CN104857459B - A kind of Chinese medicine composition for treating heart failure and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating heart failure and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating heart failure, wherein, including the following component being configured according to unit of weight:20 30g of Chinese cassia tree, 20 30g of rhizoma zingiberis, 20 30g of Radix Astragali, 15 25g of Snakegourd Fruit, 15 25g of radix scutellariae, 15 25g of dried orange peel, 15 25g of the root of three-nerved spicebush, 15 25g of Caulis Spatholobi, 15 25g of Herba Lycopi, 15 25g of Radix Codonopsis, 10 20g of Cortex Eucommiae, 15 25g of almond, 10 20g of cacumen biotae, 10 20g of Cortex Magnoliae Officinalis, 10 20g of the stem of noble dendrobium, 10 20g of the root bark of Chinese wolf-berry, 8 15g of Radix Glycyrrhizae.The present invention invigorates vital energy and reinforce the heart, invigorating spleen for diuresis, promoting blood circulation and removing blood stasis, has the function for the treatment of both manifestation and root cause of disease, curative for effect, significant effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of Chinese medicine composition for treating heart failure and its preparation side
Method.
Background technology
Heart failure belongs to the scopes such as traditional Chinese medicine " dyspnea ", " obstruction of qi in the chest ", " palpitaition ",《Plain Questions numbness opinion》It says:" obstruction of the heart qi person,
Arteries and veins is obstructed, tired then severe palpitation, goes up gas cruelly and breathes heavily." it pants, has palpitation, is weak, shortness of breath, and it is dynamic then more so, belong to deficiency of vital energy performance;Chest
Bored, pectoralgia, purplish tongue are the sign of blood-stasis internal-depression;And this kind of patient's course of disease is long, " prolonged illness must be empty ", " pathogen usually intruding into collateral in protracted disease ", therefore it is led
The interpretation of the cause, onset and process of an illness is wanted to press from both sides blood stasis for the deficiency of vital energy deficiency of yang, the deficiency of vital energy deficiency of yang is this, and blood stasis is mark;Sick position is related to lung, kidney in the heart.The traditional Chinese medical science is treated at present
The method of heart failure mainly has " Wen Yang, promoting blood circulation, Li Shui ", and the method for this " cardiac stimulant, expands blood vessel at diuresis " traditional with doctor trained in Western medicine is different
It reaches the same goal on way.Its therapeutic and toxic dose of the digitalis cardiotonic of western medical treatment heart failure application is very close, expansion blood vessel,
Cardiac stimulant, diuresis are the basic skills of western medical treatment heart failure.To sum up, mainly use " promoting blood circulation and removing blood stasis, QI invigorating Wen Yang, profit
The rules for the treatment of such as water clearing damp " often select the plus-minus treatment of the prescriptions such as Shengmai San, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang, Brassicaceae Chinese jujube Lung Soup.Key agents include good fortune
The Cardiac glycosides such as longevity grass, the lily of the valley, periploca sepium, evergreen, lepidium seed, the dried venom of toads and ginseng, monkshood, Radix Astragali, Radix Ophiopogonis, the dried immature fruit of citron orange,
Two kinds of the non-Cardiac glycosides such as ginger, Chinese cassia tree.But the clinical efficacy of traditional Chinese medical science prescription does not obtain significant breakthrough, due to being confined to
The understanding of traditional etiology and pathogenesis, so therapy is in addition to Wen Yang, promoting blood circulation, Li Shui, also purging the lung of pathogenic fire, yin-nourishing, QI invigorating the methods of,
Although result of study has also turned out improvement myocardial contractive power, the effects that improving symptom, breakthrough is not brought.
Heart failure is also referred to as cardiac insufficiency.Heart is because disease, overwork, ejection function weaken, so that blood discharge amount cannot expire
Sufficient organ and the needs of tissue metabolism.Cardinal symptom be have difficulty in breathing, pant, oedema etc..Since myocardial contractive power weakens heart row
Blood volume declines so that tissue and organ perfusion measure deficiency pulmonary circulation or the performance with body circulation hemostasis occurs simultaneously.If left heart failure
Pulmonary venous pleonaemia is had, can be had difficulty in breathing!If right heart failure has stomach and intestine extravasated blood, so apocleisis, nausea, abdominal distension!Cardiac pumping function is poor,
It is bad so lower limb, palpebral edema due to patient's pulmonary venous pleonaemia, cannot lie down so aggravation is patient that peripheral blood returns the heart!But
It is that clinically many patients are whole heart failures, such case more increases treatment difficulty.This heart failure course of disease is longer,
Protracted course of disease, the normal deficiency of yang affecting yin, yin deficiency affecting yang causes yin-yang deficiency, and the state of an illness is complicated, the visible deficiency of vital energy of pathogenesis, the deficiency of yang, the deficiency of Yin,
The performances such as blood stasis, malicious heresy.
