CN104886574B - A kind of middle-aged and old health food for improving the health care of sleep protection eyesight and preparation method thereof - Google Patents
A kind of middle-aged and old health food for improving the health care of sleep protection eyesight and preparation method thereof Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention belongs to food technology field, and in particular to a kind of middle-aged and old health food for improving the health care of sleep protection eyesight and preparation method thereof.The formula for improving the health care of sleep the middle-aged and old health food for protecting eyesight of the present invention and proportioning are：Lutein 5% 10%, Black Ganoderma extract 20% 50%, epiphysin 1% 5%, Rhizoma Acori Graminei extract 20% 50%; present invention collocation is scientific and reasonable; can set aside all worries and calm the nerves, alleviate anxiety, promote sleep, improve the health care of sleep quality; and without phenomenons such as dizzy, the drowsiness, habituation produced by common drug after waking up; visual fatigue, the hypopsia because insomnia causes can also be alleviated simultaneously, improve eye-blurred, protection eyesight.
Description
Technical field
The invention belongs to food technology field, and in particular to it is a kind of improve the health care of sleep protection eyesight middle-aged and old health food and
Its preparation method.
Technical background
Sleep shows as body movement activity stopping, of flaccid muscles, consciousness and disappears, shuts off oneself from society；Metabolism declines, and permits
Perhaps the basic vital movement of body is ensured under conditions of energy ezpenditure minimum；Sensory perception and environment separation simultaneously lose respond
A kind of reversible state, often can " moment " complete sleep and awakening conversion.Sleep is a kind of active process, is to recover essence
Rest necessary to power, there is special maincenter management of sleep and awakening, and human brain is to have changed a kind of working method when sleeping, and makes energy
Stored, be conducive to the recovery of spirit and muscle power；It is both to maintain health and muscle power and appropriate sleep is best rest
Basis, is also the guarantee for obtaining height productivity.The time that all one's life of one people has 1/3rd is spent in sleep, sleeps
Dormancy is the guarantee in people's life-span, does not just have lived continuity without sleep, is restored by the spiritual muscle power of the people that sleeps, and human body is also
It is that necessary Physiological effect is carried out in sleep procedure.The elderly is reduced due to nerve cell, and sleep-disorder can be caused naturally,
Insomnia is exactly most common symptom.Into old age, the disease incidence of general increases, and cardiovascular and cerebrovascular disease is suffered from the elderly more
Disease, respiratory disease, and other degeneration spondylodynias, cervical spondylopathy, rheumatoid arthritis, numb limb etc., these diseases,
Sleep can in itself or with symptom be influenceed because of disease, the insomnia of the elderly is aggravated.Insomnia simultaneously also can influence body just
Normal metabolic function, induces various diseases, such as heart disease, ephrosis, asthma, canker, arthritis, osteoarthropathy, enterogastritis, blood high
Pressure, sleep apnea syndrome, hyperthyroidism, night flesh battle array spasm syndrome, cerebral disease etc., chronic insomnia can also
Accelerate aging, induce the emotional dysfunctions such as depression and anxiety.While insomnia toward contact can along with eyesight decline, at present
Sleeping product on the market, often unitary function, can only improve insomnia and can not improve visual fatigue, eye-blurred that insomnia brings
The problems such as.
The content of the invention
The present invention is possible to promote sleep and protects eyesight to solve the problems, such as that sleeping product function is single on the market
Functional component has carried out scientific and reasonable collocation, there is provided a kind of middle-aged and old health food for improving the health care of sleep protection eyesight.
The raw material group for protecting the middle-aged and old health food formula of eyesight by following parts by weight that improves the health care of sleep of the present invention
Into：Lutein 5%-10% parts, 20%-50% parts of Black Ganoderma extract, epiphysin 1%-5% parts, Rhizoma Acori Graminei extract 20%-
50% part.
Epiphysin used of the invention is provided by Shaanxi Sen Fu natural products Co., Ltd, food grade materials, containing amount≤99%.
