructus Lycii 8-13; Caulis Kadsurae Longipedunculatae 9-11; Herba Biondiae henryi 9-12.
Be more preferably, Radix Angelicae Sinensis 13; Radix Murrayae 10.5; Radix Millettiae typicae 9; The Radix Astragali 11.5; Flos Iridis Chinensis 12.5; Fructus anacardii 9.5; Knot grass 12; Ramulus Uncariae Cum Uncis 11; Radix Oenotherae Odoratae 11.5; Cortex Populi Adenopodae 11; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 11; Fructus Lycii 10.5; Caulis Kadsurae Longipedunculatae 10; Herba Biondiae henryi 10.5.
A kind of anti-antapoplectic Chinese medicine composition, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Fructus anacardii clean, be placed in parch container, slow fire heat, fry to have detonans and color burn time, taking-up cools, and is together placed in drug ramming pot with Fructus Lycii, smashs into pureed to pieces, for subsequent use;
(2) Flos Iridis Chinensis is cleaned, and the Sucus Zingberis adding 0.15-0.25 times amount is mixed thoroughly (Sucus Zingberis preferably adding 0.2 times amount is mixed thoroughly), and when Sucus Zingberis exhausts, take out, slow fire stir-fries to dark brown and slightly stirs, and dries, grinds into powder, for subsequent use;
(3) get knot grass, Ramulus Uncariae Cum Uncis, Cortex Populi Adenopodae, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore and Herba Biondiae henryi and be placed in baking oven, in 50-60 DEG C of dry 2-4 hour (being preferable over 55 DEG C of dryings 3 hours), taking out, be ground into fine powder, for subsequent use;
(4) Radix Angelicae Sinensis, Radix Murrayae, the Radix Astragali, Radix Millettiae typicae, Radix Oenotherae Odoratae and Caulis Kadsurae Longipedunculatae are placed in Chinese medicament extracting device, take mass fraction as the ethanol of 60-80% be solvent (be preferably the ethanol of 70% with mass fraction be solvent), heating and refluxing extraction twice, reflux, extract, 24-40 minute first time (preferred reflux, extract, for the first time 32 minutes), second time reflux, extract, 16-30 minute (preferably second time reflux, extract, 23 minutes), merge twice alcohol extract, filter, reclaim ethanol, being evaporated to 55 DEG C of relative densities is the clear paste of 1.12-1.15, for subsequent use;
(5) by step (1)-(3) process after crude drug join in above-mentioned clear paste, add while stirring mass fraction be 9.5% sucrose fine and mass fraction be the polyoxyethylene sorbitan monoleate of 7%, mixing, be processed into the pill of Semen Firmianae size, obtain final product.
The preparation method of above-mentioned a kind of anti-antapoplectic medicine pill, preferred scheme is, in step (4), the amount of ethanol is the 6-10 of raw material dose doubly (amount of preferred ethanol is 7-9 times of raw material dose, and the amount of the ethanol be more preferably is 8 times of raw material dose).
The preparation method of described tablet is:
(1) Fructus anacardii is cleaned, and is placed in parch container, and slow fire heats, fry to have detonans and color burn time, taking-up cools, and is together placed in drug ramming pot with Fructus Lycii, smashs into pureed to pieces, fully dry, is ground into fine powder, for subsequent use;
(2) Radix Angelicae Sinensis adds the vinegar of 15% times amount, and soak 12-20 minute (preferably soaking 16 minutes), take out, be together placed in parch container with the Radix Astragali, Radix Millettiae typicae, Radix Murrayae and Radix Oenotherae Odoratae, slow fire heats, and fries to the micro-aobvious coke yellow in surface, takes out, for subsequent use;
(3) by Flos Iridis Chinensis and Herba Biondiae henryi mixing, add the Mel after dilution, wherein the amount of Mel is 0.4-0.6 times (amount of preferred Mel is 0.5 times of raw material dose) of raw material dose, mix thoroughly, slow fire adds to be propagandized hotly to tack-free for spending, taking-up, cool, together be placed in pulverizer with the crude drug after step (2) processes and be ground into fine powder, mixing, for subsequent use;
(4) cramp grass, Ramulus Uncariae Cum Uncis, Cortex Populi Adenopodae, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore and Caulis Kadsurae Longipedunculatae are added clear water and do not have powder, slow fire boiling twice, each respectively decoction 15-25 minute (preferably each each decoction 20 minutes), merges twice decocting liquid, filtration, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.22-1.25, spraying dry, get dry extract powder, cools, porphyrize, for subsequent use;
(5) by the raw material medicated powder mixing after step (1), (3) and (4) process, add dextrin fine powder and sodium lauryl sulphate, sieve, be placed in tablet machine and be pressed into tablet, to obtain final product.
The preparation method of above-mentioned a kind of anti-antapoplectic Chinese medicinal tablet, preferred scheme is, in step (5), the mass ratio of mixed powder and dextrin fine powder and sodium lauryl sulphate is 5:1.1:0.7.
The preparation method of above-mentioned a kind of anti-antapoplectic Chinese medicinal tablet, preferred scheme is, the middle 65-95 mesh sieve excessively of step (5) (preferred 75-85 mesh sieve excessively, mistake 80 mesh sieve be more preferably).