Western medical treatment heart failure at present still owes ideal to some cases.Diuretics can make electrolyte imbalance;Digitalis system
Agent individual difference is very big, and dosis toxica and therapeutic dose are close to even overlapping or because to digitalis poor resistance sometimes, in be easy to causeing
Poison leads to arrhythmia cordis;Part vasodilator has certain side effect or unsuitable prolonged application.So we are attempted in using
Doctor's Chinese medicine is treated, and the traditional Chinese medical science thinks that the interpretation of the cause, onset and process of an illness crux point of heart failure is the motive deficiency of yang, the stagnation of the heart blood.Gas deficiency of yang disease position is main
In the heart, there is substantial connection with internal organs such as lung, spleen, kidneys.This characteristic of disease matter belongs to asthenia in origin and asthenia in superficiality more.Heart-yang void is this, and blood stasis, phlegm are turbid to be
Mark.It controls suitable QI invigorating Wen Yang, is promoting blood circulation and removing blood stasis for method, flexibly being used according to clinical practice situation, this disease can be made preferably to be treated.
Heart failure is the card of asthenia in origin and asthenia in superficiality, is motive virtual loss at this, is being designated as blood-vessel obstructive, fluid retention stagnating in the interior." edema with the heart involved " disease of the similar traditional Chinese medical science
Card, when marking actually principal contradiction, Chinese medical book advocates to attach most importance to purgating excessive fluid mostly.Such as《The Standards of Diagnosis and Treatment》Day:If " the motive
Deficiency, kidney water insult it, the inverse upper and person that stops the heart, must roll over inverse gas, rush down its water, mend its sun.The quality of cardiac function be decided by healthy tendency it
Prosperity and decline, in healthy tendency deposits, heresy can not be done.And morbidity, with old artificial highest, the disease in old age is mostly void, so the interpretation of the cause, onset and process of an illness is marked for this void
It is real.Void includes the void of the five internal organs, but to have a guilty conscience as principal contradiction, yang blood and qi must be involved by having a guilty conscience, and is then gently the deficiency of vital energy deficiency of blood, heavy then cloudy
Yang-energy blood is all empty, very then faints de-.Actually it is " phlegm " and " stasis of blood ".As for it is empty with it is real who first after whom the problem of, general theory thinks first
Have void, after just have reality.Having a guilty conscience, it is smooth that qi and blood is caused to lose, and gas and blood, interdependence between yin and yang, qi as the commander of blood, blood being the mother of qi, and blood is with gas row, so far
Capable then blood, gas are actively that blood is passive.The deficiency of vital energy then gives birth to phlegm, and then disorder of qi, the stagnation of the circulation of vital energy cause blood stasis, deficiency of vital energy blood to phlegm-dampness stagnation
It is weak, and blood stasis is caused, blood stasis can react on gas, and the stagnation of the circulation of vital energy or the deficiency of vital energy is caused to be further aggravated.Heart vessel blockage stasis, the stagnant blood stasis of blood is its master
Want the cause of disease.
It is simple therefore, it is necessary to a kind of proportioning occur, easy to use, tonifying Yin and Yang, QI invigorating removing toxic substances, promoting blood circulation and removing blood stasis, QI invigorating temperature
Sun, sharp water clearing damp, improve a kind of Chinese medicine composition for treating heart failure of cardiac pumping ability and preparation method thereof.
Invention content
The technical problems to be solved by the invention are, provide a kind of proportioning simply, easy to use, tonifying Yin and Yang, QI invigorating
Removing toxic substances, promoting blood circulation and removing blood stasis, QI invigorating Wen Yang, sharp water clearing damp improve a kind of Chinese traditional medicine composition for treating heart failure of cardiac pumping ability
Object and preparation method thereof.
In order to solve the above technical problems, the present invention provides a kind of Chinese medicine composition for treating heart failure, wherein, including
The following component being configured according to unit of weight:Chinese cassia tree 20-30g, rhizoma zingiberis 20-30g, Radix Astragali 20-30g, Snakegourd Fruit 15-25g, radix scutellariae
15-25g, dried orange peel 15-25g, root of three-nerved spicebush 15-25g, Caulis Spatholobi 15-25g, Herba Lycopi 15-25g, Radix Codonopsis 15-25g, Cortex Eucommiae 10-20g, apricot
Benevolence 15-25g, cacumen biotae 10-20g, Cortex Magnoliae Officinalis 10-20g, stem of noble dendrobium 10-20g, root bark of Chinese wolf-berry 10-20g, Radix Glycyrrhizae 8-15g.
