CN105012539A - External application traditional Chinese medicine blood pressure stabilizing paste ointment capable of replacing oral medicine, and applications thereof - Google Patents
External application traditional Chinese medicine blood pressure stabilizing paste ointment capable of replacing oral medicine, and applications thereof Download PDFInfo
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- CN105012539A CN105012539A CN201410152215.5A CN201410152215A CN105012539A CN 105012539 A CN105012539 A CN 105012539A CN 201410152215 A CN201410152215 A CN 201410152215A CN 105012539 A CN105012539 A CN 105012539A
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Abstract
The present invention discloses an external application traditional Chinese medicine blood pressure stabilizing paste ointment capable of replacing oral medicine, and applications thereof, wherein the blood pressure stabilizing paste ointment comprises an ointment part and a liquid part, and the bulk drugs in the formula of the blood pressure stabilizing paste ointment comprise 6-12 g of semen cassiae, 6-12 g of codonopsis pilosula, 6-12 g of milkvetch root, 6-12 g of angelica, 6-12 g of mulberry twig, 6-12 g of fructus aurantii, 6-12 g of radix linderae, 6-15 g of cynanchum otophyllum, 6-15 g of achyranthes bidentata, 6-15 g of fructus viticis, 6-15 g of tribulus terrestris, 6-15 g of eucommia ulmoides, 18-24 g of radix angelicae pubescentis, 3-8 g of cape jasmine, and 3-8 g of asarum sieboldii miq. According to the present invention, the bulk drugs for preparing the traditional Chinese medicine composition of the present invention have characteristics of rational compatibility and mutual coordination, such that the blood free radicals and the blood vessel deposits can be removed and the vascular toughness can be increased so as to provide the blood pressure stabilizing effect; and the blood pressure stabilizing paste ointment has characteristics of easy use, no toxic-side effect, good effect on essential hypertension and stable and durable blood pressure reducing, and is easily accepted by patients.
Description
Technical field
The present invention relates to a kind of ointment, particularly a kind of voltage stabilizing adhesive plaster and application thereof substituting the external application Chinese medicine of taking medicine.
Background technology
Hypertension is a kind of commonly encountered diseases and frequently-occurring disease.This sick general onset is slow, patient is early stage often asymptomatic, or only have the symptoms such as dizziness, headache, cardiopalmus, tinnitus, one independently disease outwardly, malpractice is actually and causes the important risk factor of the heart, cerebrovascular and nephropathy one, if pathological changes will become these common hypertension complications such as more serious apoplexy, myocardial infarction and renal failure.
For a long time, treatment hypertension must use oral medicine for a long time in a large number, and some oral drugs are general just there is the shortcomings such as dosage is large, onset is slow, side effect is large, simultaneously because oral medicine drug effect can not be lasting, especially in morning,---in hypertensive patient is the most dangerous---drug effect decays, although Here it is, a lot of hypertensive patient adheres to taking medicine, but still occurs the main cause of " sudden death in morning ".Doctor and patient all urgently wishes to find that good effect, effective time are long, dosage is little, side effect is little, the medicine of low cost for this reason.In addition oral drugs are large to the intestines and stomach damage, and long-time oral drugs can affect other functions of health, and side effect is large.
Summary of the invention
The invention provides and a kind ofly substitute the voltage stabilizing adhesive plaster of external application Chinese medicine and application thereof of taking medicine, the voltage stabilizing adhesive plaster of Chinese medicine of the present invention is easy to use, have no side effect, effective to essential hypertension.
For achieving the above object, the present invention is achieved by the following technical solutions:
A kind of voltage stabilizing adhesive plaster substituting the external application Chinese medicine of taking medicine, this voltage stabilizing adhesive plaster is made up of mastic part and liquid part, and voltage stabilizing adhesive plaster crude drug formula consists of: Semen Cassiae 6-12 gram, Radix Codonopsis 6-12 gram, Radix Astragali 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Ramulus Mori 6-12 gram, Fructus Aurantii 6-12 gram, Radix Linderae 6-12 gram, Radix Paeoniae Alba 6-15 gram, Radix Achyranthis Bidentatae 6-15 gram, Fructus Viticis 6-15 gram, Fructus Atriplicis Sibiricae 6-15 gram, Cortex Eucommiae 6-15 gram, Radix Angelicae Pubescentis 18-24 Ke, Gardenia 3-8 gram, Herba Asari 3-8 gram.
