CN104857348A - Preparation method of medicine for treating early cirrhosis - Google Patents
Preparation method of medicine for treating early cirrhosis Download PDFInfo
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- CN104857348A CN104857348A CN201510291819.2A CN201510291819A CN104857348A CN 104857348 A CN104857348 A CN 104857348A CN 201510291819 A CN201510291819 A CN 201510291819A CN 104857348 A CN104857348 A CN 104857348A
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- grams
- herba
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- filtrate
- medicine
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- 239000003814 drug Substances 0.000 title claims abstract description 23
- 208000019425 cirrhosis of liver Diseases 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 206010016654 Fibrosis Diseases 0.000 title abstract description 3
- 230000007882 cirrhosis Effects 0.000 title abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000000706 filtrate Substances 0.000 claims abstract description 16
- 238000001914 filtration Methods 0.000 claims abstract description 11
- 239000000203 mixture Substances 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 3
- 241000628997 Flos Species 0.000 claims description 12
- 241000183291 Aleuritopteris Species 0.000 claims description 6
- 241001655769 Androsace Species 0.000 claims description 6
- 229940079593 drug Drugs 0.000 claims description 6
- 239000003826 tablet Substances 0.000 claims description 4
- 239000007919 dispersible tablet Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- 240000006248 Broussonetia kazinoki Species 0.000 abstract 1
- 235000006716 Broussonetia kazinoki Nutrition 0.000 abstract 1
- 241000525994 Calceolaria crenatiflora Species 0.000 abstract 1
- 241001148500 Ceratopteris thalictroides Species 0.000 abstract 1
- 241001148752 Diplazium Species 0.000 abstract 1
- 244000007485 Eragrostis pilosa Species 0.000 abstract 1
- 241000020101 Glossogyne tenuifolia Species 0.000 abstract 1
- 240000000084 Justicia gendarussa Species 0.000 abstract 1
- 241000612166 Lysimachia Species 0.000 abstract 1
- 241001006215 Lysimachia barystachys Species 0.000 abstract 1
- 241001459120 Musella lasiocarpa Species 0.000 abstract 1
- 240000003626 Ophiuros exaltatus Species 0.000 abstract 1
- 241001536527 Parnassia palustris Species 0.000 abstract 1
- 241001180927 Trigonotis peduncularis Species 0.000 abstract 1
- 241001561579 Ziziphora clinopodioides Species 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 description 8
- 230000003908 liver function Effects 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010019668 Hepatic fibrosis Diseases 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000003494 hepatocyte Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000003240 portal vein Anatomy 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method of a medicine for treating early cirrhosis. The prepration method comprises the following steps: taking the following raw materials: 80 grams of ceratopteris thalictroides, 70 grams of musella lasiocarpa, 70 grams of gramineae ophiuros exaltatus, 60 grams of lysimachia barystachys, 60 grams of gendarussa vulgaris, 60 grams of broussonetia kazinoki, 50 grams of eragrostis pilosa, 50 grams of lysimachia cletheroides, 50 grams of calceolaria crenatiflora, 30 grams of ziziphora clinopodioides, 30 grams of farinose twin-sorus fern herb, 30 grams of parnassia palustris, 30 grams of glossogyne tenuifolia, 20 grams of trigonotis peduncularis and 20 grams of radix glycyrrhizae; adding 9000 ml of water into the raw materials to obtain a mixture; heating the mixture I for 5 hours under reflux conditions, filtering the mixture I to obtain a filter residue 1 and a filtrate 1; adding 6000 ml of water into the filter residue 1 to obtain a mixture II; heating the mixture II for 3 hours under reflux conditions, filtering the mixture II to obtain a filter residue 2 and a filtrate 2; combining the filtrate 1 and the filtrate 2 to obtain the medicine.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of preparation method for the treatment of the medicine of early stage liver cirrhosis.
