CN104887968A - Traditional Chinese medicine preparation for preventing contrast associated nephropathy as well as preparation method - Google Patents

Abstract

The invention provides a traditional Chinese medicine preparation for preventing contrast associated nephropathy as well as a preparation method. The traditional Chinese medicine preparation comprises raw materials as follows: sandalwood, cypress roots, herb of siebold buttercup, roots of Dysosma difformis, Terminthia peniculata, Semen Juglandis, Habenaria tenaculata Reichb, Parameria laevigata, Herminium monorhis(L.)R.Br., Chinese photinia leaves, Adiantum capillus junosis Rupr., wild soybean, Flueggea suffruticosa, freshwater sponge, all-grass of bulley herminium, Dendrobium densiflorum Lindl ex Wall, Herminium monorchis and Radix seu Spiranthis Lanceae. The traditional Chinese medicine preparation has the benefits of definite curative effect on prevention of contrast associated nephropathy as well as little toxic and side effects.

Description

A kind of Chinese medicine preparation and preparation method of preventing radiographic contrast nephropathy

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine preparation and preparation method of preventing radiographic contrast nephropathy.

Background technology

Along with extensively carrying out of modern shadowgraph technique, radiographic contrast nephropathy (contrast associated nephropathy, CAN) receives the concern of nephropathy worker day by day.CAN refers to the hurried decline of renal function caused by contrast agent.Conventional contrast agent is generally hypertonicity, and amount of iodine, up to 37%, is not absorbed by renal tubules by glomerular filtration with original shape in vivo, and during dehydration, this medicine concentration in kidney increases, and can cause renal damage and acute renal failure occur.Acute renal failure report caused by contrast agent increases increasingly, and even its incidence rate has exceeded caused by aminoglycoside antibiotics.Large quantity research report, CAN accompanies renal insufficiency to be 6% ~ 92%, does not accompany renal insufficiency to be 0 ~ 22%.A large amount of prospective control study is pointed out, after general injection contrast agent, namely serum creatinine value has diagnostic significance higher than 25% ~ 50% of basic value.

Person's serum creatinine raises usually in 24h to accept contrast agent, 96h peaking, within general 7 ~ 10 days, replys afterwards and reaches basic value.But also have report, renal function declined in Progressive symmetric erythrokeratodermia in 1 ~ 3 week, then reply and reach basic value.Can there is oliguria in early days in more than 60% CAN patient, have resistance, also have non-oliguria person to button loop diuretic.Most patients renal function can clear-cutting forestland, and 10% need dialysis treatment, and irreversible renal failure person is rare, needs long term maintenance to dialyse.

There is renal cells, cast and various fragment in uroscopy, non-specific in urinating as seen, uncorrelated with change in renal function.Urate crystal is common, and even visible Citric acid calcium crystallization, High-grade Proteinuria is uncommon.Have the Most patients of acute tubular necrosis, renal sodium excretion is often greater than 40mmol/L, and fractional excretion of sodium (FENa) is greater than 1%; But have 1/3 acute renal failure person renal sodium excretion lower than 20mmol/L, oliguria person's fractional excretion of sodium is less than 1%.

After contrast agent application, x-ray is taken the photograph the two kidney development of sheet and is continued to reach the characteristic performance that 24 ~ 48h is CAN.Older under observation finds, x-ray is taken the photograph sheet sensitivity and reached 83%, and specificity up to 93%, but also has false positive and false negative result.Therefore CAN still needs in addition clear and definite in conjunction with serum creatinine measured value in 24 ~ 48h.

The renal failure that CAN must cause with cholesterol micro-embolization (cholesterol microemboli) is differentiated mutually.Cholesterol emboli ties up to conduit in angiographic procedure and assigns caused by injured blood vessel.Can be there is the sings and symptoms (as lower limb or chronic foot pain, stomachache, back pain, numb limbs and tense tendons are even benumbed, skin of lower extremity is pale) of blood vessel embolism in acute person, diagnose more difficult after accepting contrast agent.Patient can occur that hypotension, oliguria are even cause death due to multi viscera infarction.Chronic type person is usually expressed as Progressive symmetric erythrokeratodermia renal insufficiency and reaches more than several weeks and develop into irreversibility renal failure.In skin, microembolism syndrome diagnosis basis occurs that livedo reticularis, amylase raise and peripheral blood eosinophilia, uropsammus examination is negative, and Renal biospy shows distinctive cholesterol emboli.

