CN1049146C - Compound Vernonia anthelmintica tablet for treating vitiligo - Google Patents
Compound Vernonia anthelmintica tablet for treating vitiligo Download PDFInfo
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- CN1049146C CN1049146C CN95113704A CN95113704A CN1049146C CN 1049146 C CN1049146 C CN 1049146C CN 95113704 A CN95113704 A CN 95113704A CN 95113704 A CN95113704 A CN 95113704A CN 1049146 C CN1049146 C CN 1049146C
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Abstract
The present invention relates to a compound vernonia anthelmintica tablet for treating vitiligo, which contains traditional Chinese medicine and a trace element-copper sulfate as raw material, wherein the traditional Chinese medicine comprises vernonia anthelmintica, barbary wolfberry fruit, psoralea fruit, fleeceflower root, yerbadetajo herba ecliptae, puncturevine caltrop fruit, dried rehmannia, red sage root and radix glycyrrhiza. The present invention also contains a traditional Chinese medicine tablet prepared from magnesium stearate and 10% of starch gelatine size as auxiliary material. Clinical observation and experiments of 429 patients show that a cure rate is 17.25%, a rate for taking effect is 48.25%, an effective rate is 34.03% and a total effective rate is 99.53% after the patients are treated for 3 to 5 treatment courses. With the advantages of obvious and stable curative effect, low relapse rate, short treatment course, obvious effect, etc., the present invention can be widely popularized and used in clinical application.
Description
The invention belongs to the medicinal preparation technical field of the product that contains raw material or fuzzy structure, specifically derive from plant.
Vitiligo is common a kind of dermatosis, and white macula appears in cardinal symptom skin, and white macula appears in the severe patient face, even a sheet of skin presents white macula, has a strong impact on beauty treatment.Treat leukodermic Chinese patent medicine clinically and mainly contain white erosion ball, this medication journey is very long, generally wants 3～10 courses of treatment, tens days at least, some months at most, it is very slow to increase melanin on the patient skin, after treatment after a while, pore can only occur on patient's the skin, can not be linked to be sheet, therapeutic effect is not remarkable, does not consolidate, and relapse rate is very high.Also have a kind of Chinese patent medicine vitiligo sheet, curative effect is very low, does not use clinically.
The objective of the invention is to overcome the shortcoming of said medicine, provide a kind of treatment vitiligo dermatosis evident in efficacy, consolidate, have no side effect, the tablet that adopts Chinese medicine to make.
For achieving the above object, the solution that the present invention adopts is: it comprises with the Chinese medicine Fructus Psoraleae, Radix Polygoni Multiflori, Herba Ecliptae, Fructus Tribuli, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae is extract and the medium-height grass Caulis Vernoniae andersonii that raw material is produced, medlar powder, and the Chinese medicinal tablet that is mixed and made into trace element copper sulfate, in its proportion of raw materials, each percentages of ingredients content is: Caulis Vernoniae andersonii 11～25% Fructus Lycii 1.5～10% Fructus Psoraleaes 9～24% Radix Polygoni Multiflori 9～24% Herba Ecliptaes 9～24% Fructus Tribulis 9～24% Radix Rehmanniae 4.5～15% Radix Salviae Miltiorrhizaes 2.5～10% Radix Glycyrrhizaes 1.5～10% copper sulfate 0.002～0.005%
In proportioning of the present invention, also comprising with magnesium stearate, 10% starch gelatin slurry is adjuvant, and the degree of its each adjuvant is:
Magnesium stearate 0.21～0.25%
10% starch gelatin slurry 3～5%
Caulis Vernoniae andersonii in proportioning raw materials of the present invention, Fructus Psoraleae, Radix Polygoni Multiflori, Fructus Tribuli have can swash in vivo tryrosinase, quickens melanic formation and strengthens photosensitization, and Radix Salviae Miltiorrhizae, Radix Rehmanniae have blood circulation promoting and blood stasis dispelling, the effects such as increasing melanin of dispeling the wind.
The present invention tests through clinical observation, cure rate is 17.25%, obvious effective rate is 48.25%, effective percentage is 34.03%, total effective rate is 99.53%, after 30 days course of therapy, melanin appears in most patient skin white maculas, it has short treating period, instant effect, evident in efficacy, advantage such as relapse rate is low, can extensively promote the use of clinically.
