CN104864898B - The critique system and method for measurement value sensor in bio-incubator - Google Patents
The critique system and method for measurement value sensor in bio-incubator Download PDFInfo
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- CN104864898B CN104864898B CN201410058969.4A CN201410058969A CN104864898B CN 104864898 B CN104864898 B CN 104864898B CN 201410058969 A CN201410058969 A CN 201410058969A CN 104864898 B CN104864898 B CN 104864898B
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Abstract
The present invention provides a kind of critique system of measurement value sensor in bio-incubator, comprising: case inner sensor, case outer sensor, gas pipeline, air valve, air pump and controller.Its raising middle flask inner sensor, case outer sensor are got up by gas pipeline connection, and are located at the both ends of gas pipeline.Air valve is used to control the on-off of gas pipeline.Air pump is used to control the direction that gas flows in gas pipeline.Controller is used to select the operating mode and check and correction mode of bio-incubator, and closes the air valve and air pump of gas pipeline in the operational mode, and the air valve and air pump of gas pipeline are opened under check and correction mode.The present invention also provides a kind of proofreading methods of measurement value sensor in bio-incubator.The present invention controls the switch of air valve and air pump by controller, and to realize the extraction to sample, the influence to incubator is smaller, therefore does not need to interrupt culture.In addition, the design can also avoid the null offset of carbon dioxide sensor well.
Description
Technical field
The present invention relates to a kind of critique system of measurement value sensor in bio-incubator more particularly to bio-incubator with
Method.
Background technique
Carbon dioxide bio-incubator is to be woven in biology by simulating one similar cell/group of formation in incubator box body
Intracorporal growing environment, such as stable temperature (37 °C), stable carbon dioxide level (5%), constant pH value (pH value:
7.2-7.4), higher relative saturation humidity (95%) carries out a kind of device of in vitro culture to cell/tissue.It requires case
The parameters such as interior temperature, humidity keep constant value as far as possible, in order to avoid influence the growth of cell.
Current bio-incubator is equipped in cabinet and measures various control amount (such as carbon dioxide content, oxygen content, temperature
Degree, humidity) multiple sensors, in use for some time, their measured value is generally required in shutdown these sensors
In the case of manually proofreaded using reference instrument, the function of few real-time automatic Proofreadings.When sensor goes wrong, nothing
Whether method knows control amount in time accurate, to influence the reliability and stability of each state modulator of incubator.
Especially, nature drift phenomenon can occur for the zero point of carbon dioxide sensor in incubator use process, this existing
As that cannot show in the gas display box of case face, user is also subtle to the result drifted about.Null offset will lead to
Carbon dioxide content is unstable in incubator, influences cell culture.Whether the zero point of carbon dioxide sensor drifts about, and can pass through
Carbon dioxide gas measuring tries instrument detection.The gas into incubator can be adopted from the thief hatch in incubator control panel, is then used
Gas chromatograph can measure gas concentration lwevel, then be compared with the concentration value that incubator is shown, see that the two numerical value is
It is no identical, so that it may to know whether zero point drifts about.It is complete to generally require a chamber door for the correction of carbon dioxide sensor null offset
It opens, carbon dioxide mouth is completely closed, allows air to be emptied completely the carbon dioxide gas in case, then with air come to two
The zero of oxidation carbon sensor is corrected.This method must suspend the training of incubator, and manpower work is needed to grasp
It corrects.
The incubator HF90 and HF100 of power health (Heal Force) company have the unique " Auto- of Heal Force company
Start " or " Auto-Zero " carbon dioxide sensor automatic calibration function, solve due in carbon dioxide sensor use
Null offset and the problem that causes gas concentration lwevel control inaccurate.But this function is just for the zero point of carbon dioxide sensor
Drift corrects, not for the correction of the other sensors such as temperature, humidity, oxygen.
Summary of the invention
In view of this, the present invention provide it is a kind of can be to the critique system and method for various kinds of sensors measured value in incubator.
The critique system of measurement value sensor in bio-incubator of the invention, comprising: case inner sensor, case outer sensor
Got up by gas pipeline connection, and is located at the both ends of gas pipeline；It is provided with air valve on the gas pipeline, for controlling
The on-off of gas pipeline processed；Air pump is also set up on the gas pipeline, for controlling the direction that gas flows in gas pipeline；Control
Device processed for selecting the operating mode and check and correction mode of bio-incubator, and closes the air valve of gas pipeline in the operational mode
With air pump, and under check and correction mode open gas pipeline air valve and air pump.
