CN104971209A - Externally used agent for treating tinea pedis and preparation method thereof - Google Patents
Externally used agent for treating tinea pedis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an externally used agent for treating tinea pedis and a preparation method thereof. The agent is prepared from the following main active pharmaceutical ingredients in parts by weight: 9-15 parts of morinda root, 11-16 parts of garden euphorbia herb, 8-17 parts of herb of white loosestrife, 9-12 parts of mountain dragon, 7-14 parts of falsehellebore root and rhizome, 6-12 parts of seed-coat of broadbean, 9-13 parts of twig and leaf of orangeeye butterflybush, 8-12 parts of root of redfruit actionodaphne, 10-16 parts of castor leaf, 9-17 parts of common achyranthes herb, 7-15 parts of fortune eupatorium herb,11-17 parts of leaf of betel pepper, 9-14 parts of roylean euphorbia and 11-18 parts of lily. The agent has the good effects of no trauma, no pain, no toxic or side effect, treatment of both symptoms and root causes, high cure rate, low possibility of relapse after cure and low treatment cost.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of external preparation for the treatment of tinea pedis and preparation method thereof.
Background technology
Tinea pedis system fungal infection causes, and its skin lesion is first one-sided (i.e. single foot) generation often, just infects to offside after several weeks or several months.Vesicle mainly appears at toe abdomen and toe side, and be most commonly between three or four toes, vola also can occur, for dark in property phlysis, can be fused into bulla gradually.The skin lesion of tinea pedis has a feature, i.e. clear border, can gradually to external expansion.Because of PD or scratch, erosion, sepage can be there is, even bacteriological infection, occur pustule etc.Tinea pedis is the foot dermatosis caused by pathogenic fungus, has infectiousness.Tinea pedis is widely popular in the whole world, more general in subtropical and tropical zones.In China, the sickness rate of tinea pedis is also quite high.Do not have sebaceous gland between the vola of people and toe, thus lack the fatty acid suppressing skin filamentous fungi, physiological defense function is poor, and the sweat gland of skin at these positions is very abundant, perspire many, poor, the locally damp warm of air circulation, is conducive to the growth of filamentous fungi in addition.In addition, vola area skin horny layer is thicker, and the keratin in horny layer is the abundant nutrition material of fungus, is conducive to the growth of fungus.Women is at pregnancy duration, and due to endocrine change, the ability causing skin to resist fungal infection declines, and easily suffers from tinea pedis.Overweight people is because of moist between toe, and perspiration dipping easily suffers from tinea pedis.Pedal skin is by wound, and destroying the defense function of skin, is also one of factor of bringing out tinea pedis.Diabetics causes substance metabolism disorderly owing to lacking insulin, and the increase of skin sugar content causes resistance to decline, and also easily suffers from tinea pedis.Abuse of antibiotics, life-time service corticosteroid hormone and immunosuppressant etc., make skin normal flora lack of proper care, also can increase the susceptibility of tinea pedis.The morbidity of tinea pedis is also relevant with living habit.Some people does not note the situation of foot sanitation and hygiene and footgear, for fungus provides good breeding site.
Clinical manifestation is play vesicle, decortication or skin whitening between toe to wet soft, and also can occur erosion or pachyderma, coarse, cracking, and can spread to the sufficient sole of the foot and edge, play is itched.Can accompany local suppuration, red and swollen, pain, inguinal lymphadenopathy, even forms the secondary infection such as shank erysipelas and cellulitis.Due to the place that scratches with hands, often infect, to hands, the tinea manuum (fungal infection of hand and foot) occurs.Fungus grows in finger (toe) first, then become tinea unguium (tinea unguium).Fungus likes the environment of damp warm, and summer, sky overabundant heat antiperspirant, wore rubber overshoes, nylon sock person especially for fungus provides hotbed; The many improvements of the state of an illness in winter, show as skin cracks.There is following several types: 1. vesicle: mostly occur in summer, show as between toe, grain of rice size appears in sufficient edge, vola, dark in property vesicle, evacuate or distribute in groups, bleb wall is thicker, content is limpid, not easily break, mutually merge and form kerionic vesicle, tear bleb wall off, visible honeycomb substrate and the rotten to the corn face of cerise, violent pruritus.2. erosive type: show as local horny layer of epidermis and macerate and turn white.Constantly rub during owing to walking about exfoliation, exposes the rotten to the corn face of cerise; Between severe patient toe seam, toe abdomen and vola intersection skin all can involve, acute pruritus, is mainly between the 3rd, 4,5 toes stitch.Be common in hyperhidrosis person.3. squama keratinization type: symptom is the sufficient sole of the foot, sufficient edge, heel portion skin toe thicken, coarse, desquamation, and squama slabbing or little point-like, come off repeatedly.