Preferably, liquid part preparation method be by the prescription of Chinese medicine take Semen Cassiae 6-12 gram, Radix Codonopsis 6-12 gram, Radix Astragali 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Ramulus Mori 6-12 gram, Fructus Aurantii 6-12 gram, Radix Linderae 6-12 gram, Radix Paeoniae Alba 6-15 gram, Radix Achyranthis Bidentatae 6-15 gram, Fructus Viticis 6-15 gram, Fructus Atriplicis Sibiricae 6-15 gram, Cortex Eucommiae 6-15 gram, Radix Angelicae Pubescentis 18-24 Ke, Gardenia 3-8 gram, Herba Asari 3-8 gram, after co-grinding powder A; Powder A and solvent are loaded extractor, extracts to obtain suspension, filter, melt cinder is separated to obtain extracting solution I and residue I; Residue I and solvent are loaded extractor, extracts, the mixture after extraction filters, and obtains extract II; Extract I and extract II is mixed to get mixed liquor, and distilling under reduced pressure obtains the liquid part that product is voltage stabilizing adhesive plaster.
More preferably, solvent formula consists of: 95% ethanol 6g, glycerol 2g, propylene glycol 1g, water 1g.
Preferably, voltage stabilizing adhesive plaster using method, for getting liquid part 2 in mastic part, pastes Yongquan acupoint.
Beneficial effect: for the preparation of the crude drug of Chinese medicine composition of the present invention, compatibility is rationally worked in coordination with mutually, can play maximum effect, can play and remove the free radical of blood and the deposit of blood vessel, increases blood vessel Tough, thus plays the effect of stabilizing blood pressure.Through Long-term clinical checking, by sticking in Yongquan acupoint, treated in vitro, can dredging the meridian, nurses one's health hepatic and renal function comprehensively, corrects the blood pressure regulating mechanisms of human body, removes blood vessel deposit, vessel softening, increases Strong Xue Guan Tough; Remove the free radical in blood, improve blood matter, recover blood normal flow, flow, make blood pressure steady.Eliminate headache, dizziness, insomnia, forgetful, the cardiopalmus caused by hypertension, hyperlipidemia, the disease such as weak, irritable, xerostomia dry pharynx, stiffness of the neck, numbness of hands and feet, face, foot edema, face, lip are dark and gloomy, and contribute to apoplexy, the rehabilitation of hemiplegia, safety has no toxic and side effects, consumption is few, cost saving.Blood pressure lowering is steadily, lastingly, easy for patients to accept.
Detailed description of the invention
Each taste raw material of Chinese medicine effect of the present invention is as follows:
Semen Cassiae [function cures mainly] Semen Cassiae is containing emodin (emodin), chrysophanol (chrysophanol), physcione (physcion), obtusin (obtusin), obtusin (obtusifolin) and glycoside thereof.There are blood pressure lowering, blood fat reducing, antiplatelet aggregative activity.For the puckery pain of conjunctival congestion, the many tear of photophobia, have a headache dizzy, poor vision, loosening bowel to relieve constipation.
Radix Codonopsis [function cures mainly] Radix Codonopsis is containing various saccharides, phenols, sterol, volatile oil, scutellarein glucosid, Saponin and Alkaloid.There is enhancing immunity, blood vessel dilating, blood pressure lowering, improve microcirculation, strengthen the effects such as hemopoietic function.
