CN104958263A - Method for wrapping essential oil with low-temperature micropowder - Google Patents
Method for wrapping essential oil with low-temperature micropowder Download PDFInfo
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- CN104958263A CN104958263A CN201510415728.5A CN201510415728A CN104958263A CN 104958263 A CN104958263 A CN 104958263A CN 201510415728 A CN201510415728 A CN 201510415728A CN 104958263 A CN104958263 A CN 104958263A
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Abstract
The invention discloses a method for wrapping essential oil with low-temperature micropowder. The method comprises the following steps: (1) crushing medicine materials and auxiliary materials in a pharmaceutical preparation through a high-speed rotating turbine in a sealed condition to form micropowder, repeatedly extruding the micropowder by virtue of the high-speed rotating turbine in the crushing process to generate a certain amount of heat, fully dispersing and adsorbing the essential oil in the pharmaceutical preparation with the micropowder with certain heat; and (2) lowering the temperature of a sealing crushing system, extruding the micropowder containing the essential oil through the high-speed rotating turbine to form a plurality of microspheres in a low-temperature state, so that the essential oil is wrapped with the microspheres. According to the method disclosed by the invention, the effective components of the essential oil and the raw and auxiliary materials in the preparation are firmly wrapped to form a microcapsule containing the essential oil; and the microcapsule has certain pressure resistance and heat resistance, and can completely meet drying and heating in stirring, extruding and drying processes in softwood preparation in a preparation production technology.
Description
Technical field
The invention belongs to material processing field, be specifically related to the method for a kind of low-temperature fine powder parcel volatile oil.
Background technology
The volatile oil existed in Chinese medicine is that a class has bioactive composition, is also called quintessence oil.Usually it is the general name with the volatile oil composition immiscible with water of vapor distillation gained from Chinese medicine.Volatile oil is the oily liquids with special tangy under normal conditions, can be vaporized at normal temperatures, can be dissolved in dense ethanol and most of organic solvent, water-soluble hardly; More responsive on the impact of air, daylight and temperature, be easy to decompose and go bad.And volatile oil and biomembranous affinity poor, thus affect the treatment, its foreign odor causes patient not easily to accept.Maximum with oral formulations in research and clinical practice, main employing is made into soft gelatin capsule (Oleum Folium Artemisiae Argyi soft gelatin capsule), microencapsule tablet (Vitex chinensis Mill. leaf volatile oil microencapsule tablet), beta cyclodextrin clathrate, the dry breast of micropowder silica gel etc. and carries out administration.Adopt conventional mixed method, although there is the volatile oil active ingredient of part to be temporarily retained in raw and auxiliary material in the process of mixing, when the process volatile oil of volatile oil active ingredient by soft material processed and heating of granulating almost disappears completely, cause drug effect low.
Summary of the invention
Goal of the invention: for solving problems of the prior art, the invention provides the method for a kind of low-temperature fine powder parcel volatile oil, by not only having certain thermostability to also have certain resistance to pressure with the volatile oil of the microsphere parcel with certain heat.
Technical scheme: for realizing above-mentioned technical purpose, the present invention proposes the method for a kind of low-temperature fine powder parcel volatile oil, comprises the steps:
(1) medicine material in pharmaceutical preparation and adjuvant are carried out pulverizing by the turbine of high speed rotating under air-proof condition and form micropowder, micropowder is subject to repeatedly the extruding of turbine of high speed rotating and produces certain heat in the process pulverized, and the volatile oil in pharmaceutical preparation is fully disperseed by this micropowder with certain heat and adsorbs;
(2) reduce the temperature of sealing crushing system, make the micropowder containing volatile oil under low temperature state form many microspheres by the extruding of the turbine of high speed rotating, thus volatile oil is wrapped in microsphere.
Preferably, in step (1), the rotary speed of turbine is 2000 ~ 4000 turns/min.
In step (2), the temperature of sealing crushing system is reduced to 0 DEG C ~ 5 DEG C.
Beneficial effect: the present invention adopts, and " low-temperature fine powder parcel volatile oil technology " makes the raw and auxiliary material in volatile oil active ingredient and preparation firmly wrap, form the microcapsule ball containing volatile oil, microcapsule ball has certain resistance to pressure, thermostability, can meet the extruding in the soft material processed in production technology and the heating in drying completely.
Detailed description of the invention
The present invention is described in detail below by specific embodiment.
Embodiment 1 low-temperature fine powder wraps up the method for volatile oil in pleasant carbocisteine.