The preparation method of described capsule is:
(1) Fructus anacardii is placed on tile, and smokeless without burning ash, palpus sustainability, cools, porphyrize, for subsequent use; Fructus Lycii is cleaned, and is pounded pureed, is placed in baking oven, fully dry, and porphyrize is for subsequent use;
(2) Flos Iridis Chinensis is placed in parch container, slow fire heating stir-fries 1-3 minute (preferred slow fire heating stir-fries 2 minutes), spray vinegar, wherein the amount of vinegar is 0.15-0.35 times (amount of preferred vinegar is 0.25 times of Flos Iridis Chinensis amount) of Flos Iridis Chinensis amount, continue to stir-fry to coke yellow as spending, taking-up cools, and smashs into fine powder to pieces, for subsequent use;
(3) crude drug except step (1) and (2) is mixed, in 70-80 DEG C of dry 25-45 minute (being preferable over 75 DEG C of dryings 35 minutes), be ground into fine powder, add the clear water slow fire boiling twice clear water slow fire boiling of 6.5 times amount (preferably add twice) of 5-8 times amount, first time decocts 26-48 minute (preferably first time decocts 37 minutes), second time decocts 10-24 minute (preferably second time decocts 17 minutes), merge twice decocting liquid, three layers of cotton cloth filter, it is the thick paste of 1.15-1.20 that filtrate is concentrated into 70 DEG C of relative densities, be cooled to room temperature, add the ethanol that concentration is 80%, ethanol content is made to reach 45%, leave standstill 20-30 hour (preferably leaving standstill 25 hours), filter, distilling under reduced pressure is extremely without alcohol taste, obtain thick paste, for subsequent use,
(4) by step (1) and (2) process after crude drug join in above-mentioned thick paste, mechanical agitation, add while stirring mass fraction be 7% stearic acid and mass fraction be the corn starch of 8.5%, mix homogeneously, granulates, dry, cross No. six sieves, incapsulate shell, to obtain final product.
The preparation method of described water preparation is:
(1) Fructus anacardii and Fructus Lycii mix, and are placed on tile, and smokeless without burning ash, palpus sustainability, cools, porphyrize, for subsequent use;
(2) Radix Angelicae Sinensis, the Radix Astragali, Ramulus Uncariae Cum Uncis and Caulis Kadsurae Longipedunculatae are mixed, the yellow wine being placed in 2.5-4.5 times of raw material dose soaks 15-25 minute (yellow wine being preferably placed in 3.5 times of raw material doses soaks 20 minutes), and take out, slow fire heating fried dry is degree, cools, for subsequent use;
(3) will knot the mixing of grass, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore, Herba Biondiae henryi and Flos Iridis Chinensis, add the Sucus Glycyrrhizae (preferably adding the Sucus Glycyrrhizae of 4.5 times amount) of 4-5 times amount, soaks 1-3 hour (preferably soak 2 hours), take out, slow fire heating fried dry, for spending, cools for subsequent use;
(4) by the crude drug mixing after step (2) and (3) process, add the clear water (preferably adding the clear water of 6 times amount) of 5-7 times amount, slow fire heating decocts 20-30 minute (preferred slow fire heating decoction 25 minutes), and filter, filtrate is for subsequent use;
(5) Radix Millettiae typicae, Radix Murrayae, Radix Oenotherae Odoratae and Cortex Populi Adenopodae are placed in medicine pot, add clear water and do not have powder 3-4cm, big fire is heated to boil, and turns little fire and decocts 32-50 minute (preferably turning little fire to decoct 40 minutes), filter, filtrate and step (4) gained filtrate merge, add step (1) gained raw material medicated powder, continue slow fire boiling 18-30 minute (preferably continuing slow fire boiling 24 minutes), three layers of cotton cloth filter, filtrate is fill after dry heat sterilization, to obtain final product.
Scientific formula of the present invention, preparation method is simple, easy to use, Be very effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component;
2,this not only has blood circulation promoting and blood stasis dispelling, promotes the effect that congestion absorbs, can also expansion of cerebral vascular effectively, and increase cerebral blood flow, improve cerebral tissue blood supply oxygen supply, promote neurocyte functional rehabilitation, selected materials is all Chinese medicine material, without any side effects;
3,medicine of the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1a kind of anti-antapoplectic Chinese medicine composition, is prepared from by following bulk drugs, is weight portion (50g/ part): Radix Angelicae Sinensis 10 parts; Radix Murrayae 8 parts; Radix Millettiae typicae 6 parts; The Radix Astragali 9 parts; Flos Iridis Chinensis 10 parts; Fructus anacardii 6 parts; Knot grass 9 parts; Ramulus Uncariae Cum Uncis 8 parts; Radix Oenotherae Odoratae 10 parts; Cortex Populi Adenopodae 7 parts; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 9 parts; Fructus Lycii 6 parts; Caulis Kadsurae Longipedunculatae 8 parts; Herba Biondiae henryi 7 parts.
A kind of preparation method of anti-antapoplectic medicine pill is:
(1) Fructus anacardii clean, be placed in parch container, slow fire heat, fry to have detonans and color burn time, taking-up cools, and is together placed in drug ramming pot with Fructus Lycii, smashs into pureed to pieces, for subsequent use;
(2) Flos Iridis Chinensis is cleaned, and the Sucus Zingberis adding 0.15 times amount is mixed thoroughly, and when Sucus Zingberis exhausts, take out, slow fire stir-fries to dark brown and slightly stirs, and dries, grinds into powder, for subsequent use;
(3) get knot grass, Ramulus Uncariae Cum Uncis, Cortex Populi Adenopodae, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore and Herba Biondiae henryi and be placed in baking oven, in 50 DEG C of dryings 2 hours, take out, be ground into fine powder, for subsequent use;
(4) Radix Angelicae Sinensis, Radix Murrayae, the Radix Astragali, Radix Millettiae typicae, Radix Oenotherae Odoratae and Caulis Kadsurae Longipedunculatae are placed in Chinese medicament extracting device, take the mass fraction of 6 times of raw material doses as the ethanol of 70% be solvent, heating and refluxing extraction twice, reflux, extract, 32 minutes for the first time, second time reflux, extract, 23 minutes, merges twice alcohol extract, filter, reclaim ethanol, being evaporated to 55 DEG C of relative densities is the clear paste of 1.13, for subsequent use;
(5) by step (1)-(3) process after crude drug join in above-mentioned clear paste, add while stirring mass fraction be 9.5% sucrose fine and mass fraction be the polyoxyethylene sorbitan monoleate of 7%, mixing, be processed into the pill of Semen Firmianae size, obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 8-10 ball, and warm water takes, 7 days courses for the treatment of.
embodiment 2a kind of anti-antapoplectic Chinese medicine composition, is prepared from by following bulk drugs, is weight portion (30g/ part): Radix Angelicae Sinensis 16 parts; Radix Murrayae 13 parts; Radix Millettiae typicae 12 parts; The Radix Astragali 14 parts; Flos Iridis Chinensis 15 parts; Fructus anacardii 13 parts; Knot grass 15 parts; Ramulus Uncariae Cum Uncis 14 parts; Radix Oenotherae Odoratae 13 parts; Cortex Populi Adenopodae 15 parts; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 13 parts; Fructus Lycii 15 parts; Caulis Kadsurae Longipedunculatae 12 parts; Herba Biondiae henryi 14 parts.