Background technology
Early stage liver cirrhosis refers to that liver parenchyma extensively destroys, Diffuse fibrous hypertrophy, is formed in regeneration in various degree and pseudolobuli by the hepatocyte separated.Now fibrous septum is roomy loose.Early stage liver cirrhosis be various chronic hepatopathy by the commitment of hepatic fibrosis to cirrhosis progress, therefore, early stage diagnosis and treatment, lapse to significant to patient's prognosis and the course of disease.
Summary of the invention
The object of this invention is to provide a kind of preparation method for the treatment of the medicine of early stage liver cirrhosis.
In order to realize object of the present invention, the invention provides a kind of preparation method for the treatment of the medicine of early stage liver cirrhosis, the method comprises the following steps: Herba pteridii latiusculi 80 grams of fetching water, Flos Musellae Lasiocarpae 70 grams, water hair penetrates 70 grams, XUEJINGCAO 60 grams, Herba Psychotriae Siamicae 60 grams, Folium et Cacumen Broussonetiae Kazinoki 60 grams, Herba Eragrostidis pilosae 50 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 50 grams, Flos clerodendri japonici 50 grams, lip Rhizoma et radix valerianae 30 grams, Aleuritopteris farinsa (Forsk.) Fee 30 grams, Herba parnassiae 30 grams, Herba bidentis parviflorae 30 grams, Herba Androsaces umbellatae 20 grams and 20 grams, Radix Glycyrrhizae, add 9000 milliliters, water, heating 5 hours under the condition of backflow, filter, obtain filtering residue 1 and filtrate 1, 6000 milliliters, water is added in described filtering residue 1, heating 3 hours under the condition of backflow, filter, obtain filtering residue 2 and filtrate 2, merge described filtrate 1 and described filtrate 2, obtain.
The present invention also provides the purposes of compositions in the medicine of preparation treatment early stage liver cirrhosis, and described medicine is made up by weight of following bulk drugs: Herba Ceratopteridis Thalictroidis 80 parts, Flos Musellae Lasiocarpae 70 parts, water hair penetrate 70 parts, XUEJINGCAO 60 parts, Herba Psychotriae Siamicae 60 parts, Folium et Cacumen Broussonetiae Kazinoki 60 parts, Herba Eragrostidis pilosae 50 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 50 parts, Flos clerodendri japonici 50 parts, lip Rhizoma et radix valerianae 30 parts, Aleuritopteris farinsa (Forsk.) Fee 30 parts, Herba parnassiae 30 parts, Herba bidentis parviflorae 30 parts, Herba Androsaces umbellatae 20 parts and 20 parts, Radix Glycyrrhizae.
Preferably, described medicine can make tablet, dispersible tablet, rapidly dissolving tablet, powder or decoction.
In the present compositions, Herba Ceratopteridis Thalictroidis, Flos Musellae Lasiocarpae are monarch drug, and water hair is penetrated, XUEJINGCAO, Herba Psychotriae Siamicae, Folium et Cacumen Broussonetiae Kazinoki, Herba Eragrostidis pilosae are ministerial drug, and Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Flos clerodendri japonici, lip Rhizoma et radix valerianae, Aleuritopteris farinsa (Forsk.) Fee, Herba parnassiae, Herba bidentis parviflorae, Herba Androsaces umbellatae are adjuvant drug, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Use natural drug in the medicine for the treatment of early stage liver cirrhosis of the present invention, therefore it has instant effect, good effect, the advantage that has no side effect.
Detailed description of the invention
Below by way of the description of detailed description of the invention, the invention will be further described, but this is not limitation of the present invention, those skilled in the art are according to basic thought of the present invention, various amendment or improvement can be made, but only otherwise depart from basic thought of the present invention, all within the scope of the present invention.
