CN104906521A - Traditional Chinese medicine preparation for treating tetanus - Google Patents
Traditional Chinese medicine preparation for treating tetanus Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating tetanus. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 11-16 parts of boenninghausenia albiflora, 9-13 parts of bamboo juice, 10-15 parts of drumfish bladder, 7-10 parts of periostracum cicada, 9-12 parts of rhizoma arisaematis, 10-15 parts of typhonium giganteum, 3-6 parts of gecko, 12-16 parts of radix curcumae, 10-17 parts of common calanthe herb, 8-11 parts of rhizoma typhonii, 9-14 parts of wadalee-gum-tree, 6-14 parts of ginseng fruits, 13-20 parts of radix pseudostellariae, 11-15 parts of centella and 9-16 parts of basella alba. The traditional Chinese medicine preparation has the efficacies of dispelling wind heat, relieving spasm, tranquilizing mind and allaying excitement, is capable of effectively preventing and treating tetanus, and has an obvious inhibiting effect on clostridium tetani; the traditional Chinese medicine preparation disclosed by the invention is low in loss of effective components, high in curative effect, free of side effects and low in price; and the burden of a patient can be relieved.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat tetanic Chinese medicine preparation.
Background technology
Tetanus has another name called tatanic, is commonly called as lock-jaw, and be a kind of acute toxic zoonosis caused through wound infection by clostridium tetani, main clinic symptoms is gnathospasma, and local or whole-body muscle are paroxysmal or tetanic spasm.Tetanus bacillus infection invades human body via skin or mucosa wound, growth and breeding under anaerobic environment, produce methods of preparing tetanus, toxin major part is brought into blood system by blood flow, and be diffused into whole nerve pathway of health, absorb through body and enter nervous system, and act on central nervous system, suppress the release of neurotransmitter, block nerves and muscle are shown in the transmission of information, cause respiratory function disorderly, and then circulatory disturbance and hemodynamic upset occur, there is dehydration, the symptoms such as acidosis.Tetanus is generally 7-8 days incubation period, can be as short as 24 hours or reach several months, several years.Incubation period short person, prognosis is poorer.Patient's morbidity in injured latter 2 weeks of about 90%, there is tetanus signs in accidental patient after extracing in body the foreign body retained for many years.
Although tetanic sickness rate and case fatality rate significantly decline in developed country, remain a main public health problem in most of developing countries.In the poverty-stricken area, edge of China, tetanus is not yet completely controlled, and the tetanus neonatorum morbidity number of China's report was often average annual about several thousand people in recent years, and case fatality rate is about 15%.Chinese medicine thinks that primary disease is by after wound, or has infection focus, and lose in medical treatment, healthy energy is impaired, and ailment said due to cold or exposure is taken advantage of a loophole intrusion, and going from the exterior into the interior, caused by priming liver-wind.TCM prevention and cure is main control principle with inducing diaphoresis to dispel wind, suppressing the hyperactive liver relieving convulsion, counteracting toxic substances dredging collateral.
Application publication number CN103356879A(application number 201210105024.4) Chinese invention patent document disclose one and treat tetanic Chinese medicine formula, be made up of the crude drug of following weight proportion: Radix Astragali 12-18 gram, Radix Angelicae Sinensis 12-18 gram, Radix Rehmanniae 12-18 gram, Bombyx Batryticatus 12-18 gram, Ramulus Uncariae Cum Uncis 12-18 gram, Bulbus Fritillariae Thunbergii 12-18 gram, Radix Paeoniae Alba 22-28 gram, Rhizoma Typhonii (processed) 6-9 gram, scorpion powder 2.5-4 gram, Rhizoma Arisaematis (processed) 4-6 gram, Radix Glycyrrhizae 8-12 gram.Application publication number CN103272121A(application number 201310225561.7) Chinese invention patent document disclose one and treat tetanic Chinese medicine preparation, be made up of the crude drug of following weight portion: Herba Thesii 13-17 part, Rhizoma Polygonati Odorati 13-17 part, Rhizoma Bolbostematis 13-17 part, Radix Paeoniae Alba 13-17 part, Radix Astragali 10-14 part, Radix Rehmanniae 10-14 part, Herba Plantaginis 10-14 part, Radix Angelicae Sinensis 9-11 part, Scolopendra 9-11 part, Bombyx Batryticatus 9-11 part, Ramulus Uncariae Cum Uncis 6-8 part, Rhizoma Typhonii 6-8 part, Radix Saposhnikoviae 6-8 part, Scorpio 4-6 part, Rhizoma Arisaematis 4-6 part.Application publication number CN104435773A(application number 201410637496.3) Chinese invention patent document disclose one and treat tetanic Chinese medicine preparation, be made up of the crude drug of following weight portion: Rhizoma Arisaematis 15 parts, Zaocys 10 parts, Radix Clematidis 12 parts, Periostracum Cicadae 15 parts, Bombyx Batryticatus 20 parts, 15 parts, Rhizoma Gastrodiae, Radix Saposhnikoviae 18 parts, Radix Aconiti Kusnezoffii 15 parts, Flos Chrysanthemi 30 parts, Rhizoma Typhonii 9 parts, Scorpio 10 parts.
Current treatment tetanus mainly selects different Tri-Biocins according to different strain, it is main for carrying out vein instillation, operative treatment will be carried out if desired, Tri-Biocin has side effect, life-time service easily causes the immunity degradation of body, weaken the resistance against diseases of patient, and there is certain risk in operative treatment, and costly.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide that one is prepared simply, taking convenience, treat tetanic Chinese medicine preparation safely and effectively.This Chinese medicine preparation determined curative effect and having no side effect.
Technical scheme of the present invention is:
Treat tetanic Chinese medicine preparation, be prepared from by following bulk drugs, be weight portion: Boenninghausenia albiflora 11-16; Succus Bambusae 9-13; Shishou Air Bladder pseudosciaenae seu Acipenser 10-15; Periostracum Cicadae 7-10; Rhizoma Arisaematis 9-12; Herba Typhonii gigantei 10-15; Gekko Swinhonis 3-6; Radix Curcumae 12-16; Herba seu Radix Calanthes 10-17; Rhizoma Typhonii 8-11; Catechu 9-14; Rhizoma Tupistrae Chinensis 6-14; Radix Pseudostellariae 13-20; Herba Centellae 11-15; Herba basellae rubrae 9-16.
