CN104971412B - Vibration medicine storage unit of powder inhalation dosing device - Google Patents
Vibration medicine storage unit of powder inhalation dosing device Download PDFInfo
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Abstract
A vibration medicine storage unit of a powder inhalation medicine feeding device belongs to the field of suction type medicine feeding instruments. The rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow channel form a vibration medicine storage unit of the powder inhalation administration device; when the powder storage container of the powder storage unit is subjected to impact vibration, the second vibration part, namely the inner medicine barrel, which can vibrate synchronously and freely is further arranged in the powder storage container, so that the medicine powder in the powder storage container is subjected to compound vibration, the metering accuracy of the amount of the medicine powder supplied by the powder storage unit in each administration process of the whole powder inhalation administration device is better ensured, the workload of mechanical structure design change required by the change of the filled medicine powder variety can be reduced, and the good adaptability of the powder inhalation administration device to a wider range of powder medicament varieties is increased. Can be widely applied to the design and manufacture fields of powder aerosol administration devices with various specifications.
Description
Technical Field
The invention belongs to the field of devices for inputting media into human bodies, and particularly relates to an inhalation type drug delivery device for delivering a powder inhalation with a specified dose into the lungs of a patient through an oral cavity along with respiratory airflow.
Background
In modern medical technology, the medicine can directly enter the lung and be absorbed into the blood by oral or nasal inhalation, so that the first-pass effect of the liver is avoided.
Clinically, pulmonary administration is mainly used for treating pulmonary diseases such as asthma, chronic obstructive pneumonia, cystic fibrosis and the like. Due to the characteristics of thin alveolar epithelial cell wall, large surface area, low enzyme metabolic activity and the like, in recent years, a pulmonary administration mode gradually becomes a new way for non-invasive administration of more drugs (such as polypeptide drugs, protein drugs and the like).
In the pulmonary administration mode, the powder aerosol has many advantages compared with the aerosol, such as the problem that the aerosol is matched with a device by a patient in the using process can be avoided, and a propellant is not needed, so that the powder aerosol is the pulmonary inhalation preparation form with the most application prospect at present.
An aerosol refers to a formulation of micronized drug or drug in capsules, vesicles or multi-dose reservoirs with carriers, which is actively inhaled by the patient into the lungs using a specially designed aerosol delivery device or inhalation device (also known as an inhalation delivery device, and also known as a dry powder inhalation device or a dry powder delivery device). The inhalation powder inhalation depends on the autonomous respiration of a patient to enable the medicine powder to enter a respiratory system, and has the characteristics of convenience in carrying, low cost and strong stability. In recent years, the application range of the inhalation aerosol powder has been expanded from the traditional lung local disease therapeutic drug to the systemic administration of polypeptide proteins, antibiotics, biological drugs and cardiovascular system drugs. Especially, some biological macromolecules can achieve ideal bioavailability after inhalation-pulmonary administration of the medicine powder.
The powder aerosol drug delivery device is the core of powder aerosol development, and the quality of the design of the powder aerosol drug delivery device directly influences the lung deposition efficiency of the powder aerosol.
For dry powder aerosol drug delivery devices, there are generally two general categories: single doses and multiple doses, with multiple doses generally being subdivided into blister and reservoir types.
Reservoir-type inhalation drug delivery devices are usually provided with a powder container and a corresponding metering member by means of which the powdered medicament is dispensed from the powder container in successive doses.
One significant problem with the micron-sized powders of powder aerosol delivery devices is that they have poor flow characteristics and the powder particles have a large surface energy and tend to form "clumps" which can present significant difficulties in metering each dose of depot drug.