Alternatively, including the following component being configured according to unit of weight:Chinese cassia tree 20-25g, rhizoma zingiberis 20-25g, Radix Astragali 20-25g,
Snakegourd Fruit 15-20g, radix scutellariae 15-20g, dried orange peel 15-20g, root of three-nerved spicebush 15-20g, Caulis Spatholobi 15-20g, Herba Lycopi 15-20g, Radix Codonopsis 15-
20g, Cortex Eucommiae 10-15g, almond 15-20g, cacumen biotae 10-15g, Cortex Magnoliae Officinalis 10-15g, stem of noble dendrobium 10-15g, root bark of Chinese wolf-berry 10-15g are sweet
Careless 8-12g.
Alternatively, including the following component being configured according to unit of weight:Chinese cassia tree 25-30g, rhizoma zingiberis 25-30g, Radix Astragali 25-30g,
Snakegourd Fruit 20-25g, radix scutellariae 20-25g, dried orange peel 20-25g, root of three-nerved spicebush 20-25g, Caulis Spatholobi 20-25g, Herba Lycopi 20-25g, Radix Codonopsis 20-
25g, Cortex Eucommiae 15-20g, almond 20-25g, cacumen biotae 15-20g, Cortex Magnoliae Officinalis 15-20g, stem of noble dendrobium 15-20g, root bark of Chinese wolf-berry 15-20g are sweet
Careless 10-15g.
Alternatively, including the following component being configured according to unit of weight:Chinese cassia tree 22-28g, rhizoma zingiberis 22-28g, Radix Astragali 22-28g,
Snakegourd Fruit 18-22g, radix scutellariae 18-22g, dried orange peel 18-22g, root of three-nerved spicebush 18-22g, Caulis Spatholobi 18-22g, Herba Lycopi 18-22g, Radix Codonopsis 18-
22g, Cortex Eucommiae 12-18g, almond 18-22g, cacumen biotae 12-18g, Cortex Magnoliae Officinalis 12-18g, stem of noble dendrobium 12-18g, root bark of Chinese wolf-berry 12-18g are sweet
Careless 9-13g.
The present invention can be decocted in water for oral dose, and one one, take in two times within 1st, 10 days as one therapeutic course.
Treat the preparation method of the Chinese medicine composition of heart failure, which is characterized in that
Dosage form is capsule, and preparation method includes the following steps:By described 10 times of amount ethyl alcohol of component add weight, heat back
Stream extraction 3 times 2 hour every time, No. 3 extracting solutions is merged, ethyl alcohol is recovered under reduced pressure, and be concentrated into liquor strength for 0.5g crude drugs/
ML, after suction filtration, 1.08 when the relative density of filtrate is 20 DEG C;The filtrate flows through the large pore resin absorption column that volume is 10L, it
Afterwards with the deionized water or distillation water elution of 10 times of resin column volumes, then 95% ethanol elution with 5 times of resin column volumes, collect
Ethanol eluate removes alcohol solvent, obtains component medicinal powder, is packed into capsule and is made as capsule.
Advantage of the present invention:It invigorates vital energy and reinforce the heart, is invigorating spleen for diuresis, promoting blood circulation and removing blood stasis, there is treating both manifestation and root cause of disease, curative for effect, effect
Fruit is notable.It teaches compared with prior art, the present invention has a clear superiority:After use, there is positive inotropic action to heart, enhance the heart
Myotility increases coronary blood flow, protects cardiac muscle cell, improves cardiac function.The blood of patients with heart failure can be obviously improved
Hydromechanics is disorderly, improves heart function and left ventricular remodeling;Its mechanism may be related with improving myocardial cell energy metabolism.This hair
It is bright effectively to treat heart failure, hemodynamics disturbance is corrected, improves the heart function of heart failure person, improves short term effect;It can be inverse
Turn failure cardiac muscle remodeling ventricle, so as to improve the prognosis at a specified future date of heart failure person;Also prompting can prolonged application and non-evident effect.
Specific embodiment
The Chinese medicine composition of heart failure is treated, wherein, including the following component being configured according to unit of weight:Chinese cassia tree 20-
30g, rhizoma zingiberis 20-30g, Radix Astragali 20-30g, Snakegourd Fruit 15-25g, radix scutellariae 15-25g, dried orange peel 15-25g, root of three-nerved spicebush 15-25g, Caulis Spatholobi
15-25g, Herba Lycopi 15-25g, Radix Codonopsis 15-25g, Cortex Eucommiae 10-20g, almond 15-25g, cacumen biotae 10-20g, Cortex Magnoliae Officinalis 10-20g, stone
Dry measure used in former times 10-20g, root bark of Chinese wolf-berry 10-20g, Radix Glycyrrhizae 8-15g.