In preferred scheme, Boenninghausenia albiflora 12-15; Succus Bambusae 10-12; Shishou Air Bladder pseudosciaenae seu Acipenser 11-14; Periostracum Cicadae 8-9; Rhizoma Arisaematis 10-11; Herba Typhonii gigantei 11-14; Gekko Swinhonis 4-5; Radix Curcumae 13-15; Herba seu Radix Calanthes 12-15; Rhizoma Typhonii 9-10; Catechu 10-13; Rhizoma Tupistrae Chinensis 8-12; Radix Pseudostellariae 15-18; Herba Centellae 12-14; Herba basellae rubrae 11-14.
Be more preferably, Boenninghausenia albiflora 13.5; Succus Bambusae 11; Shishou Air Bladder pseudosciaenae seu Acipenser 12.5; Periostracum Cicadae 8.5; Rhizoma Arisaematis 10.5; Herba Typhonii gigantei 12.5; Gekko Swinhonis 4.5; Radix Curcumae 14; Herba seu Radix Calanthes 13.5; Rhizoma Typhonii 9.5; Catechu 11.5; Rhizoma Tupistrae Chinensis 10; Radix Pseudostellariae 16.5; Herba Centellae 13; Herba basellae rubrae 12.5.
Treat tetanic Chinese medicine preparation, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, and drains, is placed in the Pulvis Talci (Shishou Air Bladder pseudosciaenae seu Acipenser: Pulvis Talci=10:3) made popular, and slow fire heats, and when frying to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, porphyrize, for subsequent use; Gekko Swinhonis is placed in the rice made popular, slow fire heats, and stir-frying to rice is buff, and sieve removes rice, cools, grinds into powder, for subsequent use; Catechu is smashed to pieces, for subsequent use;
(2) Boenninghausenia albiflora, Herba Typhonii gigantei, Herba seu Radix Calanthes, Herba Centellae and Herba basellae rubrae are placed in traditional Chinese medicine drying device dry, take out, be ground into fine powder while hot, for subsequent use; Periostracum Cicadae is dried, porphyrize, for subsequent use;
(3) by Rhizoma Arisaematis, Radix Curcumae, Rhizoma Typhonii, Rhizoma Tupistrae Chinensis and Radix Pseudostellariae are placed in Chinese medicine pan, add the pure water (preferably adding the pure water of 7.5 times amount) of 6-9 times amount, soak under room temperature 1.5-2.5 hour (soaking 2 hours under being preferable over room temperature), intense fire heated and boiled, turn slow fire boiling twice, first time decocts 46-60 minute (preferably first time decocts 53 minutes), second time decocts 28-40 minute (preferably second time decocts 34 minutes), merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.25-1.28, vacuum drying gets dry extract powder, for subsequent use,
(4) the crude drug mixing after being processed step (1)-(3), crosses 50-80 mesh sieve (preferred mistake 65 mesh sieve), adds Succus Bambusae, making pellets by mixing medical powder with honey, make the pill of Semen Firmianae size, to obtain final product.
The preparation method of the tetanic medicine pill of above-mentioned treatment, preferred scheme is, the temperature of step (2) drying is 54-72 DEG C (preferred dry temperature is 59-67 DEG C, and the temperature of the drying be more preferably is 63 DEG C).
The preparation method of the tetanic medicine pill of above-mentioned treatment, preferred scheme is, the time of step (2) drying is 55-95 minute (the preferred dry time is 65-85 minute, and the time of the drying be more preferably is 75 minutes).
The preparation method of described water preparation is:
(1) Gekko Swinhonis is removed internal organs, clean, being placed in smokeless intense fire bakes micro-ly to two sides has focal spot, and taking-up cools, and grinds into powder, for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is placed in parch container, adds the Oleum Sesami of 20%, and slow fire heating roasting is golden yellow to both sides, and taking-up cools, and grinds into powder, for subsequent use;
(2) catechu is placed in air drier, and in 48-56 DEG C of dry 1-3 hour (being preferable over 52 DEG C of dryings 2 hours), taking-up cooled, and is ground into fine powder, for subsequent use; Succus Bambusae is through three aspect filtered through gauze, for subsequent use;
(3) Chinese medicine water extraction is adopted to extract the crude drug except step (1) and (2), first cold water is added to powder 3-5cm, soak, medical material is fully infiltrated, big fire heated and boiled 6-10 minute (preferred big fire heated and boiled 8 minutes), turn little fire and decoct three times slowly, first time decocts 40-56 minute (preferably first time decocts 48 minutes), second time decocts 38-46 minute (preferably second time decocts 42 minutes), third time decocts 16-30 minute (preferably third time decocts 23 minutes), merge three decocting liquids, filter, filtrate is for subsequent use;
(4) above-mentioned filtrate is concentrated into 1/2 of original volume, add the crude drug after step (1) and (2) process while hot, dry heat sterilization, cooling, fill, to obtain final product.
The preparation method of the tetanic Chinese medicinal aqua of above-mentioned treatment, preferred scheme is, the time of soaking in step (3) is 2-4 hour (the preferred time of soaking is 2.5-3.5 hour, and the time of the immersion be more preferably is 3 hours).
