CN1048868C - Cod liver oil emulsion and its preparation - Google Patents
Cod liver oil emulsion and its preparation Download PDFInfo
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- CN1048868C CN1048868C CN94113650A CN94113650A CN1048868C CN 1048868 C CN1048868 C CN 1048868C CN 94113650 A CN94113650 A CN 94113650A CN 94113650 A CN94113650 A CN 94113650A CN 1048868 C CN1048868 C CN 1048868C
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- vitamin
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- antiseptic
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Abstract
The present invention discloses an emulsion containing vitamin A, D and E, vegetable oil, emulsifying agents, antioxidants, preservative agents, thickening agents and water. The emulsion of the present invention has the advantages of good dispersivity and high stability. The emulsion can be taken directly or added into fresh milk to form stable strengthened milk. If taken for a long time, the emulsion can improve organism immunity and prevent and treat diseases caused by deficiency or shortage of vitamin A, D, E and K.
Description
The present invention relates to a kind of emulsion formulation, particularly a kind of emulsion formulation that contains vitamin A, D, E.
As everyone knows, vitamin is to keep the necessary organic compound of human body normal physiological function, the long-term lacking of certain vitamin or can not cause metabolism disorder and pathological state completely.Vitamin A, D, E, K are fatsoluble vitamiies, as vitamin A long-term lacking or deficiency, conjunctival exerosis nyctalopia can appear,, severe patient can cause keratomalacia even perforation, blind, and influences the normal development of epithelial tissue and skeleton and reduce immune function of human body.An amount of vitamin A that replenishes can reduce the incidence and mortality of common respiratory tract infection of child and stomachache and the sickness rate of reduction adult certain cancers.The shortage of vitamin D can cause rickets to the child, and the anemia of pregnant woman then can cause osteomalacia and senile osteoporosis to being grown up especially.Vitamin E is an effective anti-oxidants, and it can protect the unsaturated fatty acid of erythrocyte membrane to avoid oxidation, prevents hematoclasis and avoids haemolysis, and the function of keeping cardiac muscle, skeleton machine, smooth muscle and peripheral vascular system is played an important role.Premature labor baby vitamin E deficiency can cause hemolytic anemia, and the bad infant of fat absorption can have vitamin E deficiency.Vitamin E also has anti-aging effects.Vitamin K is essential to the human body coagulation function, has a plurality of thrombins to rely on it.Vitamin K can be prevented and treated neonate and delayed hemorrhage disease, and patient and old people that the patient that takes medicines such as antuepileptic, antitubercular agent for a long time and intestinal absorption function are reduced also have the hemorrhage effect of prevention.It is few that breast milk and milk powder contain vitamin K, can cause tardy property hemorrhagic disease of newborn, and just internal hemorrhage is arranged more, is in a bad way.
At present, China treats and prevents vitamin A such as infant rickets, anemia of pregnant woman's osteomalacia, senile osteoporosis, D to lack the property disease, mainly adopts vitamin D2, the D3 of cod-liver oil and preparation thereof and injection.But there is following problem: because cod-liver oil has abnormal flavour to be difficult for being accepted by infant; Because belonging to fat-soluble oil preparation is difficult for being absorbed by human consumption; Easily cause deficiency, excessive or poisoning owing to dose is wayward; Be difficult for adhering to owing to must take every day to bring inconvenience and easily pass into silence to the child head of a family.
An object of the present invention is to provide and a kind ofly can directly orally can add the vitamin emulsion formulation of making fortified milk in the milk again to.
Another object of the present invention provides a kind of fortified milk goods that contain described emulsion formulation.
Emulsion formulation of the present invention contains vegetable oil, emulsifying agent, Butylated hydroxyanisole, butylated hydroxy-a aldehyde, antiseptic, thickening agent, vitamin A, vitamin D, vitamin E and water.The preferred content of described component (weight) is as follows:
Vegetable oil 6-8%
Emulsifying agent 8-12%
Butylated hydroxyanisole 60-100ppm
Butylated hydroxy-a aldehyde 60-100ppm
Antiseptic 0.1-0.2%
Thickening agent 0.1-0.2%
Vitamin A 8-22 ten thousand IU/10ml emulsion formulations
Vitamin D 2.8-6.6 ten thousand IU/10ml emulsion formulations
Vitamin E 36-84IU/10ml emulsion formulation
Surplus is a water
Described preparation can further contain citric acid, preferred 30-50ppm.
Emulsion formulation of the present invention also can further contain vitamin K, and it measures preferred 3.6-8.0mg/10ml emulsion formulation.
A kind of preparation method of described emulsion formulation is for to add distilled water, thickening agent, antiseptic, Butylated hydroxyanisole, butylated hydroxy-a aldehyde etc. with vegetable oil, emulsifying agent, vitamin behind 50-60 ℃ of mix homogeneously, after fully mixing, handle through homogenizing, obtain uniform and stable emulsion.