Preparation method of the invention is mainly included the following steps that：
(1) preparation of lutein
Dried marigold flower pellets were crushed into 40 mesh sieves, a certain amount of marigold flower powder was weighed, by solid-liquid ratio 1:20 add
Extractant n-hexane, supercritical extraction process parameter is extracting pressure 20-25MPa, 50-60 DEG C of temperature, CO2Flow 10-12L/
H, extraction time 3-4h, to separate 40-50 DEG C of I temperature, pressure 10-15MPa separates 30-40 DEG C of II temperature, pressure to separation parameter
10-15MPa, extract solution heating in vacuum makes solvent volatilize, and obtains medicinal extract shape lutein ester, and lutein ester is added into ethanol solution
Middle dissolving, heating, is slowly added to NaOH solution, and stirs while hot, saponification 6-10h, is stirred to distilled water is added in mixed solution
Uniformly, supernatant is centrifuged off, sediment obtains lutein semifinished product through vacuum freeze drying, and semifinished product is molten with ethyl acetate
Solution, and unnecessary saponified and water-solubility impurity is washed off with deionized water, by ethyl acetate phase vacuum distillation recovered solvent,
To 4 times of n-hexane-acetone mixed solvents of volume are added in concentrate, (volume ratio is 4:1) mistake after 30min, is stood at room temperature
Filter, respectively with absolute ethyl alcohol and distillation water washing, vacuum freeze drying is obtained lutein crystal；
(2) preparation of Black Ganoderma extract
Black Ganoderma is purchased from Jinzhai County along Baokang eco-agricultural development Co., Ltd.
60 DEG C of the Black Ganoderma of purchase dry, pulverize, cross the Black Ganoderma of 40 mesh sieves → weigh after a certain amount of crushing → by
Solid-liquid ratio 1:15 addition distilled water → microwave abstracting 30 minutes → extract solution suction filtrations remove residue → be concentrated in vacuo to medicinal extract shape → cold
It is lyophilized it is dry → crushed 60 mesh sieves, it is standby；
(3) prepared by Rhizoma Acori Graminei extract
Grass-leaved sweetflag is purchased from Jinzhai County natural ecological Chinese medicine crop cultivation speciality cooperative society.
60 DEG C of the grass-leaved sweetflag drying that will be bought, crushes, and crosses the grass-leaved sweetflag of 40 mesh sieves → weigh after a certain amount of crushing → by material
Liquor ratio 1:20 add distilled water → 70 DEG C to extract 2 hours → filtering → repetition extracts 3 times, merging filtrate → be concentrated in vacuo to medicinal extract
Shape → freeze-drying → crushed 60 mesh sieves, it is standby；
(4) mix
Extracted by lutein 5%-10% parts, 20%-50% parts of Black Ganoderma extract, epiphysin 1%-5% parts, grass-leaved sweetflag
Thing 20%-50% parts of ratio of weight and number weighs lutein, Black Ganoderma extract, epiphysin, Rhizoma Acori Graminei extract, and mixing is equal
It is even；
(5) dispense
Each component is well mixed, soft capsule is distributed into,.
The Main Function of inventive formulation composition is：
Lutein：Lutein contains a large amount with the primary pigments that luteole is human eye retina's macular region, human eye
Lutein, and this pigment human body can not synthesize, can only be from external world's intake supplement.It can protect the eyes from phototoxis,
Delay the aging of eyes and prevent lesion, such as the ultraviolet and blue light in sunshine can produce substantial amounts of freedom into eyes
Base, causes cataract, macular degeneration, or even induces cancer, and the lutein in macula lutea can just filter out blue light, it is to avoid blue light is to eye
The infringement of eyeball.In addition, lutein can promote the regeneration of visual purple in retina cell as antioxidant and photoprotection agent
Into laser high myopia and detached retina can be prevented, and eyesight, protection eyesight can be promoted.Lutein can also suppress various ophthalmology
The generation of disease, such as senile retinal macular degeneration, cataract, conjunctivitis, photophobia.Lutein can also improve blood vessel and support
Drag, reduces vascular permeability, suppresses leaking material in blood vessel, it is ensured that the integrality of ocular vascular, allows eyes to obtain abundance
Blood supply.
Black Ganoderma：Ganoderma lucidum is Basidiomycetes, Polyporaceae, Ganoderma fungi, and main component is triterpenes, total saposins, total
Polysaccharide and peptides, its primary pharmacological activity shows as antitumor, enhancing and regulation immunologic function, anti-aging, anti-atherogenic are hard
The aspects such as change.Black Ganoderma is the superfine product in ganoderma lucidum, has medicinal curative effect to body-care, far above other kinds of ganoderma lucidum, energy
Enhancing body's immunity, long-term consumption can adjust internal various functions.Ganoderma lucidum Central nervous system is in inhibitory action, therefore mesh
Preceding ganoderma lucidum is also used for treatment nervous breakdown and consumptive disease insomnia.