The preparation method of described tablet is:
(1) Gekko Swinhonis removing internal organs, clean, struts with bamboo chip, makes all flat straight, and be placed in the upper oven dry of smokeless literary composition, taking-up cools, and grinds into powder for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is placed in parch container, adds the Oleum Sesami of 20%, and slow fire heating roasting is golden yellow to both sides, and taking-up cools, and grinds into powder, for subsequent use;
(2) Succus Bambusae being evaporated to 85 DEG C of relative densities is the thick paste of 1.33-1.35, gets dry extract, mix, be together ground into dried cream powder with catechu in 75-85 DEG C of vacuum drying (being preferable over 80 DEG C of vacuum dryings), for subsequent use;
(3) by fully dry for the crude drug except step (1) and (2), be ground into fine powder, take mass concentration as the ethanol of 55%-75% be solvent (be preferably the ethanol of 65% with mass concentration be solvent), percolation is carried out according to percolation, percolation is stopped when the percolate collected is 20-24 times (percolate preferably collected is 22 times of raw material medicated powder amount) of raw material medicated powder amount, filter, filtrate recycling ethanol, being evaporated to 65 DEG C of relative densities is the thick paste of 1.15-1.20, spraying dry gets dry extract powder, for subsequent use;
(4) the crude drug mixing after step (1)-(3) being processed, cross 120-160 mesh sieve (preferred mistake 140 mesh sieve), add sucrose fine and magnesium stearate (raw material medicated powder: sucrose fine: magnesium stearate=5:1.3:1.1), fully mix, be pressed into tablet, obtain final product.
The preparation method of described powder is:
(1) Succus Bambusae being evaporated to 85 DEG C of relative densities is the thick paste of 1.33-1.35, gets dry extract in 80 DEG C of vacuum dryings, and porphyrize is for subsequent use;
(2) surplus stock medicine is placed in traditional Chinese medicine drying device, fully dry, pulverize into fine powder, mix with step (1) gained dried cream powder, cross 80-100 mesh sieve (preferred mistake 90 mesh sieve), carry out subpackage according to 5-8g/ bag (preferably according to 6.5g/ bag) metering, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Boenninghausenia albiflora: base is former: the herb of Rutaceae pine wind grass platymiscium Boenninghausenia albiflora.Nature and flavor: pungent, bitter, temperature.Function cures mainly: induce sweat preventing the attack (or recurrence) of malaria, promoting blood circulation to remove blood stasis, removing toxic substances.For malaria, cold, fever, bronchitis, traumatic injury; Traumatic hemorrhage is controlled in external, carbuncle furuncle infections.
Succus Bambusae: base is former: the Succus Bambusae flowed out through heating for grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Nature and flavor: sweet are cool.Gui Jing: enter the heart, stomach warp.Function cures mainly: the sliding expectorant of heat clearing away, relieving convulsion sharp key.Control middle wind-phlegm fan, lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.
Shishou Air Bladder pseudosciaenae seu Acipenser: base is former: be the Air Bladder pseudosciaenae seu Acipenser of Sciaenidae animal Carnis Pseudosciaenae or Carnis Pseudosciaenae.Nature and flavor: sweet are flat.Gui Jing: " book on Chinese herbal medicine is newly organized ": " enter kidney." function cures mainly: the kidney invigorating and essence nourishing, nourishes muscle arteries and veins, hemostasis, dissipating blood stasis, detumescence.Control spermatorrhea of suffering from a deficiency of the kidney, puerperal puerperal tetanus, tetanus, spit blood, metrorrhagia, wound hemorrhage, hemorrhoid.
Periostracum Cicadae: base is former: exuviae shell when this product is the nymph emergence of cicada Cryptotympana atrata Fabr..Pharmacological action: 1, anticonvulsant action; 2, sedation; 3, Periostracum Cicadae decoct can block the conduction of cat Superior cervical sympathetic ganglia, on adrenoreceptor and acetylcholine nerve depressor response then without impact.Nature and flavor: sweet, cold.Gui Jing: return lung, Liver Channel.Effect: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.Cure mainly: for anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, conjunctival congestion buckwheat hinders, convulsion with spasms, tetanus.
Rhizoma Arisaematis: base is former: be the tuber of aroid Rhizoma Arisaematis, arisaema amurense Maxim or Arisaema heterophyllum B1. etc.Chemical analysis: containing cupreol-D-Glucose glycoside and aminoacid.Nature and flavor: toil, temperature, poisonous.Gui Jing: enter lung, liver, spleen channel.Function cures mainly: drying dampness to eliminate phlegm, expelling wind for relieving convulsion, dispersing swelling and dissipating binds.Control middle wind-phlegm to mould, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus, dizziness due to wind-phlegm, sore throat, scrofula, carbuncle, falls and flutters injured, snake bite and insect sting.
Herba Typhonii gigantei: base is former: be the herb of aroid Herba Typhonii gigantei.Another name: Rhizoma Typhonium Gigantei (Rhizoma Typhonii), milk in vain attached, red male star, numb taro, the wild Rhizoma Pinelliae, Cor Gigeriae Galli are attached in vain.Nature and flavor: acrid, sweet, warm.Poisonous.Gui Jing: return stomach, Liver Channel.Function: drying dampness to eliminate phlegm, timid wind relieving convulsion, detoxicating and resolving stagnation of pathogens.Be applicable to the stagnant network of wind-phlegm, facial hemiparalysis, apoplexy abundant expectoration, aphasia hemiplegia, tetanus and headache due to cold-damp; External is used for sucutaneous nodule scrofula, venom.
Gekko Swinhonis: base is former: for Gekkonidae animal is without the entirety of web Gekko Swinhonis or other several Gekko Swinhonis.Pharmacological action: Gekko Swinhonis tissue fluid: Gekko Swinhonis is made leachate injection and treated some chronic disease, for neurasthenia, the intestines and stomach illness, dyspepsia, inappetence etc.Nature and flavor: " detailed outline ": " salty, cold, slightly poisonous." return through Liver Channel.Function cures mainly: expelling wind for relieving convulsion; Detoxicating and resolving stagnation of pathogens.Main severe and migratory arthralgia pain; Extremity are unsuccessful; Infantile convulsion; Tetanus, carbuncle scrofula; Leprosy; Tinea corporis; Dysphagic.
Radix Curcumae: base is former: be the tuber of zingiberaceous plant Rhizoma Curcumae Longae, Radix Curcumae or Rhizoma Curcumae.Nature and flavor: arduous, cool.Gui Jing: enter the heart, lung, Liver Channel.Function cures mainly: promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs.Control all pains of breast abdomen side of body rib, lose the heart demented, calentura coma, spit blood, epistaxis, hematuria, stranguria with blood, women's vicarious menstruation, jaundice.
