CN104909987A - Method for extracting mannitol in kelp - Google Patents
Method for extracting mannitol in kelp Download PDFInfo
- Publication number
- CN104909987A CN104909987A CN201510327752.3A CN201510327752A CN104909987A CN 104909987 A CN104909987 A CN 104909987A CN 201510327752 A CN201510327752 A CN 201510327752A CN 104909987 A CN104909987 A CN 104909987A
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- China
- Prior art keywords
- sea
- tangle
- usp mannitol
- solution
- shearing
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a method for extracting mannitol in kelp. The method comprises the following steps: selecting raw materials, soaking, shearing, crushing, performing nanometer milling, regulating the pH value, filtering, neutralizing, concentrating, performing ethanol precipitation, and drying, thereby obtaining the finished product. The method disclosed by the invention has the beneficial effects that the design is reasonable, the process period is effectively shortened, and the dissolution rate of the unit product is greatly improved by virtue of a nanometer wall-breaking technology. Meanwhile, the yield is improved, the energy consumption is reduced, the operating safety is guaranteed, and the method is an ideal selection of industrial production.
Description
Technical field
The present invention relates to technical field of marine animal extraction, be specifically related to a kind of method extracting N.F,USP MANNITOL in sea-tangle.
Background technology
N.F,USP MANNITOL is the isomers of Sorbitol Powder, and it can as good diuretic(s) at field of medicaments, reduces the medicine of intracranial pressure, intraocular pressure and treatment kidney, also can be used as the thinner of the vehicle of tablet and solid, liquid.The one of to take N.F,USP MANNITOL as the formula mannitol injection liquid of main component be clinical rescue brain disorder is commonly used height and is oozed depressor.At field of food, N.F,USP MANNITOL due to the water-absorbent in sugar and sugar alcohol minimum, and there is sweet taste, can be used as the sweeting agent of the anti-stick powder of cake and food with low sugar content.At field of industrial production, be that poly-N.F,USP MANNITOL-propylene oxide ether that initiator is made is widely used in plastic industry with N.F,USP MANNITOL.Apply so widely based on N.F,USP MANNITOL, how to extract high-quality N.F,USP MANNITOL fast and efficiently, thus meet the heavy demand of industrial application, be the research emphasis of person skilled always.Industrial production N.F,USP MANNITOL mainly contains two kinds of techniques in the world, and one take sea-tangle as raw material, and one is for raw material with sucrose and glucose, and the existing method extracting N.F,USP MANNITOL from sea-tangle mostly to there is process cycle long, output is lower, and energy consumption is high, and operational safety can not get the shortcomings such as powerful guarantee.
Therefore, need badly and design and develop a kind of method extracting N.F,USP MANNITOL from sea-tangle newly, to solve prior art above shortcomings.
Summary of the invention
The object of this invention is to provide a kind of method extracting N.F,USP MANNITOL in sea-tangle, to overcome currently available technology above shortcomings.
The object of the invention is to be achieved through the following technical solutions:
Extract a method for N.F,USP MANNITOL in sea-tangle, comprise the following steps:
First, choose raw material, described raw material comprises sea-tangle, sulfuric acid, calcium hydroxide and ethanol;
Secondly, pulverized by sea-tangle, be soaked in water, the quality of described water is 10 times of sea-tangle quality, soaks, in the stirred pot with shearing function, carries out shearing-crushing to sea-tangle;
Again, the solution of nanometer sand mill to shearing-crushing is used to mill, until cytoclasis;
Again, utilize sulphuric acid soln that solution ph is adjusted to 2;
From secondary, filter the gluey macromolecular substance of remove portion;
Then, add aqua calcis and neutralize, cross and filter insoluble substance;
Finally, adopt mechanical steam recompression technology to be concentrated into 1/4 of original volume to solution, then the volume fraction adding concentrated rear solution 2 times amount is the ethanol of 95%, stir, collected by centrifugation canescence bulk precipitate thing, dries it, obtains finished product N.F,USP MANNITOL.
Further, described soak time is 2 hours.
Further, the volume fraction of described sulfuric acid is 10%.
Further, the add-on of described aqua calcis is 1.0 mg/ml.
Beneficial effect of the present invention is: reasonable in design, effectively shortens process cycle, and nanometer wall breaking technology greatly improves the solubility rate of unit product, improves output simultaneously, reduces energy consumption, has ensured processing safety, is the ideal chose of suitability for industrialized production.
Embodiment
The embodiment be clearly and completely described the technical scheme in the embodiment of the present invention is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, the every other embodiment that those of ordinary skill in the art obtain, all belongs to the scope of protection of the invention.
Embodiment 1:
According to embodiments of the invention, provide a kind of method extracting N.F,USP MANNITOL in sea-tangle, specifically comprise the following steps:
First, choose raw material, described raw material comprises sea-tangle, sulfuric acid, calcium hydroxide and ethanol;
Secondly, pulverized by sea-tangle, be soaked in water, the quality of described water is 10 times of sea-tangle quality, soaks 2 hours, in the stirred pot with shearing function, carries out shearing-crushing to sea-tangle;
Again, the solution of nanometer sand mill to shearing-crushing is used to mill, until cytoclasis;
Again, utilize 2% sulphuric acid soln that solution ph is adjusted to 2;
From secondary, filter the gluey macromolecular substance of remove portion;
Then, the aqua calcis adding 1.0 mg/ml neutralizes, and crosses and filters insoluble substance;
Finally, adopt mechanical steam recompression technology to be concentrated into 1/4 of original volume to solution, then the volume fraction adding concentrated rear solution 2 times amount is the ethanol of 95%, stir, collected by centrifugation canescence bulk precipitate thing, dries it, obtains finished product N.F,USP MANNITOL.
