CN104906398A - Traditional Chinese medicine for treating liver and kidney yin deficiency and turbid sputum syndrome type hypertension - Google Patents

Abstract

The invention belongs to the technical field of medicine and particularly relates to traditional Chinese medicine for treating liver and kidney yin deficiency and turbid sputum syndrome type hypertension. The traditional Chinese medicine for treating liver and kidney yin deficiency and turbid sputum syndrome type hypertension is prepared from, by weight, 11-19 parts of Chinese wolfberry fruits, 11-19 parts of eclipta, 11-19 parts of mulberries, 6-14 parts of black sesame, 11-19 parts of prepared rehmannia roots, 11-19 parts of concha haliotidis, 6-14 parts of tribulus terrestris, 6-14 parts of apocynum venetum, 6-14 parts of gastrodia elata, 6-14 parts of uncaria, 4-8 parts of pinellia ternata, 4-8 parts of rhizoma arisaematis, 4-8 parts of Chinese honey locust, 4-8 parts of rhizoma acori graminei, 6-14 parts of agastache rugosus, 6-14 parts of eupatorium, 6-14 parts of roots of common peony, 6-14 parts of roots of red-rooted salvia, 6-14 parts of ligusticum wallichii, 6-14 parts of peach kernels, 6-14 parts of safflower carthamus, 5-13 parts of periostracum cicada, 5-13 parts of folium mori, 5-13 parts of chrysanthemums, 11-19 parts of tuber fleeceflower stems, 6-14 parts of cortex albiziae, 6-14 parts of wild jujube seeds, 4-8 parts of fructus evodiae and 4-8 parts of liquorice. The traditional Chinese medicine for treating liver and kidney yin deficiency and turbid sputum syndrome type hypertension can obviously reduce systolic pressure, diastolic pressure and mean arterial pressure of patients while western medicine reduces pressure basically, obviously avoid the clinical symptoms of patients like headache, dizziness, insomnia, tinnitus and annoyance and irritability, and improve the quality of life of patients.

Description

One is treated the hepatic and renal YIN deficiency and to be held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant

Technical field

The invention belongs to medical art, be specifically related to the one treatment hepatic and renal YIN deficiency and hold concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant.

Background technology

Essential hypertension (Essential hyPertension, EH) is clinical common cardiovascular disease, increases the clinical syndrome for main manifestations with systemic arterial blood pressure persistence.Often cause infringement and the nonfunction of the target organs such as the heart, brain, kidney, have that prevalence is high, complication is many, disability rate high, its sickness rate is in raising trend year by year, serious threat human health.Hypertension is the most important risk factors of cardiovascular diseases of current Chinese population, the Acute coronary event of at least 20% in crowd, the cerebral infarction event of nearly 40% and 59% hemorrhagic apoplexy event be attributable to hypertension.In China, hypertensive sickness rate the 1950's is 5.1%, and the seventies is 7.73%, and the nineties is 11.88%, and the whole nation at present nearly 1.6 hundred million people suffers from hypertension; And 30.2% is only had to hypertensive awareness, treatment rate only has 24.7%, and control rate only has 6.1%, and this shows that the hypertensive preventing and controlling of China are shouldered heavy responsibilities.

Western medical treatment hypertension is mainly through reducing blood pressure steadily, lastingly and remaining in normal range, and the good blood pressure of long-term control, effectively can prevent target organ damage.Western medicine of depressurization is wide in variety, antihypertensive effect is obvious, also selects by drug combination the therapeutic scheme meeting patient, is conducive to effectively controlling blood pressure.Weak point is, long-term taking depressor, has certain drug side effect, and not obvious for the improvement of hypertension simultaneous phenomenon, weak effect in the life quality improving patient.

Causing hypertensive reason a lot, is first that feelings will is forfeited one's integrity, as not smooth, angry in mood with psychentonia etc., in addition, cross pungent addicted to tobacco and wine, delicious food is thick greasy, all can cause that the liver failing to maintain the normal flow of QI, liver-yang are excessively high, expectorant turbid on disturb and the pathological changes such as the hepatic and renal YIN deficiency, and cause hypertensive generation.The melancholy,anxiety and overstrain impairment of the spleen or work with one's mind excessively sad, heart spleen is impaired, on the one hand can because of expectorant turbid on disturb, it is strongly fragrant that soil stops up wood, and liver is lost bar and reaches and form hypertension; On the one hand deficiency of spleen-YIN, blood lose moisten foster, impairment of purifying and descending function of the lung, transverse invasion of hyperactive liver-QI and hypertension induced.This class hypertension, the often double card seeing heart spleen, as headache, dizziness, insomnia, tinnitus, susceptible to lose temper due to restlessness etc.Western medicine is used for treating hypertension, often only reduces blood pressure, and improves not obvious for other clinical symptoms.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, there is provided one to treat the hepatic and renal YIN deficiency to hold concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, under the prerequisite of doctor trained in Western medicine basis Treatment of Hypertension, significantly can reduce systolic pressure, diastolic pressure, the mean arterial pressure of patient, obviously improve patient clinical symptom, as headache, dizziness, insomnia, tinnitus, susceptible to lose temper due to restlessness etc., improve the life quality of patient.

The present invention is achieved through the following technical solutions:

One is treated the hepatic and renal YIN deficiency and to be held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Lycii 11-19 part, Herba Ecliptae 11-19 part, Fructus Mori 11-19 part, Semen Sesami Nigrum 6-14 part, Radix Rehmanniae Preparata 11-19 part, Concha Haliotidis 11-19 part, Fructus Tribuli 6-14 part, Herba Apocyni veneti 6-14 part, Rhizoma Gastrodiae 6-14 part, Ramulus Uncariae Cum Uncis 6-14 part, Rhizoma Pinelliae 4-8 part, Rhizoma Arisaematis 4-8 part, Fructus Gleditsia 4-8 part, Rhizoma Acori Graminei 4-8 part, Herba Pogostemonis 6-14 part, Herba Eupatorii 6-14 part, Radix Paeoniae Rubra 6-14 part, Radix Salviae Miltiorrhizae 6-14 part, Rhizoma Chuanxiong 6-14 part, Semen Persicae 6-14 part, Flos Carthami 6-14 part, Periostracum Cicadae 5-13 part, Folium Mori 5-13 part, Flos Chrysanthemi 5-13 part, Caulis Polygoni Multiflori 11-19 part, Cortex Albiziae 6-14 part, Semen Ziziphi Spinosae 6-14 part, Fructus Evodiae 4-8 part, Radix Glycyrrhizae 4-8 part.

