CN104840883B - Treat the Chinese medicine of cirrhosis patients in decompensation - Google Patents

Abstract

The invention discloses a kind of Chinese medicine for treating cirrhosis patients in decompensation, and in units of parts by weight, the bulk drug that its active ingredient is made is：Radix Angelicae Sinensis l0~20 part, 10~15 parts of the root of herbaceous peony, 10~15 parts of rhizoma atractylodis macrocephalae, 20~25 parts of Poria cocos, 6~10 parts of radix bupleuri, 10~15 parts of rhizoma cyperi, 8~10 parts of root tuber of aromatic turmeric, 15~20 parts of Carapax Trionycis (processed), 8~10 parts of pangolin, 10~15 parts of matrimony vine, 12~15 parts of sealwort, 15~20 parts of rhizoma alismatis, 10~15 parts of umbellate pore furgus, 15~20 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, 3~5 parts of radix glycyrrhizae, 30~35 parts of corn stigma, 25~30 parts of radish seed, 30~32 parts of radix pseudostellariae, 13~15 parts of Buddhist nunnery gate of a village, 25~30 parts of Paper mulberry Fruit, 15~18 parts of Sichuan Herba Dendrobii.The present invention can be cleared liver with dispersing stagnated hepatoqi, the dampness elimination of fortune spleen, clearing damp and promoting diuresis, yin-nourishing, had obvious therapeutic effect to cirrhosis patients in decompensation syndrome of blockade of dampness due to qi stagnation, also alcoholic cirrhosis can be made to recover to normal.The present invention has no toxic side effect, total effective rate 92.85%, is the choice drug of cirrhosis patients in decompensation patient.

Description

Treat the Chinese medicine of cirrhosis patients in decompensation

Technical field：

The present invention relates to a kind of liver that can effectively treat and be triggered by hepatitis B, hepatitis C, alcoholic liver and fatty liver The Chinese medicine of Decompensated stage is hardened, belongs to technical field of traditional Chinese medicines.

Background technology：

Cirrhosis patients in decompensation is exactly the Symptoms in hepatic sclerosis late period, refers generally to cirrhosis progress to a certain extent, is surpassed Go out the compensatory capacity of liver function, clinic has obvious pathological change.Be mainly shown as hepatic disorder, have portal hypertension, splenomegaly, Ascites, hepatic encephalopathy or UGB, this period are called cirrhosis patients in decompensation.

First, hepatocirrhosis symptoms are summarized：

Different pathological stages is in, the Symptoms of liver cirrhosis patient can also have differences, such as Decompensated liver cirrhosis Phase Symptoms are different from the performance of hepatic sclerosis early symptom, and this difference can be symptom difference or show light Weight degree is different.

1st, constitutional symptom shows：

Liver cirrhosis patient poor appetite, Body weight loss, sleepy weak symptom are more obvious, and severe patient even lies in bed not Rise, can't take care of oneself.Cutaneous manifestations it is withered coarse, complexion is gloomy pitch-dark, and body has anaemia, glossitis, angular stomatitis, night The Symptoms such as blind, polyneuritis and edema.

2nd, endocrinopathy：

Endocrinopathy is that estrogen, aldosterone and antidiuretic hormone increase in cirrhosis patients in decompensation Symptoms, female Occurs dysequilibrium between sex hormone and male sex hormone, male patient often has mammary development, sexual hypoesthesia, orchiatrophy, hair Come off；Female patient has irregular menstruation, amenorrhoea etc..

3rd, symptom of digestive tract shows：

The illnesss such as stomach extravasated blood make its digestion, absorption function obstacle occur, cause patient's appetite substantially to decline, several after feed Minute will feel epigastric discomfort and glutted, appearance nausea or even vomit, and to fat and protein poor resistance, enter greasy food Easily cause fatty diarrhea.

2nd, the cause of disease：

Cause that the cause of disease of hepatic sclerosis is a lot, and China is most commonly seen with virus hepatitis, it is external then in the majority with alcoholism.

1st, virus hepatitis：Predominantly virus B hepatitis, it is secondly the third type or B-mode plus fourth type superinfection and penta Type does not develop into hepatic sclerosis typically.

2nd, Japanese schistosomiasis：China Schistosomiasis in Yangtze River Valley Endemic Area is common.Repeatedly or Long-term Infection snail fever Person, worm's ovum and its toxic product stimulate connective tissue proliferation in liver portal area, cause liver fibrosis and portal hypertension, referred to as blood Fluke characteristic of disease fibrosis.

