CN104940721A - Traditional Chinese medicinal compound composition for treating neurogenic bladder disorders, preparation method and application thereof - Google Patents
Traditional Chinese medicinal compound composition for treating neurogenic bladder disorders, preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal compound composition for treating neurogenic bladder disorders. The composition is prepared from the following materials: 10 to 30 parts of coix seeds, 10 to 30 parts of scrophularia ningpoensis, 10 to 30 parts of astragalus membranaceus, 10 to 30 parts of atractylodes macrocephala, 10 to 30 parts of cornus officinalis, 10 to 30 parts of mantis egg case, 10 to 30 parts of rhizoma acori graminei, 2 to 10 parts of manis pentadactyla, 5 to 15 parts of alisma plantago-aquatica, 5 to 25 parts of semen plantaginis, 10 to 30 parts of rhizoma dioscoreae colletii, 10 to 30 parts of dried pyrrosia lingua leaves, 10 to 30 parts of tetrapanax papyriferus, 10 to 30 parts of lysimachia christinae hance, 10 to 30 parts of radix stephaniae tetrandrae, 10 to 30 parts of dried laminaria sporophytes, 10 to 25 parts of dried pyrrosia lingua leaves and 10 to 30 parts of gardenia jasminoides. According to the invention, the raw material compatibility prescription is selected based on traditional Chinese medical theory, and the compatibility of all components is scientific and reasonable; experimental results show that the traditional Chinese medicinal compound composition can effectively improve urinary tract symptoms and urodynamic related indicators, effectively restore the lower urinary tract function and reduce the bladder residual urine volume, and has a good curative effect on neurogenic bladder disorders.
Description
Technical field
The present invention relates to a kind of Chinese medicine compound, be specifically related to a kind of to there is Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease and preparation method thereof and application, belong to technical field of traditional Chinese medicine preparation.
Background technology
Neurogenic bladder disease refers to that nervous system disease or damage cause abnormality of nerve function, from the dysfunction causing bladder empties and storage, shows as urinary incontinence, urine retention, frequent micturition, the symptoms such as urgent micturition.Have a strong impact on patient's orthobiosis, reduce quality of life.The long-time a large amount of urine retention of intravesical, easily brings out urinary system infection, hydronephrosis, and even the complication such as renal failure, is the one of the main reasons causing death.Therefore, it is very important for actively and effectively treating in early days.
The classification of neurogenic bladder
Construct neurogenic bladder and urethra dysfunction can show as dysuria or urinary incontinence.Its main method has with the Lapides classification method showed according to clinical manifestation and the Urinary functional test of neurogenic urinary dysfunction; Based on the Hald-bradley classification method of nervous system lesion Anatomical orientation; Be applicable to the Bors-Comarr classification method of neurogenic dysuria caused by traumatic spinal cord injury; According to the world urine control credit meeting classification method that Urinary functional test data is main.Lapides classification method and international urine control credit can classification method be at present the most people the sorting technique be familiar with.This classification is simpler, but sensualness neurogenic bladder can clearly be described, motor paralytic bladder, unrestraint neurogenic bladder, reflex neuro source property bladder, autonomic nerve neurogenic bladder, wherein sensualness neurogenic bladder refers to that bladder is cut off caused urinary dysfunction to the Sensory nerve fibre of spinal cord or the ridge bundle that imports into of brain.The pathological changes initial stage occurs that bladder excessive is expanded, and causes detrusor contractions to weaken, and late period, Urinary functional test showed as Bladder Volume increase, and highly conforming properties and detrusor reflection are lowly.
Motor paralytic bladder refers to that the parasympathetic nervus motorius distribution arranging bladder is suffered to destroy caused urinary dysfunction.Early manifestation is that painful urine retention companion urinates and hesitates, and disease progression will cause forcing urine contractile function to lose, and Bladder Volume becomes large, and the low and abundant residues of detrusor reflection is urinated.
