CN105010364A - Bactericidal composition comprising probenazole and thifluzamide and application of bactericidal composition - Google Patents
Bactericidal composition comprising probenazole and thifluzamide and application of bactericidal composition Download PDFInfo
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- CN105010364A CN105010364A CN201510392790.7A CN201510392790A CN105010364A CN 105010364 A CN105010364 A CN 105010364A CN 201510392790 A CN201510392790 A CN 201510392790A CN 105010364 A CN105010364 A CN 105010364A
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- thifluzamide
- probenazole
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- WOSNCVAPUOFXEH-UHFFFAOYSA-N thifluzamide Chemical compound S1C(C)=NC(C(F)(F)F)=C1C(=O)NC1=C(Br)C=C(OC(F)(F)F)C=C1Br WOSNCVAPUOFXEH-UHFFFAOYSA-N 0.000 title claims abstract description 58
- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical compound C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 25
- 201000010099 disease Diseases 0.000 claims abstract description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 31
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 23
- 235000009566 rice Nutrition 0.000 claims abstract description 23
- 240000007594 Oryza sativa Species 0.000 claims abstract 2
- 230000003641 microbiacidal effect Effects 0.000 claims description 9
- 229940124561 microbicide Drugs 0.000 claims description 9
- 239000002855 microbicide agent Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 5
- 239000004562 water dispersible granule Substances 0.000 claims description 4
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- 238000009472 formulation Methods 0.000 claims description 2
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- 239000003814 drug Substances 0.000 description 19
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- 238000002360 preparation method Methods 0.000 description 11
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- 241000894006 Bacteria Species 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 239000003899 bactericide agent Substances 0.000 description 4
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
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- -1 phenyl amide compound Chemical class 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
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- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 3
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- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 2
- FRXSZNDVFUDTIR-UHFFFAOYSA-N 6-methoxy-1,2,3,4-tetrahydroquinoline Chemical compound N1CCCC2=CC(OC)=CC=C21 FRXSZNDVFUDTIR-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
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- 241001361634 Rhizoctonia Species 0.000 description 2
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229960000892 attapulgite Drugs 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
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- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 230000000855 fungicidal effect Effects 0.000 description 2
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- 230000002070 germicidal effect Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 230000010534 mechanism of action Effects 0.000 description 2
- 229910052625 palygorskite Inorganic materials 0.000 description 2
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- 239000010452 phosphate Substances 0.000 description 2
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
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- 229920001285 xanthan gum Polymers 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241001530056 Athelia rolfsii Species 0.000 description 1
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- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 description 1
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- 241000209140 Triticum Species 0.000 description 1
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- OYVABZRZDZPVQD-UHFFFAOYSA-N [F].C=1C=CSC=1 Chemical compound [F].C=1C=CSC=1 OYVABZRZDZPVQD-UHFFFAOYSA-N 0.000 description 1
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- 239000000645 desinfectant Substances 0.000 description 1
- SYHPANJAVIEQQL-UHFFFAOYSA-N dicarboxy carbonate Chemical compound OC(=O)OC(=O)OC(O)=O SYHPANJAVIEQQL-UHFFFAOYSA-N 0.000 description 1
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
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- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition comprising probenazole and thifluzamide. The active ingredients of the bactericidal composition are probenazole and thifluzamide in a weight ratio of 1: 20 to 20: 1, and the active ingredients in the composition account for 5-60% by mass. The bactericidal composition disclosed by the invention is high in bactericidal activity, delays generation and development of drug resistance of pathogens, reduces the preventing and treating dosage in the actual production, and is economical, efficient, safe and environmental-friendly. The bactericidal composition disclosed by the invention has a good preventing and treating effect on various crop diseases, and particularly has a remarkable preventing and treating effect on rice sheath blight disease.
Description
Technical field
The present invention relates to disinfectant use in agriculture field, be specifically related to bactericidal composition and the application thereof of a kind of probenazole-containing and thifluzamide.
