CN104958588B - A kind of composition using miracle fruit leaf as primary raw material and its application as drug or health care product - Google Patents
A kind of composition using miracle fruit leaf as primary raw material and its application as drug or health care product Download PDFInfo
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Abstract
The present invention relates to Chinese medicine compound prescription technical fields, specifically disclose a kind of composition using miracle fruit leaf as primary raw material and its application as drug or health care product.The composition is made of the raw material comprising following component: miracle fruit leaf, wheat herb, Qingqian Willow leaf and dried orange peel.The composition has the effects that good hypoglycemic, reducing blood lipid, liver protecting and weight-reducing, can be used as health care product or drug uses.
Description
Technical field
The present invention relates to Chinese medicine compound prescription technical fields, and in particular to a kind of group using miracle fruit leaf as primary raw material
Close object and its application as drug or health care product.
Background technique
Miracle fruit, Classification system are Synsepalum dulcificum Daniell, are typical heat band evergreen shrubs,
Source area is in West Africa, Ghana, one band of the Congo.In the 1960s, when Premier Zhou Enlai accesses to West Africa,
Republic of Ghana gives premier Zhou using miracle fruit as state's gift.Hereafter, miracle fruit starts to cultivate in China.
Miracle fruit is rounded, long 2 centimetres, 1.2 centimetres wide, fruit ruby when mature, pulp white succulence,
One piece of olive shape of seed, dark brown.Pulp glycoprotein rich in, vitamin C, citric acid, amber in miracle fruit
Amber acid, oxalic acid etc., its magical place are to have eaten miracle fruit half an hour containing a kind of spoiled protease (also known as On Miraculin)
It is interior, other acid fruits are then eaten, can think that these sour water fruits are no longer tart flavour, and become sweet taste, therefore named miracle fruit.
Miracle fruit is mainly sold in the form of fresh fruit or fruit juice at present, and there are no develop miracle fruit at drug or health care
Product.Therefore, miracle fruit is developed to the bigger value that can play miracle fruit at drug or health care product, there is important meaning
Justice.
Summary of the invention
The technical problem to be solved by the present invention is to, in order to overcome in the prior art miracle fruit medicine and health care neck
Underexploitation in domain provides a kind of composition using miracle fruit leaf as primary raw material.
Above-mentioned technical problem to be solved by this invention is achieved by the following technical programs:
A kind of composition using miracle fruit leaf as primary raw material, is made of the raw material comprising following component: miracle fruit leaf,
Wheat herb, Qingqian Willow leaf and dried orange peel.
The present invention is in order to further develop the medicine and health purpose of miracle fruit, mainly for hypertension, hyperlipidemia, liver
The common diseases such as disease, inventor grope to deploy according to theory of traditional Chinese medical science by meticulous research, provide above-mentioned Chinese medicine composition.
The composition has excellent hypoglycemic, reducing blood lipid, liver protecting, antialcoholism action, additionally there is weight-reducing etc. to make
With.
Preferably, the composition is made of the raw material comprising following parts by weight:
10 ~ 15 parts of miracle fruit leaf；10 ~ 15 parts of wheat herb；5 ~ 10 parts of Qingqian Willow leaf；Dried orange peel 1 ~ 3
Part.
It is further preferred that the composition, is made of the raw material comprising following parts by weight:
10 ~ 15 parts of miracle fruit leaf；10 ~ 15 parts of wheat herb；5 parts of Qingqian Willow leaf；1 part of dried orange peel.
Most preferably, the composition is made of the raw material comprising following parts by weight:
10 parts of miracle fruit leaf；10 parts of wheat herb；5 parts of Qingqian Willow leaf；1 part of dried orange peel.
The composition the preparation method comprises the following steps: by miracle fruit leaf, wheat herb, Qingqian Willow leaf and dried orange peel mix after, use
Water extracts, and is drying to obtain after concentration.
Preferably, described the preparation method comprises the following steps: by miracle fruit leaf, wheat herb, Qingqian Willow leaf and dried orange peel mix after, use water
Heating and refluxing extraction is freeze-dried to obtain composition freeze-dried powder after concentration.
Preferably, the preparation method is that capsule further is made in the composition freeze-dried powder or is pressed into piece
Agent.
Composition of the present invention is as the application with hypoglycemic or effect for reducing blood fat drug or health care product.
Composition of the present invention is as the application with kidney tonifying or the drug or health care product of function of invigorating spleen.
Composition of the present invention is as the application with liver protecting or the drug or health care product of antialcoholism action.
The utility model has the advantages that (1) present invention using miracle fruit leaf as raw material, provides and a kind of completely new has medical treatment and health purpose
Composition；(2) composition of the present invention has good hypoglycemic, reducing blood lipid, liver protecting and weight-reducing etc.
Effect, can be used as health care product or drug uses.
Specific embodiment
The present invention is explained further below in conjunction with specific embodiment, but embodiment does not do any type of limit to the present invention
It is fixed.