The stock and adjunct getting pleasant carbocisteine conventionally pretreatment in early stage becomes soft material, as the stock and adjunct of pleasant carbocisteine is prepared into soft material by the method according to patent CN201410765058.5, then the soft material obtained is carried out pulverizing by the turbine of high speed rotating under air-proof condition and form micropowder, micropowder is subject to repeatedly the extruding of turbine of high speed rotating and produces certain heat in the process pulverized, and the volatile oil in pharmaceutical preparation is fully disperseed by this micropowder with certain heat and adsorbs; Reduce the temperature to 0 DEG C of sealing crushing system, the micropowder containing volatile oil under low temperature state is made to form many microspheres by the extruding of the turbine of high speed rotating, thus volatile oil is wrapped in microsphere, then the microsphere obtained conventionally is prepared into tablet or pill.The Strobilus Pini in pleasant carbocisteine contains the volatile oil of about 3%, and the relieving cough and asthma effect of Strobilus Pini volatile oil is the strongest.
Volatile oil content testing: get 2 groups of pleasant carbocisteines, wherein one group (A group) is the pleasant carbocisteine prepared according to the method for CN201410765058.5, the roughly same CN201410765058.5 of another group (B group) preparation method, unlike, after obtaining soft material, the method utilizing low-temperature fine powder of the present invention to wrap up volatile oil makes volatile oil be coated on micropowder surface, is then prepared into tablet further.
(1) thermostability experiment: the two groups of pleasant carbocisteines getting 1 gram respectively, respectively be divided into two parts, after a copy of it is soluble in water, measure wherein volatile oil content Vctr, another group is dried after 3 hours soluble in water more at different temperatures, utilize water soluble method to measure wherein volatile oil content Vtes, repeat above-mentioned experiment five times, the meansigma methods of measurement result is listed in the table below 1.
Table 1
| Project | A group | B group |
| Initial volatile oil content | 3％ | 3％ |
| Dry rear volatile oil content for 40 DEG C | 2.7％ | 3％ |
| Dry rear volatile oil content for 45 DEG C | 2.6％ | 3％ |
| Dry rear volatile oil content for 50 DEG C | 2.4％ | 3％ |
Result as can be seen from table 1, can effectively be fixed in pharmaceutical preparation by volatile oil by low-temperature fine powder parcel volatile oil, still remain unchanged playing volatile oil content after the heating in soft material processed, effectively pinned volatile oil.
(2) resistance to pressure test
Get two groups of pleasant carbocisteines of 1 gram respectively, respectively be divided into two parts, after a copy of it is soluble in water, measure wherein volatile oil content Vctr, another group is soluble in water again after different pressures tabletting, utilize water soluble method to measure wherein volatile oil content Vtes, repeat above-mentioned experiment five times, the meansigma methods of measurement result is listed in the table below 2.
Table 2
| Project | A group | B group |
| Initial volatile oil content | 3％ | 3％ |
| Volatile oil content after 10kg pressure tabletting | 2.75％ | 3％ |
| Volatile oil content after 15kg pressure tabletting | 2.65％ | 3％ |
| Volatile oil content after 20kg pressure tabletting | 2.40％ | 3％ |
Result as can be seen from table 2, can be fixed in pharmaceutical preparation by volatile oil by low-temperature fine powder parcel volatile oil effectively, through in soft material processed add compressed tablet after play volatile oil content and still remain unchanged, effectively pinned volatile oil.
The method of volatile oil in embodiment 2 low-temperature fine powder parcel ginseng and astragalus stomach strengthening granules.
The stock and adjunct getting ginseng and astragalus stomach strengthening granules conventionally pretreatment in early stage becomes soft material, as the stock and adjunct of ginseng and astragalus stomach strengthening granules is prepared into soft material by the method according to patent CN201410763715.2, then the soft material obtained is carried out pulverizing by the turbine of high speed rotating under air-proof condition and form micropowder, micropowder is subject to repeatedly the extruding of turbine of high speed rotating and produces certain heat in the process pulverized, and the volatile oil in pharmaceutical preparation is fully disperseed by this micropowder with certain heat and adsorbs; Reduce the temperature to 0 DEG C of sealing crushing system, the micropowder containing volatile oil under low temperature state is made to form many microspheres by the extruding of the turbine of high speed rotating, thus volatile oil is wrapped in microsphere, then the microsphere obtained conventionally is prepared into tablet or pill.Radix Inulae in ginseng and astragalus stomach strengthening granules, containing the volatile oil of about 2%, has the effect that aromatization becomes silted up.
Volatile oil content testing: get 2 groups of ginseng and astragalus stomach strengthening granules, wherein one group (A group) is the ginseng and astragalus stomach strengthening granules prepared according to the method for CN201410763715.2, the roughly same CN201410763715.2 of another group (B group) preparation method, unlike, after obtaining soft material, the method utilizing low-temperature fine powder of the present invention to wrap up volatile oil makes volatile oil be coated on micropowder surface, is then prepared into tablet further.