3rd, alcoholism：Long-term heavy drinker, alcohol and its mesostate（Acetaldehyde）Directly damage liver cell, drop The low resistance to some toxicants, the long-term nutrition imbalance caused by indulging in excessive drinking also play certain detrimental effect to liver.

4th, medicine or chemical toxicant：Long-term use of some drugses such as diacetyl diphenolisatin, ethyldopa etc. can cause Poisoning liver Inflammation, finally develop into hepatic sclerosis.

5th, cholestasis：When extrahepatic bile ducts obstruction or the alluvial of liver inner bag persistently be present, the bile acid and bilirubin of high concentration There is detrimental effect to liver cell, degeneration of liver cells necrosis, proliferation of fibrous tissue, cause hepatic sclerosis.

6th, chronic congestive heart failure, constrictive pericarditis, vena hepatica or inferior vena cava obstruction etc. make liver become silted up for a long time Blood, liver cell anoxic, necrosis and connective tissue proliferation, finally develops into hepatic sclerosis.

One of the above or Different types of etiopathogenises long term can cause degeneration of liver cells downright bad in liver, and regenerated nodule is formed, Diffusivity connective tissue proliferation, pseudolobuli are formed.

3rd, sign：

1st, hepatic face：Have a dark complexion, have sunken cheeks, the hepatic face that cheekbone protrudes, or even in bronze-colored, complexion change Degree it is parallel with dyshepatia degree, then indicate prognosis bona in bronze-colored face

2nd, spider angioma and telangiectasis：Spider angioma differs in size, and is distributed mainly in the region of superior vena cava drainage, With face, neck, and upper breast are common, the shoulder back of the body, rare below nipple, unclear the reason for this regularity of distribution.

3rd, liver tongue：Early-phase hepatocirrhosis may occur in which the house congested change of edge rete vasculosum, lingual surface after hepatic sclerosis further develops In the red or reddish blue of paint, congested swelling, smooth few tongue or without tongue, shape such as cow tongue.

4th, jaundice；About half patient has a jaundice, light and heavy degree, general how less serious.

5th, xanthoma：The patient of biliary cirrhosis is visible, is nodositas or flat, is more common in eyelid, inside and outside to adjoin Or at extremities joint stretching, extension, it is more simultaneously with pruitus.

6th, liver palms：Liver palms is confined to the cerise change with finger base portion between the big hypothenar of facies palmaris.

7th, hepatomegaly：The size of liver has relation with the course of disease, the cause of disease and pathological change, and is comprehensive function result.

8th, endocrinopathy：Male shows as orchiatrophy, trichomadesis, proliferation of mammary gland etc..Some patient's adrenal gland skins Matter hormone secretion is reduced, therefore pigmentation occurs at face, neck upper limbs and mucous membrane, there is certain specificity.

4th, clinical manifestation：

Hemorrhagic tendency：Such as nosebleed, there is blutpunkte or ecchymosis in bleeding gums when brushing teeth, skin, or even forms hemotoncus, Blood coagulation system can be caused obstacle occur.

Chronic liver disease face：It is show as that xerosis cutis, complexion are gloomy pitch-dark more, the facial and other exposed portion of some patientss The skin of position also may occur in which pigmentation, and the pigmentation especially around eye socket becomes apparent.

UGB：This is the common syndrome of cirrhosis patients in decompensation patient's table, and has the higher death rate. Cause esophageal varix mainly due to portal hypertension, vascular wall is thinning, very easily rupturable to cause massive haemorrhage.Hepatic sclerosis loses generation The phase UGB of repaying often breaks with tremendous force, and bleeding is anxious and more and is not easy to stop.If having little time to rescue, normal threat to life, very More patients die from massive haemorrhage first.

Liver ascites：Liver ascites is the most common complication of cirrhosis patients in decompensation.Once liver ascites occur represents hepatic sclerosis Enter the Decompensated stage stage.In general liver ascites volume is bigger, and the number of occurrence is more, more bad.So there is liver abdomen Water person should timely and effectively be treated.

Endocrinopathy：Hepatic sclerosis has arrived Decompensated stage, and the function of liver just fails more obvious so that female in vivo The inactivation of hormone is largely reduced, and female hormone secretory volume will increase, and phenomena such as be suppressed with male sex hormone.