The Radix Astragali [function cures mainly] Radix Astragali is containing the various trace elements such as Saponin, sucrose, polysaccharide, several amino acids, folic acid and selenium, zinc, copper.There is enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Radix Angelicae Sinensis [function cures mainly] Radix Angelicae Sinensis, containing volatile oil composition and organic acid, is mainly succinic acid, Yan acid, uracil, adenine, ligustilide, vitamin B12, vitamin E, sitoesterol, folinic acid, butylidenephthalide, ferulic acid etc.There is the effect of antioxidation and scavenging free radicals, have the effect of vitamin antagonist E deficiency disease.The irritability of cardiac muscle can be reduced, human atrial fiber is trembled and has therapeutical effect.Simultaneously to the shrinkage amplitude of heart and frequency all in suppression.Can reduce blood pressure, blood fat slightly declines, and has protective effect to aortal pathological changes.Certain effect is had to atherosclerosis.
Ramulus Mori [function cures mainly] Ramulus Mori is containing I-deoxynojirimycin----Sang enzyme element.Ramulus Mori can only be quenched one's thirst, improving eyesight long hair.Its property bitter but sweet flavor, cold, sweet so beneficial blood, cold so removing heat from blood, to be sweetly coldly harmonious, again can improving eyesight and cough-relieving, there is the merit of tonification.Dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.
Fructus Aurantii [function cures mainly] is containing citronin (poncirin), naringin (naringin), citrifolioside (citrifolioside), citrusin (poncimarin), different citrusin (isoponcimarin).Regulating the flow of QI to ease the stomach, the stagnant relieving distension of row, clearing heat and moistening lung, laxation relieving constipation, accelerates blood circulation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.
The Radix Linderae [function cures mainly] is containing multiple sesquiterpenoids composition lindestrene (lindestrene), lindestrenolide (lindestreno-lide), hydroxylindestrenolide, l-borneol (linderenol), linderoxide (linderoxide), isolinderoxide (isolind-eroxide), linderenone (linderenone).Pleasant pain relieving, warming kidney for dispelling cold.For chest and abdomen swelling and pain, QI rising in reverse order dyspnea with rapid respiration, deficiency-cold in the urinary bladder, enuresis frequent micturition, hernia, dysmenorrhea, local is coated with the blood circulation that can distend the blood vessels, accelerate, alleviates composite muscle spasmic pain.
The Radix Paeoniae Alba [function cures mainly] is containing white peony root's total glycoside (total glucosides of paeonia, TGP) be the general name of paeoniflorin (paeoniflorin), hydroxypaeoniflorin (hydroxy-paeoniflorin), paeoniflorin (paeonin), Albiflorin (albiflorin), benzoylpaeoniflorin (benzoylpaeoniflorin), be called for short TGP.Effect blood vessel dilating effect to the heart and cerebrovascular system: paeoniflorin energy coronary artery dilator, increases coronary flow, and antagonism acute myocardial ischemia, reduces blood pressure.Antithrombotic effect. lipidemia effect.Have spasmolysis, it is certain immunoloregulation function that peoniflorin has.To the effect of central nervous system, paeoniflorin has significant analgesia, calmness, anticonvulsant action.
Radix Achyranthis Bidentatae [function cures mainly] Radix Achyranthis Bidentatae contains Analysis of Steroids and the polysaccharide composition such as triterpene saponin (becoming oleanolic acid and sugar after hydrolysis), ecdysterone, inokosterone, rubrosterone.In addition, Radix Achyranthis Bidentatae is also containing 12 swollen aminoacid and alkaloids, the compounds such as Coumarins and trace element such as ferrum, copper such as arginine.Invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, dizziness due to hyperactivity of liver-YANG.