The applicant previously filed a chinese patent invention with an announcement date of 2015, 2, 18 and an announcement number of CN102218182B, which discloses a vibrating drug delivery device for a dry powder drug delivery device, comprising a housing, a powder storage container, a drug delivery metering assembly and a flow channel member, wherein the flow channel member is sequentially connected with a gas inlet, the drug delivery metering assembly and a suction nozzle; the invention is characterized in that an inverted cone-shaped medicine powder storage container is arranged at the upper part of a shell, a dosing metering component comprising a central rotating shaft and a quantitative medicine feeding disc is arranged below the inverted cone-shaped medicine powder storage container, a raised vibrating tooth is arranged at the outlet of the inverted cone-shaped medicine powder storage container, and a circle of raised teeth are arranged at the vertical height position of the central rotating shaft corresponding to the vibrating tooth; the vibrating teeth are matched with the raised teeth to form a vibrating component which can make the outlet of the inverted cone-shaped medicine powder storage container vibrate. Because the vibration mode of the vibration teeth-the convex teeth is adopted, the vibration dosing unit is arranged at the outlet of the powder storage (namely the inverted cone-shaped medicinal powder storage container), the magnitude of the vibration force or the vibration amplitude is irrelevant to the elastic component and is not influenced by the change of the medicinal powder storage capacity, the function of accurately metering the medicinal powder dose is realized, and the risk of over-metering dosing is avoided.
In the above technical scheme, once the design parameter (the reverse taper angle) of the reverse taper powder storage container is determined, the reverse taper powder storage container can only adapt to the medicine powder within a certain flowability range, and cannot adapt to the medicine powder with worse flowability index parameters. When the physical performance index (usually referring to the fluidity index of the medicine powder) of the filled medicine powder is changed, the metering accuracy of the medicine powder dosage (namely commonly called single dosage) in each administration process can be ensured only by redesigning the mechanical design parameters of the inverted cone-shaped medicine powder storage container and the vibration administration unit, so that the designed and produced powder aerosol administration device can only aim at the medicine powder with a narrow physical property range and does not have good medicine type adaptability and mechanical structure parameter design and adjustment convenience.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a vibrating medicine storage unit of a powder aerosol dosing device, which is characterized in that a second vibrating component, namely an inner medicine barrel, capable of synchronously and freely vibrating is arranged in a medicine powder storage container while the medicine powder storage container of the medicine storage unit is subjected to impact vibration, and the medicine powder in the medicine powder storage container is subjected to compound vibration, so that the metering accuracy of the medicine powder amount supplied by the medicine storage unit in each dosing process of the whole powder aerosol dosing device is better ensured, the workload of mechanical structure design change required by the change of filled medicine powder varieties can be reduced, and the good adaptability of the powder aerosol dosing device to a wider range of powder medicament varieties is increased.
The technical scheme of the invention is as follows: the vibration medicine storage unit of the powder aerosol medicine feeding device is provided, the powder aerosol medicine feeding device comprises a medicine powder storage container and a medicine feeding metering component which are arranged in a shell of the medicine feeding device, a suction nozzle is arranged on the outer side of the shell, a flow passage component is arranged in the shell, and the flow passage component is sequentially connected with an air inlet, the medicine feeding metering component and the suction nozzle through an air path; the method is characterized in that:
the shell consists of an upper cover, a middle shell and a lower shell, and a spiral cover is sleeved on the lower shell;
the spiral cover is sequentially provided with a spring, a vibration gear and a turntable;
the spring is sleeved on the central rotating shaft of the vibration gear;
a circle of raised lower vibrating teeth are arranged on the upper end surface of the vibrating gear;
a circle of raised upper vibrating teeth are arranged on the lower end face of the turntable; a pawl is arranged on the outer circumference of the turntable;
a plurality of quantitative medicine grooves are formed in the upper end face of the rotary table, and are uniformly distributed along the circumference of the rotary table by taking the central shaft of the rotary table as the circle center;
a runner lower component and a runner upper component are arranged above the turntable and are fixedly connected into a whole to form a complete runner gas circuit;
a medicine powder storage container is arranged on the lower flow passage component;
