CN104920442A - Deltamethrin water-dispersible floating tablet and preparation method therefor - Google Patents
Deltamethrin water-dispersible floating tablet and preparation method therefor Download PDFInfo
- Publication number
- CN104920442A CN104920442A CN201510169820.8A CN201510169820A CN104920442A CN 104920442 A CN104920442 A CN 104920442A CN 201510169820 A CN201510169820 A CN 201510169820A CN 104920442 A CN104920442 A CN 104920442A
- Authority
- CN
- China
- Prior art keywords
- water
- floating tablet
- deltamethrin
- decis
- aqueous dispersion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 title claims abstract description 47
- 238000007667 floating Methods 0.000 title claims abstract description 34
- 239000005892 Deltamethrin Substances 0.000 title claims abstract description 16
- 229960002483 decamethrin Drugs 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 239000000843 powder Substances 0.000 claims abstract description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 238000009736 wetting Methods 0.000 claims abstract description 11
- 239000002270 dispersing agent Substances 0.000 claims abstract description 8
- 239000007884 disintegrant Substances 0.000 claims abstract description 7
- 239000006185 dispersion Substances 0.000 claims description 28
- 239000003814 drug Substances 0.000 claims description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 13
- 229920002472 Starch Polymers 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 239000008107 starch Substances 0.000 claims description 9
- 235000019698 starch Nutrition 0.000 claims description 9
- 240000001980 Cucurbita pepo Species 0.000 claims description 8
- 235000009852 Cucurbita pepo Nutrition 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- -1 polyoxyethylene formaldehyde Polymers 0.000 claims description 8
- 235000009854 Cucurbita moschata Nutrition 0.000 claims description 7
- 238000005469 granulation Methods 0.000 claims description 7
- 230000003179 granulation Effects 0.000 claims description 7
- 239000011122 softwood Substances 0.000 claims description 7
- 235000020354 squash Nutrition 0.000 claims description 7
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- 239000012190 activator Substances 0.000 claims description 6
- 239000011230 binding agent Substances 0.000 claims description 6
- 239000007844 bleaching agent Substances 0.000 claims description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 5
- 239000000440 bentonite Substances 0.000 claims description 5
- 229910000278 bentonite Inorganic materials 0.000 claims description 5
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 4
- 229960000892 attapulgite Drugs 0.000 claims description 4
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
- 229910052625 palygorskite Inorganic materials 0.000 claims description 4
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- 150000003871 sulfonates Chemical class 0.000 claims description 4
- 239000005995 Aluminium silicate Substances 0.000 claims description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 3
- 235000012211 aluminium silicate Nutrition 0.000 claims description 3
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 3
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 229920005610 lignin Polymers 0.000 claims description 3
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 3
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims description 3
- 239000008108 microcrystalline cellulose Substances 0.000 claims description 3
- 229940088417 precipitated calcium carbonate Drugs 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 2
- SQAINHDHICKHLX-UHFFFAOYSA-N 1-naphthaldehyde Chemical class C1=CC=C2C(C=O)=CC=CC2=C1 SQAINHDHICKHLX-UHFFFAOYSA-N 0.000 claims description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 229920001732 Lignosulfonate Polymers 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims description 2
- 235000012216 bentonite Nutrition 0.000 claims description 2
- BEHLMOQXOSLGHN-UHFFFAOYSA-N benzenamine sulfate Chemical compound OS(=O)(=O)NC1=CC=CC=C1 BEHLMOQXOSLGHN-UHFFFAOYSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- UDHMTPILEWBIQI-UHFFFAOYSA-N butyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(=O)OCCCC)=CC=CC2=C1 UDHMTPILEWBIQI-UHFFFAOYSA-N 0.000 claims description 2
- 239000001110 calcium chloride Substances 0.000 claims description 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 2
- 239000004202 carbamide Substances 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 239000007859 condensation product Substances 0.000 claims description 2
