CN104874095A - Brain-targeted intranasal administration apparatus and body position fixing device thereof - Google Patents
Brain-targeted intranasal administration apparatus and body position fixing device thereof Download PDFInfo
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- CN104874095A CN104874095A CN201410072934.6A CN201410072934A CN104874095A CN 104874095 A CN104874095 A CN 104874095A CN 201410072934 A CN201410072934 A CN 201410072934A CN 104874095 A CN104874095 A CN 104874095A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61G—TRANSPORT, PERSONAL CONVEYANCES, OR ACCOMMODATION SPECIALLY ADAPTED FOR PATIENTS OR DISABLED PERSONS; OPERATING TABLES OR CHAIRS; CHAIRS FOR DENTISTRY; FUNERAL DEVICES
- A61G13/00—Operating tables; Auxiliary appliances therefor
- A61G13/10—Parts, details or accessories
- A61G13/12—Rests specially adapted therefor; Arrangements of patient-supporting surfaces
- A61G13/1205—Rests specially adapted therefor; Arrangements of patient-supporting surfaces for specific parts of the body
- A61G13/121—Head or neck
- A61G13/1215—Head or neck with patient airway positioning devices
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Abstract
The invention discloses a brain-targeted intranasal administration apparatus and a body position fixing device thereof. The brain-targeted intranasal administration apparatus comprises the body position fixing device and an administration device. The body position fixing device is used for keeping the body position of a user in a state that drugs administrated through a nasal cavity can enter a specific olfactory region in the upper nasal cavity. The administration end of the administration device has a shape matching the nasal cavity of the user. The administration device is used for administrating the drugs to the user under a condition that the body position fixing device keeps the user in the body position mentioned above, and the drugs are directed into the brain. Specifically, the body position fixing device comprises a head holder used for bearing the head of the user and keeping the head in a state that the drugs administrated through the nasal cavity can enter the olfactory region in the upper nasal cavity. The head holder comprises a headrest, supports and a middle axle rod, wherein the headrest is used for bearing the head of the user, and the headrest is rotatably supported on the supports through the middle axle rod. The user is kept in the specific administration body position, and the administration apparatus is controlled by intelligent elements, so that the drugs administrated through the nasal cavity can enter the olfactory region in the upper nasal cavity at a fixed time, with fixed speed, and with fixed quantify, and the drugs are targeted to the brain.
Description
Technical field
The present invention relates to a kind of doser, specifically, relate to a kind of technology of via intranasal application administration of Brain targeting.Usually be applicable to after nose administration, targeting acts on medicine and the preparation of brain, be particularly useful for that various medicine is sent to brain targeting and include but not limited to insulin and derivant thereof, in order to improve the clinical symptoms of Alzheimer and other central nervous system disease.
Background technology
When treating brain diseases as multiple sclerosis, parkinson disease, epilepsy, senile dementia, brain tumor and acquired immune deficiency syndrome (AIDS), medically there is a difficult problem always, that is: how blood brain barrier is overcome, medicine is entered in central nervous system (central nervous system, CNS) to play drug action.Applying more method clinically is at present open blood brain barrier by reversibility, and intrathecal injection and carotid injection administration, make agent permeates therethrough and enter CNS.But these methods require that in operating technology high, security risk is large, and application is subject to certain restriction.Based on the special construction of nasal cavity, by nasal-cavity administration treatment brain diseases have Noninvasive, brain bioavailability high, first passage metabolism and the advantage such as body circulation and blood brain barrier can be walked around, and handled easily.
Usually, after nasal-cavity administration, blood is entered after drug molecule (micromolecule, polypeptide hormone, protein bio preparation etc.) can be inhaled into pulmonary, or directly enter absorbed into serum after digestive system, but add nasal-cavity administration mode by appropriate device, these drug molecules also can be made to be accumulated in the regio olfactoria originating in the nervi olfactory extension of brain of nasal cavity.Have been reported the display medicine (micromolecule, polypeptide, protein) accumulated in regio olfactoria and directly can infiltrate through brain (see Arun et al., 2012), although this infiltration there is no based on iuntercellular intracellular transport clearly to come to a conclusion.In addition, in clinical studies, find many hormones, if thyroliberin (ACTH), vassopressin (Vasopressin), the concentration of insulin in cerebrospinal fluid are all higher than hormone endogenous concentration in blood, outside illustrating that these hormones play a role with the exception that in week, also may play different important function central nervous system.Such as, with regard to insulin, by specific nasal-cavity administration mode insulin accumulated in regio olfactoria, in 36 health volunteers, in average cerebrospinal fluid, insulin concentration is 2 times of endogenous insulin concentration, and in blood plasma, insulin concentration does not then have significant change (see table 1).The prompting of this result makes insulin accumulate in regio olfactoria when using appropriate method, and insulin can directly enter central nervous system (see Born et al., 2002) by this region.
Table 1: drug exposure (n=36) * of cerebrospinal fluid and serum after mankind's nasal-cavity administration
* 9 women and 27 are the nasal-cavity administration that male subject receives insulin or thyroliberin (melanocortin) respectively, and measure serum and cerebrospinal fluid (CSF) drug level.The exposed amount of medicine in central nervous system and blood circulation is evaluated by the area calculated under drug-time curve.Data come from Born et al., and 2002.
aincreasing multiple is ratio gained by calculating experimental group drug exposure and placebo group endogenous hormone exposed amount in different chamber (CSF or serum).
The various injections of insulin and derivant thereof have been widely used in the glycemic index controlling diabetic.Before more than ten years, once had report to find the temporary transient rising of insulin concentration in blood plasma, the rising along with insulin concentration in cerebrospinal fluid can strengthen the nonverbal memory (see Kern W et al., 2001) of Healthy People.In the test of healthy students, week for 7 weeks via intranasal application every day administration 160IU insulin, can improve Delay recall function.Talbot etc. recently research show because insulin resistant causes insulin-like growth factor-i in brain (IGF-1) path signal conductive obstruction, be Alzheimer (Alzheimer ' s Disease, AD) feature performance (see Talbot, K.J.Clin.Invest.2012:1316-1338) of brain lesions.In the disease that some function of nervous system are impaired, as in Alzheimer, research finds that 312,616 or 636 serine residues (IRS-1pSer312, the 616 or 636) phosphorylation under base state of brain insulin receptor 1 is a large feature of the brain insulin opposing of AD user.This discovery prompting is even in normal individual, and in brain, the actual demand of insulin is also considerably beyond normal physiological condition.
Table 2 enumerates the evidence of some Brain targeting via intranasal application insulin administrations for neurological and neuroethology therapeutic effect.These data sufficient proof, by a kind of appropriate, simple nasal cavity insulin administration methods that effectively can improve cerebrospinal fluidconcentration, can produce far-reaching influence to neurobehavioral, and can not change body circulating plasma insulin concentration.Up to now, per nasal gives 160IU insulin can not produce any toxic and side effects to nasal cavity and regio olfactoria, also can not trigger insulin in the side effect of peripheral-system or other neural untoward reaction.Therefore, Brain targeting per nasal insulin administration can be considered to the safe and effective method for the treatment of, improving function of nervous system's compromised condition.