Epiphysin：One kind nerve of epiphysin also known as melatonin, epiphysin, mainly mammal pineal body secretion
Hormone.The pharmacology and physiological action of epiphysin are quite varied, Main Function be regulation circadian rhythm, remove free radical, anti-inflammatory,
Anti-apoptotic, body-temp. reducing, suppression tumour growth, the reproductive system function that suppresses, raising memory, treatment dementia, anti-aging, anti-Jiao
Consider, improve osteoporosis, anti-epileptic etc..In eye, epiphysin participates in the change of regulation retinal function daily rhythmicity, retina
Information transmission etc..The epiphysin of human body in cradle night horizontal highest, from children to the level of adolescence epiphysin
It is average to reduce by 80%, low-level is maintained later, further reduced later by 50 years old.It is demonstrated experimentally that the epiphysin of very little dosage
Internal melatonin levels can be just made to reach normal and guide and fall asleep, and epiphysin all can be constantly produced daily in human body
A kind of hormone, so it simply is supplemented into normal level when it is lacked now, it is possible to recover normal physiologic sleep.
Grass-leaved sweetflag：Grass-leaved sweetflag is the dry rhizome of Araeceae herbaceos perennial grass-leaved sweetflag, first recorded in《The grass of the legendary god of farming hundred
Through》, top grade is listed in, taste is pungent is warm in nature, the gas for having fragrance, and the scattered power of row is strong, is the sensible good merchantable brand of a surname's gas, can remove dampness by means of aromatics,
Activating spleen and strengthening stomach, can change turbid eliminating the phlegm, have one's ideas straightened out and allay excitement again, be the key medicine of waking up the patient from unconsciousness by clearing away phlegm.Modern pharmacological research shows that grass-leaved sweetflag mainly contains
There are the chemical compositions such as volatile oil, amino acid, carbohydrate, aliphatic acid, inorganic elements, with medicines such as immune, antibacterial, anticancer, anti-mutation
Reason is acted on, and Central nervous system, cardio-cerebrovascular, respiratory system, digestive system etc. have certain pharmacological activity, clinical
On be widely used in the diseases such as epilepsy, convulsions, pyreticosis coma, forgetful, senile dementia, be encephalopathic good medicine few in number.
Calm the nerves the beneficial effects of the invention are as follows that can set aside all worries, alleviate anxiety, promote sleep, improve the health care of sleep quality, and
Without phenomenons such as dizzy, the drowsiness, habituation produced by conventional hypnotic after waking up.On the basis of good improving the health care of sleep, eyesight is protected,
Delay eyes aging, improve eye-blurred, alleviate visual fatigue.
Brief description of the drawings
Fig. 1 acute oral toxicity tests Mouse Weight increases
A1, a2, a3 are respectively the original body mass of control group mice, 1 weekend body weight, 2 weekend body weight, and b1, b2, b3 are experiment
Original body mass, 1 weekend body weight, the 2 weekend body weight of group mouse.
30 days feeding trial hematological results of Fig. 2
Project A is Erythrocytes (1012/ L), project B be hemoglobin sum (g10-1/ L), project C be leucocyte
Sum (109/ L), project D be total number of blood platelet (1011/L)；A is control group, and b is tested group of low dosage, and c is that middle dosage is tested
Group, d is tested group of high dose.
30 days feeding trial latter stage biochemical analysis results of Fig. 3
Project A is glutamic-pyruvic transaminase (U/L), project B is triglycerides (mmol/L), project C is creatinine (μm ol/L), item
Mesh D is blood sugar (mmol/L)；A is control group, and b is tested group of low dosage, and c is tested group of middle dosage, and d is tested group of high dose.
30 days feeding trial latter stage biochemical analysis results of Fig. 4
Project A is cholesterol (mmmol/L), project B is triglycerides (mmmol/L), project C is creatinine (μm ol/L),
Blood sugar (mmol/L)；A is control group, and b is tested group of low dosage, and c is tested group of middle dosage, and d is tested group of high dose.
