CN104919317A - 使用呼吸气体的癌症诊断方法 - Google Patents
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- CN104919317A CN104919317A CN201380068473.9A CN201380068473A CN104919317A CN 104919317 A CN104919317 A CN 104919317A CN 201380068473 A CN201380068473 A CN 201380068473A CN 104919317 A CN104919317 A CN 104919317A
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- 206010006187 Breast cancer Diseases 0.000 claims description 53
- 208000026310 Breast neoplasm Diseases 0.000 claims description 53
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 claims description 24
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 24
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 19
- 201000002510 thyroid cancer Diseases 0.000 claims description 18
- RKIMETXDACNTIE-UHFFFAOYSA-N 1,1,2,2,3,3,4,4,5,5,6,6-dodecafluorocyclohexane Chemical compound FC1(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C1(F)F RKIMETXDACNTIE-UHFFFAOYSA-N 0.000 claims description 14
- BCCOBQSFUDVTJQ-UHFFFAOYSA-N octafluorocyclobutane Chemical compound FC1(F)C(F)(F)C(F)(F)C1(F)F BCCOBQSFUDVTJQ-UHFFFAOYSA-N 0.000 claims description 14
- -1 perfluor-1-heptene Chemical compound 0.000 claims description 14
- UZUFPBIDKMEQEQ-UHFFFAOYSA-N perfluorononanoic acid Chemical compound OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F UZUFPBIDKMEQEQ-UHFFFAOYSA-N 0.000 claims description 14
- SNGREZUHAYWORS-UHFFFAOYSA-N perfluorooctanoic acid Chemical compound OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F SNGREZUHAYWORS-UHFFFAOYSA-N 0.000 claims description 14
- 238000004817 gas chromatography Methods 0.000 claims description 13
- PCIUEQPBYFRTEM-UHFFFAOYSA-M 2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-nonadecafluorodecanoate Chemical compound [O-]C(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F PCIUEQPBYFRTEM-UHFFFAOYSA-M 0.000 claims description 12
- 239000004341 Octafluorocyclobutane Substances 0.000 claims description 12
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 claims description 12
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- AEXMKKGTQYQZCS-UHFFFAOYSA-N 3,3-dimethylpentane Chemical compound CCC(C)(C)CC AEXMKKGTQYQZCS-UHFFFAOYSA-N 0.000 description 2
- 206010001233 Adenoma benign Diseases 0.000 description 2
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- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- RCOXMOQVMZTXOO-UHFFFAOYSA-N 5-(2-methylpropyl)nonane Chemical compound CCCCC(CC(C)C)CCCC RCOXMOQVMZTXOO-UHFFFAOYSA-N 0.000 description 1
- 208000000571 Fibrocystic breast disease Diseases 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 1
- 208000015634 Rectal Neoplasms Diseases 0.000 description 1
- CWHJIJJSDGEHNS-MYLFLSLOSA-N Senegenin Chemical compound C1[C@H](O)[C@H](O)[C@@](C)(C(O)=O)[C@@H]2CC[C@@]3(C)C(CC[C@]4(CCC(C[C@H]44)(C)C)C(O)=O)=C4[C@@H](CCl)C[C@@H]3[C@]21C CWHJIJJSDGEHNS-MYLFLSLOSA-N 0.000 description 1
- 208000033781 Thyroid carcinoma Diseases 0.000 description 1
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- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical compound O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
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- 229940037467 helicobacter pylori Drugs 0.000 description 1
- PQPVPZTVJLXQAS-UHFFFAOYSA-N hydroxy-methyl-phenylsilicon Chemical class C[Si](O)C1=CC=CC=C1 PQPVPZTVJLXQAS-UHFFFAOYSA-N 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
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- 210000002700 urine Anatomy 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
Classifications
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
- G01N33/4975—Physical analysis of biological material of gaseous biological material, e.g. breath other than oxygen, carbon dioxide or alcohol, e.g. organic vapours
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
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- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7206—Mass spectrometers interfaced to gas chromatograph