Fructus Viticis [function cures mainly] Vitex rotundifolia fruit and leaf are containing volatile oil, and main component is camphene (Camphene) and pinene (Pinene), and containing Alkaloid and vitamin A; Still containing Fructus Viticis Cannabifoliae flavone (Vitexicarpin), i.e. pale reddish brown Herba Viticis Cannabifoliae in fruit.Element (Casticin).Wild pepper fruit is containing a small amount of (0.01%) vitricin (Vitricin).Fruit is containing volatile oil about 0.16%, and in oil, main constituent is camphene and pinene.In addition, still containing vitex negundo (5,3 '-dihydroxy-3,6,7,4 '-tetramethoayflavone, vitexicarpin, casticin) and γ-aminobutyric acid (γ-aminobutyric acid) and fatty oil about 6.1%.Seed is containing artemetine (5-hydroxy-3,6,7,3 ', 4 '-pentamethoayflavone, artemetin) and vitex negundo.Pungent and cold medicine for relieving the exterior syndrome, has blood pressure lowering, antalgic and inflammation relieving, dispelling wind and heat pathogens, effect of the clear sharp head.Dispelling wind and heat pathogens, the clear sharp head.Control anemopyretic cold, just, migraine, tooth disease, acute conjunctivitis, pain in order eyeball, dim many tear, arthralgia chiefly caused by damp pathogen contracture.
Fructus Atriplicis Sibiricae [function cures mainly] is containing steroid saponin, its ruscogenin is diosgenin (diosgenin), ruscogenin (ruscogenin), gitogenin (gitoogenin), Fructus Tribuli glycoside (tribuloside), Kaempferol-rutinoside (kaempferol-3-rutinoside), astragalin (astragalin), flavone.There is blood pressure lowering, blood fat reducing, antiinflammatory, the sclerosis of anti-tremulous pulse medicated porridge, defying age, antitumor, anticoagulant, analgesia, resisting fatigue, tonifying the kidney to consolidate the essence, the effect of nourishing the liver to improve visual acuity.
The Cortex Eucommiae [function cures mainly], containing gutta-percha, Pinoresinol diglucoside, kaempferol, eucommito, ajugoside, reptoside, harpagide acetic acid fat, galactitol, also has some trace element zincs, copper, ferrum, calcium, phosphorus, manganese, lead etc. in addition.There are antibacterial, antiinflammatory, removing toxic substances, function of gallbladder promoting, blood pressure lowering, blood fat reducing, the sclerosis of anti-tremulous pulse medicated porridge, invigorating the liver and kidney, bone and muscle strengthening effect.Invigorating the liver and kidney, bone and muscle strengthening, antiabortive., blood leaking in gestation, frequent fetal movement, hypertension unable for lumbago due to renal deficiency, muscles and bones.
Radix Angelicae Pubescentis [function cures mainly] is containing bergapton (bergapten), dihydro mountain celery Radix Angelicae Sinensis grease (columbianadin), columbianetin (columbianetin), o-acetylcolumbianetin, umbrella flower lactone (umbelliferone), angelol A-H(angelolA-H) and the multiple Coumarins compound such as scopletin.Expelling wind and removing dampness, arthralgia aggravated by cold pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.There are antiinflammatory, analgesia and sedation; Inhibitory action is had to platelet aggregation; And it is not have hypotensive effect, but lasting.
Gardenia [function cures mainly] is containing multiple iridoid glycoside constituents, be mainly gardenoside, i.e. genipin l-glycoside, content up to 6%, and contains geniposide, genipin-1-β-gentiobiose glycoside, fevervine time glycoside methyl ester, gardoside, Fructus Gardeniae ketone glycoside, deacetylasperulosidic acid methyl ester etc.; Another containing crocin, bayer acid, ursolic acid etc.Have hypotensive effect, blood pressure lowering is rapid, holds time of short duration.After preventing and treating atherosclerosis and anti thrombotic action blood vessel injury, the retardance of endothelial cell growth can cause atherosclerosis and thrombosis calmness, antiinflammatory and treatment soft tissue injury anti-microbial effect function of gallbladder promoting, acute pancreatitis, this is to the oxidation resistance safeguarding body self, and hepatoprotective effect.
