CN104998021A - Oral medicine used for treating thromboangiitis obliterans, and preparation method thereof - Google Patents

Abstract

The invention discloses an oral medicine used for treating thromboangiitis obliterans, and a preparation method thereof. The oral medicine is prepared from, by mass, 1 to 3 parts of dandelion, 1 to 3 parts of herba violae, 1 to 3 parts of lonicera japonica, 1 to 3 parts of gynura bicolor, 1 to 3 parts of paris rhizome, 1 to 3 parts of radix angelicae lateralis preparata, 1 to 3 parts of radix paeoniae rubra, 1 to 3 parts of salvia aerea Levl., 1 to 3 parts of caulis spatholobi, 1 to 3 parts of radix cyathulae, 1 to 3 parts of astragalus membranaceus, and 1 to 3 parts of radix stephaniae tetrandrae. A preparation method comprises following steps: high quality one-grade dandelion, herba violae, lonicera japonica, gynura bicolor, paris rhizome, radix angelicae lateralis preparata, radix paeoniae rubra, salvia aerea Levl., caulis spatholobi, radix cyathulae, astragalus membranaceus, and radix stephaniae tetrandrae are weighed according to the mass ratio, are subjected to impurity removing and dust removing, are packaged with a cloth bag, and the cloth bag is sealed; the sealed bag is immersed in cold boiled water for about half an hour, the immersed raw materials and a clarified liquer obtained via immersion are delivered into a drug-decocting machine, cooled boiled water is added until water level is 33mm higher than the sealed bag, and an obtained mixture is subjected to first decoction for 35min; a medicine liquid is obtained via filtration, slightly warm boiled water is added until water level is 30mm higher than the sealed bag, and an obtained mixed material is subjected to second decoction for 30min; obtained solution is mixed, and is subjected to concentration so as to obtain 1710ml of a 50% traditional Chinese medicine liquid; and the traditional Chinese medicine liquid is packaged with bags, and is stored in a refrigerator.

Description

A kind of endo-medicine and preparation method for the treatment of thromboangiitis obliterans

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of endo-medicine for the treatment of thromboangiitis obliterans, particularly for the endo-medicine of mankind's Patients With Thromboangitis Obliterans and the field of preparation method.

Background technology

Chinese medicine is thought: thromboangiitis obliterans is in a kind of rare chronic recurrent, the segmental diseases associated with inflammation of small artery and vein, and lower limb are common.Show as suffering limb ischemia, pain, intermittent claudication, pulsation of foot dorsal artery weaken or disappear and migrans Superficial phlebitis, severe patient has acra ulcer and necrosis.Its clinical manifestation is: primary disease is more common in person between twenty and fifty, is apt to occur in lower limb.Suffering limb presents momentary or persistence is pale, cyanosis, have scorching hot and twinge, and when sick limb is sagging, color of the leather reddens, and bleaches during upper act, and then toes are numb, and Calf muscle pain, excites during walking, disappears during rest; Often there is superficial phlebitis and edema in calf.Find during inspection that pulsation of foot dorsal artery weakens or disappears.Along with PD can there is intermittent claudication and Raynaud phenomenon, night, the pain increased, toes sharp ache, skin cyanosis, and then toe-end ulcer or gangrene and turn black, spread to proximal part gradually.

So, just how finding a kind of endo-medicine for the treatment of thromboangiitis obliterans, is our current problem in urgent need to solve.

Summary of the invention

The object of this invention is to provide a kind of endo-medicine and preparation method for the treatment of thromboangiitis obliterans, to solve Patients With Thromboangitis Obliterans restorative problem early.This medicine is that have advantages of perfect compatibility, the efficacy of a drug is powerful, hit pathogenesis, fully demonstrated heat-clearing and toxic substances removing, helped with blood circulation promoting and blood stasis dispelling with common Chinese herbal medicine for raw material, qi and blood tonifying, helps Therapeutic Principle with blood circulation promoting and blood stasis dispelling.

For reaching the object of foregoing invention, the technical solution adopted in the present invention is: provide a kind of endo-medicine for the treatment of thromboangiitis obliterans, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Herba Taraxaci 1-3 part;

Herba Violae 1-3 part;

Flos Lonicerae 1-3 part;

Radix Semiaquilegiae 1-3 part;

Rhizoma Paridis 1-3 part;

Radix Angelicae Sinensis 1-3 part;

Radix Paeoniae Rubra 1-3 part;

RADIX SALVIAE MILTIORRHIZAE 1-3 part;

Caulis Spatholobi 1-3 part;

Radix Cyathulae 1-3 part;

Radix Astragali 1-3 part;

Radix Stephaniae Tetrandrae 1-3 part.

