CN104971295B - A kind of Chinese medicine composition and its application in preparing sargassum fusifome nutritious lotus seed wine - Google Patents

A kind of Chinese medicine composition and its application in preparing sargassum fusifome nutritious lotus seed wine Download PDF

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CN104971295B
CN104971295B CN201510368801.8A CN201510368801A CN104971295B CN 104971295 B CN104971295 B CN 104971295B CN 201510368801 A CN201510368801 A CN 201510368801A CN 104971295 B CN104971295 B CN 104971295B
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CN104971295A (en
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范铮
张国亮
秦磊
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Zhejiang University of Technology ZJUT
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Abstract

A kind of application the invention discloses Chinese medicine composition and its in preparing sargassum fusifome nutritious lotus seed wine, the Chinese medicine composition are made of the raw material of following weight proportion:10 parts of sargassum fusifome, 3~8 parts of sea cucumber, 2~8 parts of oyster, 6~20 parts of lotus seeds, 8~18 parts of glutinous rehmannia, 4~9 parts of the fruit of Chinese wolfberry, 3~8 parts of Radix Angelicae Sinensis, 3~8 parts of Radix Glycyrrhizae, 3~8 parts of Radix Salviae Miltiorrhizae, 4~6 parts of Cortex Eucommiae, 4~8 parts of ligustrazine, 1~3 part of cassia bark, 2~4 parts of old ginger, 2~4 parts of Amomum cardamomum;Thick many candies yield improves 36.7%, protein content and improves 16.3%, fat content raising 14.5% in the nourishment wine prepared using the Chinese medicine composition.

Description

A kind of Chinese medicine composition and its application in preparing sargassum fusifome nutritious lotus seed wine
(1) technical field
The present invention relates to a kind of Chinese medicine composition and the application of nourishment wine is prepared, more particularly to it is viscous can to reduce blood for one kind Degree reduces thrombus, cerebral hemorrhage risk, alleviates hypertensive patient's symptom, physical and mental health, the sargassum fusifome nutritious lotus seed for improving immunity The preparation method of wine.
(2) background technology
People require increasingly to be promoted to life, for the needs of care concepts and highly intensive labour, to edible natural, nutrition The requirement of invigorant increasingly improve.Current marine food is increasingly subject to the high praise of people, although marine organisms quantity is very It is more, but edible inconvenience.The less varieties that product by processing can be selected, product on the market is often inconvenient to carry, and Nutrition is single.Marine organisms and medical and edible dual purpose plant are carried out reasonable compatibility by the present invention.Finishing is carried out using modern processing Work is taken into account in edible, nutrition and taste etc., and various aspects comprehensive consideration reaches preferable effect.
Marine organisms such as sargassum fusifome waste material produces ethyl alcohol, and such as patent 200710014246, this method is waste utilization production Ethyl alcohol and feed.Sea cucumber has the patent of direct processing and eating, such as 201210397241.5 is decomposed by high temperature and pressure, cooks congee, does A variety of sea cucumber fourths.There is the method directly impregnated, the patent No. 200410066342.X such as detected, using lotus seeds as raw material. The technique that alcoholic is carried out liquid fermentation after immersion, but extraction is often incomplete, therefore promoted using pectase, cellulase, head mold It is further decomposed into active ingredient in the raw materials such as sargassum fusifome, sea cucumber, oyster, lotus seeds;After the medicinal material impregnated and vinasse mixing The method of fermentation, the effective component extracted is more, while making delicate flavour material, the fragrance ingredient of wine body more rich;Ocean Drug fishy smell is heavier, by the mixing with vinasse, so that a large amount of fishy smell substance in marine organisms is absorbed by vinasse, improves wine Mouthfeel.Sargassum fusifome nutritious lotus seed wine of the present invention can improve the immunocompetence of people, and brain-care, the Product Safety is high, practical It is convenient.