Herba Asari [function cures mainly] is containing volatile oil, main containing methyleugenol (methyleugenol) in oil.Another containing asaricin (asaricin), elemicin.Diaphoretic medicine is sensible, expelling wind and cold, understand things pain-stopping, warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Voltage stabilizing adhesive plaster of the present invention is made up of mastic part and liquid part, and voltage stabilizing adhesive plaster crude drug formula consists of: Semen Cassiae 6-12 gram, Radix Codonopsis 6-12 gram, Radix Astragali 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Ramulus Mori 6-12 gram, Fructus Aurantii 6-12 gram, Radix Linderae 6-12 gram, Radix Paeoniae Alba 6-15 gram, Radix Achyranthis Bidentatae 6-15 gram, Fructus Viticis 6-15 gram, Fructus Atriplicis Sibiricae 6-15 gram, Cortex Eucommiae 6-15 gram, Radix Angelicae Pubescentis 18-24 Ke, Gardenia 3-8 gram, Herba Asari 3-8 gram.
Liquid part preparation method be by the prescription of Chinese medicine take Semen Cassiae 6-12 gram, Radix Codonopsis 6-12 gram, Radix Astragali 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Ramulus Mori 6-12 gram, Fructus Aurantii 6-12 gram, Radix Linderae 6-12 gram, Radix Paeoniae Alba 6-15 gram, Radix Achyranthis Bidentatae 6-15 gram, Fructus Viticis 6-15 gram, Fructus Atriplicis Sibiricae 6-15 gram, Cortex Eucommiae 6-15 gram, Radix Angelicae Pubescentis 18-24 Ke, Gardenia 3-8 gram, Herba Asari 3-8 gram, after co-grinding powder A; Powder A and solvent are loaded extractor, extracts to obtain suspension, filter, melt cinder is separated to obtain extracting solution I and residue I; Residue I and solvent are loaded extractor, extracts, the mixture after extraction filters, and obtains extract II; Extract I and extract II is mixed to get mixed liquor, and distilling under reduced pressure obtains the liquid part that product is voltage stabilizing adhesive plaster.
Solvent formula consists of: 95% ethanol 6g, glycerol 2g, propylene glycol 1g, water 1g.
Voltage stabilizing adhesive plaster using method, for getting liquid part 2 in mastic part, pastes Yongquan acupoint.Every night with little voltage stabilizing adhesive plaster, be affixed on a sufficient Yongquan acupoint, namely left and right is pasted in turn and is namely stopped to take medicine, and paste everyday and replace taking medicine everyday, blood pressure is steady.Below by way of actual clinical case, effect of the present invention is described.
Clinical case:
Case 1:
Chan xx, female, 70 years old now, Quanzhou university retired professor .2010 JIUYUE brings into use voltage stabilizing adhesive plaster of the present invention (being called for short voltage stabilizing adhesive plaster once), blood pressure is down to 120/70 from 173/90, and 1-2 days about 140/75 once in a while, never eats medicine so far, once stopped to paste voltage stabilizing and paste 40 days, blood pressure stabilization is about 140/70.Continue to use steady blood pressure note, blood pressure stabilization is at 120-130/70-75.
Case 2:
Land xx, female, 72 years old now, Xiamen hospital retirement doctor.On May 5th, 2013 brings into use voltage stabilizing adhesive plaster, and blood of originally taking medicine can fall, and blood pressure is 160/110, and stomach of taking medicine be can't stand, uses steady blood pressure to paste, and pastes 4 days blood pressures and is down to 120/70.Often within 2-3 days, paste one time now, No ate blood pressure lowering Chinese medicine and western medicine again, and blood pressure remains on about 130/70 basicly stable, and the edema of foot also disappears, now still at subsides blood pressure stabilization.
Case 3:
Clock xx, man, 70 years old, former the Ministry of Chemical Industry the Head of Office in Xiamen retirement, by taking medicine control blood pressure before on August 5th, 2013, used voltage stabilizing adhesive plaster that night, August 6 just stopped to have taken medicine, and blood pressure remains on 120/70 scope always so far, and change a couple of days is 140/70 once in a while.