The preparation of embodiment decoction of the present invention
Water intaking Herba pteridii latiusculi 80 grams, Flos Musellae Lasiocarpae 70 grams, water hair penetrates 70 grams, XUEJINGCAO 60 grams, Herba Psychotriae Siamicae 60 grams, Folium et Cacumen Broussonetiae Kazinoki 60 grams, Herba Eragrostidis pilosae 50 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 50 grams, Flos clerodendri japonici 50 grams, lip Rhizoma et radix valerianae 30 grams, Aleuritopteris farinsa (Forsk.) Fee 30 grams, Herba parnassiae 30 grams, Herba bidentis parviflorae 30 grams, Herba Androsaces umbellatae 20 grams and 20 grams, Radix Glycyrrhizae, add 9000 milliliters, water, heating 5 hours under the condition of backflow, filter, obtain filtering residue 1 and filtrate 1, 6000 milliliters, water is added in described filtering residue 1, heating 3 hours under the condition of backflow, filter, obtain filtering residue 2 and filtrate 2, merge described filtrate 1 and described filtrate 2, obtain.
Experimental example
The diagnostic criteria of early stage liver cirrhosis:
1, liver function normally or may have mile abnormality; 2, liver fiber four checks that the overwhelming majority has obvious exception; 3, HBV-DNA checks there is virus replication; 4, liver ultrasound investigation: in liver, blood vessel display is unintelligible, and inner diameter of portal vein >=1.3cm, thickness of spleen is greater than 4.0cm, liver edge angle rust.
Selector close standard of stating early stage liver cirrhosis patient 90 example, wherein man 50 example, female 40 example, the oldest 61 years old, minimum 33 years old, 45 years old mean age.
Decoction obtained in embodiment is used to treat, wherein one day 2 times, oral 100 milliliters at every turn, treatment 3 months continuously.
Criterion of therapeutical effect
(1) effective: clinical symptoms disappears completely, liver spleen obviously bounces back or stablizes constant, and liver function recovery is normal, and drug withdrawal is not recurred in half a year;
(2) effective: clinical symptoms substantially disappears or alleviates, and liver spleen is stablized constant, and liver function is obviously improved, drug withdrawal occasionally has recurrence in half a year;
(3) invalid: before and after treatment, symptom, sign and liver function are all not improved or increase the weight of to worsen.
Result
Through treatment, find that the clinical symptoms of all patients disappears completely, liver spleen obviously bounces back or stablizes constant, and liver function recovery is normal, and drug withdrawal is not recurred in half a year, therefore all meets effective criterion of therapeutical effect.And do not find obvious untoward reaction over the course for the treatment of.
Claims (3)
1. treat the preparation method of the medicine of early stage liver cirrhosis for one kind, the method comprises the following steps: Herba pteridii latiusculi 80 grams of fetching water, Flos Musellae Lasiocarpae 70 grams, water hair penetrates 70 grams, XUEJINGCAO 60 grams, Herba Psychotriae Siamicae 60 grams, Folium et Cacumen Broussonetiae Kazinoki 60 grams, Herba Eragrostidis pilosae 50 grams, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 50 grams, Flos clerodendri japonici 50 grams, lip Rhizoma et radix valerianae 30 grams, Aleuritopteris farinsa (Forsk.) Fee 30 grams, Herba parnassiae 30 grams, Herba bidentis parviflorae 30 grams, Herba Androsaces umbellatae 20 grams and 20 grams, Radix Glycyrrhizae, add 9000 milliliters, water, heating 5 hours under the condition of backflow, filter, obtain filtering residue 1 and filtrate 1, 6000 milliliters, water is added in described filtering residue 1, heating 3 hours under the condition of backflow, filter, obtain filtering residue 2 and filtrate 2, merge described filtrate 1 and described filtrate 2, obtain.