- 150000002190 fatty acyls Chemical group 0.000 claims description 2
- DNIKXCUKOGVNIO-UHFFFAOYSA-N formaldehyde;phenol;styrene Chemical compound O=C.OC1=CC=CC=C1.C=CC1=CC=CC=C1 DNIKXCUKOGVNIO-UHFFFAOYSA-N 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- 229920001568 phenolic resin Polymers 0.000 claims description 2
- 125000002467 phosphate group Chemical class [H]OP(=O)(O[H])O[*] 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 239000000661 sodium alginate Substances 0.000 claims description 2
- 235000010413 sodium alginate Nutrition 0.000 claims description 2
- 229940005550 sodium alginate Drugs 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 229910021653 sulphate ion Inorganic materials 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 240000007594 Oryza sativa Species 0.000 abstract description 2
- 235000007164 Oryza sativa Nutrition 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 235000009566 rice Nutrition 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 1
- 230000001070 adhesive effect Effects 0.000 abstract 1
- 238000004061 bleaching Methods 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 239000004495 emulsifiable concentrate Substances 0.000 abstract 1
- 239000000945 filler Substances 0.000 abstract 1
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000007779 soft material Substances 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000011835 investigation Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 241000500437 Plutella xylostella Species 0.000 description 4
- 235000013311 vegetables Nutrition 0.000 description 4
- 235000006008 Brassica napus var napus Nutrition 0.000 description 3
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 3
- 241001674939 Caulanthus Species 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 244000144730 Amygdalus persica Species 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 244000003416 Asparagus officinalis Species 0.000 description 1
- 235000005340 Asparagus officinalis Nutrition 0.000 description 1
- 235000016068 Berberis vulgaris Nutrition 0.000 description 1
- 241000335053 Beta vulgaris Species 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- 235000009024 Ceanothus sanguineus Nutrition 0.000 description 1
- 235000007516 Chrysanthemum Nutrition 0.000 description 1
- 244000189548 Chrysanthemum x morifolium Species 0.000 description 1
- 241001414720 Cicadellidae Species 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- YVGGHNCTFXOJCH-UHFFFAOYSA-N DDT Chemical compound C1=CC(Cl)=CC=C1C(C(Cl)(Cl)Cl)C1=CC=C(Cl)C=C1 YVGGHNCTFXOJCH-UHFFFAOYSA-N 0.000 description 1
- 235000011511 Diospyros Nutrition 0.000 description 1
- 244000236655 Diospyros kaki Species 0.000 description 1
- 241000255925 Diptera Species 0.000 description 1
- 241001517923 Douglasiidae Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000219146 Gossypium Species 0.000 description 1
- 241000578422 Graphosoma lineatum Species 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 241000510199 Helicoverpa assulta Species 0.000 description 1
- 241000255967 Helicoverpa zea Species 0.000 description 1
- 241000258937 Hemiptera Species 0.000 description 1
- 241000255777 Lepidoptera Species 0.000 description 1
- 240000003553 Leptospermum scoparium Species 0.000 description 1
- 235000004431 Linum usitatissimum Nutrition 0.000 description 1
- 240000006240 Linum usitatissimum Species 0.000 description 1
- 241000254022 Locusta migratoria Species 0.000 description 1
- 235000015459 Lycium barbarum Nutrition 0.000 description 1
- 239000005949 Malathion Substances 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 235000011430 Malus pumila Nutrition 0.000 description 1
- 235000015103 Malus silvestris Nutrition 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 241000409991 Mythimna separata Species 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 241000238814 Orthoptera Species 0.000 description 1
- 241000721451 Pectinophora gossypiella Species 0.000 description 1
- 241000255969 Pieris brassicae Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 240000000111 Saccharum officinarum Species 0.000 description 1
- 235000007201 Saccharum officinarum Nutrition 0.000 description 1
- 244000046109 Sorghum vulgare var. nervosum Species 0.000 description 1
- 241000985245 Spodoptera litura Species 0.000 description 1
- 241001414989 Thysanoptera Species 0.000 description 1
- 241000425037 Toona sinensis Species 0.000 description 1
- 241000219793 Trifolium Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 240000008866 Ziziphus nummularia Species 0.000 description 1
- 230000000895 acaricidal effect Effects 0.000 description 1