Influence of the 30 days feeding trials of Fig. 5 to the dirty body ratio of rat
A is control group, and b is tested group of low dosage, and c is tested group of middle dosage, tested group of d high doses.
Specific embodiment
Case study on implementation 1 improves the health care of sleep person in middle and old age's functional food formula and preparation method of protection eyesight
The formula structure for protecting person in middle and old age's functional food formula of eyesight by following parts by weight that improves the health care of sleep of the present invention
Into：Lutein 5%-10%, Black Ganoderma extract 20%-50%, epiphysin 1%-5%, Rhizoma Acori Graminei extract 20%-50%.
Epiphysin used of the invention is provided by Shaanxi Sen Fu natural products Co., Ltd, food grade materials, containing amount≤99%.
Preparation method of the invention is comprised the following steps：
(1) preparation of lutein
Dried marigold flower pellets were crushed into 40 mesh sieves, a certain amount of marigold flower powder was weighed, by solid-liquid ratio 1:20 add
Extractant n-hexane, supercritical extraction process parameter is extracting pressure 20-25MPa, 50-60 DEG C of temperature, CO2Flow 10-12L/
H, extraction time 3-4h, to separate 40-50 DEG C of I temperature, pressure 10-15MPa separates 30-40 DEG C of II temperature, pressure to separation parameter
10-15MPa, extract solution heating in vacuum makes solvent volatilize, and obtains medicinal extract shape lutein ester, and lutein ester is added into ethanol solution
Middle dissolving, heating, is slowly added to NaOH solution, and stirs while hot, saponification 6-10h, is stirred to distilled water is added in mixed solution
Uniformly, supernatant is centrifuged off, sediment obtains lutein semifinished product through vacuum freeze drying.Semifinished product is molten with ethyl acetate
Solution, and unnecessary saponified and water-solubility impurity is washed off with deionized water, by ethyl acetate phase vacuum distillation recovered solvent,
To 4 times of n-hexane-acetone mixed solvents of volume are added in concentrate, (volume ratio is 4:1) mistake after 30min, is stood at room temperature
Filter, respectively with absolute ethyl alcohol and distillation water washing, vacuum freeze drying is obtained lutein crystal；
(2) preparation of Black Ganoderma extract
60 DEG C of the Black Ganoderma of purchase dry, pulverize, cross the Black Ganoderma of 40 mesh sieves → weigh after a certain amount of crushing → by
Solid-liquid ratio 1:15 addition distilled water → microwave abstracting 30 minutes → extract solution suction filtrations remove residue → be concentrated in vacuo to medicinal extract shape → cold
It is lyophilized it is dry → crushed 60 mesh sieves；
(3) prepared by Rhizoma Acori Graminei extract
60 DEG C of the grass-leaved sweetflag drying that will be bought, crushes, and crosses the grass-leaved sweetflag of 40 mesh sieves → weigh after a certain amount of crushing → by material
Liquor ratio 1:20 add distilled water → 70 DEG C to extract 2 hours, filtering → repeat to extract 3 times, merging filtrate → be concentrated in vacuo to medicinal extract
Shape → freeze-drying → crushed 60 mesh sieves, it is standby；
(4) mix
Extracted by lutein 5%-10% parts, 20%-50% parts of Black Ganoderma extract, epiphysin 1%-5% parts, grass-leaved sweetflag
Thing 20%-50% parts of ratio of weight and number weighs lutein, epiphysin, Black Ganoderma extract, Rhizoma Acori Graminei extract, and mixing is equal
It is even.
(5) dispense
By well mixed formula, capsule is distributed into,.
The toxicology test of case study on implementation 2
According to《Toxicological evaluation of food safety procedure and method》GB15193-2003, enters to functional food of the invention
Row Toxicological evaluation.
First, test method
1st, acute oral toxicity test：Tested using maximum tolerated dose, be the Kunming mouse of 18-22g from body weight
40, male and female half and half are randomly divided into female control group, female experimental group, male control group, male experimental group by sex.With this
Invent the functional food 25g for preparing and add distilled water to 60mL (up to mouse maximum gavage concentration), give experimental mice gavage, daily
Gavage intergal dose 25g/kgbw twice, the distilled water of control group gavage equal volume, Continuous Observation two weeks after gavage, record
Poisoning manifestations and death condition.