According to the endo-medicine for the treatment of thromboangiitis obliterans provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Herba Taraxaci 1 part;

Herba Violae 1 part;

Flos Lonicerae 1 part;

Radix Semiaquilegiae 1 part;

Rhizoma Paridis 1 part;

Radix Angelicae Sinensis 1 part;

Radix Paeoniae Rubra 1 part;

RADIX SALVIAE MILTIORRHIZAE 1 part;

Caulis Spatholobi 1 part;

Radix Cyathulae 1 part;

The Radix Astragali 1 part;

Radix Stephaniae Tetrandrae 1 part.

Treat endo-medicine and the preparation method of thromboangiitis obliterans, it is characterized in that, described method comprises the steps:

A, the one-level Herba Taraxaci 1 part selecting high-quality clean, Herba Violae 1 part, Flos Lonicerae 1 part, Radix Semiaquilegiae 1 part, Rhizoma Paridis 1 part, Radix Angelicae Sinensis 1 part, Radix Paeoniae Rubra 1 part, RADIX SALVIAE MILTIORRHIZAE 1 part, Caulis Spatholobi 1 part, Radix Cyathulae 1 part, the Radix Astragali 1 part, Radix Stephaniae Tetrandrae 1 part, after picking decontamination and dust respectively, enter tying in cloth bag stand-by;

B, the above-mentioned cloth bag tying mouth put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water adding medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, the tepor boiled water again adding medicine 30mm carries out second time and decocts 30 minutes, and mixing is condensed into the herb liquid 1710 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed.

Treat endo-medicine and the preparation method of thromboangiitis obliterans, it is characterized in that, described instructions of taking is: divided by the herb liquid prepared and take for three days, the morning, noon and afternoon service once, dosage 190 milliliters/time, taking medicine before meal.Take medicine 40-45 agent, all diseases are all removed, and disease obtains recovery from illness.

The medicine for the treatment of thromboangiitis obliterans provided by the present invention is oral traditional Chinese medicine composition, and it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

Herba Taraxaci, nature and flavor: cold in nature, bitter in the mouth, sweet, have effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, are used for the treatment of acute mastitis, scrofula, furuncle swelling toxin, pharyngalgia, lung abscess, acute appendicitis, conjunctival congestion, jaundice due to damp-heat, the puckery pain of pyretic stranguria;

Herba Violae, nature and flavor: bitter, cold, have clearing away heat-damp and promoting diuresis, effect of removing toxic substances and promoting subsidence of swelling, are used for the treatment of furuncle, carbuncle, scrofula, jaundice, dysentery, diarrhoea, conjunctival congestion, sore throat, venom;

Flos Lonicerae, nature and flavor: sweet in the mouth, cold in nature, have heat-clearing and toxic substances removing, dispelling wind and heat pathogens, dredge effect of throat, relieving restlessness of relieving summer heat, be used for the treatment of the diseases such as febrile disease due to summer-heat pathogen, dysentery, influenza, furuncle toxic swelling, acute and chronic tonsillitis, periodontitis;

Radix Semiaquilegiae, nature and flavor: Gan Danliang, effect of tool heat-clearing and toxic substances removing, nourishing the lung to arrest cough, dissipating blood stasis for subsidence of swelling, promoting the production of body fluid to quench thirst, is used for the treatment of the diseases such as exogenous high fever, heatstroke fever, cough due to lung-heat, cold hoarseness, carbuncle sore tumefacting virus, treating swelling and pain by traumatic injury;

Rhizoma Paridis, nature and flavor: toil, cold, poisonous, there is effect of heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cool liver arresting convulsion, be used for the treatment of carbuncle sore tumefacting virus, pharyngeal swelling sore throat, acute mastitis, snake bite and insect sting, traumatic pain, liver-heat tic, control carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, infantile convulsion tic, snake bite and insect sting;

Radix Angelicae Sinensis, nature and flavor: sweet in the mouth, pungent, micro-hardship, having enriches blood invigorates blood circulation, menstruction regulating and pain relieving, and effect of loosening bowel to relieve constipation is used for the treatment of blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores;

Radix Paeoniae Rubra, nature and flavor: bitter, be slightly cold, have effect of clearing away heat and cooling blood, eliminating stasis to stop pain, are used for the treatment of maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection;