Conventional contrast agent is hypertonicity, and do not absorbed by renal tubules by glomerular filtration with original shape in vivo, during dehydration, this medicine concentration in kidney increases, and can cause renal damage and acute renal failure occur.It is below easily cause the risk factor of renal damage and possible risk factor: 1, risk factor; (1) original renal insufficiency.(2) with the diabetes of renal insufficiency: have diabetes medical history more than 10 years, more than 50 years old, there are cardiovascular complication and renal insufficiency person danger at the age greatly.(3) congestive heart failure: the congestive heart failure person that cardiac function is IV grade is obvious risk factor.Because contrast agent can make Renal vascular shrink, renal blood flow reduces, and adds the danger of patients with congestive heart failure generation ischemic renal failure.(4) nephrotic syndrome.(5) liver cirrhosis companion renal function injury.(6) hypovolemia or dehydration: find in the experimentation of Canis familiaris L., under dewatering state, contrast agent can cause blood vessel in kidney significantly to shrink.(7) multiple myeloma: intravenous contrast agent can cause acute renal failure, was once once thinking that the agent of multiple myeloma person's intravenous contrast was anti-indication.But find that CAN incidence rate is only 0.6% ~ 1.25% in the observation after one group of retrospective multiple myeloma accepts contrast agent.Therefore if desired clinical, carefully monitor, still can carry out after supplementing capacity.(8) apply other nephrotoxic drugs simultaneously.(9) multiple radiocontrast medium person is accepted in a short time.(10) dosage of contrast agent: dosage is larger, renal damage increases, and as dosage > 30ml, during radiography, mean blood pressure is less than 13.3kPa (100mmHg) then dangerous increase.(11) hypercalcemia.2, possible risk factor; (1) age: because People nephron reduces and the reduction of renal blood flow, GFR declined with the age, and CAN incidence rate is high.(2) diabetics of absent renal function infringement.(3) anemia.(4) albuminuria (without nephrotic syndrome).(5) abnormal liver function.(6) hyperuricemia.(7) male patient.(8) hypertension.(9) renal transplantation person is accepted.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of Chinese medicine preparation and preparation method of preventing radiographic contrast nephropathy, and Chinese medicine preparation of the present invention has definite curative effect to prevention radiographic contrast nephropathy, and effective percentage is high, instant effect, toxic and side effects are little and relapse rate is low.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation preventing radiographic contrast nephropathy, each raw medicinal material of described Chinese medicine preparation comprises: Symplocoris Paniculatae, Cupressaceae root, Folium rhoeinis, burden seven, flat fruit, Partition in Fructus Juglandis, Habenaria tenaculata Reichb, Caulis Parameriae Laevigatae, Rhizoma Tupistrae Chinensis, Folium Photiniae (Folium Photiniae serrulatae), Pilus Sus domestica pin, Semen glycines sojae, Suffrutescent Securinega Twig, Spongilla, Herba Herminii bulleyi, Dendrobium densiflorum lindl., musk orchid and Radix seu Herba Spiranthis Lanceae.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Symplocoris Paniculatae 5 ~ 15 parts, Cupressaceae root 10 ~ 20 parts, Folium rhoeinis 10 ~ 15 parts, burden 75 ~ 15 parts, flat fruit 15 ~ 20 parts, Partition in Fructus Juglandis 10 ~ 15 parts, Habenaria tenaculata Reichb 20 ~ 30 parts, Caulis Parameriae Laevigatae 15 ~ 20 parts, Rhizoma Tupistrae Chinensis 10 ~ 25 parts, Folium Photiniae (Folium Photiniae serrulatae) 5 ~ 15 parts, 10 ~ 20 parts, Pilus Sus domestica pin, Semen glycines sojae 15 ~ 25 parts, Suffrutescent Securinega Twig 5 ~ 15 parts, Spongilla 15 ~ 25 parts, Herba Herminii bulleyi 20 ~ 30 parts, Dendrobium densiflorum lindl. 10 ~ 20 parts, musk orchid 20 ~ 35 parts and Radix seu Herba Spiranthis Lanceae 15 ~ 25 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be as follows: Symplocoris Paniculatae 5 ~ 10 parts, Cupressaceae root 15 ~ 20 parts, Folium rhoeinis 12 ~ 15 parts, burden 75 ~ 10 parts, flat fruit 15 ~ 18 parts, Partition in Fructus Juglandis 12 ~ 15 parts, Habenaria tenaculata Reichb 25 ~ 30 parts, Caulis Parameriae Laevigatae 17 ~ 20 parts, Rhizoma Tupistrae Chinensis 15 ~ 25 parts, Folium Photiniae (Folium Photiniae serrulatae) 10 ~ 15 parts, 15 ~ 20 parts, Pilus Sus domestica pin, Semen glycines sojae 20 ~ 25 parts, Suffrutescent Securinega Twig 10 ~ 15 parts, Spongilla 18 ~ 25 parts, Herba Herminii bulleyi 25 ~ 30 parts, Dendrobium densiflorum lindl. 15 ~ 20 parts, musk orchid 25 ~ 35 parts and Radix seu Herba Spiranthis Lanceae 20 ~ 25 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is most preferably as follows: Symplocoris Paniculatae 6 parts, Cupressaceae root 19 parts, Folium rhoeinis 12 parts, burden 79 parts, flat fruit 15 parts, Partition in Fructus Juglandis 14 parts, Habenaria tenaculata Reichb 28 parts, Caulis Parameriae Laevigatae 17 parts, Rhizoma Tupistrae Chinensis 24 parts, Folium Photiniae (Folium Photiniae serrulatae) 11 parts, 20 parts, Pilus Sus domestica pin, Semen glycines sojae 21 parts, Suffrutescent Securinega Twig 14 parts, Spongilla 20 parts, Herba Herminii bulleyi 25 parts, Dendrobium densiflorum lindl. 19 parts, musk orchid 28 parts and Radix seu Herba Spiranthis Lanceae 24 parts.