2nd, 30 days feeding trials：From SD rats 40, male and female half and half, raettin body weight 73.8 ± 5.6, male mouse body weight 70.9
± 8.4, it is randomly divided into four groups, i.e. control group and three tested group, every group 10, male and female half and half, with function prepared by the present invention
Food basic, normal, high dosage 1.0g/kgbw, 2.0g/kgbw, 3.0g/kgbw be respectively equivalent to human body amount 50,
75th, 100 times, 1.5mL/100gbw volume gavages are pressed to rat, control group with isometric distilled water, once a day, continuously
Feed 30 days.
2nd, result of the test
1st, acute oral toxicity experimental result
A1, a2, a3 are respectively the original body mass of control group mice, 1 weekend body weight, 2 weekend body weight, b1, b2, b3 in Fig. 1
It is original body mass, 1 weekend body weight, the 2 weekend body weight of experimental mice.
Acute oral result of the test shows：
(1) two kinds of kunming mice gavages of sex, are given not with the functional food of the present invention preparation of 25g/kgbw dosage
See obvious poisoning symptom；
(2), as shown in Figure 1, Mouse Weight increases normal during observation, the no significant difference (p compared with control group>
0.05), and without death condition；
(3), the observation period terminate after gross anatomy observation is done to mouse liver, kidney, lungs, spleen etc., no abnormality seen changes
Become, two kinds of Oral toxicity maximum tolerated doses (MTD) of sex mouse are more than 25.0g/kgbw, according to《Health food is checked
With assessment technique specification》Acute toxicity grading criteria in (2003 editions), belongs to nontoxic level.
2nd, 30 days feeding trial results
(1) mouse blood inspection result after, feeding for 30 days
Project A is Erythrocytes (10 in figure12/ L), project B be hemoglobin sum (g10-1/ L), project C be white
TCS (109/ L), project D be total number of blood platelet (1011/L)；A is control group, and b is tested group of low dosage, and c is middle dosage
Tested group, d is tested group of high dose, and with mean value calculation, as shown in Figure 2, nursing in 30 days terminates observation item, basic, normal, high by three
The hematological results of individual dosage group mouse no significant difference (p compared with control group>0.05).
(2), feed within 30 days and terminate mouse biochemical analysis result
In Fig. 3, project A is glutamic-pyruvic transaminase (U/L), project B is triglycerides (mmol/L), project C is creatinine (μ
Mol/L), project D is blood sugar (mmol/L)；A is control group, and b is tested group of low dosage, and c is tested group of middle dosage, and d is agent high
Tested group is measured, each inspection project is with mean value calculation, from the figure 3, it may be seen that feeding within 30 days the biochemical inspection for terminating rear each dose of test group
Come to an end fruit no significant difference (p compared with control group>0.05).
In Fig. 4, project A is cholesterol (mmmol/L), project B is triglycerides (mmmol/L), project C is creatinine (μ
Mol/L), blood sugar (mmol/L)；A is control group, and b is tested group of low dosage, and c is tested group of middle dosage, and d is that high dose is tested
Group, as shown in Figure 4, feeds after terminating, the 3 biochemical analysis result of tested group of mouse no significant differences compared with control group for 30 days
(p>0.05)。
(3), feed within 30 days and terminate dirty body ratio result
During 30 days feed, each group rat growthing development is good, behavior without exception and poisoning symptom, without death, liver,
Spleen, kidney, duodenum, testis (ovary) tissue pathology checking without substantially infringement, the blood routine of each group rat, blood bio-chemistry checking with
And dirty body ratio result such as Fig. 5.
A is control group in figure, and b is tested group of low dosage, and c is tested group of middle dosage, tested group of d high doses, each check item
Mesh is with mean value calculation, as shown in Figure 5, dirty body ratio no significant difference (p compared with control group of each dosage group mouse>
0.05)。
The Evaluation of Functional of case study on implementation 3 is tested
To prove effect of the invention, according to《Health food is checked and assessment technique specification》(2003 editions) have carried out function
Property evaluation test.
2 crowd's observation experiments
2.1 experimental subjects：
Experiment point 50-60 Sui, 60-70 Sui, 70-80 Sui three groups, every group of selection has sleep-disorder and with visual fatigue eyesight
The fuzzy people of patient 120, experimental group and control group are randomly divided into according to the weight of symptom.
