CN104888149B - The drug and its preparation process for treating cervical carcinoma - Google Patents
The drug and its preparation process for treating cervical carcinoma Download PDFInfo
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- CN104888149B CN104888149B CN201510375843.4A CN201510375843A CN104888149B CN 104888149 B CN104888149 B CN 104888149B CN 201510375843 A CN201510375843 A CN 201510375843A CN 104888149 B CN104888149 B CN 104888149B
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Abstract
The present invention relates to a kind of drugs for treating cervical carcinoma, it is to be prepared by ratio of weight and the number of copies by following raw material radix paeoniae rubras, Radix Curcumae, cortex dictamni, Radix Angelicae Sinensis, nidus vespae, Radix Salviae Miltiorrhizae, black nightshade, radices trichosanthis, Sculellaria barbata, curcuma zedoary, Asian puccoon, rhizoma arisaematis, peach kernel, Fructus Aurantii and subprostrate sophora, the present invention makes tumor regression or disappearance, it relieves pain, increase appetite, body's immunity is improved, patient survival is extended；Especially patient's tool that operation and chemicotherapy can not be carried out is had a better effect.
Description
Technical field
The present invention relates to a kind of drug more particularly to a kind of drug for treating cervical carcinoma and its preparation process, ProductNames
Referred to as tumor capsule for eliminating.
Background technique
Chinese medicine is used to treat the drug of above-mentioned cervical carcinoma in the prior art, and complicated component, manufacture craft is cumbersome, and treats
Effect is slow；And doctor trained in Western medicine is in the treatment, mostly uses operative treatment or chemicotherapy, however most of cervical cancer patient is being made a definite diagnosis
When, majority loses operative chance, and the patient that can partially carry out operation and chemicotherapy faces the problems such as medical expense is high again, and
And it is postoperative frequently result in complication, chemicotherapy toxicity is big, brings great pain to patient.
Summary of the invention
The present invention is directed to above-mentioned problems of the prior art, theoretical according to modern medicine and traditional Chinese medicine and pharmacy, in conjunction with more
Year clinical practice has developed a kind of drug for treating cervical carcinoma, and solving existing stage middle-advanced cervical carcinoma cannot perform the operation and chemicotherapy poison
The problem of being easy to cause complication greatly, the medicine good effect, the therapeutic agent that stage middle-advanced cervical carcinoma patient can be made to be easily accepted by, without any
Toxic side effect, it is at low cost, securely and reliably.
It is a further object to provide a kind of preparation processes of the drug of above-mentioned treatment cervical carcinoma.
The weight ratio range of each raw material of the present invention is to carry out largely groping to obtain with Test Summary by inventor,
The weight ratio of each raw material all has preferable effect in following weight range.The present invention is combined using following raw materials, by this
The effect of a little material combinations make each raw material generates synergistic effect, to reach clearing heat and detoxicating, stagnation resolvation disappears the effect of tying.
Technical scheme is as follows:
It is prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae:
Black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: subprostrate sophora=10-30:5-25:10-30:5-25:5-
15:10-25:10-30:5-25:20-40:2-14:5-25:3-12:5-15:2-14:5-25.
It is prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae:
Black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: subprostrate sophora=20:15:20:15:10:15:20:15:
30:8:15:7:10:8:15.
Preparation process of the invention includes the following steps:
Cleaning: radix paeoniae rubra, Radix Curcumae, cortex dictamni, Radix Angelicae Sinensis, nidus vespae, Radix Salviae Miltiorrhizae, black nightshade, radices trichosanthis, Sculellaria barbata, curcuma zedoary, purple are taken
Grass, rhizoma arisaematis, peach kernel, Fructus Aurantii and 15 taste medicinal material of subprostrate sophora are eluted with water；
Processing methods: above-mentioned 15 taste processing of crude drugs is cut into slices；
Decoct: 15 taste medicinal materials after taking above-mentioned processing to clean by above-mentioned weight fraction ratio add water to cook three times, add for the first time
The weight of water is 6-10 times of medicinal material, impregnates 0.5-1.5 hours, decocts 0.5-1.5 hours, for the second time, respectively adds water for the third time
Weight is 3-8 times of medicinal material, is decocted 0.5-1.5 hours, collecting decoction, and filtration obtains filtrate；
Dries pulverizing: taking above-mentioned filtrate, heats and is concentrated under reduced pressure into paste, 60 DEG C of heat survey relative densities 1.35, and 60-90 DEG C
Decompression drying crushes, and get dry extract powder, and encapsulated: 0.4g to obtain the final product.
Advantages of the present invention effect is as follows:
1, make tumor regression or disappearance, relieve pain, increase appetite, improve body's immunity, extend patient survival；
Especially patient's tool that operation and chemicotherapy can not be carried out is had a better effect.