In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is most preferably as follows: Symplocoris Paniculatae 8 parts, Cupressaceae root 16 parts, Folium rhoeinis 13 parts, burden 77 parts, flat fruit 18 parts, Partition in Fructus Juglandis 12 parts, Habenaria tenaculata Reichb 26 parts, Caulis Parameriae Laevigatae 19 parts, Rhizoma Tupistrae Chinensis 18 parts, Folium Photiniae (Folium Photiniae serrulatae) 13 parts, 17 parts, Pilus Sus domestica pin, Semen glycines sojae 25 parts, Suffrutescent Securinega Twig 11 parts, Spongilla 23 parts, Herba Herminii bulleyi 28 parts, Dendrobium densiflorum lindl. 15 parts, musk orchid 33 parts and Radix seu Herba Spiranthis Lanceae 22 parts.

When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Beneficial effect of the present invention: Chinese medicine preparation of the present invention, has determined curative effect, the advantage that toxic and side effects is little to prevention radiographic contrast nephropathy.

Detailed description of the invention

The invention provides a kind of Chinese medicine preparation preventing radiographic contrast nephropathy, its raw medicinal material comprises: Symplocoris Paniculatae, Cupressaceae root, Folium rhoeinis, burden seven, flat fruit, Partition in Fructus Juglandis, Habenaria tenaculata Reichb, Caulis Parameriae Laevigatae, Rhizoma Tupistrae Chinensis, Folium Photiniae (Folium Photiniae serrulatae), Pilus Sus domestica pin, Semen glycines sojae, Suffrutescent Securinega Twig, Spongilla, Herba Herminii bulleyi, Dendrobium densiflorum lindl., musk orchid and Radix seu Herba Spiranthis Lanceae.

In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:

Symplocoris Paniculatae: [another name] arsenicum, Oviductus Ranae saliva, spend tea in vain, Herba Eleusines Indicae, wingceltis cyanine .[originate] medical material Ji Yuan: be the root of Symplocaceae plant Symplocoris Paniculatae, leaf, flower or seed.[nature and flavor] are bitter; Cold nature.[function cures mainly] heat-clearing and toxic substances removing; Regulating QI eliminating stagnation; Dispelling wind for relieving itching.Main mastitis; Lymphadenitis; Intestinal carbuncle; Furuncle; Hernia; Urticaria; Skin pruritus.[extracts] " China's book on Chinese herbal medicine "

Cupressaceae root: [source] medical material Ji Yuan: be the root of Cupressaceae plant Cupressus funebris Endl..[nature and flavor] are bitter; Pungent; Cool in nature.[function cures mainly] heat-clearing and toxic substances removing.Djumah rash fever of the body does not move back.[extracts] " China's book on Chinese herbal medicine "

Folium rhoeinis: [another name] purple Folium Rohdeae Japonicae, freshwater mussel floral leaf, red Folium rhoeinis.[source] medical material Ji Yuan: be the leaf of the purple Rohdea japonica Roth of Commelianaceae plant.[nature and flavor] are sweet; Cool; Light.[function cures mainly] heat-clearing and toxic substances removing; Removing stasis to stop bleeding.Main cough due to lung-heat; Spit blood; Epistaxis; Have blood in stool; Dysentery; Traumatic injury; Scrofula; Furuncle.[extracts] " China's book on Chinese herbal medicine "

Burden seven: [another name] half bowl of water, Schisandra propinqua (Wall.) Baill. Var. intermedia A. Smith, BAOFULIAN, one piece of brick.[source] medical material Ji Yuan: be the root welding technology of Berberidaceae vegetation water Radix et Rhizoma Dysosmatis.[nature and flavor] bitter in the mouth; Pungent; Cool in nature; Poisonous.[return through] lung; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Dissipating phlegm and resolving masses; Stasis-dispelling and pain-killing.Main laryngopharynx swelling and pain; Carbuncle; Furuncle; Pneumonia; Parotitis; Venom; Scrofula; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "

Flat fruit: [another name] Flos dendrobenthamiae angustatae.[source] medical material Ji Yuan: be bark, the fruit of Anacardiaceae plant SANYE paint.[nature and flavor] skin: bitter in the mouth, puckery; Cool.[function cures mainly] heat-clearing and toxic substances removing; Convergence; Hemostasis.Main laryngopharynx swelling and pain; Spit blood; Dysentery.[extracts] " China's book on Chinese herbal medicine "

Partition in Fructus Juglandis: [another name] Semen Juglandis clothing (" book on Chinese herbal medicine is new again "), cracker (" modern Practical Chinese medicinal "), Semen Juglandis is every (" Shandong Chinese herbal medicine handbook ").[source] is the wooden barrier film in juglandaceae plant Semen Juglandis pit.[nature and flavor] " book on Chinese herbal medicine is new again ": " bitter and puckery flavor, property is put down, nontoxic." [return through] " book on Chinese herbal medicine is new again ": " enters spleen, kidney two warp." [function cures mainly] reinforcing the kindey to control nocturnal emission.Control seminal emission lingering diarrhea, gonorrhea, hematuria, incontinence of urine, metrorrhagia, leukorrhagia, dysentery." book on Chinese herbal medicine is new again ": " spleen benefiting and strengthen kidney." [extracts] " Chinese medicine voluminous dictionary "

Habenaria tenaculata Reichb: the beautiful phoenix flower of [another name] ovum gallinaceum ginseng, antenna.[source] the orchid family Habenaria tenaculata Reichb Habenaria tentaculata Reichb.f., is used as medicine with tuber.[function cures mainly] pain relieving, antiinflammatory, granulation promoting, hemostasis, circulation of qi promoting, the kidney invigorating.[extracts] " national Chinese herbal medicine compilation "

Caulis Parameriae Laevigatae: [another name] filamentary silver Cortex Eucommiae (" choosing of Simao, Yunnan Chinese herbal medicine "), he when Du (Dai Nationality's name).The stem that [source] is apocynaceae plant meropodium pearl or peel of stem.The whole year can adopt.[nature and flavor] are bitter sweet, flat.[function cures mainly] hemostasis and anti-inflammation, strong warm the kidney invigorating.[extracts] " Chinese medicine voluminous dictionary "

Rhizoma Tupistrae Chinensis: [another name] Tupistra chinensis Bak., Herba Herminii, Niu Dangcan.[source] medical material Ji Yuan: be the band rhizome herb of orchid musk orchid.[nature and flavor] sweet in the mouth; Warm in nature.[function cures mainly] kidney and spleen invigorating; Regulating menstruation and activating blood; Removing toxic substances.Main giddy insomnia; Irritated thirsty; Anorexia; Menoxenia; Venom.[extracts] " China's book on Chinese herbal medicine "

Folium Photiniae (Folium Photiniae serrulatae): [another name] wind medicine (" detailed outline "), Folium Photiniae (Folium Photiniae serrulatae) (" Bencao Congxin "), goldenrain tree tea (" detailed outline lifts something lost "), Rhizophora apiculata Blume leaf, stone rock leaves (" Chinese crude drug handbook ").[source] is the dried leaves of rosaceous plant Chinese photinia.The whole year can adopt.After drying, be bundled into wisp.[nature and flavor] work hard, flat.[return through] enters liver, kidney channel.[function cures mainly] dispels the wind, dredging collateral, kidney tonifying.Control migratory arthralgia, aching pain in waist and back, flaccidity of the lower limbs of suffering from a deficiency of the kidney, migraine, rubella.To dispel the wind the kidney invigorating.For bones and muscles pain due to rheumatism, impotence and seminal emission.[extracts] " Chinese medicine voluminous dictionary "

Pilus Sus domestica pin: [another name] Adiantum capillus-junosis, Adiantum capillus-junosis Rupr., Herba Adianti, bristles seven, black foot awns, rock Herba Spirodelae.[source] fern adiantaceae Pilus Sus domestica pin Adiantum capillus junosis Rupr., is used as medicine with herb, root.[nature and flavor] micro-hardship, cool.[function cures mainly] clearing away heat and promoting diuresis, relaxing muscles and tendons and activating QI and blood in the collateral, the kidney invigorating cough-relieving.Cure mainly stranguria with blood, urine retention, mastitis, seminal emission, cough.[extracts] " national Chinese herbal medicine compilation "

