CN104906131B - A kind of preparation method preventing and treating lamb stomatitis plaster - Google Patents
A kind of preparation method preventing and treating lamb stomatitis plaster Download PDFInfo
- Publication number
- CN104906131B CN104906131B CN201510320474.9A CN201510320474A CN104906131B CN 104906131 B CN104906131 B CN 104906131B CN 201510320474 A CN201510320474 A CN 201510320474A CN 104906131 B CN104906131 B CN 104906131B
- Authority
- CN
- China
- Prior art keywords
- iodine
- tincture
- lamb
- menthol
- stomatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
A kind of preparation method preventing and treating lamb stomatitis plaster, includes the following steps：1) 1~3g menthol is dissolved in 25~75ml tincture of iodine, obtains tincture of iodine menthol solution；2) glycerol and tincture of iodine menthol solution made of step (1) for measuring 25~75ml mix, and obtain mixed solution；3) it weighs 1~3g xanthan gum to be dissolved in 25~75ml water, sufficiently dissolves, obtain jelly；4) by step (2) obtain jelly made of mixed solution and (3) step be sufficiently mixed to get.The present invention mainly as lamb stomatitis external application prevention and treatment, can anti-inflammatory, analgesic, it is antipruritic, promote blood circulation, mitigate edema, to bacterium, virus have killing effect.
Description
Technical field
The invention belongs to veterinary drug technical fields, and in particular to a kind of preparation method for preventing and treating lamb stomatitis plaster.
Background technique
Sheep mouth inflammation is the inflammation of surface of the oral mucosa and deep tissues.In pathologic process, mucous membrane of mouth and gingival inflammation,
Sick sheep feeding and bradymassesis, watery saliva flowing from the mouth, sensitivity to pain can be made to increase.Clinical common simple local inflammation and secondary
General reaction.New-bom lamb relies primarily on lactation and obtains nutrition within one week, after a week, as lamb gradually grows up, start mould
Imitative ewe feeding feed, bite object of various shapes.But it since the oral area of new-bom lamb is mucocutaneous especially delicate, is easy to
It is injured damaged, stomatitis occurs after infected.Once infection stomatitis, sick sheep shows poor appetite, and salivation in mouth, chewing is slow, by
It is reluctant to search for food in pain, it sometimes can also secondary halitosis.If sick sheep cannot be cured timely, appetite will occur for sick sheep
Decline even completely without, ruminate that reduction, that coat is unglazed is mixed and disorderly, gradually thin, finally cause disease lamb hungry to death.
At present in sheep raising production, prevention and treatment lamb stomatitis mainly uses some disinfectants, as slight stomatitis can be with 0.1%
Rivanol or 0.1% liquor potassic permanganate wash oral cavity, can also be rinsed with 2% alum；When rotten to the corn and exudation occurs, use
2% alum rinses；When mucous membrane of mouth has ulcer, jodine glycerin, 5% tincture of iodine, aldrich mixture, sulfanilamide (SN) ointment, tetracycline can be used
Ointment etc. embrocates affected part；If secondary bacterial infection can carry out intramuscular injection with penicillin, streptomysin etc. when sick sheep body temperature increases,
2 times a day, it is used in conjunction 3~5 days, can also take or inject sulfa drugs.
It is found during preventing and treating lamb stomatitis using above method, above-described all kinds of common disinfectants some are not
Be easy disease sites adhere to, protective covering can not be formed in patient part, thus cannot disease sites stop compared with
The long time plays drug effect, and curative effect is slower；Other have lamb certain if sulfamido, Tetracyclines ointment are due to its bitter
Irritation, and be commonly used and be easy to produce drug resistance.And the use of antibiotics, and easily lead to resist (resistance to) pharmacological property
The problems such as residual exceeded with cultivation class medicine, or even the mammogenesis of ewe lamb is influenced, it does not meet animal welfare, develop non-nuisance
Industry, the demand for producing green aquatic product.
Summary of the invention
For technological deficiency present in prior art prevention and treatment lamb stomatitis, the purpose of the present invention is to provide a kind of costs
The preparation method of the ointment of cheap, convenient to use, effective prevention and treatment lamb stomatitis, ointment practical application prepared by the present invention
Effect is good, it is at low cost, be easily worked production, there are preferable market prospects.