Alternatively, including the following component being configured according to unit of weight:Chinese cassia tree 20-25g, rhizoma zingiberis 20-25g, Radix Astragali 20-25g,
Snakegourd Fruit 15-20g, radix scutellariae 15-20g, dried orange peel 15-20g, root of three-nerved spicebush 15-20g, Caulis Spatholobi 15-20g, Herba Lycopi 15-20g, Radix Codonopsis 15-
20g, Cortex Eucommiae 10-15g, almond 15-20g, cacumen biotae 10-15g, Cortex Magnoliae Officinalis 10-15g, stem of noble dendrobium 10-15g, root bark of Chinese wolf-berry 10-15g are sweet
Careless 8-12g.
Alternatively, including the following component being configured according to unit of weight:Chinese cassia tree 25-30g, rhizoma zingiberis 25-30g, Radix Astragali 25-30g,
Snakegourd Fruit 20-25g, radix scutellariae 20-25g, dried orange peel 20-25g, root of three-nerved spicebush 20-25g, Caulis Spatholobi 20-25g, Herba Lycopi 20-25g, Radix Codonopsis 20-
25g, Cortex Eucommiae 15-20g, almond 20-25g, cacumen biotae 15-20g, Cortex Magnoliae Officinalis 15-20g, stem of noble dendrobium 15-20g, root bark of Chinese wolf-berry 15-20g are sweet
Careless 10-15g.
Alternatively, including the following component being configured according to unit of weight:Chinese cassia tree 22-28g, rhizoma zingiberis 22-28g, Radix Astragali 22-28g,
Snakegourd Fruit 18-22g, radix scutellariae 18-22g, dried orange peel 18-22g, root of three-nerved spicebush 18-22g, Caulis Spatholobi 18-22g, Herba Lycopi 18-22g, Radix Codonopsis 18-
22g, Cortex Eucommiae 12-18g, almond 18-22g, cacumen biotae 12-18g, Cortex Magnoliae Officinalis 12-18g, stem of noble dendrobium 12-18g, root bark of Chinese wolf-berry 12-18g are sweet
Careless 9-13g.
Compound Chinese medicinal preparation pharmacodynamic study of the present invention:
1st, after heart qi deficiency model mice application compound Chinese medicinal preparation of the present invention, apparent inhibition makees to anxiety caused by suspension
With;Extend sleeping time;Muscle tensility increases, stand up time extends;Measuring memory using water maze increases;It is resistance under normal pressure
Hypoxic exposure extends;Restore heart qi deficiency mouse heart rate;
2nd, after normal mouse application compound Chinese medicinal preparation of the present invention, have to anxiety caused by forced swimming method and suspension method bright
Aobvious sedation;It is obviously prolonged the sleeping time of mouse;Immune function is significantly improved, swallows mononuclear phagocytic cells
Index and phagocytic activity significantly increase, and mice serum amboceptor significantly increases;
3rd, apparent reduction acts on to the hypertension of neuroendocrine type Hypertensive Rats;Heart rate significantly restores;
Sleeping time significantly extends, and has apparent synergistic effect with yellow Jackets;It is tested with water maze as it can be seen that making rat model
Memory increases, and residence time is obviously shortened in labyrinth;It is tested with head-breaking as it can be seen that Chinese medicine composition of the present invention makes rat
Time of opening one's mouth after broken end is obviously prolonged.
Acute toxicity testing:
The Mouse oral maximum dosage-feeding of Chinese medicine composition of the present invention is 210g crude drugs/kg, is calculated by kg body weight, quite
In 1215 times of adult daily dosage 8.8g, calculated by body surface area, be equivalent to 167 times;Intraperitoneal administration measures its LD50
41.375 crude drugs/kg, 95% credible is limited to 35.243~42.068g crude drugs/kg.Illustrate that compound Chinese medicinal preparation of the present invention takes orally
Toxicity is low, and clinical practice is safer.
Long term toxicity test:
Compound Chinese medicinal preparation of the present invention presses 7.69,19.18 and 43.21g crude drugs/kg continuous uses 12 weeks to mouse
After (1.0ml/100g weight, 2 times a day) and drug withdrawal 3 weeks, the results showed that:Compound Chinese medicinal preparation of the present invention to the hair of rat,
The indexs such as behavior, stool and urine, weight, organ weights, blood picture, hepatic and renal function, blood glucose, blood fat have no significant effect, internal organs naked eyes
After not finding that abnormal variation and histological indications show medication 12 weeks and are discontinued 3 weeks, each internal organs of rat nothing significantly changes
Become.Illustrate compound Chinese medicinal preparation of the present invention to small toxicity after rat long-term administration, also without abnormal reaction after drug withdrawal, using peace
Entirely.
Pharmacological effect
First, influence of the present invention to experimental heart failure domesticated dog coronary artery renal blood flow
1 material and method:
1.1 experiment material:
1.1.1 animal:Healthy adult experimental dog 20,13.27 ± 0.59kg of weight, male and female dual-purpose.