Background technology
Rice sheath blight disease is by the popular disease in the microbial worldwide scope of miliary damping-off, one of most important disease on Ye Shi China paddy rice.Its distribution widely, has generation in each paddy rice main producing region of China, and especially in In Middle And Lower Reaches of Changjiang River and South China, harm is very serious, causes output sharply to decline.Selection and popularization disease-resistant variety is one of important measures of the water prevention rice sheath blight, in recent years, although Chinese scholars achieves a lot of progress in breeding for disease resistance, there is no at present and selects the completely immune rice varieties of rice sheath blight disease.Current Rhizoctonia solani Kuhn control still depends on chemical control.Current China adopts the medicament based on jinggangmeisu on the water prevention rice sheath blight always, namely reaches about 15% in rice tillering diseased plant rate in latter stage at the initial stage of a disease and starts to spray medicine control, and achieve certain effect.But existing report display, China's some areas rice sheath blight disease creates pesticide resistance to jinggangmeisu, and the control efficiency of this medicament caused constantly declines.If continue to control rice sheath blight disease, especially the surrogate-data technique of the water prevention rice sheath blight is filtered out, administer jinggangmeisu pesticide resistance simultaneously and promote the sustainable control of rice sheath blight disease, having become the significant challenge that numerous scientific workers and Rice Cropping person face.
Probenazole belongs to benzimidazole germicide; a kind of efficient, wide spectrum, systemic fungicide; the plurality of plant diseases such as penicilliosis, anthracnose, gray mold, scab, powdery mildew of orange storing disease, banana disease, wheat scab, bakanae disease of rice, apple core pears can be prevented and treated; protective effect and therapeutic action are had concurrently to control of plant disease; various crop disease can be prevented and treated, with jinggangmeisu without mutual pesticide resistance.
The chemical name of probenazole: 2-(4-thiazolyl)-1H-benzimidazole.
The chemical structural formula of probenazole is shown below:
Thifluzamide is again thiophene fluorine bacterium amine, it is the phenyl amide compound containing thiazole ring, belongs to succinate dehydrogenase inhibitors, has strong Uptake and translocation and long lasting effect, can prevent and treat various crop disease, particularly the fungus-caused disease of basidiomycetes Rhizoctonia has good control efficiency.Its Main Function mechanism suppresses succinate dehydrogenase in germ tricarbonic acid cycle, causes thalline dead.Thifluzamide all has activity to pathomycetes such as Rhizoctonia, Puccinia, Ustilago, Tilletia, corticium, nuclear cavity Pseudomonas, especially special efficacy is had, with jinggangmeisu without mutual pesticide resistance to the fungus-caused disease of Basidiomycetes such as banded sclerotial blight, damping off etc.
The chemical name of thifluzamide: the bromo-2-methyl of 2', 6'-bis--4'-trifluoromethoxy-4-Trifluoromethyl-1,3-thiadiazoles-5-hydroxyl anilide
The chemical structural formula of thifluzamide is shown below:
Probenazole and thifluzamide bacterium are lower toxicity or micro-virus kind agricultural chemicals, belong to efficient, low toxicity, environmentally friendly type bactericide.Probenazole mainly acts on the cell division of fungi, the succinate dehydrogenase of thifluzamide effect and thalline, thus the object reaching sterilization, there is not mutual pesticide resistance in the two.But a lot of research shows, if these two kinds of medicaments are used alone controlling disease, can pathogen are made in the short period of time to develop immunity to drugs, cause preventive effect to reduce, even prevent and treat failure.Fungicide resistance Action Committee (FRAC) advises, is used by the composite reagent of different mechanism of action, can avoid or delay drug-fast generation.Therefore, the two is combined as bactericidal composition, what effectively can not only solve rice sheath blight disease prevents and treats problem, and can avoid or delay pathogen and develop immunity to drugs to it.
Summary of the invention
The invention provides the bactericidal composition of a kind of probenazole-containing and thifluzamide, there is bactericidal activity high, delay pathogen pesticide resistance emergence and development, and dosage total in unit are is declined, economic, efficient, environmental protection.
Technical scheme of the present invention is:
The microbicide compositions of a kind of probenazole-containing and thifluzamide, it is characterized in that, the active component of described microbicide compositions is probenazole and thifluzamide, and the mass ratio of thifluzamide and probenazole is 1:20 to 20:1, and in composition, active component mass percentage is 5-60%.