the medicine powder storage container at least comprises an outer medicine cylinder fixedly connected to the lower flow passage component;
the vibration gear serves as a main vibration component;
the rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow channel form a vibration medicine storage unit of the powder inhalation administration device;
the lower end of the outer cartridge is provided with a lower opening end penetrating through the lower flow passage component, and the lower opening end is positioned on the circumference of the upper end surface of the rotary table where a plurality of quantitative medicine grooves are distributed;
when the rotary cover rotates along a first rotating direction, the vibration gear is driven to rotate, at the moment, the rotary disc does not rotate under the limiting action of the pawl arranged on the circumference of the rotary disc, relative motion is generated between the vibration gear and the rotary disc, because the upper vibration teeth and the lower vibration teeth are respectively arranged on the combined end surface of the vibration gear and the rotary disc, when the vibration gear and the rotary disc generate coaxial relative rotation, under the elastic force action of the spring, the upper vibration teeth and the lower vibration teeth generate mutual staggering, so that the vibration gear continuously knocks the rotary disc to generate a vibration effect, the vibration effect is transmitted to an outer medicine cylinder on a lower component of the flow channel through the rotary disc to generate a first heavy vibration effect, so that medicine powder in the medicine powder storage container can uniformly and stably flow into the quantitative medicine groove, and the powder aerosol dosing device can be ensured to be in each dosing process, the metering accuracy of the single dose of the medicinal powder supplied by the medicinal powder storage container.
Further, an inner medicine cylinder is arranged in the outer medicine cylinder, the inner medicine cylinder is nested in the outer medicine cylinder, and the inner medicine cylinder can freely move in the outer medicine cylinder;
the inner medicine cylinder is of a hollow tubular structure, the diameter of the lower end of the inner medicine cylinder is smaller than that of the upper end of the inner medicine cylinder, and the longitudinal section structure of the wall of the inner medicine cylinder is of an inverted isosceles trapezoid structure with a large upper part and a small lower part;
the rotary cover, the spring, the vibrating gear, the rotary disc and the inner and outer medicine barrels arranged on the lower component of the flow passage form a composite vibrating medicine storage unit of the powder inhalation administration device;
the vibration gear serves as a main vibration part, and the inner medicine barrel serves as a secondary vibration part;
when the screw cap rotates along the first rotating direction, the knocking vibration of the vibration gear is also transmitted to an inner medicine cylinder in the outer medicine cylinder by the rotary disc to drive the inner medicine cylinder to freely vibrate in the outer medicine cylinder; the synchronous vibration of the inner cartridge produces a secondary vibratory effect.
The vibration medicine storage unit acts as a main vibration part through the vibration gear, is right the powder storage container vibrate simultaneously, in the powder storage container, still be provided with the interior cartridge that can freely vibrate in step and act as from the vibration part, carry out compound vibration to the powder in the powder storage container to ensure better that whole powder cloud agent dosing device supplies the partial metering accuracy of single dose powder dosage, increase the good adaptability of powder cloud agent dosing device to wider range powder medicine, overcome the adverse effect that the powder that loads because the mobility is poor brings the metering accuracy of dosing.
Specifically, the upper end of outer cartridge case sets up a cartridge cover, carousel, outer cartridge case and cartridge cover constitute an enclosure space in the enclosure space, interior cartridge case can freely remove.
Specifically, the spring, the vibration gear and the turntable are coaxially arranged.
Specifically, the tooth tops of the upper and lower vibrating teeth are oppositely arranged to form a one-way ratchet wheel rotating motion pair.
Furthermore, the upper vibrating teeth are annularly and uniformly distributed on the lower end surface of the rotary table by taking the rotation center of the rotary table as the circle center; the lower vibrating teeth are annularly and uniformly distributed on the upper end surface of the vibrating gear by taking the rotating center of the vibrating gear as a circle center.
Furthermore, the upper and lower vibrating teeth are unidirectional bevel teeth.
The quantitative medicine groove is a blind hole structure arranged on the upper end face of the turntable.
Furthermore, the diameter of the opening at the lower end of the outer cartridge is smaller than that of the opening at the upper end of the outer cartridge, and the longitudinal section structure of the inner cavity of the outer cartridge is an inverted isosceles trapezoid structure with a large upper part and a small lower part.