Treatment: 1. have erosion between toe, sepage person cannot the strong medicine of external zest, preferably first makes wound surface convergence drying medication again.Can use the soak of 1:8000 potassium permanganate solution, then external-use oil preparation or powder, use the cream such as terbinafine HCl or ointment instead after xerosis cutis.2. if Keratoderma thickens seriously, antifungal drug is difficult to osmotic absorption, first can make cutin softening with 10% unguentum acidi salicylici or whitfield ointment etc., then use antifungal agent.The obvious person of chapped skin, can warm water soaking at every turn, makes cutin softening, then uses antifungal agent.The obvious person of chapped skin, can local anoint after warm water soaking at every turn, then uses plastic sheeting package, twines binder outward, remove, and then use antifungal agent after 24 ~ 48 hours.3. foot plays phlysis, non-ulceration person, first can soak by 3% boric acid solution, then select the antifungal cream such as Bifonazole cream.4. tinea pedis merges bacteriological infection, in principle should first local bacterial-infection resisting, can with furacilin solution or the soak of 1:2000 berberine solution, severe infections person, can oral antibiotic, as cefalexin capsule, erythromycin etc.5. whole body therapeutic.For the tinea pedis of stubbornness, when there is no contraindication, oral medicine can be given.As terbinafine, itraconazole, fluconazol etc.These oral drugs are effective, but should note its side reaction that may bring, and hepatic disfunction person avoids use.6. medication will be adhered to.Tinea pedis is a kind of chronic infection, growth and breeding in fungi autoeciousness horny layer, needs long-term prescription thoroughly to remove.Therefore, after the remission of tinea pedis, still need to adhere to medication, the metabolism cycle of skin is about 28 days, and administration time must adhere to more than surrounding.Preferably carry out Fungus examination and cultivation, continuous three weeks are all that feminine gender just calculates healing.7. do not abuse medicine.Tinea pedis medication is it is crucial that should carry out coherent regular treatment according to typing.8. medication will according to the concrete condition of pathological changes.Ulceration place can not use tincture, and skin is thickening, and breach should use ointment.9., during tinea pedis generation secondary infection, local occurs that acute inflammation just by general tinea pedis treating, first can not should process secondary infection.If any redness, local can external boric acid water or nitrofural liquid cooling temperature deposited, also want whole body application antibiotic if desired, and suitably have a rest according to doctor ordered.
Application publication number CN 103705585 A(application number 201310678500.6) Chinese patent literature disclose a kind of Chinese medicine for the treatment of tinea pedis, it is characterized in that crude drug is according to the mass fraction: Radix Sophorae Flavescentis 25-35 part, Alumen 25-35 part, Herba Senecionis Scandentis 15-25 part, Fructus Kochiae 20-25 part, Fructus Cnidii 25-35 part, dried Alumen 15-30 part, Galla Chinensis 15-25 part.Application publication number CN 104147434 A(application number 201410333708.9) Chinese patent literature disclose a kind of Chinese medicine lotion for the treatment of tinea pedis, described Chinese medicine lotion is prepared by the following method: get Herba speranskiae tuberculatae 20-30 part, Semen Coicis 20-30 part, Bulbus Allii 5-10 part, Cortex Magnoliae Officinalis 30-40 part, Folium Artemisiae Argyi 30-40 part, Folium Eriobotryae 30-40 part, Radix Sophorae Flavescentis 20-30 part, Herba Patriniae 20-30 part, Herba Taraxaci 10-20 part, Radix Scutellariae 10-20 part, Pericarpium Citri Reticulatae Viride 10-20 part by weight, decoct and get final product.Application publication number CN 104288632 A(application number 201410471574.7) Chinese patent literature disclose a kind of pharmaceutical preparation being used for the treatment of Cornification Excess Type Tinea Pedis, its crude drug comprises Spina Gleditsiae, Rhizoma Ligustici, Herba Pogostemonis, Fructus Xanthii, Caulis Polygoni Multiflori, the Radix Angelicae Dahuricae, Folium Viticis Negundo, Bulbus Allii, Cortex Meliae, Radix Sophorae Flavescentis, Rhizoma Smilacis Chinensis, Rhizoma Polygonati, Herba Chelidonii, Cortex Dictamni, Folium Artemisiae Argyi, Radix Sophorae Tonkinensis, Aloe, Fructus Toosendan, Cortex Pseudolaricis, the Radix Stemonae, the Fructus Kochiae, Radix Ranunculi Ternati, Radix Clematidis and Flos Chrysanthemi.
At present, the types of drugs of market being treated tinea pedis is various, but it is low mostly to there is effective percentage, and relapse rate is high, and side effect is large, the shortcomings such as price is more expensive.Therefore, develop a kind of economy, the medicine for the treatment of tinea pedis evident in efficacy is necessary.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of external preparation for the treatment of tinea pedis and preparation method thereof.Hurtless measure of the present invention, no pain, have no side effect, treating both the principal and secondary aspects of a disease, cure rate is high, not easily recurs more, low in treatment cost.
Technical scheme of the present invention is:
The external preparation for the treatment of tinea pedis, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Morindae Officinalis 9-15, Herba Euphoubiae Hirtae 11-16, Herba Lysimachiae Candidae 8-17, Caulis Arcangelisiae 9-12, Rhizoma et radix veratri (Radix Rhizoma Veratri) 7-14, Testa Viciae fabae 6-12, Ramulus et folium buddlejae davidii 9-13, Radix Actinodaphnes Cupularis 8-12, Folium Ricini 10-16, Radix achyranthis asperae (Herba Achyranthis Asperae) 9-17, Herba Eupatorii 7-15 ， Folium piperis betlis 11-17, Euphorbia royleana Boiss. 9-14, Bulbus Lilii 11-18.
