CN1049350C - Medicine for psoriasis - Google Patents
Medicine for psoriasis Download PDFInfo
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- CN1049350C CN1049350C CN96121234A CN96121234A CN1049350C CN 1049350 C CN1049350 C CN 1049350C CN 96121234 A CN96121234 A CN 96121234A CN 96121234 A CN96121234 A CN 96121234A CN 1049350 C CN1049350 C CN 1049350C
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- radix
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract
The present invention relates to a medicine for treating psoriasis, which is prepared from Chinese medicinal herbs of flavescent sophora root, red sage root, safflower, red peony root, tree peony bark, angelica, fleeceflower root, dittany, fineleaf schizonepeta herb, honeysuckle flower, zedoary, prism tuber, unprocessed rehmannia root, figwort root and cicada slough. The decoction of the angelica, the fineleaf schizonepeta herb, the prism tuber and zedoary volatile oil and the decoction of the flavescent sophora root, the red peony root, the dittany, the unprocessed rehmannia root, the figwort root and the cicada slough are extracted to be concentrated into thick paste; the red sage root, the safflower, the tree peony bark, the fleeceflower root and the honeysuckle flower are crushed into fine powder. Volatile oil thick paste is dissolved in ethanol and then is sprayed into the fine powder, and then the fine powder is uniformly mixed with the thick paste of the decoction to prepare pills. Thus, the medicine has the special treatment effect on wind heat and blood dryness type psoriasis, blood deficiency and wind dryness type psoriasis and stasis skin type psoriasis.
Description
The present invention relates to the psoriatic Chinese patent medicine of a kind of treatment.
The psoriatic Chinese patent medicine of current treatment mainly contains: malicious black pigment used by women in ancient times to paint their eyebrows ball (production of Yulin Prefecture, the Shaanxi Province pharmaceutical factory of traditional Chinese medicine), KEYIN PIAN (production of Beijing's pharmacy five factories), XIAOYIN PIAN (Huaxing Pharmaceutical Co., Ltd., Heilongjiang Prov.'s production), wherein XIAOYIN PIAN is unique since the establishment of the nation national new drug, it also is current one of the medicine that the psoriatic trusts that is subjected to deeply, but above-mentioned three kinds of medicines are all with heat-clearing and toxic substances removing, removing heat from blood is main, be intended to treatment " wind heat blood-dryness type " psoriasis, wait other disease type unsatisfactory curative effect and " blood-deficiency and wind-dry type " reached " stasis of blood stagnate skin type ".
The objective of the invention is to go up from clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, blood enriching and dryness moistening from filling a prescription, dispelling wind is antipruritic starts with, and makes this medicine to the psoriasis of various different disease types special curative effect be arranged all.
The objective of the invention is to realize: select Chinese herbal medicine Radix Sophorae Flavescentis 213 grams for use by following method, Radix Salviae Miltiorrhizae 213 grams, Flos Carthami, Radix Paeoniae Rubra, Cortex Moutan, Radix Angelicae Sinensis, Radix Polygoni Multiflori, each 146 gram of Cortex Dictamni, Herba Schizonepetae, each 126 gram of Flos Lonicerae, Rhizoma Curcumae, rhizoma sparganic, Radix Rehmanniae, Radix Scrophulariae, each 78 gram of Periostracum Cicadae, extract Radix Angelicae Sinensis, Herba Schizonepetae, rhizoma sparganic, the volatile oil and the Radix Sophorae Flavescentis of Rhizoma Curcumae mixing medical material, Radix Paeoniae Rubra, Cortex Dictamni, Radix Rehmanniae, Radix Scrophulariae, Periostracum Cicadae mixes medical material decocting liquid, the two is concentrated into relative density respectively is 1.25～1.30 thick paste, Radix Salviae Miltiorrhizae, Flos Carthami, Cortex Moutan, Radix Polygoni Multiflori, Flos Lonicerae mixes pulverizing medicinal materials and becomes fine powder, the volatile oil thick paste is dissolved in ethanol sprays in the fine powder, close even pill with decocting liquid thick paste again and form.