Described active component thifluzamide and the mass ratio of probenazole are 1:10 to 10:1.
Described thifluzamide and the mass ratio of probenazole are 1:3-8.
Described thifluzamide and the mass ratio of probenazole are 1:4-6.
The formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
This microbicide compositions has higher control efficiency to various crop disease, particularly remarkable to rice sheath blight disease controlling effect, for the control of rice sheath blight disease and false smut.
Remarkable result of the present invention and advantage are:
Two classes are had the bactericide of different mechanism of action by the present invention, namely benzimidazole germicide probenazole and SDHI series bactericidal agent thifluzamide combined, and be processed into the upper easy-to-use preparation of production, biologically active is high, dosage total in unit are declines, greatly reduce dispenser cost, delaying pathogen pesticide resistance emergence and development to a greater extent simultaneously, reduce disease fungus produces resistance risk to single bactericide, extend the service life of each component in bactericidal composition, thus reach effect that is economic, efficient, environmental protection.
The present invention has higher control efficiency to crop fungal disease, there is notable synergistic effect between two components; Part high price pesticide species can be replaced, and reduce dosage, effectively reduce ecological disruption and environmental pollution, and crop yield and quality can be improved; In the present invention, probenazole and thifluzamide all belong to the toxicity such as low, and to people and animals, beneficial organism, Environmental security; The pesticide resistance of germ to single medicament can be delayed.
First the EC of probenazole and thifluzamide two single compound (hereinafter referred to as medicament) is measured
50(drug safety index), according to the EC of two single medicaments
50set the portfolio ratio of two medicaments by Wadley method, and according to Wadley coefficient of synergism C value, determine suitable composition ratio, then verified by the abundant method of Sun Yun.
Test objective thing is Rhizoctonia solani Kuhn, but does not limit so.Test adopts mycelial growth determination method, makes pastille medium by different disposal, and each process 4 repetitions, connect bacterium after 3 days, investigate the growth inhibitory effect of each process to Rhizoctonia solani Kuhn.By the linear regression analysis between the probit value of preventive effect and the logarithm value of serial drug concentration, obtain the EC of each medicament
50, calculate coefficient of synergism (SR) according to Wadley method, and make overall merit accordingly.SR≤0.5 represents to have antagonism, and 0.5 < SR < 1.5 represents to have summation action, and SR >=1.5 are synergistic effect.SR value calculating method is as follows:
EC
50(theoretical value)=(a+b)/(a/EC
50A+ b/EC
50B)
SR=EC
50(theoretical value)/EC
50(real value)
SR≤0.5, then two kinds of medicament mixtures have antagonistic action
SR=0.5 ~ 1.5, then two kinds of medicament mixtures have addition
SR >=1.5, then two kinds of medicament mixtures have synergistic effect
Table 1 thifluzamide and probenazole composition are to the Wadley method measurement result of Rhizoctonia solani Kuhn
| Proportioning (S:SF) | Regression equation | Correlation coefficient | EC 50 | SR |
| Probenazole (S) | Y=2.617X+6.010 | 0.9941 | 0.411 | |
| Thifluzamide (SF) | Y=1.397X+6.081 | 0.9948 | 0.168 | |
| 20:1 | Y=0.782X+5.479 | 0.9882 | 0.2442 | 1.5746 |
| 10:1 | Y=1.104X+5.725 | 0.9776 | 0.2203 | 1.6488 |
| 5:1 | Y=1.142X+5.915 | 0.9888 | 0.1579 | 2.0973 |
| 1:1 | Y=0.989X+5.800 | 0.9863 | 0.1551 | 1.5377 |
| 1:5 | y=0.401x+5.3657 | 0.9308 | 0.1225 | 1.5213 |
| 1:10 | Y=1.359X+6.284 | 0.9794 | 0.1127 | 1.5753 |
| 1:20 | Y=0.753X+5.630 | 0.9923 | 0.1458 | 1.1856 |
Note: S is probenazole, and SF is thifluzamide.