The first rotating direction is viewed as a counterclockwise rotating direction when viewed from the top of the powder inhalation drug delivery device.
Compared with the prior art, the invention has the advantages that:
1. the vibration gear is adopted below the medicine powder outlet of the medicine powder storage container, and the rotary disc is used for carrying out integral knocking type vibration on the component below the flow passage, so that a better vibration effect can be generated, the requirement on the material strength of the vibration component can be reduced, and the design, the manufacture and the manufacturing cost of a product can be favorably reduced;
2. through the adjustment of the elasticity of the spring, the tooth height of the vibrating teeth and the mechanical structure parameters of the tooth number, the vibration strength of the powder storage container in the drug delivery device can be conveniently changed, and the structure of the vibrating component can be conveniently adjusted according to the fluidity index of the loaded powder, so that the metering accuracy of the powder aerosol drug delivery device can be better ensured, and the drug delivery device has good convenience for adjusting the vibration effect and adaptability to the types of the powder;
3. the main and auxiliary vibration component structures are adopted to generate a composite vibration effect, so that the medicine powder in the medicine powder storage container can more uniformly flow into the quantitative medicine groove, and the metering accuracy of the dosage of the single dose of medicine powder supplied by the medicine powder storage container in each medicine feeding process of the powder inhalation medicine feeding device can be better ensured.
Drawings
FIG. 1 is a schematic top view of an exploded view of the relevant elements of the powder aerosol delivery device of the present invention;
FIG. 2 is a schematic bottom view of the relevant units of the powder aerosol delivery device of the present invention in an exploded configuration;
FIG. 3 is a schematic cross-sectional view of the inner and outer cartridges, the upper and lower flow channels and the turntable in the vibrating storage unit according to the present invention;
fig. 4 is a schematic view of the assembly structure of the relevant units of the powder inhalation drug delivery device of the present invention.
In the figure, 1 is a lower shell, 3 is a rotary disc, 3a is a dosing groove, 3b is an upper vibrating tooth, 3c is a pawl, 4 is a flow passage upper component, 5 is a flow passage lower component, 6 is a middle shell, 8 is a rotary cover, 12 is a vibrating gear, 12a is a lower vibrating tooth, 13 is a spring, 14 is an inner medicine cylinder, 14a is an outer medicine cylinder, 15 is a medicine cylinder cover, and 16 is an upper cover.
Detailed Description
The invention is further illustrated with reference to the following figures and examples.
As can be seen from fig. 1 to 4, the present invention provides a vibrating medicine storage unit of a powder aerosol administration device, the powder aerosol administration device includes a medicine powder storage container and an administration metering assembly arranged in a casing of the administration device, a suction nozzle is arranged outside the casing, a flow passage component is arranged in the casing, and the flow passage component is sequentially connected with an air inlet, the administration metering assembly and the suction nozzle through an air path; the invention is characterized in that:
the shell consists of an upper cover 16, a middle shell 6 and a lower shell 1, and a screw cover 8 (shown in figure 4) is sleeved on the lower shell.
A spring 13, a vibration gear 12 and a rotary disc 3 are sequentially arranged on the spiral cover, and the spring is sleeved on a central rotating shaft of the vibration gear (see figures 1 and 2).
On the upper end face of the vibration gear, a ring of raised lower vibration teeth 12a (see fig. 1) is provided; on the lower end face of the turntable, a ring of raised upper vibrating teeth 3b (see fig. 2) is provided.
A detent stop 3c (see fig. 2) is provided on the circumference of the turntable.
The upper end face of the rotary table is provided with a plurality of quantitative medicine grooves 3a which are uniformly distributed along the circumference of the rotary table by taking the central shaft of the rotary table as the circle center.
And a lower runner component 5 and an upper runner component 4 are arranged above the turntable, and the lower runner component and the upper runner component are buckled and fixedly connected into a whole to form a complete runner gas circuit.