The present invention is realized especially by following technical scheme：
A kind of preparation method preventing and treating lamb stomatitis plaster, includes the following steps：
1) 1~3g menthol is dissolved in 25~75ml tincture of iodine, obtains tincture of iodine menthol solution；
2) glycerol and tincture of iodine menthol solution made of step (1) for measuring 25~75ml mix, and obtain mixed solution；
3) it weighs 1~3g xanthan gum to be dissolved in 25~75ml water, sufficiently dissolves, obtain jelly；
4) by step (2) obtain jelly made of mixed solution and (3) step be sufficiently mixed to get.
The mass concentration of iodine is 20g/L, i.e., 2% tincture of iodine in the tincture of iodine.
The ointment is mainly used for after treatment is born to the lamb stomatitis in 60 ages in days.
Preferably, a kind of preparation method preventing and treating lamb stomatitis plaster, includes the following steps：
1) 2g menthol is dissolved in the tincture of iodine that 50ml concentration is 2%, obtains tincture of iodine menthol solution；
2) glycerol and tincture of iodine menthol solution made of step (1) for measuring 50ml mix, and obtain mixed solution；
3) it weighs 2g xanthan gum to be dissolved in 50ml water, sufficiently dissolves, obtain jelly；
4) by step (2) obtain jelly made of mixed solution and (3) step be sufficiently mixed to get.
The mass concentration of iodine is 20g/L, i.e., 2% tincture of iodine in the tincture of iodine.
Ointment preparation prepared by the method for the present invention is also within the scope of protection of the invention.The ointment preparation is main
For preventing and treating after birth to the lamb stomatitis in 60 ages in days.
The tincture of iodine in ointment of the present invention, the tincture of iodine are commonly called as the tincture of iodine, medically the commonly referred to as tincture of iodine, are for skin infection and disinfection
Disinfection preservative, be alcohol is dissolved in iodine, potassium iodide and made of 2% solution.Its mechanism of action is to make bacterium protein
Denaturation, it is dead, there is killing effect to bacterium, virus.The function of the tincture of iodine be mainly used as skin and injection before, operative site disappears
Poison.
Glycerol, glycerine is colourless sweet clear and bright thick liquid, odorless, has warm sweet taste, is commonly called as glycerol, can inhale from air
Moisture is received, is the constituent of a variety of skincare products.
Menthol, a kind of chemical agent, menthol in the leaf and stem of peppermint by being extracted, white crystal, molecular formula
C10H20O is the main component in peppermint and lavender essential oil.In the world, India is main natural peppermint producing country.It is thin
Lotus brain and Racementhol can be employed as toothpaste；Perfume；The odorant of beverage and candy etc..It is used as excitants in medicine, makees
For skin or mucous membrane, there is refrigerant itching-relieving action；It is for oral administration to can be used as carminative, for headache and nose；Pharynx；Laryngitis etc..Its ester
For fragrance and drug.Peppermint brain-capacity selectively stimulates the frigidoreceptor of human skin or mucous membrane, generate sense of cold reflection and
Creeping chill causes skin and mucosa vessel retraction (actually skin keeps normal)；In addition the blood vessel of deep tissue can also be caused to receive
Contracting, and generate therapeutic effect.External application can be relieved pain with anti-inflammatory, antipruritic, promoted blood circulation, mitigated edema etc..
Xanthan gum, also known as yellow glue, xanthan gum, Xanthan Gum are a kind of monospores generated by pseudo xanthomonas fermentation
Polysaccharide, by cabbage black rot xanthomonas campestris using carbohydrate as primary raw material, through aerobic fermentation biotechnology,
1,6- glycosidic bond is cut off, after opening branch, in a kind of acidic extracellular heteroglycan of acidity for being bonded to straight chain composition by Isosorbide-5-Nitrae-.Xanthan gum is
Send out liquor-saturated through Xanthomonas campestris by carbohydrate, the more pools of extracellular microorganism of generation.Due to its macromolecular special construction and colloid property,
And there are multiple functions, it can be used as emulsifier, stabilizer, gelling thickener, size, film forming agent etc..Xanthan gum is known as
" industrial monosodium glutamate " is the microbial polysaccharide that production scale is maximum in the world at present and purposes is extremely wide.It, can in pharmaceutical products
As setting agent, suspending agent, moisturizer, there is thickening, attachment, lubricating action, improve the adhesion property of paste, good dispersion.