The external preparation for the treatment of tinea pedis, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Morindae Officinalis 11-13, Herba Euphoubiae Hirtae 12-14, Herba Lysimachiae Candidae 10-15, Caulis Arcangelisiae 10-11, Rhizoma et radix veratri (Radix Rhizoma Veratri) 9-13, Testa Viciae fabae 8-11, Ramulus et folium buddlejae davidii 10-12, Radix Actinodaphnes Cupularis 9-11, Folium Ricini 12-14, Radix achyranthis asperae (Herba Achyranthis Asperae) 11-15, Herba Eupatorii 10-13 Folium piperis betlis 12-15, Euphorbia royleana Boiss. 11-13, Bulbus Lilii 12-16.
The external preparation for the treatment of tinea pedis, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Morindae Officinalis 12, Herba Euphoubiae Hirtae 13, Herba Lysimachiae Candidae 13, Caulis Arcangelisiae 10.5, Rhizoma et radix veratri (Radix Rhizoma Veratri) 11, Testa Viciae fabae 9, Ramulus et folium buddlejae davidii 11, Radix Actinodaphnes Cupularis 10, Folium Ricini 13, Radix achyranthis asperae (Herba Achyranthis Asperae) 12, Herba Eupatorii 12 Folium piperis betlis 14, Euphorbia royleana Boiss. 12, Bulbus Lilii 15.
The preparation method of the external preparation of above-mentioned treatment tinea pedis is:
(1) Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Folium Ricini and Euphorbia royleana Boiss. are put into pot, add 6.8-8.4 times of water gaging, first decoct with high heat, fire of larding speech with literary allusions after boiling boils 32-46 minute, leaches medicinal liquid, and being condensed into relative density at 60 DEG C is the ointment of 1.27-1.32;
(2) Ramulus et folium buddlejae davidii is put into boiling water, add a cover, soak to pull out after 3-5 hour and drain, then dry, be ground into fine powder, cross 150 mesh sieves;
(3) 8 taste crude drug except Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Ramulus et folium buddlejae davidii, Folium Ricini and Euphorbia royleana Boiss. are ground to the powder altogether, cross 150 mesh sieves;
(4) step (1), step (2) and step (3) are mixed, add the vaseline of step (1), step (2) and step (3) gained gross weight 1/5-3/5, mix well, to obtain final product.
Preferably be, in step (1), to add 7.5-8.2 times of water gaging.
Preferably be that, in step (1), fire of larding speech with literary allusions after boiling boils 35-42 minute.
Preferably be in step (1), being condensed into relative density at 60 DEG C is the ointment of 1.29-1.31.
Preferably be in step (2), soak to pull out after 3.2-4.6 hour and drain.
Preferably be in step (4), add the vaseline of step (1), step (2) and step (3) gained gross weight 1/4-1/2.
Be more preferably, in step (1), add 7.8 times of water gagings.
Be more preferably, fire of larding speech with literary allusions after boiling in step (1) boils 37 minutes.
Be more preferably, being condensed into relative density at 60 DEG C in step (1) is the ointment of 1.3.
Be more preferably, in step (2), immersion is pulled out after 3.8 hours and is drained.
Be more preferably, in step (4), add the vaseline of step (1), step (2) and step (3) gained gross weight 1/3.
The external preparation scientific formula for the treatment of tinea pedis provided by the invention is reasonable.In addition, excellent results of the present invention also shows:
1, hurtless measure, no pain, have no side effect;
2, there is effect of dampness removing to stop itchin, heat-clearing and toxic substances removing, expelling wind and removing dampness, killing parasites for relieving itching, eliminating fire and detoxication, reducing swelling and alleviating pain,
Finally reach the object of curing tinea pedis;
3, treating both the principal and secondary aspects of a disease, cure rate is high, not easily recurs more;
4, low in treatment cost;
5, preparation method is simple;
6, easy to use, do not affect living and studying.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the external preparation for the treatment of tinea pedis, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): Radix Morindae Officinalis 9 parts, Herba Euphoubiae Hirtae 11 parts, Herba Lysimachiae Candidae 8 parts, Caulis Arcangelisiae 9 parts, Rhizoma et radix veratri (Radix Rhizoma Veratri) 7 parts, Testa Viciae fabae 6 parts, Ramulus et folium buddlejae davidii 9 parts, Radix Actinodaphnes Cupularis 8 parts, Folium Ricini 10 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 9 parts, Herba Eupatorii 7 Fen ， Folium piperis betlis 11 parts, Euphorbia royleana Boiss. 9 parts, Bulbus Lilii 11 parts.
The preparation method of the external preparation of above-mentioned treatment tinea pedis is:
(1) Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Folium Ricini and Euphorbia royleana Boiss. are put into pot, add 6.8 times of water gagings, first decoct with high heat, fire of larding speech with literary allusions after boiling boils 32 minutes, leaches medicinal liquid, and being condensed into relative density at 60 DEG C is the ointment of 1.27;
(2) Ramulus et folium buddlejae davidii is put into boiling water, add a cover, soak to pull out after 3 hours and drain, then dry, be ground into fine powder, cross 150 mesh sieves;
(3) 8 taste crude drug except Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Ramulus et folium buddlejae davidii, Folium Ricini and Euphorbia royleana Boiss. are ground to the powder altogether, cross 150 mesh sieves;
(4) step (1), step (2) and step (3) are mixed, add the vaseline of step (1), step (2) and step (3) gained gross weight 1/5, mix well, to obtain final product.