Table 2: insulin Brain targeting nose administration is for the impact of neurobehavioral disease and symptom thereof
adata from Benedict et al., 2004, Psychoneuroendocrinology
bdata from Reger et al., 2008, J Alzheimer ' s Disease13,323
Although about the neurobehavioral function of Alzheimer precise mechanism and imperfectly understand, what was certain was that increase the prodrome that the insulin level of central nervous system can have influence on the cognition of Alzheimer adult user, imaging and biochemical parameter and this disease, i.e. mild cognition impairment (MCI).There is experiment to prove directly to be introduced by insulin the central nervous system of Alzheimer animal model, its nerve injury can be improved.In some clinical trials, the administration of insulin intranasal chamber is introduced brain by the verified mode by complexity, can improve the mild cognition impairment of user.In sum, promote the insulin level in brain and central nervous system, will the neurobehavioral function improving user be contributed to.Therefore, need a kind of device and method of Brain targeting nasal-cavity administration of can being in separately by patient self or home care personnel badly, this device or method need simple to operate, easy left-hand seat, this kind of administering mode in the past can being overcome and need the instrument of complex and expensive and the medical personnel's just operable shortcoming through strict professional training, making user just easily can complete daily administration work without the need to going to hospital.
Summary of the invention
Brain targeting drug delivery system is a very active research field in pharmacy and the relevant medical domain such as neuropathy, tumor, and for the purpose of Brain targeting, via intranasal application drug-supplying system is then a study hotspot in recent years.And the via intranasal application administration of Brain targeting, need to make drug accumulation in upper nasal cavity by certain method, i.e. regio olfactoria, to avoid being absorbed into body circulation through respiratory tract and digestive tract, thus directly enter central nervous system.For this reason, the invention provides a kind of via intranasal application doser and body position fixture thereof of Brain targeting, the medicine of via intranasal application administration is enable to enter the regio olfactoria of upper nasal cavity in conjunction with specific administration position, and targeting acts on brain, the Brain targeting nose administration system of complexity is simplified by it, enable user in person or by assistance such as family members, home care personnel, just can complete operation in home environment, and reach the object of timing, constant speed, quantitatively brain-targeted drug delivery.The via intranasal application doser of Brain targeting provided by the invention and body position fixture thereof are also applicable to field emergency, as under battlefield surroundings, when time, medical apparatus and instruments, medical worker's deficiency, can carry out simply with device provided by the invention, brain-targeted drug delivery rapidly, as the symptom etc. for alleviating central nervous system.
On the one hand, the invention provides a kind of body position fixture of the via intranasal application administration for Brain targeting, this body position fixture comprises:
Head supporting part, for carrying the head of user and enabling head be held in make the medicine of via intranasal application administration enter the regio olfactoria of upper nasal cavity.
Wherein, described head supporting part comprises: for carry the head of user headrest, for support described headrest bracing frame and for described headrest being rotatably supported on the central shaft rod on support frame as described above.
In one embodiment of the invention, described headrest comprises: internal stent, is supported in described central shaft rod; Bolster, is covered in or is coated in described internal stent.
Further, described headrest is divided into Part I and Part II; Wherein, Part I is arranged to become the angle of 50 ° to 70 ° to support by a part for described internal stent, is preferably 60 °; And/or described Part II is arranged to become the angle of 20 ° to 40 ° to support by another part of described internal stent, be preferably 30 °.
In another embodiment of the invention, described headrest comprises: have the first surface for dorsal position administration and the two-sided bolster of second for lateral position administration.
Wherein, described first surface comprises cervical region loading end and carrier of head face, and described carrier of head face becomes human body incidence curve when lying on the back of fitting respectively with the profile design of cervical region loading end.Described second face also comprises cervical region loading end and carrier of head face, and described carrier of head face becomes human body incidence curve when lying on one's side of fitting respectively with the profile design of cervical region loading end.
In the various embodiments of the present invention, described bolster can be the bolster of portable, inflatable bolster or other implants.
In other embodiments of the present invention, support frame as described above is roughly H-shaped, A shape, L shape, Y shape, M shape or other exercisable shapes.
Described central shaft rod is horizontal through the Part I of described headrest and the central authorities of Part II interface, or, laterally through the cervical region loading end end of the two-sided bolster of described headrest.
In the embodiment that the present invention is other, described head supporting part also comprises:
Height regulating mechanism, for adjusting described central shaft rod and the headrest that the connects height on support frame as described above thereof to adjust the height of described headrest.
In the embodiment that the present invention is other, described body position fixture also comprises:
First mechanical arm, operatively engages with described head supporting part, for the angle of headrest adjusting central shaft rod and connect.
In the embodiment that the present invention is other, described body position fixture also comprises:
Motor, operatively engages with described head supporting part, for adjusting the angle of described headrest under the control of computer, smart mobile phone or remote controller.
In the embodiment that the present invention is other, described body position fixture also comprises: division indicator, this division indicator accurately detects the nose of user by laser beam, the elevation angle of collar indicates user head to be adjusted to administration angle that is suitable or the best, so that individual administration.
In the embodiment that the present invention is other, described body position fixture also comprises:
Audio player, for playing the audio file instructing user to regulate position; And/or
Video player, for playing the video file instructing user to regulate position.
In the embodiment that the present invention is various, described body position fixture also comprises: the platform supporting described head supporting part and user health, such as, includes but not limited to: mat, bed, chair, desk, sales counter, floor and other similar supporting plane.Wherein, described platform can carry out angular adjustment in order to the loading end carrying user health, to coordinate the angle of described headrest, make user keep more comfortable per nasal brain-targeted drug delivery position.
On the other hand, present invention also offers a kind of via intranasal application doser of Brain targeting, wherein said device comprises:
According to the body position fixture in above-mentioned various embodiment described in any one embodiment, for the position of user being held in the regio olfactoria enabling the medicine of via intranasal application administration enter specific upper nasal cavity; With
Administrator, its administration end has the shape coordinated with the nasal cavity of user, to user administration, makes medicine orientation enter brain for the via intranasal application when user is held in above-mentioned position by described body position fixture.
In other embodiments of the present invention, the via intranasal application doser of described Brain targeting also comprises:
Second mechanical arm, its one end is connected with described administrator, and described second mechanical arm is configured to regulate to be supported in place by described administrator.Wherein, the other end of described second mechanical arm is connected with described body position fixture.
In further embodiment of the present invention, the via intranasal application doser of described Brain targeting also comprises:
Based Intelligent Control element, time of administration, speed and dosage is regulated for the action by controlling described administrator and the second mechanical arm, comprise reception, process, integrate the extraneous information inputted, automatically control, regulate the administration time of administrator, speed and dosage according to inputted information, wherein, the information of described input comprises the physical signs, biochemical indicator, cognitive function scoring etc. of user.
In other embodiment of the present invention, described administrator comprises medicament reservoir.Such as, described medicament reservoir can be good biocompatibility, aseptic and/or disposable container.Described medicament reservoir can be fixed volume container, or can quantitatively promote or the syringe of pressurizing unit for having.
The via intranasal application doser of a kind of Brain targeting described in the various embodiment of the present invention and body position fixture thereof, be mainly used in the drug treatment of central nervous system disease, include but not limited to that presenile dementia, brain tumor, multiple sclerosis, parkinson disease, epilepsy, acquired immune deficiency syndrome (AIDS), tuberculosis, brain are viral, bacillary, disease that parasite or other infected by microbes, pituitary-hypothalamic hormonoprivia or imbalance cause, and for alleviating the relevant symptom of central nervous system.