(3) invention content
It is an object of the present invention to provide a kind of Chinese medicine composition and its application in sargassum fusifome nutritious lotus seed wine is prepared, the present invention Sargassum fusifome nourishment wine alcoholic strength temperature compensation, nutrition comprehensively, clean taste, wine body it is limpid, effect is to reduce blood viscosity, reduces blood Bolt, alleviates hypertensive patient's symptom at cerebral hemorrhage risk, and having improves blood circulation of human body, brain-nourishing intelligence-benefiting, and strengthen immunity etc. has Effect.
The technical solution adopted by the present invention is:
The present invention provides a kind of Chinese medicine composition, and the Chinese medicine composition is made of the raw material of following weight proportion:Sheep dwells 10 parts of dish, 3~8 parts of sea cucumber, 2~8 parts of oyster, 6~20 parts of lotus seeds, 8~18 parts of glutinous rehmannia, 4~9 parts of the fruit of Chinese wolfberry, 3~8 parts of Radix Angelicae Sinensis, 3~8 parts of Radix Glycyrrhizae, 3~8 parts of Radix Salviae Miltiorrhizae, 4~6 parts of Cortex Eucommiae, 4~8 parts of ligustrazine, 1~3 part of cassia bark, 2~4 parts of old ginger and Amomum cardamomum 2 ~4 parts.
Further, the preferably described Chinese medicine composition is made of the raw material of following weight proportion:10 parts of sargassum fusifome, sea cucumber 4~5 Part, 3~5 parts of oyster, 10~12 parts of lotus seeds, 10~12 parts of glutinous rehmannia, 4~6 parts of the fruit of Chinese wolfberry, 3~5 parts of Radix Angelicae Sinensis, 4~6 parts of Radix Glycyrrhizae, pellet 2~3 parts of 3~4 parts of ginseng, 4~5 parts of Cortex Eucommiae, 6~8 parts of ligustrazine, 1~2 part of cassia bark, 3~4 parts of old ginger and Amomum cardamomum.
It is specific described the present invention also provides a kind of application of Chinese medicine composition in preparing sargassum fusifome nutritious lotus seed wine Application process be:(1) by the Chinese medicine composition of formula ratio soaking in Chinese liquor 7-10 days, filtering obtains immersion wine liquid and filter residue; (2) it is used as fermentation substrate after the filter residue and lees of yellow wine mixing that obtain step (1), accesses pectase and cellulase, stirring Mixing, 50 DEG C keep 12h postcoolings to room temperature, and access head mold, wheat koji and distiller's yeast, 50 DEG C are kept for 50 days, and uploading in rice steamer distillation must distill Wine liquid;The filter residue is 1 with lees of yellow wine weight ratio:5~10 (preferably 1:7~10);The pectase quality addition is to send out Ferment matrix weight is calculated as 1~1.5% (preferably 1~1.2%), and the cellulase quality addition is calculated as with fermentation substrate weight 1~2% (preferably 1.2~1.8%), the head mold quality addition are calculated as 0.8~1.5% (preferably 0.8 with fermentation substrate weight ~1.0%), the wheat koji quality addition is calculated as 1.0~2.5% (preferably 1.5~2.0%), described with fermentation substrate weight Distiller's yeast quality addition is calculated as 2~4% (preferably 3.0~3.2%) with fermentation substrate weight;(3) distillation for obtaining step (2) Wine liquid filters after being mixed with the immersion wine liquid that step (1) obtains, and filtrate is taken to obtain sargassum fusifome nutritious lotus seed wine.
Further, soaking in Chinese liquor method is in preferred steps (1):Chinese medicine composition is first subjected to first time leaching with white wine Bubble, first time soaking time are 7 days, and filtering obtains first time filtrate and first time filter residue, then adds again into first time filter residue Enter white wine and carry out second of immersion, second of soaking time is 3 days, and filtering obtains second of filtrate and second of filter residue, merges First time filtrate and second of filtrate are immersion wine liquid, and second of filter residue is used to be mixed and made into fermentation substrate with lees of yellow wine; White wine volumetric usage used being impregnated for the first time, 5ml/g being calculated as with Chinese medicine composition weight, second of immersion white wine volume used is used Amount is calculated as 5ml/g with Chinese medicine composition weight, and the white wine is that grain is burnt.
Further, white wine is that 53 ° of grains are burnt in preferred steps (1).