Beneficial effects of the present invention are：Ointment of the present invention based on clearing heat and detoxicating, can anti-inflammatory, analgesic, it is antipruritic, promote blood
Circulation mitigates edema, has killing effect to bacterium, virus, for having after treatment birth to the lamb stomatitis in 60 ages in days
Significant curative effect.Paste of the present invention is easy to use simultaneously, has long-acting, convenient and simple, preparation process is simple, easy to spread
It uses.
Specific embodiment
The present invention will be further explained with reference to the examples below, as described below, is only to preferable implementation of the invention
Example, not limits the present invention, any person skilled in the art is possibly also with the disclosure above
Technology contents be changed to the equivalent embodiment changed on an equal basis.Without departing from the concept of the present invention, according to the present invention
Technical spirit any simple modification or equivalent variations that following embodiment is made, fall within the scope of protection of the present invention.
Embodiment 1
A kind of plaster for preventing and treating lamb stomatitis, consists of the following compositions：Tincture of iodine 50ml, glycerol 50ml, menthol 2g,
Xanthan gum 2g, pure water 50ml.
It is prepared by the following method：
1) 2g menthol is dissolved in the tincture of iodine that 50ml concentration is 2%, obtains tincture of iodine menthol solution；
2) glycerol and tincture of iodine menthol solution made of step (1) for measuring 50ml mix, and obtain mixed solution；
3) it weighs 2g xanthan gum to be dissolved in 50ml water, sufficiently dissolves, obtain jelly；
4) by step (2) obtain jelly made of mixed solution and (3) step be sufficiently mixed to get.
Embodiment 2
A kind of plaster for preventing and treating lamb stomatitis, consists of the following compositions：Tincture of iodine 25ml, glycerol 75ml, menthol 1g,
Xanthan gum 3g, pure water 25ml.
It is prepared by the following method：
1) 1g menthol is dissolved in the tincture of iodine that 25ml concentration is 2%, obtains tincture of iodine menthol solution；
2) glycerol and tincture of iodine menthol solution made of step (1) for measuring 75ml mix, and obtain mixed solution；
3) it weighs 3g xanthan gum to be dissolved in 25ml water, sufficiently dissolves, obtain jelly；
4) by step (2) obtain jelly made of mixed solution and (3) step be sufficiently mixed to get.
Embodiment 3
A kind of plaster for preventing and treating lamb stomatitis, consists of the following compositions：Tincture of iodine 75ml, glycerol 25ml, menthol 3g,
Xanthan gum 1g, pure water 75ml.
It is prepared by the following method：
1) 3g menthol is dissolved in the tincture of iodine that 75ml concentration is 2%, obtains tincture of iodine menthol solution；
2) glycerol and tincture of iodine menthol solution made of step (1) for measuring 25ml mix, and obtain mixed solution；
3) it weighs 1g xanthan gum to be dissolved in 75ml water, sufficiently dissolves, obtain jelly；
4) by step (2) obtain jelly made of mixed solution and (3) step be sufficiently mixed to get.
It is described further below with reference to therapeutic effect of the specific embodiment to ointment of the present invention.
The experiment of 4 therapeutic effect of embodiment
To the lamb in 60 ages in days after Qingdao of Shandong province Laoshan District milch goat farm chooses birth, therefrom select
Lamb 200 with stomatitis after making a definite diagnosis are used as treatment object, and select at random 200 lambs with stomatitis are divided into 4
Group (example 1 group, 2 groups of embodiment, 3 groups of embodiment and control group), every group 50, wherein Examples 1 to 3 group uses this respectively
1~3 gained plaster of inventive embodiments is treated, and in site of disease application during night, daily dressing is primary；Control group is using west
Medicine treatment, 25 tablets of metronidazoles of every net weight 0.2g are ground into powder, is mixed into 30ml warm water and is stirred, be eventually adding
70ml glycerol is hybridly prepared into the metronidazole glycerine mixture that concentration is 0.5%, first rinses sick sheep mouth with 0.2% potassium permanganate of concentration
After chamber, metronidazole glycerine mixture is embrocated in its affected part, daily each 1 time of morning and evening.Observe and record cure rate and the healing of each group sheep
Time, the results are shown in Table 1.