A medicine powder storage container is provided on the lower flow path member.
The medicine powder storage container includes at least an outer medicine container 14a fixedly attached to the lower flow path member.
The rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow passage form a vibration medicine storage unit of the powder aerosol administration device.
As a further alternative, an inner cartridge 14 can also be arranged in the outer cartridge, said inner cartridge being nested in said outer cartridge, said inner cartridge being freely movable in said outer cartridge.
The rotary cover, the spring, the vibration gear, the rotary disc and the inner and outer medicine barrels arranged on the lower component of the flow passage form a composite vibration medicine storage unit of the powder inhalation administration device.
In this alternative, the vibrating gear serves as the primary vibrating member and the inner cartridge serves as the secondary vibrating member.
In this alternative, the powder aerosol medicament powder (or called medicament powder) filled in the outer cartridge may be further more fully vibrated by the free movement of the inner cartridge in the outer cartridge.
Since the inner drug cylinder in the outer drug cylinder is not a necessary basic component and belongs to an optional component, in the expression of the technical scheme, except for the specific points, all the other parts related to the vibration drug storage unit of the aerosol drug delivery device can be regarded as common descriptions of the vibration drug storage unit without the inner drug cylinder or the composite vibration drug storage unit with the inner drug cylinder, and are not described separately to avoid repetition.
When the structure of the medicine powder storage container only comprises an outer medicine cylinder fixedly connected to the lower component of the flow channel, the rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow channel form a vibration medicine storage unit of the powder aerosol administration device; the vibration gear is a main vibration part.
When the structure that the inner medicine cylinder is arranged in the outer medicine cylinder is adopted, the spiral cover, the spring, the vibration gear, the rotary disc and the inner medicine cylinder and the outer medicine cylinder which are arranged on the lower component of the flow passage form a composite vibration medicine storage unit of the powder inhalation medicine feeding device; the vibrating gear serves as a main vibrating part, and the inner medicine cylinder serves as a secondary vibrating part.
The lower end of the outer cartridge case is provided with a lower opening end penetrating through the lower flow passage component, and the lower opening end is positioned on the circumference where the plurality of quantitative medicine grooves on the upper end surface of the rotary table are distributed.
The lower flow passage component, the rotary disc, the quantitative medicine groove, the outer medicine cylinder and the inner medicine cylinder form a medicine feeding metering component of the powder aerosol medicine feeding device.
In the practical operation process, when the rotary cap 8 rotates along a first rotation direction (counterclockwise from the top view of the powder aerosol administration device) to a certain angle (called as a first rotation angle, such as 60 °), the rotary cap will drive the vibration gear 12 to rotate, at this time, the rotary disk cannot rotate under the limit action of the three pawls 3c arranged on the circumference of the rotary disk, and the vibration gear and the rotary disk generate relative motion (coaxial reverse rotation), because the upper and lower vibration teeth 3b and 12a are respectively arranged on the combined end surface of the vibration gear and the rotary disk, when the relative motion (coaxial reverse rotation) is generated between the vibration gear and the rotary disk, under the elastic force of the spring 13, the two sets of vibration teeth 3b and 12a generate mutual dislocation, so that the vibration gear continuously strikes the rotary disk, and generates a vibration effect, which is transmitted to the outer cartridge located on the lower component of the flow channel through the rotary disk, a first heavy vibration effect is produced.
When the structure of the composite vibration medicine storage unit is adopted, the rotary disc can synchronously transmit the knocking vibration of the vibration gear to the inner medicine cylinder positioned in the outer medicine cylinder while generating a first heavy vibration effect, and the inner medicine cylinder is driven to freely vibrate in the outer medicine cylinder; the synchronous vibration of the inner medicine cylinder produces a second vibration effect, so that the medicine powder in the medicine powder storage container can flow into the quantitative medicine groove more uniformly and stably, and the metering accuracy of the single dose of medicine powder supplied by the medicine powder storage container can be better ensured in each medicine feeding process of the powder inhalation medicine feeding device.