Uninhibited neurogenic bladder is often referred to nervous system disease and causes cortex to regulate the impaired caused neurogenic bladder of bundle.Micturition reflex maincenter is usually located at sacrum marrow, and cortex regulates the micturition centre of Shu Tongchang to sacrum marrow to have inhibitory action, therefore the result of pathological changes causes the micturition centre of sacrum marrow to be in the state of disinthibiting.Clinical main manifestations is frequent micturition, urgent micturition and urge incontinence.It is normal that Urinary functional test shows as bladder sensation, and filling period occurs that unrestraint is shunk repeatedly.
Reflex neuro source property bladder to refer between brain stem and sacrum marrow damage and the spinal shock phase terminate after vesicourethral functional status.Pathology can not get being characterized as bladder sensation and disappears, and namely full early stage bladder occurs Non inhibitory Contraction and occur urgency, causes urinary incontinence.
Autonomic nerve neurogenic bladder refers to from sacrum marrow and the phenomenon that is separated completely with sensory nerve of the nervus motorius being distributed in bladder.Pathophysiological features is for starting micturition reflex difficulty, the activity that detrusor areflexia shrinks, and bladder sensation disappears.Urinary functional test shows as low-tension Large Copacity bladder, and detrusor reflection is low, and bladder compliance lowers.
Medicine for neurogenic bladder disease in prior art is less, and unsatisfactory curative effect, Chinese medicine is in the retention for the treatment of urine, urinary system infection, hydronephrosis and the functional aspect such as not smooth of urinating have the advantage of its uniqueness, therefore, necessary under the guidance of theory of Chinese medical science, research one takes safety, and toxic and side effects is little, has the Traditional Chinese medicine compound composition of well treatment neurogenic bladder disease.
Summary of the invention
Goal of the invention: technical problem to be solved by this invention overcomes the deficiencies in the prior art, under Chinese medical theory, adopt the theory screening prescription of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, there is provided a kind of proportioning scientific and reasonable, medication is rigorous, take safety, side effect is little, has the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease very well.
Technical scheme: in order to realize above object, the technical scheme that the present invention takes is:
Have a Traditional Chinese medicine compound composition for treatment neurogenic bladder disease, it is made up of the raw material of following parts by weight:
Semen Coicis 10 ~ 30 parts, Radix Scrophulariae 10 ~ 30 parts, the Radix Astragali 10 ~ 30 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 30 parts, Fructus Corni 10 ~ 30 parts, Ootheca Mantidis 10 ~ 30 parts, Rhizoma Acori Graminei 10 ~ 30 parts, Squama Manis 2 ~ 10 parts, Rhizoma Alismatis 5 ~ 15 parts, Semen Plantaginis 5 ~ 25 parts of ， Rhizoma Dioscoreae Septemlobae 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 30 parts, Medulla Tetrapanacis 10 ~ 30 parts, Herba Lysimachiae 10 ~ 30 parts, Radix Stephaniae Tetrandrae 10 ~ 30 parts, Thallus Laminariae (Thallus Eckloniae) 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 25 parts, Fructus Gardeniae 10 ~ 30 parts.
Preferably, the above-described Traditional Chinese medicine compound composition with treatment neurogenic bladder disease, it is made up of the raw material of following parts by weight:
Semen Coicis 20 ~ 30 parts, Radix Scrophulariae 20 ~ 30 parts, the Radix Astragali 20 ~ 30 parts, the Rhizoma Atractylodis Macrocephalae 20 ~ 30 parts, Fructus Corni 20 ~ 30 parts, Ootheca Mantidis 20 ~ 30 parts, Rhizoma Acori Graminei 20 ~ 30 parts, Squama Manis 2 ~ 6 parts, Rhizoma Alismatis 5 ~ 10 parts, Semen Plantaginis 10 ~ 15 parts of ， Rhizoma Dioscoreae Septemlobae 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 20 parts, Medulla Tetrapanacis 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts, Radix Stephaniae Tetrandrae 10 ~ 20 parts, Thallus Laminariae (Thallus Eckloniae) 10 ~ 20 parts, Folium Pyrrosiae 15 ~ 25 parts, Fructus Gardeniae 10 ~ 20 parts.