2.2 test methods：
Using 2 kinds of control modes between itself and group, by a kind of above-mentioned middle-aged and old health food for improving the health care of sleep protection eyesight
The food for preparing is formulated, is taken to experimental group, once a day, 2 every time, control group takes placebo, continuously takes 60 days.It is real
Test start and at the end of understand subject's sleep and eyesight status with sleep state self-appraisal table and eyesight status application form
Front and rear change, counts symptom total mark, according to《Health food is checked and assessment technique specification》The evaluation criterion of (2003 editions) is entered
Row effect judge.
2.3 effect assessments：
++：Represent that eyesight and sleep state are significantly improved；
+：Represent that eyesight and sleep state have preferably improvement；
-：Eyesight and sleep state are represented substantially without improvement, or even has worse trend.
2.4 observation results
The 50-60 Sui group of table 1 improves result
The 60-70 Sui group of table 2 improves result
The 70-80 Sui group of table 3 improves result
From table 1,2,3, experimental group has highly significant (p with control group difference<0.01), illustrate that the present invention can be with
Improve the health care of sleep well, and alleviate visual fatigue and eye-blurred.
3 conclusions
By function above evaluation test, it was demonstrated that the present invention can be very good improve insomnia, while alleviate visual fatigue and
Eye-blurred.The present invention can also set aside all worries in preparation and calm the nerves, promotes to be applied in sleep, the health food of protection eyesight.
Claims (1)
1. it is a kind of improve the health care of sleep protection eyesight person in middle and old age's food preparation method, it is characterized in that being made up of following steps：
(1) raw material weight proportioning of soup processed
Lutein 5%-10%, Black Ganoderma extract 20%-50%, epiphysin 1%-5%, Rhizoma Acori Graminei extract 20%-50%；
(2) preparation of lutein
Dried marigold flower pellets were crushed into 40 mesh sieves, a certain amount of marigold flower powder was weighed, by solid-liquid ratio 1:20 add extraction
Agent n-hexane, supercritical extraction process parameter is extracting pressure 20-25MPa, 50-60 DEG C of temperature, CO2Flow 10-12L/h, extraction
Time 3-4h is taken, to separate 40-50 DEG C of I temperature, pressure 10-15MPa separates 30-40 DEG C of II temperature, pressure 10- to separation parameter
15MPa, extract solution heating in vacuum makes solvent volatilize, and obtains medicinal extract shape lutein ester；Lutein ester is added in ethanol solution
Dissolving, heating, is slowly added to NaOH solution, and stirs while hot, saponification 6-10h, and to being added in mixed solution, distilled water stirring is equal
It is even, supernatant is centrifuged off, sediment obtains lutein semifinished product through vacuum freeze drying, and semifinished product ethyl acetate dissolves,
And unnecessary saponified and water-solubility impurity is washed off with deionized water, by ethyl acetate phase vacuum distillation recovered solvent, to
4 times of n-hexane-acetone mixed solvents of volume are added in concentrate, is filtered after 30min is stood at room temperature, absolute ethyl alcohol is used respectively
With distillation water washing, vacuum freeze drying is obtained lutein crystal；
(3) preparation of Black Ganoderma extract
60 DEG C of the Black Ganoderma of purchase dry, pulverize, the Black Ganoderma of 40 mesh sieves → weigh after a certain amount of crushing → by feed liquid is crossed
Than 1:15 addition distilled water → microwave abstracting 30 minutes → extract solution suction filtrations go residue → be concentrated in vacuo to medicinal extract shape → freezing dry
It is dry → to crush 60 mesh sieves, it is standby；
(4) prepared by Rhizoma Acori Graminei extract
60 DEG C of the grass-leaved sweetflag drying that will be bought, crushes, and crosses the grass-leaved sweetflag of 40 mesh sieves → weigh after a certain amount of crushing → by solid-liquid ratio
1:20 add distilled water → 70 DEG C to extract 2 hours → filtering → repeat to extract 3 times, and merging filtrate → be concentrated in vacuo to medicinal extract shape →
Freeze-drying → crushed 60 mesh sieves, it is standby；
(5) mix
Lutein, epiphysin, Black Ganoderma extract, Rhizoma Acori Graminei extract are weighed by step (1) described percentage by weight, mixing is equal
It is even；
(6) dispense
Each component is well mixed, soft capsule is distributed into,.
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