Semen glycines sojae: [another name] zero black bean, SEMEN GLYCINE (" book on Chinese herbal medicine converge speech "), thin Semen sojae atricolor, checks bean, material bean (" herbal classic is met former "), horsebean (" book on Chinese herbal medicine is through separating ").[source] is the seed of leguminous plant Lao bean.During fruit maturation in autumn, extract Herb, dry, open fruit pod, collect seed, then shine to foot dry.[nature and flavor] are sweet, cool.[return through] 1. " herbal classic is met former ": " enter kidney channel blood system." 2. " book on Chinese herbal medicine is through separating ": " enters lung meridian, spleen meridian." [function cures mainly] liver and kidney tonifying, removing toxic substances of dispeling the wind.Control and cloudy lose blurred vision, lumbago due to renal deficiency, night sweat, bones and muscles pain, puerperal puerperal tetanus, infant malnutrition.[extracts] " Chinese medicine voluminous dictionary "

Suffrutescent Securinega Twig: [another name] Cacumen Securinegae Suffruticosae, Canis familiaris L. Fructus Pruni bar, Hua Zhou bar, mountain sweep bar, old, stale rice drink, false Fortunella crassifolia Swingle rattan.[source] is euphorbia plant Suffrutescent Securinega Twig, is used as medicine with Ye Jihua.The wild product spring and summer autumn all can gather, and Securan-11-one. content of gathering before blooming spring is the highest, is cut off by branch, beat, get its twig and leaf after drying apart from 2 ~ 3 cun, earth's surface place.[nature and flavor] are sweet, bitter, flat.[function cures mainly] expelling wind and activating blood circulation, the strong muscle of the kidney invigorating.For facial paralysis, poliomyelitis sequela, dizzy, deaf, neurasthenia, lethargy, sexual impotence.[extracts] " national Chinese herbal medicine compilation "

Spongilla: [another name] spongilla (" Suzhou this product medical material ").[source] is the dry colony of the crisp spongilla sp of Spongillidae animal.Autumn, winter, cut two ends branch, removing weeds, dried in riverbed or lakeside pickup.[nature and flavor] " detailed outline ": " sweet, temperature, nontoxic." [function cures mainly] Yiyang arresting seminal emission.Control sexual impotence, seminal emission, nebulousurine, leukorrhagia, incontinence of urine, eczema scrotum.[extracts] " Chinese medicine voluminous dictionary "

Herba Herminii bulleyi: [another name] little Zong township.[source] medical material Ji Yuan: be the herb of orchid bar leaf musk orchid.[nature and flavor] are sweet; Temperature.[return through] kidney channel.[function cures mainly] warming and recuperating the kidney-YANG.Main soreness of the waist and knees; Sexual impotence; Seminal emission.[extracts] " China's book on Chinese herbal medicine "

Dendrobium densiflorum lindl.: [another name] Radix Et Rhizoma Rhei, Dendrobium denneanum Kerr., dendrobium.[source] the orchid family Dendrobium densiflorum lindl., is used as medicine with stem.[nature and flavor] are sweet, light, micro-salty, cold.[function cures mainly] nourishing YIN for benefiting the kidney, promoting the production of body fluid to quench thirst.Aranea calentura, impairment of body fluid, xerostomia excessive thirst, weak after being ill.[extracts] " national Chinese herbal medicine compilation "

Musk orchid: [another name] Rhizoma Tupistrae Chinensis, Herba Herminii.[source] the orchid family Herminium plant musk orchid Herminium monorchis (L.) R.Brown., is used as medicine with whole herb with root.Autumn excavates, and dries.[nature and flavor] are sweet, temperature.[function cures mainly] enriching yin and nourishing kidney, nourishing the stomach, regulating menstruation.For neurasthenia, dizzy insomnia, irritated thirsty inappetence, early whitening of beard and hair, menoxenia.[extracts] " national Chinese herbal medicine compilation "

Radix seu Herba Spiranthis Lanceae: [another name] Radix seu Herba Spiranthis Lanceae, imperial thick pillar, interwined dragon grass, two coral grass.[source] the orchid family Spiranthes plant Radix seu Herba Spiranthis Lanceae Spiranthes australis (R.Brown.) Lindl., with root, all herbal medicine.Autumn uproots, and removing stem and leaf, cleans and dry.Spring and summer is gathered herb, cleans and dries.[nature and flavor] are sweet, light, flat.[function cures mainly] enriching yin boost qi, removing pathogenic heat from blood and toxic substance from the body.For body is empty after being ill, neurasthenia, hemoptysis of pulmonary tuberculosis, laryngopharynx swelling and pain, Infantile Summer Fever, diabetes, leucorrhea; Venom is controlled in external.[extracts] " national Chinese herbal medicine compilation "