5th, cirrhosis patients in decompensation symptoms：

1st, whole body cirrhosis patients in decompensation symptom：

Become thin weak, lassitude, cirrhosis patients in decompensation severe person is weak and is unable to leave the bed.Xerosis cutis are coarse, face Color is gloomy pitch-dark.Often there is the cirrhosis patients in decompensation symptom such as anaemia, glossitis, angular stomatitis, yctalopia, polyneuritis and edema. Cirrhosis patients in decompensation can have irregular low-heat, and possible cause is necrosis of liver cells, liver detoxification function decline intestinal absorption Toxin enters the cirrhosis patients in decompensation reason such as body circulation, portal vein thrombosis or intimitis, secondary infection and caused.

2nd, alimentary canal cirrhosis patients in decompensation symptom：

Appetite substantially declines, and i.e. sense epigastric discomfort and glutted after feed, nausea, even vomits, cirrhosis patients in decompensation pair Fat and protein poor resistance, enter greasy food, easily cause diarrhoea.Cirrhosis patients in decompensation patient is because of ascites and gastrointestinal pneumatosis And feel abdominal distension unbearably, late period may occur in which Poisoning intestinal tympanites.Cirrhosis patients in decompensation patients more than half have slight jaundice, a small number of livers Hardening Decompensated stage patient has moderate or severe jaundice, and the latter prompts liver cell to have progressive or extensive necrosis.

3rd, hemorrhagic tendency and anaemia cirrhosis patients in decompensation symptom：

Cirrhosis patients in decompensation symptom osler disease, gingiva bleeding gingival hemorrhage, skin ecchymosis and gastrointestinal mucosa erosion bleeding etc..Liver is hard Changing Decompensated stage patient still has different degrees of anaemia, more low by nutritional deficiency, intestinal absorption ability, Hypersplenism and stomach and intestine The road factor such as lose blood causes.

4th, endocrinopathy cirrhosis patients in decompensation symptom：

Endocrine disturbance has estrogen, aldosterone and antidiuretic hormone to increase.The cirrhosis patients in decompensation symptom main cause liver Hypofunction weakens to its deactivation, and excretion increases in accumulating, urinating in vivo；Cirrhosis patients in decompensation estrogen increases When, anterior pituitary function is suppressed by feedback mechanism, so as to influence the machine of the gonad axis of hypophysis one and the adrenal cortex axle of hypophysis one Can, cause male sex hormone to reduce, cortex hormone of aadrenaline is also reduced sometimes.

5th, spider angioma, liver palm are the symptoms for the hepatic sclerosis for being easier discovery：

The skin parteriole of some expansions, surrounding can occur in face, neck, chest, shoulder, forearm and the back of the hand etc. in general patient The tiny branch of branch sample of oriented surrounding radiation, form picture small spider one by one, in cerise, with nib, pin or thin rod The central point of mole is oppressed in one end, mole and its peripheral ramifications can be made to disappear, here it is spider angioma.

6th, check：

Cirrhosis patients in decompensation is because be diagnosed as hepatic sclerosis late period, it is only necessary to it is unconventional to do some when being necessary Check, such as liver puncture inspection, the serology etc. of 4 fibrosis, but some routine inspections still have to do.

7th, conventional project inspection：

Imageological examination：B ultrasound, CT and Magnetic resonance imaging etc. can be found that some signs of liver fibrosis, and ultrasound diagnosis is The reference of degree of cirrhosis is assessed during early-phase hepatocirrhosis, it can be found that the liver rough surface of patient is uneven, the display of liver echo strengthens, The symptoms such as hepatomegaly, thickening, Hepatic contrast CT scan can also be done again by pinpointing the problems, and improve the accuracy rate of diagnosis.

Liver function test：Measure including haemocyanin, show as albumin reduction, globulin rise, albumin and ball The ratio of albumen is inverted.Protein electrophoresis displays that albumin reduction, and gamma Globulin increases.Determination of bilirubin is in liver function decompensation Phase, serum total bilirubin and bilirubin direct can have different degrees of rise.Serum glutamic pyruvic transminase is shown in serum enzyme inspection (ALT) it can be raised with glutamic-oxalacetic transaminease (AsT), reflect the degree of hepatocellular damage；Monoamine oxidase (MAO) and collagenic supersession Relevant, its activity can reflect fibrosis formation and active level, and (MAO) can rise when being formed in liver if any obvious fibrosis It is high；Gamma glutamyl transpeptidase：γ-GT are raised when liver function Decompensated stage or liver fibrosis, are had simultaneously when γ-GT are significantly raised Send out the possibility of liver cancer.