Adopt the body position fixture according to the various embodiment of the present invention and the doser with this body position fixture, can by patient self or home care personnel simple operations, such as by patient head to lie on the back or lateral position is placed in described body position fixture, the via intranasal application administration of Brain targeting can be realized.Adopt device provided by the invention, simple to operate, easy left-hand seat, overcoming this kind of administering mode in the past needs the instrument of complex and expensive and the medical personnel's just operable shortcoming through strict professional training, makes user easily can complete daily administration work.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, various advantage of the present invention, feature and various aspects thereof are described in detail, in all descriptions, adopt the parts that similar Reference numeral represents similar, wherein:
Fig. 1 shows the embodiment 1 of the head supporting part of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention, not shown bolster;
Fig. 2 shows the headrest according to embodiment 1, and wherein, in order to illustrate the inside of headrest, its bolster takes foreshortened figure;
Fig. 3 shows the internal structure of the headrest after according to the removing bolster of embodiment 1;
Fig. 4 shows the embodiment 2 of the head supporting part of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention, not shown bolster;
Fig. 5 shows the headrest according to embodiment 2, and wherein, in order to illustrate the inside of headrest, its bolster takes foreshortened figure;
Fig. 6 shows the internal structure of the headrest of the removing bolster according to embodiment 2;
Fig. 7 shows the internal structure of the headrest of the removing bolster according to embodiment 2, and wherein, central shaft rod is through the internal stent of headrest;
Fig. 8 shows the embodiment 3 of the head supporting part of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention;
Fig. 9 shows the embodiment 4 of the head supporting part of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention;
Figure 10 shows the embodiment 5 of the head supporting part of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention;
Figure 11 schematically shows the state that user head is in dorsal position;
Figure 12 schematically shows the state that user head is in lateral position;
Figure 13 shows the embodiment 6 of the head supporting part of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention;
Figure 14 shows user (Mygind) position of taking to lie on the back and carries out administration;
Figure 15 shows and adopts user (Regan) position of taking to lie on one's side to carry out administration;
Figure 16 shows the body position fixture be positioned on platform according to embodiment of the present invention;
Figure 17 is that when adopting embodiment of the present invention to carry out dorsal position administration, nasal cavity dissects diagram.
Detailed description of the invention
Be described in detail to various aspects of the present invention below in conjunction with the drawings and specific embodiments.Wherein, well-known device, processor, module and connection each other, control or operation do not illustrate or do not elaborate.Further, described feature, assembly, parts, element or function can combine by any way in one or more embodiments.It will be appreciated by those skilled in the art that following various embodiments are only for illustrating, but not for limiting the scope of the invention.It is also understood that module in each embodiment described herein and shown in the drawings or assembly, parts, element, unit or step can be undertaken combining and designing by various difference configuration.
Various embodiment according to the present invention describes a kind of via intranasal application doser with the Brain targeting of body position fixture herein, wherein, described body position fixture is suitable for promoting medicine to enter upper nasal cavity and being entered the position of brain further by regio olfactoria for being remained on by user.Wherein, the via intranasal application doser of described Brain targeting also comprises administrator, the administration end of this administrator has the shape coordinated with the nasal cavity of user, for the via intranasal application when user is held in above-mentioned position by described body position fixture to user administration, so that medicine orientation enters brain.Thus, achieve brain-targeted drug delivery, avoid medicine to enter respiratory tract or/and digestive tract and cause non-targeted administration and dosage inadequate.In the various embodiments of the present invention, described body position fixture comprises a supporting part, this supporting part is for carrying the head of user and head being held in the regio olfactoria enabling the medicine of via intranasal application administration enter upper nasal cavity, such as, user incidence kept specific angle to ensure that the medicine of via intranasal application administration can enter the regio olfactoria of specific upper nasal cavity regularly, quantitatively, to reach the object of accurate individuation brain-targeted drug delivery, this will hereafter specifically describe.
[embodiment 1]
Fig. 1 shows the head supporting part 100 of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention, wherein for the ease of illustrating the internal structure of a supporting part, and not shown bolster; Fig. 2 shows the headrest 110 being coated with bolster 112 in internal stent 111, and in the figure in order to illustrate the internal structure of headrest 110, its bolster 112 takes foreshortened figure, that is: can see that it is inner through bolster 112; Fig. 3 shows according to the removing of embodiment of the present invention or the internal structure removing the headrest 110 after bolster 112.In an exemplary embodiment of the present invention embodiment, described body position fixture is suitable for promoting medicine to enter upper nasal cavity and being entered the position of brain further by regio olfactoria for being remained on by user.Specifically, described body position fixture comprises the head for carrying user and head is held in the head supporting part 100 enabling the medicine of via intranasal application administration enter the regio olfactoria of upper nasal cavity, as shown in Figure 1, described head supporting part 100 includes, but are not limited to: for carry the head of user headrest 110, for the bracing frame 120 that supports headrest 110 and the central shaft rod 130 headrest 110 is rotatably supported on bracing frame 120.Wherein, in embodiments of the present invention, bracing frame 120 is two H-shaped supports, each H-shaped support is made up of the horizontal linking arm 122 of column described in two columns 121 and lateral connection vertically arranged, and two ends of central shaft rod 130 are supported in the "-" of horizontal linking arm 122(" H " centre of each H-shaped support respectively rotationally) on.It should be noted that, the present invention is not limited thereto, those skilled in the art, under the condition not departing from principle of the present invention, can modify to various embodiment or develop, such as, multiple H-shaped support can be adopted, meanwhile, other supporting constructions can also be adopted, such as, in A shape, L shape, the bracing frame of Y shape, M shape or other exercisable shapes of falling, will be specifically described below.
In embodiments of the present invention, as shown in Figure 2, headrest 110 comprises: internal stent 111, and it is supported in described central shaft rod 130; Bolster 112, it is covered in described internal stent 111, and such as, bolster 112 can be wrapped in described internal stent 111.As shown in Figure 3, described internal stent 111 comprises: diverse location vertically in central shaft rod 130, to stretch out the many support bars 113 arranged, the many long connecting rods 114 end cross of described many support bars 113 coupled together along the direction almost parallel with central shaft rod 130 and the short connecting rod 115 that coupled together the end of described many long connecting rods 114 from the radial surface of central shaft rod 130.Wherein, the described many short connecting rods 115 of described internal stent 111 end form approximate tetragons, thus make the end face of headrest 110 for roughly quadrangle form.Certainly, those skilled in the art are to be understood that, the present invention is not limited thereto, internal stent 111 can be the arbitrary structures being configured to be supported on by bolster 112 in central shaft rod 130, such as, internal stent can be made up of the connecting plate allowing central shaft rod form the surface of carrying bolster through polylith gripper shoe wherein and the end being connected described gripper shoe, and this will be described in more detail below.In addition, described bolster 112 can adopt any material meeting the human engineering of human body head and cervical region known in the art to form, and such as, described bolster can be the bolster of portable, inflatable bolster or other implants, to provide comfort level.