The quantity and the height of the vibration teeth and the elasticity of the spring can be changed to adjust the strength of the whole vibration effect of the medicine storage unit, and the metering accuracy of the medicine powder adding amount is improved.
The dosage metering accuracy of single dose of medicinal powder can be further adjusted and ensured by adjusting the included angle of the bottom edges of the inner and outer medicament cylinders and the mass of the inner medicament cylinder according to the fluidity index of the medicinal powder, so that the powder inhalation drug delivery device has good adaptability to the types of medicinal powder and convenience in design and adjustment of mechanical structure parameters.
In the technical scheme of the invention, the vibrating medicine storage unit is used as a main vibrating part through a vibrating gear to vibrate the medicine powder storage container, and simultaneously, an inner medicine cylinder capable of synchronously and freely vibrating is also arranged in the medicine powder storage container to be used as an auxiliary vibrating part to carry out compound vibration on medicine powder in the medicine powder storage container, so that the metering accuracy of single-dose medicine powder supplied by the whole powder aerosol dosing device is better ensured, the good adaptability of the powder aerosol dosing device to various medicine powder types is increased, and the adverse influence of poor flowability of powder on the dosing accuracy is overcome.
As can be seen from fig. 3, a cartridge cover 15 is provided at the upper end of the outer cartridge, and the turntable, the outer cartridge and the cartridge cover form a closed space in which the inner cartridge can move freely, which may be a longitudinal movement of the inner cartridge along the longitudinal axis of the outer cartridge, a lateral movement of the inner cartridge in the outer cartridge, a combination of a longitudinal and a lateral movement of the inner cartridge in the outer cartridge, or an irregular movement of the inner cartridge in the outer cartridge.
The inner medicine barrel can freely move in the outer medicine barrel, so that the powder inhalation medicine powder (or called medicine powder) filled in the outer medicine barrel can be sufficiently vibrated, and can more uniformly and stably flow into the quantitative medicine groove.
As can be seen from fig. 1, 2 or 4, the spring, the oscillating gear and the turntable are arranged coaxially.
As shown in figures 1 and 2, the tooth tips of the upper and lower vibrating teeth are oppositely arranged to form a unidirectional ratchet wheel rotating pair.
Furthermore, the upper vibrating teeth are annularly and uniformly distributed on the lower end surface of the rotary table by taking the rotation center of the rotary table as the circle center; the lower vibrating teeth are annularly and uniformly distributed on the upper end surface of the vibrating gear by taking the rotating center of the vibrating gear as a circle center.
As shown in fig. 1 and 2, the upper and lower vibrating teeth are unidirectional bevel teeth.
Since the two sets of unidirectional bevel teeth with opposite tooth tips are used for generating impact and knocking vibration, which are common means in mechanical design, the action principle, process and vibration generation mechanism are not described herein.
According to the technical scheme, the runner lower member is subjected to integral knocking type vibration through the turntable, so that a better integral vibration effect can be generated, the requirement on the material strength of the vibration member can be lowered, and the design, the manufacture and the manufacturing cost of a product can be favorably reduced; the main and auxiliary vibrating component structures are adopted to carry out compound vibration on the medicine storage unit, so that the metering accuracy of the medicine powder amount supplied by the medicine storage unit in each administration process of the whole powder inhalation administration device can be better ensured; through the arrangement of the inner medicine cylinder, the workload of mechanical structure design change required by the change of the flowability of the filled medicine powder can be reduced, the good adaptability of the powder inhalation dosing device to a wider range of medicine powder types is increased, and the adverse effect on the dosing accuracy caused by the poor flowability of the powder inhalation dosing device is overcome.
The invention can be widely applied to the design and manufacture fields of powder aerosol administration devices with various specifications.