- 239000000642 acaricide Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- CVXBEEMKQHEXEN-UHFFFAOYSA-N carbaryl Chemical compound C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 CVXBEEMKQHEXEN-UHFFFAOYSA-N 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- JXSJBGJIGXNWCI-UHFFFAOYSA-N diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate Chemical compound CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC JXSJBGJIGXNWCI-UHFFFAOYSA-N 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000000749 insecticidal effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229960000453 malathion Drugs 0.000 description 1
- LCCNCVORNKJIRZ-UHFFFAOYSA-N parathion Chemical compound CCOP(=S)(OCC)OC1=CC=C([N+]([O-])=O)C=C1 LCCNCVORNKJIRZ-UHFFFAOYSA-N 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002940 repellent Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000004894 snout Anatomy 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention discloses a deltamethrin water-dispersible floating tablet. The deltamethrin water-dispersible floating tablet comprises the following component raw materials in percentages by weight: 1-25% of deltamethrin, 0.1-30% of wetting and dispersing agent, 1-30% of co-disintegrant, 0.1-20% of adhesive, 0.1-15% of bleaching assistant, 0.1-30% of flow control agent and the balance of filler carrier. The invention also discloses a preparation method of the deltamethrin water-dispersible floating tablet. The preparation method comprises the following steps: preparing the component raw materials into dry powder with certain fineness, adding water to prepare a soft material, extruding, granulating, drying, and finally tabletting to obtain the deltamethrin water-dispersible floating tablet. The tablet can overcome the defect of high use and processing cost in traditional preparation emulsifiable concentrate solvents. When in use, the water-dispersible floating tablet can be directly added into a water-containing sprayer, and the deltamethrin is uniformly dispersed in water due to high disintegration rate; and the deltamethrin solution can be sprayed to various crops or directly thrown and sprayed to rice paddy fields, so that the tablet is convenient to use. The deltamethrin water-dispersible floating tablet is small in size, extremely convenient to transport and store, environment-friendly, low in cost and convenient for industrial production.
Description
Technical field
The present invention relates to formulations of pesticide manufacture field, floating tablet of aqueous dispersion being specifically related to a kind of decis and preparation method thereof.
Background technology
Decis, has another name called " decis ", is the one that in chrysanthemum ester insecticide, virulence is the highest, can reach 100 times of dichlorodiphenyl trichloroethane to the toxic effect of insect, 80 times of sevin, 550 times of malathion, 40 times of parathion.Have and tag and stomach poison function, action of contace poison is rapid, and power of knocking down is strong, and not stifling and systemic action, has repellent action to some insects in higher concentrations.Being mixed with missible oil or wetting powder, is medium insecticide.Insecticidal spectrum is wide, effective to various pests such as Lepidoptera, orthoptera, thrips, Semiptera, diptera, coleopteras, but very low or substantially invalid to preventive effects such as mite class, scale insect, mirid pentatomids, mite class also can be stimulated to breed, when worm mite is concurrent, mixed with specialized acaricide.
Decis applicable crops widely, can be widely used in the various plants such as brassicaceous vegetable, gourd vegetables, leguminous vegetables, solanaceous vegetables, asparagus, paddy rice, wheat, corn, Chinese sorghum, rape, peanut, soybean, beet, sugarcane, flax, sunflower, clover, cotton, tobacco, tea tree, apple, pears, peach, Lee, jujube, persimmon, grape, chestnut, oranges and tangerines, banana, lichee, Du Guo, forest, flowers, Chinese herbal medicine, meadow.To various pests such as cotton bollworm, pink bollworm, cabbage caterpillar, diamond-back moth, prodenia litura, oriental tobacco budworm, the chrysomelid insects of food, Phytophthira, blind Chinese toon class, stinkbug class, leafhopper class, heart-eating worm class, leaf miner class, slug moth class, caterpillar class, looper class, bridging insects, mythimna separata class, snout moth's larva class, locustamigratorias, all there is good killing effect.Decis is mainly used in pest control of spraying, and sometimes also can mix soil as required and spread fertilizer over the fields.