1.1.2 drug:Pill of the present invention;Yellow Jackets;Digoxin 0.25mg/ pieces;Heparin sodium injection;0.9%
Sodium chloride injection.Above-mentioned experimental drug in addition to yellow Jackets, heparin before experiment with normal saline into isometric
3ml/kg, through duodenal administration.
1.2 experiment packet:Experimental animal is randomly divided into four groups, every group 5.A groups:For blank control group, raised in experiment
With physiological saline 3ml/kg;B groups:Low dose group of the present invention, 5g crude drugs/kg;C groups:High dose group of the present invention, 10g crude drugs/kg;D
Group:Positive controls, 100 μ g/kg of digoxin.
1.3 experimental method:Experimental animal yellow Jackets 30mg/kg Intravenous Anesthesias, trachea cannula connect electronic people
Work lung ventilator separation right side femoral vein connection constant speed peristaltic pump, in case input yellow Jackets;Right common femoral artery is detached, is intubated,
Measure arterial pressure BP;The 4th intercostal of left side opens chest, and exposure heart cuts off pericardium, makees pericardium bed, detaches coronary left branch
And aorta, electromagnetic flowmeter probe is placed respectively, measures coronary blood flow CBF and cardiac output CO.Abdominal operation detaches kidney
Artery and placement electromagnetic flowmeter probe, measure renal artery blood flow amount KBF.Above-mentioned indices synchronous recording is remembered in multi-path physiology
Record instrument.Implement abdominal operation, duodenal intubation, in case giving institute's reagent object.Intravenous injection heparin injection 125U/kg is carried out
Test tube of hepari after 30 minutes, records indices, as basic value before dripping pill of the present invention.2% penta bars of ratios are inputted through peristaltic pump constant speed
Appropriate sodium, input quantity 0.2ml/minkg.Using left ventricular pressure variation maximum rate decline 70% as heart failure index,
It is 0.08ml/minkg that the yellow Jackets amount of feeding is adjusted after up to this value, continues 15 minutes, and left ventricular end diastolic presssure is made to keep steady
It is fixed, index after every heart failure is recorded, is worth before medicine.Duodenum feeds institute's reagent object.10 after medicine, 20,30,40,
60th, the every observation index of 90,120,180 minutes records.
1.4 statistical methods are examined using t and X2It examines.
As a result:Two dosage groups of pill of the present invention play the role of different degrees of increase CBF, 90 minutes after medicine, 10g lifes
Medicine/kg dosage groups CBF 20.78 ± 8.06ml/min before medicine increase to 39.61 ± 16.51ml/min, increase by 81.16% ±
17.24%, compared with before medicine P < 0.05 and compared with the control group P < 0.01 there were significant differences.Two agent of pill of the present invention
Amount group influences CO not notable.Two dosage groups can significantly increase KBF, have compared with before medicine and compared with the control group significantly
Difference P < 0.05~0.01.
This study demonstrates that pill of the present invention can effectively improve the blood flow of coronary artery and the arteria renalis, can not only help
The treatment of heart failure caused by heart disease in a variety of causes, and to caused by heart failure coronary artery, renal artery blood flow amount
Reduction and the damage of renal function have the effect of apparent.
Example 1:Sun, man, 59 years old, there is history of coronary heart disease, palpitaition, angina pectoris, arrhythmia cordis, electrocardiogram is shown:Cardiac muscle supplies
Blood is insufficient, ventricular premature beat.Often there is heart failure, when have expiratory dyspnea, it is impossible to lie down, double lower legs have pitting edema, tongue
It is livid purple, deep thready pulse knot generation.Clinical diagnosis:Coronary disease and angina pectoris, arrhythmia cordis, III ° of heart failure.It is treated using following formula:
Chinese cassia tree 30g, rhizoma zingiberis 30g, Radix Astragali 30g, Snakegourd Fruit 25g, radix scutellariae 25g, dried orange peel 25g, root of three-nerved spicebush 25g, Caulis Spatholobi 25g, pool
Blue 25g, Radix Codonopsis 25g, Cortex Eucommiae 20g, almond 25g, cacumen biotae 20g, Cortex Magnoliae Officinalis 20g, stem of noble dendrobium 20g, root bark of Chinese wolf-berry 20g, Radix Glycyrrhizae 15g.
Decoction of the present invention is taken, is taken daily 2 times, is taken medicine 10, symptom mitigates, and takes medicine 30, and arrhythmia cordis reduces, and continues to use
Medicine is consolidated for 6 months, is cured after 1 year clinical, follow-up 6 years is not recurred.