Preferably, the above-mentioned treatment hepatic and renal YIN deficiency is held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Lycii 13-17 part, Herba Ecliptae 13-17 part, Fructus Mori 13-17 part, Semen Sesami Nigrum 8-12 part, Radix Rehmanniae Preparata 13-17 part, Concha Haliotidis 13-17 part, Fructus Tribuli 8-12 part, Herba Apocyni veneti 8-12 part, Rhizoma Gastrodiae 8-12 part, Ramulus Uncariae Cum Uncis 8-12 part, Rhizoma Pinelliae 5-7 part, Rhizoma Arisaematis 5-7 part, Fructus Gleditsia 5-7 part, Rhizoma Acori Graminei 5-7 part, Herba Pogostemonis 8-12 part, Herba Eupatorii 8-12 part, Radix Paeoniae Rubra 8-12 part, Radix Salviae Miltiorrhizae 8-12 part, Rhizoma Chuanxiong 8-12 part, Semen Persicae 8-12 part, Flos Carthami 8-12 part, Periostracum Cicadae 7-11 part, Folium Mori 7-11 part, Flos Chrysanthemi 7-11 part, Caulis Polygoni Multiflori 13-17 part, Cortex Albiziae 8-12 part, Semen Ziziphi Spinosae 8-12 part, Fructus Evodiae 5-7 part, Radix Glycyrrhizae 5-7 part.

Preferred, the above-mentioned treatment hepatic and renal YIN deficiency is held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Lycii 15 parts, Herba Ecliptae 15 parts, Fructus Mori 15 parts, Semen Sesami Nigrum 10 parts, Radix Rehmanniae Preparata 15 parts, Concha Haliotidis 15 parts, Fructus Tribuli 10 parts, Herba Apocyni veneti 10 parts, 10 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 10 parts, the Rhizoma Pinelliae 6 parts, Rhizoma Arisaematis 6 parts, 6 parts, Fructus Gleditsia, Rhizoma Acori Graminei 6 parts, Herba Pogostemonis 10 parts, Herba Eupatorii 10 parts, Radix Paeoniae Rubra 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Chuanxiong 10 parts, 10 parts, Semen Persicae, 10 parts, Flos Carthami, Periostracum Cicadae 9 parts, 9 parts, Folium Mori, Flos Chrysanthemi 9 parts, Caulis Polygoni Multiflori 15 parts, Cortex Albiziae 10 parts, Semen Ziziphi Spinosae 10 parts, Fructus Evodiae 6 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: the hepatic and renal YIN deficiency is held concurrently the turbid upper illiteracy type hypertension of expectorant, and disease is seen: dizzy of a specified duration endlessly heaviness of the head as being covered, rotates depending on thing, uncomfortable in chestly does evil, vomiting sputum, visual deterioration, two dryness and uneasy feeling of the eye, sleep forgetful less, susceptible to lose temper due to restlessness, nose heave foot is light, and xerostomia, tinnitus, tongue is greasy in vain, stringy and rolling pulse.

Applicant finds that clinical middle essential hypertension is more common in old people, dialectically belongs to the hepatic and renal YIN deficiency more, and excessive rising of liver-YANG is held concurrently the turbid upper illiteracy of expectorant.Pathogenesis is: old deficiency of the kidney, the liver failing to be nourished, so that deficiecny of liver-YIN, caused by liver and kidney deficiency, and brain is not filled, YANG-orifices failing to be nourished, and the moon sun not processed, excessive rising of liver-YANG is sent out as primary disease; And modern way of life changes, old people's obesity crowd is very many, and diet delicious food is thick greasy at ordinary times, and the turbid interior life of expectorant, the clear key of upper illiteracy is sent out as primary disease.Therefore, should with nourishing the liver and kidney, suppressing the hyperactive liver and subsiding YANG, refreshment of eliminating phlegm for resuscitation is the rule for the treatment of.

Fructus Lycii: nature and flavor: sweet is flat.Return liver, kidney channel.Function cures mainly: nourishing the liver and kidney, replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat is quenched one's thirst, blood deficiency and yellow complexion, and blurred vision is failed to understand.1. " book on Chinese herbal medicine converges and says ": " enter few cloudy, the meridian of Foot-JUE YIN of foot." 2. " book on Chinese herbal medicine is through separating ": " enter kidney meridian, heart channel of Hand-Shaoyin." 3. " key medicine divides agent ": " and enter liver, stomach two warp, double enter lung meridian.”

Herba Ecliptae: nature and flavor: sweet, sour, cold.Return kidney, Liver Channel.Function cures mainly: nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.1. Tang Materia Medica: " main dysentery.Acupuncture skin ulcer is sent out, and big vast blood can not the person of stopping apply it; Juice is coated with sends out an eyebrow, raw speed and numerous." 2. " Japan hanako materia medica ": " logical small intestinal, applies all skin ulcers and silkworm Guo for evacuation of pus, hemostasis." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " teeth consolidating, crow palpus, washes nine kinds of hemorrhoid." 4. " detailed outline ": " black beard and hair, kidney tonifying is cloudy.”

Fructus Mori: nature and flavor: sweet, sour, cold.GUIXIN, liver, kidney channel.Function cures mainly: YIN nourishing of enriching blood, and promotes the production of body fluid and moisturizes.For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation.

Semen Sesami Nigrum: nature and flavor: sweet, flat.Gui Jing: return liver, kidney, large intestine channel.Function cures mainly: invigorating the liver and kidney, benefiting essence-blood, and intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.

Radix Rehmanniae Preparata: nature and flavor: sweet, tepor.Return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.1. " pearl sac ": " enrich blood greatly empty not enough, promoting blood circulation, physical strength profiting." 2. Wang Haogu: " main seat and for rising, order coloured glaze coloured glaze is without finding." 3. " detailed outline ": " fill out bone marrow, longue meat, promoting generation of vital essence and blood, tonifying five ZANG-organs, internal injury are not enough, and promoting blood circulation, Li Er, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, tire produces all kinds of diseases and ailments." 4. " Bencao Congxin ": " sharp blood vessels, tonification is Kidney-Yin, hearing-improing and eyesight improving, hair color crow palpus for kidney nourishing water, packing bone marrow.Again can tonifying spleen-yin, only chronic diarrhea, controls impairment caused by overstrain migratory arthralgia, cloudyly loses heating, dry cough phlegmatic cough, dyspnea with shortness of breath, emptiness of the stomach feels hungry, and pox demonstrate,proves no pus of having a guilty conscience, and shin stock is ached after being ill, the anxious pain of umbilicus abdomen in puerperal, and sense card the moon loses, losslessly just close, all kinds of dynamic blood, all hepatic and renal YIN deficiency, deficient all kinds of diseases and ailments are strengthening renal yin to inhibit predominant yang medicine.”

The Rhizoma Pinelliae: nature and flavor: pungent, temperature; Poisonous.Return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, vomiting regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus; Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.1. " herbal classic ": " therapeutic method to keep the adverse QI flowing downwards, laryngopharynx swells and ache, and dizziness breast is swollen, cough with dyspnea, borborygmus, hidroschesis for main typhoid fever cold and heat, hardness in the epigastrium." 2. " not Lu ": " the full knot of diabetes with polydipsia as the prominent symptom abdomen chest and diaphragm expectorant heat, cough with dyspnea, the hard painful abdominal mass of acute pain in the epigastrium, seasonal epidemic pathogens vomiting; Subduing inflammation, induced abortion, treats dull yellowish colored skin, happy damp appearance.Raw make us telling, ripely to make us down." 3. " property of medicine opinion ": " anti-nausea, go expectorant in the heart full, lower lung qi, master coughs knot for expectorant saliva, appetite promoting and the spleen strengthening.New survivor rub be coated with carbuncle do not disappear, can tumor wart be removed.The deficiency of vital energy and have mental disorder, adds and uses it.”