RADIX SALVIAE MILTIORRHIZAE, nature and flavor: lightly seasoned, micro-hardship, cool in nature, there is effect of invigorating the kidney and strengthening the bones, promoting blood flow to regulate menstruation, cooling blood for hemostasis, be used for the treatment of lumbago due to renal deficiency, rheumatalgia, dizziness, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia, have blood in stool, spit blood, epistaxis, traumatic injury stasis of blood pain, knife injury is hemorrhage;

Caulis Spatholobi, nature and flavor: bitter in the mouth, micro-sweet, warm in nature, have effect of relaxing muscles and tendons to promote blood circulation, nourishing blood for regulating menstruation, be used for the treatment of numb hand and foot, quadriplegia, rheumatic arthralgia, women have through uncomfortable, dysmenorrhea, amenorrhea;

Radix Cyathulae, nature and flavor: sweet in the mouth, micro-hardship, property are flat, there is effect of promoting blood circulation to restore menstrual flow, expelling wind and removing dampness, easing joint movement, inducing diuresis for treating stranguria syndrome, be used for the treatment of blood stasis amenorrhea, dysmenorrhea, difficult labour, retention of placenta, arthralgia, flaccidity of the lower limbs clonic spasm of the muscle, hematuria, stranguria with blood, injury from falling down;

The Radix Astragali, nature and flavor: sweet in the mouth, feeble QI temperature, there is effect of invigorating QI to consolidate the body surface resistance, diuresis detoxification, evacuation of pus, expelling pus and promoting granulation, be used for the treatment of that the deficiency of vital energy is weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty are burst, burst for a long time do not hold back, blood deficiency dull yellowish colored skin, interior-heat are quenched one's thirst, chronic nephritis proteinuria, diabetes etc.;

Radix Stephaniae Tetrandrae, nature and flavor: bitter, acrid, cold, have effect of wind-damp dispelling, pain relieving, diuretic, are used for the treatment of the diseases such as Fengshi Guanjie pain, damp and hot limbs pain, edema, dysuria, beriberi damp-edema.

When taking, divided by the herb liquid prepared and take for three days, the morning, noon and afternoon service once, dosage 190 milliliters/time, taking medicine before meal.Take medicine 40-45 agent, all diseases are all removed, and disease obtains recovery from illness.This medicine is that have advantages of perfect compatibility, the efficacy of a drug is powerful, hit pathogenesis, fully demonstrated heat-clearing and toxic substances removing, helped with blood circulation promoting and blood stasis dispelling with common Chinese herbal medicine for raw material, qi and blood tonifying, helps Therapeutic Principle with blood circulation promoting and blood stasis dispelling.

Detailed description of the invention

Thromboangiitis obliterans is in a kind of rare chronic recurrent, the segmental diseases associated with inflammation of small artery and vein, and lower limb are common.Show as suffering limb ischemia, pain, intermittent claudication, pulsation of foot dorsal artery weaken or disappear and migrans Superficial phlebitis, severe patient has acra ulcer and necrosis.Its clinical manifestation is: primary disease is more common in person between twenty and fifty, is apt to occur in lower limb.Suffering limb presents momentary or persistence is pale, cyanosis, have scorching hot and twinge, and when sick limb is sagging, color of the leather reddens, and bleaches during upper act, and then toes are numb, and Calf muscle pain, excites during walking, disappears during rest; Often there is superficial phlebitis and edema in calf.Find during inspection that pulsation of foot dorsal artery weakens or disappears.Along with PD can there is intermittent claudication and Raynaud phenomenon, night, the pain increased, toes sharp ache, skin cyanosis, and then toe-end ulcer or gangrene and turn black, spread to proximal part gradually.

The present invention is exactly treatment for above-mentioned thromboangiitis obliterans and a kind of Chinese herbal medicine formula proposed, and the medicine effect adopting this formula to prepare is good, instant effect, and toxic and side effects is little, can effectively treat above-mentioned thromboangiitis obliterans.Below specific embodiment provided by the present invention is described in detail.

Embodiment 1:

The one-level Herba Taraxaci 30 grams selecting high-quality clean, Herba Violae 30 grams, Flos Lonicerae 30 grams, Radix Semiaquilegiae 30 grams, Rhizoma Paridis 30 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Rubra 12 grams, RADIX SALVIAE MILTIORRHIZAE 20 grams, Caulis Spatholobi 20 grams, Radix Cyathulae 20 grams, the Radix Astragali 15 grams, Radix Stephaniae Tetrandrae 15 grams, after picking decontamination and dust respectively, enter tying in cloth bag stand-by; The above-mentioned cloth bag tying mouth is put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water adding medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, the tepor boiled water again adding medicine 30mm carries out second time and decocts 30 minutes, and mixing is condensed into the herb liquid 1710 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed.When taking, divided by the herb liquid prepared and take for three days, the morning, noon and afternoon service once, dosage 190 milliliters/time, taking medicine before meal.Take medicine 40-45 agent, all diseases are all removed, and disease obtains recovery from illness.