The main formulation of existing decis is missible oil and wetting powder.Through retrieval, decis is made the floating tablet of aqueous dispersion and application thereof and there is no people's report.
Summary of the invention
The object of the present invention is to provide a kind of high-load, environmental protection, availability is high, and can at the floating tablet of decis aqueous dispersion of water float rapid dispersion uniformly suspension, to improve exist in prior art environmental pollution, be detrimental to health and the shortcoming such as use cost is high.
The technical solution used in the present invention is as follows:
The floating tablet of aqueous dispersion of decis, the percentage by weight of each component is: decis 1-25%, wetting dispersing agent 0.1-30%, help disintegrant 1-30%, binding agent 0.1-20%, bleach activator 0.1-15%, flowing regulator 0.1-30%, surplus is filling carrier.
Described wetting dispersing agent is selected from two or more of following composition: lauryl sodium sulfate, neopelex, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, sodium butylnaphthalenesulfonate, styrene phenol formaldehyde resin polyoxyethylene ether phosphate salt, styryl phenol polyethenoxy polyethenoxy ether, alkyl naphthalene formaldehyde condensate sulfonates, dialkyl succinylsuccinate sulfonated ester, naphthalene formaldehyde condensate sulfonates, lignin, lignosulfonates, to methoxyl group fatty acyl anilinesulfonic acid, polycarboxylic acid salt.
The described disintegrant that helps is selected from: the one in ammonium sulfate, white carbon, anhydrous sodium sulfate, sodium chloride, calcium chloride, bentonite, sodium alginate, sodium carboxymethyl starch, microcrystalline cellulose, crospolyvinylpyrrolidone, Ac-Di-Sol.
Described binding agent is selected from: the one in carboxymethyl cellulose, polyvinylpyrrolidone, hydroxypropyl methylcellulose, polyethylene glycol, starch, sucrose, polyvinyl alcohol, Sodium Polyacrylate, dextrin, lactose.
Described bleach activator is selected from: the one in octadecyl alcolol, white carbon, attapulgite, diatomite, sodium bicarbonate.
Described flowing regulator is selected from: the one in talcum powder, stearate, white carbon.
Described filling carrier is selected from: the one in glucose, precipitated calcium carbonate, anhydrous sodium sulfate, kaolin, bentonite, attapulgite, modified soluble starch, white carbon, urea.
The preparation method of the floating tablet of described decis aqueous dispersion comprises the steps:
(1) by deltamethrin original medicine, wetting dispersing agent, help disintegrant, binding agent, bleach activator, filling carrier to mix, after coarse crushing, then through airslide disintegrating mill pulverize, make the material of 99% by 325 mesh standard sieves, obtain certain fineness dry powder.
(2) add suitable quantity of water and make softwood, carry out granulation with squash type comminutor, under the condition of about 50 DEG C, be dried to particle water content be less than 3%, screening, particle size range about 2000 μm.
(3) add flowing regulator, fully mix, tabletting machine, obtain the floating tablet of decis aqueous dispersion.
Advantage of the present invention: decis is made the floating tablet of aqueous dispersion, can avoid the use of conventional formulation missible oil solvent and the high shortcoming of processing cost.Directly can drop in the sprayer be filled with water by floating for aqueous dispersion tablet during use, can be distributed in water equably owing to playing the very fast decis of drift disintegration, spray application, in various crop, also directly can be thrown and execute in paddy field, easy to use.Volume of the present invention is little, transports and stores easily, and environmentally friendly, with low cost, is convenient to suitability for industrialized production.