In embodiments of the present invention, headrest 110 is divided into Part I and Part II, as shown in Figure 2, Part I (namely, the roughly tetragon end face of resting the head in Fig. 2 become the part at the place, limit of 60 ° of angles with diagonal) be arranged to become the angle of 50 ° to 70 ° to support by a part for internal stent 111, such as, the angle of 50 ° is become to support by a part for internal stent 111, or become the angle of 70 ° to support by a part for internal stent 111, preferably, the angle of about 60 ° is become to support, so that the posture that user or user take health to lie on the back (i.e. dorsal position) carries out via intranasal application brain-targeted drug delivery, Part II (namely, the roughly tetragon end face of resting the head in Fig. 2 become the part at the place, limit of 30 ° of angles with diagonal) be arranged to become the angle of 20 ° to 40 ° to support by another part of internal stent 111, such as, the angle of 20 ° is become to support by another part of internal stent 111, or become the angle of 30 ° to support by another part of internal stent 111, preferably, the angle of about 30 ° is become to support, so that user or user take the posture (i.e. lateral position) of lying on one's side to carry out via intranasal application brain-targeted drug delivery.Wherein, central shaft rod 130 is laterally through the Part I of described headrest and the central authorities of Part II interface, by making headrest 110 rotate optionally to use described Part I and Part II around central shaft rod 130, and then select to take different positions to carry out via intranasal application brain-targeted drug delivery.Such as, can by the angle of headrest 110 adjusting central shaft rod 130 and be connected with the mechanical arm (not shown) that head supporting part 100 operatively engages.As selection, the motor (not shown) operatively engaged with described head supporting part can be adopted, such as small-sized or micromachine, for adjusting the angle of described headrest under the control of computer, smart mobile phone or remote controller, thus, accurately control the position of user to make the medicine of via intranasal application administration be absorbed into brain best.
[embodiment 2]
Fig. 4 shows the head supporting part 200 of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention, wherein, for the ease of illustrating the internal structure of a supporting part 200, and not shown bolster; Fig. 5 shows the headrest 210 being coated with bolster 212 in internal stent 211, and in the figure in order to illustrate the inside of headrest 210, its bolster 212 takes foreshortened figure, that is: can see that it is inner through bolster 212; Fig. 6 shows the internal structure of the headrest 210 removing bolster 212 according to embodiment of the present invention, the figure shows and passes internal stent 211 so that support internal stent 211 according to embodiment of the present invention central shaft rod 230.It should be noted that; each embodiment of the present embodiment and the embodiment of embodiment 1 similar; those skilled in the art are to be understood that; whole feature of the various embodiments described in embodiment 1 or Partial Feature can be combined or be merged in the present embodiment 2 with the present embodiment 2; and described combination or merge formed embodiment also as embodiments of the present invention, and fall into claim of the present invention limit protection domain within.
In an exemplary embodiment of the present invention embodiment, described body position fixture is suitable for promoting medicine to enter upper nasal cavity and being entered the position of brain further by regio olfactoria for being remained on by user.Specifically, described body position fixture comprises the head for carrying user and head is held in makes the medicine of via intranasal application administration enter the head supporting part 200 of the regio olfactoria of upper nasal cavity, as shown in Figure 4, described head supporting part 200 includes, but are not limited to: for carry the head of user headrest 210, for the bracing frame 220 that supports described headrest 210 and the central shaft rod 230 described headrest 210 is rotatably supported on support frame as described above 220.Wherein, in embodiments of the present invention, bracing frame 220 is the support of two approximate A shapes, each A-bracket is made up of two oblique columns 221 and horizontal linking arm 222, wherein the upper end of two oblique columns 221 links together, lower end separately, is linked together by horizontal linking arm 222 between upper and lower two ends; Two ends of central shaft rod 230 support in the "-" of horizontal linking arm 222(" A " centre of corresponding A-bracket respectively rotationally) on.It will be appreciated by those skilled in the art that the present invention is not limited thereto, other supporting constructions known in the art can be adopted, such as, L-shaped, fall the bracing frame of Y shape, M shape or other exercisable shapes, such as, above-mentioned H-shaped support.
In embodiments of the present invention, as shown in Figure 5, headrest 210 comprises: internal stent 211, is supported in described central shaft rod 230; Bolster 212, is covered in described internal stent 211.As shown in Figures 6 and 7, internal stent 211 comprises at least two gripper shoes 213 and the many connecting rods 214 being connected gripper shoe, wherein, described gripper shoe 213 is arranged at the two ends of internal stent 211 at least respectively, gripper shoe 213 is roughly tetragon, and, as shown in Figure 6, two limits separately, a pair diagonal angle in two pairs of diagonal angles of this tetragon are configured to: limit be connected this diagonal to diagonal angle and become 60 °, another limit becomes 30 ° with described diagonal, thus headrest 210 is divided into Part I (namely becoming the part at the place, limit of 60 ° of angles with diagonal) and Part II (namely becoming the part at the place, limit of 30 ° of angles with described diagonal).Gripper shoe 213 has hole 215 at above-mentioned cornerwise middle section, and as shown in Figure 7, central shaft rod 230 is passed hole 215 and is connected with described gripper shoe 213, thus is supported on rotationally on bracing frame 220 by headrest 210.Different gripper shoes 213 couples together to form internal stent 211 at four angles of the gripper shoe 213 of tetragon or segment angle place by described many connecting rods 214 respectively, and described many connecting rods 214 are for Support cover bolster 212 thereon.
Certainly, those skilled in the art are to be understood that, the present invention is not limited thereto, gripper shoe 213 is not limited to tetragon, can be other any shapes, simultaneously, also connecting plate can be adopted to substitute many connecting rods 214, such as, adopt the four edges of the corresponding gripper shoe 213 of four pieces of connecting plates different gripper shoes to be coupled together, and described connecting plate matched is set to support bolster 212.In addition, described bolster 212 can adopt any material meeting the human engineering of human body head and cervical region known in the art to form, and such as, described bolster is the bolster of portable, inflatable bolster or other implants, to provide comfort level.
In other embodiments of the present invention, the described Part I of headrest 210 is arranged to become the angle of 50 ° to 70 ° to support by a part for internal stent 211, such as, the angle of 50 ° is become to support by a part for internal stent 211, or become the angle of 70 ° to support by a part for internal stent 211, preferably, the angle of about 60 ° is become to support, so that user or user carry out the via intranasal application brain-targeted drug delivery of dorsal position; The Part II of headrest 210 is arranged to become the angle of 20 ° to 40 ° to support by another part of internal stent 211, such as, the angle of 20 ° is become to support by another part of internal stent 211, or become the angle of 40 ° to support by another part of internal stent 211, preferably, the angle of about 30 ° is become to support, so that user or user carry out the via intranasal application brain-targeted drug delivery of lateral position.By making headrest 210 rotate optionally to use described Part I and Part II around central shaft rod 230, and then select to take different positions to carry out via intranasal application brain-targeted drug delivery.Preferably, such as, can by the angle of headrest 210 adjusting central shaft rod 230 and be connected with the mechanical arm (not shown) that head supporting part 200 operatively engages.As selection, the micromachine (not shown) with angular display unit operatively engaged with described head supporting part can be adopted, for adjusting the angle of described headrest under control of the computer, thus, accurately control the position of user to make the medicine of via intranasal application administration be absorbed into brain best.
[embodiment 3]
Fig. 8 shows the head supporting part 300 with height adjusting function of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention, and its bolster 312 takes foreshortened figure, that is: can see that it is inner through bolster 312.In an exemplary embodiment of the present invention embodiment, user remains on and is suitable for promoting medicine to enter upper nasal cavity and being entered the position of brain further by regio olfactoria by described body position fixture.As shown in Figure 8, described head supporting part 300 includes, but are not limited to: for carry the head of user headrest 310, for the bracing frame 320 that supports described headrest 310 and the central shaft rod 330 described headrest 310 is rotatably supported on support frame as described above 320.