In the present invention's ten five tastes Chinese herbal medicine, Radix Sophorae Flavescentis, Radix Salviae Miltiorrhizae are monarch drug, and the Radix Sophorae Flavescentis bitter cold is returned lung stomach warp, and the effect of heat-clearing and toxic substances removing, dispelling wind for relieving itching is arranged, kind scabies and the skin pruritus controlled; The Radix Salviae Miltiorrhizae bitter cold is returned lung stomach warp, have invigorate blood circulation, nourish blood, the effect of removing heat from blood, and control malignant boil, scabies, the superfluous toxic swelling of cherry, erysipelas.Cortex Moutan, Radix Paeoniae Rubra, Flos Carthami are ministerial drug, wherein Cortex Moutan, Radix Paeoniae Rubra clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; The Cortex Moutan toil, be slightly cold, GUIXIN Liver and kidney warp is the medicine of removing heat from blood heat; The Radix Paeoniae Rubra hardship is slightly cold, and returns Liver Channel promoting the circulation of blood removing blood stasis with potent drugs, moves back heat in blood, attacks the carbuncle skin ulcer, controls scabies; The hot temperature of Flos Carthami, the GUIXIN Liver Channel can be invigorated blood circulation and be moisturized, and pain-relieving powder for treating is swollen.Assistant is with rhizoma sparganic, Rhizoma Curcumae, the removing blood stasis dissipating blood stasis, and the arduous temperature of rhizoma sparganic is returned the liver spleen channel, the gas in can removing blood stasis; The arduous temperature of Rhizoma Curcumae is returned the liver spleen channel, the blood in the energy dispelling the stagnated QI, and the power that its dispelling the stagnated QI of the two mutual reinforcement between is opened the stasis of blood is strong.Flos Lonicerae, Cortex Dictamni heat-clearing and toxic substances removing, Flos Lonicerae is sweet cold, returns lung heart channel, all toxic swellings that can disappear, carbuncle scabies; Cortex Dictamni is sweet cold, returns the taste urinary bladder channel, controls all pyretic toxicity aversion to wind, and wind skin ulcer scabies is red mashed.Radix Angelicae Sinensis, Radix Polygoni Multiflori blood enriching and dryness moistening can moisten and support skin and make skin soft and moist and white scales must move back, and again with promoting blood circulation and breaking stagnation medicine mutually 5, make it removing blood stasis and just do not hinder.Radix Rehmanniae, Radix Scrophulariae removing heat from blood are moisturized, and have both helped Radix Salviae Miltiorrhizae, Cortex Moutan with removing heat from blood, assist Radix Angelicae Sinensis, Radix Polygoni Multiflori to moisturize again.Herba Schizonepetae, Periostracum Cicadae dispelling wind are antipruritic, and Herba Schizonepetae is dispeled the wind and the skin ulcer that disappears; Periostracum Cicadae is controlled the sores ulceration of skin wind heat.More than all medicines play clearing away heat and cooling blood altogether, blood circulation promoting and blood stasis dispelling, blood enriching and dryness moistening, the dispelling wind for relieving itching effect all obtains satisfied especially effect so " wind heat blood-dryness type ", " blood-deficiency and wind-dry type " are reached psoriasises such as " stasis of bloods stagnate skin type " when clinical.
This Chinese patent medicine using method is each 6 grams of adult, and every day 3 times, 3 months is a course of treatment.
It is as follows that this Chinese patent medicine and function cure mainly relevant Pharmacodynamic test of active extract data:
[summary]
Two kinds of psoriasis model of formation of mouse vagina epithelial cell mitosis and mouse tail granular layer scale have been selected in this test for use, two kinds of antiinflammatory models have been selected for use, the one, it is swollen that xylol causes mouse ear, and the 2nd, histamine is caused the rat skin capillary permeability strengthen; Selected two kinds of antiallergic models for use, the one, to the influence of Cavia porcellus allergic asthma, the 2nd, to the influence of Cavia porcellus anaphylactic shock reaction; Investigate simultaneously the influence of mouse T lymphocyte and possible treatment mechanism.The result shows: this Chinese patent medicine can suppress mouse vagina epithelial cell mitosis significantly, mouse tail scale epidermis is had the significant particle layer facilitate effect, can improve mouse blood T lymphocyte percentage ratio significantly, obviously suppress the mice caused by dimethylbenzene xylene auricle edema, rat skin capillary permeability due to the histamine is strengthened, have significant inhibitory effect, can obviously prolong the incubation period of Cavia porcellus asthma reaction due to the histamine, the time that the deferrable allergy symptoms occurs.