Preferably, the above-described Traditional Chinese medicine compound composition with treatment neurogenic bladder disease, it is made up of the raw material of following parts by weight:
Semen Coicis 30 parts, Radix Scrophulariae 30 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Corni 20 parts, Ootheca Mantidis 30 parts, Rhizoma Acori Graminei 20 parts, Squama Manis 5 parts, Rhizoma Alismatis 10 parts, Semen Plantaginis 15 parts of ， Rhizoma Dioscoreae Septemlobae 20 parts, Folium Pyrrosiae 20 parts, Medulla Tetrapanacis 20 parts, Herba Lysimachiae 20 parts, Radix Stephaniae Tetrandrae 20 parts, Thallus Laminariae (Thallus Eckloniae) 20 parts, Folium Pyrrosiae 15 parts, Fructus Gardeniae 20 parts.
The present invention, under Chinese medical theory, adopts the theory screening prescription of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, and the Traditional Chinese medicine compound composition preferably obtained can be used for preparation treatment neurogenic bladder disease drug.
Have a medicine for treatment neurogenic bladder disease, it makes the medicine of capsule, microcapsule, tablet, pill, granule, drop pill or oral liquid formulation by the extract of Traditional Chinese medicine compound composition provided by the invention and pharmaceutically acceptable carrier.
The preparation method with the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease of the present invention, it comprises the following steps:
(1) Semen Coicis is got by weight, Radix Scrophulariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Fructus Corni, add the ethanol of medical material gross weight 8 ~ 15 times amount, reflux, extract, 1 ~ 3 time, each 1 ~ 3 hour, merge extractive liquid, filter, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.14 ~ 1.16;
(2) Ootheca Mantidis is got by weight, Rhizoma Acori Graminei, Rhizoma Alismatis, Semen Plantaginis ， Rhizoma Dioscoreae Septemlobae, Folium Pyrrosiae, Medulla Tetrapanacis, Herba Lysimachiae, Radix Stephaniae Tetrandrae, Thallus Laminariae (Thallus Eckloniae), Folium Pyrrosiae and Fructus Gardeniae, add the water of medical material gross weight 8 ~ 16 times amount, decoct extraction 1 ~ 3 time, each 1 ~ 3 hour, merge decoction liquor, filter, the concentrate that filtrate is concentrated;
(3) get Squama Manis by weight, pulverize 80 ~ 100 mesh sieves;
(4) get the clear paste that step (1) prepares, the concentrate that step (2) prepares and step (3) pulverize the medicine that the Squama Manis powder that obtains and pharmaceutically acceptable carrier make capsule, microcapsule, tablet, pill, granule, drop pill or oral liquid formulation.
When the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease provided by the invention makes tablet, the extract of Traditional Chinese medicine compound composition and carrier lactose or corn starch, add magnesium stearate lubricant when needing, mix homogeneously, then tablet made by tabletting.
When the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease provided by the invention makes capsule, the extract of Traditional Chinese medicine compound composition and carrier lactose or corn starch mix homogeneously, granulate, then encapsulatedly makes capsule.
When the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease provided by the invention makes granule, the extract of Traditional Chinese medicine compound composition and diluent lactose or corn starch mix homogeneously, granulate, dry, make granule.
When the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease provided by the invention makes oral liquid, the extract of the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease is added water and cosolvent dissolving, adds syrup and prepare oral liquid.
Beneficial effect: provided by the invention have Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease and preparation method thereof and compared to the prior art have the following advantages:
1, the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease provided by the invention, according to the pathogenesis of Chinese medical theory and neurogenic bladder disease, choose material combination prescription, each component proportioning is scientific and reasonable, medication is rigorous, experimental result shows, Traditional Chinese medicine compound composition provided by the invention, has and well promote the excretion of urine, to neurogenic bladder disease, there is good therapeutic efficiency, and clinical test results shows, do not occur obvious untoward reaction, safety is good.
2, the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease provided by the invention, can be prepared into the medicine of various dosage form with pharmaceutically acceptable carrier easily, facilitate Clinical practice.
3, the preparation method with the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease provided by the invention, according to character and the pharmacological action of different Chinese crude drugs, filters out best extraction process by great many of experiments.Whole technological design is reasonable, can realize industrialized great production.
Detailed description of the invention
According to following embodiment, the present invention may be better understood.But those skilled in the art will readily understand, concrete material proportion, process conditions and result thereof described by embodiment only for illustration of the present invention, and should can not limit the present invention described in detail in claims yet.