Vegetable oil in the emulsion formulation of the present invention makes vitamin A, D, E, K fully dissolving, homodisperse and make emulsion-stabilizing in emulsion, can comprise that various plants oil is as Oleum Brassicae campestris, Semen arachidis hypogaeae wet goods.
Described emulsifying agent can be that any vitamin homodisperse that promotes forms the material of emulsion, and preferred solvent is formed Oleum Brassicae campestris glyceride or sorbester p17 by Oleum Brassicae campestris glyceride or sorbester p17 and Tween 80: Tween 80 is 1: 1.5-3 (weight ratio).
Because vitamin A, D, E, K are subjected to the influence of various extraneous factors such as light, heat, oxygen, particularly to light, oxygen instability, so will dose antioxidant Butylated hydroxyanisole, butylated hydroxy-a aldehyde and aid anti-oxidants citric acid.
Described antiseptic can be any material that can suppress bacterial growth in the emulsion formulation.Because vitamin A, D, E, K emulsion formulation itself are the good environment of bacterial growth, and antibacterial not only can be harmful, also can influence viscosity, the destruction stability of emulsion of emulsion, so need to add antiseptic.Preferred antiseptic is sorbic acid or calcium propionate.
Described thickening agent can be any material that can increase the viscosity of emulsion.Preferred thickening is sodium alginate or sodium carboxymethyl cellulose, and they not only play the thickening agent effect, also plays stabilizer function, can suppress creaming.
Vitamin E wherein also can prevent the oxidation of vitamin A, D, prolongs the effect duration of Emulsion.
The emulsion formulation good dispersion that contains vitamin A, D, E etc. of the present invention, stability is high, both can be directly oral, can add the stable fortified milk of formation in the milk again, the preferred every liter of milk of adding proportion adds the 0.1ml emulsion formulation.Emulsion formulation of the present invention does not have influence to physicochemical character, taste and the color and luster of milk.Take the vitamin enrichment milk that is made into and then be the way of safe, easy, the easy row that replenishes vitamin A, D, E etc. in the human body.Said preparation has the effect that improves nutritional value of milk, strengthens the human quality.
Emulsion formulation of the present invention is taken for a long time can human body immunity improving power, reduce respiratory tract, digestive tract disease sickness rate, reduce neonate and infant mortality rate, can prevent and treat rickets, osteomalacia, promote calcium, phosphorus to absorb, help prevention and treatment senile osteoporosis, nyctalopia, xerophthalmia etc.Maternity dress is with the back neonate height of giving birth to, and body weight all has and increases.A, D, E unite use and still have effect anticancer, defying age.
The manufacture method of emulsion formulation of the present invention is simple, good stability, and technology is rationally reliable.
Further describe the present invention below in conjunction with embodiment.
Particularly point out as nothing, used proportioning is a weight ratio.Embodiment 1
Press following formulated emulsion formulation of the present invention:
Oleum Brassicae campestris 7%
Emulsifying agent 10%
Butylated hydroxyanisole 80ppm
Butylated hydroxy-a aldehyde 80ppm
Citric acid 40ppm
Calcium propionate 0.15%
Sodium carboxymethyl cellulose 0.15%
Vitamin A 200,000 IU/10ml Emulsions
Vitamin D 60,000 IU/10ml Emulsions
Vitamin E 40IU/10ml Emulsion
Surplus is a distilled water
Wherein emulsifying agent is made up of sorbester p17 and Tween 80, the weight ratio sorbester p17: Tween 80 is 1: 2.
Preparation method adds distilled water and other described material for emulsifying agent, Oleum Brassicae campestris, described vitamin are mixed at 55 ℃, does the homogenizing processing after fully mixing and obtains uniform and stable emulsion.Embodiment 2
Press embodiment 1 preparation emulsion formulation of the present invention, different is to contain 4mg vitamin k/10ml Emulsion in addition.Embodiment 3
Press embodiment 1 preparation emulsion formulation of the present invention, different is to replace calcium propionate with sorbic acid.Embodiment 4
Press embodiment 1 preparation emulsion formulation of the present invention, different is to replace sodium carboxymethyl cellulose with sodium alginate.Embodiment 5
Press embodiment 1 to 4 preparation emulsion formulation of the present invention, the ratio that adds the 0.1ml emulsion formulation with every liter of fresh milk adds in the milk, makes uniform and stable vitamin enrichment milk, but drinks every day.Also can be processed into milk powder according to a conventional method by this milk.
Embodiment 1 to 4 prepared emulsion formulation can be directly oral as oral liquid, also can add behind the sweeting agent oral.The maternity dress time spent can pregnant July and JIUYUE respectively obey 10ml.Generally can take 5-10ml in every month.
