CN104908187A - Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper - Google Patents
Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper Download PDFInfo
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- CN104908187A CN104908187A CN201510370474.XA CN201510370474A CN104908187A CN 104908187 A CN104908187 A CN 104908187A CN 201510370474 A CN201510370474 A CN 201510370474A CN 104908187 A CN104908187 A CN 104908187A
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- plug
- bottle stopper
- pressing plate
- neck
- stopper
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Abstract
The invention discloses a novel pharmaceutical bottle stopper of a composite structure. The novel pharmaceutical bottle stopper comprises a stopper crown and a stopper neck which are formed by compounding two kinds of rubber materials with different performances once. The production method of the novel pharmaceutical bottle stopper comprises the following steps: firstly, opening an upper mold plate of a vulcanizing mold, and putting mixing rubber sheets for the stopper neck onto the lower mold plate; secondly, putting a pressing plate onto the mixing runner sheets for the stopper neck; thirdly, closing the upper mold plate of the vulcanizing mold, pressurizing, and pressing the mixing rubber sheets for the stopper neck into a mold cavity of the stopper neck of the lower mold plate via the pressing plate; fourthly, opening the upper mold plate of the vulcanizing mold, taking down the pressing plate, and putting into the formula of rubber for the stopper crown; fifthly, closing the mold plate, pressurizing, vulcanizing into a rubber stopper semi-finished product according to a technology; and sixthly, taking out the vulcanized rubber stopper semi-finished product, and punching annularly at the punching point so as to obtain the novel pharmaceutical bottle stopper of the composite structure. The novel pharmaceutical bottle stopper of the composite structure is reasonable in structure design; the production method of the novel pharmaceutical bottle stopper of the composite structure has the advantages of simple and stable technology, energy conservation, consumption reduction, tiny environment pollution, low production cost, and capability of improving the finished product rate effectively.
Description
Technical field
The present invention relates to pharmaceutical field of packaging material, particularly relate to a kind of compound structure for new residence medicinal bottle stopper and manufacture method thereof.
Background technology
As everyone knows, medicinal bottle stopper is the elastomer packaging material directly contacted with medicine, has an effect, cause the bad stability of medicine between meeting and medicine.The consistency problem of bottle stopper and medicine has a strong impact on the quality of medicine, brings drug safety hidden danger to patient.In order to solve the consistency problem of bottle stopper and medicine, one of technology of current employing is exactly design high-purity rubber compounding, reduces the content of the transportable material of plug as far as possible, but thing followed problem to be plug very soft, easily be adhered, drugs packaging line is walked machine difficulty; Cost also increases greatly simultaneously.Two of technology is exactly that our company devises a kind of composite construction plug and sees Fig. 1, it comprises plug hat, plug neck, described plug neck outer wall is the face of cylinder, spigot surface is arranged at bottom, inwall is taper cylinder, label centre of surface at described plug and be provided with acupuncture ring, be preced with between circumferential edges at acupuncture ring circumferential edges and plug and be provided with antiseized projection; The high-purity rubber size using drug compatibility good with the plug neck position of medicament contact; The sizing compound formula that plug hat uses high rigidity smooth, avoids being adhered, is convenient to machine.But produce this composite construction plug usually to need to adopt two-step method moulding process: the first step, neck of leaving the boundary is produced in first sulfuration, is die-cut into single bottle stopper plug neck; Second step, puts into mould by plug neck and carries out the shaping formation of post-cure and fill in the connection be preced with.There is following shortcoming in this technique: 1, need to carry out secondary forming process, complex process, production efficiency is low; 2, due to the first vulcanization forming of plug neck, during post-cure and bizet sizing material bond loosely, easily come off, cause hidden danger of quality, security reliability is affected.
Summary of the invention
The object of the invention is to overcome the deficiency in existing medicinal bottle stopper manufacturing process technology, a kind of compound structure for new residence medicinal bottle stopper and manufacture method thereof are provided.This bottle plug structure is reasonable in design, and its manufacture method has technique simple and stable, the advantage that energy-saving and cost-reducing, environmental pollution is little, production cost is low.A kind of can effectively enhancing productivity and the compound structure for new residence medicinal bottle stopper manufacture method of finished product rate.Produce medicinal bottle stopper and there is more excellent compatible pharmaceutical performance compared with existing bottle stopper, the compound structure for new residence medicinal bottle stopper of be not adhered, be easy to away machine, be a kind of good seal performance, guarantee packaging stability of drug products and security reliability.