Can analyze from above data, probenazole and the fungistatic effect of thifluzamide composition to Rhizoctonia solani Kuhn of different proportion are different, on the whole, its ratio has synergy or addition in the scope of 1:20 to 20:1, and wherein maximum enhancing proportions is 5:1.
Below in conjunction with embodiment, the invention will be further described, but be not limited thereto.
Embodiment
Embodiment 1 (preparation method of 60% thifluzamide probenazole wetting powder)
Composition of raw materials: by mass percentage
Active component thifluzamide 10%
Active component probenazole 50%
NNO 6%
Amine carbonate 3%
White carbon 10%
Kaolin surplus.
Preparation method: by above-mentioned substance Homogeneous phase mixing, mixture is pulverized through airslide disintegrating mill, obtained wetting powder.
Embodiment 2 (preparation method of 30% thifluzamide probenazole suspending agent)
Active component thifluzamide 15%
Active component probenazole 15%
Sodium lignin sulfonate 6%
BY140 4%
Xanthans 0.1%
Propane diols 1%
Phosphate defoamer 0.1%
Water surplus.
Preparation method: according to formula, weighs in proportion by individual component, adds ball mill ball milling 30 minutes, filter, suction dispersion tank high speed shear was fully ground through sand mill after 3 minutes, controlled solid constituent particle diameter within 2 microns, stir after grinding terminates, obtain suspending agent product.Embodiment 3 (preparation method of 40% thifluzamide probenazole water dispersible granules)
Active component thifluzamide 5%
Active component probenazole 35%
Methyl fatty acid amides benzene sulfonic acid sodium salt 5%
Sodium carbonate 3%
Sodium lignin sulfonate 6%
Attapulgite surplus.
Preparation method: thifluzamide, probenazole, Methyl fatty acid amides benzene sulfonic acid sodium salt, sodium carbonate, attapulgite are mixed together evenly, particle diameter 5 μm is crushed to through airslide disintegrating mill, obtain female powder, female powder is fully mixed rear granulation with sodium lignin sulfonate, dries, sieves, thus obtained water-dispersible granules.
Embodiment 4 (20% thifluzamide probenazole suspending agent)
Active component thifluzamide 15%
Active component probenazole 5%
Sodium lignin sulfonate 6%
BY140 4%
Xanthans 0.1%
Propane diols 1%
Phosphate defoamer 0.1%
Water surplus.
Preparation method: with embodiment 2.
Embodiment 5 (45% thifluzamide probenazole missible oil)
Composition of raw materials: by mass percentage
Active component thifluzamide 35%
Active component probenazole 10%
Anhydrous calcium salt 5%
NP-10 5%
Dimethylbenzene surplus.
Preparation method: fully dissolved in dimethylbenzene reactor by active component thifluzamide, makes A liquid; Active component probenazole is fully dissolved in dimethylbenzene reactor, makes B liquid; Not stopping, under stirring, A liquid is mixed into B liquid, stirring, adding anhydrous calcium salt and NP-10, then adjusting content with solvent xylene.
Embodiment 6 (preparation method of 48% thifluzamide probenazole missible oil)
Composition of raw materials: by mass percentage
Active component thifluzamide 36%
Active component probenazole 12%
DMF 30%
Anhydrous calcium salt 5%
NP-10 5%
Dimethylbenzene surplus.
Preparation method: with embodiment 5.
control efficiency is tested:
The field efficiency test of rice sheath blight disease carries out in Fengyang County, and test area is 0.3hm
2, often process in triplicate, in the control of Rise's boot period spray medicine, carry out preventive effect investigation in dispenser after 15 days, control the results are shown in Table 2.Result shows, bactericidal composition containing probenazole and thifluzamide has good control efficiency to rice sheath blight disease, can reach higher control efficiency under same dose or lower using dosage, and each process preventive effect bacterium of this bactericidal composition is greater than 85%, is significantly higher than contrast medicament.