Herba seu Radix Calanthes: base is former: be herb or the rhizome of the orchid family Calanthe plant calanthe.Composition: fresh rhizome is containing indoles and glucosides thereof: calanthe glycosides A, B, dihydro phenanthrene derivative, indican, the luxuriant and rich with fragrance alcohol of calanthe, Ryukyu's calanthe glycosides; Indoles alkaloid class: couroupitine A, indirubin etc.The property of medicine: pungent, micro-hardship, is slightly cold.Function cures mainly: heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.Cure mainly carbuncle, laryngopharynx swelling and pain, hemorrhoid, rheumatic arthralgia, traumatic injury.
Rhizoma Typhonii: base is former: this product is the dry tuber of aroid Herba Typhonii gigantei.Nature and flavor: pungent, temperature; Poisonous.Gui Jing: return stomach, Liver Channel.Function cures mainly: dispel the wind expectorant, and arresting convulsion is jerked, detoxicating and resolving stagnation of pathogens pain relieving.Stop up for middle wind-phlegm, facial hemiparalysis, language is puckery stuttering, and syncope due to accumulation of phlegm is had a headache, migraine and general headache, sore throat pharyngalgia, tetanus; External treatment scrofula sucutaneous nodule, venom.
Catechu: base is former: this product is going by branch, dry dry soft extracts of leguminous plant catechu.Gather winter skill, dry, removing crust, is chopped to bulk, decocts with water, concentrated, dry.Character: this product is square or irregular bulk, not of uniform size.Surface sepia or pitchy, smooth and slightly gloss.Matter is hard, and frangible, section is irregular, tool gloss. and have pore, wet has erosion.Nature and flavor: bitter, puckery, are slightly cold.Gui Jing: return lung meridian.Effect: removing dampness promoting tissue regeneration and ulcer healing.Cure mainly: for ulcer being unable to heal, eczema, aphtha, fall and flutter the pain of injury. traumatic hemorrhage.Pharmacological action: 1. to protect the liver, choleretic effect; 2. resisting pathogenic microbes effect; 3. suppress intestinal movement and anti-CaM antibody; 4. hypoglycemic activity.
Rhizoma Tupistrae Chinensis: base is former: be the band tuber stem of the orchid family Herminium plant musk orchid.The property of medicine: " Shanxi Chinese herbal medicine ": " sweet in the mouth, warm in nature." function cures mainly: kidney and spleen invigorating, promoting blood flow to regulate menstruation, removing toxic substances.Cure mainly dizzy insomnia, early whitening of beard and hair, loss of appetite, menoxenia, venom.
Radix Pseudostellariae: base is former: be the tuber of pinkwort pseudostellaria heterophylla.Chemical analysis: root is containing fructose, starch, Saponin.Nature and flavor: sweetness and bitterness, tepor.Gui Jing: " book on Chinese herbal medicine is new again ": " enter the heart, spleen, lung three warp." function cures mainly: tonifying the lung, strong board.Control cough due to deficiency of the lung, insufficiency of the spleen lack of appetite, cardiopalmus spontaneous perspiration, metal fatigue.Replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.For insufficiency of the spleen weak, after being ill thirsty, the lung of weakness, deficiency of both vital energy and Yin, spontaneous perspiration to make an uproar dry cough.
Herba Centellae: base is former: be dry herb or the whole herb with root of dicotyledon Umbelliferae Herba Centellae.Composition: containing the Triterpenoid of multiple α-balsam alcohol type, wherein have asiaticoside, thankuniside, isothankuniside, asiaticoside, Brahmoside, broken hot rice glycosides and Brahmic acid etc., and madasiatic acid.The property of medicine: bitter, acrid, cold.Return liver,spleen,kidney warp.Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Be the long-lived medicine of Asians, can refresh oneself by beneficial brain.Research shows to have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.Also effective in cure to leprosy, ulcer, there is activation to blood purification and immunity, because it can stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, alleviate mental fatigue; Also can blood pressure lowering, treatment hepatopathy etc.
Herba basellae rubrae: base is former: Basellaceae Herba basellae rubrae platymiscium Herba basellae rubrae, with all herbal medicine.Nature and flavor: sweet, light, cool.Gui Jing: GUIXIN, liver, spleen, large and small intestinal warp.Function cures mainly: heat-clearing and toxic substances removing, bone-setting pain stopping.For appendicitis, dysentery, constipation, cystitis; Fracture is controlled in external, traumatic injury, traumatic hemorrhage, burn and scald.Glutinous sliding material in Herba basellae rubrae is become to be grouped into mucoprotein etc. by water soluble pectin, and mucoproteinly have the effect suppressing sugar to absorb, and is " the good fortune dish " of diabetics.
Chinese medicine preparation scientific formula provided by the invention, the preparation method of various dosage form is simple, products obtained therefrom taking convenience, safe and effective.In addition, excellent results of the present invention also shows:
1,the present invention uses theory of Chinese medical science to analyze prescription composition, and according to each physicochemical property of flavour of a drug ingredient and the result of study of pharmacological action, research obtains the preparation method of reasonable, stable active component.
2,the present invention has loose wind heat, separates the effect such as spasm, tranquillizing and allaying excitement, effectively prevents and treats tetanus, having obvious inhibitory action to clostridium tetani;
3,product effective ingredient of the present invention scatters and disappears few, and curative effect is high, has no side effect, cheap, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat tetanic Chinese medicine preparation, be prepared from by following bulk drugs, be weight portion (40g/ part): Boenninghausenia albiflora 11 parts; Succus Bambusae 9 parts; 10 parts, Shishou Air Bladder pseudosciaenae seu Acipenser; Periostracum Cicadae 7 parts; Rhizoma Arisaematis 9 parts; Herba Typhonii gigantei 10 parts; Gekko Swinhonis 3 parts; Radix Curcumae 12 parts; Herba seu Radix Calanthes 10 parts; Rhizoma Typhonii 8 parts; 9 parts, catechu; Rhizoma Tupistrae Chinensis 6 parts; Radix Pseudostellariae 13 parts; Herba Centellae 11 parts; Herba basellae rubrae 9 parts.