The using method of the external preparation of gained treatment tinea pedis of the present invention is: external, gets products obtained therefrom of the present invention and is applied to affected part, every day twice sooner or later.
embodiment 2the external preparation for the treatment of tinea pedis, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): Radix Morindae Officinalis 15 parts, Herba Euphoubiae Hirtae 16 parts, Herba Lysimachiae Candidae 17 parts, Caulis Arcangelisiae 12 parts, Rhizoma et radix veratri (Radix Rhizoma Veratri) 14 parts, Testa Viciae fabae 12 parts, Ramulus et folium buddlejae davidii 13 parts, Radix Actinodaphnes Cupularis 12 parts, Folium Ricini 16 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 17 parts, Herba Eupatorii 15 Fen ， Folium piperis betlis 17 parts, Euphorbia royleana Boiss. 14 parts, Bulbus Lilii 18 parts.
The preparation method of the external preparation of above-mentioned treatment tinea pedis is:
(1) Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Folium Ricini and Euphorbia royleana Boiss. are put into pot, add 8.4 times of water gagings, first decoct with high heat, fire of larding speech with literary allusions after boiling boils 46 minutes, leaches medicinal liquid, and being condensed into relative density at 60 DEG C is the ointment of 1.32;
(2) Ramulus et folium buddlejae davidii is put into boiling water, add a cover, soak to pull out after 5 hours and drain, then dry, be ground into fine powder, cross 150 mesh sieves;
(3) 8 taste crude drug except Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Ramulus et folium buddlejae davidii, Folium Ricini and Euphorbia royleana Boiss. are ground to the powder altogether, cross 150 mesh sieves;
(4) step (1), step (2) and step (3) are mixed, add the vaseline of step (1), step (2) and step (3) gained gross weight 3/5, mix well, to obtain final product.
model case one:high XX, man, 36 years old.Main suit: suffer from tinea pedis more than 2 years.Patient suffers from tinea pedis 2 years, during this period, once attempts the treatment of multiple method, and all fails to cure.On April 13rd, 2009 examines.Swell and ache between patient's right foot two toe, three-toed, instep edema.Water juice is had to go out between left foot two toe, three-toed, pruritus pain.Be diagnosed as tinea pedis.Use the external preparation of the present embodiment gained treatment tinea pedis, get the present embodiment products obtained therefrom and be applied to affected part, every day twice sooner or later.Treat 3 days, remission.Treat after 6 days, all transference cures, recovery from illness.Follow up a case by regular visits to and do not recur.
embodiment 3the external preparation for the treatment of tinea pedis, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): Radix Morindae Officinalis 11 parts, Herba Euphoubiae Hirtae 12 parts, Herba Lysimachiae Candidae 10 parts, Caulis Arcangelisiae 10 parts, Rhizoma et radix veratri (Radix Rhizoma Veratri) 9 parts, Testa Viciae fabae 8 parts, Ramulus et folium buddlejae davidii 10 parts, Radix Actinodaphnes Cupularis 9 parts, Folium Ricini 12 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 11 parts, Herba Eupatorii 10 Fen ， Folium piperis betlis 12 parts, Euphorbia royleana Boiss. 11 parts, Bulbus Lilii 12 parts.
The preparation method of the external preparation of above-mentioned treatment tinea pedis is:
(1) Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Folium Ricini and Euphorbia royleana Boiss. are put into pot, add 7.5 times of water gagings, first decoct with high heat, fire of larding speech with literary allusions after boiling boils 35 minutes, leaches medicinal liquid, and being condensed into relative density at 60 DEG C is the ointment of 1.29;
(2) Ramulus et folium buddlejae davidii is put into boiling water, add a cover, soak to pull out after 3.2 hours and drain, then dry, be ground into fine powder, cross 150 mesh sieves;
(3) 8 taste crude drug except Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Ramulus et folium buddlejae davidii, Folium Ricini and Euphorbia royleana Boiss. are ground to the powder altogether, cross 150 mesh sieves;
(4) step (1), step (2) and step (3) are mixed, add the vaseline of step (1), step (2) and step (3) gained gross weight 1/4, mix well, to obtain final product.
model case two:old XX, man, 42 years old.Main suit: suffer from tinea pedis more than 5 years.Once multi-medicament treatment was used, poor effect.On April 16th, 2009 examines.Examine and see patient's biped toe, sole pruritus, toe vesicle is peeled, biped with and biped hind paw pachyderma, coarse chapping be mingled with squama keratinization.Use the external preparation of the present embodiment gained treatment tinea pedis, get the present embodiment products obtained therefrom and be applied to affected part, every day twice sooner or later.Treat 5 days, symptom obviously alleviates.Continue use 5 days, all diseases entirely disappear and fully recover.Follow up a case by regular visits to and do not recur so far.
embodiment 4the external preparation for the treatment of tinea pedis, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): Radix Morindae Officinalis 13 parts, Herba Euphoubiae Hirtae 14 parts, Herba Lysimachiae Candidae 15 parts, Caulis Arcangelisiae 11 parts, Rhizoma et radix veratri (Radix Rhizoma Veratri) 13 parts, Testa Viciae fabae 11 parts, Ramulus et folium buddlejae davidii 12 parts, Radix Actinodaphnes Cupularis 11 parts, Folium Ricini 14 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 15 parts, Herba Eupatorii 13 Fen ， Folium piperis betlis 15 parts, Euphorbia royleana Boiss. 13 parts, Bulbus Lilii 16 parts.