Further, filter residue described in preferred steps (2) and lees of yellow wine weight ratio are 1:8.Huang may be used in lees of yellow wine Vinasse after wine squeezing, or the ripe vinasse after grain burns distillation, preferably lees of yellow wine are that grain burns single flash after-ripening vinasse.
Further, pectase quality addition described in preferred steps (2) is calculated as 1% with fermentation substrate weight, the fibre The plain enzyme quality addition of dimension is calculated as 1.5% with fermentation substrate weight.
Further, head mold quality addition described in preferred steps (2) is calculated as the 0.8%, wheat with fermentation substrate weight Qu Zhiliang additions are calculated as 1.8%, the distiller's yeast quality addition with fermentation substrate weight and are calculated as with fermentation substrate weight 3.0%.
Further, filtering is that will distill after wine liquid mixes with immersion wine liquid in preferred steps (3), is had using 0.45 μm of micropore Machine microfiltration membranes are filtered by vacuum, and filtrate is sargassum fusifome nutritious lotus seed wine.
The enzyme activity 20000U/g of pectase of the present invention, the enzyme activity 16000U/g of cellulase, the enzyme activity of head mold 3500U/g, the liquefaction enzyme activity 15g/gh of wheat koji, saccharification enzyme activity 800mg/gh, distiller's yeast are made a living cooking wine mother.
Sargassum fusifome of the present invention is preferably the produced sargassum fusifome in Wenzhou City, Zhejiang Province Dongtou County, and the sea cucumber is preferably The produced sea cucumber in Daliang City of Liaoning Province, the oyster are preferably clean dried oyster, the grain burning preferably institute of Shaoxing brewery 53 ° of grains of production are burnt.
Compared with prior art, the beneficial effects are mainly as follows:The present invention provide a kind of Chinese medicine composition and Its application in preparing sargassum fusifome nutritious lotus seed wine is improved using Thick many candies yield in the nourishment wine of Chinese medicine composition preparation 36.7% (using sulfuric acid-green onion ketone method), protein content improve 16.3% (using GB/T 5009.5-2010), fat content carries High by 14.5% (using GB/T 5009.5-2003).Sargassum fusifome nourishment wine alcoholic strength temperature compensation of the present invention, nutrition comprehensively, clean taste, Wine body is limpid, and effect is to reduce blood viscosity, reduces thrombus, cerebral hemorrhage risk, alleviates hypertensive patient's symptom, having improves Blood circulation of human body, brain-nourishing intelligence-benefiting, strengthen immunity etc. are powerful.
(4) specific implementation mode
With reference to specific embodiment, the present invention is described further, but protection scope of the present invention is not limited in This:
Sargassum fusifome described in the embodiment of the present invention produces sargassum fusifome by Wenzhou City, Zhejiang Province Dongtou County, and the sea cucumber is Liaoning The produced sea cucumber in Daliang City of province, the oyster are clean dried oyster, and the Chinese medicine meets《Pharmacopoea Chinensis》It is required that.
It is preferably that Shaoxing brewery produces 53 ° of grain burnings that the grain, which is burnt, and lees of yellow wine is preferably after primary grain is burnt and distilled Vinasse.
Embodiment 1:
(1) Traditional Chinese medicine composition formula:Sargassum fusifome 12g, sea cucumber 5g, oyster 5g, lotus seeds 14g, glutinous rehmannia 16g, fruit of Chinese wolfberry 7g, when Return 8g, Radix Glycyrrhizae 4g, Radix Salviae Miltiorrhizae 5g, Cortex Eucommiae 6g, ligustrazine 7g, cassia bark 2g, old ginger 3g, Amomum cardamomum 3g.
(2) it pre-processes:According to step (1) formula ratio, clean sargassum fusifome, sea cucumber, oyster are smashed;By lotus seeds, glutinous rehmannia, The fruit of Chinese wolfberry, Radix Angelicae Sinensis, Radix Glycyrrhizae, Radix Salviae Miltiorrhizae, Cortex Eucommiae, ligustrazine, cassia bark, old ginger, Amomum cardamomum are cleaned, smash, and are heated 15 minutes with steam Sterilizing is packed into cylinder.