[test objective]
For the main disease to be treated of this medicine provides preclinical animal experiment data.
[being subjected to the reagent thing]
The curing psoriasis pill is provided by Huaxing Pharmaceutical Co., Ltd., Heilongjiang Prov., lot number: 930718.
It is 1.9g that every gram contains total medical material, and every gram contains matrine must not be less than 1.3mg.
Compound method: the curing psoriasis pill adds to boil puts cold distilled water immersion, grinds, and adding distil water is diluted to the curing psoriasis pill suspension of desired concn while grinding, and the time spent shakes up.
[control drug and reagent]
Positive control drug is an XIAOYIN PIAN, and authentication code is provided by Huaxing Pharmaceutical Co., Ltd., Heilongjiang Prov.: (91) are defended the accurate word Z-69 of medicine number, lot number: 930418, and content: the heavy 0.3g of substrate, every contains matrine and must not be less than 0.3mg.
Compound method: some of cancellation silver strips, remove sugar-coat, grind, add to boil while grinding and put cold distilled water to needs concentration.
The rare female phenol of second, Shanghai the 9th pharmaceutical factory, lot number: 930204;
Colchicine, Yangyuan County's biochemical test factory, lot number: 870410;
Histamine phosphate, Shanghai Inst. of Biochemistry, Chinese Academy of Sciences, lot number: 9110291;
Dimethylbenzene, Harbin City's chemical reagent factory, lot number: 8341.
According to train of thought orchid, Shanghai chemical reagent purchasing and supply station is sold, and row is known school-run factories' packing, lot number: 82-11-02.
[animal]
Kunming kind white mice provides the quality certification by Heilongjiang Province college of traditional Chinese medicine Experimental Animal Center: doctor animal word 09-2-2; The WKA rat is provided the quality certification by institute of oncology, Heilongjiang Province laboratory animal room: doctor animal word 09-3-2; Cavia porcellus is provided by Heilongjiang Province's veterinary institute.
[mathematical statistics]
New drug pharmacology statistical procedure (NDST)
[test method and result]
1, the mitotic influence of pair cell: 40 of mices, body weight 21 ± 1g, female, lumbar injection diethylstilbestrol 0.2mg/ only 1 time on the 1st, is divided into 4 groups, 10 every group then at random for three days on end.High and low two dosage of pill administration component of the present invention, 1g, 1 time on the 1st, positive controls, 1g XIAOYIN PIAN liquid, 1 time on the 1st; The blank group, 1g is with the volume distilled water.The administration group gives medicine after all injecting diethylstilbestrol 1h the last time, continuous 4 days.Each organizes last, and to irritate stomach unified time be at 8 o'clock in the morning, and 10 o'clock lumbar injection colchicine 0.2mg/10g body weight were taken off neck and put to death at 3 o'clock in afternoon.Get whole vagina tissues, 10% formalin fixed, paraffin embedding, HE dyeing.Count the mitotic cell number in 400 basal cells, convert out the mitosis number of per 100 basal cells, be called mitotic index, do the t check between each group.The results are shown in Table 1.The result shows: pill administration group of the present invention is compared with the blank group all extremely significantly meaning, shows that pill of the present invention can suppress mouse vagina epithelial cell mitosis by the utmost point significantly.
2, the influence that keratinization of epidermis is formed: 40 of mices, body weight 21 ± 1g, male and female half and half are divided into 4 groups at random.High and low two dosage of pill administration component of the present invention, positive drug control group gives XIAOYIN PIAN liquid, and the blank group gives with the volume distilled water.Each is organized equal 1g and gives medicine, and every day 1 time, continuous 4 days, 2h behind the last medicine put to death mice, gets dorsal part skin one rectangular (about the 1.0～0.3cm) of the about 1.5cm of Mus back range root place, uses 10% formalin fixed, paraffin embedding film-making, HE dyeing.Count total scale number and the scale number of granular cell layer (＞3 granular cells are arranged in passerby) is arranged.Every Mus is observed 5 of interrupted sections, with the scale number of granular layer is arranged in the section, is converted to the scale number that granular layer is arranged in per 100 scales.Relatively check between group with t.The results are shown in Table 2.Table 2 is the result show, each administration group is compared with the blank group all extremely significantly meaning, illustrates that promptly Xiaoyin health ball has the significant particle layer to Mus tail scale epidermis and facilitates effect.