Compare with 2 with embodiment 1, the difference of the present embodiment 3 is that described head supporting part 300 has height adjusting function, and specifically, bracing frame 320 has height adjustment feature.In one embodiment of the invention, two bracing frames 320 are respectively roughly in H-shaped, wherein, each bracing frame 320 comprises two root posts 321 and a horizontal linking arm 322, differing heights position wherein on single upright column 321 has otch 323, the height one_to_one corresponding of otch on each Self-stabilised post 321 on described two root posts 321, the two ends of described horizontal linking arm 322 have protruding 324 respectively, described protruding 324 are positioned on described two root posts 323 in mutually level otch 323 respectively, thus two root posts 324 are coupled together form bracing frame 320.Described central shaft rod 330 is connected with the middle body of described horizontal linking arm 322, such as, the middle body providing holes of horizontal linking arm 322 or opening are to receive the end of described central shaft rod 330, or by other modes known in the art, horizontal linking arm 322 is connected rotationally with central shaft rod 330, thus headrest 310 is supported on bracing frame 320 rotationally.By in the otch 323 that the projection 324 of horizontal linking arm 322 is positioned over height different on column 321 to regulate the height of horizontal linking arm 322, and then regulate the height of central shaft rod 330, and regulate the height of headrest 310 thus, thus meet the needs of Different Individual, different position, user for administration provides better comfort level, and support frame as described above can be positioned on any horizontal plane.
It should be noted that, the present invention is not limited to and the bracing frame of H-shaped is arranged to have height adjusting function, bracing frame for other shapes can be adopted and be arranged to have height adjusting function in the same way, such as, otch is arranged to adjust the height of its horizontal linking arm to the differing heights on the oblique column of A shape bracing frame.In addition, carry out except altitude mixture control except adopting the mode arranging otch, the bracing frame of other altitude mixture control modes known in the art to the various embodiment of the present invention can also be adopted to be configured to realize altitude mixture control, such as, pulley-type elevating mechanism, hydraulic pressure lifting mechanism etc. can be adopted.
According to other embodiments of the present invention, the side of headrest 310 can be roughly tetragon, whole headrest is made up of internal stent and outside soft bolster implant, can be divided into upper and lower two (can put upside down) (namely above-mentioned Part I, Part II), centre has rotatable central shaft rod 330 to pass.On headrest 310 surface, soft bolster packing material is selected to be covered in internal stent (being similar to the internal stent 111 in embodiment 1), to provide comfort level.310 upper design of resting the head on for by internal stent support and allow about 60 ° (such as, 50 °-70 °) around axis angle rotatable so that user take health to lie on the back and head layback posture carry out via intranasal application brain-targeted drug delivery.Rest the head on 310 bottoms be designed to by internal stent support and allow about 30 ° (20 °-40 °) around axis angle rotatable so that user takes lateral position to carry out via intranasal application brain-targeted drug delivery.Preferably, such as, can by the angle of headrest 310 adjusting central shaft rod 330 and be connected with the mechanical arm that head supporting part 300 operatively engages.As selection, the micromachine (not shown) with angular display unit operatively engaged with described head supporting part can be adopted, for adjusting the angle of described headrest under control of the computer, thus, accurately control the position of user to make the medicine of via intranasal application administration be absorbed into brain best.
[embodiment 4]
It will be appreciated by those skilled in the art that whole feature or the Partial Feature of the embodiment described in embodiment 1,2 can be combined or be merged in embodiment 3 with embodiment 3, or can by the Partial Feature in the Partial Feature alternate embodiment 3 in embodiment 1,2.Described combination, merging, substitute formed embodiment also belong to embodiments of the present invention, and fall into the claims in the present invention limit protection domain within.Such as, Fig. 9 shows the embodiment 4 of the head supporting part of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention, represents with 400.In fig .9, bolster 412 takes foreshortened figure, that is: can see that it is inner through bolster 412.In an exemplary embodiment of the present invention embodiment, described head supporting part 400 can be applied in body position fixture, and user remains on and is suitable for promoting medicine to enter upper nasal cavity and being entered the position of brain further by regio olfactoria by this body position fixture.As shown in Figure 9, described head supporting part 400 includes, but are not limited to: for carry the head of user headrest 410, for the bracing frame 420 that supports described headrest 410 and the central shaft rod 430 described headrest 410 is rotatably supported on support frame as described above 420.Wherein, bracing frame 420 is similar with the bracing frame 320 in embodiment 3, has similar height adjustment feature; Headrest 410 is similar with the headrest 210 in embodiment 2, its internal stent 411 adopting gripper shoe 413 to form.Miscellaneous part or feature and embodiment 1,2 or 3 similar.
According to the embodiment of the present invention, the side of headrest 410 also can be roughly tetragon, whole headrest is made up of internal stent and outside soft bolster implant, can be divided into upper and lower two (can put upside down) (namely above-mentioned Part I, Part II), centre has rotatable central shaft rod 430 to pass.On headrest 410 surface, soft bolster packing material is selected to be covered in interior shelf 420, to provide comfort level.410 upper design of resting the head on are for be supported by internal stent 411 and to allow about 60 ° (such as, 50 °-70 °) around axis angle rotatable, so that user takes health to lie on the back and the posture that head is swung back carries out via intranasal application brain-targeted drug delivery.410 bottoms of resting the head on are designed to be supported by internal stent 411 and allow about 30 ° (20 °-40 °) around axis angle rotatable, so that user takes lateral position to carry out via intranasal application brain-targeted drug delivery.Such as, the micro machine (not shown) with angular display unit operatively engaged with described head supporting part can be adopted, for adjusting the angle of described headrest under control of the computer.In addition, by height adjustment to meet the needs of Different Individual, different position, the user for administration provides better comfort level.
[embodiment 5]
Figure 10 shows the head supporting part 500 with height adjusting function and graduation indication of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention, its bolster 512 takes foreshortened figure, that is: can see that it is inner through bolster 512.In an exemplary embodiment of the present invention embodiment, described head supporting part 500 can be applicable in body position fixture, and user remains on and is suitable for promoting medicine to enter upper nasal cavity and being entered the position of brain further by regio olfactoria by this body position fixture.As shown in Figure 10, described head supporting part 500 includes, but are not limited to: for carry the head of user headrest 510, for the bracing frame 520 that supports described headrest 510 and the central shaft rod 530 described headrest 510 is rotatably supported on support frame as described above 520.Wherein, bracing frame 520 and the bracing frame 320 in embodiment 3,4,420 similar, there is similar height adjustment feature; Headrest 510 is similar with the headrest 110 in embodiment 1, its internal stent 511 adopting support bar 513, many long connecting rods 514 and short connecting rod 515 to form.Miscellaneous part or feature and embodiment 1,2,3 or 4 similar.From the different of above-described embodiment, embodiment 5 is that described Postural immobilization also comprises division indicator (not shown), the elevation angle that this division indicator accurately detects the nose-collar of user by laser instrument 540 Emission Lasers light beam indicates user nose to need the angle of adjustment.Such as, number known in the art controls the graduation apparatus indicator of (or similar effect), this indicator is furnished with the angle of laser in order to parallel nose, user can be made to regulate the angle of nose accurately by laser designation, reach the requirement position of the via intranasal application brain-targeted drug delivery of Mygind position (as shown in figure 11) or Regan position (as shown in figure 12).