The inventor has provided used raw material, adjuvant and the proportioning of first embodiment of the invention (is example with 100000 of production products of the present invention):
Caulis Vernoniae andersonii 28kg Fructus Lycii 7kg
Fructus Psoraleae 24kg Radix Polygoni Multiflori 24kg
Herba Ecliptae 24kg Fructus Tribuli 24kg
Radix Rehmanniae 16kg Radix Salviae Miltiorrhizae 7kg
Radix Glycyrrhizae 5kg copper sulfate 0.007kg
The starch gelatin slurry 6kg of magnesium stearate 0.37kg 10%
Its preparation technology is:
1. get Fructus Psoraleae, Radix Polygoni Multiflori, Herba Ecliptae, Fructus Tribuli, Radix Rehmanniae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae and choose decontamination, weigh, clean fast, add 8 to 10 times of water gagings and decoct three times by the weight of proportioning, each 1.5 to 2 hours, filter, merge three times filtrate, be evaporated to into syrupy shape, dust, standby.Take by weighing the adjuvant magnesium stearate by proportioning, make 10% starch gelatin slurry.
2. get Caulis Vernoniae andersonii, Fructus Lycii, choose decontamination, cleaning, drying are fast weighed by proportioning, and pulverize separately becomes fine powder, mix, and granulate with 10% starch gelatin slurry, and 100 mesh sieves were pulverized in cold drying, and were standby.
3. get above two kinds of medicated powder, mix homogeneously is granulated with moistening 14 mesh sieves that pass through of 55% ethanol, and cold drying after 12 mesh sieve granulate, adds the magnesium stearate lubricant, tabletting.
4. packing by quality standard of the present invention after the assay was approved.
The inventor has provided used raw material, adjuvant and the proportioning thereof of second embodiment of the invention (is example with 100000 of production products of the present invention):
Caulis Vernoniae andersonii 36kg Fructus Lycii 8kg
Fructus Psoraleae 36kg Radix Polygoni Multiflori 36kg
Herba Ecliptae 36kg Fructus Tribuli 36kg
Radix Rehmanniae 20kg Radix Salviae Miltiorrhizae 8kg
Radix Glycyrrhizae 5kg sulphuric acid steel 0.011kg
The starch gelatin slurry 7kg of magnesium stearate 0.5kg 10%
Its preparation technology and first embodiment are identical.
The inventor adopts the leukodermic compound Vernonia anthelmintica tablet of treatment of first embodiment of the invention preparation to carry out the clinical observation test, treatment patients with vitiligo 429 examples, wherein male 244 examples, woman's 185 examples, the oldest 68 years old, minimum 4 years old, 20～40 years old patient's 276 examples, patient's 54 examples more than 40 years old.In patients with vitiligo 429 examples, the course of disease had 54 examples, the patient of the course of disease in 1～5 year that 126 examples are arranged in 1 year with interior patient, and the course of disease has 150 examples the patient more than 6～10 years, and the course of disease has 99 examples the patient more than 10 years, and test situation is as follows:
1. case is selected
(1) local single-shot type vitiligo: case 110 examples.Cardinal symptom be the skin lesion single-shot in any position of human body, white macula appears at any position of human body skin isolatedly.
(2) women's head-ornaments multiple types vitiligo: case 39 examples.Cardinal symptom be skin lesion in the women's head-ornaments different parts, white macula appears on people's the head-face skin symmetrically.
(3) whole body multiple types vitiligo: case 280 examples.Cardinal symptom be the skin lesion area more than 2%, majority is diffusion profile in the form of sheets, or is drop shape dense distribution, white macula appears at each position of human body whole body.
2. Therapeutic Method
The oral the present invention of 429 routine patients, each 5 of adult's consumption, three times on the one, 30 days is a course of treatment, drug withdrawal is 4 days between the course of treatment.The course of disease was taken medicine 3～5 courses of treatment with interior patient in 1 year, and the patient in 1～5 year takes medicine 5～10 courses of treatment, and the patient in 6～8 years takes medicine 10～15 courses of treatment, and the patient takes medicine 15～20 courses of treatment more than 10 years.
3. criterion of therapeutical effect
Recovery from illness: the pigment on the leukoderma recovers normal.
Produce effects: the rehabilitation area reaches more than 60% of white macula area on the leukoderma.
Effectively: the white macula area dwindles on the skin, occurs melanin granule in the white macula.
Invalid: white macula no change before and after treatment on the skin.