Rhizoma Arisaematis: nature and flavor: bitter, pungent, temperature; Poisonous.Return lung, liver, spleen channel.Function cures mainly: drying dampness to eliminate phlegm, expellings wind and relieving convulsion, mass dissipating and swelling eliminating.For pertinacious phlegm cough, dizziness due to wind-phlegm, middle wind-phlegm is stopped up, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, tetanus.Life uses external treatment carbuncle, snake bite and insect sting.1. " herbal classic ": " main pained, cold and heat, stagnation of QI, gathers, fullness in the epigastrium especially referring to the abcess of the abdomen in ancient times, muscle and tendon injury, flaccidity, arrests slow, dredging water passages." 2. " not Lu ": " and except uncontrolled urination, dizziness due to wind pathogen." 3. " property of medicine opinion ": " control dizziness due to wind pathogen nystagmus, main hernia abdominal mass enterodynia, disease during typhoid fever, reinforcing YIN-essence.”

Fructus Gleditsia: nature and flavor: pungent, temperature, micro-poison.Return lung, large intestine channel.Function cures mainly: dispel the wind expectorant, except noxious dampness, and parasite killing.Control apoplexy facial hemiparalysis, wind syndrome of head is had a headache, cough phlegm dyspnea, and discharging fresh blood stool, dysentery is kept silent mouth, carbuncle inguinal bubo, skin ulcer tinea mange." Bencao Tujing ": " dispelling wind gas.”

Rhizoma Acori Graminei: nature and flavor: pungent, bitter, temperature.GUIXIN, stomach warp.Function cures mainly: removing dampness is whetted the appetite, eliminating phlegm of having one's ideas straightened out, refreshment Fructus Alpiniae Oxyphyllae.Not hungry for gastral cavity painful abdominal mass, a mouthful dysentery of keeping silent, coma epilepsy, forgetful deafness.1. " herbal classic ": " happy hole, tonifying five ZANG-organs, logical nine orifices, improve visual and auditory acuity, goes out speech for main anemofrigid-damp arthralgia, cough with dyspnea." 2. " not Lu ": " warming intestines and stomach, only normal urination, extremity arthralgia chiefly caused by damp pathogen, must not bend and stretch, children's's pyrexial malaria, and body accumulated heat is not understood, and can do to bathe soup for main deafness, carbuncle skin ulcer.Audition improvement order, beneficial intelligence." 3. " property of medicine opinion ": " wind syndrome of head, under tear, kills parasites for dispelling the wind and dampness pathogens insensitive impediment, tinnitus, controls malignant boil scabies scabies.”

Herba Pogostemonis: nature and flavor: pungent, tepor.Enter lung, spleen, stomach warp.Function cures mainly: fast gas, and in, ward off dirty, damp eliminating.Cure cold heat-damp in summer, cold and heat, and headache, breast gastral cavity painful abdominal mass is vexed, and vomiting is had loose bowels, malaria, dysentery, halitosis.1. " not Lu ": " treat edema due to wind pathogen poison swollen, remove bad odor, treat cholera, pained." 2. " Bencao Tujing ": " controlling taste tells inverse, is the medicine wanted most." 3. " pearl sac ": " benefit defends gas, and stomach reinforcing gas, enters diet, controls again and tells inverse cholera.”

Herba Eupatorii: nature and flavor: pungent, flat.Return spleen, stomach, lung meridian.Function cures mainly: removing dampness by means of aromatics, and appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.1. " herbal classic ": " main dredging water passages, kills diseases due to noxious agents produced by various parasites." 2. " opinion processed by the public big gun of Zhai ": " hemopoietic, regulating QI is with flourish." 3. " not Lu ": " except the expectorant stasis of blood in the heart.”

Concha Haliotidis: nature and flavor: salty, cold.Return Liver Channel.Function cures mainly: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.1. " not Lu ": " argument is hidden from view pain, optic atrohic blindness." 2. " Haiyao Bencao, Oversea Materia Medica ": " main optic atrophy, liver lung-wind syndrome heat, hectic fever due to YIN-deficiency labor pole." 3. " detailed outline ": " logical five types of stranguria." 4. " Bencao Congxin ": " more infections cellulitis." 5. " book on Chinese herbal medicine asks former ": " anal fistula is controlled in softening the hard mass, nourishing kidney." 6. " Shandong Chinese herbal medicine handbook ": " town liver, improving eyesight are controlled dizzy.”

Fructus Tribuli: nature and flavor: pungent, bitter, tepor; Slightly poisonous.Return Liver Channel.Function cures mainly: suppressing the hyperactive liver resolving depression, promoting blood circulation by removing wind, and improving eyesight is antipruritic.Dizzy for having a headache, distending pain in the chest and hypochondrium, breast closes acute mastitis, cataract, rubella pruritus.1. " book on Chinese herbal medicine is new again ": " QI invigorating is reduced phlegm for town liver-wind, removing fire from the liver, wet dissipation removing blood stasis, eliminating carbuncle cellulitis, sore-toxin dispersing." 2. " Nanjing medicinal herbs among the people ": " control red-white dysentery." 3. " medicine will is planted in Jiangsu ": " control hypochondriac pain, treat all infectionss, go wind to invigorate blood circulation.”

Herba Apocyni veneti: nature and flavor: sweet; Micro-hardship; Cool in nature.Return Liver Channel.Function cures mainly: heat clearing away suppressing the hyperactive liver; Inducing diuresis to remove edema.Main hypertension; Dizzy; Headache; Cardiopalmus; Insomnia; Edema urine water.1. " medicine will is planted in Jiangsu ": " milk can healing of wound." 2. " illustrated handbook planted by middle traditional Chinese medicines ": " tender leaf, steams and fries kneading offspring tea, have refrigerant reducing internal heat, and prevents function that is dizzy and heart tonifying." 3. " Shaanxi Chinese herbal medicine ": " refrigerant pathogenic fire purging, heart tonifying diuresis, blood pressure lowering.Control heart disease, hypertension, neurasthenia, nephritis edema.”

Rhizoma Gastrodiae: nature and flavor: sweet is flat.Return Liver Channel.Function cures mainly: suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.1. " herbal classic ": " main bad odor, takes physical strength profiting for a long time, long cloudy fertile strong." 2. " not Lu ": " subduing inflammation, lower distention and fullness, hernia, hematochezia." 3. " property of medicine opinion ": " control cold air insensitive impediment, paralysis is slow unsuccessful, and how in a trance language is, shies mental confusion more." 4. " Japan hanako materia medica ": " aid yang qi, mend five kinds of strain and seven kinds of impairment, promoting blood circulation, has one's ideas straightened out." 5. " Kaibao Bencao ": " main all rheumatism numbness, spasm of the limbs, children's's acute infantile convulsion, frightened gas, sharp waist knee joint, strong biceps." 6. Zhang Yuansu: " control the empty dizziness and headache of wind." 7. " book on Chinese herbal medicine converges and says ": " dizzy void is revolved, the strong convulsion of epilepsy for main wind syndrome of head, headache, and extremity contraction is anxious, and language has some setbacks, all apoplexy, wind-phlegm.”