The preparation method for the treatment of tetanic medicine pill is:
(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, and drains, is placed in the Pulvis Talci (Shishou Air Bladder pseudosciaenae seu Acipenser: Pulvis Talci=10:3) made popular, and slow fire heats, and when frying to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, porphyrize, for subsequent use; Gekko Swinhonis is placed in the rice made popular, slow fire heats, and stir-frying to rice is buff, and sieve removes rice, cools, grinds into powder, for subsequent use; Catechu is smashed to pieces, for subsequent use;
(2) Boenninghausenia albiflora, Herba Typhonii gigantei, Herba seu Radix Calanthes, Herba Centellae and Herba basellae rubrae are placed in traditional Chinese medicine drying device in 54 DEG C of dryings 55 minutes, take out, be ground into fine powder while hot, for subsequent use; Periostracum Cicadae is dried, porphyrize, for subsequent use;
(3) Rhizoma Arisaematis, Radix Curcumae, Rhizoma Typhonii, Rhizoma Tupistrae Chinensis and Radix Pseudostellariae are placed in Chinese medicine pan, add the pure water of 6 times amount, soak 1.5 hours under room temperature, intense fire heated and boiled, turn slow fire boiling twice, first time decocts 46 minutes, and second time decocts 28 minutes, merges twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.25-1.28, and vacuum drying gets dry extract powder, for subsequent use;
(4) the crude drug mixing after being processed step (1)-(3), crosses 50 mesh sieves, adds Succus Bambusae, making pellets by mixing medical powder with honey, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained medicine pill of the present invention is: every day three times, each 8-10 ball, 3 days courses for the treatment of.
Model case: Wei XX, female, 36 years old, patient was to our hospital on May 20th, 2010.Patient's readme: before 6 days in next way home by bike, collide in a street and people, fall down, arm is stabbed by the iron nail on road, after going home to carry out simple dressing, does not arrive hospital and breaks cold pin.After this within the 3rd day, occur breathing, suffering of speaking, gnathospasma, muscle spasm is twitched, and my institute of accompanying of layman checks treatment.Check: entire patient's muscle spasm, abdominal muscle, dorsal muscles are nervous, and extremity hypermyotonia, muscular strength is normal.Be diagnosed as tetanus.
Take the present embodiment gained and treat tetanic medicine pill, instructions of taking: every day three times, each 8-10 ball, 3 days courses for the treatment of.Take medicine two courses for the treatment of, whole-body muscle spasm is obviously alleviated, and other symptom is greatly improved
A course for the treatment of of following the service, patient's self-induction is fully recovered.
embodiment 2treat tetanic Chinese medicine preparation, be prepared from by following bulk drugs, be weight portion (10g/ part): Boenninghausenia albiflora 16 parts; Succus Bambusae 13 parts; 15 parts, Shishou Air Bladder pseudosciaenae seu Acipenser; Periostracum Cicadae 10 parts; Rhizoma Arisaematis 12 parts; Herba Typhonii gigantei 15 parts; Gekko Swinhonis 6 parts; Radix Curcumae 16 parts; Herba seu Radix Calanthes 17 parts; Rhizoma Typhonii 11 parts; 14 parts, catechu; Rhizoma Tupistrae Chinensis 14 parts; Radix Pseudostellariae 20 parts; Herba Centellae 15 parts; Herba basellae rubrae 16 parts.
The preparation method for the treatment of tetanic Chinese medicinal aqua is:
(1) Gekko Swinhonis is removed internal organs, clean, being placed in smokeless intense fire bakes micro-ly to two sides has focal spot, and taking-up cools, and grinds into powder, for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is placed in parch container, adds the Oleum Sesami of 20%, and slow fire heating roasting is golden yellow to both sides, and taking-up cools, and grinds into powder, for subsequent use;
(2) catechu is placed in air drier, and in 52 DEG C of dryings 2 hours, taking-up cooled, and is ground into fine powder, for subsequent use; Succus Bambusae is through three aspect filtered through gauze, for subsequent use;
(3) Chinese medicine water extraction is adopted to extract the crude drug except step (1) and (2), first add cold water to powder 3-5cm, soak 3 hours, medical material is fully infiltrated, big fire heated and boiled 8 minutes, turn little fire and decoct three times slowly, first time decocts 48 minutes, and second time decocts 42 minutes, third time decocts 23 minutes, merge three decocting liquids, filter, filtrate is for subsequent use;
(4) above-mentioned filtrate is concentrated into 1/2 of original volume, add the crude drug after step (1) and (2) process while hot, dry heat sterilization, cooling, fill, to obtain final product.
The instructions of taking of gained Chinese medicinal aqua of the present invention is: every day three times, each 120-150mL, 3 days courses for the treatment of.
embodiment 3treat tetanic Chinese medicine preparation, be prepared from by following bulk drugs, be weight portion (30g/ part): Boenninghausenia albiflora 12 parts; Succus Bambusae 10 parts; 11 parts, Shishou Air Bladder pseudosciaenae seu Acipenser; Periostracum Cicadae 8 parts; Rhizoma Arisaematis 10 parts; Herba Typhonii gigantei 11 parts; Gekko Swinhonis 4 parts; Radix Curcumae 13 parts; Herba seu Radix Calanthes 12 parts; Rhizoma Typhonii 9 parts; 10 parts, catechu; Rhizoma Tupistrae Chinensis 8 parts; Radix Pseudostellariae 15 parts; Herba Centellae 12 parts; Herba basellae rubrae 11 parts.
The preparation method for the treatment of tetanic Chinese medicinal tablet is:
(1) Gekko Swinhonis removing internal organs, clean, struts with bamboo chip, makes all flat straight, and be placed in the upper oven dry of smokeless literary composition, taking-up cools, and grinds into powder for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is placed in parch container, adds the Oleum Sesami of 20%, and slow fire heating roasting is golden yellow to both sides, and taking-up cools, and grinds into powder, for subsequent use;
(2) Succus Bambusae being evaporated to 85 DEG C of relative densities is the thick paste of 1.33-1.35, gets dry extract, mix, be together ground into dried cream powder with catechu in 80 DEG C of vacuum dryings, for subsequent use;
(3) by fully dry for the crude drug except step (1) and (2), be ground into fine powder, take mass concentration as the ethanol of 65% be solvent, carry out percolation according to percolation, when the percolate collected is 22 times of raw material medicated powder amount, stop percolation, filter, filtrate recycling ethanol, being evaporated to 65 DEG C of relative densities is the thick paste of 1.15-1.20, and spraying dry gets dry extract powder, for subsequent use;
(4) the crude drug mixing after being processed step (1)-(3), crosses 140 mesh sieves, adds sucrose fine and magnesium stearate (raw material medicated powder: sucrose fine: magnesium stearate=5:1.3:1.1), fully mix, be pressed into tablet, to obtain final product.