The present invention is not limited to above-mentioned preferred forms; anyone can draw other various forms of products under enlightenment of the present invention; no matter but any change is done in its shape or structure; every have identical with the application or akin technical scheme, all drops within protection scope of the present invention.
Claims (4)
1. extract a method for N.F,USP MANNITOL in sea-tangle, it is characterized in that, comprise the following steps:
First, choose raw material, described raw material comprises sea-tangle, sulfuric acid, calcium hydroxide and ethanol;
Secondly, pulverized by sea-tangle, be soaked in water, the quality of described water is 10 times of sea-tangle quality, soaks, in the stirred pot with shearing function, carries out shearing-crushing to sea-tangle;
Again, the solution of nanometer sand mill to shearing-crushing is used to mill fragmentation;
Again, utilize sulphuric acid soln that solution ph is adjusted to 2;
From secondary, filter the gluey macromolecular substance of remove portion;
Then, add aqua calcis and neutralize, cross and filter insoluble substance;
Finally, adopt mechanical steam recompression technology to be concentrated into 1/4 of original volume to solution, then the volume fraction adding concentrated rear solution 2 times amount is the ethanol of 95%, stir, collected by centrifugation canescence bulk precipitate thing, dries it, obtains finished product N.F,USP MANNITOL.
2. the method extracting N.F,USP MANNITOL in sea-tangle according to claim 1, it is characterized in that, described soak time is 2 hours.
3. the method extracting N.F,USP MANNITOL in sea-tangle according to claim 2, it is characterized in that, the volume fraction of described sulfuric acid is 10%.
4. the method extracting N.F,USP MANNITOL in sea-tangle according to claim 3, it is characterized in that, the add-on of described aqua calcis is 1.0 mg/ml.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510327752.3A CN104909987A (en) | 2015-06-15 | 2015-06-15 | Method for extracting mannitol in kelp |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510327752.3A CN104909987A (en) | 2015-06-15 | 2015-06-15 | Method for extracting mannitol in kelp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104909987A true CN104909987A (en) | 2015-09-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510327752.3A Pending CN104909987A (en) | 2015-06-15 | 2015-06-15 | Method for extracting mannitol in kelp |
Country Status (1)
| Country | Link |
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| CN (1) | CN104909987A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105294398A (en) * | 2015-09-29 | 2016-02-03 | 上海市农业科学院 | Method for preparing high-purity mannitol |
| CN107641071A (en) * | 2017-11-19 | 2018-01-30 | 荣成海锐芯生物科技有限公司 | A kind of method that mannitol is extracted from sea-tangle |
| CN110776401A (en) * | 2019-11-26 | 2020-02-11 | 金玖洲新能源有限公司 | Biological alcohol extraction method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840518A (en) * | 2005-08-18 | 2006-10-04 | 山东寻山水产集团有限公司 | Process for extracting mannitol from kelp |
| CN104387232A (en) * | 2014-11-11 | 2015-03-04 | 常州大学 | Method for extracting mannose from sea vegetable |
| CN104557462A (en) * | 2014-12-17 | 2015-04-29 | 方萌 | Method for extracting mannitol |
| CN104628523A (en) * | 2013-11-15 | 2015-05-20 | 史燕青 | Method for extracting mannitol by one-step method |
-
2015
- 2015-06-15 CN CN201510327752.3A patent/CN104909987A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840518A (en) * | 2005-08-18 | 2006-10-04 | 山东寻山水产集团有限公司 | Process for extracting mannitol from kelp |
| CN104628523A (en) * | 2013-11-15 | 2015-05-20 | 史燕青 | Method for extracting mannitol by one-step method |
| CN104387232A (en) * | 2014-11-11 | 2015-03-04 | 常州大学 | Method for extracting mannose from sea vegetable |
| CN104557462A (en) * | 2014-12-17 | 2015-04-29 | 方萌 | Method for extracting mannitol |
Non-Patent Citations (1)
| Title |
|---|
| 曾凡梅: "海带甘露醇提取工艺的研究", 《农产品加工·学刊》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105294398A (en) * | 2015-09-29 | 2016-02-03 | 上海市农业科学院 | Method for preparing high-purity mannitol |
| CN105294398B (en) * | 2015-09-29 | 2017-01-25 | 上海市农业科学院 | Method for preparing high-purity mannitol |
| CN107641071A (en) * | 2017-11-19 | 2018-01-30 | 荣成海锐芯生物科技有限公司 | A kind of method that mannitol is extracted from sea-tangle |
| CN110776401A (en) * | 2019-11-26 | 2020-02-11 | 金玖洲新能源有限公司 | Biological alcohol extraction method |
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20150916 |
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| RJ01 | Rejection of invention patent application after publication |