Ramulus Uncariae Cum Uncis: nature and flavor: sweet is cool.Return liver, pericardium channel.Function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension.1. " not Lu ": " main children's's cold and heat, infantile convulsion." 2. " property of medicine opinion ": " main children's's night crying due to fright in infant ， Chi Zong heat is stopped up." 3. " Japan hanako materia medica ": " control infantile convulsive seizure due to fright erythroderma of newborn." 4. " detailed outline ": " the large number of people revolves dizzy, suppressing liver-wind, and except heat in the heart, children's's infantile tic is suffered from abdominal pain, and sends out macule." 5. " book on Chinese herbal medicine is levied and wanted ": " relaxing muscles and tendons removes dizzy, therapeutic method to keep the adverse QI flowing downwards alleviating distention in middle-JIAO." 6. " book on Chinese herbal medicine is stated ": " control paralysis due to windstroke, facial hemiparalysis, and all brothers' migratory arthralgia caused by wind pain, podomere contraction is anxious.Control again many years ago gout paralysis, spasm of muscles and vessels is had a pain endlessly person.”

Periostracum Cicadae: nature and flavor: sweet, cold.Return lung, Liver Channel.Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.1. " not Lu ": " main children's's epilepsy; The main chronic dysentery of ash clothes." 2. " property of medicine opinion ": " control children's's high fever infantile convulsion from head to foot, doublely to quench the thirst." 3. supplement to the Herbal: " grind, a money an ancient type of spoon, well flower water clothes, main mute disease." 4. amplification on Canon of Materia Medica: " control blurred vision nebula.Decocting shell juice again, controlling children's, to go out skin ulcer rash unhappy." 5. " detailed outline ": " control phlegm-accumulating vertigo, skin wind heat, varioliform exanthema is had an itch, tetanus and treatment toxic swelling skin ulcer, and adult's aphonia, children's's lockjaw sky hangs, frightened night cry of crying, swelling of the vulva.”

Folium Mori: nature and flavor: sweet, bitter, cold.Return lung, Liver Channel.Function cures mainly: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, liver heat removing and eyesight improving.For anemopyretic cold, lung-heat type cough, dizziness headache, conjunctival congestion is dim-sighted.1. " book on Chinese herbal medicine covers bamboo fish trap ": " boil soup, wash eye and remove lacrimation induced by wind pathogen, consumer edema foot floats, the therapeutic method to keep the adverse QI flowing downwards, sharp joint." 2. " detailed outline ": " control consumptive fever cough, improving eyesight, long hair." 3. " Bencao Congxin ": " grow dry, removing heat from blood, hemostasis.”

Flos Chrysanthemi: nature and flavor: sweet, bitter, is slightly cold.Return lung, Liver Channel.Function cures mainly: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.1. " herbal classic ": " lead all dizziness due to wind, swell and ache, order wish is de-, lacrimation, the dead flesh of skin, aversion to wind arthralgia chiefly caused by damp pathogen, sharp vim and vigour." 2. " not Lu ": " treating lumbago goes happy, and except irritable feverish sensation in the chest, peace the intestines and stomach, sharp five pulse conditions of ZANG-organs, adjusts extremity." 3. TAO Hong-Jing: " Flos Chrysanthemi: main air is dizzy." 4. " property of medicine opinion ": " hot wind syndrome of head can be controlled revolve and fall down to the ground, brain bone pain, all wind orders are with it dissipated." 5. " Japan hanako materia medica ": " sharp blood vessels, control extremity urticaria, vexed, chest and diaphragm is stopped up vexed, and carbuncle is malicious, headache; Do pillow improving eyesight." 6. " pearl sac ": " support bleeding of eye." 7. " medication heart method ": " removing nebula film, improving eyesight." 8. Wang Haogu: " main deficiency of liver-QI." 9. " detailed outline is picked up any lost article from the road ": " specially enter sun point.Control all dizziness due to wind, alcoholic intoxication furuncle swells.”

Caulis Polygoni Multiflori: nature and flavor: sweet micro-hardship is flat.GUIXIN, Liver Channel.Function cures mainly: nourish heart, and calms the nerves, and dredging collateral dispels the wind.Control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.1. " book on Chinese herbal medicine is new again ": " promoting blood circulation, controls impairment caused by overstrain for invigorating middle warmer gas, network of passing through." 2. " book on Chinese herbal medicine justice ": " control to pacify less night and sleep." 3. " decoction pieces is newly joined ": " nourishing the liver and kidney, only sweating due to debility, hypnosis of calming the nerves.”

Cortex Albiziae: nature and flavor: sweet, flat.GUIXIN, liver, lung meridian.Function cures mainly: resolving stagnation for tranquilization, promoting blood circulation and detumescence.For irritability, melancholy insomnia, lung abscess skin ulcer swells, and falls and flutters the pain of injury.1. " herbal classic ": " main settling five organs, and will make us happy carefree." 2. Nanchuan " conventional Chinese herbal medicine handbook ": " control that the motive is restless, insomnia and clonic spasm of the muscle.”

Semen Ziziphi Spinosae: nature and flavor: sweet, sour is flat.Return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.1. " herbal classic ": " main trusted subordinate's cold and heat, pathogens agglomerating gas gathers, painful limbs, arthralgia chiefly caused by damp pathogen." 2. " not Lu ": " main vexatious insomnia, umbilicus is pain up and down, and blood turns chronic diarrhea, sweating due to debility excessive thirst, invigorating middle warmer, the liver benefiting gas, and hard muscles and bones helps cloudy gas, makes us fertile strong." 3. " property of medicine opinion ": " main muscles and bones wind is fried end and is taken it as soup." 4. supplement to the Herbal: " many rawly to make of sleeping, must not sleep and fry." 5. Wang Haogu: " and control milk-livered sleeplessness, cold also, fry clothes; Control somnolence due to gallbladder-excess, heat also, use by life." 6. " book on Chinese herbal medicine converges and says ": " astringing QI is calmed the nerves, and flourish muscle supports marrow, stomach function regulating activating the spleen." 7. " book on Chinese herbal medicine is new again ": " suppressing the hyperactive liver is regulated the flow of vital energy, nourishing lung-YIN, warming middle-JIAO dampness removing, astringing QI hidroschesis, and beneficial will is breathed out surely, hearing-improing and eyesight improving.”

Fructus Evodiae: nature and flavor: pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Function cures mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension." detailed outline ": " dissipating depression of QIization is stagnant.Control acid regurgitation, the cloudy sputum that falls is had a headache, insidious stomachache, hernia, dysentery, mouthpiece's aphtha.”

Radix Glycyrrhizae: nature and flavor: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Fang Xie:

Monarch drug: Fructus Lycii, Herba Ecliptae, Fructus Mori, Semen Sesami Nigrum, Radix Rehmanniae Preparata share nourishing the liver and kidney, yin nourishing replenishing essence, brain must be filled, and clear key must be supported; The Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Acori Graminei, Herba Pogostemonis, Herba Eupatorii share eliminating phlegm and ward off and dirtyly to have one's ideas straightened out, and are monarch drug altogether.