A kind of preparation method of anti-antapoplectic Chinese medicinal tablet is:
(1) Fructus anacardii is cleaned, and is placed in parch container, and slow fire heats, fry to have detonans and color burn time, taking-up cools, and is together placed in drug ramming pot with Fructus Lycii, smashs into pureed to pieces, fully dry, is ground into fine powder, for subsequent use;
(2) Radix Angelicae Sinensis adds the vinegar of 15% times amount, soaks 16 minutes, takes out, is together placed in parch container with the Radix Astragali, Radix Millettiae typicae, Radix Murrayae and Radix Oenotherae Odoratae, and slow fire heats, and fries to the micro-aobvious coke yellow in surface, takes out, for subsequent use;
(3) by Flos Iridis Chinensis and Herba Biondiae henryi mixing, add the Mel after dilution, wherein the amount of Mel is 0.5 times of raw material dose, mixes thoroughly, slow fire adds to be propagandized hotly to tack-free for spending, and taking-up, cools, together be placed in pulverizer with the crude drug after step (2) processes and be ground into fine powder, mixing, for subsequent use;
(4) cramp grass, Ramulus Uncariae Cum Uncis, Cortex Populi Adenopodae, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore and Caulis Kadsurae Longipedunculatae are added clear water and do not have powder, slow fire boiling twice, each each decoction 20 minutes, merges twice decocting liquid, filters, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.23, spraying dry, get dry extract powder, cools, porphyrize, for subsequent use;
(5) by the raw material medicated powder mixing after step (1), (3) and (4) process, add dextrin fine powder and sodium lauryl sulphate (mass ratio of mixed powder and dextrin fine powder and sodium lauryl sulphate is 5:1.1:0.7), cross 80 mesh sieves, be placed in tablet machine and be pressed into tablet, to obtain final product.
The instructions of taking of gained tablet of the present invention is: every day three times, each 4-5 sheet, and warm water takes, 7 days courses for the treatment of.
Model case: old XX, man, 53 years old, people from Jining.Patient comes my institute on June 19th, 2010 and checks medical.Patient before one day without obvious inducement occur the right hand and right side face unable, companion's dyslalia to a certain degree, speaks agile, is then promptly sent to my institute by household and checks treatment.Learn through inquiring in detail, once happened suddenly before patient's two weeks right hand spasm, numb, symptom spontaneous remission in a moment.Check: patient's stiff tongue language is stuttering, and limbs are unsuccessful, aversion to cold and cold limbs, shortness of breath and palpitation, vertigo and tinnitus, and blood pressure is on the low side, red tongue is dry or fat tender, and tongue is white, deep-thready pulse.CT examination prompting left side middle cerebral artery occlusion.
Take the anti-antapoplectic Chinese medicinal tablet of the present embodiment gained one, instructions of taking: every day three times, each 4-5 sheet, warm water takes, 7 days courses for the treatment of.After treating two courses for the treatment of, patient's cardinal symptom obviously alleviates, spirit can, sleep good; Again after two courses for the treatment of of continual cure, symptom all disappears, and the right hand and face are without numb and unable sensation, and lab testing symptom recovers normal substantially, and patient's self-induction is fully recovered, and drug withdrawal is followed up a case by regular visits to after half a year, without recurring.
embodiment 3a kind of anti-antapoplectic Chinese medicine composition, is prepared from by following bulk drugs, is weight portion (45g/ part): Radix Angelicae Sinensis 12 parts; Radix Murrayae 9.5 parts; Radix Millettiae typicae 8 parts; The Radix Astragali 10.5 parts; Flos Iridis Chinensis 11 parts; Fructus anacardii 8 parts; Knot grass 11 parts; Ramulus Uncariae Cum Uncis 10 parts; Radix Oenotherae Odoratae 11 parts; Cortex Populi Adenopodae 9 parts; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 10 parts; Fructus Lycii 8 parts; Caulis Kadsurae Longipedunculatae 9 parts; Herba Biondiae henryi 9 parts.
A kind of preparation method of anti-antapoplectic Chinese medicine capsules is:
(1) Fructus anacardii is placed on tile, and smokeless without burning ash, palpus sustainability, cools, porphyrize, for subsequent use; Fructus Lycii is cleaned, and is pounded pureed, is placed in baking oven, fully dry, and porphyrize is for subsequent use;
(2) Flos Iridis Chinensis is placed in parch container, and slow fire heating stir-fries 2 minutes, spray vinegar, and wherein the amount of vinegar is 0.25 times of Flos Iridis Chinensis amount, and continuing to stir-fry to coke yellow is degree, and taking-up cools, and smashs into fine powder to pieces, for subsequent use;
(3) crude drug except step (1) and (2) is mixed, in 75 DEG C of dryings 35 minutes, be ground into fine powder, add the clear water slow fire boiling twice of 6.5 times amount, first time decocts 37 minutes, and second time decocts 17 minutes, merge twice decocting liquid, three layers of cotton cloth filter, and it is the thick paste of 1.18 that filtrate is concentrated into 70 DEG C of relative densities, be cooled to room temperature, add the ethanol that concentration is 80%, make ethanol content reach 45%, leave standstill 25 hours, filter, distilling under reduced pressure is extremely without alcohol taste, obtain thick paste, for subsequent use;
(4) by step (1) and (2) process after crude drug join in above-mentioned thick paste, mechanical agitation, add while stirring mass fraction be 7% stearic acid and mass fraction be the corn starch of 8.5%, mix homogeneously, granulates, dry, cross No. six sieves, incapsulate shell, to obtain final product.