[embodiment 6]
Figure 13 shows the head supporting part 600 with height adjusting function of the body position fixture of the via intranasal application administration for Brain targeting according to embodiment of the present invention.In an exemplary embodiment of the present invention embodiment, described head supporting part 600 can be applicable in body position fixture, and user remains on and is suitable for promoting medicine to enter upper nasal cavity and being entered the position of brain further by regio olfactoria by this body position fixture.As shown in figure 13, described head supporting part 600 includes, but are not limited to: for carry the head of user headrest 610, for the bracing frame 620 that supports described headrest 610 and the central shaft rod 630 described headrest 610 is rotatably supported on support frame as described above 620.Wherein, headrest 610 comprises two-sided bolster, and described double-faced pillow spacer has the supine face of page in the first surface 611(figure for dorsal position administration) and for the ventricumbent face of page in second 612(figure of lateral position administration).Described first surface 611 comprises cervical region loading end and carrier of head face, and the profile design of these two loading ends becomes human body incidence curve 613 when lying on the back of fitting respectively.Described second face 612 comprises cervical region loading end and carrier of head face, and the profile design of these two loading ends becomes human body incidence curve 614 when lying on one's side of fitting respectively, and wherein, the radian of curve 614 is greater than the radian of curve 613.Wherein, the horizontal end through the cervical region loading end of the two-sided bolster of described headrest of central shaft rod 630, by rotating optionally to use its first surface and second.As selection, by mechanical arm (not shown) adjustment central shaft rod 630 and the angle of headrest 610 connected thereof, regio olfactoria can be administered to realize via intranasal application, finally realize brain-targeted drug delivery.As selection, the micromachine (not shown) with angular display unit operatively engaged with described head supporting part can be adopted, for adjusting the angle of described headrest under control of the computer.
In the present embodiment, bracing frame 620 comprises two H-shaped supports, each H-shaped support is made up of with the horizontal linking arm 622 being connected described column two vertical columns 621, in the "-" in the middle of the horizontal linking arm 622(" H " that two ends of central shaft rod 630 are supported on corresponding H-shaped support respectively rotationally) on.In one embodiment of the invention, on each H-shaped support, near the position of column 621, there is limiting component 623,624 at the two ends of horizontal linking arm 622 respectively.Wherein, when described headrest 610 is used as dorsal position administration, state as shown in fig. 13 that, limiting component 623 on two H-shaped supports is for supporting the two ends in the second face 612 of headrest 610 respectively, thus headrest 610 is supported for is suitable for carrying out dorsal position administration, make medicine arrive regio olfactoria through nasal cavity, and then infiltrate to brain.Correspondingly, when described headrest 610 is used as lateral position administration, headrest 610 for supporting the two ends of the first surface 611 of headrest 610 respectively, thus is supported for and is suitable for carrying out dorsal position administration by two limiting components 624, make medicine arrive regio olfactoria through nasal cavity, and then infiltrate to brain.It should be noted that, it will be appreciated by those skilled in the art that the present invention is not limited to this, the function of described limiting component can adopt the whippletree coupled together by two horizontal linking arms to realize, and other modes known in the art can certainly be adopted to realize.In addition, bracing frame 620 has height adjustment feature similar to Example 3, by height adjustment to meet the needs of Different Individual, different position, for user provides better comfort level.It will be appreciated by those skilled in the art that the present invention is not limited to this, support frame as described above can be A shape, L shape, Y shape, M shape or other exercisable shapes.In addition, the two-sided bolster in the present embodiment can replace the bolster in the various embodiments described above, and the embodiment formed thus falls into the scope of the claims in the present invention request protection equally.In other embodiments of the present invention, described two-sided bolster can be the bolster of portable, inflatable bolster or other implants.
In above-described embodiment 1-6, the body position fixture that various embodiment according to the present invention describes can comprise further: audio player, for playing the audio file instructing user to regulate position; And/or video player, for playing the video file instructing user to regulate position.Such as, help user adjustment head position by be applicable to smart mobile phone, remote controller or other the prompting plug-in units can wearing smart machine adding some audio or videos, reach the regulation of pre-set programs.
Body position fixture according to above-mentioned various embodiment, by one flexibly rotatable headrest help user and realize the administration of specific head position, make user or medical assistant can make full use of the specific above-mentioned head shoulder position of this device formation and the anatomic space of upper nasal cavity, satisfied to realize after nasal-cavity administration, at regular time and quantity, the Brain targeting drug level of individuation, thus ensure that medicine is to the therapeutical effect of central nervous system disease.
Body position fixture according to different embodiment various in the above embodiments 1-6, can comprise further: support above-mentioned head supporting part and the platform of user health, specifically, described platform comprises: mat, bed, chair, desk, sales counter, floor and other similar supporting plane.In other embodiments of the present invention, described platform can carry out angular adjustment (as shown in figure 16) in order to the loading end carrying user health, to coordinate the angle of described headrest, make user keep more comfortable individuation per nasal brain-targeted drug delivery position.Such as, all kinds of different platform can be installed or be positioned over to device for adjusting head and nose position, this includes but not limited to chair, desk, desk, the sales counter of mat (similar Yoga mat), common or with gemel bed, common or mechanization, or is directly positioned on floor.As shown in figure 16, described head supporting part is installed on the supporting plane with the supporting mechanism of reclining regulatory function so that the incidence of user does not need excessively layback can carry out the via intranasal application administration of Brain targeting, thus raising comfort level, and then provide the per nasal brain-targeted drug delivery of individuation.
More than in conjunction with various embodiment, describe the body position fixture of the via intranasal application administration for Brain targeting, especially, the head supporting part that this body position fixture relates to.Below the via intranasal application doser of a kind of Brain targeting provided by the invention is described.
In the various embodiments of the present invention, the via intranasal application doser of Brain targeting comprises: above in conjunction with the body position fixture described in various embodiment, for the position of user being held in the regio olfactoria enabling the medicine of via intranasal application administration enter specific upper nasal cavity; Administrator, its administration end has the shape coordinated with the nasal cavity of user, to user administration, enters brain to make medicine orientation for the via intranasal application when user is held in above-mentioned position by described body position fixture.Specifically, the shape of the administrator of embodiment of the present invention, materials meet the demand of nasal-cavity administration, can be good at identical mankind's nasal cavity anatomical physiology structure, and do not stimulate nasal mucosa.
In other embodiments of the present invention, the via intranasal application doser of described Brain targeting also comprises:
Mechanical arm, its one end is connected with described administrator, and described mechanical arm is configured to regulate to be supported in place by described administrator.As selection, the other end of described mechanical arm is connected with described body position fixture.
In other embodiments of the present invention, alternatively, the via intranasal application doser of described Brain targeting comprises further: Based Intelligent Control element, time of administration, speed and dosage is regulated for the action by controlling described administrator and the second mechanical arm, and can by receiving, processing, integrate the information of extraneous input, as the physical signs, biochemical indicator, cognitive function scoring etc. of user, automatically control, regulate the administration time of administrator, speed and dosage according to the information of input.