Case 4:
Yellow xx, female, 74 years old, Xiamen plant personnel. suffer from diabetes and cause hypertension, on July 10th, 2013 uses voltage stabilizing adhesive plaster, blood pressure remains on about 140/75 always, and have several days because feeling blue, difficulty is fallen asleep, blood pressure rises to 170/85, in a good humor, sleep is normal, and blood pressure still remains on about 140/75.
Case 5:
Retired teacher's flood xx in Yongchun, Quanzhou City two, female, 71 years old, use voltage stabilizing adhesive plaster 15 days feedbacks, blood pressure was steady, and dizziness disappears.
Points for attention: need instruct through pharmacist when patient uses of the present invention.
Above, be only the embodiment utilizing this origination techniques content, the modification that any those skilled in the art use this creation to do, change, all belong to the scope of the claims that this creation is advocated, and be not limited to those disclosed embodiments.
Claims (4)
1. one kind substitutes the voltage stabilizing adhesive plaster of the external application Chinese medicine of taking medicine, it is characterized in that: this voltage stabilizing adhesive plaster is made up of mastic part and liquid part, voltage stabilizing adhesive plaster crude drug formula consists of: Semen Cassiae 6-12 gram, Radix Codonopsis 6-12 gram, Radix Astragali 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Ramulus Mori 6-12 gram, Fructus Aurantii 6-12 gram, Radix Linderae 6-12 gram, Radix Paeoniae Alba 6-15 gram, Radix Achyranthis Bidentatae 6-15 gram, Fructus Viticis 6-15 gram, Fructus Atriplicis Sibiricae 6-15 gram, Cortex Eucommiae 6-15 gram, Radix Angelicae Pubescentis 18-24 Ke, Gardenia 3-8 gram, Herba Asari 3-8 gram.
2. a kind of voltage stabilizing adhesive plaster substituting the external application Chinese medicine of taking medicine as claimed in claim 1, it is characterized in that, described liquid part preparation method be by the prescription of Chinese medicine take Semen Cassiae 6-12 gram, Radix Codonopsis 6-12 gram, Radix Astragali 6-12 gram, Radix Angelicae Sinensis 6-12 gram, Ramulus Mori 6-12 gram, Fructus Aurantii 6-12 gram, Radix Linderae 6-12 gram, Radix Paeoniae Alba 6-15 gram, Radix Achyranthis Bidentatae 6-15 gram, Fructus Viticis 6-15 gram, Fructus Atriplicis Sibiricae 6-15 gram, Cortex Eucommiae 6-15 gram, Radix Angelicae Pubescentis 18-24 Ke, Gardenia 3-8 gram, Herba Asari 3-8 gram, after co-grinding powder A; Powder A and solvent are loaded extractor, extracts to obtain suspension, filter, melt cinder is separated to obtain extracting solution I and residue I; Residue I and solvent are loaded extractor, extracts, the mixture after extraction filters, and obtains extract II; Extract I and extract II is mixed to get mixed liquor, and distilling under reduced pressure obtains the liquid part that product is voltage stabilizing adhesive plaster.
3. a kind of voltage stabilizing adhesive plaster substituting the external application Chinese medicine of taking medicine as claimed in claim 2, it is characterized in that, described solvent formula consists of: 95% ethanol 6g, glycerol 2g, propylene glycol 1g, water 1g.
4. a kind of voltage stabilizing adhesive plaster substituting the external application Chinese medicine of taking medicine as described in claim 1-3 any one, is characterized in that described voltage stabilizing adhesive plaster using method is for getting liquid part 2 in mastic part, pasting Yongquan acupoint.
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| CN103316156A (en) * | 2013-07-17 | 2013-09-25 | 罗柏林 | Externally-used medicine for preventing and treating hypertension, hyperlipidemia, hyperglycemia and hypotension and preparation method thereof |
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| CN103316156A (en) * | 2013-07-17 | 2013-09-25 | 罗柏林 | Externally-used medicine for preventing and treating hypertension, hyperlipidemia, hyperglycemia and hypotension and preparation method thereof |
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