Embodiment 1
By miracle fruit leaf 1kg；Wheat herb 1kg；Qingqian Willow leaf 0.5kg；Dried orange peel 0.1kg is uniformly mixed, is then added
15kg water, heating and refluxing extraction；Extracting solution is concentrated under reduced pressure, is then placed in freeze drier and is freeze-dried, obtains composition jelly
Dry powder.
Embodiment 2
By miracle fruit leaf 1kg；Wheat herb 1kg；Qingqian Willow leaf 1kg；Dried orange peel 0.3kg is uniformly mixed, 15kg is then added
Water, heating and refluxing extraction；Extracting solution is concentrated under reduced pressure, is then placed in freeze drier and is freeze-dried, obtains composition freeze-dried powder.
Embodiment 3
By miracle fruit leaf 1.5kg；Wheat herb 1.5kg；Qingqian Willow leaf 0.5kg；Dried orange peel 0.1kg, be uniformly mixed, then plus
Enter 15kg water, heating and refluxing extraction；Extracting solution is concentrated under reduced pressure, is then placed in freeze drier and is freeze-dried, obtains composition
Freeze-dried powder.
The hypoglycemic experiment of embodiment 4
Half male and half female mouse 60 are taken, is randomly divided into 6 groups by weight, every group 10, respectively blank control group (10ml/
Kg water), model control group (10ml/kg water), miracle fruit leaf water extract freeze-dried powder is (by miracle fruit leaf water heating and refluxing extraction
Obtained by freeze-drying), composition group (composition freeze-dried powder that embodiment 1 ~ 3 is prepared) be administered according to following table, on 7th
Interior daily gastric infusion is primary, and stomach-filling volume is 10ml/kg, and fasting 5 hours before last dose are removed after last dose 2 hours
Outside blank control group, glucose 2g/kg is injected intraperitoneally in remaining each group, 0.5,1 and 2 hour after injectable dextrose monohydrate,
Animal is put to death, blood is taken, blood glucose is surveyed with glucose oxidase method.Test result is shown in Table 1.
From upper table data as can be seen that the composition freeze-dried powder that is prepared of embodiment 1 ~ 3 have it is significant hypoglycemic
Effect, can be such that blood glucose returns to normal after mouse injectable dextrose monohydrate in 2h.Its blood sugar decreasing effect is also significantly better than individually
Use miracle fruit leaf water extract freeze-dried powder.
5 lipid-lowering test of embodiment
Rat 60 are taken, half male and half female is divided into chow diet group (feeding normal diet), high lipid food group, miracle fruit leaf water
Extract freeze-dried powder group (by obtaining after miracle fruit leaf water heating and refluxing extraction through freeze-drying), composition group (make by embodiment 1 ~ 3
Standby obtained composition freeze-dried powder), every group is 12, is weighed, and tail vein takes blood, measures serum lipid concentrations.Miracle fruit leaf water
The combination that extract freeze-dried powder group and composition component are not prepared with 2g miracle fruit leaf water extract freeze-dried powder group or embodiment 1 ~ 3
Object freeze-dried powder is mixed with 1kg high lipid food, feeds each group rat by group, free water is weighed 1 time every 10d.Continuously give
After medicine 40 days, animal is put to death, abdominal vein takes blood, measures blood lipid and hemorheology index.With enzyme process, Precipitation Determination complete
On automatic biochemistry analyzer measure serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and
Low density lipoprotein cholesterol (LDL-C) content.Lipid-lowering test the results are shown in Table 2.
As can be seen that the composition freeze-dried powder that embodiment 1 ~ 3 is prepared has significant reducing blood lipid from upper table data
Effect can significantly reduce total cholesterol (TC), triglycerides (TG), high density lipoprotein level in the mouse blood for feeding high lipid food
The content of white cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C)；And its effect for reducing blood fat is better than miracle fruit leaf
Water extract freeze-dried powder.
6 liver protecting of embodiment and experiment of relieving the effect of alcohol
Taking Kun Ming mice 60, male and female dual-purpose, 18~20g of weight is randomly divided into 5 groups, and every group 12, if 4 groups are given
Medicine group, (administration group uses embodiment 1 ~ 3 composition freeze-dried powder and miracle fruit leaf water extract freeze-dried powder that are prepared) and 1 group are not
The control group of administration.Each group stomach-filling to wine (53 degree of white wine) 0.4ml/ only, control group to 30min before wine, stomach-filling water supply 0.4ml,
Each administration group is to 30min before wine, gastric infusion, dosage 0.1g/kg.To 30min clock after drinking, take blood measuring blood pure and strong
Malonaldehyde (MDA) content in degree, alcohol dehydrogenase (ADH) activity and liver, the results are shown in Table 3.
It is more obvious than the blood alcohol concentration in control group to can be seen that the blood alcohol concentration in administration group mouse blood through upper table data
It reduces.Illustrate that composition freeze-dried powder of the present invention has good antialcoholism action.In another aspect administration group mouse blood
ADH activity be apparently higher than control group, MDA content is also significantly lower than control group.Illustrate composition freeze-dried powder of the present invention
It can increase the activity of ADH and reduce the effect of MDA content.Illustrate that composition freeze-dried powder of the present invention is imitated with good protect liver
Fruit.Show composition of the present invention by comparing with the experimental data for being administered alone miracle fruit leaf water extract freeze-dried powder group
The liver protecting effect of freeze-dried powder will be substantially better than miracle fruit leaf water extract freeze-dried powder.