In the various embodiments of the present invention, described administrator can comprise medicament reservoir.Preferably, described medicament reservoir is good biocompatibility, aseptic and/or disposable container.Described medicament reservoir can be fixed volume container, or can quantitatively promote or the syringe of pressurizing unit for having.Such as, the scope of described fixed volume is 10 μ L-10mL, preferably 25 μ L-2mL.
According to the description of the via intranasal application doser of above-mentioned Brain targeting and the various embodiments of body position fixture thereof, by user being remained on specific position, (namely Mygind position, sees Figure 14 to the technology of via intranasal application administration Brain targeting provided by the invention; Or Regan position, see Figure 15) carry out dosing techniques, thus promote that medicine is by entering upper nasal cavity, and enter brain by regio olfactoria further, play the effect of brain-targeted drug delivery, and avoid dosage to inhale road or/and digestive tract with entering not, as shown in figure 17, it illustrates nasal cavity internal anatomy during dorsal position administration.The via intranasal application doser of the Brain targeting according to the various embodiment of the present invention, the shape of its administrator can cater to human nasal anatomy structure, is convenient to fill in nasal cavity and carries out administration.And described device can with the form of drop or spraying, give the medicine of predetermined, concrete dosage can be different according to the characteristic of various disease, different pharmaceutical, but consider the volume restriction of intranasal administration, in this device hold medicine cumulative volume scope between 10 μ L-10mL, preferred volume is 25 μ L-2mL.The medicine loaded can be any one in micromolecule, polypeptide, protein, biological preparation, also can be the compound recipe combination of any one above medicine above-mentioned.Wherein, drop is liquid, and spray can be liquid also can be pressed powder.Said medicine can be natural drug, Chinese medicine, also can be any preparation through processing.When medicine is liquid dosage form, the ratio of absorption enhancer contained in this dosage form is 0%-30%(mass ratio), this absorption enhancer is more than one combinations a kind of many of ion-type or nonionic surfactant, sodium cholate class, cyclodextrin, fatty acid, phospholipid, cyclic peptide apoplexy due to endogenous wind.Said medicine indication comprises any disease relevant to central nervous system.
Specifically, device described in the various embodiment of the present invention may be used for insulin and the derivant thereof of loading various dosage form, comprising various animal origin or utilize gene recombination technology to obtain insulin human abrupt release dosage form, rapid delivery forms, Continuous slow release dosage form, extended release formulations, insulin zinc protamine or above-mentioned 2 kinds or two or more dosage form compound recipe, in order to treatment, the clinical symptoms improving Alzheimer (AD).
As mentioned above, described device can be disposable sterile administration device, also can be can the device of Reusability by dosing.
Adopt the via intranasal application doser of the Brain targeting described in the various embodiment of the present invention and body position fixture thereof to carry out administration and include but not limited to the following step:
(1) administration object need be taked to lie low or other suitable positions, so that come back make lower jaw upward (as Figure 14, shown in Figure 15), remain on the angle of human body head vertical axis and horizontal plane between 0 ° to 90 °, preferably between 40 ° to 80 °, object is to allow nostril upward or oblique upper, thus contributes to administration, and make medicine enter nasal cavity, as shown in figure 17.
(2) described doser is inserted any one nostril, by the infusion of medicine of this device internal fixtion volume, maintain above-mentioned position at least 1 minute, make medicine upwards nasal cavity direction flowing, as shown in figure 17.
(3) remove described doser, temporarily block offside non-administration nostril, still maintain above-mentioned position, by the dark air-breathing of nose, be beneficial to medicine and enter nasal cavity.
(4) maintain above-mentioned position, to opposite side nostril, repeat step (2) and step (3).
(5) again pin nostril, both sides in turn, respectively with the dark air-breathing of nose once.
(6) above-mentioned position at least 1 minute is maintained, dark air-breathing more than 30 times.
It should be noted that, order, head and the body angle of above-mentioned step (1) to (6), to hold time and inspiratory times etc. can change to some extent, in other words, those skilled in the art are under the condition not departing from aim of the present invention, various change can be carried out based on the principle of the upper nasal cavity of medicine introducing being conducive to described doser to be injected, thus directly enter brain by regio olfactoria.
By the lower jaw posture upward of taking steps described in (1), make nasal cavity be positioned at whole nasal cavity bottom, utilize action of gravity to accumulate medicine drain in regio olfactoria.Multiple through then out nose FI enters upper nasal cavity to greatest extent in order to ensure medicine, and non-entry respiratory tract or digestive tract, cause periphery to absorb the side effect caused.Period repeatedly requires that maintaining position at least 1 minute is to make medicine have the sufficient time to contact with regio olfactoria nervi olfactory, thus directly enters central nervous system, plays drug effect.This administering mode is easy and simple to handle, and being in by user just can complete independently, and for handicapped user, only needs the assistance of family members or nursing staff, also easily can complete administration accurately.
According to description above, technical solution of the present invention may be used for improving the early stage cognitive disorder of Alzheimer.By above-mentioned via intranasal application doser, adopt described position and dosing step, make insulin or derivatives thereof be that the various pharmaceutical preparatioies of main active directly enter brain by nasal cavity, play therapeutical effect.Further, can according to the state of an illness, once a day or twice, continuous a couple of days, several months and even several years.Recorded by the periodic preliminary spiritual Cognitive Aptitude Test of other party and evaluated, the cognitive function of user is improved preferably.In addition, technical solution of the present invention can also be used for the treatment of the disease that brain tumor, multiple sclerosis, parkinson disease, epilepsy, acquired immune deficiency syndrome (AIDS), tuberculosis, brain viral or bacterial infection, pituitary-hypothalamic hormonoprivia or imbalance cause, and for alleviating the relevant symptom of central nervous system.
In sum, the via intranasal application doser of the Brain targeting provided by adopting embodiment of the present invention overcomes the following defect of prior art: the disease of current many central nervous system needs to rely on the treatment of Brain targeting, but due to operational professional difficulty, and potential through respiratory tract or/and the peripheries such as digestive tract absorb side effect, nose administration Brain targeting technology is applied and is fully promoted always.The application of the via intranasal application doser of the Brain targeting that embodiment of the present invention provides, by contributing to making the popular and individuation of very complicated, high-end Brain targeting nasal-cavity administration technology, more user can be had technically, have the ability to bear the treatment means of nose administration Brain targeting economically.Although Giving Insulin by Pernasal Method has potential improvement, the existing research report for the treatment of Alzheimer disease, distinguishedly be, the present invention aims to provide above-mentioned doser for improving the effect of the early stage cognitive dysfunction of this disease, if be aided with by periodic logging and evaluate preliminary spiritual Cognitive Aptitude Test, and insulinemia/cerebrospinal fluid detection of drug concentration that the present invention combining necessity relates to, to contribute to evaluating and determining therapeutic effect, benefit numerous patients with Alzheimer disease.
The term used in description of the present invention and wording, just to illustrating, are not meaned and are formed restriction.It will be appreciated by those skilled in the art that under the prerequisite of the ultimate principle not departing from disclosed embodiment, can various change be carried out to each details in above-mentioned embodiment.Therefore, scope of the present invention is only determined by claim, and in the claims, except as otherwise noted, all terms should be understood by the most wide in range rational meaning.
Claims (29)
1. for a body position fixture for the via intranasal application administration of Brain targeting, it is characterized in that, this body position fixture comprises:
Head supporting part, for carrying the head of user and head being held in the regio olfactoria enabling the medicine of via intranasal application administration enter upper nasal cavity.