Example 2:Zhang, female, 56 years old, history of coronary heart disease 2 years, palpitaition angina pectoris, atrial fibrillation, electrocardiogram:Deficiency myocardial blood supply, room
It quivers.Clinical main suit:There is expiratory dyspnea when sitting quietly, cannot lie down, fatigue and weak, white phlegm of coughing, double lower limb severe edema, tongue are green
Purple, deep thready pulse knot generation.Clinical diagnosis:Coronary disease and angina pectoris, atrial fibrillation, intrapulmonary infection, III ° of heart failure.Decoction of the present invention is taken, is made
With following formula:
Chinese cassia tree 20g, rhizoma zingiberis 20g, Radix Astragali 20g, Snakegourd Fruit 15g, radix scutellariae 15g, dried orange peel 15g, root of three-nerved spicebush 15g, Caulis Spatholobi 15g, pool
Blue 15g, Radix Codonopsis 15g, Cortex Eucommiae 10g, almond 15g, cacumen biotae 10g, Cortex Magnoliae Officinalis 10g, stem of noble dendrobium 10g, root bark of Chinese wolf-berry 10g, Radix Glycyrrhizae 8g.
Decoction of the present invention is taken, is taken daily 2 times, is taken medicine 15, symptom mitigates, and takes medicine 30, and arrhythmia cordis reduces, and continues to use
Medicine is consolidated for 6 months, is cured after 1 year clinical, follow-up 6 years is not recurred.
Example 3:Lee, male 62 years old, are known as hypertension history, and history of coronary heart disease 3 years was once lived because suffering from acute myocardial infarction AMI
Institute treats, and observes through thromboembolism treatment, leaves hospital after two months, still there is the myocardial damages sign such as uncomfortable in chest, shortness of breath, weak, patient is long-term
Bed, it is impossible to Go to ground activity, slightly aggravation after activity, electrocardiogram prompting oldness heart infarction, and serious S-T segment changes, heart
Ultrasound prompts left room systolic and diastolic function seriously to decline, and radiography shows coronary atherosclerosis, leads to blood vessel Serious Stenosis, and apply
PTCA, III ° of congestive heart failure turn Chinese traditional treatment, cut out Western medicine, change and take medicine pill prepared in accordance with the present invention,
Use following formula:
Chinese cassia tree 25g, rhizoma zingiberis 25g, Radix Astragali 25g, Snakegourd Fruit 20g, radix scutellariae 20g, dried orange peel 20g, root of three-nerved spicebush 20g, Caulis Spatholobi 20g, pool
Blue 20g, Radix Codonopsis 20g, Cortex Eucommiae 15g, almond 20g, cacumen biotae 15g, Cortex Magnoliae Officinalis 15g, stem of noble dendrobium 15g, root bark of Chinese wolf-berry 15g, Radix Glycyrrhizae 10g.
Capsule is made to take.Daily three times, four every time, while add the treatment of heartbeat health, patient symptom after 50 days
The electrocardiogram S-T segments after treating 5 months that are clearly better, which change, to be corrected often, and cardiac ultrasonic shows that Left ventricular systolic function is normal, continues to take
Consolidated with half a year day, do not recurred so far after drug withdrawal.
Example 4:Shandong, male, 58 years old, History of Coronary Heart Disease 2 years, with angina pectoris, hypertension.Sign:There are fever symptoms, body temperature
Still feel palpitaition after normal, pulse is speeded, and pareordia is uncomfortable, body fatigue and weak.Auxiliary examination:White blood cell count(WBC) increases, electrocardio
Figure is abnormal, and myocardial damage ST-T changes, coronary disease and angina pectoris, arrhythmia cordis, III ° of heart failure.Use following formula:Chinese cassia tree 22g,
Rhizoma zingiberis 22g, Radix Astragali 22g, Snakegourd Fruit 18g, radix scutellariae 18g, dried orange peel 18g, root of three-nerved spicebush 18g, Caulis Spatholobi 18g, Herba Lycopi 18g, Radix Codonopsis 18g, Du
Secondary 12g, almond 18g, cacumen biotae 12g, Cortex Magnoliae Officinalis 12g, stem of noble dendrobium 12g, root bark of Chinese wolf-berry 12g, Radix Glycyrrhizae 9g.
Be decocted in water for oral dose and be taken twice daily, by trimestral treatment, the state of an illness become it is stable, but have slight Heart enlargement,
Cardiac kinetic energy decline, arrhythmia cordis or ECG Change, using the treatment of 3 months, patient symptom gradually improved.
Data compare:
1.1 diagnosis and grade scale, heart failure is with reference to Framingham standard diagnostics, and cardiac functional grading is with reference to the U.S.
New York Heart disease association (NYHA) cardiac functional grading scheme performs.
1.2 are included in and exclusion criteria, and clinic is clarified a diagnosis coronary heart disease, hypertensive cardiopathy, cor pulmonale, expansion
Extensional heart disease, rheumatic heart disease, the equal inclusion criteria range of III~IV grades of patients of heart function;Exclude malignant tumour, pericardium
Inflammation, acute myocardial infarction AMI, liver and kidney failure, gestation and nursing period female patient.