Embodiment
Embodiment 1:
Take deltamethrin original medicine 6%, neopelex 2%, lignin 6%, sodium carboxymethyl starch 6%, hydroxypropyl methylcellulose 8%, white carbon 10%, kaolin complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 50 DEG C of conditions, finally adds talcum powder 2%, after mixing; namely obtain the floating tablet of aqueous dispersion by tabletting machine, the large I of tablet is determined as required.
Embodiment 2:
Take deltamethrin original medicine 8%, lauryl sodium sulfate 1.5%, NNO6%, microcrystalline cellulose 12%, dextrin 6%, octadecyl alcolol 8%, modified soluble starch complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 50 DEG C of conditions, finally adds white carbon 2%, after mixing; namely obtain the floating tablet of aqueous dispersion by tabletting machine, the large I of tablet is determined as required.
Embodiment 3:
Take deltamethrin original medicine 10%, pull open powder 2%, D4255%, ammonium sulfate 10%, hydroxypropyl methylcellulose 6%, white carbon 12%, bentonite complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 50 DEG C of conditions, finally adds dolomol 2%, after mixing; namely obtain the floating tablet of aqueous dispersion by tabletting machine, the large I of tablet is determined as required.
Embodiment 4:
Take deltamethrin original medicine 12%, NP-101.5%, SP-27005%, crospolyvinylpyrrolidone 4%, lactose 8%, octadecyl alcolol 10%, modified soluble starch complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 50 DEG C of conditions, finally adds talcum powder 2.5%, after mixing; namely obtain the floating tablet of aqueous dispersion by tabletting machine, the large I of tablet is determined as required.
Embodiment 5:
Take deltamethrin original medicine 14%, lauryl sodium sulfate 2%, dispersant 28006%, anhydrous sodium sulfate 10%, hydroxypropyl methylcellulose 8%, sodium bicarbonate 5%, precipitated calcium carbonate complements to 100%.Mixed; after coarse crushing; pulverize through airslide disintegrating mill and obtain female powder, 99% female powder by 325 mesh sieves, then adds suitable quantity of water and makes softwood; with squash type comminutor by female powder granulation; particle is dried to water content and is less than 3% under 50 DEG C of conditions, finally adds dolomol 2.5%, after mixing; namely obtain the floating tablet of aqueous dispersion by tabletting machine, the large I of tablet is determined as required.
Field control effectiveness test
1 medicament
The floating tablet of 1.1 test medicine 20% decis aqueous dispersion
1.2 contrast medicament 20% decis wetting powders
1.3 reagent agent experimental scheme
Table 1 reagent agent experimental scheme
1.4 plot area and replicated plot area: 20m2, number of repetition: 4 times
2 application methods
2.1 using method
First each treatment agent is weighed before test and matches, first spray blank district clear water by special messenger, then from low dosage to high dose treatment region successively even spraying each treatment region liquid.
2.2 spraying times and number of times contain a phase dispenser once according to design dosage at wild cabbage diamondback moth larvae on June 13rd, 2014.
3 crop investigation
Investigate insect population radix before 3.1 control times and number of times dispenser, after medicine, 3 days (June 16) and 7 days (June 20) investigate residual borer population of living respectively.
3.2 investigation method
Investigation employing five point sampling, 5 points are got in every community, and each some investigation 4 strain, Ji Mei investigates community 20 strains.According to the residual borer population of living of the insect population cardinal sum of investigation, calculate the control efficiency of each chemicals treatment.
3.3 do not find poisoning phenomenon to direct the impact in process of the test of crop, and each chemicals treatment all shows higher safety.
4 results and analysis application DPS data handling systems carry out variance analysis, use Duncan duncan's new multiple range method to carry out significant difference analysis.