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Symplocoris Paniculatae 5 ~ 15 parts, Cupressaceae root 10 ~ 20 parts, Folium rhoeinis 10 ~ 15 parts, burden 75 ~ 15 parts, flat fruit 15 ~ 20 parts, Partition in Fructus Juglandis 10 ~ 15 parts, Habenaria tenaculata Reichb 20 ~ 30 parts, Caulis Parameriae Laevigatae 15 ~ 20 parts, Rhizoma Tupistrae Chinensis 10 ~ 25 parts, Folium Photiniae (Folium Photiniae serrulatae) 5 ~ 15 parts, 10 ~ 20 parts, Pilus Sus domestica pin, Semen glycines sojae 15 ~ 25 parts, Suffrutescent Securinega Twig 5 ~ 15 parts, Spongilla 15 ~ 25 parts, Herba Herminii bulleyi 20 ~ 30 parts, Dendrobium densiflorum lindl. 10 ~ 20 parts, musk orchid 20 ~ 35 parts and Radix seu Herba Spiranthis Lanceae 15 ~ 25 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Symplocoris Paniculatae 5 ~ 10 parts, Cupressaceae root 15 ~ 20 parts, Folium rhoeinis 12 ~ 15 parts, burden 75 ~ 10 parts, flat fruit 15 ~ 18 parts, Partition in Fructus Juglandis 12 ~ 15 parts, Habenaria tenaculata Reichb 25 ~ 30 parts, Caulis Parameriae Laevigatae 17 ~ 20 parts, Rhizoma Tupistrae Chinensis 15 ~ 25 parts, Folium Photiniae (Folium Photiniae serrulatae) 10 ~ 15 parts, 15 ~ 20 parts, Pilus Sus domestica pin, Semen glycines sojae 20 ~ 25 parts, Suffrutescent Securinega Twig 10 ~ 15 parts, Spongilla 18 ~ 25 parts, Herba Herminii bulleyi 25 ~ 30 parts, Dendrobium densiflorum lindl. 15 ~ 20 parts, musk orchid 25 ~ 35 parts and Radix seu Herba Spiranthis Lanceae 20 ~ 25 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Symplocoris Paniculatae 6 parts, Cupressaceae root 19 parts, Folium rhoeinis 12 parts, burden 79 parts, flat fruit 15 parts, Partition in Fructus Juglandis 14 parts, Habenaria tenaculata Reichb 28 parts, Caulis Parameriae Laevigatae 17 parts, Rhizoma Tupistrae Chinensis 24 parts, Folium Photiniae (Folium Photiniae serrulatae) 11 parts, 20 parts, Pilus Sus domestica pin, Semen glycines sojae 21 parts, Suffrutescent Securinega Twig 14 parts, Spongilla 20 parts, Herba Herminii bulleyi 25 parts, Dendrobium densiflorum lindl. 19 parts, musk orchid 28 parts and Radix seu Herba Spiranthis Lanceae 24 parts.

Wherein, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation can be preferably as follows: Symplocoris Paniculatae 8 parts, Cupressaceae root 16 parts, Folium rhoeinis 13 parts, burden 77 parts, flat fruit 18 parts, Partition in Fructus Juglandis 12 parts, Habenaria tenaculata Reichb 26 parts, Caulis Parameriae Laevigatae 19 parts, Rhizoma Tupistrae Chinensis 18 parts, Folium Photiniae (Folium Photiniae serrulatae) 13 parts, 17 parts, Pilus Sus domestica pin, Semen glycines sojae 25 parts, Suffrutescent Securinega Twig 11 parts, Spongilla 23 parts, Herba Herminii bulleyi 28 parts, Dendrobium densiflorum lindl. 15 parts, musk orchid 33 parts and Radix seu Herba Spiranthis Lanceae 22 parts.

When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to its quality 0.1 ~ 0.3 times of microcrystalline Cellulose, 0.05 ~ 0.15 times of lactose, 0.1 ~ 0.3 times of starch, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

When the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1: tablet

Get Symplocoris Paniculatae 60g, Cupressaceae root 190g, Folium rhoeinis 120g, burden seven 90g, flat fruit 150g, Partition in Fructus Juglandis 140g, Habenaria tenaculata Reichb 280g, Caulis Parameriae Laevigatae 170g, Rhizoma Tupistrae Chinensis 240g, Folium Photiniae (Folium Photiniae serrulatae) 110g, Pilus Sus domestica pin 200g, Semen glycines sojae 210g, Suffrutescent Securinega Twig 140g, Spongilla 200g, Herba Herminii bulleyi 250g, Dendrobium densiflorum lindl. 190g, musk orchid 280g and Radix seu Herba Spiranthis Lanceae 240g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 95%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 300 object micropowders;

3rd step, by the micropowders that second step obtains, adds relative to the microcrystalline Cellulose of its quality 0.1 times, 0.05 times of lactose, the starch of 0.1 times, sieves, mix homogeneously, granulates, dry, adds relative to micropowders quality 0.005 times of magnesium stearate, granulate, tabletting, makes.