The land for growing field crops drug effect * of the table 2 thifluzamide probenazole bactericidal composition water prevention rice sheath blight
Owing to being also the proper control time preventing and treating false smut at Rise's boot period, we have investigated the control efficiency to false smut after chemical control simultaneously, and control the results are shown in Table 3.Result shows, the bactericidal composition containing probenazole and thifluzamide has good control efficiency to false smut, and the preventive effect under each treatment dosage, all higher than 85%, is significantly higher than the preventive effect of contrast medicament.
Table 3 thifluzamide probenazole bactericidal composition is to the field efficacy of false smut
From the data of table 2 and table 3, the bactericidal composition containing thifluzamide and probenazole all has good preventive effect to rice sheath blight disease and false smut, and the preventive effect of different ratio is different.It should be noted that when the proportioning of probenazole and thifluzamide is 5:1, compared with other processes, under lower consumption, but to two kinds of diseases, there is higher preventive effect, show good synergistic function; And indoor biometrics result also shows, when the proportioning of probenazole and thifluzamide is 5:1, the coefficient of synergism measured is the highest, and the result of the two is consistent.
Finally, it is also to be noted that what enumerate above is only several specific embodiments of the present invention.Obviously, the invention is not restricted to above embodiment, a lot of distortion can also be had.All distortion that those of ordinary skill in the art can directly derive from content disclosed by the invention or associate, all think the scope of protection of the invention.
Claims (6)
1. the microbicide compositions of a probenazole-containing and thifluzamide, it is characterized in that, the active component of described microbicide compositions is probenazole and thifluzamide, and the mass ratio of thifluzamide and probenazole is 1:20 to 20:1, and in composition, active component mass percentage is 5-60%.
2. the bactericidal composition of probenazole-containing according to claim 1 and thifluzamide, is characterized in that: described active component thifluzamide and the mass ratio of probenazole are 1:10 to 10:1.
3. the bactericidal composition of probenazole-containing according to claim 1 and thifluzamide, is characterized in that: described thifluzamide and the mass ratio of probenazole are 1:3-8.
4. the bactericidal composition of probenazole-containing according to claim 1 and thifluzamide, is characterized in that: described thifluzamide and the mass ratio of probenazole are 1:4-6.
5. the microbicide compositions of probenazole-containing according to claim 1 and 2 and thifluzamide, is characterized in that: the formulation of described microbicide compositions is suspending agent, missible oil, water dispersible granules or wetting powder.
6. the application of the probenazole-containing according to any one of claim 1-2 and the microbicide compositions of thifluzamide, is characterized in that: for the control of rice sheath blight disease and false smut.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510392790.7A CN105010364B (en) | 2015-07-07 | 2015-07-07 | The bactericidal composition and its application of a kind of probenazole-containing and thifluzamide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510392790.7A CN105010364B (en) | 2015-07-07 | 2015-07-07 | The bactericidal composition and its application of a kind of probenazole-containing and thifluzamide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105010364A true CN105010364A (en) | 2015-11-04 |
| CN105010364B CN105010364B (en) | 2017-06-27 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106857590A (en) * | 2017-02-26 | 2017-06-20 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition of probenazole-containing and benzene metsulfovax |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006024333A2 (en) * | 2004-08-17 | 2006-03-09 | Syngenta Participations Ag | Aqueous neonicotinoid compositions for seed treatment |
| CN101755825A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing thifluzamide |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006024333A2 (en) * | 2004-08-17 | 2006-03-09 | Syngenta Participations Ag | Aqueous neonicotinoid compositions for seed treatment |
| CN101755825A (en) * | 2009-11-23 | 2010-06-30 | 陈章艳 | Bactericide composition containing thifluzamide |
Non-Patent Citations (1)
| Title |
|---|
| 陈杨林等: "噻菌灵防治小麦赤霉、雪霉及条锈病田间试验", 《植物保护》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106857590A (en) * | 2017-02-26 | 2017-06-20 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of bactericidal composition of probenazole-containing and benzene metsulfovax |
| CN106857590B (en) * | 2017-02-26 | 2021-11-30 | 安徽省农业科学院植物保护与农产品质量安全研究所 | Bactericidal composition containing thiabendazole and benthiavalicarb isopropyl |
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