Ministerial drug: Concha Haliotidis, Fructus Tribuli, Herba Apocyni veneti, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis share suppressing the hyperactive liver and subsiding YANG, calming wind and dredging collateral is ministerial drug.

Adjuvant drug: Periostracum Cicadae, Folium Mori, Flos Chrysanthemi share liver heat removing and eyesight improving, Caulis Polygoni Multiflori, Cortex Albiziae, Semen Ziziphi Spinosae share the mind tranquilizing and the heart calming that nourishes heart, and Fructus Evodiae controls headache due to JUE YIN disorder, and can treat hypertension, be adjuvant drug simultaneously altogether.

Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

In a word, essential hypertension is more common in old people, and the dialectical hepatic and renal YIN deficiency that belongs to is held concurrently the turbid upper illiteracy of expectorant more.Pathogenesis is: old deficiency of the kidney, the liver failing to be nourished, so that deficiecny of liver-YIN, caused by liver and kidney deficiency, and brain is not filled, YANG-orifices failing to be nourished, and the moon sun not processed, excessive rising of liver-YANG is sent out as primary disease; And modern way of life changes, old people's obesity crowd is very many, and diet delicious food is thick greasy at ordinary times, and the turbid interior life of expectorant, the clear key of upper illiteracy is sent out as primary disease." Ling Shu Miraculous Pivot or Divine Axis defends gas " thinks " deficiency of the upper causing dizziness ", and " Ling Shu Miraculous Pivot or Divine Axis mouth is asked " is said: " QI of the upper portion of the body being insufficient, empty sensation in the brain; ear is bitter ring for it, suffering from the head tilted down feebly, blurring of vision ", and " Ling Shu Miraculous Pivot or Divine Axis sea opinion " thinks " brain being the marrow sea ", and " deficiency of marrow-reservoir, then vertigo and tinnitus ", think that a dizzy disease is based on void.Han dynasty Zhang Zhongjing thinks that phlegm retention is one of reason of dizzy morbidity, and for later age, the discussion of " dizziness must be caused by phlegm " provides theoretical basis.Reuse Fructus Lycii, Herba Ecliptae, Fructus Mori, Semen Sesami Nigrum, Radix Rehmanniae Preparata in this feet bath recipe with nourishing the liver and kidney, yin nourishing replenishing essence, brain must be filled, and clear key must be supported; Be equipped with the suppressing the hyperactive liver and subsiding YANG medicines such as Concha Haliotidis, Fructus Tribuli, Herba Apocyni veneti, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis, cloudy gas is raw, and the yang-energy of rising is restricted, YIN and YANG in a relative equilibrium.The Rhizoma Pinelliae, Rhizoma Arisaematis, Fructus Gleditsia, Rhizoma Acori Graminei, Herba Pogostemonis, Herba Eupatorii share eliminating phlegm and ward off and dirtyly to have one's ideas straightened out; In addition, the simultaneous phenomenons such as the conjunctival congestion caused for hypertension liver-yang hyperactivity, vexed insomnia and headache, adopt Periostracum Cicadae, Folium Mori, Flos Chrysanthemi to share liver heat removing and eyesight improving, Caulis Polygoni Multiflori, Cortex Albiziae, Semen Ziziphi Spinosae share the mind tranquilizing and the heart calming that nourishes heart, and Fructus Evodiae controls headache due to JUE YIN disorder.We's compatibility is reasonable, and all medicines share plays YIN nourishing Liver and kidney, suppressing the hyperactive liver and subsiding YANG altogether, and eliminating phlegm wards off dirty effect of having one's ideas straightened out.

Beneficial effect of the present invention is as follows:

Observe by experiment, adopt the treatment group patient of Chinese medicine foot bath of the present invention to reduce (systolic pressure, diastolic blood pressure values, pulse pressure difference, mean arterial pressure) at blood pressure after treatment and be better than matched group, antihypertensive effect is obvious, and group difference has statistical significance (P<0.05).Compare between group before the headache of patient's cardinal symptom, dizzy, Insomnia therapy, the equal not statistically significant of difference (P>0.05), after treating one week, the clinical simultaneous phenomenon of hypertension such as treatment group headache, dizzy, insomnia, tinnitus and irritable improves obviously, and be obviously better than matched group, difference has statistical significance (P<0.01), illustrates that Chinese medicine foot bath of the present invention obviously can improve the many clinical malaise symptoms of hypertension.According to the standard of curative effect evaluation, statistical analysis can show that the total effective rate for the treatment of group is 98.67%, matched group total effective rate 76.0%, and treatment group curative effect is better than matched group (P<0.05).

The treatment hepatic and renal YIN deficiency of the present invention is held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, under the prerequisite of doctor trained in Western medicine basis Treatment of Hypertension, significantly can reduce systolic pressure, diastolic pressure, the mean arterial pressure of patient, obviously improve patient clinical symptom, as headache, dizziness, insomnia, tinnitus and irritable etc., improve the life quality of patient, reduce the dosage of Western medicine.And feet bath recipe foot bath easy, inexpensive, imitate good.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

One is treated the hepatic and renal YIN deficiency and to be held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of following raw material of Chinese medicine medicine:

Fructus Lycii 15g, Herba Ecliptae 15g, Fructus Mori 15g, Semen Sesami Nigrum 10g, Radix Rehmanniae Preparata 15g, Concha Haliotidis 15g, Fructus Tribuli 10g, Herba Apocyni veneti 10g, Rhizoma Gastrodiae 10g, Ramulus Uncariae Cum Uncis 10g, Rhizoma Pinelliae 6g, Rhizoma Arisaematis 6g, Fructus Gleditsia 6g, Rhizoma Acori Graminei 6g, Herba Pogostemonis 10g, Herba Eupatorii 10g, Radix Paeoniae Rubra 10g, Radix Salviae Miltiorrhizae 10g, Rhizoma Chuanxiong 10g, Semen Persicae 10g, Flos Carthami 10g, Periostracum Cicadae 9g, Folium Mori 9g, Flos Chrysanthemi 9g, Caulis Polygoni Multiflori 15g, Cortex Albiziae 10g, Semen Ziziphi Spinosae 10g, Fructus Evodiae 6g, Radix Glycyrrhizae 6g.

Embodiment 2

One is treated the hepatic and renal YIN deficiency and to be held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of following raw material of Chinese medicine medicine:

Fructus Lycii 13g, Herba Ecliptae 17g, Fructus Mori 13g, Semen Sesami Nigrum 12g, Radix Rehmanniae Preparata 13g, Concha Haliotidis 17g, Fructus Tribuli 8g, Herba Apocyni veneti 12g, Rhizoma Gastrodiae 8g, Ramulus Uncariae Cum Uncis 12g, Rhizoma Pinelliae 5g, Rhizoma Arisaematis 7g, Fructus Gleditsia 5g, Rhizoma Acori Graminei 7g, Herba Pogostemonis 8g, Herba Eupatorii 12g, Radix Paeoniae Rubra 8g, Radix Salviae Miltiorrhizae 12g, Rhizoma Chuanxiong 8g, Semen Persicae 12g, Flos Carthami 8g, Periostracum Cicadae 11g, Folium Mori 7g, Flos Chrysanthemi 11g, Caulis Polygoni Multiflori 13g, Cortex Albiziae 12g, Semen Ziziphi Spinosae 8g, Fructus Evodiae 7g, Radix Glycyrrhizae 5g.