Embodiment 2: capsule

Get Symplocoris Paniculatae 80g, Cupressaceae root 160g, Folium rhoeinis 130g, burden seven 70g, flat fruit 180g, Partition in Fructus Juglandis 120g, Habenaria tenaculata Reichb 260g, Caulis Parameriae Laevigatae 190g, Rhizoma Tupistrae Chinensis 180g, Folium Photiniae (Folium Photiniae serrulatae) 130g, Pilus Sus domestica pin 170g, Semen glycines sojae 250g, Suffrutescent Securinega Twig 110g, Spongilla 230g, Herba Herminii bulleyi 280g, Dendrobium densiflorum lindl. 150g, musk orchid 330g and Radix seu Herba Spiranthis Lanceae 220g.

Its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 85%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 3 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.5:0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 28g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, fasting 12 hours before experiment, the Chinese medicine preparation tablet dissolved prepared by embodiments of the invention 1 is in water, (concentration is 7.58g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 37.9 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record toxic reaction and the death toll of mice.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet of the present invention and LD50>37.9 crude drug/kg, every day, maximum dosage-feeding was 75.8 crude drugs/kg/ day.Chinese medicine preparation clinical application amount of the present invention be 8.2g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 24g) oral administration gavage Chinese medicine preparation of the present invention is 541 times of quantity.Therefore Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine preparation embodiment 1 tablet of the present invention presses 16.38,24.62 and 36.48g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine preparation of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Prophylactic tria is carried out to the routine radiography patient in the court 168, treatment group 84 example, male 46 example, women 38 example, 24 ~ 67 years old age, the glycosuria patient 4 that wherein routine with original renal insufficiency person 10, the glycosuria patient 5 with renal insufficiency is routine, absent renal function damages is routine, congestive heart failure person 3 is routine, nephrotic syndrome person 5 is routine, hypercalcemia person 3 is routine, anemia person 16 is routine and hyperpietic 18 is routine.Matched group 84 example, male 47 example, women 39 example, 25 ~ 65 years old age, wherein with original renal insufficiency person 9 example, glycosuria patient 4 example, congestive heart failure person 4 example, nephrotic syndrome person 6 example, hypercalcemia person 2 example, anemia person 17 example and hyperpietic 19 example with glycosuria patient 6 example of renal insufficiency, absent renal function infringement.

Therapeutic Method:

Treatment group: the continuous tablet giving the embodiment of the present invention 1 for two days after the radiography same day and radiography, each 4, every day 3 times, and advise patient to drink more water;

Matched group: after 6h and radiography, 6h gives 0.9% sodium chloride solution 1ml/kgh intravenous injection hydration treatment respectively before radiography, and advises patient to drink more water.

Curative effect judging standard: measure respectively and the serum creatinine numerical value of 1 day, 2 days, 3 days, 5 days and 7 days before recording radiography, after radiography, serum creatinine situation of change is as standard before and after radiography.Effective: serum creatinine rises lower than 10%, does not occur oliguria, the clinical symptoms such as anuria; Effective: serum creatinine rises 10% ~ 25%, oliguria, and the clinical symptoms such as anuria do not have substantially; Invalid: serum creatinine rises and is more than or equal to 25%, with oliguria, the clinical symptoms such as anuria.

Therapeutic outcome: observe 7 days after radiography, statistical result is see table 1.

Before and after table 1 radiography, two groups of prevention situations compare (example):

Group	n	Effective	Effectively	Invalid	Effectively total
						Treatment group	84	71	13	0	84(100％)
Matched group	84	39	35	10	74(88.1％)

As can be seen from Table 1, Chinese medicine preparation of the present invention is adopted to prevent radiographic contrast nephropathy, relative to matched group, on therapeutic effect, tool increases significantly, namely Chinese medicine preparation of the present invention effectively can avoid the generation of radiographic contrast nephropathy, even radiography patient have the risk factors such as original renal insufficiency exist time, still there is excellent preventive effect.

Concrete case: thank certain, male, 42 years old, with original renal insufficiency, because cardiovascular needs radiography, the continuous tablet giving the embodiment of the present invention 1 for two days after the radiography same day and radiography, each 4, every day 3 times, after radiography in 7 days, after radiography, the 2nd day serum creatinine is higher by 7% than being increased to before radiography, there is not anuria, the clinical symptoms such as oliguria, after radiography the 4th day, serum creatinine returned to normal level before radiography.