(3) step (2) pretreated Chinese medicine composition is pressed to be burnt with 53 ° of grains of 500ml per 100g and is impregnated, often for the first time Temperature is impregnated 7 days, obtains first time filtrate and first time filter residue with 5 layers of filtered through gauze, 500ml then is added into first time filter residue again 53 ° of grains burn into second of soak at room temperature of row 3 days, obtain second of filtrate with 5 layers of filtered through gauze, merge first time filtrate and second Filtrate (i.e. immersion wine liquid), takes filter residue for use;
(4) lees of yellow wine is cooled to 52~55 DEG C, by step (3) filter residue with 1:8 (filter residues:Lees of yellow wine mass ratio) ratio Fermentation substrate is made in example mixing, by per 1000g fermentation substrate access 10g pectases (enzyme activity 20000U/g), 15g cellulases (enzyme activity 16000U/g), 50 DEG C of mixing keeps 12h postcoolings to room temperature, then accesses 8g head molds (enzyme activity 3500U/g), 18g wheat kojis (liquefaction enzyme activity 15g/gh, saccharification enzyme activity 800mg/gh), 30g distiller's yeasts (raw material distiller's yeast).Even, control is turned within first 10 days once a day 32~35 DEG C of temperature processed, centre are turned over even primary for every 2 days 10 days, keep 30~32 DEG C of temperature, and standing is not stirred within latter 10 days, at 30 days Between after uploading in rice steamer, obtain distillation wine liquid;
(5) distillation wine liquid is mixed with immersion wine liquid, is taken out using the 0.45 μm of organic microfiltration membranes of micropore (millipore) vacuum Filter, filtrate is sargassum fusifome nutritious lotus seed wine (former wine).
Thick many candies yield improves 36.7% (using sulfuric acid-green onion ketone method) in nourishment wine, protein content improves 16.3% and (adopts With GB/T 5009.5-2010), fat content improve 14.5% (use GB/T 5009.5-2003).
Embodiment 2
Step (2), step (3) and step (5) method and operation with embodiment 1, unlike:
(1) Traditional Chinese medicine composition formula:Weigh sargassum fusifome 15g, sea cucumber 8g, oyster 6g, lotus seeds 10g, glutinous rehmannia 14g, the fruit of Chinese wolfberry 7g, Radix Angelicae Sinensis 7g, Radix Glycyrrhizae 8g, Radix Salviae Miltiorrhizae 5g, Cortex Eucommiae 6g, ligustrazine 9g, cassia bark 2g, old ginger 5g, Amomum cardamomum 4g.
(4) lees of yellow wine is taken to be cooled to 52~55 DEG C, by step (3) filter residue with 1:10 (filter residues:Lees of yellow wine) ratio is mixed It is even that fermentation substrate is made, by per 1000g fermentation substrate access pectase 12g (enzyme activity 20000U/g), cellulase 18g (enzyme activity 16000U/g), 50 DEG C of mixing keeps 12h postcoolings to 25 DEG C, access head mold 10g (enzyme activity 3500U/g), wheat koji 20g (α-amylases Living 15g/gh, saccharification enzyme activity 800mg/gh), distiller's yeast 30g (raw material distiller's yeast).Even, control temperature is turned within first 10 days once a day 32~35 DEG C, centre is turned over even primary for every 2 days 10 days, keeps 30~32 DEG C of temperature, and standings is not stirred within latter 10 days, latter 10 days standings, Uploading in rice steamer after 32 day time, obtains distillation wine liquid.
Thick many candies yield improves 34.5% (using sulfuric acid-green onion ketone method) in nourishment wine, protein content improves 15.2% and (adopts With GB/T 5009.5-2010), fat content improve 13.9% (use GB/T 5009.5-2003).