The instructions of taking of gained capsule of the present invention is: every day three times, each 4-6 grain, and warm water takes, 7 days courses for the treatment of.
embodiment 4a kind of anti-antapoplectic Chinese medicine composition, is prepared from by following bulk drugs, is weight portion (35g/ part): Radix Angelicae Sinensis 14 parts; Radix Murrayae 11.5 parts; Radix Millettiae typicae 10 parts; The Radix Astragali 12.5 parts; Flos Iridis Chinensis 14 parts; Fructus anacardii 11 parts; Knot grass 13 parts; Ramulus Uncariae Cum Uncis 12 parts; Radix Oenotherae Odoratae 12 parts; Cortex Populi Adenopodae 13 parts; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 12 parts; Fructus Lycii 13 parts; Caulis Kadsurae Longipedunculatae 11 parts; Herba Biondiae henryi 12 parts.
A kind of preparation method of anti-antapoplectic Chinese medicinal aqua is:
(1) Fructus anacardii and Fructus Lycii mix, and are placed on tile, and smokeless without burning ash, palpus sustainability, cools, porphyrize, for subsequent use;
(2) Radix Angelicae Sinensis, the Radix Astragali, Ramulus Uncariae Cum Uncis and Caulis Kadsurae Longipedunculatae are mixed, the yellow wine being placed in 3.5 times of raw material doses soaks 20 minutes, takes out, and slow fire heating fried dry is degree, cools, for subsequent use;
(3) will knot grass, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore, Herba Biondiae henryi and Flos Iridis Chinensis mixing, add the Sucus Glycyrrhizae of 4.5 times amount, soak 2 hours, take out, slow fire heating fried dry for spend, cool for subsequent use;
(4) by the crude drug mixing after step (2) and (3) process, add the clear water of 6 times amount, slow fire heating decoction 25 minutes, filter, filtrate is for subsequent use;
(5) Radix Millettiae typicae, Radix Murrayae, Radix Oenotherae Odoratae and Cortex Populi Adenopodae are placed in medicine pot, add clear water and do not have powder 3-4cm, big fire is heated to boil, and turns little fire and decocts 40 minutes, filter, filtrate and step (4) gained filtrate merge, add step (1) gained raw material medicated powder, continue slow fire boiling 24 minutes, three layers of cotton cloth filter, filtrate is fill after dry heat sterilization, to obtain final product.
The instructions of taking of gained water preparation of the present invention is: twice daily, each 120-150mL, warmly takes, 7 days courses for the treatment of.
Model case: Song XX, man, 70 years old, people from Linyi.Patient comes my institute on March 28th, 2011 and checks medical.Patient before 2 days on the right side of self-induction face and upper and lower extremities severe unable, numb, acid is swollen, and symptom spontaneous remission after half an hour, face and upper and lower extremities unable symptom occur next day again.Introduce by friend, to our hospital.Patient usually blood pressure is higher, often feels dizziness and headache, lassitude loin and legs.Check: patient's slobbering, dysphasia, Tongue Deviation is trembleed.Red tongue, yellowish fur, stringy,thready and rapid pulse.CT display is without arterial occlusion.In conjunction with patient clinical symptom, be diagnosed as apoplexy.
Take the anti-antapoplectic Chinese medicinal aqua of the present embodiment gained one, instructions of taking: twice daily, each 120-150mL, warmly to take, 7 days courses for the treatment of.After treating two courses for the treatment of, on the right side of patient, limbs are comparatively front strong, and dizziness, lassitude loin and legs obviously alleviate; After two courses for the treatment of of continual cure, right side limb activity is normal, can carry weight, other transference cure, and self-induction is cured.Drug withdrawal is paid a return visit after half a year, and patient body is healthy, without recurrence.
embodiment 5a kind of anti-antapoplectic Chinese medicine composition, is prepared from by following bulk drugs, is weight portion (40g/ part): Radix Angelicae Sinensis 13 parts; Radix Murrayae 10.5 parts; Radix Millettiae typicae 9 parts; The Radix Astragali 11.5 parts; Flos Iridis Chinensis 12.5 parts; Fructus anacardii 9.5 parts; Knot grass 12 parts; Ramulus Uncariae Cum Uncis 11 parts; Radix Oenotherae Odoratae 11.5 parts; Cortex Populi Adenopodae 11 parts; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 11 parts; Fructus Lycii 10.5 parts; Caulis Kadsurae Longipedunculatae 10 parts; Herba Biondiae henryi 10.5 parts.
A kind of preparation method of anti-antapoplectic medicine pill is:
(1) Fructus anacardii clean, be placed in parch container, slow fire heat, fry to have detonans and color burn time, taking-up cools, and is together placed in drug ramming pot with Fructus Lycii, smashs into pureed to pieces, for subsequent use;
(2) Flos Iridis Chinensis is cleaned, and the Sucus Zingberis adding 0.2 times amount is mixed thoroughly, and when Sucus Zingberis exhausts, take out, slow fire stir-fries to dark brown and slightly stirs, and dries, grinds into powder, for subsequent use;
(3) get knot grass, Ramulus Uncariae Cum Uncis, Cortex Populi Adenopodae, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore and Herba Biondiae henryi and be placed in baking oven, in 55 DEG C of dryings 3 hours, take out, be ground into fine powder, for subsequent use;
(4) Radix Angelicae Sinensis, Radix Murrayae, the Radix Astragali, Radix Millettiae typicae, Radix Oenotherae Odoratae and Caulis Kadsurae Longipedunculatae are placed in Chinese medicament extracting device, take the mass fraction of 8 times of raw material doses as the ethanol of 70% be solvent, heating and refluxing extraction twice, reflux, extract, 32 minutes for the first time, second time reflux, extract, 23 minutes, merges twice alcohol extract, filter, reclaim ethanol, being evaporated to 55 DEG C of relative densities is the clear paste of 1.13, for subsequent use;
(5) by step (1)-(3) process after crude drug join in above-mentioned clear paste, add while stirring mass fraction be 9.5% sucrose fine and mass fraction be the polyoxyethylene sorbitan monoleate of 7%, mixing, be processed into the pill of Semen Firmianae size, obtain final product.