The preparation method of the external preparation of above-mentioned treatment tinea pedis is:
(1) Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Folium Ricini and Euphorbia royleana Boiss. are put into pot, add 8.2 times of water gagings, first decoct with high heat, fire of larding speech with literary allusions after boiling boils 42 minutes, leaches medicinal liquid, and being condensed into relative density at 60 DEG C is the ointment of 1.31;
(2) Ramulus et folium buddlejae davidii is put into boiling water, add a cover, soak to pull out after 4.6 hours and drain, then dry, be ground into fine powder, cross 150 mesh sieves;
(3) 8 taste crude drug except Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Ramulus et folium buddlejae davidii, Folium Ricini and Euphorbia royleana Boiss. are ground to the powder altogether, cross 150 mesh sieves;
(4) step (1), step (2) and step (3) are mixed, add the vaseline of step (1), step (2) and step (3) gained gross weight 1/2, mix well, to obtain final product.
model case three:grandson XX, female, 28 years old.Main suit: suffer from tinea pedis more than 4 years.Before 4 years, patient is found suffers from tinea pedis.Over 4 years, patient once attempted the method for multiple treatment tinea pedis, and therapeutic effect is not good.On June 8th, 2008 examines.Between patient's both feet the 5th and four toes, there is the red phlysis be dispersed between the 3rd and two toes, rotten to the corn flowing water, pruritus pain, red tongue, tongue fur BOHUANG, slippery and rapid pulse.Be diagnosed as tinea pedis.Use the external preparation of the present embodiment gained treatment tinea pedis, get the present embodiment products obtained therefrom and be applied to affected part, every day twice sooner or later.Treat 3 days, symptom alleviates.Continue use one week, all diseases disappear entirely.Follow up a case by regular visits to and do not recur so far.
embodiment 5the external preparation for the treatment of tinea pedis, the primary raw material medicine getting following weight parts is prepared from (every part is 700g): Radix Morindae Officinalis 12 parts, Herba Euphoubiae Hirtae 13 parts, Herba Lysimachiae Candidae 13 parts, Caulis Arcangelisiae 10.5 parts, Rhizoma et radix veratri (Radix Rhizoma Veratri) 11 parts, Testa Viciae fabae 9 parts, Ramulus et folium buddlejae davidii 11 parts, Radix Actinodaphnes Cupularis 10 parts, Folium Ricini 13 parts, Radix achyranthis asperae (Herba Achyranthis Asperae) 12 parts, Herba Eupatorii 12 Fen ， Folium piperis betlis 14 parts, Euphorbia royleana Boiss. 12 parts, Bulbus Lilii 15 parts.
The preparation method of the external preparation of above-mentioned treatment tinea pedis is:
(1) Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Folium Ricini and Euphorbia royleana Boiss. are put into pot, add 7.8 times of water gagings, first decoct with high heat, fire of larding speech with literary allusions after boiling boils 37 minutes, leaches medicinal liquid, and being condensed into relative density at 60 DEG C is the ointment of 1.3;
(2) Ramulus et folium buddlejae davidii is put into boiling water, add a cover, soak to pull out after 3.8 hours and drain, then dry, be ground into fine powder, cross 150 mesh sieves;
(3) 8 taste crude drug except Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Ramulus et folium buddlejae davidii, Folium Ricini and Euphorbia royleana Boiss. are ground to the powder altogether, cross 150 mesh sieves;
(4) step (1), step (2) and step (3) are mixed, add the vaseline of step (1), step (2) and step (3) gained gross weight 1/3, mix well, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Morindae Officinalis: base is former: be the root of dicotyledon medicine Maguireothamnus speciosus Radix Morindae Officinalis.The property of medicine: acrid, sweet, warm.Return liver, kidney channel.Function cures mainly: reinforcing the kidney and supporting YANG, bone and muscle strengthening, expelling wind and removing dampness.For impotence due to deficiency of the kidney, seminal emission premature ejaculation, few abdomen cold type of pain, incontinence of urine, cold womb is infertile, anemofrigid-damp arthralgia, soreness of the waist and knees, rheumatism limb gas.
Herba Euphoubiae Hirtae: base is former: be the whole herb with root of euphorbia plant Ramulus et Folium Bauhiniae Faberi.The property of medicine: pungent; Acid; Frightened; Mild toxicity.Return lung, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing; Dampness removing is antipruritic; Lactogenesis.Main lung abscess; Acute mastitis; Dysentery; Have loose bowels; Pyretic stranguria; Hematuria; Eczema; Tinea pedis; Skin pruritus; Furuncle swelling toxin; Ulcerative gingivitis; Puerperal lactation deficiency.
Herba Lysimachiae Candidae: base is former: be the herb of Ofthe Primulaceae pool Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).The property of medicine: bitter, cool.Function cures mainly: heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Inducing diuresis and reducing edema.Cure mainly laryngopharynx swelling and pain, carbuncle sore tumefacting virus, acute mastitis, venom, injury and bone fracture, rheumatic arthralgia, beriberi edema, paddy field dermatitis.