Embodiment 3
Step (2), step (3) and step (5) method and operation with embodiment 1, unlike:
(1) Traditional Chinese medicine composition formula:Weigh sargassum fusifome 10g, sea cucumber 4g, oyster 4g, lotus seeds 16g, glutinous rehmannia 18g, the fruit of Chinese wolfberry 8g, Radix Angelicae Sinensis 7g, Radix Glycyrrhizae 4g, Radix Salviae Miltiorrhizae 5g, Cortex Eucommiae 6g, ligustrazine 7g, cassia bark 2g, old ginger 3g, Amomum cardamomum 3g.
(4) lees of yellow wine is taken to be cooled to 52~55 DEG C, by step (3) filter residue with weight ratio 1:7 (filter residues:Lees of yellow wine) ratio Fermentation substrate is made in example mixing, by per 1000g fermentation substrate access pectase 10g (enzyme activity 20000U/g), cellulase 12g (enzyme activity 16000U/g), mixing, 50 DEG C keep 12h postcoolings to room temperature, then access head mold 8g (enzyme activity 3500U/g), wheat koji 15g (liquefaction enzyme activity 15g/gh, saccharification enzyme activity 800mg/gh), distiller's yeast 32g (raw material distiller's yeast), turn over even one in first 10 days daily It is secondary, control 32~35 DEG C of temperature, centre is turned over even primary for every 2 days 10 days, keeps 30~32 DEG C of temperature, and standing is not stirred within latter 10 days, Uploading in rice steamer after 30 day time, obtains distillation wine liquid.
Thick many candies yield improves 37.8% (using sulfuric acid-green onion ketone method) in nourishment wine, protein content improves 17.5% and (adopts With GB/T 5009.5-2010), fat content improve 15.3% (use GB/T 5009.5-2003).
Case 1
Lee's ××, man 53 years old, dizziness, the deficiency of vital energy, neurasthenia.Daily this nourishment wine (preparation of embodiment 1) 75~100 Milliliter, is clearly better after three months, has no adverse reaction.
Case 2
Gong's ××, female 38 years old is dizziness, tinnitus, weak, daily 50~100 milli of this nourishment wine (preparation of embodiment 2) It rises.Symptom improves after two months.
Case 3
×× is opened, female 45 years old, the deficiency of vital energy, chilly, palpitaition are weak.Daily this nourishment wine (preparation of embodiment 2) 75~100 Milliliter.There is symptom to be obviously improved after three months.
Case 4
In ××, man 65 years old, irascibility rising, with hypertension symptom, daily this nourishment wine (preparation of embodiment 3) 50 Have after~100 milliliters, six months and is clearly better.Upper blood pressure is reduced to 128mmHg by 157mmHg, and lower blood pressure is reduced to by 114mmHg 83mmHg。
It is to take object with 80 patients with symptoms such as neurasthenia, dizziness, tinnitus, hypertension, in this oral hair 80~88% patient fully recovers after bright nourishment wine or the symptoms were significantly improved, and centainly improving occurs in 7%~12% patient, 5%~ 8% patient outcome is general.

Claims (10)

1. a kind of having the Chinese medicine composition for improving neurasthenia, hypertension, dizziness or tinnitus function, it is characterised in that in described Drug composition is made of the raw material of following weight proportion:10 parts of sargassum fusifome, 3 ~ 8 parts of sea cucumber, 2 ~ 8 parts of oyster, 6 ~ 20 parts of lotus seeds, 8 ~ 18 parts yellow, 4 ~ 9 parts of the fruit of Chinese wolfberry, 3 ~ 8 parts of Radix Angelicae Sinensis, 3 ~ 8 parts of Radix Glycyrrhizae, 3 ~ 8 parts of Radix Salviae Miltiorrhizae, 4 ~ 6 parts of Cortex Eucommiae, 4 ~ 8 parts of ligustrazine, cassia bark 2 ~ 4 parts of 1 ~ 3 part, 2 ~ 4 parts of old ginger and Amomum cardamomum.