1.3 general information, the nearly 3 Nian Lai our hospital internal medicine inpatient of all cases are color through clinical symptoms, sign, heart
Color Doppler measures, and meets III~IV grades by NYHA grade scale heart functions, all cases are randomly divided into treatment group and control
Group.Treatment group 32,50~75 years old age;Heart function III level 20, heart function IV grades 12;Wherein coronary heart disease 15, high blood
Pressure property heart disease 10, cor pulmonale 5, dilated heart disease 1, rheumatic heart disease 1.Control group 32, year
55~75 years old age;Heart function III level 22, heart function IV grades 10;Wherein coronary heart disease 14, hypertensive cardiopathy 10,
Cor pulmonale 6, dilated heart disease 1, rheumatic heart disease 1, two groups in age, the heart failure cause of disease, heart function point
Grade, disease etc. are statistically analyzed, and no significant difference (P > 0.05) is comparable.
2 therapies
2.1 control groups, give conventional therapy, including rest, low sodium diet, oxygen uptake, oral diuretics, ACEI preparations (hydrogen chlorine
Thiazine 25mg, antisterone 20mg, captopril 25mg, 2 times a day), intravenous infusion Potassium Magnesium Aspartate.The too fast person (110 of heart rate
Secondary/min) intravenous injection cedilanid 0.4mg, furosemide 40mg, and give the cause of disease and to the ill supportive treatment temporarily.Some cases are given
0.125~0.25mg of digoxin, takes orally one time a day, when necessary intravenous infusion sodium nitroprussiate and treatment in dopamine.
2.2 treatment groups treat on the basis of control group treatment plus with Chinese medicine of the present invention.Daily 1 dose, decocting into 300ml,
Divide 2 times and warmly take.Two groups with 4 weeks for 1 course for the treatment of.
Record faces in detail before and after treatment for two groups of 2.3 observation index and method】Bed symptom, sign and Minnesota life matter
Amount investigation integration measures the treatment changes of cardiac function indexs such as including SV, CO, CL, EF, before and after treatment using heart color doppler sonography
As Basic examinations such as hepatic and renal functions, and observe adverse reaction.
2.4 statistical method enumeration datas use 2 standards of μ, and measurement data is examined using t.
3 observation of curative effect
3.1 criterion of therapeutical effect:With reference to the Ministry of Public Health《New Chinese medicine guideline of clinical investigations》In related chronic congestion mental and physical efforts
The effect of failure, standard ordered.It is effective:Heart failure controls substantially, and heart function improves 2 grades or more, and symptom and sign and every inspection are bright
It is aobvious to improve.Effectively:Heart function improves 1 grade, but not as good as 2 grades, and symptom and sign and every check make moderate progress.In vain:Heart function carries
High too late 1 grade or even deterioration.
3.2 treatment results
3.2.1 two groups of curative effects compare two groups of total effective rates and compare, and difference has system
Meter learns meaning (P < 0.05), and treatment group's curative effect is substantially better than control group.
(being shown in Table 1)
1 two groups of curative effects of table compare [example (%)]
Group | n | It is effective | Effectively | In vain | Total effective rate |
Treatment group | 32 | 28(87.5) | 3(9.3) | 1(3.1) | 31(96.9)a |
Control group | 32 | 16(50) | 11(34.3) | 5(15.6) | 27(84.4) |
Note:Two groups are compared, aP < 0.05
3.2.2 heart function is poor with more having improvement before treating after two groups of pretherapy and post-treatment heart functions compare two groups of treatments
Different statistically significant (P < 0.01);Treatment group's heart function improves significantly (P < 0.01) compared with the control group after treatment.
(being shown in Table 2)
2 two groups of pretherapy and post-treatment changes of cardiac function of table compare (x ± s)
Note:Compared with before control group treatment, aP > 0.05;Compared with after control group treatment, P < 0.01, with being treated in group
Preceding comparison, cP < 0.05
3.2.3 two groups of adverse reactions are compared:Occur nausea and vomiting 5 in control group therapeutic process, stop over digoxin,
Alleviate after mending the treatments such as potassium, treatment group does not occur obvious adverse reaction.
The present invention invigorates vital energy and reinforce the heart, invigorating spleen for diuresis, promoting blood circulation and removing blood stasis, has the function for the treatment of both manifestation and root cause of disease, curative for effect, effect is shown
It writes.It teaches compared with prior art, the present invention has a clear superiority:After use, there is positive inotropic action to heart, enhance cardiac muscle and receive
Contracting power increases coronary blood flow, protects cardiac muscle cell, improves cardiac function.The blood flow of patients with heart failure can be obviously improved
Mechanics is disorderly, improves heart function and left ventricular remodeling;Its mechanism may be related with improving myocardial cell energy metabolism.The present invention can
Effectively to treat heart failure, hemodynamics disturbance is corrected, improves the heart function of heart failure person, improves short term effect;It can reverse and decline
Myocardium remodeling ventricle is exhausted, so as to improve the prognosis at a specified future date of heart failure person;Also prompting can prolonged application and non-evident effect.