4. clinical observation test and result of the test
After patients with vitiligo was taken the present invention, the rehabilitation of skin surface melanin was divided into for three phases:
The melanin apparition: after patients with vitiligo was taken the present invention course of treatment, pigment was deepened around the white macula, or occurs the big melanin point of needle point in the white macula.
The melanin rise period: after patients with vitiligo was taken the present invention 2～3 courses of treatment, melanin was deepened around the white macula, and white macula contracts in gradually, and the melanin point in the white macula increases, and increases.
The melanin incorporating period: after patients with vitiligo was taken the present invention 3～5 courses of treatment, the melanin point in the white macula enlarged gradually, is fused into lamellar mutually, and lamellar is converged, and white macula disappears and rehabilitation.
Result of the test: 429 routine patients with vitiligo, take the present invention 3～5 courses of treatment after, 74 examples of fully recovering account for 17.25%; Produce effects 207 examples account for 48.25%; Effective 146 examples account for 34.03%; Invalid 2 examples account for 0.47%; Total effective rate is 99.53%.
Function of the present invention and purposes: the present invention has liver-kidney tonifying, expelling wind and activating blood flow stagnation resolvation, increases Strong human body immunity and promotion melanin pigmentation function are used for the treatment of leucoderma disease.
Usage of the present invention and consumption: be grown up took three times on the 1st, and each 5, children reduce by half, One month is a course for the treatment of, and the course for the treatment of, the interval was 4 days, generally took 3～5 courses for the treatment of, to the course of disease Long patient, but the course for the treatment of proper extension.
Taboo of the present invention: diet acid in the treatment phase, peppery irritable food.
Storage of the present invention: sealing, shady and cool dry place storage.
The term of validity of the present invention: 2 years.
Claims (1)
1, the leukodermic compound Vernonia anthelmintica tablet of a kind of treatment is characterized in that it comprises with Chinese medicine Fructus Psoraleae, Radix Polygoni Multiflori, Herba Ecliptae, Fructus Tribuli, Radix Rehmanniae.Radix Salviae Miltiorrhizae, Radix Glycyrrhizae is extract and the Chinese medicine Caulis Vernoniae andersonii that raw material is produced, medlar powder, and the Chinese medicinal tablet that is mixed and made into trace element copper sulfate, in its proportion of raw materials, each percentages of ingredients content is: Caulis Vernoniae andersonii 11～25% Fructus Lycii 1.5～10% Fructus Psoraleaes 9～24% Radix Polygoni Multiflori 9～24% Herba Ecliptaes 9～24% Fructus Tribulis 9～24% Radix Rehmanniae 4.5～15% Radix Salviae Miltiorrhizaes 2.5～10% Radix Glycyrrhizaes 1.5～10% are dredged sour copper 0.002～0.005%
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95113704A CN1049146C (en) | 1995-07-21 | 1995-07-21 | Compound Vernonia anthelmintica tablet for treating vitiligo |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95113704A CN1049146C (en) | 1995-07-21 | 1995-07-21 | Compound Vernonia anthelmintica tablet for treating vitiligo |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1141183A CN1141183A (en) | 1997-01-29 |
| CN1049146C true CN1049146C (en) | 2000-02-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95113704A Expired - Fee Related CN1049146C (en) | 1995-07-21 | 1995-07-21 | Compound Vernonia anthelmintica tablet for treating vitiligo |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1049146C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325068C (en) * | 2004-12-17 | 2007-07-11 | 斯拉甫·艾白 | Use of insect-expelling saligna injection liquid for cough and gasp catabasis drug |
| EP2150262B1 (en) | 2007-04-17 | 2016-08-31 | Bayer Consumer Care AG | Use of vernonia appendiculata extract for improving the skin status |
| CN114796311A (en) * | 2021-01-27 | 2022-07-29 | 保定华仁白癜风医院 | Pill of vernonia amygdalina for eliminating leukosis |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089861A (en) * | 1992-12-12 | 1994-07-27 | 杜文超 | A kind of treatment vitiligo medicine and compound method thereof |
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1995
- 1995-07-21 CN CN95113704A patent/CN1049146C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089861A (en) * | 1992-12-12 | 1994-07-27 | 杜文超 | A kind of treatment vitiligo medicine and compound method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 中西医结合杂志1987,7(6) 1987.1.1 程运乾 * |
| 河南中医1985 1985.1.1 符文缯等 * |
| 河南中医1985 1985.1.1 符文缯等;中西医结合杂志1987,7(6) 1987.1.1 程运乾 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1141183A (en) | 1997-01-29 |
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