The instructions of taking of gained pill of the present invention is: every day three times, each 8-10 ball, and warm water takes, 7 days courses for the treatment of.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Angelicae Sinensis: base is former: this product is the dry root of umbelliferae angelica.Chemical analysis: root is containing volatile oil, and Minxian County, Gansu product person contains 0.7% containing 0.4%, Si Chuanwen county product person.Volatilization main body of oil has: butylidenephthalide, the positive pentanone of adjacent carboxyl benzene and Δ 2,4-dihydro acid phthalic anhydride.Nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Effect: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Cure mainly: for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Radix Murrayae: base is former: the root of rutaceae Folium Et Cacumen Murrayae, autumn adopts, and removes earth, and section, dries.Nature and flavor: " mountain of papers Chinese herbal medicine ": " acrid in the mouth is bitter, warm in nature." return through " Guangxi Chinese medicinal herbal ": " enter the heart, liver, lung three warp." function cures mainly: dispelling the wind and dampness pathogens arthralgia pain, lumbago, traumatic injury, painful and swollen testis, eczema, scabies.
Radix Millettiae typicae: base is former: for leguminous plant dredges root and the leaf of leaf U.S. flower precipice bean rattan.Nature and flavor: sweet; Bitter; Micro-pungent; Property is put down.Gui Jing: Liver Channel.Function cures mainly: dissipating blood stasis for subsidence of swelling; Tonify deficiency is allayed excitement.Main treating swelling and pain by traumatic injury; Rheumatic arthritis; Hemorrhoidal bleeding; Sore swollen toxin; Rubella is itched; Weak after being ill; Dyspepsia.
The Radix Astragali: base is former: this product is the dry root of leguminous plant Radix Astagali or Radix Astragali.Nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Effect: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Cure mainly: weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Flos Iridis Chinensis: base is former: the flower of irides Chinese small iris.Nature and flavor: micro-hardship; Pungent; Micro-sweet; Cold.Gui Jing: return stomach; Spleen; Lung; Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis; Inducing diuresis for treating stranguria syndrome.Main sore throat; Spit blood; Epistaxis; Metrorrhagia; Have blood in stool; Stranguria; Hernia; Hemorrhoid; Carbuncle; Scald.
Fructus anacardii: base is former: medical material Ji Yuan: be the fruit of Anacardiaceae plant chicken Fructus anacardii.Chemical analysis: containing Fructus anacardii acid in shell, Cardanol, Fructus anacardii diphenol, left-handed epicatechin, Fructus anacardii glycoside, purpurein, cupreol.Pharmacological action: kernel is edible, the skin of pit is then irritant.The water extract of bark (lixiviate in 0-5 DEG C of dark environment, invalid after heating) has the effect reduced blood pressure.Nature and flavor: sweet; Flat.Gui Jing: lung meridian.Function cures mainly: nourishing the lung to arrest cough; Quench the thirst; Relieving restlessness.Main cough with dyspnea; Vexed; Thirsty.
Knot grass: base is former: be the herb of the raw Herba stellariae mediae of pinkwort stone.Nature and flavor: pungent; Cool in nature; Mild toxicity.Gui Jing: liver; Spleen channel.Function cures mainly: suppressing the hyperactive liver; Relaxing muscles and tendons to promote blood circulation; Dampness removing; Removing toxic substances.Main aphasia due to apoplexy; Facial hemiparalysis; Numb limbs and tense tendons; Rheumatic arthralgia; Traumatic injury; Icterohepatitis; Leucorrhea; Furuncle.
Ramulus Uncariae Cum Uncis: base is former: be Maguireothamnus speciosus Ramulus Uncariae Cum Uncis or Uncaria sinensis (Oliv.) Havil. and the buckle branch belonging to various plants together thereof.Chemical analysis: stem and branch with belt hook leaf is containing Ramulus Uncariae cum Uncis alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali, hirsutine, hirsuteine.Nature and flavor: sweet are cool.Gui Jing: enter liver, heart channel.Pharmacological action: 1. sedation; 2. hypotensive effect.Function cures mainly: heat clearing away suppressing the hyperactive liver, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Control pediatric epilepsy scared Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclamposia.
Radix Oenotherae Odoratae: base is former: be the root of onagraceae plant Radix Oenotherae Odoratae.Chemical analysis: flower is containing volatile oil.Function cures mainly: " Chinese Higher plant illustrated handbook ": " root is antipyretic.Cure cold, laryngitis.”
Cortex Populi Adenopodae: base is former: be the root bark of Salicaceous Plants Cortex Populi Adenopodae, bark or leaf.Nature and flavor: bitter; Property is put down.Gui Jing: liver; Spleen channel.Function cures mainly: wind-expelling pain-stopping; Promoting blood circulation to remove obstruction in the collateral.Main air pain of dampness syndrome; Extremity are unsuccessful; Dental caries pain; Traumatic blood stasis swells and ache.
Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore: base is former: be the herb of Plants of Polypodiaceae south of the River Microsorium Link band rhizome.Chemical analysis: south of the River Microsorium Link herb is containing triterpenoid: 9 (11)-fernenes, 24-methylene cycloartanol acetas and 24-methylene cycloartane ketone; Also containing uracil, uracil riboside and aesculetin-3-carboxylic acid.Pharmacological action: in vitro tests has obvious inhibitory action to leptospira.Nature and flavor: bitter; Cold.Gui Jing: liver; Spleen; The heart; Lung meridian.Function cures mainly: clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body.Main pyretic stranguria; Dysuria; Leucorrhea with red and white discharge; Dysentery; Jaundice; Hemoptysis; Epistaxis; Bleeding hemorrhoids; Scrofula tuberculosis; Carbuncle sore tumefacting virus; Venom; Rheumatalgia; Injury and bone fracture.
Fructus Lycii: base is former: be the mature fruit of matrimony vine of solanaceae plant or lycium barbarum.Chemical analysis: containing carotene 3.39 milligrams of %, thiamine 0.23 milligram of %, riboflavin 0.33 milligram of %, nicotinic acid 1.7 milligrams of %, ascorbic acid 3 milligrams of % in Fructus Lycii.Still isolate cupreol, linoleic acid.Pharmacological action: 1. lipotropic effect; 2. choline-like effect is intended; Nature and flavor: sweet are flat.Gui Jing: enter liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Caulis Kadsurae Longipedunculatae: base is former: be rattan and the root of Schisandraceae Plant China Fructus Schisandrae Chinensis.Nature and flavor: acid; Warm in nature.Gui Jing: liver, lung, stomach warp.Function cures mainly: relaxing muscles and tendons to promote blood circulation; Regulating QI to relieve pain; Strengthening the spleen to promote digestion; Astringe the lung and promote the production of body fluid.Main traumatic injury; Fracture; Impairment caused by overstrain; Lumbago due to pathogenic wind-dampness; Joint aches; Food stagnation is stagnated; Stomachache; Abdominal distention; Chronic cough is breathed hard; Tianjin is few thirsty; Menoxenia; Bed-wetting; Scald.
Herba Biondiae henryi: base is former: be the whole herb with root of Asclepiadaceae plant biondia hennriyi.Nature and flavor: micro-pungent; Warm in nature.Gui Jing: liver; Kidney channel.Function cures mainly: dispelling wind and removing obstruction in the collateral; Promoting blood circulation and stopping pain.Main anemofrigid-damp arthralgia; Numb limbs and tense tendons cold type of pain; Toothache; Traumatic injury.
test example 1the clinical practice of the anti-antapoplectic Chinese medicine composition of gained one of the present invention and method for making (embodiment 5):
1, data and method
1.1 physical data
In April, 2010, in JIUYUE ,-2013, screened 338 routine paralytics in 4 hospitals, the age 59-73 year, 63.5 ± 3.5 years old mean age, wherein male 185 example, women 153 example; All patients are at the age, and the aspect such as the state of an illness, the course of disease is through statistical procedures, and no significant difference (P > 0.05), has comparability.
1.2 diagnostic criteria
Primary symptom: hemiplegia, god knows unconsciousness, and speech is not smoothgoing puckery or in silence, hemiparesthesia, crooked mouth and tongue.
Secondary disease: headache, dizzy, the refreshing change of pupil, drinking-water is sent out and is choked, order not wink partially, ataxia.
Acute onset, premorbid has inducement more, often has premonitory symptom.Age of onset is many more than 40 years old.
Possessing more than 2 primary symptoms, or 1 primary symptom, 2 diseases, can make a definite diagnosis in conjunction with onset, inducement, premonitory symptom, age; Do not possess above-mentioned condition, also can make a definite diagnosis in conjunction with imaging examination result.
1.3 Therapeutic Method
All patients are divided into experimental group and matched group at random, and experimental group takes products obtained therefrom of the present invention, instructions of taking: every day three times, each 8-10 ball, and warm water takes, 7 days courses for the treatment of.Matched group takes other medicines (as conventional medication such as ZHONGFENG HUICHUN WAN, SANWUJIAO, cow-bezoar bolus for resurrections).Observe four courses for the treatment of of treatment altogether.
1.4 curative effect determinate standard
Cure: clinical symptoms and sign all disappear, and lab testing recovers normal substantially;
Effective: symptomatology is eliminated or cardinal symptom is eliminated, and lab testing significantly improves;
Effective: clinical symptoms is eliminated substantially, lab testing is improved;
Invalid: clinical symptoms and sign is unchanged or comparatively treatment before increase the weight of.
Total effective rate=(cure number of cases+effective number of cases+effectively number of cases) ∕ total inspection case load × 100%.
1.5 therapeutic outcome
The therapeutic outcome of two groups of patients, as shown in table 1:
Table 1: the therapeutic outcome of experimental group and matched group patient compares
Therapeutic effect: experimental group cures 154 examples (70%), effective 47 examples (21.4%), effective 14 examples (6.3%), invalid 5 examples (2.3%), total effective rate 97.7%.From result, experimental group therapeutic effect is obviously better than matched group.