Claims (9)
1, a kind of emulsion formulation is characterized in that containing vegetable oil, emulsifying agent, Butylated hydroxyanisole, butylated hydroxy-a aldehyde, antiseptic, thickening agent, vitamin A, vitamin D, vitamin E and water, and the content of described composition (weight) is as follows:
Vegetable oil 6-8%
Emulsifying agent 8-12%
Butylated hydroxyanisole 60-100ppm
Butylated hydroxy-a aldehyde 60-100ppm
Antiseptic 0.1-0.2%
Thickening agent 0.1-0.2%
Vitamin A 8-22 ten thousand IU/10ml emulsion formulations
Vitamin D 2.8-6.6 ten thousand IU/10ml emulsion formulations
Vitamin E 36-84IU/10ml emulsion formulation
Surplus is a water
2, emulsion formulation as claimed in claim 1 is characterized in that further containing the citric acid of 30-50mmp.
3, emulsion formulation as claimed in claim 1 is characterized in that further containing the vitamin K of 3.6-8.0mg/10ml emulsion formulation.
4, emulsion formulation as claimed in claim 1 is characterized in that described emulsifying agent is made up of Oleum Brassicae campestris glyceride or sorbester p17 and Tween 80.
5, emulsion formulation as claimed in claim 4, the weight ratio that it is characterized in that described Oleum Brassicae campestris glyceride or sorbester p17 and Tween 80 is 1: 1.5-3.
6, emulsion formulation as claimed in claim 1 is characterized in that described antiseptic is sorbic acid or calcium propionate.
7, emulsion formulation as claimed in claim 1 is characterized in that described thickening agent is sodium alginate or Carboxymethyl cellulose sodium.
8, a kind of preparation method of the emulsion formulation as one of claim 1 to 7, it is characterized in that vegetable oil, emulsifying agent, vitamin are added distilled water, thickening agent, antiseptic, Butylated hydroxyanisole, butylated hydroxy-a aldehyde etc. behind 50-60 ℃ of mix homogeneously, after fully mixing, after homogenizing is handled, obtain uniform and stable emulsion.
9, a kind of fortified milk is characterized in that containing the emulsion formulation and the milk of one of claim 1 to 7.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94113650A CN1048868C (en) | 1994-11-30 | 1994-11-30 | Cod liver oil emulsion and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94113650A CN1048868C (en) | 1994-11-30 | 1994-11-30 | Cod liver oil emulsion and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1116925A CN1116925A (en) | 1996-02-21 |
| CN1048868C true CN1048868C (en) | 2000-02-02 |
Family
ID=5036788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94113650A Expired - Fee Related CN1048868C (en) | 1994-11-30 | 1994-11-30 | Cod liver oil emulsion and its preparation |
Country Status (1)
| Country | Link |
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| CN (1) | CN1048868C (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19642359A1 (en) * | 1996-10-14 | 1998-04-16 | Basf Ag | Stable emulsions and dry powder from mixtures of fat-soluble vitamins, their production and use |
| CN1883469B (en) * | 2006-05-26 | 2011-07-20 | 武汉远大制药集团有限公司 | An ocular microemulsion containing Vitamin A and Vitamin E and preparation method thereof |
| CN102119943B (en) * | 2011-03-08 | 2012-06-27 | 中国林业科学研究院资源昆虫研究所 | Moringa oil emulsion |
| CN102302168B (en) * | 2011-05-19 | 2012-09-05 | 四川内江汇鑫制药有限公司 | Vitamin d2 oil and preparation method thereof |
| CN102948482A (en) * | 2012-05-20 | 2013-03-06 | 张伟 | Health care milk for increasing height of teenagers |
| CN104000832B (en) * | 2014-06-11 | 2016-08-17 | 青岛双鲸药业有限公司 | A kind of preparation method of three-dimensional emulsio olei jecoris piscis |
| CN104000780B (en) * | 2014-06-11 | 2016-03-23 | 青岛双鲸药业有限公司 | A kind of three-dimensional emulsio olei jecoris piscis |
| CN104257694A (en) * | 2014-10-14 | 2015-01-07 | 中山百鸥医药科技有限公司 | Cod-liver oil emulsion and preparation method thereof |
| CN105768109A (en) * | 2016-02-25 | 2016-07-20 | 李宏 | Vitamin D and calcium-containing microemulsion as well as preparation method and application thereof |
| CN108283649A (en) * | 2017-06-16 | 2018-07-17 | 湖南中和制药有限公司 | Three-dimensional cod-liver oil emulsion and its preparation process |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2202726A (en) * | 1987-04-02 | 1988-10-05 | Peter Jowett | Vitamin supplement |
| US4803087A (en) * | 1987-07-21 | 1989-02-07 | Ppg Industries, Inc. | Composition and method for producing vitamin-enriched milk |
-
1994
- 1994-11-30 CN CN94113650A patent/CN1048868C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2202726A (en) * | 1987-04-02 | 1988-10-05 | Peter Jowett | Vitamin supplement |
| US4803087A (en) * | 1987-07-21 | 1989-02-07 | Ppg Industries, Inc. | Composition and method for producing vitamin-enriched milk |
Non-Patent Citations (1)
| Title |
|---|
| 药剂辅料大全 1993.3.1 罗明生，高天惠 * |
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| Publication number | Publication date |
|---|---|
| CN1116925A (en) | 1996-02-21 |
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