Caulis Arcangelisiae: base is former: be root or the ratan of menispermaceous plants Caulis Arcangelisiae.The property of medicine: bitter; Cold; Mild toxicity.GUIXIN, lung, large intestine channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Eliminating fire and detoxication.Main intestinal is scorching; Bacillary dysentery; Jaundice; Malaria; Furuncle and phyma; Eczema; Vaginitis; Bronchitis; Pertussis; Tonsillitis; Eye conjunctivitis.
Rhizoma et radix veratri (Radix Rhizoma Veratri): base is former: be the root and rhizome of liliaceous plant Rhizoma et radix veratri (Radix Rhizoma Veratri), bull ridge Rhizoma et radix veratri (Radix Rhizoma Veratri), hair fringe Rhizoma et radix veratri (Radix Rhizoma Veratri), Xingan Rhizoma et radix veratri (Radix Rhizoma Veratri) and hair leaf Rhizoma et radix veratri (Radix Rhizoma Veratri).The property of medicine: bitter; Pungent; Cold; Poisonous.Return lung, stomach, Liver Channel.Function cures mainly: gush leaf wind-phlegm; Parasite killing.In master, wind-phlegm is stopped up; Epilepsy; Malaria; Scabies; Malignant boil.
Testa Viciae fabae: base is former: be the seed coat of the vetch plant Semen Viciae fabae of pulse family.The property of medicine: sweet, light, flat.Function cures mainly: promoting diuresis to eliminate damp pathogen, hemostasis, removing toxic substances.Cure mainly edema, beriberi, dysuria, spit blood, vaginal bleeding during pregnancy, hematochezia, epidemic blisters, impetigo, scrofula.
Ramulus et folium buddlejae davidii: base is former: be branch and leaf, the root bark of Buddlejaceae plant Buddleia davidii.The property of medicine: pungent, micro-hardship, warm in nature, poisonous.GUIXIN, liver, kidney channel.Function cures mainly: expelling wind and cold; Promoting blood circulation and stopping pain; Removing toxic substances parasite killing.Main cough due to wind and cold; Arthralgia pain; Traumatic injury; Carbuncle furuncle; Women's pudendal pruritus; Leprosy; Tinea pedis.
Radix Actinodaphnes Cupularis: base is former: be root or the leaf of the yellow meat nanmu of canella Fructus Pyracanthae.The property of medicine: pungent; Property is put down.Return lung meridian.Function cures mainly: clearing heat for detumescence; Stopping nausea and vomiting by lowering the adverse flow of QI.Main burn due to hot liquid or fire; Tinea pedis; Hemorrhoid; Nausea and vomiting.
Folium Ricini: base is former: be the leaf of euphorbia plant Semen Ricini.The property of medicine: bitter in the mouth; Pungent; Property is put down; Mild toxicity.Function cures mainly: expelling wind and removing dampness; To draw out pus by applying a plaster to the affected part detumescence.Main foot gas; Rheumatic arthralgia; Carbuncle pyogenic infections from tumour or sore; Scabies pruritus; Uterine prolapse; Proctoptosis; Chant phlegm dyspnea of coughing.
Radix achyranthis asperae (Herba Achyranthis Asperae): base is former: be the herb of amaranthaceous plant coarse wool Radix Achyranthis Bidentatae.The property of medicine: bitter; Acid; Cold nature.Return liver, lung, urinary bladder channel.Function cures mainly: blood circulation promoting and blood stasis dispelling; Inducing diuresis for treating stranguria syndrome; Clearing away heat and expelling pathogen in the exterior.Main warp closes; Dysmenorrhea; Menoxenia; Traumatic injury; Rheumatic arthritis; Gonorrhea; Edema; Damp-heat vaginal discharge, fever caused by exogenous pathogens; Malaria; Pharyngalgia; Furuncle carbuncle.
Herba Eupatorii: base is former: be the stem and leaf of feverfew Herba Chlorophyti.Chemical composition: Herba Chlorophyti herb containing volatile oil 1.5 ~ 2%, contains in oil: cymol neryl acetate and 5-methyl thymol ether, the above two infected by influenzas have direct repression.Leaf contains coumarin, o-coumaric acid and thymohydroquinone.The property of medicine: pungent, flat.Enter spleen, stomach warp.Function cures mainly: clearing away summer-heat, wards off dirty, removing dampness, regulating menstruation.Control and experience heat-damp in summer, cold and heat are had a headache, and accumulate in damp, gastral cavity painful abdominal mass is not hungry, sweet taste in the mouth greasy fur, menoxenia.
Folium piperis betlis: base is former: be the leaf of Piperaceae Zhi Wu Spica piperis betlis.The property of medicine: pungent; Temperature.Attach to the lung and stomach meridians.Function cures mainly: expelling wind and cold, promoting the circulation of QI and reducing phlegm, removing toxic substances and promoting subsidence of swelling, dampness removing to stop itchin.Main cough due to wind and cold, asthma, pertussis, institute's abdominal distention and pain, dyspepsia is indigestion and loss of appetite, edema, and traumatic injury wound is swollen, and rheumatic ostalgia, sore swollen toxin, swelling and pain of hemorrhoid, burn, pathogenic wind-toxic beriberi, mange, eczema epidemic disease is itched.