Embodiment 2:

The one-level Herba Taraxaci 33 grams selecting high-quality clean, Herba Violae 33 grams, Flos Lonicerae 33 grams, Radix Semiaquilegiae 33 grams, Rhizoma Paridis 30 grams, Radix Angelicae Sinensis 11 grams, Radix Paeoniae Rubra 13 grams, RADIX SALVIAE MILTIORRHIZAE 22 grams, Caulis Spatholobi 22 grams, Radix Cyathulae 22 grams, the Radix Astragali 16 grams, Radix Stephaniae Tetrandrae 16 grams, after picking decontamination and dust respectively, enter tying in cloth bag stand-by; The above-mentioned cloth bag tying mouth is put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water adding medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, the tepor boiled water again adding medicine 30mm carries out second time and decocts 30 minutes, and mixing is condensed into the herb liquid 1710 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed.When taking, divided by the herb liquid prepared and take for three days, the morning, noon and afternoon service once, dosage 190 milliliters/time, taking medicine before meal.Take medicine 40 doses, all diseases are all removed, and disease obtains recovery from illness.

Embodiment 3:

The one-level Herba Taraxaci 30 grams selecting high-quality clean, Herba Violae 30 grams, Flos Lonicerae 30 grams, Radix Semiaquilegiae 30 grams, Rhizoma Paridis 30 grams, Radix Angelicae Sinensis 10 grams, Radix Paeoniae Rubra 12 grams, RADIX SALVIAE MILTIORRHIZAE 20 grams, Caulis Spatholobi 20 grams, Radix Cyathulae 20 grams, the Radix Astragali 15 grams, Radix Stephaniae Tetrandrae 15 grams, after picking decontamination and dust respectively, enter tying in cloth bag stand-by; The above-mentioned cloth bag tying mouth is put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water adding medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, the tepor boiled water again adding medicine 30mm carries out second time and decocts 30 minutes, and mixing is condensed into the herb liquid 1710 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed.When taking, divided by the herb liquid prepared and take for three days, the morning, noon and afternoon service once, dosage 190 milliliters/time, taking medicine before meal.Take medicine 40-42 agent, all diseases are all removed, and disease obtains recovery from illness.

The present invention is through the treatment to nearly one hundred routine patient, and therapeutic effect is remarkable, and toxic and side effects is little, and part allusion quotation shape case is as follows.

Patient: leaf XX, man, 30 years old, address: Chengdu, Sichuan Province

Illness symptom: patient is from the spring 1998 Winter Solstice in 1997, and self-induction right lower extremity is numb, feels cold, and when walking, shank acid is swollen, easily tired.Summer in 1998, right little toes traumatic hemorrhage, did not heal through controlling because of logrolling.Between July all toes of right foot blue, feel cold, pale, and occur intermittent claudication, and often there is swelling when activity in shank gastrocnemius, through multi-treatment, but symptom development.To in mid-September, 1999, right foot 5 toe heads successively fester, and are connected at the bottom of front foot in the toe sole of the foot joint of 3,4,5 interdigits, visible 5 × llcm ulceration, and 3,5 dactylolysis, ulcer is prolonged not to heal, and pain lasts is violent, night more so, can not fall asleep, embrace foot call and spend the night, walk with difficulty in the daytime, Dong Zesuan distending pain Chu, twitches.Checking right lower extremity amyotrophy, is very with muscles of leg especially, swelling below ankle joint, skin is red scorching hot, the large small stream arteries and veins of suffering limb (internal malleolus rear), (dorsal artery of foot), popliteal arteriopalmus all disappearance ， popliteal nest arteriotony fails to measure, and femoral pulse weakens to fall YANG pulse.Right foot 5 toe head ulcer, gangrene are alternate, and rot purple black, pus is dripping, breath malodor, and occur together heat, confusion, and poor appetite is become thin.Deep red tongue, while there is ecchymosis, dry, rough and yellow fur, stringy,thready and rapid pulse.Be diagnosed as third phase thromboangiitis obliterans, secondary necrosis companion secondary infection.