2. body position fixture as claimed in claim 1, it is characterized in that, described head supporting part comprises:
Headrest, for carrying the head of user;
Bracing frame, for supporting described headrest;
Central shaft rod, is rotatably supported on described headrest on support frame as described above.
3. body position fixture as claimed in claim 2, it is characterized in that, described headrest comprises:
Internal stent, is supported in described central shaft rod;
Bolster, is covered in described internal stent.
4. body position fixture as claimed in claim 3, it is characterized in that, described headrest is divided into Part I and Part II;
Wherein, Part I is arranged to become the angle of 50 ° to 70 ° to support by a part for described internal stent; And/or
Described Part II is arranged to become the angle of 20 ° to 40 ° to support by another part of described internal stent.
5. body position fixture as claimed in claim 2, it is characterized in that, described headrest comprises:
Two-sided bolster, comprises first surface for dorsal position administration and for lateral position administration second.
6. body position fixture as claimed in claim 5, it is characterized in that, described first surface comprises cervical region loading end and carrier of head face, and described carrier of head face becomes human body incidence curve when lying on the back of fitting respectively with the profile design of cervical region loading end.
7. body position fixture as claimed in claim 5, it is characterized in that, described second face comprises cervical region loading end and carrier of head face, and described carrier of head face becomes human body incidence curve when lying on one's side of fitting respectively with the profile design of cervical region loading end.
8. the body position fixture as described in claim 3 to 7 any one, is characterized in that,
Described bolster is the bolster of portable, inflatable bolster or other implants.
9. body position fixture as claimed in claim 2, is characterized in that,
Support frame as described above is roughly H-shaped, A shape, L shape, Y shape, M shape or other exercisable shapes.
10. body position fixture as claimed in claim 3, is characterized in that,
Described central shaft rod is laterally through the Part I of described headrest and the central authorities of Part II interface.
11. body position fixtures as claimed in claim 5, is characterized in that,
Described central shaft rod is laterally through the end of the cervical region loading end of described two-sided bolster.
12. body position fixtures as claimed in claim 2, it is characterized in that, described head supporting part also comprises:
Height regulating mechanism, for adjusting described central shaft rod and the headrest that the connects height on support frame as described above thereof to adjust the height of described headrest.
13. body position fixtures as claimed in claim 2, it is characterized in that, described body position fixture also comprises:
First mechanical arm, operatively engages with described head supporting part, for adjusting the angle of described headrest.
14. body position fixtures as claimed in claim 2, it is characterized in that, described body position fixture also comprises:
Motor, operatively engages with described head supporting part, for maybe can wear smart machine at computer, smart mobile phone, remote controller control under adjust the angle of described headrest.
15. body position fixtures as claimed in claim 2, it is characterized in that, described body position fixture also comprises:
Division indicator, this division indicator accurately detects the nose of user by laser beam, the elevation angle of collar indicates user nose to need adjustment can carry out the administration angle of per nasal brain-targeted drug delivery.
16. body position fixtures as claimed in claim 2, it is characterized in that, described body position fixture also comprises:
Audio player, for playing the audio file instructing user to regulate position; And/or
Video player, for playing the video file instructing user to regulate position.
17. body position fixtures as claimed in claim 2, it is characterized in that, described body position fixture also comprises:
Support the platform of described head supporting part and user health.
18. body position fixtures as claimed in claim 17, it is characterized in that, described platform comprises: mat, bed, chair, desk, sales counter, floor and other similar supporting planes.
19. body position fixtures as claimed in claim 17, is characterized in that, described platform can carry out angular adjustment in order to the loading end carrying user health, to coordinate the angle of described headrest, make user remain on the position that can carry out per nasal brain-targeted drug delivery.
20. body position fixtures as described in claim 1 to 19 any one, it is characterized in that, described body position fixture is used for the drug treatment of central nervous system disease, comprise that brain degeneration disease, old man's dementia, Alzheimer, brain tumor, multiple sclerosis, parkinson disease, epilepsy, acquired immune deficiency syndrome (AIDS), tuberculosis, brain are viral, bacillary, disease that parasite or other infected by microbes, pituitary-hypothalamic hormonoprivia or imbalance cause, and for the antidotal therapy of auxiliary nervous property poison.
The via intranasal application doser of 21. 1 kinds of Brain targeting, is characterized in that, comprising:
Body position fixture as described in claim 1 to 20 any one, for being held in the regio olfactoria enabling the medicine of via intranasal application administration enter upper nasal cavity by the position of user; With
Administrator, its administration end has the shape coordinated with the nasal cavity of user, enters brain for the via intranasal application when user is held in above-mentioned position by described body position fixture to user administration to make medicine orientation.
22. devices as claimed in claim 21, it is characterized in that, described device also comprises:
Second mechanical arm, its one end is connected with described administrator, and described second mechanical arm is configured to regulate to be supported in place by described administrator.
23. devices as claimed in claim 22, it is characterized in that, the other end of described second mechanical arm is connected with described body position fixture.
24. devices as described in claim 22 or 23, it is characterized in that, described device also comprises:
Based Intelligent Control element, regulates time of administration, speed and dosage for the action by controlling described administrator and the second mechanical arm.
25. devices as claimed in claim 24, it is characterized in that, described Based Intelligent Control element has following function: receive, process, integrate the information of extraneous input, automatically controls, regulates the administration time of administrator, speed and dosage according to inputted information,
Wherein, the information of described input comprises the physical signs of user, biochemical indicator, cognitive function scoring.
26. devices as claimed in claim 21, it is characterized in that, described administrator comprises medicament reservoir.
27. devices as claimed in claim 26, is characterized in that, described medicament reservoir is good biocompatibility, aseptic and/or disposable container.
28. devices as described in claim 26 or 27, it is characterized in that, described medicament reservoir is fixed volume container, or can quantitatively promote or the syringe of pressurizing unit for having.
29. devices as described in claim 21 to 28, it is characterized in that, described device is used for the drug treatment of central nervous system disease, comprise that brain degeneration disease, old man's dementia, Alzheimer, brain tumor, multiple sclerosis, parkinson disease, epilepsy, acquired immune deficiency syndrome (AIDS), tuberculosis, brain are viral, bacillary, disease that parasite or other infected by microbes, pituitary-hypothalamic hormonoprivia or imbalance cause, and for the antidotal therapy of auxiliary nervous property poison.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410072934.6A CN104874095A (en) | 2014-02-28 | 2014-02-28 | Brain-targeted intranasal administration apparatus and body position fixing device thereof |
| PCT/CN2015/072648 WO2015127857A1 (en) | 2014-02-28 | 2015-02-10 | Brain-targeted nasal drug delivery device and body position fixator thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410072934.6A CN104874095A (en) | 2014-02-28 | 2014-02-28 | Brain-targeted intranasal administration apparatus and body position fixing device thereof |
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| CN104874095A true CN104874095A (en) | 2015-09-02 |
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| CN (1) | CN104874095A (en) |
| WO (1) | WO2015127857A1 (en) |
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| CN111297621A (en) * | 2018-09-30 | 2020-06-19 | 日照轩宜信息科技有限公司 | Seat capable of automatically spraying and administering medicine |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN113876503B (en) * | 2021-10-26 | 2022-09-09 | 南通市第一人民医院 | Multi-purpose equipment for medicine administration of patients with intracardiac diseases |
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| WO2015127857A1 (en) | 2015-09-03 |
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