2, good effect, treatment time is short, without any side effects, no taboo, securely and reliably, easy to use, convenient for holding
With.
3, process for machining and manufacturing is simple, and process is short, and raw material sources are easy to get, at low cost, small in size, is convenient for carrying, production fortune
Defeated storage has extensive market prospects without any risk.
Specific embodiment
Below by way of clinic, the beneficial effect of drug effect and toxicity test come that the present invention is further explained drug.
Clinical test curative effect of medication visual report of the present invention
202 hospital's oncology of liberation army
Chinese medicine tumor capsule for eliminating is compound preparation, by the pharmaceutical research and animal experimental observation of our hospital's many years, it was demonstrated that should
Medicine has significant killing and inhibiting effect to cervix cancer, and has received apparent curative effect in clinical application, clinical effectiveness report
It accuses as follows:
Clinical data
1, stage middle-advanced cervical carcinoma and the treatment appropriate time such as lost operation, chemotherapy, radiotherapy suffer from 67, average age
53.5 years old.Pathological diagnosis squamous carcinoma 65.Gland cancer 2.67 Patients with Cervical Cancer oral traditional Chinese medicine tumor capsule for eliminating four a time 1 day 3 times.1
A month is 1 course for the treatment of.Each case is not in 3 courses for the treatment of.And according to circumstances give supporting treatment.
2, efficacy determination, by efficacy assessment standard specified in " new Chinese medicine clinical guidance principle ".(1) complete incidence graph
(CR healing): all lesions visibles completely disappear in CT or B ultrasound follow-up, and at least maintain 4 weeks or more person；(2) (PR is alleviated in part
It is effective): the maximum gauge and its maximum perpendicular diameter product of CT or B ultrasound scanning tumor focus reduce 50% or more and maintain 4 weeks or more
Person；(3) improve (MR is effective): two diameter product of tumor focus increases < 25% or increases < 25% or new lesion occur.Overall response rate: CR
+ PR+MR(stablizes case and is not included in).It treats life cycle: being calculated since treatment to dead last follow up time.
3, result
67 Patients with Cervical Cancer 55 tumours different degrees of diminution and symptom after treating are obviously improved, and show as abdomen
Pain is alleviated or disappears, and appetite increases, and abdominal distension is alleviated.It is shown in Table 1.
4, it discusses
67 cervical cancer patient clinical therapeutic efficacies are treated with tumor capsule for eliminating herein to show: can obviously improve middle and advanced stage uterine neck
The clinical symptoms of cancer people extend life cycle, improve survival rate, and some patientss is made to obtain hand due to knurl is obviously reduced in lump
Art therapy apparatus meeting.67 stage middle-advanced cervical carcinoma treatment results show: up to 82.3%, tumor capsule for eliminating anti-cervical cancer acts on total effective rate
Curative for effect, it can select killing cervical cancer cell, not damage to normal cell.Clinic does not find that poison pays effect.It is worthy to be popularized.
Embodiment 1
It is prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae:
Black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: subprostrate sophora=20:15:20:15:10:15:20:15:
30:8:15:7:10:8:15.
Preparation process of the invention includes the following steps:
Cleaning: radix paeoniae rubra, Radix Curcumae, cortex dictamni, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, black nightshade, radices trichosanthis, Sculellaria barbata, curcuma zedoary, Asian puccoon, Tian Nan are taken
Star, peach kernel, Fructus Aurantii and 15 taste medicinal material of subprostrate sophora are eluted with water；
Processing methods: above-mentioned 15 taste medicine processing is cut into slices；
Decoct: 15 taste medicinal materials after taking above-mentioned processing edulcoration by above-mentioned weight fraction ratio add water to cook three times, add for the first time
The weight of water is 6-10 times of medicinal material, impregnates 0.5-1.5 hours, decocts 0.5-1.5 hours, for the second time, respectively adds water for the third time
Weight is 3-8 times of medicinal material, is decocted 0.5-1.5 hours, collecting decoction, and filtration obtains filtrate；
Dries pulverizing: taking above-mentioned filtrate, and heating is concentrated under reduced pressure into paste, and 60 DEG C of heat survey relative density about 1.35,60-90
DEG C decompression drying crushes, and get dry extract powder, and encapsulated: 0.4g to obtain the final product.
Embodiment 2
It is prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae:
Black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: subprostrate sophora=10:5:10:5:5:10:10:5:20:
2:5:3:5:2:5.
In the decoction step: 15 taste medicinal materials after taking above-mentioned processing edulcoration add water to cook three times, add water for the first time
Weight is 6 times of medicinal material, and immersion 0.5 hour decocts 0.5 hour, and respectively adding the weight of water for the second time, for the third time is 3 times of medicinal material,
It decocts 0.5 hour；Other steps are the same as embodiment 1.