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/0047—Organic compounds
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Physiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
Description
试验结果 | 组织检查结果 | |
盲测1 | 乳腺癌 | FA(纤维腺瘤) |
盲测2 | 乳腺癌 | FA+肺癌 |
盲测3 | 乳腺癌 | IDC新辅助治疗乳腺癌 |
盲测4 | 乳腺癌 | FA(纤维腺瘤) |
盲测5 | 乳腺癌 | IDC乳腺癌 |
盲测6 | 健康 | 正常 |
盲测7 | 乳腺癌 | IDC乳腺癌 |
盲测8 | 乳腺癌 | FCC纤维性囊肿病 |
Claims (16)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2012-0153283 | 2012-12-26 | ||
KR20120153283 | 2012-12-26 | ||
PCT/KR2013/011848 WO2014104649A1 (ko) | 2012-12-26 | 2013-12-19 | 호흡가스를 이용한 암의 진단방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104919317A true CN104919317A (zh) | 2015-09-16 |
CN104919317B CN104919317B (zh) | 2018-01-02 |
Family
ID=51021633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380068473.9A Expired - Fee Related CN104919317B (zh) | 2012-12-26 | 2013-12-19 | 使用呼吸气体的癌症诊断方法 |
Country Status (8)
Country | Link |
---|---|
US (1) | US9955898B2 (zh) |
EP (1) | EP2940472B1 (zh) |
JP (1) | JP6159821B2 (zh) |
KR (1) | KR101467482B1 (zh) |
CN (1) | CN104919317B (zh) |
HK (1) | HK1211341A1 (zh) |
RU (1) | RU2639254C2 (zh) |
WO (1) | WO2014104649A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108700563A (zh) * | 2016-02-10 | 2018-10-23 | Mdb诊断集团有限公司 | 通过测定一种或者多种挥发性有机化合物的水平诊断癌症的方法 |
CN108709791A (zh) * | 2018-06-28 | 2018-10-26 | 江苏阳光海克医疗器械有限公司 | 呼气式癌症检测仪专用热解析机构 |
CN113167787A (zh) * | 2018-11-28 | 2021-07-23 | 新加坡国立大学 | 癌症和/或结核病的检测方法 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101948046B1 (ko) * | 2014-07-11 | 2019-02-15 | 한국생명공학연구원 | 폐암 검출용 동물 바이오센서를 이용한 냄새 변별 훈련장치 및 그 용도 |
EP3262416B1 (en) * | 2015-02-27 | 2018-12-26 | Hosmotic SRL | Method for the diagnosis of endometrial carcinoma |
KR101653502B1 (ko) | 2015-06-12 | 2016-09-09 | 한국 한의학 연구원 | 미병 분류를 보조하는 컴퓨팅 장치 및 방법 |
KR101956346B1 (ko) * | 2018-05-09 | 2019-03-08 | 서울대학교산학협력단 | 휘발성 유기화합물을 이용한 암 진단용 조성물 |
US11828210B2 (en) | 2020-08-20 | 2023-11-28 | Denso International America, Inc. | Diagnostic systems and methods of vehicles using olfaction |
US11813926B2 (en) | 2020-08-20 | 2023-11-14 | Denso International America, Inc. | Binding agent and olfaction sensor |
US11636870B2 (en) | 2020-08-20 | 2023-04-25 | Denso International America, Inc. | Smoking cessation systems and methods |
US12017506B2 (en) | 2020-08-20 | 2024-06-25 | Denso International America, Inc. | Passenger cabin air control systems and methods |
US11932080B2 (en) | 2020-08-20 | 2024-03-19 | Denso International America, Inc. | Diagnostic and recirculation control systems and methods |
US11760169B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Particulate control systems and methods for olfaction sensors |
US11881093B2 (en) | 2020-08-20 | 2024-01-23 | Denso International America, Inc. | Systems and methods for identifying smoking in vehicles |
US11760170B2 (en) | 2020-08-20 | 2023-09-19 | Denso International America, Inc. | Olfaction sensor preservation systems and methods |
KR102432200B1 (ko) | 2021-03-25 | 2022-08-12 | 재단법인 오송첨단의료산업진흥재단 | 형광정보 및 산성도 정보를 이용한 진단시스템 및 이를 이용한 진단방법 |
RU2760396C1 (ru) * | 2021-04-08 | 2021-11-24 | Общество с ограниченной ответственностью "Научно-технический центр"Реагенты Сибири" | Способ неинвазивной дифференциальной диагностики заболеваний органов дыхательной системы и устройство для его осуществления |
WO2024108132A1 (en) * | 2022-11-18 | 2024-05-23 | Diagnose Early, Inc. | Methods of breath-based pfas exposure assessment, and systems for practicing the same |
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EP2940472B1 (en) | 2018-11-07 |
JP2016504591A (ja) | 2016-02-12 |
US20150351662A1 (en) | 2015-12-10 |
RU2015130611A (ru) | 2017-01-27 |
US9955898B2 (en) | 2018-05-01 |
WO2014104649A1 (ko) | 2014-07-03 |
EP2940472A4 (en) | 2016-08-10 |
CN104919317B (zh) | 2018-01-02 |
KR20140083881A (ko) | 2014-07-04 |
HK1211341A1 (zh) | 2016-05-20 |
RU2639254C2 (ru) | 2017-12-20 |
KR101467482B1 (ko) | 2014-12-01 |
EP2940472A1 (en) | 2015-11-04 |
JP6159821B2 (ja) | 2017-07-05 |
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