The floating tablet of table 220% decis aqueous dispersion and 20% decis wetting powder control wild cabbage diamond-back moth field control effectiveness test result
Result of the test shows, the floating tablet of 20% decis aqueous dispersion has good control efficiency to wild cabbage diamond-back moth, per hectare this medicament 15g, 20g, 30g, and after medicine, 3d preventive effect is 64.46%-85.12%, and after medicine, 7d preventive effect is 80.69%-97.35%; 3d and 7d after medicine, the floating tablet 30g/hm of 20% decis aqueous dispersion
2preventive effect is apparently higher than contrast medicament 16.5g/hm
2preventive effect, and there is significant difference.
Claims (8)
1. the floating tablet of the aqueous dispersion of decis, is characterized in that: the percentage by weight of each component is: decis 1-25%, wetting dispersing agent 0.1-30%, help disintegrant 1-30%, binding agent 0.1-20%, bleach activator 0.1-15%, flowing regulator 0.1-30%, surplus is filling carrier.
2. the floating tablet of aqueous dispersion of a kind of decis according to claim 1, it is characterized in that: described wetting dispersing agent is selected from two or more of following composition: lauryl sodium sulfate, neopelex, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, sodium butylnaphthalenesulfonate, styrene phenol formaldehyde resin polyoxyethylene ether phosphate salt, styryl phenol polyethenoxy polyethenoxy ether, alkyl naphthalene formaldehyde condensate sulfonates, dialkyl succinylsuccinate sulfonated ester, naphthalene formaldehyde condensate sulfonates, lignin, lignosulfonates, to methoxyl group fatty acyl anilinesulfonic acid, polycarboxylic acid salt.
3. the floating tablet of aqueous dispersion of a kind of decis according to claim 1, is characterized in that: the described disintegrant that helps is selected from: the one in ammonium sulfate, white carbon, anhydrous sodium sulfate, sodium chloride, calcium chloride, bentonite, sodium alginate, sodium carboxymethyl starch, microcrystalline cellulose, crospolyvinylpyrrolidone, Ac-Di-Sol.
4. the floating tablet of aqueous dispersion of a kind of decis according to claim 1, is characterized in that: described binding agent is selected from: the one in carboxymethyl cellulose, polyvinylpyrrolidone, hydroxypropyl methylcellulose, polyethylene glycol, starch, sucrose, polyvinyl alcohol, Sodium Polyacrylate, dextrin, lactose.
5. the floating tablet of aqueous dispersion of a kind of decis according to claim 1, is characterized in that: described bleach activator is selected from: the one in octadecyl alcolol, white carbon, attapulgite, diatomite, sodium bicarbonate.
6. the floating tablet of aqueous dispersion of a kind of decis according to claim 1, is characterized in that: described flowing regulator is selected from: the one in talcum powder, stearate, white carbon.
7. the floating tablet of aqueous dispersion of a kind of decis according to claim 1, is characterized in that: described filling carrier is selected from: the one in glucose, precipitated calcium carbonate, anhydrous sodium sulfate, kaolin, bentonite, attapulgite, modified soluble starch, white carbon, urea.
8. the preparation method of the floating tablet of aqueous dispersion of a kind of decis according to claim 1, is characterized in that, comprise the steps:
(1) by deltamethrin original medicine, wetting dispersing agent, help disintegrant, binding agent, bleach activator, filling carrier to mix, after coarse crushing, then through airslide disintegrating mill pulverize, make the material of 99% by 325 mesh standard sieves, obtain certain fineness dry powder.
(2) add suitable quantity of water and make softwood, carry out granulation with squash type comminutor, under the condition of about 50 DEG C, be dried to particle water content be less than 3%, screening, particle size range about 2000 μm.