Claims (9)

1. prevent a Chinese medicine preparation for radiographic contrast nephropathy, it is characterized in that, each raw medicinal material of described Chinese medicine preparation comprises: Symplocoris Paniculatae, Cupressaceae root, Folium rhoeinis, burden seven, flat fruit, Partition in Fructus Juglandis, Habenaria tenaculata Reichb, Caulis Parameriae Laevigatae, Rhizoma Tupistrae Chinensis, Folium Photiniae (Folium Photiniae serrulatae), Pilus Sus domestica pin, Semen glycines sojae, Suffrutescent Securinega Twig, Spongilla, Herba Herminii bulleyi, Dendrobium densiflorum lindl., musk orchid and Radix seu Herba Spiranthis Lanceae.

2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Symplocoris Paniculatae 5 ~ 15 parts, Cupressaceae root 10 ~ 20 parts, Folium rhoeinis 10 ~ 15 parts, burden 75 ~ 15 parts, flat fruit 15 ~ 20 parts, Partition in Fructus Juglandis 10 ~ 15 parts, Habenaria tenaculata Reichb 20 ~ 30 parts, Caulis Parameriae Laevigatae 15 ~ 20 parts, Rhizoma Tupistrae Chinensis 10 ~ 25 parts, Folium Photiniae (Folium Photiniae serrulatae) 5 ~ 15 parts, 10 ~ 20 parts, Pilus Sus domestica pin, Semen glycines sojae 15 ~ 25 parts, Suffrutescent Securinega Twig 5 ~ 15 parts, Spongilla 15 ~ 25 parts, Herba Herminii bulleyi 20 ~ 30 parts, Dendrobium densiflorum lindl. 10 ~ 20 parts, musk orchid 20 ~ 35 parts and Radix seu Herba Spiranthis Lanceae 15 ~ 25 parts.

3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Symplocoris Paniculatae 5 ~ 10 parts, Cupressaceae root 15 ~ 20 parts, Folium rhoeinis 12 ~ 15 parts, burden 75 ~ 10 parts, flat fruit 15 ~ 18 parts, Partition in Fructus Juglandis 12 ~ 15 parts, Habenaria tenaculata Reichb 25 ~ 30 parts, Caulis Parameriae Laevigatae 17 ~ 20 parts, Rhizoma Tupistrae Chinensis 15 ~ 25 parts, Folium Photiniae (Folium Photiniae serrulatae) 10 ~ 15 parts, 15 ~ 20 parts, Pilus Sus domestica pin, Semen glycines sojae 20 ~ 25 parts, Suffrutescent Securinega Twig 10 ~ 15 parts, Spongilla 18 ~ 25 parts, Herba Herminii bulleyi 25 ~ 30 parts, Dendrobium densiflorum lindl. 15 ~ 20 parts, musk orchid 25 ~ 35 parts and Radix seu Herba Spiranthis Lanceae 20 ~ 25 parts.

4. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Symplocoris Paniculatae 6 parts, Cupressaceae root 19 parts, Folium rhoeinis 12 parts, burden 79 parts, flat fruit 15 parts, Partition in Fructus Juglandis 14 parts, Habenaria tenaculata Reichb 28 parts, Caulis Parameriae Laevigatae 17 parts, Rhizoma Tupistrae Chinensis 24 parts, Folium Photiniae (Folium Photiniae serrulatae) 11 parts, 20 parts, Pilus Sus domestica pin, Semen glycines sojae 21 parts, Suffrutescent Securinega Twig 14 parts, Spongilla 20 parts, Herba Herminii bulleyi 25 parts, Dendrobium densiflorum lindl. 19 parts, musk orchid 28 parts and Radix seu Herba Spiranthis Lanceae 24 parts.

5. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Symplocoris Paniculatae 8 parts, Cupressaceae root 16 parts, Folium rhoeinis 13 parts, burden 77 parts, flat fruit 18 parts, Partition in Fructus Juglandis 12 parts, Habenaria tenaculata Reichb 26 parts, Caulis Parameriae Laevigatae 19 parts, Rhizoma Tupistrae Chinensis 18 parts, Folium Photiniae (Folium Photiniae serrulatae) 13 parts, 17 parts, Pilus Sus domestica pin, Semen glycines sojae 25 parts, Suffrutescent Securinega Twig 11 parts, Spongilla 23 parts, Herba Herminii bulleyi 28 parts, Dendrobium densiflorum lindl. 15 parts, musk orchid 33 parts and Radix seu Herba Spiranthis Lanceae 22 parts.

6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

7. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.

8. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, by the micropowders that second step obtains, add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, 0.05 ~ 0.15 times of lactose, the starch of 0.1 ~ 0.3 times, sieve, mix homogeneously, granulate, drying, adds relative to micropowders quality 0.005 ~ 0.05 times of magnesium stearate, granulate, tabletting, makes.

9. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:

The first step, is mixed in proportion each for described Chinese medicine preparation raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;

3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.