3, to the influence of blood T lymphocyte percentage ratio: testing 2, face when putting to death animal, get blood (anticoagulation) 0.5ml with the eyeball excise method, adding distil water 4.5ml is inverted, transparent after, add 1.7% normal saline solution, shake up, centrifugal (1000 rev/mins, 10 minutes) inclining supernatant, collect lymphocyte, smear, natural drying, acid α-Yi Suannaizhi enzyme (ANAE) dyeing, and count 100 lymphocytes, calculate the lymphocytic percentage ratio of T, relatively with the t check, the results are shown in Table 3 between group.Table 3 is the result show, the lymphocytic percentage ratio of administration group T has been compared extremely significantly meaning with matched group, point out pill of the present invention can improve mouse blood T lymphocyte percentage ratio significantly.
4, to the bullate influence of Mice Auricle caused by dimethylbenzene xylene: 40 of mices, body weight 20g ± 1g, male and female half and half are divided into 4 groups at random.High and low two dosage of pill administration component of the present invention, 1g, 2 times on the 1st, continuous 6 days; Positive controls, 1g, XIAOYIN PIAN liquid, 2 times on the 1st, continuous 6 days; The blank group, 1g is with the volume distilled water.Pill administration group of the present invention and positive drug control group be 1.5h behind the last medicine all, and 0.03ml dimethylbenzene is dripped in the right side auricle; The left side auricle is contrast, drips a back 30min and puts to death mice, cuts auricle, sweep away auricle with diameter 9mm card punch in left and right sides ear same area to weigh, about two auricle weight differences be the swelling value, the result carries out t and checks, and sees Table 4.Table 4 is the result show, the administration group mice auricle swelling value equal significance of comparing with matched group, and pill xylol of the present invention causes auricle edema significant inhibitory effect.
5, to the influence of rat skin capillary permeability: get 40 of rats, body weight 211 ± 29g, the male and female dual-purpose is divided into 4 groups at random.Two dosage of pill administration component height of the present invention; Positive drug control group gives the XIAOYIN PIAN aqueous solution; The blank group is given with the volume distilled water.Each is organized equal 1g and gives rat, once-a-day, and continuous 6 days.2h ventrimeson both sides intradermal injection contains the normal saline solution 0.1ml of the 100ug of histamine behind the last medicine, femoral vein injects 1% according to the blue 1ml/kg of the train of thought immediately, rat is put to death in dislocation after 30 minutes, peel off skin of abdomen, indigo plant is dyed the skin chopping put into 9ml acetone: normal saline (7: 3) solution soaks 24h, centrifugal back colorimetric (610nm).The results are shown in Table 5.Table 5 is the result show, the administration group is according to the seepage discharge of train of thought orchid and blank group significance relatively, point out pill of the present invention significantly to suppress rat skin capillary permeability enhancing due to the histamine, makes according to train of thought orchid and oozes out minimizing.