Embodiment 3

One is treated the hepatic and renal YIN deficiency and to be held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of following raw material of Chinese medicine medicine:

Fructus Lycii 17g, Herba Ecliptae 13g, Fructus Mori 17g, Semen Sesami Nigrum 8g, Radix Rehmanniae Preparata 17g, Concha Haliotidis 13g, Fructus Tribuli 12g, Herba Apocyni veneti 8g, Rhizoma Gastrodiae 12g, Ramulus Uncariae Cum Uncis 8g, Rhizoma Pinelliae 7g, Rhizoma Arisaematis 5g, Fructus Gleditsia 7g, Rhizoma Acori Graminei 5g, Herba Pogostemonis 12g, Herba Eupatorii 8g, Radix Paeoniae Rubra 12g, Radix Salviae Miltiorrhizae 8g, Rhizoma Chuanxiong 12g, Semen Persicae 8g, Flos Carthami 12g, Periostracum Cicadae 7g, Folium Mori 11g, Flos Chrysanthemi 7g, Caulis Polygoni Multiflori 17g, Cortex Albiziae 8g, Semen Ziziphi Spinosae 12g, Fructus Evodiae 5g, Radix Glycyrrhizae 7g.

Embodiment 4

One is treated the hepatic and renal YIN deficiency and to be held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of following raw material of Chinese medicine medicine:

Fructus Lycii 11g, Herba Ecliptae 19g, Fructus Mori 11g, Semen Sesami Nigrum 14g, Radix Rehmanniae Preparata 11g, Concha Haliotidis 19g, Fructus Tribuli 6g, Herba Apocyni veneti 14g, Rhizoma Gastrodiae 6g, Ramulus Uncariae Cum Uncis 14g, Rhizoma Pinelliae 5g, Rhizoma Arisaematis 8g, Fructus Gleditsia 5g, Rhizoma Acori Graminei 8g, Herba Pogostemonis 6g, Herba Eupatorii 14g, Radix Paeoniae Rubra 6g, Radix Salviae Miltiorrhizae 14g, Rhizoma Chuanxiong 6g, Semen Persicae 14g, Flos Carthami 6g, Periostracum Cicadae 13g, Folium Mori 5g, Flos Chrysanthemi 13g, Caulis Polygoni Multiflori 11g, Cortex Albiziae 14g, Semen Ziziphi Spinosae 6g, Fructus Evodiae 8g, Radix Glycyrrhizae 4g.

Embodiment 5

One is treated the hepatic and renal YIN deficiency and to be held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, is made up of following raw material of Chinese medicine medicine:

Fructus Lycii 19g, Herba Ecliptae 11g, Fructus Mori 19g, Semen Sesami Nigrum 6g, Radix Rehmanniae Preparata 19g, Concha Haliotidis 11g, Fructus Tribuli 14g, Herba Apocyni veneti 6g, Rhizoma Gastrodiae 14g, Ramulus Uncariae Cum Uncis 6g, Rhizoma Pinelliae 8g, Rhizoma Arisaematis 4g, Fructus Gleditsia 8g, Rhizoma Acori Graminei 5g, Herba Pogostemonis 14g, Herba Eupatorii 5g, Radix Paeoniae Rubra 14g, Radix Salviae Miltiorrhizae 6g, Rhizoma Chuanxiong 14g, Semen Persicae 6g, Flos Carthami 14g, Periostracum Cicadae 5g, Folium Mori 13g, Flos Chrysanthemi 5g, Caulis Polygoni Multiflori 19g, Cortex Albiziae 6g, Semen Ziziphi Spinosae 14g, Fructus Evodiae 4g, Radix Glycyrrhizae 8g.

Carried out clinical pharrnacokinetics test to Chinese medicine of the present invention, Details as Follows:

1 object of study

1.1. research method

1.1.1 case source

Collect 150 routine primary hypertension patients altogether and include research in.

1.1.2 case selection standard: meet the diagnosis of doctor trained in Western medicine essential hypertension, Syndrome in TCM belongs to the hepatic and renal YIN deficiency and to hold concurrently the patient of the turbid upper illiteracy type of expectorant.

1.1.3 Diagnosing Hypertension standard

Western medicine diagnose standard: hypertension diagnosis and classification were with reference to basic unit's version " Chinese hypertension prevention and control guide " in 2009, when not using antihypertensive, non-three measurements on the same day, systolic pressure >=140mmHg and (or) diastolic pressure) >=90mmHg, diagnosable is hypertension.Patient previously has history of hypertension, takes antihypertensive at present, though blood pressure is lower than 140/90mmhg, also should be diagnosed as hypertension.Systolic pressure >=140mmHg's and diastolic pressure >=90mmHg is systole and relaxing period (two phase) hypertension, systolic pressure >=14OmmHg and diastolic pressure <90mmHg is isolated systolic hypertension; Systolic pressure <14OmmHg and diastolic pressure >=90mmHg is isolated diastolic hypertension.Hypertension grading: 1 grade of hypertension: systolic pressure 140-159mmHg and/or diastolic pressure 90-99mmHg; 2 grades of hypertension: systolic pressure 160-179mmHg and/or diastolic pressure 100-1O9mmHg; 3 grades of hypertension: systolic pressure >=18OmmHg and/or diastolic pressure >=ll0mmHg.When systolic pressure and diastolic pressure adhere to different classification separately, using higher rank as standard.

Tcm diagnosis standard: " new Chinese medicine Hypertension guideline of clinical investigations " that tcm diagnosis and pattern of syndrome diagnostic criteria are promulgated with reference to Ministry of Public Health in 1993, choose its Chinese medical discrimination and belong to the hepatic and renal YIN deficiency and to hold concurrently the turbid upper illiteracy type of expectorant, its diagnostic criteria is as follows: dizzy of a specified duration endlessly, heaviness of the head as being covered, rotates depending on thing, uncomfortable in chestly to do evil, vomiting sputum, visual deterioration, two order dry color grace are puckery, sleep less forgetful, susceptible to lose temper due to restlessness, nose heave foot is light, xerostomia, tinnitus, tongue is greasy in vain, stringy and rolling pulse.

1.1.4 case inclusive criteria:

L () meets above-mentioned diagnostic criteria I, II grade of hyperpietic;

(2) above-mentioned liver-Yang sthenia type tcm diagnosis standard person is met;

(3) age is at the sex of 40-75 one full year of life;

(4) patient's informed consent, consenting subjects;

1.1.5 exclusion standard:

L () is known to drug allergy person any in drugs;

(2) gestation, women breast-feeding their children and the person that takes contraceptive;

(3) age is more than 75 years old or be less than 40 years old;

(4) do not agree to participate in this experimenter;

(5) secondary hypertension person;

Kainogenesis myocardial infarction or apoplexy person in (6) 6 months;

(7) heart failure acute attack person when being admitted to hospital;

(8) cardiac function V level person; Hepatic and kidney function obstacle person;

(9) blood patient;

(10) diabetic peripheral neuropathy, skin of lower extremity breakage or the infected;

(11) Chinese and western medicine diagnostic criteria person is not met.