The instructions of taking of gained Chinese medicinal tablet of the present invention is: every day three times, each 4-6 sheet, 3 days courses for the treatment of.
Model case: field XX, man, 53 years old, patient was to our hospital in JIUYUE in 2013 17 days.Recently there is weak, headache without obvious inducement in patient, the root of the tongue such as to harden at the symptom.Patient is other in ditch before one week is scratched shank by one block of iron sheet got rusty, and patient has carried out simple cleaning and wrapping to wound voluntarily, does not arrive regular hospital and breaks cold pin.Soon patient feels not quite the thing, and occurs above-mentioned symptom.Check: patient's root of the tongue hardens, difficulty in opening mouth, gnathospasma, with the symptom such as weak, dizzy, headache, stiffness of the neck, is diagnosed as tetanus.
Take the present embodiment gained and treat tetanic Chinese medicinal tablet, instructions of taking: every day three times, each 4-6 sheet, 3 days courses for the treatment of.After patient takes two courses for the treatment of, stiffness of the neck disappears, and mandibular joint folding recovers normal, and other symptom is also eliminated, and continues to take a course for the treatment of and is consolidated, and patients symptomatic disappears, and self-induction is fully recovered.Pay a return visit after half a year, without recurrence.
embodiment 4treat tetanic Chinese medicine preparation, be prepared from by following bulk drugs, be weight portion (20g/ part): Boenninghausenia albiflora 15 parts; Succus Bambusae 12 parts; 14 parts, Shishou Air Bladder pseudosciaenae seu Acipenser; Periostracum Cicadae 9 parts; Rhizoma Arisaematis 11 parts; Herba Typhonii gigantei 14 parts; Gekko Swinhonis 5 parts; Radix Curcumae 15 parts; Herba seu Radix Calanthes 15 parts; Rhizoma Typhonii 10 parts; 13 parts, catechu; Rhizoma Tupistrae Chinensis 12 parts; Radix Pseudostellariae 18 parts; Herba Centellae 14 parts; Herba basellae rubrae 14 parts.
The preparation method for the treatment of tetanic Chinese powder medicine is:
(1) Succus Bambusae being evaporated to 85 DEG C of relative densities is the thick paste of 1.33-1.35, gets dry extract in 80 DEG C of vacuum dryings, and porphyrize is for subsequent use;
(2) surplus stock medicine is placed in traditional Chinese medicine drying device, fully dry, pulverize into fine powder, mix with step (1) gained dried cream powder, cross 90 mesh sieves, carry out subpackage according to the metering of 6.5g/ bag, to obtain final product.
The instructions of taking of gained Chinese powder medicine of the present invention is: every day three times, each 1-2 bag, 3 days courses for the treatment of.
embodiment 5treat tetanic Chinese medicine preparation, be prepared from by following bulk drugs, be weight portion (25g/ part): Boenninghausenia albiflora 13.5 parts; Succus Bambusae 11 parts; 12.5 parts, Shishou Air Bladder pseudosciaenae seu Acipenser; Periostracum Cicadae 8.5 parts; Rhizoma Arisaematis 10.5 parts; Herba Typhonii gigantei 12.5 parts; Gekko Swinhonis 4.5 parts; Radix Curcumae 14 parts; Herba seu Radix Calanthes 13.5 parts; Rhizoma Typhonii 9.5 parts; 11.5 parts, catechu; Rhizoma Tupistrae Chinensis 10 parts; Radix Pseudostellariae 16.5 parts; Herba Centellae 13 parts; Herba basellae rubrae 12.5 parts.
The preparation method for the treatment of tetanic medicine pill is:
(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, and drains, is placed in the Pulvis Talci (Shishou Air Bladder pseudosciaenae seu Acipenser: Pulvis Talci=10:3) made popular, and slow fire heats, and when frying to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, porphyrize, for subsequent use; Gekko Swinhonis is placed in the rice made popular, slow fire heats, and stir-frying to rice is buff, and sieve removes rice, cools, grinds into powder, for subsequent use; Catechu is smashed to pieces, for subsequent use;
(2) Boenninghausenia albiflora, Herba Typhonii gigantei, Herba seu Radix Calanthes, Herba Centellae and Herba basellae rubrae are placed in traditional Chinese medicine drying device in 63 DEG C of dryings 75 minutes, take out, be ground into fine powder while hot, for subsequent use; Periostracum Cicadae is dried, porphyrize, for subsequent use;
(3) Rhizoma Arisaematis, Radix Curcumae, Rhizoma Typhonii, Rhizoma Tupistrae Chinensis and Radix Pseudostellariae are placed in Chinese medicine pan, add the pure water of 7.5 times amount, soak 2 hours under room temperature, intense fire heated and boiled, turn slow fire boiling twice, first time decocts 53 minutes, and second time decocts 34 minutes, merges twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.25-1.28, and vacuum drying gets dry extract powder, for subsequent use;
(4) the crude drug mixing after being processed step (1)-(3), crosses 65 mesh sieves, adds Succus Bambusae, making pellets by mixing medical powder with honey, make the pill of Semen Firmianae size, to obtain final product.