2. Chinese medicine composition as described in claim 1, it is characterised in that the Chinese medicine composition by following weight proportion raw material Composition:10 parts of sargassum fusifome, 4 ~ 5 parts of sea cucumber, 3 ~ 5 parts of oyster, 10 ~ 12 parts of lotus seeds, 10 ~ 12 parts of glutinous rehmannia, 4 ~ 6 parts of the fruit of Chinese wolfberry, Radix Angelicae Sinensis 3 ~ 5 parts, 4 ~ 6 parts of Radix Glycyrrhizae, 3 ~ 4 parts of Radix Salviae Miltiorrhizae, 4 ~ 5 parts of Cortex Eucommiae, 6 ~ 8 parts of ligustrazine, 1 ~ 2 part of cassia bark, 3 ~ 4 parts of old ginger and Amomum cardamomum 2 ~ 3 Part.
3. Chinese medicine composition described in a kind of claim 1 has the function of to improve neurasthenia, hypertension, dizziness or tinnitus in preparation Sargassum fusifome nutritious lotus seed wine in application.
4. application as claimed in claim 3, it is characterised in that the preparation method of sargassum fusifome nutritious lotus seed wine is:(1)It will formula The Chinese medicine composition of amount soaking in Chinese liquor 7-10 days, filtering obtain immersion wine liquid and filter residue;(2)By step(1)The filter residue of acquisition With fermentation substrate is used as after lees of yellow wine mixing, access pectase and cellulase, stir and evenly mix, 50 DEG C of holding 12h postcoolings To room temperature, then head mold, wheat koji and distiller's yeast are accessed, 50 DEG C are kept for 50 days, and uploading in rice steamer distillation obtains distillation wine liquid;The filter residue and yellow rice wine Vinasse weight ratio is 1:5~10;The pectase quality addition is calculated as 1 ~ 1.5% with fermentation substrate weight, the cellulase Quality addition is calculated as 1 ~ 2% with fermentation substrate weight, and the head mold quality addition is calculated as 0.8 with fermentation substrate weight ~ 1.5%, the wheat koji quality addition is calculated as 1.0 ~ 2.5%, the distiller's yeast quality addition with the base that ferments with fermentation substrate weight Matter weight is calculated as 2 ~ 4%;(3)By step(2)The distillation wine liquid and step of acquisition(1)It filters, takes after the immersion wine liquid mixing of acquisition Filtrate obtains sargassum fusifome nutritious lotus seed wine.
5. application as claimed in claim 4, it is characterised in that step(1)Middle soaking in Chinese liquor method is:First by Chinese medicine composition First time immersion is carried out with white wine, first time soaking time is 7 days, and filtering obtains first time filtrate and first time filter residue, then White wine is added into first time filter residue again and carries out second of immersion, second of soaking time is 3 days, and filtering obtains second of filter Liquid and second of filter residue, it is immersion wine liquid to merge first time filtrate and second of filtrate;White wine volume used is impregnated for the first time Dosage is calculated as 5ml/g with Chinese medicine composition weight, and second of immersion white wine volumetric usage used is calculated as with Chinese medicine composition weight 5ml/g, the white wine are that grain is burnt.
6. application as claimed in claim 4, it is characterised in that step(1)Middle white wine is that 53 ° of grains are burnt.
7. application as claimed in claim 4, it is characterised in that step(2)Described in filter residue and lees of yellow wine weight ratio be 1:8, The lees of yellow wine is that grain burns the ripe vinasse after single flash.
8. application as claimed in claim 4, it is characterised in that step(2)Described in pectase quality addition with fermentation substrate Weight is calculated as 1%, and the cellulase quality addition is calculated as 1.5% with fermentation substrate weight.
9. application as claimed in claim 4, it is characterised in that step(2)Described in head mold quality addition with fermentation substrate weight Amount is calculated as 0.8%, the wheat koji quality addition and is calculated as 1.8%, the distiller's yeast quality addition with fermentation substrate weight to ferment Matrix weight is calculated as 3.0%.
10. application as claimed in claim 4, it is characterised in that step(3)Middle filtering is will to distill wine liquid to mix with immersion wine liquid It after conjunction, is filtered by vacuum using 0.45 μm of organic microfiltration membranes of micropore, filtrate is sargassum fusifome nutritious lotus seed wine.
CN201510368801.8A 2015-06-26 2015-06-26 A kind of Chinese medicine composition and its application in preparing sargassum fusifome nutritious lotus seed wine Active CN104971295B (en)

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