1.1.6 experimenter stops, exits the condition of clinical trial:

The reason that the researcher participating in clinical trial stops test and and the relation of clinical trial will conscientious record; Bright

True record midway experimenter is unwilling to proceed clinical trial, proposes the reason exiting clinical trial, and itemized record

Evaluation index during termination.

L () experimenter oneself requires to exit;

(2) according to the suggestion of researcher, if continue test will be unfavorable for the health of experimenter, as there is anaphylaxis

Or serious adverse reaction, test should be stopped.

(3) therapist is not carried out in strict accordance with scheme.

1.1.7 the standard rejected:

L () does not meet inclusive criteria and is not included in person by mistake.

(2) experimenter's compliance poor, occur serious adverse events, occur complication or special physiological change should not continue

Reception test, by the case of unblinding, voluntarily bolter etc. in blind trial, is all considered as the case that comes off.Itemized record,

Analyze the reason occurring untoward reaction.Should in conjunction with concrete condition process during statistical analysis: as there is untoward reaction person, count the statistics of untoward reaction; Because of invalid and self falling person, count efficacy analysis; Test does not adhere to person's course for the treatment of, depending on self falling.

(3) in therapeutic process, controlling of blood pressure is undesirable, and patient's malaise symptoms is without alleviation.

2 designs

2.1. design: adopt randomised controlled trials in I type design.I.e. prospective trial Journal of Sex Research.

Treatment group: doctor trained in Western medicine basis Treatment of Hypertension+treatment hepatic and renal YIN deficiency of the present invention is held concurrently the hypertensive Chinese medicine foot bath of the turbid upper illiteracy type of expectorant.

Matched group: doctor trained in Western medicine basis Treatment of Hypertension ten warm water foot care.

2.2. the estimation of sample size: adopt prospective trial Journal of Sex Research, in conjunction with research funding and human resources, plan is received altogether

Lump case load 150 example.

2.3. randomized grouping: choose hyperpietic 150 example by inclusive criteria and exclusion standard, uses table of random number to produce random digit, by simple randomizing method, patient is divided into treatment group and matched group.

3 therapeutic schemes

3.1 doctor trained in Western medicine basis Treatment of Hypertensions: treatment group, matched group are all selected.Basis depressor only selects calcium-channel antagonists and diuretic, and does not select Β receptor blocking agent, ACEI and ARB class, to reduce the impact of basic medication on RAAS system.

3.2 GP TH

(1) treatment group: 1. medicine: Fructus Lycii 15g, Herba Ecliptae 15g, Fructus Mori 15g, Semen Sesami Nigrum 10g, Radix Rehmanniae Preparata 15g, Concha Haliotidis 15g, Fructus Tribuli 10g, Herba Apocyni veneti 10g, Rhizoma Gastrodiae 10g, Ramulus Uncariae Cum Uncis 10g, Rhizoma Pinelliae 6g, Rhizoma Arisaematis 6g, Fructus Gleditsia 6g, Rhizoma Acori Graminei 6g, Herba Pogostemonis 10g, Herba Eupatorii 10g, Periostracum Cicadae 9g, Folium Mori 9g, Flos Chrysanthemi 9g, Caulis Polygoni Multiflori 15g, Cortex Albiziae 10g, Semen Ziziphi Spinosae 10g, Fructus Evodiae 6g, Radix Glycyrrhizae 6g, be ground into coarse powder, add boiling water 1500ml.

2. equipment: special foot bathing basin, water thermometer, stethoscope, Omron electric sphygmomanometer.

3. Therapeutic Method: the primary hypertension patient 75 examples being met to inclusive criteria doctor trained in Western medicine basis Treatment of Hypertension add simultaneously of the present invention turbid for hepatic and renal YIN deficiency expectorant on the hypertensive Traditional Chinese medicine foot-bath of illiteracy type, day once, each potion, give 1500ml boiling water to brew, break up, stir latter standing five minutes, add appropriate cold water, be 42 ~ 45 degree to water temperature, patient starts foot care.The arrangement of time of foot bath is when 3-4 every afternoon, and foot bath time remaining 20min, lies up before and after foot bath, unified with Omron electric sphygmomanometer measurement right upper arm blood pressure.Respectively at before foot bath, foot bath terminates each Measure blood pressure of rear 40min once, adverse reactions of patients during observing foot bath at any time, and carries out a record, the course for the treatment of is 1 week.

(2) matched group: 75 examples meet the patient of inclusive criteria in doctor trained in Western medicine Primary Care, then add and use warm water foot bath, once a day.Warm water foot bath water temperature, the water yield, operational approach are all the same.

3.3 courses for the treatment of: two groups of courses for the treatment of are 1 week.

4 observation index and efficacy evaluation

4.1. observation item:

1. tcm symptom is observed: record treatment is front and treat patient's symptom after a week, sign change.

2. clinical indices: observe every day treatment before and after blood pressure, changes in heart rate, record and calculate pulse pressure (PP), put down

Equal arterial pressure (MAP).

3. untoward reaction is observed.

4.2 safety indexes:

Routine blood test, routine urinalysis, stool routine examination+occult blood; Liver function, kidney function test.If there is untoward reaction, should observe in detail and record its clinical manifestation, the order of severity, Testing index is abnormal, and sweep-out method and time etc., for objective evaluation safety provides foundation.

4.3 curative effect determinate standard

4.3.1 efficacy evaluation method: blood pressure curative effect determinate standard, according to " new Chinese medicine Hypertension guideline of clinical investigations " criterion of therapeutical effect of Ministry of Public Health promulgation in 1993.

1. blood pressure lowering standard:

Effective: diastolic pressure more than decline 10mmHg, and reach normal range.Although diastolic pressure does not drop to normally, oneself

Decline 20mmHg or more; Wherein one must be possessed.

Effective: diastolic pressure is declined by less than 10mmHg, but be down to normal range.Diastolic pressure comparatively treats front decline 10-19

MmHg, but do not reach normal range.Systolic pressure comparatively treats front more than decline 30mmHg, must possess wherein one.

Invalid: not reach above standard.

2. symptom criterion of therapeutical effect: with reference to " new Chinese medicine guideline of clinical investigations " with the ratio of the integral difference before and after treating compared with the integration before treatment to evaluate curative effect:

Total mark x100% before therapeutic effect of syndrome rate=(before treatment the rear total mark of total mark-treatment)/treatment

Effective: clinical symptoms, sign are obviously improved, syndrome integral reduces 70%.

Effective: clinical symptoms, sign are clearly better, syndrome integral reduces 30%.

Invalid: clinical symptoms, sign are not improved, even increase the weight of, syndrome integral reduces less than 30%.