The instructions of taking of gained medicine pill of the present invention is: every day three times, each 8-10 ball, 3 days courses for the treatment of.
test example 1gained of the present invention treats the clinical practice of tetanic Chinese medicine preparation (embodiment 5):
In November ,-2013 in March, 2010, screen 346 routine tetanus patients in 4 hospitals, wherein male patient 183 example, female patient 163 example, the age 17-56 year, the course of disease is at 1-7 days.All patients are divided into experimental group and matched group at random, and two groups of patients there are no significant in age, sex and the state of an illness etc. difference (P > 0.05), has comparability.Wherein experimental group takes products obtained therefrom of the present invention, instructions of taking: every day three times, each 8-10 ball, 3 days courses for the treatment of.Matched group takes other medicines (as conventional medication such as erythromycin octadecanoate sheet, QUANTIANMA JIAONANG, erythromycin ethylsuccinate capsules).Observe three courses for the treatment of of treatment altogether.Curative effect determinate standard: cure: the clinical symptoms such as tic, spasm all disappear, affected part wound healing; Take a turn for the better: clinical symptoms and sign are obviously improved; Invalid: clinical symptoms and sign are without improvement or increase the weight of.(total effective rate=cure rate+improvement rate) therapeutic outcome is as shown in table 1.
Table 1: experimental group and matched group patient treatment outcome
Therapeutic effect: experimental group cures 157 examples (71.4%), 59 examples that take a turn for the better (26.8%), invalid 4 examples (1.8%), total effective rate 98.2%.Successful is better than matched group.
By Boenninghausenia albiflora, Succus Bambusae, Shishou Air Bladder pseudosciaenae seu Acipenser, Periostracum Cicadae, Rhizoma Arisaematis, Herba Typhonii gigantei, Gekko Swinhonis, Radix Curcumae, Herba seu Radix Calanthes, Rhizoma Typhonii, catechu, Rhizoma Tupistrae Chinensis and Radix Pseudostellariae etc., totally 15 taste primary raw material medicines are formulated in the present invention.Fang Zhong, Boenninghausenia albiflora induces sweat preventing the attack (or recurrence) of malaria, promoting blood circulation to remove blood stasis; The sliding expectorant of Succus Bambusae heat clearing away, relieving convulsion sharp key; Shishou Air Bladder pseudosciaenae seu Acipenser the kidney invigorating and essence nourishing, nourishes muscle; Periostracum Cicadae falls apart wind heat extraction, spasmolytic; Herba Typhonii gigantei drying dampness to eliminate phlegm, timid wind relieving convulsion, detoxicating and resolving stagnation of pathogens; ; Radix Curcumae promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs; Herba Centellae heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Full side's compatibility, plays loose wind heat altogether, separates effect of spasm, tranquillizing and allaying excitement.Experimental group treats three courses for the treatment of, and total effective rate is 98.2%, and matched group is only 80.2%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat tetanic Chinese medicine preparation, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Boenninghausenia albiflora 11-16; Succus Bambusae 9-13; Shishou Air Bladder pseudosciaenae seu Acipenser 10-15; Periostracum Cicadae 7-10; Rhizoma Arisaematis 9-12; Herba Typhonii gigantei 10-15; Gekko Swinhonis 3-6; Radix Curcumae 12-16; Herba seu Radix Calanthes 10-17; Rhizoma Typhonii 8-11; Catechu 9-14; Rhizoma Tupistrae Chinensis 6-14; Radix Pseudostellariae 13-20; Herba Centellae 11-15; Herba basellae rubrae 9-16.
2. the tetanic Chinese medicine preparation for the treatment of as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Boenninghausenia albiflora 12-15; Succus Bambusae 10-12; Shishou Air Bladder pseudosciaenae seu Acipenser 11-14; Periostracum Cicadae 8-9; Rhizoma Arisaematis 10-11; Herba Typhonii gigantei 11-14; Gekko Swinhonis 4-5; Radix Curcumae 13-15; Herba seu Radix Calanthes 12-15; Rhizoma Typhonii 9-10; Catechu 10-13; Rhizoma Tupistrae Chinensis 8-12; Radix Pseudostellariae 15-18; Herba Centellae 12-14; Herba basellae rubrae 11-14.
3. the tetanic Chinese medicine preparation for the treatment of as claimed in claim 1, is characterized in that, be prepared from by following bulk drugs, be weight portion: Boenninghausenia albiflora 13.5; Succus Bambusae 11; Shishou Air Bladder pseudosciaenae seu Acipenser 12.5; Periostracum Cicadae 8.5; Rhizoma Arisaematis 10.5; Herba Typhonii gigantei 12.5; Gekko Swinhonis 4.5; Radix Curcumae 14; Herba seu Radix Calanthes 13.5; Rhizoma Typhonii 9.5; Catechu 11.5; Rhizoma Tupistrae Chinensis 10; Radix Pseudostellariae 16.5; Herba Centellae 13; Herba basellae rubrae 12.5.
4. the tetanic Chinese medicine preparation of the treatment as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) Shishou Air Bladder pseudosciaenae seu Acipenser is cleaned, and drains, is placed in the Pulvis Talci (Shishou Air Bladder pseudosciaenae seu Acipenser: Pulvis Talci=10:3) made popular, and slow fire heats, and when frying to tympanites pine bubble, take out, sieve removes Pulvis Talci, cools, porphyrize, for subsequent use; Gekko Swinhonis is placed in the rice made popular, slow fire heats, and stir-frying to rice is buff, and sieve removes rice, cools, grinds into powder, for subsequent use; Catechu is smashed to pieces, for subsequent use;
(2) Boenninghausenia albiflora, Herba Typhonii gigantei, Herba seu Radix Calanthes, Herba Centellae and Herba basellae rubrae are placed in traditional Chinese medicine drying device dry, take out, be ground into fine powder while hot, for subsequent use; Periostracum Cicadae is dried, porphyrize, for subsequent use;
(3) by Rhizoma Arisaematis, Radix Curcumae, Rhizoma Typhonii, Rhizoma Tupistrae Chinensis and Radix Pseudostellariae are placed in Chinese medicine pan, add the pure water (preferably adding the pure water of 7.5 times amount) of 6-9 times amount, soak under room temperature 1.5-2.5 hour (soaking 2 hours under being preferable over room temperature), intense fire heated and boiled, turn slow fire boiling twice, first time decocts 46-60 minute (preferably first time decocts 53 minutes), second time decocts 28-40 minute (preferably second time decocts 34 minutes), merge twice decocting liquid, filter, filtrate reduced in volume to 75 DEG C relative density is the thick paste of 1.25-1.28, vacuum drying gets dry extract powder, for subsequent use,
(4) the crude drug mixing after being processed step (1)-(3), crosses 50-80 mesh sieve (preferred mistake 65 mesh sieve), adds Succus Bambusae, making pellets by mixing medical powder with honey, make the pill of Semen Firmianae size, to obtain final product.