6, to the influence of Cavia porcellus allergic asthma: through screening 32 of qualified Cavia porcelluss, body weight 305 ± 42g, male and female dual-purpose.The experiment glass box, its top passage connects the aerosol apparatus that contains histamine's liquid, and through the passage compressible air, the other plastic tube of pacifying a diameter 4mm in addition of aerosol apparatus inserts in the glass box and communicates with atmosphere.Cavia porcellus is divided into 4 groups at random, pill high and low dose group of the present invention, XIAOYIN PIAN positive controls, blank group, 8 every group, with aerosol apparatus 0.3% histamine phosphate is sprayed in the case, pressure is 400mmHg, spray time 15S.After Cavia porcellus sucks histamine, can produce asthma reaction through certain incubation period, its program is divided into level Four.One-level is quickened for breathing; Secondary is a dyspnea; Three grades for twitching; Level Four is for rolling.The previous day is selected animal in experiment, selects for use to produce the animal that (twitches or roll) more than three grades in the 3.5min after the spraying histamine and test, and writes down the incubation period that third-order reaction appears in every animal.Next day, press table 6 dosage 1g administration, spraying in 4 hours sucks histamine behind medicine, observes 6min, and the number of animals and the incubation period of fourth-order reaction appear in record.Surpass 6min person incubation period then it draws and breathes heavily incubation period in 6min if draw to breathe heavily.Subtract that be the prolongation value incubation period before the medicine incubation period behind the medicine, and each is organized the prolongation of latency value and does the t check, the results are shown in Table 6.Table 6 result learns by statistics to handle and shows, preclinical prolongation value of each administration group asthma reaction and blank group be significance relatively all, table 6 is the result also show, obviously be longer than incubation period (paired t-test, P＜0.01) before the medicine incubation period of asthma reaction behind the administration group medicine.
7, the influence that the Cavia porcellus anaphylactic shock is reacted: 32 of Cavia porcelluss, body weight 281 ± 52g, the male and female dual-purpose is divided into 4 groups at random.The XIAOYIN PIAN positive controls, the blank group, pill high and low dose group of the present invention, send out quick two the week before every Cavia porcellus iP, 1: 10 Ox blood serum 0.1ml makes its sensitization.Every day is 1g pill 2.0g/kg of the present invention, 6.0g/kg on an empty stomach; XIAOYIN PIAN 4.0g/kg, in two weeks of successive administration, every the Cavia porcellus veins in two week backs inject Ox blood serum stock solution 1.5ml, occur that arbitrary to send out symptom quick be that opening entry is sent out quick time and death time.Send out symptom quick dysphoria, perpendicular hair are arranged, grab nose, sneeze, cough, gatism, spasm, serious shock, death.The results are shown in Table 7.Carry out mathematical statistics with the t check between each group.The result shows, the time that the equal deferrable allergy symptoms of administration group occurs, after symptom occurred, pill high dose group of the present invention had retardation function than matched group to the death time.
[conclusion (of pressure testing)]
Two kinds of psoriasis animal models have been selected in this test for use: with the parakeratosis of the main pathological characteristic of Mus tail scale epidermis modeling psoriasis; Mouse vagina epithelium division with the female androsin cycle increases, the cell conversion is accelerated the hyperplasia of simulation psoriasis epidermis, substituted the characteristics of accelerating, and pill of the present invention all shows curative effect preferably on these two kinds of models.Psoriasis disease is seen general of erythra, and substrate takes on a red color, and pruritus has selected for use the swollen histamine that reaches of mice caused by dimethylbenzene xylene ear to cause two kinds of antiinflammatory indexs of rat skin capillary permeability enhancing, and pill of the present invention all shows antiinflammatory action preferably.Pill of the present invention can also improve the lymphocytic percentage ratio of blood T, strengthens cellular immune function.The effect that has anti-Cavia porcellus I allergic reaction type simultaneously.
Table 1 pill of the present invention is to the mitotic influence of mouse vagina epithelial cell
The other t check of dosage number of animals mitosis fat array
(g/kg), (only), (blank 10 21.358 ± 2.239 of X ± SD): * * pill low dosage 3.0 10 7.151 ± 1.432 * of the present invention: * pill high dose 6.0 10 5.25 ± 1.509 * of the present invention+: XIAOYIN PIAN 3.0 10 8.924 ± 2.164 *+*
Remarks :-P＞0.05+P＜0.05 * P＜0.01: reference group.
Table 2 pill of the present invention is to there being the influence of the scale number of granular layer in per 100 scales of mouse tail scale epidermis
Dosage number of animals group X ± SD t check
(g/kg), (only) blank 10 9.26 ± 2.041: * * pill low dosage 3.0 10 21.608 ± 1.053 * of the present invention: * pill high dose 6.0 10 29.125 ± 1.751 * * of the present invention: XIAOYIN PIAN 3.0 10 17.997 ± 2.718 * * *
Remarks :-P＞0.05+P＜0.05 * P＜0.01: reference group.