Euphorbia royleana Boiss.: base is former: be the Herb of euphorbia plant Euphorbia royleana Boiss..The property of medicine: pained; Flat; Poisonous.GUIXIN, spleen channel.Function cures mainly: removing toxic substances of dispeling the wind; Killing parasites for relieving itching.Main sore swollen toxin; Psoriasis.
Bulbus Lilii: base is former: be the dry meat scale leaf of liliaceous plant tiger lily, Bulbus Lilii or Lilium tenuifolium.The property of medicine: sweet, cold.GUIXIN, lung meridian.Function cures mainly: nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.
test example 1the clinical practice of the external preparation (embodiment 5) of gained of the present invention treatment tinea pedis: in June ,-2009 in May, 2007, screen 260 routine tinea pedis patients in 3 hospitals, wherein male 140 example, women 120 example, age 19-62 year, 40.8 years old mean age.Be divided into two groups at random, experimental group and matched group (often organizing 130 examples).Between two groups of patients, the aspect such as sex, age, the state of an illness and course of disease compares, and no significant difference (P > 0.05), has comparability.
Therapeutic Method: experimental group uses gained of the present invention to treat the external preparation of tinea pedis, and using method is: external, gets products obtained therefrom of the present invention and is applied to affected part, every day twice sooner or later 5 days is a course for the treatment of.Matched group uses the medicine of conventional therapy tinea pedis (as clean in Corallium Japonicum Kishinouye tinea, Compound Ketoconazole Cream, Pevisone emulsifiable paste etc.), within 5 days, is a course for the treatment of.Comparitive study is carried out after two groups of patients all treat two courses for the treatment of.
Curative effect situation criterion: recovery from illness: clinical symptoms all disappears, skin lesion is fully recovered; Take a turn for the better: clinical symptoms obviously alleviates, skin lesion recovers; Invalid: symptom and skin lesion are all not improved.Total effectively comprising fully recovers and takes a turn for the better, and result is as shown in table 1.
Table 1: the external preparation compliance test result of gained treatment tinea pedis of the present invention
Efficacy analysis: after two groups of cases treat two courses for the treatment of, experimental group recovery from illness 106 example, take a turn for the better 22 examples, invalid 2 examples, total effective rate 98.46%; Matched group recovery from illness 62 example, take a turn for the better 40 examples, invalid 28 examples, total effective rate 78.46%.The cure rate of experimental group and total effective rate are apparently higher than matched group.Test shows, the clinical efficacy of experimental group is obviously better than matched group, and significant difference (P < 0.05), has statistical significance.
The present invention is primary raw material medicine with Radix Morindae Officinalis, Herba Euphoubiae Hirtae, Herba Lysimachiae Candidae and Caulis Arcangelisiae etc., makes the external preparation for the treatment of tinea pedis.Radix Morindae Officinalis reinforcing the kidney and supporting YANG in side, bone and muscle strengthening, expelling wind and removing dampness.Herba Euphoubiae Hirtae heat-clearing and toxic substances removing; Dampness removing is antipruritic; Lactogenesis.Herba Lysimachiae Candidae heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Inducing diuresis and reducing edema.Caulis Arcangelisiae clearing away heat-damp and promoting diuresis; Eliminating fire and detoxication.Rhizoma et radix veratri (Radix Rhizoma Veratri) gushes leaf wind-phlegm; Parasite killing.Testa Viciae fabae promoting diuresis to eliminate damp pathogen, hemostasis, removing toxic substances.Ramulus et folium buddlejae davidii expelling wind and cold; Promoting blood circulation and stopping pain; Removing toxic substances parasite killing.Radix Actinodaphnes Cupularis clearing heat for detumescence; Stopping nausea and vomiting by lowering the adverse flow of QI.Folium Ricini expelling wind and removing dampness; To draw out pus by applying a plaster to the affected part detumescence.Radix achyranthis asperae (Herba Achyranthis Asperae) blood circulation promoting and blood stasis dispelling; Inducing diuresis for treating stranguria syndrome; Clearing away heat and expelling pathogen in the exterior.Herba Eupatorii clearing away summer-heat, wards off dirty, removing dampness, regulating menstruation.Folium piperis betlis expelling wind and cold, promoting the circulation of QI and reducing phlegm, removing toxic substances and promoting subsidence of swelling, dampness removing to stop itchin.Euphorbia royleana Boiss. dispels the wind removing toxic substances; Killing parasites for relieving itching.Bulbus Lilii nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.All medicines share, and play effect of dampness removing to stop itchin, heat-clearing and toxic substances removing, expelling wind and removing dampness, killing parasites for relieving itching, eliminating fire and detoxication, reducing swelling and alleviating pain altogether, finally reach the object of curing tinea pedis.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. treat the external preparation of tinea pedis, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Morindae Officinalis 9-15, Herba Euphoubiae Hirtae 11-16, Herba Lysimachiae Candidae 8-17, Caulis Arcangelisiae 9-12, Rhizoma et radix veratri (Radix Rhizoma Veratri) 7-14, Testa Viciae fabae 6-12, Ramulus et folium buddlejae davidii 9-13, Radix Actinodaphnes Cupularis 8-12, Folium Ricini 10-16, Radix achyranthis asperae (Herba Achyranthis Asperae) 9-17, Herba Eupatorii 7-15 Folium piperis betlis 11-17, Euphorbia royleana Boiss. 9-14, Bulbus Lilii 11-18.