The present invention select Radix Angelicae Sinensis, Radix Murrayae, Radix Millettiae typicae, the Radix Astragali, Flos Iridis Chinensis, Fructus anacardii, cramp grass, Ramulus Uncariae Cum Uncis, Radix Oenotherae Odoratae and Cortex Populi Adenopodae etc. totally 14 taste primary raw material medicines be prepared from.Fang Zhong, Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation; Radix Millettiae typicae tonify deficiency is allayed excitement; Radix Astragali invigorating QI to consolidate the body surface resistance, diuresis poison holding; Flos Iridis Chinensis heat-clearing and toxic substances removing, cooling blood for hemostasis; Fructus anacardii quenches the thirst relieving restlessness; Knot careless relaxing muscles and tendons to promote blood circulation; Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion; Cortex Populi Adenopodae wind-expelling pain-stopping, promoting blood circulation to remove obstruction in the collateral; Fructus Lycii nourishing kidney, lung moistening, tonifying liver, improving eyesight; Herba Biondiae henryi dispelling wind and removing obstruction in the collateral.All medicines share, altogether long memorial wind dampness removing, channels sootheing and network vessel quickening, effect of promoting blood circulation and stopping pain.After treating four courses for the treatment of, treatment group effective percentage can reach 97.7%, and matched group is only 78.8%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. an anti-antapoplectic Chinese medicine composition, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Angelicae Sinensis 10-16; Radix Murrayae 8-13; Radix Millettiae typicae 6-12; Radix Astragali 9-14; Flos Iridis Chinensis 10-15; Fructus anacardii 6-13; Knot careless 9-15; Ramulus Uncariae Cum Uncis 8-14; Radix Oenotherae Odoratae 10-13; Cortex Populi Adenopodae 7-15; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 9-13; Fructus Lycii 6-15; Caulis Kadsurae Longipedunculatae 8-12; Herba Biondiae henryi 7-14.
2. a kind of anti-antapoplectic Chinese medicine composition as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Angelicae Sinensis 12-14; Radix Murrayae 9.5-11.5; Radix Millettiae typicae 8-10; Radix Astragali 10.5-12.5; Flos Iridis Chinensis 11-14; Fructus anacardii 8-11; Knot careless 11-13; Ramulus Uncariae Cum Uncis 10-12; Radix Oenotherae Odoratae 11-12; Cortex Populi Adenopodae 9-13; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 10-12; Fructus Lycii 8-13; Caulis Kadsurae Longipedunculatae 9-11; Herba Biondiae henryi 9-12.
3. a kind of anti-antapoplectic Chinese medicine composition as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Radix Angelicae Sinensis 13; Radix Murrayae 10.5; Radix Millettiae typicae 9; The Radix Astragali 11.5; Flos Iridis Chinensis 12.5; Fructus anacardii 9.5; Knot grass 12; Ramulus Uncariae Cum Uncis 11; Radix Oenotherae Odoratae 11.5; Cortex Populi Adenopodae 11; Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore 11; Fructus Lycii 10.5; Caulis Kadsurae Longipedunculatae 10; Herba Biondiae henryi 10.5.
4. the one as described in claim 1-3 prevents antapoplectic Chinese medicine composition, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Fructus anacardii clean, be placed in parch container, slow fire heat, fry to have detonans and color burn time, taking-up cools, and is together placed in drug ramming pot with Fructus Lycii, smashs into pureed to pieces, for subsequent use;
(2) Flos Iridis Chinensis is cleaned, and the Sucus Zingberis adding 0.15-0.25 times amount is mixed thoroughly (Sucus Zingberis preferably adding 0.2 times amount is mixed thoroughly), and when Sucus Zingberis exhausts, take out, slow fire stir-fries to dark brown and slightly stirs, and dries, grinds into powder, for subsequent use;
(3) get knot grass, Ramulus Uncariae Cum Uncis, Cortex Populi Adenopodae, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore and Herba Biondiae henryi and be placed in baking oven, in 50-60 DEG C of dry 2-4 hour (being preferable over 55 DEG C of dryings 3 hours), taking out, be ground into fine powder, for subsequent use;
(4) Radix Angelicae Sinensis, Radix Murrayae, the Radix Astragali, Radix Millettiae typicae, Radix Oenotherae Odoratae and Caulis Kadsurae Longipedunculatae are placed in Chinese medicament extracting device, take mass fraction as the ethanol of 60-80% be solvent (be preferably the ethanol of 70% with mass fraction be solvent), heating and refluxing extraction twice, reflux, extract, 24-40 minute first time (preferred reflux, extract, for the first time 32 minutes), second time reflux, extract, 16-30 minute (preferably second time reflux, extract, 23 minutes), merge twice alcohol extract, filter, reclaim ethanol, being evaporated to 55 DEG C of relative densities is the clear paste of 1.12-1.15, for subsequent use;
(5) by step (1)-(3) process after crude drug join in above-mentioned clear paste, add while stirring mass fraction be 9.5% sucrose fine and mass fraction be the polyoxyethylene sorbitan monoleate of 7%, mixing, be processed into the pill of Semen Firmianae size, obtain final product.
5. the preparation method of a kind of anti-antapoplectic medicine pill according to claim 4, it is characterized in that, in step (4), the amount of ethanol is the 6-10 of raw material dose doubly (amount of preferred ethanol is 7-9 times of raw material dose, and the amount of the ethanol be more preferably is 8 times of raw material dose).
6. the one as described in claim 1-3 prevents antapoplectic Chinese medicine composition, it is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Fructus anacardii is cleaned, and is placed in parch container, and slow fire heats, fry to have detonans and color burn time, taking-up cools, and is together placed in drug ramming pot with Fructus Lycii, smashs into pureed to pieces, fully dry, is ground into fine powder, for subsequent use;
(2) Radix Angelicae Sinensis adds the vinegar of 15% times amount, and soak 12-20 minute (preferably soaking 16 minutes), take out, be together placed in parch container with the Radix Astragali, Radix Millettiae typicae, Radix Murrayae and Radix Oenotherae Odoratae, slow fire heats, and fries to the micro-aobvious coke yellow in surface, takes out, for subsequent use;
(3) by Flos Iridis Chinensis and Herba Biondiae henryi mixing, add the Mel after dilution, wherein the amount of Mel is 0.4-0.6 times (amount of preferred Mel is 0.5 times of raw material dose) of raw material dose, mix thoroughly, slow fire adds to be propagandized hotly to tack-free for spending, taking-up, cool, together be placed in pulverizer with the crude drug after step (2) processes and be ground into fine powder, mixing, for subsequent use;
(4) cramp grass, Ramulus Uncariae Cum Uncis, Cortex Populi Adenopodae, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore and Caulis Kadsurae Longipedunculatae are added clear water and do not have powder, slow fire boiling twice, each respectively decoction 15-25 minute (preferably each each decoction 20 minutes), merges twice decocting liquid, filtration, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.22-1.25, spraying dry, get dry extract powder, cools, porphyrize, for subsequent use;
(5) by the raw material medicated powder mixing after step (1), (3) and (4) process, add dextrin fine powder and sodium lauryl sulphate, sieve, be placed in tablet machine and be pressed into tablet, to obtain final product.