Embodiment 3
It is prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae:
Black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: subprostrate sophora=30:25:30:25:15:25:30:25:
40:14:25:12:15:14:25.
In the decoction step, for the first time plus the weight of water is 10 times of medicinal material, impregnates 1.5 hours, it is small to decoct 1.5
When, respectively adding the weight of water for the second time, for the third time is 8 times of medicinal material, is decocted 1.5 hours；Other steps are the same as embodiment 1.
Embodiment 4
It is prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae:
Black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: subprostrate sophora=30:25:10:5:5:25:30:5:20:
14:5:12:5:2:5.
In the decoction step, for the first time plus the weight of water is 10 times of medicinal material, impregnates 0.5 hour, it is small to decoct 0.5
When, respectively adding the weight of water for the second time, for the third time is 3 times of medicinal material, is decocted 0.5 hour；Other steps are the same as embodiment 1.
Embodiment 5
It is prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae:
Black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: subprostrate sophora=10:5:30:5:15:10:30:25:
40:2:25:12:15:2:25.
Claims (3)
1. a kind of drug for treating cervical carcinoma, it is characterised in that it is to be prepared by ratio of weight and the number of copies by following raw materials, radix paeoniae rubra: strongly fragrant
Gold: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae: black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: rhizoma arisaematis: peach kernel: Fructus Aurantii: mountain beans
Root=10-30:5-25:10-30:5-25:5-15:10-25:10-30:5-25:20-40:2-14:5-25:3-12:5-15:2-
14:5-25.
2. it is according to claim 1 treatment cervical carcinoma drug, it is characterised in that be by following raw materials by ratio of weight and the number of copies
It is prepared, radix paeoniae rubra: Radix Curcumae: cortex dictamni: Radix Angelicae Sinensis: nidus vespae: Radix Salviae Miltiorrhizae: black nightshade: radices trichosanthis: Sculellaria barbata: curcuma zedoary: Asian puccoon: day south
Star: peach kernel: Fructus Aurantii: subprostrate sophora=20:15:20:15:10:15:20:15:30:8:15:7:10:8:15.
3. preparing the preparation process of the drug for the treatment of cervical carcinoma described in claim 1, it is characterised in that include the following steps:
Cleaning: radix paeoniae rubra, Radix Curcumae, cortex dictamni, Radix Angelicae Sinensis, nidus vespae, Radix Salviae Miltiorrhizae, black nightshade, radices trichosanthis, Sculellaria barbata, curcuma zedoary, Asian puccoon, day are taken
Southern Star, peach kernel, Fructus Aurantii and 15 taste medicinal material of subprostrate sophora are eluted with water；
Processing methods: above-mentioned 15 taste processing of crude drugs is cut into slices；
Decoct: 15 taste medicinal materials after taking above-mentioned processing to clean by above-mentioned weight fraction ratio add water to cook three times, add water for the first time
Weight is 6-10 times of medicinal material, impregnates 0.5-1.5 hours, decocts 0.5-1.5 hours, respectively adds the weight of water for the second time, for the third time
It is 3-8 times of medicinal material, decocts 0.5-1.5 hours, collecting decoction, filtration obtains filtrate；
Dries pulverizing: taking above-mentioned filtrate, and heating is concentrated under reduced pressure into paste, and 60 DEG C of heat survey relative density 1.35,60-90 DEG C of decompression
Drying crushes, and get dry extract powder, encapsulated: in each capsule the weight of dried cream powder be 0.4g to get.
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| CN105287805A (en) * | 2015-12-04 | 2016-02-03 | 钱玲科 | Traditional Chinese medicine combination extract and application thereof in preparation of medicines for treating cervical carcinoma |
| CN107982490A (en) * | 2018-01-19 | 2018-05-04 | 张冬丽 | A kind of external used medicine applied to cervical carcinoma and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140023738A1 (en) * | 2010-07-01 | 2014-01-23 | Universidade Federal De Alagoas - Ufal | Pharmaceutical composition using stryphnodendron extracts for treating hpv infections |
| CN104248741A (en) * | 2013-06-26 | 2014-12-31 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Traditional Chinese medicinal composition for treating cancers, and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140023738A1 (en) * | 2010-07-01 | 2014-01-23 | Universidade Federal De Alagoas - Ufal | Pharmaceutical composition using stryphnodendron extracts for treating hpv infections |
| CN104248741A (en) * | 2013-06-26 | 2014-12-31 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Traditional Chinese medicinal composition for treating cancers, and preparation method thereof |
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