2. the purposes of compositions in the medicine of preparation treatment early stage liver cirrhosis, it is characterized in that, described medicine is made up by weight of following bulk drugs: Herba Ceratopteridis Thalictroidis 80 parts, Flos Musellae Lasiocarpae 70 parts, water hair penetrate 70 parts, XUEJINGCAO 60 parts, Herba Psychotriae Siamicae 60 parts, Folium et Cacumen Broussonetiae Kazinoki 60 parts, Herba Eragrostidis pilosae 50 parts, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 50 parts, Flos clerodendri japonici 50 parts, lip Rhizoma et radix valerianae 30 parts, Aleuritopteris farinsa (Forsk.) Fee 30 parts, Herba parnassiae 30 parts, Herba bidentis parviflorae 30 parts, Herba Androsaces umbellatae 20 parts and 20 parts, Radix Glycyrrhizae.
3. purposes according to claim 2, is characterized in that, described medicine can make tablet, dispersible tablet, rapidly dissolving tablet, powder or decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510291819.2A CN104857348B (en) | 2015-06-01 | 2015-06-01 | A kind of preparation method for the treatment of the medicine of early stage liver cirrhosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510291819.2A CN104857348B (en) | 2015-06-01 | 2015-06-01 | A kind of preparation method for the treatment of the medicine of early stage liver cirrhosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104857348A true CN104857348A (en) | 2015-08-26 |
| CN104857348B CN104857348B (en) | 2016-03-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510291819.2A Expired - Fee Related CN104857348B (en) | 2015-06-01 | 2015-06-01 | A kind of preparation method for the treatment of the medicine of early stage liver cirrhosis |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117064962A (en) * | 2023-10-17 | 2023-11-17 | 中山大学附属第七医院(深圳) | Tung or extract thereof, composition thereof and use thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586611A (en) * | 2004-09-23 | 2005-03-02 | 内蒙古伊泰医药科技开发有限责任公司 | Preparation of granular powder for treating hepatitis and quality control method |
| CN103055285A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof |
-
2015
- 2015-06-01 CN CN201510291819.2A patent/CN104857348B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1586611A (en) * | 2004-09-23 | 2005-03-02 | 内蒙古伊泰医药科技开发有限责任公司 | Preparation of granular powder for treating hepatitis and quality control method |
| CN103055285A (en) * | 2012-12-26 | 2013-04-24 | 柳州市中医院 | Traditional Chinese medicine for treating forepart hepetocirrhosis and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 孟庆芳等: "中成药为主治疗早期肝硬化疗效分析", 《实用中医药杂志》 * |
| 朱丽芳: "名老中医治疗早期肝硬化的经验", 《四川中医》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117064962A (en) * | 2023-10-17 | 2023-11-17 | 中山大学附属第七医院(深圳) | Tung or extract thereof, composition thereof and use thereof |
| CN117064962B (en) * | 2023-10-17 | 2024-02-09 | 中山大学附属第七医院(深圳) | Tung or extract thereof, composition thereof and use thereof |
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| Publication number | Publication date |
|---|---|
| CN104857348B (en) | 2016-03-02 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Address after: 210000 No. 29, Hankou Road, Gulou District, Jiangsu, Nanjing Applicant after: Zhu Xuzhen Address before: 225127 Jiangsu city of Yangzhou Province Yang Road No. 18 Applicant before: Zhu Xuzhen |
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Free format text: CORRECT: ADDRESS; FROM: 225127 YANGZHOU, JIANGSU PROVINCE TO: 210000 NANJING, JIANGSU PROVINCE |
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| EXSB | Decision made by sipo to initiate substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Wei Inventor after: Ma Baofeng Inventor after: Wang Chaohui Inventor before: Zhu Xuzhen |
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| COR | Change of bibliographic data | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20160118 Address after: 266000 Shandong Province, Qingdao city Jingde Road No. 17, building 9, unit 1, Room 501 Applicant after: Li Wei Address before: 210000 No. 29, Hankou Road, Gulou District, Jiangsu, Nanjing Applicant before: Zhu Xuzhen |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160302 Termination date: 20180601 |
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| CF01 | Termination of patent right due to non-payment of annual fee |