To achieve these goals, the present invention is achieved through the following technical solutions: a kind of compound structure for new residence medicinal bottle stopper, include plug hat, plug neck, described plug neck outer wall is the face of cylinder, spigot surface is arranged at bottom, inwall is taper cylinder, described plug is labeled centre of surface and is provided with acupuncture ring, be preced with between circumferential edges at acupuncture ring circumferential edges and plug and be provided with antiseized projection, it is characterized in that: described plug hat, to be that elastomeric material that two kinds of performances are different is disposable be composited plug neck, its material used of described bottle stopper is polyisoprene rubber, butyl rubber, two kinds in halogenated butyl rubber and TPO.
Described plug neck uses the good high-purity rubber size of drug compatibility, plug hat uses that the smooth sizing material of high rigidity is disposable to be composited.
A manufacture method for compound structure for new residence medicinal bottle stopper, it comprises the following steps:
Step one, opens sulfurizing mould cope match-plate pattern, and lower bolster is put into plug neck mixed sheet;
Step 2, plug neck mixed sheet puts pressing plate;
Step 3, the sulfurizing mould cope match-plate pattern that closes pressurizes, and will fill in neck mixed sheet press-in lower bolster plug neck die cavity by pressing plate;
Step 4, opens sulfurizing mould cope match-plate pattern, takes off pressing plate, puts into plug hat formulated rubber material;
Step 5, template of closing is pressurizeed, and is sulfided into plug semi-finished product by technique;
Step 6, takes out the plug semi-finished product vulcanizated, and makes annular die-cut, obtain compound structure for new residence medicinal bottle stopper finished product at die-cut some place.
The smooth surface that described pressing plate contacts with sizing material or have adhesive at the surface application contacted with sizing material, prevents and sizing material adhesion.
Described pressing plate is metal or plastic material.
When described pressing plate is for being plastic material, the minimum heatproof of this material is more than 130 DEG C.
In described step 2, between film and pressing plate, place spacer; In described step 3, the sulfurizing mould cope match-plate pattern that closes pressurizes, and by pressing plate and spacer, mixed sheet is pressed into lower bolster plug neck die cavity; In described step 4, open sulfurizing mould cope match-plate pattern, take off pressing plate and spacer, put into plug hat formulated rubber material.
Described spacer 11 is for there being the one in flexible sheet metal, plastic sheet and fiber cloth.
Described pressing plate is metal or plastic material; When described pressing plate is for being plastic material, the minimum heatproof of this material is more than 130 DEG C.
Described pressing plate is metal or plastic material; When described pressing plate is for being plastic material, the minimum heatproof of this material is more than 130 DEG C.
In the present invention, the high-purity rubber size using drug compatibility good with the plug neck of medicament contact, decreases the content of the transportable material of plug; The plug do not come in contact with medicine is preced with and is used the smooth sizing material of high rigidity to avoid being adhered, and is convenient to machine; Plug hat and plug neck are composited by disposable, and technique is simple, production efficiency is high, plug neck bonds firmly with plug bizet, and difficult drop-off, security reliability is high.
Further, between film and pressing plate, place spacer, play the effect of isolation bed die sizing material.
Compared with prior art, tool has the following advantages for a kind of compound structure for new residence medicinal bottle stopper of the present invention and manufacture method thereof:
1, this compound structure for new residence medicinal bottle stopper reasonable in design, its manufacture method has technique simple and stable, energy-saving and cost-reducing, environmental pollution is little, production cost is low, the advantage of effective raising finished product rate; Its medicinal bottle stopper produced has more excellent compatible pharmaceutical performance, better sealing property, guarantees packaging stability of drug products and security reliability compared with existing bottle stopper.
2, because product adopts one-shot forming technique, its production efficiency can be enhanced about more than once, and product is qualified reaches 99%, energy-saving and cost-reducing, obviously reduces production cost.
Accompanying drawing explanation
Fig. 1 is medicinal bottle stopper sectional structure schematic diagram in prior art;
Fig. 2 is the process chart of the embodiment of the present invention 1;
Fig. 3 is the process chart of the embodiment of the present invention 2.
In figure, sequence number is: 1, plug hat; 2, neck is filled in; 3, lower bolster; 4, neck mixed sheet is filled in; 5, pressing plate; 6, cope match-plate pattern; 7, lower bolster plug neck die cavity; 8, hat sizing material is filled in; 9, plug semi-finished product; 10, die-cut point; 11, spacer; 12, adhesive.
Detailed description of the invention
By reference to the accompanying drawings the specific embodiment of the present invention is further described below, understands the present invention.