Claims (11)
1. A vibration medicine storage unit of a powder aerosol administration device comprises a medicine powder storage container and an administration metering component which are arranged in a shell of the administration device, wherein a suction nozzle is arranged on the outer side of the shell, a flow passage component is arranged in the shell, and the flow passage component is sequentially connected with an air inlet, the administration metering component and the suction nozzle through an air path; the shell consists of an upper cover, a middle shell and a lower shell, and a spiral cover is sleeved on the lower shell; a spring, a vibration gear and a turntable are sequentially arranged on the rotary cover; the spring is sleeved on the central rotating shaft of the vibration gear; a circle of raised lower vibrating teeth are arranged on the upper end surface of the vibrating gear; a circle of raised upper vibration teeth are arranged on the lower end surface of the turntable; a pawl is arranged on the outer circumference of the turntable; a plurality of quantitative medicine grooves are formed in the upper end face of the rotary table and are uniformly distributed along the circumference of the rotary table by taking the central shaft of the rotary table as a circle center; a runner lower component and a runner upper component are arranged above the turntable, and the runner lower component and the runner upper component are buckled and fixedly connected into a whole to form a complete runner gas circuit; the method is characterized in that:
a medicine powder storage container is arranged on the lower flow passage component;
the medicine powder storage container at least comprises an outer medicine cylinder fixedly connected to the lower flow passage component;
the rotary cover, the spring, the vibration gear, the rotary disc and the outer medicine cylinder arranged on the lower component of the flow channel form a vibration medicine storage unit of the powder inhalation administration device;
the lower end of the outer cartridge is provided with a lower opening end penetrating through the lower flow passage component, and the lower opening end is positioned on the circumference of the upper end surface of the rotary table where a plurality of quantitative medicine grooves are distributed;
when the rotary cover rotates along a first rotating direction, the vibration gear is driven to rotate, at the moment, the rotary disc does not rotate under the limiting action of the pawl arranged on the circumference of the rotary disc, relative motion is generated between the vibration gear and the rotary disc, because the upper vibration teeth and the lower vibration teeth are respectively arranged on the combined end surface of the vibration gear and the rotary disc, when the vibration gear and the rotary disc generate coaxial relative rotation, under the elastic force action of the spring, the upper vibration teeth and the lower vibration teeth generate mutual staggering, so that the vibration gear continuously knocks the rotary disc to generate a vibration effect, the vibration effect is transmitted to an outer medicine cylinder on a lower component of the flow channel through the rotary disc to generate a first heavy vibration effect, so that medicine powder in the medicine powder storage container can uniformly and stably flow into the quantitative medicine groove, and the powder aerosol dosing device can be ensured to be in each dosing process, the metering accuracy of the single dose of the medicinal powder supplied by the medicinal powder storage container;
an inner medicine cylinder is arranged in the outer medicine cylinder, and the inner medicine cylinder can freely move in the outer medicine cylinder;
the rotary cover, the spring, the vibrating gear, the rotary disc and the inner and outer medicine barrels arranged on the lower component of the flow passage form a composite vibrating medicine storage unit of the powder inhalation administration device;
the vibration gear serves as a main vibration part, and the inner medicine barrel serves as a secondary vibration part;
when the screw cap rotates along the first rotating direction, the knocking vibration of the vibration gear is also transmitted to an inner medicine cylinder in the outer medicine cylinder by the rotary disc to drive the inner medicine cylinder to freely vibrate in the outer medicine cylinder; the synchronous vibration of the inner cartridge produces a secondary vibratory effect.
2. The vibratory drug storage unit for a dry powder aerosol delivery device of claim 1 wherein said inner cartridge is nested within said outer cartridge;
the inner medicine cylinder is of a hollow tubular structure, the diameter of the lower end of the inner medicine cylinder is smaller than that of the upper end of the inner medicine cylinder, and the longitudinal section structure of the wall of the inner medicine cylinder is of an inverted isosceles trapezoid structure with a large upper part and a small lower part.