Table 3 pill of the present invention is to the influence of mouse blood T lymphocyte percentage ratio
Dosage number of animals X ± SD group t check
(g/kg), (only), (%) blank 10 14.365 ± 3.245: * * pill low dosage 3.0 10 26.994 ± 5.269 * of the present invention: * pill high dose 6.0 10 51.43 ± 20.551 * * of the present invention: XIAOYIN PIAN 3.0 10 23.221 ± 6.609 *-*
Remarks :-P＞0.05+P＜0.05 * P＜0.01: reference group.
Table 4 pill of the present invention is to the bullate influence of Mice Auricle caused by dimethylbenzene xylene
Dosage number of animals group swelling value t check
(g/kg), (only) blank 10 21.64 ± 3.32 :+* pill low dosage 3.0 10 15.94 ± 5.79 of the present invention+:-pill high dose 6.0 10 12.79 ± 3.62 * of the present invention-: XIAOYIN PIAN 3.0 10 18.35 ± 2.19+-*
Remarks :-P＞0.05+P＜0.05 * P＜0.01: reference group.
Table 5 pill of the present invention is to the influence of rat skin capillary permeability
Dosage number of animals dye levels group t check
(g/kg) (only) (blank 10 0.3031 ± 0.0818 of OD.X ± SD): * * pill low dosage 2.0 10 0.1789 of the present invention ± 0.040 7 * :-pill high dose 4.0 10 0.1763 ± 0.0494 * of the present invention-: XIAOYIN PIAN 4.0 10 0.1576 ± 0.0649 *--
Remarks :-P＞0.05+P＜0.05 * P＜0.01: reference group.
Table 6 pill of the present invention is to the preclinical influence of Guinea Pig Histamine asthma attack
Prolongation of latency value group number of animals P value behind third-order reaction medicine preceding incubation period of the medicine behind the dosage number of animals medicine
(g/kg), (only), (only), (min X ± SD), (min X ± SD), (blank 88 2.19 ± 0.53 1.39 ± 0.43-0.65 ± 0.28 of min X ± SD): pill low dosage 2.0 88 2.20 of the present invention ± 0.83 3.88 ± 1.21 1.54 ± 0.96 * pill high dose 4.0 88 1.93 of the present invention ± 0.72 3.81 ± 1.73 1.88 ± 1.34 * XIAOYIN PIAN 4.0 88 2.10 ± 0.72 3.92 ± 1.46 1.82 ± 1.54 *
Remarks :-P＞0.05 * P＜0.01: reference group.
Table 7 pill of the present invention is to the influence of Cavia porcellus anaphylactic shock
Dosage number of animals symptom time of occurrence death time group the symptom number of elements occurs dead number of elements takes place
(g/kg) (only) ((blank 885 56 ± 23 150 ± 77 pill low dosage 2.0 882 203 of the present invention ± 150 195 ± 64 pill high doses 6.0 884 217 of the present invention ± 161 311 ± 54 XIAOYIN PIAN group 4.0 883 157 ± 112 255 ± 148 of S X ± SD) of S X ± SD)
Remarks :-P＞0.05+P＜0.05: reference group.
The present invention compares with existing Chinese patent medicine and has the following advantages and effect:
1, from the pharmacology analysis of main formula, this medicine is from clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling, blood enriching and dryness moistening, therefore dispelling wind is antipruritic starts with, and not to the utmost " wind heat blood-dryness type " psoriasis is had definite curative effect, and " blood-deficiency and wind-dry type " reach " stasis of blood stagnate skin type " psoriasis the curative effect of being satisfied with is especially also arranged.
2, prove that from pharmacodynamic experiment this medication effect obviously is better than the matched group XIAOYIN PIAN, little by animal acute toxicity test and long term toxicity test proof toxicity, have no side effect.
3, carried out 10 months clinical observation by a definite date, observed patient's 400 examples altogether, 300 examples are organized in treatment, XIAOYIN PIAN reference group 100 examples, and XIAOYIN PIAN matched group total effective rate is 82%.Total effective rate of the present invention is 90.67%.
Further specify technical solution of the present invention in conjunction with most preferred embodiment.
1, takes by weighing Radix Angelicae Sinensis 146 grams, Herba Schizonepetae 126 grams, rhizoma sparganic 78 grams, Rhizoma Curcumae 78 gram mix homogeneously, carry out distillating extracting oil.