Claims (5)
1. a kind of Chinese medicine composition for treating heart failure, which is characterized in that by being formed according to the bulk pharmaceutical chemicals that unit of weight is prepared
It is as follows:Chinese cassia tree 20-30g, rhizoma zingiberis 20-30g, Radix Astragali 20-30g, Snakegourd Fruit 15-25g, radix scutellariae 15-25g, dried orange peel 15-25g, the root of three-nerved spicebush
15-25g, Caulis Spatholobi 15-25g, Herba Lycopi 15-25g, Radix Codonopsis 15-25g, Cortex Eucommiae 10-20g, almond 15-25g, cacumen biotae 10-20g,
Cortex Magnoliae Officinalis 10-20g, stem of noble dendrobium 10-20g, root bark of Chinese wolf-berry 10-20g, Radix Glycyrrhizae 8-15g.
2. the Chinese medicine composition of heart failure is treated according to claim 1, which is characterized in that by being prepared according to unit of weight
Bulk pharmaceutical chemicals composition it is as follows:Chinese cassia tree 20-25g, rhizoma zingiberis 20-25g, Radix Astragali 20-25g, Snakegourd Fruit 15-20g, radix scutellariae 15-20g, dried orange peel
15-20g, root of three-nerved spicebush 15-20g, Caulis Spatholobi 15-20g, Herba Lycopi 15-20g, Radix Codonopsis 15-20g, Cortex Eucommiae 10-15g, almond 15-20g, side
CedarLeaves 10-15g, Cortex Magnoliae Officinalis 10-15g, stem of noble dendrobium 10-15g, root bark of Chinese wolf-berry 10-15g, Radix Glycyrrhizae 8-12g.
3. the Chinese medicine composition of heart failure is treated according to claim 1, which is characterized in that by being prepared according to unit of weight
Bulk pharmaceutical chemicals composition it is as follows:Chinese cassia tree 25-30g, rhizoma zingiberis 25-30g, Radix Astragali 25-30g, Snakegourd Fruit 20-25g, radix scutellariae 20-25g, dried orange peel
20-25g, root of three-nerved spicebush 20-25g, Caulis Spatholobi 20-25g, Herba Lycopi 20-25g, Radix Codonopsis 20-25g, Cortex Eucommiae 15-20g, almond 20-25g, side
CedarLeaves 15-20g, Cortex Magnoliae Officinalis 15-20g, stem of noble dendrobium 15-20g, root bark of Chinese wolf-berry 15-20g, Radix Glycyrrhizae 10-15g.
4. the Chinese medicine composition of heart failure is treated according to claim 1, which is characterized in that by being prepared according to unit of weight
Bulk pharmaceutical chemicals composition it is as follows:Chinese cassia tree 22-28g, rhizoma zingiberis 22-28g, Radix Astragali 22-28g, Snakegourd Fruit 18-22g, radix scutellariae 18-22g, dried orange peel
18-22g, root of three-nerved spicebush 18-22g, Caulis Spatholobi 18-22g, Herba Lycopi 18-22g, Radix Codonopsis 18-22g, Cortex Eucommiae 12-18g, almond 18-22g, side
CedarLeaves 12-18g, Cortex Magnoliae Officinalis 12-18g, stem of noble dendrobium 12-18g, root bark of Chinese wolf-berry 12-18g, Radix Glycyrrhizae 9-13g.
5. a kind of preparation method for the Chinese medicine composition that heart failure is treated as described in any one of Claims 1 to 4, feature
It is,
Dosage form is capsule, and preparation method includes the following steps:By described 10 times of amount ethyl alcohol of component add weight, it is heated to reflux carrying
It takes 3 times, 2 hours every time, No. 3 extracting solutions is merged, ethyl alcohol is recovered under reduced pressure, and be concentrated into liquor strength as 0.5g crude drugs/mL, taken out
After filter, 1.08 when the relative density of filtrate is 20 DEG C;The filtrate flows through the large pore resin absorption column that volume is 10L, Zhi Houyong
The deionized water or distillation water elution of 10 times of resin column volumes, then 95% ethanol elution with 5 times of resin column volumes, collect ethyl alcohol
Eluent removes alcohol solvent, obtains component medicinal powder, is packed into capsule and is made as capsule.
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"强心煎治疗充血性心力衰竭56例";王明亮等;《中国中医药科技》;19971231;第4卷(第2期);第105页 * |
益气活血中药配合西药治疗充血性心力衰竭临床观察;王笑梅等;《中国中医急症》;20071130;第16卷(第11期);第1328-1329页 * |
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