3. The vibrating medicine storage unit of a powder inhalation drug delivery device as claimed in claim 1, wherein the vibrating medicine storage unit is provided with an inner medicine cylinder capable of vibrating freely and synchronously as a secondary vibrating member in the medicine powder storage container while vibrating the medicine powder storage container by means of a vibrating gear as a primary vibrating member, so as to perform combined vibration of the medicine powder in the medicine powder storage container, to thereby better ensure the accuracy of the metering of the single dose of medicine powder supplied to the whole powder inhalation drug delivery device, to thereby increase the adaptability of the powder inhalation drug delivery device to a wider range of medicine powder, and to overcome the adverse effect of the poor flowability of the filled medicine powder on the accuracy of the metering.
4. The vibratory cartridge storage unit for a dry powder inhalation delivery device of claim 1 wherein a cartridge cover is provided at the upper end of said outer cartridge, said turntable, outer cartridge and cartridge cover defining an enclosed space in which said inner cartridge is freely movable.
5. The vibratory cartridge for a dry powder inhalation delivery device of claim 1 wherein said spring, vibratory gear and dial are coaxially disposed.
6. The vibratory medicine storage unit for a dry powder inhalation delivery device as claimed in claim 1, wherein the tips of said upper and lower vibratory teeth are disposed in opposition to each other to form a unidirectional ratcheting pair.
7. The vibrating medicine storage unit of a dry powder inhalation drug delivery device according to claim 1, wherein the upper vibrating teeth are annularly and uniformly distributed on the lower end surface of the rotary table with the center of rotation of the rotary table as the center of circle; the lower vibrating teeth are annularly and uniformly distributed on the upper end surface of the vibrating gear by taking the rotating center of the vibrating gear as a circle center.
8. The vibratory cartridge for a dry powder inhalation delivery device of claim 1 wherein said upper and lower vibratory teeth are single ramped teeth.
9. The vibratory medicine storage unit for a dry powder inhalation delivery device of claim 1, wherein said dosing chamber is a blind hole structure disposed on the upper end surface of the turntable.
10. The vibration medicine storage unit of a dry powder inhalation drug delivery device according to claim 1, wherein the diameter of the lower end opening of said outer cartridge is smaller than the diameter of the upper end opening of said outer cartridge, and the longitudinal cross-sectional structure of the inner cavity of said outer cartridge is an inverted isosceles trapezoid structure with a large upper part and a small lower part.
11. The vibratory medicine storage unit for a dry powder aerosol delivery device as claimed in claim 1, wherein the first rotational direction is viewed as a counterclockwise rotational direction from the top of the dry powder aerosol delivery device.
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| CN110464929B (en) * | 2019-08-30 | 2021-09-10 | 上海新黄河制药有限公司 | Method for prolonging service life of storage type dry powder inhalation drug delivery device |
| CN110464930B (en) * | 2019-08-30 | 2021-09-10 | 上海新黄河制药有限公司 | Coaxial vibration gear for vibration administration unit of storage type dry powder inhalation administration device |
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| CN102218182A (en) * | 2011-06-13 | 2011-10-19 | 上海秀新臣邦医药科技有限公司 | Vibrating dosing device for dry power dosing device |
| CN102228725A (en) * | 2011-06-13 | 2011-11-02 | 上海秀新臣邦医药科技有限公司 | Dry powder administration device |
-
2015
- 2015-06-30 CN CN201510373606.4A patent/CN104971412B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1810312A (en) * | 1997-03-14 | 2006-08-02 | 阿斯特拉公司 | Inhalation device |
| GB2364649A (en) * | 2000-05-17 | 2002-02-06 | Orion Corp | Inhaler with Dose Counter |
| WO2007045904A1 (en) * | 2005-10-22 | 2007-04-26 | 42 Technology Limited | Dose counter for inhalation devices |
| CN102218182A (en) * | 2011-06-13 | 2011-10-19 | 上海秀新臣邦医药科技有限公司 | Vibrating dosing device for dry power dosing device |
| CN102228725A (en) * | 2011-06-13 | 2011-11-02 | 上海秀新臣邦医药科技有限公司 | Dry powder administration device |
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| Publication number | Publication date |
|---|---|
| CN104971412A (en) | 2015-10-14 |
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