Curative effect determinate standard：
Recovery from illness：Suffer from sheep after treatment in 1 week, Oral symptoms disappear, and can normally feed, temperature recovery is normal.
Effectively：The Oral symptoms for suffering from sheep disappear substantially, and food-intake increases compared with before treatment, and temperature recovery is normal.
In vain：Suffer from sheep after treatment in 1 week, there are still and body temperature is higher, and food-intake is without increase for Oral symptoms.
1 therapeutic effect of table statistics
| Grouping | Embodiment 1 | Embodiment 2 | Embodiment 3 | Control group |
| Recovery from illness | 49 | 45 | 46 | 30 |
| Effectively | 1 | 4 | 4 | 11 |
| In vain | 0 | 1 | 0 | 9 |
| Recovery from illness number of days | 3 | 3 | 3 | 7 |
It was found from the data of table 1：Plaster of the invention is substantially better than western medicine group to sheep mouth inflammation therapeutic effect, controls simultaneously
It treats experiment and is significantly shorter than control group, illustrate that plaster of the present invention has positive effect in the long-acting of drug and on absorbing.
The experiment of 5 control efficiency of embodiment
In Qingdao of Shandong province, Laoshan District milch goat farm randomly selects just postnatal healthy lamb 200, will be with
200 lambs that machine is selected are divided into 4 groups (example 1 group, 2 groups of embodiment, 3 groups of embodiment and control groups), and every group 50, wherein
Examples 1 to 3 group is prevented and treated using 1~3 gained plaster of the embodiment of the present invention respectively, the application one in sheep lip of daily night
It is secondary；Control group do not use any drug, after being used in conjunction 10 days, take the pathological material of disease suspension of goat, to embodiment group 1, embodiment group 2,
The sheep of embodiment group 3 and control group mucous membrane scratch inoculation in sheep lip, observes and records the disease incidence of each group sheep, as a result such as 2 institute of table
Show.
2 preventive effect statistical data of table
| Grouping | Embodiment 1 | Embodiment 2 | Embodiment 3 | Control group |
| Sum | 50 | 50 | 50 | 50 |
| Infect number | 1 | 2 | 3 | 48 |
| Disease incidence | 2% | 4% | 6% | 96% |
| Protective rate | 98% | 96% | 94% | 4% |
It was found from the data of table 2：Chinese medicine composition of the invention has apparent preventive effect to sheep mouth inflammation.
Claims (6)
1. a kind of preparation method for preventing and treating lamb stomatitis plaster, it is characterised in that include the following steps：
1）1 ~ 3g menthol is dissolved in 25 ~ 75ml tincture of iodine, tincture of iodine menthol solution is obtained；
2）Measure the glycerol and step of 25 ~ 75ml（1）Manufactured tincture of iodine menthol solution mixes, and obtains mixed solution；
3）It weighs 1 ~ 3g xanthan gum to be dissolved in 25 ~ 75ml water, sufficiently dissolves, obtain jelly；
4）By step（2）Obtain mixed solution and（3）Walk made of jelly be sufficiently mixed to get.
2. it is according to claim 1 it is a kind of prevent and treat lamb stomatitis plaster preparation method, it is characterised in that including with
Lower step：
1）2g menthol is dissolved in the tincture of iodine that 50ml concentration is 2%, obtains tincture of iodine menthol solution；
2）Measure the glycerol and step of 50ml（1）Manufactured tincture of iodine menthol solution mixes, and obtains mixed solution；
3）It weighs 2g xanthan gum to be dissolved in 50ml water, sufficiently dissolves, obtain jelly；
4）By step（2）Obtain mixed solution and（3）Walk made of jelly be sufficiently mixed to get.
3. preparation method according to claim 1 or 2, it is characterised in that：The mass concentration of iodine is in the tincture of iodine
20g/L。
4. the obtained plaster of preparation method according to claim 1 or 2.