2, get Radix Sophorae Flavescentis 213 grams, Radix Paeoniae Rubra 146 grams, Cortex Dictamni 146 grams, Radix Rehmanniae 78 grams, Radix Scrophulariae 78 grams, Periostracum Cicadae 78 gram mix homogeneously, the back adds the volatile oil medicinal residues, decoct with water 2 times, and 2 hours for the first time, 1 hour for the second time, merge the secondary decocting liquid, filter.
3, the relative density that volatile oil and decocting liquid are concentrated respectively is 1.25～1.30 thick paste.
4, get Radix Salviae Miltiorrhizae 213 grams, Flos Carthami 146 grams, Cortex Moutan 146 grams, Radix Polygoni Multiflori 146 grams, Flos Lonicerae 126 gram mix homogeneously, be ground into fine powder.
5, the volatile oil thick paste is dissolved in ethanol and sprays in the fine powder, close with decocting liquid thick paste again and all make the 1000 gram watered pills, drying, the sugar coating polishing is promptly.
Claims (1)
1, a kind of medicine for psoriasis, it is characterized in that: select Chinese herbal medicine Radix Sophorae Flavescentis 213 grams for use, Radix Salviae Miltiorrhizae 213 grams, Flos Carthami, Radix Paeoniae Rubra, Cortex Moutan, Radix Angelicae Sinensis, Radix Polygoni Multiflori, each 146 gram of Cortex Dictamni, Herba Schizonepetae, each 126 gram of Flos Lonicerae, Rhizoma Curcumae, rhizoma sparganic, Radix Rehmanniae, Radix Scrophulariae, each 78 gram of Periostracum Cicadae, extract Radix Angelicae Sinensis, Herba Schizonepetae, rhizoma sparganic, the volatile oil and the Radix Sophorae Flavescentis of Rhizoma Curcumae mixing medical material, Radix Paeoniae Rubra, Cortex Dictamni, Radix Rehmanniae, Radix Scrophulariae, Periostracum Cicadae mixes medical material decocting liquid, the two is concentrated into relative density respectively is 1.25～1.30 thick paste, Radix Salviae Miltiorrhizae, Flos Carthami, Cortex Moutan, Radix Polygoni Multiflori, Flos Lonicerae mixes pulverizing medicinal materials and becomes fine powder, the volatile oil thick paste is dissolved in ethanol sprays in the fine powder, close even pill with decocting liquid thick paste again and form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96121234A CN1049350C (en) | 1996-11-15 | 1996-11-15 | Medicine for psoriasis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN96121234A CN1049350C (en) | 1996-11-15 | 1996-11-15 | Medicine for psoriasis |
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| CN1049350C true CN1049350C (en) | 2000-02-16 |
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| CN96121234A Expired - Lifetime CN1049350C (en) | 1996-11-15 | 1996-11-15 | Medicine for psoriasis |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1332702C (en) * | 2005-04-25 | 2007-08-22 | 王宪珍 | Medicine for treating psoriasis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066059C (en) * | 1998-05-20 | 2001-05-23 | 王嗣桐 | Psoriasis paster |
| CN100337646C (en) * | 2003-11-26 | 2007-09-19 | 许力法 | Chinese traditional medicine for treating psoriasis and cutaneous pruritus |
| CN100522137C (en) * | 2007-02-16 | 2009-08-05 | 遵义医学院附属医院 | Cream for treating psoriasis and its preparing process |
| CN102343052B (en) * | 2011-10-12 | 2013-06-12 | 董洪海 | Traditional Chinese medicine for psoriasis |
| CN104189822A (en) * | 2014-08-25 | 2014-12-10 | 河南科技大学第一附属医院 | Psoriasis coating paste and preparation method thereof |
| CN109045247A (en) * | 2018-10-27 | 2018-12-21 | 湖南慧好生物医药科技有限公司 | A kind of dendrobium candidum compound preparation and preparation method thereof and purposes |
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1996
- 1996-11-15 CN CN96121234A patent/CN1049350C/en not_active Expired - Lifetime
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| CN1162473A (en) | 1997-10-22 |
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