Embodiment 1
1. have a medicine for treatment neurogenic bladder disease, it is made up of the raw material of following parts by weight:
Semen Coicis 30 parts, Radix Scrophulariae 30 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Corni 20 parts, Ootheca Mantidis 30 parts, Rhizoma Acori Graminei 20 parts, Squama Manis 5 parts, Rhizoma Alismatis 10 parts, Semen Plantaginis 15 parts of ， Rhizoma Dioscoreae Septemlobae 20 parts, Folium Pyrrosiae 20 parts, Medulla Tetrapanacis 20 parts, Herba Lysimachiae 20 parts, Radix Stephaniae Tetrandrae 20 parts, Thallus Laminariae (Thallus Eckloniae) 20 parts, Folium Pyrrosiae 15 parts, Fructus Gardeniae 20 parts.
2. the preparation method with the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease of the present invention, it comprises the following steps:
(1) Semen Coicis 30 parts is got by weight, Radix Scrophulariae 30 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Corni 20 parts, adds the ethanol of medical material gross weight 10 times amount, reflux, extract, 3 times, each 2 hours, merge extractive liquid, filter, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.14 ~ 1.16;
(2) Ootheca Mantidis 30 parts is got by weight, Rhizoma Acori Graminei 20 parts, Rhizoma Alismatis 10 parts, Semen Plantaginis 15 parts of ， Rhizoma Dioscoreae Septemlobae 20 parts, Folium Pyrrosiae 20 parts, Medulla Tetrapanacis 20 parts, Herba Lysimachiae 20 parts, Radix Stephaniae Tetrandrae 20 parts, Thallus Laminariae (Thallus Eckloniae) 20 parts, Folium Pyrrosiae 15 parts, Fructus Gardeniae 20 parts, add the water of medical material gross weight 12 times amount, decoct extraction 3 times, each 2 hours, merge decoction liquor, filter, the concentrate that filtrate is concentrated;
(3) get Squama Manis 5 parts by weight, pulverize 80 ~ 100 mesh sieves;
(4) clear paste that step (1) prepares is got, the concentrate that step (2) prepares and step (3) are pulverized the Squama Manis powder that obtains and are added the right amount of auxiliary materials such as dextrin, fluidized bed granulation, make granule, be packaged into 10g/ bag, obtain final product.
Embodiment 2
1. have a medicine for treatment neurogenic bladder disease, it is made up of the raw material of following parts by weight:
Semen Coicis 20 parts, Radix Scrophulariae 20 parts, the Radix Astragali 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Corni 20 parts, Ootheca Mantidis 20 parts, Rhizoma Acori Graminei 20 parts, Squama Manis 2 parts, Rhizoma Alismatis 5 parts, Semen Plantaginis 10 parts of ， Rhizoma Dioscoreae Septemlobae 10 parts, Folium Pyrrosiae 10 parts, Medulla Tetrapanacis 10 parts, Herba Lysimachiae 10 parts, Radix Stephaniae Tetrandrae 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Folium Pyrrosiae 15 parts, Fructus Gardeniae 10 parts.
2. the preparation method with the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease of the present invention, it comprises the following steps:
(1) Semen Coicis 20 parts is got by weight, Radix Scrophulariae 20 parts, the Radix Astragali 20 parts, the Rhizoma Atractylodis Macrocephalae 20 parts, Fructus Corni 20 parts, adds the ethanol of medical material gross weight 12 times amount, reflux, extract, 2 times, each 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.14 ~ 1.16;
(2) Ootheca Mantidis 20 parts is got by weight, Rhizoma Acori Graminei 20 parts, Rhizoma Alismatis 5 parts, Semen Plantaginis 10 parts of ， Rhizoma Dioscoreae Septemlobae 10 parts, Folium Pyrrosiae 10 parts, Medulla Tetrapanacis 10 parts, Herba Lysimachiae 10 parts, Radix Stephaniae Tetrandrae 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Folium Pyrrosiae 15 parts, Fructus Gardeniae 10 parts, add the water of medical material gross weight 12 times amount, decoct extraction 3 times, each 2 hours, merge decoction liquor, filter, the concentrate that filtrate is concentrated;
(3) get Squama Manis 2 parts by weight, pulverize 80 ~ 100 mesh sieves;
(4) clear paste that step (1) prepares is got, the concentrate that step (2) prepares and step (3) pulverize the Squama Manis powder obtained, add purified water and syrup, fill obtains oral liquid, 10ml/ bottle, 100 DEG C of flowing steam sterilizations 30 minutes, to obtain final product.