7. the preparation method of a kind of anti-antapoplectic Chinese medicinal tablet according to claim 6, it is characterized in that, in step (5), the mass ratio of mixed powder and dextrin fine powder and sodium lauryl sulphate is 5:1.1:0.7.
8. the preparation method of a kind of anti-antapoplectic Chinese medicinal tablet according to claim 6, is characterized in that, the middle 65-95 mesh sieve excessively of step (5) (preferred 75-85 mesh sieve excessively, mistake 80 mesh sieve be more preferably).
9. the one as described in claim 1-3 prevents antapoplectic Chinese medicine composition, it is characterized in that, be made into pharmaceutically acceptable capsule, preparation method is as follows:
(1) Fructus anacardii is placed on tile, and smokeless without burning ash, palpus sustainability, cools, porphyrize, for subsequent use; Fructus Lycii is cleaned, and is pounded pureed, is placed in baking oven, fully dry, and porphyrize is for subsequent use;
(2) Flos Iridis Chinensis is placed in parch container, slow fire heating stir-fries 1-3 minute (preferred slow fire heating stir-fries 2 minutes), spray vinegar, wherein the amount of vinegar is 0.15-0.35 times (amount of preferred vinegar is 0.25 times of Flos Iridis Chinensis amount) of Flos Iridis Chinensis amount, continue to stir-fry to coke yellow as spending, taking-up cools, and smashs into fine powder to pieces, for subsequent use;
(3) crude drug except step (1) and (2) is mixed, in 70-80 DEG C of dry 25-45 minute (being preferable over 75 DEG C of dryings 35 minutes), be ground into fine powder, add the clear water slow fire boiling twice clear water slow fire boiling of 6.5 times amount (preferably add twice) of 5-8 times amount, first time decocts 26-48 minute (preferably first time decocts 37 minutes), second time decocts 10-24 minute (preferably second time decocts 17 minutes), merge twice decocting liquid, three layers of cotton cloth filter, it is the thick paste of 1.15-1.20 that filtrate is concentrated into 70 DEG C of relative densities, be cooled to room temperature, add the ethanol that concentration is 80%, ethanol content is made to reach 45%, leave standstill 20-30 hour (preferably leaving standstill 25 hours), filter, distilling under reduced pressure is extremely without alcohol taste, obtain thick paste, for subsequent use,
(4) by step (1) and (2) process after crude drug join in above-mentioned thick paste, mechanical agitation, add while stirring mass fraction be 7% stearic acid and mass fraction be the corn starch of 8.5%, mix homogeneously, granulates, dry, cross No. six sieves, incapsulate shell, to obtain final product.
10. the one as described in claim 1-3 prevents antapoplectic Chinese medicine composition, it is characterized in that, be made into pharmaceutically acceptable water preparation, preparation method is as follows:
(1) Fructus anacardii and Fructus Lycii mix, and are placed on tile, and smokeless without burning ash, palpus sustainability, cools, porphyrize, for subsequent use;
(2) Radix Angelicae Sinensis, the Radix Astragali, Ramulus Uncariae Cum Uncis and Caulis Kadsurae Longipedunculatae are mixed, the yellow wine being placed in 2.5-4.5 times of raw material dose soaks 15-25 minute (yellow wine being preferably placed in 3.5 times of raw material doses soaks 20 minutes), and take out, slow fire heating fried dry is degree, cools, for subsequent use;
(3) will knot the mixing of grass, Microsorium fortunei (Moore) Ching [Drynaria fortunei Moore, Herba Biondiae henryi and Flos Iridis Chinensis, add the Sucus Glycyrrhizae (preferably adding the Sucus Glycyrrhizae of 4.5 times amount) of 4-5 times amount, soaks 1-3 hour (preferably soak 2 hours), take out, slow fire heating fried dry, for spending, cools for subsequent use;
(4) by the crude drug mixing after step (2) and (3) process, add the clear water (preferably adding the clear water of 6 times amount) of 5-7 times amount, slow fire heating decocts 20-30 minute (preferred slow fire heating decoction 25 minutes), and filter, filtrate is for subsequent use;
(5) Radix Millettiae typicae, Radix Murrayae, Radix Oenotherae Odoratae and Cortex Populi Adenopodae are placed in medicine pot, add clear water and do not have powder 3-4cm, big fire is heated to boil, and turns little fire and decocts 32-50 minute (preferably turning little fire to decoct 40 minutes), filter, filtrate and step (4) gained filtrate merge, add step (1) gained raw material medicated powder, continue slow fire boiling 18-30 minute (preferably continuing slow fire boiling 24 minutes), three layers of cotton cloth filter, filtrate is fill after dry heat sterilization, to obtain final product.
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| CN201510544382.9A CN105031093A (en) | 2015-08-31 | 2015-08-31 | Traditional Chinese medicine composition for preventing and controlling stroke and preparation method |
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| CN101611863A (en) * | 2008-06-26 | 2009-12-30 | 陈梅 | Health-care seven-flavor drink for middle-aged and old people |
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| CN101611863A (en) * | 2008-06-26 | 2009-12-30 | 陈梅 | Health-care seven-flavor drink for middle-aged and old people |
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Address after: The new road 553000 in Guizhou province Liupanshui City Zhongshan District No. 20 Sichuan heart District 1 building 3-202 Applicant after: Li Yuxin Address before: Beiyuan Street Licheng District 250000 Shandong city of Ji''nan province No. 26 Applicant before: Li Yuxin |
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Application publication date: 20151111 |