(3) add flowing regulator, fully mix, tabletting machine, obtain the floating tablet of decis aqueous dispersion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510169820.8A CN104920442A (en) | 2015-04-10 | 2015-04-10 | Deltamethrin water-dispersible floating tablet and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510169820.8A CN104920442A (en) | 2015-04-10 | 2015-04-10 | Deltamethrin water-dispersible floating tablet and preparation method therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104920442A true CN104920442A (en) | 2015-09-23 |
Family
ID=54108156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510169820.8A Pending CN104920442A (en) | 2015-04-10 | 2015-04-10 | Deltamethrin water-dispersible floating tablet and preparation method therefor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104920442A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109862790A (en) * | 2016-09-08 | 2019-06-07 | 海怡弥私人有限公司 | Water-soluble controlled release composition and preparation method thereof and application method |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0415688A2 (en) * | 1989-08-30 | 1991-03-06 | Aeci Ltd | Dosage device and preparation and use thereof |
| CN1268024A (en) * | 1997-08-22 | 2000-09-27 | 基诺农业化学(专有)有限公司 | Dosage device |
| CN1887090A (en) * | 2005-06-28 | 2007-01-03 | 张宗俭 | Water dispersed tablet of pyrethroid pesticide and its prepn |
-
2015
- 2015-04-10 CN CN201510169820.8A patent/CN104920442A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0415688A2 (en) * | 1989-08-30 | 1991-03-06 | Aeci Ltd | Dosage device and preparation and use thereof |
| CN1268024A (en) * | 1997-08-22 | 2000-09-27 | 基诺农业化学(专有)有限公司 | Dosage device |
| CN1887090A (en) * | 2005-06-28 | 2007-01-03 | 张宗俭 | Water dispersed tablet of pyrethroid pesticide and its prepn |
Non-Patent Citations (1)
| Title |
|---|
| 王勇 等: "农药新剂型——水分散片剂", 《农药》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109862790A (en) * | 2016-09-08 | 2019-06-07 | 海怡弥私人有限公司 | Water-soluble controlled release composition and preparation method thereof and application method |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104026143B (en) | Binary pesticide composition and uses thereof | |
| CN104663702A (en) | Insecticidal and acaricidal composition containing esbiothrin insecticide | |
| CN102835414A (en) | Composition containing sulfoxaflor and amide pesticides | |
| CN104663692A (en) | Insecticidal and acaricidal composition containing insect growth regulator insecticide | |
| CN104351189B (en) | Binary pesticide composition and uses thereof | |
| CN103125493A (en) | Insecticide composition mixed with amides pesticide | |
| CN104585224A (en) | Pesticide composition containing fluensulfone and pyrethroid insecticide | |
| CN104920442A (en) | Deltamethrin water-dispersible floating tablet and preparation method therefor | |
| CN103314988A (en) | Insecticidal composition containing pyridalyl and synthetic pyrethroids | |
| CN102669149A (en) | Insect and acarid killing composition containing spinosad and bifenthrin and application of insect and acarid killing composition | |
| CN103155935B (en) | Binary pesticide composition | |
| CN101971829B (en) | Chlorantraniliprole and azadirachtin complex water dispersible granule and preparation method thereof | |
| CN105724395B (en) | A kind of binary pesticide composition and its application | |
| CN104026146B (en) | A kind of binary insecticides and purposes | |
| CN105613511A (en) | Agricultural pesticide composition and application thereof | |
| CN101961017B (en) | Flubendiamide and azadirachtin compounded water dispersible granules and preparation method thereof | |
| CN104872170B (en) | Gamma cyhalothrin emamectin-benzoate aqueous microsphere shot agent | |
| CN104522041A (en) | Flonicamid and efficient cyhalothrin containing insecticide composition | |
| CN110024792A (en) | Agricultural double-crossed Pesticidal combination and its application | |
| CN104186471A (en) | Pesticide composition containing cyhalodiamide and methoxyfenozide | |
| CN104026156B (en) | A kind of binary pesticide composition and application thereof | |
| CN102907438A (en) | Insecticidal composite containing ZJ3757 and pymetrozine | |
| CN103875699B (en) | Composition containing pyrethroid pesticide and applications thereof | |
| CN101971830A (en) | Chlorantraniliprole and rotenone complex insecticidal water dispersible granule and preparation method thereof | |
| CN105660646A (en) | Agricultural insecticide composition and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150923 |
|
| WD01 | Invention patent application deemed withdrawn after publication |