Embodiment 3
1, have a medicine for treatment neurogenic bladder disease, it is made up of the raw material of following parts by weight:
Semen Coicis 10 parts, Radix Scrophulariae 10 parts, the Radix Astragali 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Corni 10 parts, Ootheca Mantidis 10 parts, Rhizoma Acori Graminei 10 parts, Squama Manis 2 parts, Rhizoma Alismatis 5 parts, Semen Plantaginis 5 parts of ， Rhizoma Dioscoreae Septemlobae 10 parts, Folium Pyrrosiae 10 parts, Medulla Tetrapanacis 10 parts, Herba Lysimachiae 10 parts, Radix Stephaniae Tetrandrae 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Folium Pyrrosiae 10 parts, Fructus Gardeniae 10 parts.
2. the preparation method with the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease of the present invention, it comprises the following steps:
(1) Semen Coicis 10 parts is got by weight, Radix Scrophulariae 10 parts, the Radix Astragali 10 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Fructus Corni 10 parts, adds the ethanol of medical material gross weight 8 times amount, reflux, extract, 2 times, each 2 hours, merge extractive liquid, filter, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.14 ~ 1.16;
(2) Ootheca Mantidis 10 parts is got by weight, Rhizoma Acori Graminei 10 parts, Squama Manis 2 parts, Rhizoma Alismatis 5 parts, Semen Plantaginis 5 parts of ， Rhizoma Dioscoreae Septemlobae 10 parts, Folium Pyrrosiae 10 parts, Medulla Tetrapanacis 10 parts, Herba Lysimachiae 10 parts, Radix Stephaniae Tetrandrae 10 parts, Thallus Laminariae (Thallus Eckloniae) 10 parts, Folium Pyrrosiae 10 parts, Fructus Gardeniae 10 parts, add the water of medical material gross weight 8 amount, decoct extraction 2 times, each 3 hours, merge decoction liquor, filter, the concentrate that filtrate is concentrated;
(3) get Squama Manis 2 parts by weight, pulverize 80 ~ 100 mesh sieves;
(4) clear paste that step (1) prepares is got, the concentrate that step (2) prepares and step (3) pulverize the Squama Manis powder obtained, add carrier lactose or corn starch, add magnesium stearate lubricant, mix homogeneously, then tablet made by tabletting.
The preparation of embodiment 4 capsule
1, have a medicine for treatment neurogenic bladder disease, it is made up of the raw material of following parts by weight:
Semen Coicis 30 parts, Radix Scrophulariae 30 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Corni 30 parts, Ootheca Mantidis 30 parts, Rhizoma Acori Graminei 30 parts, Squama Manis 10 parts, Rhizoma Alismatis 15 parts, Semen Plantaginis 25 parts of ， Rhizoma Dioscoreae Septemlobae 30 parts, Folium Pyrrosiae 30 parts, Medulla Tetrapanacis 30 parts, Herba Lysimachiae 30 parts, Radix Stephaniae Tetrandrae 30 parts, Thallus Laminariae (Thallus Eckloniae) 30 parts, Folium Pyrrosiae 25 parts, Fructus Gardeniae 30 parts.