2. the external preparation for the treatment of tinea pedis as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Morindae Officinalis 11-13, Herba Euphoubiae Hirtae 12-14, Herba Lysimachiae Candidae 10-15, Caulis Arcangelisiae 10-11, Rhizoma et radix veratri (Radix Rhizoma Veratri) 9-13, Testa Viciae fabae 8-11, Ramulus et folium buddlejae davidii 10-12, Radix Actinodaphnes Cupularis 9-11, Folium Ricini 12-14, Radix achyranthis asperae (Herba Achyranthis Asperae) 11-15, Herba Eupatorii 10-13 Folium piperis betlis 12-15, Euphorbia royleana Boiss. 11-13, Bulbus Lilii 12-16.
3. the external preparation for the treatment of tinea pedis as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Morindae Officinalis 12, Herba Euphoubiae Hirtae 13, Herba Lysimachiae Candidae 13, Caulis Arcangelisiae 10.5, Rhizoma et radix veratri (Radix Rhizoma Veratri) 11, Testa Viciae fabae 9, Ramulus et folium buddlejae davidii 11, Radix Actinodaphnes Cupularis 10, Folium Ricini 13, Radix achyranthis asperae (Herba Achyranthis Asperae) 12, Herba Eupatorii 12 Folium piperis betlis 14, Euphorbia royleana Boiss. 12, Bulbus Lilii 15.
4. the preparation method of the external preparation of the treatment tinea pedis as described in as arbitrary in claims 1 to 3, it is characterized in that, step is as follows:
(1) Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Folium Ricini and Euphorbia royleana Boiss. are put into pot, add 6.8-8.4 times of water gaging, first decoct with high heat, fire of larding speech with literary allusions after boiling boils 32-46 minute, leaches medicinal liquid, and being condensed into relative density at 60 DEG C is the ointment of 1.27-1.32;
(2) Ramulus et folium buddlejae davidii is put into boiling water, add a cover, soak to pull out after 3-5 hour and drain, then dry, be ground into fine powder, cross 150 mesh sieves;
(3) 8 taste crude drug except Herba Euphoubiae Hirtae, Caulis Arcangelisiae, Rhizoma et radix veratri (Radix Rhizoma Veratri), Ramulus et folium buddlejae davidii, Folium Ricini and Euphorbia royleana Boiss. are ground to the powder altogether, cross 150 mesh sieves;
(4) step (1), step (2) and step (3) are mixed, add the vaseline of step (1), step (2) and step (3) gained gross weight 1/5-3/5, mix well, to obtain final product.
5. the preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 4, is characterized in that, add 7.5-8.2 times of water gaging (preferably adding 7.8 times of water gagings) in step (1).
6. the preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 4, it is characterized in that, fire of larding speech with literary allusions after boiling in step (1) boils 35-42 minute (fire of larding speech with literary allusions after preferably boiling boils 37 minutes).
7. the preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 4, is characterized in that, be condensed into the ointment (being preferably condensed into relative density at 60 DEG C is the ointment of 1.3) that relative density at 60 DEG C is 1.29-1.31 in step (1).
8. treat the preparation method of the external preparation of tinea pedis as claimed in claim 4, it is characterized in that, in step (2), immersion is pulled out after 3.2-4.6 hour and is drained (preferably immersion is pulled out after 3.8 hours and drained).
9. the preparation method of the external preparation for the treatment of tinea pedis as claimed in claim 4, it is characterized in that, in step (4), add the vaseline (preferably adding the vaseline of step (1), step (2) and step (3) gained gross weight 1/3) of step (1), step (2) and step (3) gained gross weight 1/4-1/2.
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| CN106215066A (en) * | 2016-09-27 | 2016-12-14 | 杨巧霞 | Treat the Traditional Chinese medicine foot soaping liquid of chronic tinea pedis acute attack stage |
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| WO2013154806A1 (en) * | 2012-04-10 | 2013-10-17 | Van Aller Robert Thomas | Herbal composition and a method of making thereof |
| CN104013851A (en) * | 2014-06-24 | 2014-09-03 | 李文职 | Traditional Chinese medicine (TCM) preparation for treating beriberi |
| CN104352923A (en) * | 2014-11-29 | 2015-02-18 | 顾明明 | Traditional Chinese medicine liquid for treating dermatophytosis and preparation method |
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| WO2013154806A1 (en) * | 2012-04-10 | 2013-10-17 | Van Aller Robert Thomas | Herbal composition and a method of making thereof |
| CN104013851A (en) * | 2014-06-24 | 2014-09-03 | 李文职 | Traditional Chinese medicine (TCM) preparation for treating beriberi |
| CN104352923A (en) * | 2014-11-29 | 2015-02-18 | 顾明明 | Traditional Chinese medicine liquid for treating dermatophytosis and preparation method |
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| CN106215066A (en) * | 2016-09-27 | 2016-12-14 | 杨巧霞 | Treat the Traditional Chinese medicine foot soaping liquid of chronic tinea pedis acute attack stage |
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