(1) thermostability experiment: the two groups of ginseng and astragalus stomach strengthening granules getting 1 gram respectively, respectively be divided into two parts, after a copy of it is soluble in water, measure wherein volatile oil content Vctr, another group is dried after 3 hours soluble in water more at different temperatures, utilize water soluble method to measure wherein volatile oil content Vtes, repeat above-mentioned experiment five times, the meansigma methods of measurement result is listed in the table below 3.
Table 3
| Project | A group | B group |
| Initial volatile oil content | 2％ | 2％ |
| Dry rear volatile oil content for 40 DEG C | 1.81％ | 2％ |
| Dry rear volatile oil content for 45 DEG C | 1.72％ | 2％ |
| Dry rear volatile oil content for 50 DEG C | 1.58％ | 2％ |
Result as can be seen from table 3, can effectively be fixed in pharmaceutical preparation by volatile oil by low-temperature fine powder parcel volatile oil, still remain unchanged playing volatile oil content after the heating in soft material processed, effectively pinned volatile oil.
(2) resistance to pressure test
Get two groups of ginseng and astragalus stomach strengthening granules of 1 gram respectively, respectively be divided into two parts, after a copy of it is soluble in water, measure wherein volatile oil content Vctr, another group is soluble in water again after different pressures tabletting, utilize water soluble method to measure wherein volatile oil content Vtes, repeat above-mentioned experiment five times, the meansigma methods of measurement result is listed in the table below 4.
Table 4
| Project | A group | B group |
| Initial volatile oil content | 2％ | 2％ |
| Volatile oil content after 10kg pressure tabletting | 1.75％ | 2％ |
| Volatile oil content after 15kg pressure tabletting | 1.62％ | 2％ |
| Volatile oil content after 20kg pressure tabletting | 1.41％ | 2％ |
Result as can be seen from table 4, can be fixed in pharmaceutical preparation by volatile oil by low-temperature fine powder parcel volatile oil effectively, through in soft material processed add compressed tablet after play volatile oil content and still remain unchanged, effectively pinned volatile oil.
Above-described embodiment is only the two methods example of the inventive method, and those skilled in the art should know, and method of the present invention is applicable to the process of the various preparation containing volatile oil, thus is better locked in the formulation by volatile oil.
Claims (3)
1. a method for low-temperature fine powder parcel volatile oil, is characterized in that, comprise the steps:
(1) medicine material in pharmaceutical preparation and adjuvant are carried out pulverizing by the turbine of high speed rotating under air-proof condition and form micropowder, micropowder is subject to repeatedly the extruding of turbine of high speed rotating and produces certain heat in the process pulverized, and the volatile oil in pharmaceutical preparation is fully disperseed by this micropowder with certain heat and adsorbs;
(2) reduce the temperature of sealing crushing system, make the micropowder containing volatile oil under low temperature state form many microspheres by the extruding of the turbine of high speed rotating, thus volatile oil is wrapped in microsphere.
2. the method for low-temperature fine powder parcel volatile oil according to claim 1, it is characterized in that, in step (1), the rotary speed of turbine is 2000 ~ 4000 turns/min.
3. the method for low-temperature fine powder parcel volatile oil according to claim 1, is characterized in that, in step (2), the temperature of sealing crushing system is reduced to 0 DEG C ~ 5 DEG C.
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| CN201510415728.5A CN104958263B (en) | 2015-07-15 | 2015-07-15 | A kind of method of low-temperature fine powder package volatile oil |
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| CN201510415728.5A CN104958263B (en) | 2015-07-15 | 2015-07-15 | A kind of method of low-temperature fine powder package volatile oil |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788738A (en) * | 2004-12-14 | 2006-06-21 | 李文军 | Medicinal preparation containing volatile oil and preparing method thereof |
| CN1872131A (en) * | 2006-04-27 | 2006-12-06 | 陕西唐宇药业股份有限公司 | Method for preparing Chinese traditional medicine of treating abscess, lymphadenitis, and pus and ulcer in cold nature |
| US20110150995A1 (en) * | 2009-12-22 | 2011-06-23 | Hemant Narahar Joshi | Solid Dosage Forms of Essential Oils |
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2015
- 2015-07-15 CN CN201510415728.5A patent/CN104958263B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788738A (en) * | 2004-12-14 | 2006-06-21 | 李文军 | Medicinal preparation containing volatile oil and preparing method thereof |
| CN1872131A (en) * | 2006-04-27 | 2006-12-06 | 陕西唐宇药业股份有限公司 | Method for preparing Chinese traditional medicine of treating abscess, lymphadenitis, and pus and ulcer in cold nature |
| US20110150995A1 (en) * | 2009-12-22 | 2011-06-23 | Hemant Narahar Joshi | Solid Dosage Forms of Essential Oils |
Non-Patent Citations (2)
| Title |
|---|
| 杜光等: "中药挥发油在制剂中的几种处理方法", 《时珍国医国药》 * |
| 武汉健民制药厂: "含挥发油中药制剂的探讨", 《中成药研究》 * |
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