2. the preparation method with the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease of the present invention, it comprises the following steps:
(1) Semen Coicis 30 parts is got by weight, Radix Scrophulariae 30 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Corni 30 parts, adds the ethanol of medical material gross weight 10 times amount, reflux, extract, 1 time, 3 hours, merge extractive liquid, filter, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.14 ~ 1.16;
(2) Ootheca Mantidis 30 parts is got by weight, Rhizoma Acori Graminei 30 parts, Rhizoma Alismatis 15 parts, Semen Plantaginis 25 parts of ， Rhizoma Dioscoreae Septemlobae 30 parts, Folium Pyrrosiae 30 parts, Medulla Tetrapanacis 30 parts, Herba Lysimachiae 30 parts, Radix Stephaniae Tetrandrae 30 parts, Thallus Laminariae (Thallus Eckloniae) 30 parts, Folium Pyrrosiae 25 parts, Fructus Gardeniae 30 parts, add the water of medical material gross weight 10 amount, decoct extraction 1 time, 3 hours, merge decoction liquor, filter, the concentrate that filtrate is concentrated;
(3) get Squama Manis 10 parts by weight, pulverize 80 ~ 100 mesh sieves;
(4) clear paste that step (1) prepares is got, the concentrate that step (2) prepares and step (3) pulverize the Squama Manis powder obtained, with carrier lactose or corn starch mix homogeneously, granulate, then encapsulatedly make capsule.
Embodiment 5 Study on clinical pharmacodynamics
One. experimental subject
Collect 150 routine neurogenic bladder disease patients, be divided into apoplexy group: male patient 35 example, women is 15 examples, the age average (58.28 ± 3.16) year; Diabetic groups: male patient 26 example, women be 24 example, the average patient age be (55.56 ± 3.69) year; Patient male 24 example in spinal cord injury group, women 26 example, the age average (57.13 ± 3.61) year.The clinical data of three groups of patients has comparability (P > 0.05).
Inclusive criteria
1. enter to organize patient and all meet NB diagnostic criteria; 2. enter to organize apoplexy group patient and meet apoplexy diagnostic criteria; 3. diabetic groups patient diagnoses with diabetes diagnostic criterion; 4. patient is all adult, has good judgement.
Exclusion standard
1. the past row bladder makes the disease that Lou art, surgical injury etc. cause dysuria; 2. the important organ such as the heart, brain serious disease; 3. patient's unconsciousness, or spiritedness disease, can not partner treatment person; 4. the person that suffers from coagulation disorders; 5. the patient of the dysuria that prostatic hyperplasia and other diseases cause is got rid of; 6. patient does not accept electrical acupuncture method person.
Two. Therapeutic Method
The granule that the Traditional Chinese medicine compound composition adopting the embodiment of the present invention 1 to prepare is made, morning every day, in, in each 1 time of evening, each 10g 7 days is one-period, takes 1 ~ 3 cycle continuously.
Three. experimental result
3.1 clinical efficacy evaluation criterias
3.1.1 dysuria classification
According to the situation that patient's Autonomous Control is urinated, dysuria is divided into urinary incontinence and urine retention two kinds of situations.
3.1.2 urine retention cosmetic effect evaluating method
Effective: can automatic micturition, having urine phenomenon of overflowing once in a while, ultrasound diagnosis prompting bladder RV be less than 200ml person.Invalid: dysuria symptom is without being clearly better, and B-mode ultrasonography shows that bladder RV is without obvious minimizing person.
3.1.3 urinary incontinence cosmetic effect evaluating method
Effective: frequent micturition, symptoms of urgency make moderate progress, micturition frequency test and appraisal raising 1 degree every day and above person.Invalid: frequent micturition, symptoms of urgency are without improvement, and every day, micturition frequency test and appraisal were without improver.
3.1.4 urinary incontinence micturition frequency evaluation standard
I degree: without urinary incontinence; II degree: urinary incontinence is firmly and when holding one's breath occurring; III degree: when urinary incontinence occurs in walking and activity; IV degree: upright and just occurred urinary incontinence when standing up.
3.2 results contrast
Relatively three groups of forward and backward urinary functions of patient treatment improve situation; Hydromechanics index before and after comparison therapy: residual urine volume (RV), the initial numerical value urinating meaning bladder capacity (FDV), Qmax (Qmax) and maximum bladder capacity (MCC), concrete detection method is undertaken by document relevant report.
3.3 statistical method
Statistical software SAS 6.12 software kit is adopted to carry out statistical analysis.Adopt respectively and analyze with independent samples t test in groups.Level of significance α=0.05.P<0.05 has statistical significance.