Preferably, the sensor is placed in the both ends outside the inside or gas pipeline of gas pipeline from nozzle.
Preferably, the case inner sensor and the case outer sensor be the temperature sensor of same type, humidity sensor,
One of carbon dioxide sensor, oxygen sensor.
The proofreading method of measurement value sensor in bio-incubator of the invention enters check and correction mode applied to above system
Under, comprising: controller opens the air valve and air pump in gas pipeline, extracts gas sample to outside case out of case, successively passes through case
Inner sensor and case outer sensor；Judge whether case inner sensor is identical as the measured value of case outer sensor；If they are the same, then it proofreads
It completes；If not identical, case inner sensor is modified referring to case outer sensor.
Preferably, when measurement result is not identical, step further include: controller closes the air valve and gas in gas pipeline
Pump；Case outer sensor is calibrated with standard measuring instruments；Air valve and air pump are opened, is proofreaded again.
Preferably, the step before being proofreaded further include: controller closes the air valve and air pump in gas pipeline；By case
Outer sensor is calibrated with standard measuring instruments.
The present invention controls the switch of air valve and air pump by controller, to realize the extraction to sample, to the shadow of incubator
Sound is smaller, therefore does not need to interrupt culture.In addition, the design can also avoid the zero point of carbon dioxide sensor from floating well
It moves.
Detailed description of the invention
Figure 1A and Figure 1B is the schematic diagram of the real time correction system of measurement value sensor in bio-incubator in the present invention.
Fig. 2 is the schematic diagram of the real time correction method of measurement value sensor in bio-incubator in the present invention.
Specific embodiment
In order to be more clear the objectives, technical solutions, and advantages of the present invention, with reference to the accompanying drawings and embodiments, to this hair
It is bright to be further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and do not have to
It is of the invention in limiting.
Embodiment 1
Please refer to Figure 1A and Figure 1B, the real time correction system of measurement value sensor in the bio-incubator, including
Incubator 1, case inner sensor 2, case outer sensor 3, gas pipeline 4a or 4b, air valve 5, air pump 6 and controller 7.
Case inner sensor 2, case outer sensor 3 are got up by the connection of gas pipeline 4, and are located at the two of gas pipeline 4
End.The inside (such as Figure 1A) or the both ends gas pipeline 4b that two sensors 2,3 can be placed in gas pipeline 4a are from nozzle
(such as Figure 1B), it is ensured that when air-flow passes through gas pipeline, case inner sensor 2 and case outer sensor 3 can be measured successively with a part
Gas, to guarantee the accuracy that two sensors 2,3 are mutually proofreaded.Wherein, case inner sensor 2 and case outer sensor 3 are same
One of various sensors such as temperature sensor, humidity sensor, carbon dioxide sensor, the oxygen sensor of type.
It is provided with air valve 5 on the gas pipeline 4, for controlling the on-off of gas pipeline；It is also set on the gas pipeline 4
Air pump 6 is set, for controlling the direction that gas flows in gas pipeline 4.
Wherein, controller 7 is used to select the operating mode and check and correction mode of bio-incubator 1, and closes in the operational mode
The air valve 5 and air pump 6 of gas pipeline 4a or 4b are closed, and opens the air valve 5 and gas of gas pipeline 4a or 4b under check and correction mode
Pump 6.
Embodiment 2
In step s 201, when incubator works normally, controller enters and keeps working condition.
In step S202, controller closes air valve and air pump, at this point, case inner sensor works normally, provides for system
Influence value.
In step S203, judge whether case outer sensor needs to proofread.In the present embodiment, to case outer sensor into
Row timing regularly check and correction maintenance, to guarantee its reliability.Wherein, it if desired proofreads, then enters step S204；If not needing school
It is right, then enter step S205.
In step S204, case outer sensor is proofreaded using the measuring instrument of standard.
In step S205, judge whether case inner sensor needs to proofread.Wherein, it if desired proofreads, then enters step
S206。
In step S206, controller opens air valve and air pump, and air pump extracts gas sample out of case to outside case, and successively
By case inner sensor and case outer sensor.