5. plaster according to claim 4 is in preparation for preventing and treating the application in lamb stomatitis drug.
6. application according to claim 5, it is characterised in that：The lamb is after being born to the lamb in 60 ages in days.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510320474.9A CN104906131B (en) | 2015-06-11 | 2015-06-11 | A kind of preparation method preventing and treating lamb stomatitis plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510320474.9A CN104906131B (en) | 2015-06-11 | 2015-06-11 | A kind of preparation method preventing and treating lamb stomatitis plaster |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104906131A CN104906131A (en) | 2015-09-16 |
| CN104906131B true CN104906131B (en) | 2018-11-16 |
Family
ID=54075851
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510320474.9A Expired - Fee Related CN104906131B (en) | 2015-06-11 | 2015-06-11 | A kind of preparation method preventing and treating lamb stomatitis plaster |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104906131B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793838A (en) * | 2019-02-22 | 2019-05-24 | 青岛农业大学 | A kind of plaster and preparation method thereof for preventing and treating chiru sheep mouth inflammation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536680A (en) * | 2013-09-27 | 2014-01-29 | 李文军 | Preparation for treating periodontosis |
-
2015
- 2015-06-11 CN CN201510320474.9A patent/CN104906131B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536680A (en) * | 2013-09-27 | 2014-01-29 | 李文军 | Preparation for treating periodontosis |
Non-Patent Citations (3)
| Title |
|---|
| 复方薄荷脑碘滴鼻液的制备及质量控制;薛艳丽;《中国医院药学杂志》;20071231;第27卷(第12期);第1748页 * |
| 羊口炎症状及防治;张守印;《吉林农村报》;20140411;第1页 * |
| 羊口炎的预防与治疗;肖晓薇;《当代畜禽养殖业》;20130228;第6页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104906131A (en) | 2015-09-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US8003782B1 (en) | Pharmaceutical composition of complex carbohydrates and essential oils and methods of using the same | |
| CN110151594A (en) | A kind of oral cavity composition and its application containing Ectoin and hyaluronic acid | |
| US20160000845A1 (en) | Extract of trigonella foenum-graecum | |
| CN102579702A (en) | Medicine for treating dental ulcer and preparation method thereof | |
| CN106794210A (en) | Comprising mangosteen extract or α, γ mangostin as the periodontosis prevention of active ingredient or improvement composition | |
| CN1927160A (en) | Gargle and its preparing process | |
| CN105213298A (en) | A kind of oral care gels and preparation method thereof | |
| CN101444555B (en) | Purely Chinese traditional medical film for curing oral ulcer and method for preparing same | |
| CN105125445B (en) | A kind of dentifrice composition | |
| CN108815232A (en) | A kind of draft antimicrobial fluid | |
| CN109481527B (en) | Traditional Chinese medicine composition for preventing or treating oral diseases and application thereof | |
| CN104906132B (en) | A kind of plaster for preventing and treating lamb stomatitis | |
| CN104906131B (en) | A kind of preparation method preventing and treating lamb stomatitis plaster | |
| CN111905058A (en) | Pharmaceutical composition for skin mucosa nursing and wound repair and preparation method thereof | |
| CN108938703A (en) | The gynecological gel of quick antibacterial | |
| CN113318057B (en) | Old people nursing toothpaste and preparation method and application thereof | |
| CN108578342A (en) | A kind of children's toothpaste | |
| CN107596355A (en) | A kind of Medical pain easing, the exterior-applied gel subsided a swelling, brought down a fever and preparation method thereof | |
| RU2548505C1 (en) | Method of treating chronic apical periodontitis | |
| CN110787288A (en) | Medical collagen oral ulcer protective gel and preparation method thereof | |
| CN110051723A (en) | A kind of fructus hippophae mouthspray and preparation method thereof | |
| CN104784311B (en) | Composition of medicine for preventing and treating animal aphtha hoof Huang and preparation method thereof | |
| KR20200077090A (en) | Composition for prevention or treatment of dental disease comprising an extract of cinnamon | |
| RU2751809C1 (en) | Method for treatment of periodontitis | |
| CN109646591B (en) | Composition for oral cavity and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181116 Termination date: 20200611 |