3.4 result
Take Granules in Treating that Traditional Chinese medicine compound composition that the embodiment of the present invention prepares prepares after 2 weeks, three groups of patients all have good clinical efficacy, forward and backward have clear improvement (P<0.05) of three groups of Urinary hydromechanics indexs treatment, specific experiment the results are shown in Table 1, table 2.
Table 1 three groups of therapeutic effect situations compare
Note: compared with ■, *, #P<0.05
Table 2 three groups of therapeutic effect situations compare
ml/s
Compare with before treatment, a P<0.05; Compare with diabetic groups after treatment, b, c P<0.05.
Shown by the experimental result of above table 1 and table 2, Traditional Chinese medicine compound composition provided by the invention has effect of well treatment neurogenic bladder disease, effective percentage reaches more than 84%, wherein to apoplexy cause have through source property bladder disorder more than 90% therapeutic effect.Above clinical test results shows, Traditional Chinese medicine compound composition provided by the invention is to apoplexy common clinically, the neurogenic bladder disease that diabetes and spinal cord injury group cause all has good therapeutic effect, and find no obvious adverse reaction in clinical trial process, clinical drug safety.
The present invention is according to Chinese medical theory determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, according to the pathogeny of neurogenic bladder disease, carry out scientific composition, through experimental study results which prove, Traditional Chinese medicine compound composition provided by the invention effectively can improve urinary tract symptom and Urinary functional test index of correlation, effectively recovers low urinary tract function, and residual urine volume is reduced, simultaneously can ensure Upper urinary tract function, can improve and improve the life quality of patient.
The present invention shows through same experimental verification, and the Traditional Chinese medicine compound composition that the embodiment of the present invention 2 to 4 prepares has effect of well treatment neurogenic bladder disease equally.
Above embodiment is only for illustrating technical conceive of the present invention and feature; its object is to allow person skilled in the art understand content of the present invention and to be implemented; can not limit the scope of the invention with this; all equivalences done according to spirit of the present invention change or modify, and all should be encompassed in protection scope of the present invention.
Claims (6)
1. have a Traditional Chinese medicine compound composition for treatment neurogenic bladder disease, it is characterized in that, it is made up of the raw material of following parts by weight:
Semen Coicis 10 ~ 30 parts, Radix Scrophulariae 10 ~ 30 parts, the Radix Astragali 10 ~ 30 parts, the Rhizoma Atractylodis Macrocephalae 10 ~ 30 parts, Fructus Corni 10 ~ 30 parts, Ootheca Mantidis 10 ~ 30 parts, Rhizoma Acori Graminei 10 ~ 30 parts, Squama Manis 2 ~ 10 parts, Rhizoma Alismatis 5 ~ 15 parts, Semen Plantaginis 5 ~ 25 parts of ， Rhizoma Dioscoreae Septemlobae 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 30 parts, Medulla Tetrapanacis 10 ~ 30 parts, Herba Lysimachiae 10 ~ 30 parts, Radix Stephaniae Tetrandrae 10 ~ 30 parts, Thallus Laminariae (Thallus Eckloniae) 10 ~ 30 parts, Folium Pyrrosiae 10 ~ 25 parts, Fructus Gardeniae 10 ~ 30 parts.
2. the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease according to claim 1, it is characterized in that, it is made up of the raw material of following parts by weight:
Semen Coicis 20 ~ 30 parts, Radix Scrophulariae 20 ~ 30 parts, the Radix Astragali 20 ~ 30 parts, the Rhizoma Atractylodis Macrocephalae 20 ~ 30 parts, Fructus Corni 20 ~ 30 parts, Ootheca Mantidis 20 ~ 30 parts, Rhizoma Acori Graminei 20 ~ 30 parts, Squama Manis 2 ~ 6 parts, Rhizoma Alismatis 5 ~ 10 parts, Semen Plantaginis 10 ~ 15 parts of ， Rhizoma Dioscoreae Septemlobae 10 ~ 20 parts, Folium Pyrrosiae 10 ~ 20 parts, Medulla Tetrapanacis 10 ~ 20 parts, Herba Lysimachiae 10 ~ 20 parts, Radix Stephaniae Tetrandrae 10 ~ 20 parts, Thallus Laminariae (Thallus Eckloniae) 10 ~ 20 parts, Folium Pyrrosiae 15 ~ 25 parts, Fructus Gardeniae 10 ~ 20 parts.