In step S207, judge whether the measurement value sensor inside and outside case is identical.It wherein, if they are the same, then can be direct
Complete this proof-reading；If not identical, S208 is entered step.
If in step S208, being modified referring to the numerical value of case outer sensor to case inner sensor.
It should be understood that
The check and correction of the case outer sensor of first, step S203-S204 is can according to actual needs and the type of sensor
Etc. factors, place it in and execute after step S202 or step S207.
Second, after the completion of step S208 is executed, it can be verified again with return step S206 once, be sensed with determining in case
Device is identical as the measured value of case outer sensor, that is, confirmation completes the check and correction of case inner sensor.That is, control system passes through control
For gas in case to different parameters (temperature, humidity, gas content), multiple air valve of opening opens air pump extraction gaseous sample,
Case inner sensor is proofreaded to consistent with the measured value of case outer sensor.At this point, incubator may be at the state normally cultivated,
It does not need to interrupt culture.
The beneficial effects of the present invention are:
By the switch of controller control air valve and air pump, to realize the extraction to sample, the influence to incubator is smaller, because
This does not need to interrupt culture.In addition, the design can also avoid the null offset of carbon dioxide sensor well.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as
Protection scope of the present invention.
Claims (5)
1. the critique system of measurement value sensor in a kind of bio-incubator characterized by comprising
Case inner sensor, case outer sensor are got up by gas pipeline connection, and are located at the both ends of the gas pipeline；
It is provided with air valve on the gas pipeline, for controlling the on-off of the gas pipeline；
Air pump is also set up on the gas pipeline, for controlling the direction that gas flows in the gas pipeline；
Controller for selecting the operating mode and check and correction mode of bio-incubator, and closes the gas transmission in the operational mode
The air valve and air pump of pipeline, and open under check and correction mode the air valve and air pump of the gas pipeline；The case inner sensor,
Case outer sensor is respectively placed in the both ends outside the inside or the gas pipeline of the gas pipeline at nozzle.
2. the critique system of measurement value sensor in bio-incubator as described in claim 1, which is characterized in that in the case
Sensor and the case outer sensor are temperature sensor, humidity sensor, carbon dioxide sensor, the oxygen sensor of same type
One of device.
3. the proofreading method of measurement value sensor in a kind of bio-incubator is applied in any one of claim 1-2
System enters under check and correction mode characterized by comprising
Controller opens the air valve and air pump in gas pipeline, extracts gas sample to outside case out of case, successively by passing in case
Sensor and case outer sensor；
Judge whether case inner sensor is identical as the measured value of case outer sensor；
If they are the same, then completion is proofreaded；
If not identical, case inner sensor is modified referring to case outer sensor.
4. the proofreading method of measurement value sensor in bio-incubator as claimed in claim 3, which is characterized in that when measurement is tied
When fruit is not identical, step further include:
Controller closes the air valve and air pump in gas pipeline；
Case outer sensor is calibrated with standard measuring instruments；
Air valve and air pump are opened, is proofreaded again.
5. the proofreading method of measurement value sensor in bio-incubator as claimed in claim 3, which is characterized in that carrying out school
To preceding step further include:
Controller closes the air valve and air pump in gas pipeline；
Case outer sensor is calibrated with standard measuring instruments.
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| CN108300659A (en) * | 2017-12-30 | 2018-07-20 | 宁波大学 | Cell incubator and its working method |
| CN108444516A (en) * | 2018-03-21 | 2018-08-24 | 广东电网有限责任公司电力科学研究院 | A kind of method and apparatus of assessment sulfur hexafluoride decomposition product detecting system performance |
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| US20040055359A1 (en) * | 2001-06-28 | 2004-03-25 | Rel-Tek | Automatic gas sensor calibration system |
| CN102323380A (en) * | 2011-05-31 | 2012-01-18 | 江苏大学 | Carbon monoxide gas calibrating device and method |
| CN103175589A (en) * | 2011-12-26 | 2013-06-26 | 新奥科技发展有限公司 | Measuring meter calibration device and method |
| CN103374522A (en) * | 2012-04-16 | 2013-10-30 | 北京华慧天行科技有限公司 | Temperature and humidity guaranteeing device of biological culture box |
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