Embodiment one, see accompanying drawing 2, a kind of compound structure for new residence medicinal bottle stopper, include plug hat 1, plug neck 2, described plug neck 1 outer wall is the face of cylinder, and spigot surface is arranged at bottom, inwall is taper cylinder, described plug is preced with 2 upper surface centers and is provided with acupuncture ring, be preced with between circumferential edges be provided with antiseized projection at acupuncture ring circumferential edges and plug, and described plug hat 1, to fill in neck 2 be that elastomeric material that two kinds of performances are different is disposable is composited; The sizing material that the high-purity rubber size that described plug neck 2 uses drug compatibility good, plug hat 1 use high rigidity smooth is disposable to be composited; Its manufacture method, comprises the following steps: step one, opens sulfurizing mould cope match-plate pattern 6, and lower bolster 3 is put into plug neck mixed sheet 4; Step 2, plug neck mixed sheet 4 puts pressing plate 5; Step 3, the sulfurizing mould cope match-plate pattern 6 that closes pressurizes, and by pressing plate 5, plug neck mixed sheet 4 is pressed into lower bolster plug neck die cavity 7; Step 4, opens sulfurizing mould cope match-plate pattern 6, takes off pressing plate 5, puts into plug hat 1 formulated rubber material 8; Step 5, template of closing pressurization 6, is sulfided into plug semi-finished product 9 by technique; Step 6, takes out the plug semi-finished product 9 vulcanizated, and makes annular die-cut, obtain compound structure for new residence medicinal bottle stopper finished product of the present invention at die-cut point 10 place; The smooth surface that described pressing plate contacts with sizing material or have adhesive 12 at the surface application contacted with sizing material, prevents and sizing material adhesion; Described pressing plate 5 is metal or plastic material; Described pressing plate be 5 for plastic material time, the minimum heatproof of this material is more than 130 DEG C.
Embodiment two, see accompanying drawing 3, a kind of compound structure for new residence medicinal bottle stopper, include plug hat 1, plug neck 2, described plug neck 1 outer wall is the face of cylinder, and spigot surface is arranged at bottom, inwall is taper cylinder, described plug is preced with 2 upper surface centers and is provided with acupuncture ring, be preced with between circumferential edges be provided with antiseized projection at acupuncture ring circumferential edges and plug, and described plug hat 1, to fill in neck 2 be that elastomeric material that two kinds of performances are different is disposable is composited; The sizing material that the high-purity rubber size that described plug neck 2 uses drug compatibility good, plug hat 1 use high rigidity smooth is disposable to be composited; Its manufacture method, comprises the following steps: step one, opens sulfurizing mould cope match-plate pattern 6, and lower bolster 3 is put into plug neck mixed sheet 4; Step 2, plug neck mixed sheet 4 puts pressing plate 5, places spacer 11 between film 4 and pressing plate 5; Step 3, the sulfurizing mould cope match-plate pattern 6 that closes pressurizes, and by pressing plate 5 and spacer 11, plug neck mixed sheet 4 is pressed into lower bolster plug neck die cavity 7; Step 4, opens sulfurizing mould cope match-plate pattern 6, takes off pressing plate 5 and spacer 11, puts into plug hat 1 formulated rubber material 8; Step 5, template of closing pressurization 6, is sulfided into plug semi-finished product 9 by technique; Step 6, takes out the plug semi-finished product 9 vulcanizated, and makes annular die-cut, obtain compound structure for new residence medicinal bottle stopper finished product of the present invention at die-cut point 10 place; Described spacer 11 is for there being the one in flexible sheet metal, plastic sheet and fiber cloth; Described pressing plate 5 is metal or plastic material; Described pressing plate be 5 for plastic material time, the minimum heatproof of this material is more than 130 DEG C.
Embodiment is just for the ease of understanding technical scheme of the present invention; do not form limiting the scope of the invention; every do not depart from technical solution of the present invention interior perhaps above scheme is done according to technical spirit of the present invention any simple modification, equivalent variations and modification, all still belong within scope.
Claims (10)
1. a compound structure for new residence medicinal bottle stopper, include plug to be preced with (1), to fill in neck (2), described plug neck (1) outer wall is the face of cylinder, spigot surface is arranged at bottom, inwall is taper cylinder, described plug is preced with (2) upper surface center and is provided with acupuncture ring, be preced with between circumferential edges and is provided with antiseized projection, it is characterized in that at acupuncture ring circumferential edges and plug: described plug hat (1), (2) fill in neck be that elastomeric material that two kinds of performances are different is disposable is composited.
2. a kind of compound structure for new residence medicinal bottle stopper according to claim 1, is characterized in that: the high-purity rubber size that (2) described plug neck uses drug compatibility good, the plug hat sizing material that (1) use high rigidity is smooth is disposable to be composited.