Treatment (first stage): think the strongly fragrant heat-transformation of a specified duration of its cold-damp and become poison, meridians block, stagnation of QI-blood, then meat is rotten, and muscle is rotten, and bone is withered, and bone takes off.Therefore from JIUYUE in 1999 18 days, intending first using heat-clearing and toxic substances removing, helping with blood circulation promoting and blood stasis dispelling as controlling.Square top " herb liquid ".Decoction every day potion.And above right ankle joint tourniquet in about 5cm place, with punching connect, each 10 milliliters of mixing of Radix Ilicis Pubescentis injection, row vein contrastream injection, unclamps tourniquet after 20 minutes, every day 1-2 time, continuous 22 days.Local and in right amount each with Folium Artemisiae Argyi, Folium Pini, eucalyptus leaves, Caulis Lonicerae leaf, Ramulus Mori, decocting water, first smokes and wash afterwards, drying rear with being soaked with 0.2% bromo geramine gauze soak.More than month, all diseases are clearly better, and pain disappears, and food of receiving is as usual, sleeps good.In the minor operation debridement of row toes sequestrum on October 30.

It is light red that (second stage) looks its skin ulcer face granulation new life, has a small amount of yellow fluid to ooze out, shallow complexion, become thin weak, and the atrophy of suffering limb Calf muscle is not multiple, and body of the tongue is yellowish.Tongue book is white, and deep,thready and forceless pulse, has levying of prolonged illness deficiency of both QI and blood.From November 15, plan qi and blood tonifying, helped with blood circulation promoting and blood stasis dispelling for controlling, and side uses " supplementing qi and invigorating vasculum soup ".Potion decoction every day.And with compound Salviae Miltiorrhizae, each 6 milliliters of mixing of Radix Ilicis Pubescentis injection, row vein contrastream injection, method as above, day row once, continuous 18 days.Disappear to December in 1999 all diseases on the 8th, wound surface all heals, and all diseases are all removed, and disease obtains recovery from illness.Follow up a case by regular visits to 3 year, have no recurrence.

Claims (3)

1. treat an endo-medicine for thromboangiitis obliterans, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Herba Taraxaci 1-3 part;

Herba Violae 1-3 part;

Flos Lonicerae 1-3 part;

Radix Semiaquilegiae 1-3 part;

Rhizoma Paridis 1-3 part;

Radix Angelicae Sinensis 1-3 part;

Radix Paeoniae Rubra 1-3 part;

RADIX SALVIAE MILTIORRHIZAE 1-3 part;

Caulis Spatholobi 1-3 part;

Radix Cyathulae 1-3 part;

Radix Astragali 1-3 part;

Radix Stephaniae Tetrandrae 1-3 part.

2. the endo-medicine for the treatment of thromboangiitis obliterans according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:

Herba Taraxaci 1 part;

Herba Violae 1 part;

Flos Lonicerae 1 part;

Radix Semiaquilegiae 1 part;

Rhizoma Paridis 1 part;

Radix Angelicae Sinensis 1 part;

Radix Paeoniae Rubra 1 part;

RADIX SALVIAE MILTIORRHIZAE 1 part;

Caulis Spatholobi 1 part;

Radix Cyathulae 1 part;

The Radix Astragali 1 part;

Radix Stephaniae Tetrandrae 1 part.

3. the endo-medicine of the treatment thromboangiitis obliterans described in claim 1 or 2 and a preparation method, is characterized in that, described method comprises the steps:

A, according to mass parts than choosing the clean one-level Herba Taraxaci of high-quality, Herba Violae, Flos Lonicerae, Radix Semiaquilegiae, Rhizoma Paridis, Radix Angelicae Sinensis, Radix Paeoniae Rubra, RADIX SALVIAE MILTIORRHIZAE, Caulis Spatholobi, Radix Cyathulae, the Radix Astragali, Radix Stephaniae Tetrandrae, after picking decontamination and dust respectively, enter tying in cloth bag stand-by;

B, the above-mentioned cloth bag tying mouth put into about cold boiled water soaks half an hour, with osmotic drug degree of being organized as, then again the clear liquor of soaked medicine and soak medicine is put into boiling machine in the lump, the cold boiled water adding medicine 33mm carries out first time decoction 35 minutes, after leaching medicinal liquid, the tepor boiled water again adding medicine 30mm carries out second time and decocts 30 minutes, and mixing is condensed into the herb liquid 1710 milliliters of 50%, enters fridge freshness retaining for subsequent use after packed.