3. the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease according to claim 2, it is characterized in that, it is made up of the raw material of following parts by weight:
Semen Coicis 30 parts, Radix Scrophulariae 30 parts, the Radix Astragali 30 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Fructus Corni 20 parts, Ootheca Mantidis 30 parts, Rhizoma Acori Graminei 20 parts, Squama Manis 5 parts, Rhizoma Alismatis 10 parts, Semen Plantaginis 15 parts of ， Rhizoma Dioscoreae Septemlobae 20 parts, Folium Pyrrosiae 20 parts, Medulla Tetrapanacis 20 parts, Herba Lysimachiae 20 parts, Radix Stephaniae Tetrandrae 20 parts, Thallus Laminariae (Thallus Eckloniae) 20 parts, Folium Pyrrosiae 15 parts, Fructus Gardeniae 20 parts.
4. the application of the Traditional Chinese medicine compound composition with treatment neurogenic bladder disease described in any one of claims 1 to 3 in preparation treatment neurogenic bladder disease drug.
5. one kind has the medicine for the treatment of neurogenic bladder disease, it is characterized in that, it makes the medicine of capsule, microcapsule, tablet, pill, granule, drop pill or oral liquid formulation by the extract of the Traditional Chinese medicine compound composition described in any one of claims 1 to 3 and pharmaceutically acceptable carrier.
6. the preparation method with the Traditional Chinese medicine compound composition for the treatment of neurogenic bladder disease described in any one of claims 1 to 3, is characterized in that, comprise the following steps:
(1) Semen Coicis is got by the parts by weight described in any one of claims 1 to 3, Radix Scrophulariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae and Fructus Corni, add the ethanol of medical material gross weight 8 ~ 15 times amount, reflux, extract, 1 ~ 3 time, each 1 ~ 3 hour, merge extractive liquid, filtered, when filtrate is concentrated into 60 DEG C, relative density is the clear paste of 1.14 ~ 1.16;
(2) Ootheca Mantidis is got, Rhizoma Acori Graminei, Rhizoma Alismatis by the parts by weight described in any one of claims 1 to 3, Semen Plantaginis ， Rhizoma Dioscoreae Septemlobae, Folium Pyrrosiae, Medulla Tetrapanacis, Herba Lysimachiae, Radix Stephaniae Tetrandrae, Thallus Laminariae (Thallus Eckloniae), Folium Pyrrosiae and Fructus Gardeniae, add the water of medical material gross weight 8 ~ 16 times amount, decoct extraction 1 ~ 3 time, each 1 ~ 3 hour, merge decoction liquor, filter, the concentrate that filtrate is concentrated;
(3) get Squama Manis by the parts by weight described in any one of claims 1 to 3, pulverize 80 ~ 100 mesh sieves;
(4) get the clear paste that step (1) prepares, the concentrate that step (2) prepares and step (3) pulverize the medicine that the Squama Manis powder that obtains and pharmaceutically acceptable carrier make capsule, microcapsule, tablet, pill, granule, drop pill or oral liquid formulation.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095760A (en) * | 2007-07-05 | 2008-01-02 | 北京艺信堂医药研究所 | Chinese traditional medicine composition for treating diabetes neurogenic bladder |
| CN104587419A (en) * | 2013-10-30 | 2015-05-06 | 青岛百草汇中草药研究所 | Traditional Chinese medicine used for treating uracratia |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095760A (en) * | 2007-07-05 | 2008-01-02 | 北京艺信堂医药研究所 | Chinese traditional medicine composition for treating diabetes neurogenic bladder |
| CN104587419A (en) * | 2013-10-30 | 2015-05-06 | 青岛百草汇中草药研究所 | Traditional Chinese medicine used for treating uracratia |
Non-Patent Citations (3)
| Title |
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| 檀金川等: "《中西医结合肾病学》", 31 July 2011, 河北科学技术出版社 * |
| 陈涛: "《糖尿病良方妙法》", 30 November 2008, 科学技术文献出版社 * |
| 马国海等: "中医药治疗糖尿病神经源性膀胱进展", 《光明中医》 * |
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