4.3.2. safety assessment standard

1 grade: safety, without any untoward reaction, safety indexes checks without exception;

2 grades: safer, have slight untoward reaction, not needing to do any process can continue administration, and safety indexes is examined

Look into without exception;

3 grades: have safety issue, have moderate untoward reaction, or safety indexes inspection there is mile abnormality,

Administration can be continued after processing;

4 grades: because of serious adverse reaction termination test, or safety indexes inspection is obviously abnormal.

5 statistical method

Data, after logical verify, are inputted computer by various data, adopt the process of SPSS13.O statistical software, meter

Amount data first carries out normality distribution inspection and homogeneity test of variance, if in normal distribution, variance is neat, then row t checks, otherwise row t, inspection, enumeration data X 2 test.

6. result

6.1 all cases 150 examples, are and meet hypertension liver-Yang sthenia type diagnosis patient, wherein treatment group 75 example,

Matched group 75 example.

(1) age, body weight, mean blood pressure Average value compare is respectively organized before treatment: the equal not statistically significant of difference (P>O.05), in table 1.

Before and after (2) two groups of patient treatments, pressure value compares.

Treat between first two groups and compare between systolic pressure, diastolic pressure group, no significant difference (P>0.05); The systolic pressure that treatment is latter two groups, diastolic pressure obviously improve (reduction) before all comparatively treating, and treatment group is improved situation and is obviously better than matched group, and difference has statistical significance (P<0.01), in table 2.

The comparison of pulse pressure difference, mean arterial pressure before and after (3) two groups of patient treatments

Treat between first two groups and compare between pulse pressure difference, mean arterial pressure group, no significant difference (P>0.05); The pulse pressure difference that treatment is latter two groups, mean arterial pressure obviously improve (reduction) before all comparatively treating, and treatment group is improved situation and is obviously better than matched group, and difference has statistical significance (P<0.05), in table 3.

(4) clinical symptoms is improved and observation of curative effect

Before and after treatment, two groups of traditional Chinese medical science main clinic symptoms score and total score improve situation, in table 4.Treat the headache of first two groups, dizzy, insomnia, tinnitus and irritable score compare, the equal not statistically significant of difference (P>0.05), headache after treatment, dizzy, insomnia, tinnitus, irritable score all comparatively obviously reduction before treatment, treatment group reduces situation and is obviously better than matched group, difference has statistical significance (P<0.05), and comparatively matched group improvement is obvious to point out above-mentioned symptom treatment group after treatment.

Treat symptom score total score comparing difference not statistically significant (P>0.05) of first two groups, after treatment, the symptom score total score of two groups is obviously improved (reduction) before all comparatively treating, improvement (reduction) situation for the treatment of group is obviously better than matched group, difference has statistical significance (P<0.05), in table 4.

(5) symptom scores general curative effect, in table 5.

According to the standard of curative effect evaluation, can show that the total effective rate for the treatment of group is 98.67%, matched group total effective rate 76.O%; Both are more known, and treatment group curative effect is better than matched group, and difference has statistical significance (P<0.05), in table 5.

(6) untoward reaction

Treatment group and matched group all do not find untoward reaction over the course for the treatment of.

Claims (3)

1. treat the hepatic and renal YIN deficiency to hold concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, be made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Lycii 11-19 part, Herba Ecliptae 11-19 part, Fructus Mori 11-19 part, Semen Sesami Nigrum 6-14 part, Radix Rehmanniae Preparata 11-19 part, Concha Haliotidis 11-19 part, Fructus Tribuli 6-14 part, Herba Apocyni veneti 6-14 part, Rhizoma Gastrodiae 6-14 part, Ramulus Uncariae Cum Uncis 6-14 part, Rhizoma Pinelliae 4-8 part, Rhizoma Arisaematis 4-8 part, Fructus Gleditsia 4-8 part, Rhizoma Acori Graminei 4-8 part, Herba Pogostemonis 6-14 part, Herba Eupatorii 6-14 part, Radix Paeoniae Rubra 6-14 part, Radix Salviae Miltiorrhizae 6-14 part, Rhizoma Chuanxiong 6-14 part, Semen Persicae 6-14 part, Flos Carthami 6-14 part, Periostracum Cicadae 5-13 part, Folium Mori 5-13 part, Flos Chrysanthemi 5-13 part, Caulis Polygoni Multiflori 11-19 part, Cortex Albiziae 6-14 part, Semen Ziziphi Spinosae 6-14 part, Fructus Evodiae 4-8 part, Radix Glycyrrhizae 4-8 part.

2. the treatment hepatic and renal YIN deficiency according to claim 1 is held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, it is characterized in that, is made up of the raw material of Chinese medicine medicine of following weight portion:

Fructus Lycii 13-17 part, Herba Ecliptae 13-17 part, Fructus Mori 13-17 part, Semen Sesami Nigrum 8-12 part, Radix Rehmanniae Preparata 13-17 part, Concha Haliotidis 13-17 part, Fructus Tribuli 8-12 part, Herba Apocyni veneti 8-12 part, Rhizoma Gastrodiae 8-12 part, Ramulus Uncariae Cum Uncis 8-12 part, Rhizoma Pinelliae 5-7 part, Rhizoma Arisaematis 5-7 part, Fructus Gleditsia 5-7 part, Rhizoma Acori Graminei 5-7 part, Herba Pogostemonis 8-12 part, Herba Eupatorii 8-12 part, Radix Paeoniae Rubra 8-12 part, Radix Salviae Miltiorrhizae 8-12 part, Rhizoma Chuanxiong 8-12 part, Semen Persicae 8-12 part, Flos Carthami 8-12 part, Periostracum Cicadae 7-11 part, Folium Mori 7-11 part, Flos Chrysanthemi 7-11 part, Caulis Polygoni Multiflori 13-17 part, Cortex Albiziae 8-12 part, Semen Ziziphi Spinosae 8-12 part, Fructus Evodiae 5-7 part, Radix Glycyrrhizae 5-7 part.

3. the treatment hepatic and renal YIN deficiency according to claim 2 is held concurrently the hypertensive Chinese medicine of the turbid upper illiteracy type of expectorant, and it is characterized in that, the described raw material of Chinese medicine medicine by following weight portion is made:

Fructus Lycii 15 parts, Herba Ecliptae 15 parts, Fructus Mori 15 parts, Semen Sesami Nigrum 10 parts, Radix Rehmanniae Preparata 15 parts, Concha Haliotidis 15 parts, Fructus Tribuli 10 parts, Herba Apocyni veneti 10 parts, 10 parts, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis 10 parts, the Rhizoma Pinelliae 6 parts, Rhizoma Arisaematis 6 parts, 6 parts, Fructus Gleditsia, Rhizoma Acori Graminei 6 parts, Herba Pogostemonis 10 parts, Herba Eupatorii 10 parts, Radix Paeoniae Rubra 10 parts, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Chuanxiong 10 parts, 10 parts, Semen Persicae, 10 parts, Flos Carthami, Periostracum Cicadae 9 parts, 9 parts, Folium Mori, Flos Chrysanthemi 9 parts, Caulis Polygoni Multiflori 15 parts, Cortex Albiziae 10 parts, Semen Ziziphi Spinosae 10 parts, Fructus Evodiae 6 parts, 6 parts, Radix Glycyrrhizae.