Claims (10)
1. a kind of composition using miracle fruit leaf as primary raw material has in hypoglycemic or effect for reducing blood fat drug in preparation
Application,
The composition is made of the raw material of following parts by weight: 10~15 parts of miracle fruit leaf；10~15 parts of wheat herb；Green money
5~10 parts of willow leaf；1~3 part of dried orange peel；
The preparation method of the composition, comprises the following steps: miracle fruit leaf, wheat herb, Qingqian Willow leaf and dried orange peel are mixed
It after conjunction, is extracted with water, is drying to obtain after concentration.
2. application according to claim 1, which is characterized in that the composition is made of the raw material of following parts by weight:
10~15 parts of miracle fruit leaf；10~15 parts of wheat herb；5 parts of Qingqian Willow leaf；1 part of dried orange peel.
3. application according to claim 1, which is characterized in that the composition is made of the raw material of following parts by weight:
10 parts of miracle fruit leaf；10 parts of wheat herb；5 parts of Qingqian Willow leaf；1 part of dried orange peel.
4. application according to claim 1, which is characterized in that the preparation method of the composition comprises the following steps:
After miracle fruit leaf, wheat herb, Qingqian Willow leaf and dried orange peel are mixed, with water heating and refluxing extraction, through being freeze-dried after concentration
Composition freeze-dried powder.
5. application according to claim 4, which is characterized in that capsule is made in the composition freeze-dried powder or is pressed into
Tablet.
6. a kind of composition using miracle fruit leaf as primary raw material is in the drug that preparation has liver protecting or antialcoholism action
Application,
The composition is made of the raw material of following parts by weight: 10~15 parts of miracle fruit leaf；10~15 parts of wheat herb；Green money
5~10 parts of willow leaf；1~3 part of dried orange peel；
The preparation method of the composition, comprises the following steps: miracle fruit leaf, wheat herb, Qingqian Willow leaf and dried orange peel are mixed
It after conjunction, is extracted with water, is drying to obtain after concentration.
7. application according to claim 6, which is characterized in that the composition is made of the raw material of following parts by weight:
10~15 parts of miracle fruit leaf；10~15 parts of wheat herb；5 parts of Qingqian Willow leaf；1 part of dried orange peel.
8. application according to claim 6, which is characterized in that the composition is made of the raw material of following parts by weight:
10 parts of miracle fruit leaf；10 parts of wheat herb；5 parts of Qingqian Willow leaf；1 part of dried orange peel.
9. application according to claim 6, which is characterized in that the preparation method of the composition comprises the following steps:
After miracle fruit leaf, wheat herb, Qingqian Willow leaf and dried orange peel are mixed, with water heating and refluxing extraction, through being freeze-dried after concentration
Composition freeze-dried powder.
10. application according to claim 9, which is characterized in that capsule or pressure is made in the composition freeze-dried powder
At tablet.
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106606518A (en) * | 2015-10-22 | 2017-05-03 | 台山市龙飞园林有限公司 | Applications of Synsepalum dulcificum Daniell leaf extract product in preparing drugs or healthcare products capable of reducing blood glucose or reducing blood fat |
| CN108740219A (en) * | 2018-07-14 | 2018-11-06 | 泉州师范学院 | The preparation method and its usage of miracle fruit leaf soaking object and function tea beverage |
| CN109315557A (en) * | 2018-11-16 | 2019-02-12 | 万顺宝(肇庆)实业有限公司 | A kind of miracle fruit compound tea and preparation method thereof with liver protecting |
| CN109588521A (en) * | 2019-01-16 | 2019-04-09 | 万顺宝(肇庆)实业有限公司 | A kind of miracle fruit composite health care beverage and preparation method thereof with reducing blood lipid protect liver |
| CN111110741A (en) * | 2019-12-31 | 2020-05-08 | 江门民康生物科技研究有限公司 | Extract prepared from Synsepalum dulcificum leaves as raw material and its application in preparation of medicine or health product with liver protecting effect |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103734606A (en) * | 2013-11-26 | 2014-04-23 | 明光市白云面粉有限公司 | Heat-clearing health care noodle and preparation method thereof |
| RU2013114904A (en) * | 2013-04-02 | 2014-10-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Дальневосточный государственный медицинский университет" Министерства здравоохранения Российской Федерации | OIL PROTECTIVE COMPOSITION |
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- 2015-06-19 CN CN201510343297.6A patent/CN104958588B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2013114904A (en) * | 2013-04-02 | 2014-10-10 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Дальневосточный государственный медицинский университет" Министерства здравоохранения Российской Федерации | OIL PROTECTIVE COMPOSITION |
| CN103734606A (en) * | 2013-11-26 | 2014-04-23 | 明光市白云面粉有限公司 | Heat-clearing health care noodle and preparation method thereof |
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