5. the preparation method of the tetanic medicine pill for the treatment of according to claim 4, is characterized in that, the temperature of step (2) drying is 54-72 DEG C (preferred dry temperature is 59-67 DEG C, and the temperature of the drying be more preferably is 63 DEG C).
6. the preparation method of the tetanic medicine pill for the treatment of according to claim 4, is characterized in that, the time of step (2) drying is 55-95 minute (the preferred dry time is 65-85 minute, and the time of the drying be more preferably is 75 minutes).
7. the tetanic Chinese medicine preparation of the treatment as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable water preparation, preparation method is as follows:
(1) Gekko Swinhonis is removed internal organs, clean, being placed in smokeless intense fire bakes micro-ly to two sides has focal spot, and taking-up cools, and grinds into powder, for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is placed in parch container, adds the Oleum Sesami of 20%, and slow fire heating roasting is golden yellow to both sides, and taking-up cools, and grinds into powder, for subsequent use;
(2) catechu is placed in air drier, and in 48-56 DEG C of dry 1-3 hour (being preferable over 52 DEG C of dryings 2 hours), taking-up cooled, and is ground into fine powder, for subsequent use; Succus Bambusae is through three aspect filtered through gauze, for subsequent use;
(3) Chinese medicine water extraction is adopted to extract the crude drug except step (1) and (2), first cold water is added to powder 3-5cm, soak, medical material is fully infiltrated, big fire heated and boiled 6-10 minute (preferred big fire heated and boiled 8 minutes), turn little fire and decoct three times slowly, first time decocts 40-56 minute (preferably first time decocts 48 minutes), second time decocts 38-46 minute (preferably second time decocts 42 minutes), third time decocts 16-30 minute (preferably third time decocts 23 minutes), merge three decocting liquids, filter, filtrate is for subsequent use;
(4) above-mentioned filtrate is concentrated into 1/2 of original volume, add the crude drug after step (1) and (2) process while hot, dry heat sterilization, cooling, fill, to obtain final product.
8. the preparation method of the tetanic Chinese medicinal aqua for the treatment of according to claim 7, is characterized in that, the time of soaking in step (3) is 2-4 hour (the preferred time of soaking is 2.5-3.5 hour, and the time of the immersion be more preferably is 3 hours).
9. the tetanic Chinese medicine preparation of the treatment as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable tablet, preparation method is as follows:
(1) Gekko Swinhonis removing internal organs, clean, struts with bamboo chip, makes all flat straight, and be placed in the upper oven dry of smokeless literary composition, taking-up cools, and grinds into powder for subsequent use; Shishou Air Bladder pseudosciaenae seu Acipenser is placed in parch container, adds the Oleum Sesami of 20%, and slow fire heating roasting is golden yellow to both sides, and taking-up cools, and grinds into powder, for subsequent use;
(2) Succus Bambusae being evaporated to 85 DEG C of relative densities is the thick paste of 1.33-1.35, gets dry extract, mix, be together ground into dried cream powder with catechu in 75-85 DEG C of vacuum drying (being preferable over 80 DEG C of vacuum dryings), for subsequent use;
(3) by fully dry for the crude drug except step (1) and (2), be ground into fine powder, take mass concentration as the ethanol of 55%-75% be solvent (be preferably the ethanol of 65% with mass concentration be solvent), percolation is carried out according to percolation, percolation is stopped when the percolate collected is 20-24 times (percolate preferably collected is 22 times of raw material medicated powder amount) of raw material medicated powder amount, filter, filtrate recycling ethanol, being evaporated to 65 DEG C of relative densities is the thick paste of 1.15-1.20, spraying dry gets dry extract powder, for subsequent use;
(4) the crude drug mixing after step (1)-(3) being processed, cross 120-160 mesh sieve (preferred mistake 140 mesh sieve), add sucrose fine and magnesium stearate (raw material medicated powder: sucrose fine: magnesium stearate=5:1.3:1.1), fully mix, be pressed into tablet, obtain final product.
10. the tetanic Chinese medicine preparation of the treatment as described in claim 1-3, is characterized in that, be made into pharmaceutically acceptable powder, preparation method is as follows:
(1) Succus Bambusae being evaporated to 85 DEG C of relative densities is the thick paste of 1.33-1.35, gets dry extract in 80 DEG C of vacuum dryings, and porphyrize is for subsequent use;
(2) surplus stock medicine is placed in traditional Chinese medicine drying device, fully dry, pulverize into fine powder, mix with step (1) gained dried cream powder, cross 80-100 mesh sieve (preferred mistake 90 mesh sieve), carry out subpackage according to 5-8g/ bag (preferably according to 6.5g/ bag) metering, to obtain final product.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991781A (en) * | 2009-08-26 | 2011-03-30 | 栗素琴 | Traditional Chinese medicine preparation for treating tetanus |
| CN102526393A (en) * | 2012-01-16 | 2012-07-04 | 崔永奎 | Traditional Chinese medicine for treating tetanus |
| CN103272121A (en) * | 2013-06-07 | 2013-09-04 | 刘建飞 | Tetanus treatment traditional Chinese medicine preparation |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991781A (en) * | 2009-08-26 | 2011-03-30 | 栗素琴 | Traditional Chinese medicine preparation for treating tetanus |
| CN102526393A (en) * | 2012-01-16 | 2012-07-04 | 崔永奎 | Traditional Chinese medicine for treating tetanus |
| CN103272121A (en) * | 2013-06-07 | 2013-09-04 | 刘建飞 | Tetanus treatment traditional Chinese medicine preparation |
Non-Patent Citations (2)
| Title |
|---|
| 王景洪等: "《张学文医学求索集》", 31 January 1996, 陕西科学技术出版社 * |
| 王瑞麟: "《中药顺歌》", 30 April 2013, 河南科学技术出版社 * |
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