3. a manufacture method for compound structure for new residence medicinal bottle stopper as claimed in claim 1 or 2, it comprises the following steps:
(6) step one, open sulfurizing mould cope match-plate pattern, lower bolster (3) on put into plug neck mixed sheet (4);
Step 2, plug neck mixed sheet (4) on put pressing plate (5);
Step 3, (6) the sulfurizing mould cope match-plate pattern that closes pressurizes, and (5) (7) (4) plug neck mixed sheet is pressed into lower bolster plug neck die cavity by pressing plate;
(6) step 4, open sulfurizing mould cope match-plate pattern, takes off pressing plate (5), put into plug hat (1) with formulated rubber material (8);
Step 5, (9) (6) template of closing pressurization, be sulfided into plug semi-finished product by technique;
Step 6, (9) the plug semi-finished product that taking-up vulcanizates, are (10) located to make annular at die-cut point die-cut, are obtained compound structure for new residence medicinal bottle stopper finished product.
4. the manufacture method of a kind of compound structure for new residence medicinal bottle stopper according to claim 3, is characterized in that: the smooth surface that described pressing plate contacts with sizing material or have adhesive (12) at the surface application contacted with sizing material, prevents and sizing material adhesion.
5. the manufacture method of a kind of compound structure for new residence medicinal bottle stopper according to claim 4, is characterized in that: (5) described pressing plate is metal or plastic material.
6. the manufacture method of a kind of compound structure for new residence medicinal bottle stopper according to claim 5, is characterized in that: when (5) described pressing plate for being plastic material, the minimum heatproof of this material is more than 130 DEG C.
7. the manufacture method of a kind of compound structure for new residence medicinal bottle stopper according to claim 3, is characterized in that: in described step 2, film (4) and pressing plate (5) between place spacer (11); In described step 3, (6) the sulfurizing mould cope match-plate pattern that closes pressurizes, and (5) (11) (4) mixed sheet is pressed into lower bolster plug neck die cavity (7) with spacer by pressing plate; In described step 4, open sulfurizing mould cope match-plate pattern (6), take off pressing plate (5) with spacer (11), put into plug hat (1) with formulated rubber material (8).
8. the manufacture method of a kind of compound structure for new residence medicinal bottle stopper according to claim 7, is characterized in that: described spacer is (11) for there being the one in flexible sheet metal, plastic sheet and fiber cloth.
9. the manufacture method of a kind of compound structure for new residence medicinal bottle stopper according to claim 7, is characterized in that: (5) described pressing plate is metal or plastic material; When described pressing plate is (5) for plastic material, the minimum heatproof of this material is more than 130 DEG C.
10. the manufacture method of a kind of compound structure for new residence medicinal bottle stopper according to claim 8, is characterized in that: (5) described pressing plate is metal or plastic material; When described pressing plate is (5) for plastic material, the minimum heatproof of this material is more than 130 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510370474.XA CN104908187A (en) | 2015-06-30 | 2015-06-30 | Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510370474.XA CN104908187A (en) | 2015-06-30 | 2015-06-30 | Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper |
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| CN104908187A true CN104908187A (en) | 2015-09-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510370474.XA Pending CN104908187A (en) | 2015-06-30 | 2015-06-30 | Novel pharmaceutical bottle stopper of composite structure and production method of novel pharmaceutical bottle stopper |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464326A (en) * | 1982-02-15 | 1984-08-07 | Fuji Rubber Co. Ltd. | Method of manufacturing contact rubber structure |
| US4915243A (en) * | 1985-05-28 | 1990-04-10 | Daikyo Gomu Seiko, Ltd. | Resin-laminated rubber closure for a medical vial |
| CN101579906A (en) * | 2008-05-15 | 2009-11-18 | 宜昌市华强塑业有限责任公司 | Method for producing medical rubber bottle cork made of dual composite material |
| CN102038606A (en) * | 2010-11-17 | 2011-05-04 | 安徽华峰医药橡胶有限公司 | Manufacturing method of coating rubber stopper for lyophilized powder |
| CN102743287A (en) * | 2011-04-20 | 2012-10-24 | 江苏博生医用新材料股份有限公司 | New type coated drug bottle plug and manufacturing method thereof |
-
2015
- 2015-06-30 CN CN201510370474.XA patent/CN104908187A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4464326A (en) * | 1982-02-15 | 1984-08-07 | Fuji Rubber Co. Ltd. | Method of manufacturing contact rubber structure |
| US4915243A (en) * | 1985-05-28 | 1990-04-10 | Daikyo Gomu Seiko, Ltd. | Resin-laminated rubber closure for a medical vial |
| CN101579906A (en) * | 2008-05-15 | 2009-11-18 | 宜昌市华强塑业有限责任公司 | Method for producing medical rubber bottle cork made of dual composite material |
| CN102038606A (en) * | 2010-11-17 | 2011-05-04 | 安徽华峰医药橡胶有限公司 | Manufacturing method of coating rubber stopper for lyophilized powder |
| CN102743287A (en) * | 2011-04-20 | 2012-10-24 | 江苏博生医用新材料股份有限公司 | New type coated drug bottle plug and manufacturing method thereof |
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Application publication date: 20150916 |
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