Procollagen III peptid (P of P III) determines：The index of diagnosing liver fibrosis, normal value is 0.46 ± O.11 μ/ ml。

Prothrombin time (PT)：Liver function Decompensated stage PT extends.

Immunologic test：IgG, IgA, IgM are raised, and are raised with IgG most obvious.The cause of disease is virus hepatitis person, can do second Liver five, antibody to hepatitis C etc. check.

Ascites inspection：Cirrhotic ascites is faint yellow omission timber, and transparency reduces if scabies secondary infection, and leucocyte increases, Bacteria Culture can be positive.Bloody ascites is often prompted to merge liver cancer.

Blood routine and routine urianlysis：How normal blood routine is in the liver function compensatory phase, Decompensated stage leucocyte and blood platelet Reduce, routine urianlysis shows Decompensated stage visible albumen, cast in urinating sometimes.

Aetology：Including double of hepatitis B antigen antibody two and HBV-DNA.The HbsAg positives are the marks of HBVer, such as HbsAg is negative and HbsAb is positive, then has and resist hepatitis B infected ability.This is also the laboratory examination of hepatic sclerosis.

Fat metabolism：Compensatory phase patient blood cholesterol is normal or relatively low, Decompensated stage T-CHOL particularly cholesterol Ester substantially reduces.

B ultrasound：In the clinical examination of hepatic sclerosis, ultrasound diagnosis is indispensable, by ultrasound diagnosis it will be seen that liver Profile variation, liver position change, Glisson's capsule, corner change, liver parenchyma change, Vascular change etc. inside and outside liver.

When hepatic sclerosis does ultrasound diagnosis, liver position change shows as the upper and lower footpath of right lobe of liver and shortened, and rib asks the narrowed thickness right side Clino-diagonal is not easy to measure under rib.Left lobe of liver Compensatory hypertrophy, right side anterior axillary line is caused to be raised compared with normal position.

When hepatic sclerosis does ultrasound diagnosis, echo is fine and close in liver parenchyma change performance liver parenchyma, the enhancing of echo diffusivity, thickening； Change or in rope strip, nodal-like for the uneven diffusivity plaque-like of reflection in the visible liver parenchyma of major tubercle hepatic sclerosis B ultrasound result Light belt, light blob change, and sound transparency is poor, the visible small low echo area between strong echo.

Glisson's capsule, corner change, ultrasound diagnosis show as Glisson's capsule and thickened during hepatic sclerosis, lose smooth fiber bright line and return Sound strengthens, became uneven, liver edge angle rust or irregular.

8th, complication：

Infection：Hepatic sclerosis easily concurrent various infection such as bronchitis, pneumonia, tubercular peritonitis, infection of biliary tract, enteron aisle sense Dye, spontaneous peritonitis and gram-Negative bacillus septicemia etc..Various viruses are infected, injury, people constantly are produced to human body Resistivity also can further decline, and then cause human body constantly to weaken.

UGB：It is common with Bleeding of Esophageal Gastric Varices, other causes of bleeding such as acute hemorrhagic Erosive gastritis, Mallory-Weiss Syndrome etc..General bleeding can all trigger sanguinariness, until dead.

Hepatic encephalopathy (hepatic coma)：It is the most common cause of death of liver cirrhosis patient.What this cirrhotic complications occurred Reason is often that patient is excessively caused to the intake of protein.So the nursing key to this kind of patient is exactly to control albumen The matter amount of eating, reduce ammonia concentration.Patient need to take in protein in right amount in life, the high fresh water of more edible Multivitamin contents Fruit and vegetable, and the diet principle of a small amount of more meal is followed, keep the unobstructed of stool.

Hepatorenal syndrome：Hepatic sclerosis merges intractable ascites duration length, or concurrent infection, original hepatopathy aggravates etc. because Element, there is oliguresis, anuria, azotemia, low blood sodium, hyponatruria, initial kidney is often without organic disease, so referred to as function Property renal failure.

Portal vein thrombosis：Its reason mainly causes portal venous flow slow with pylemphraxis, and in portal vein Film is scorching, hardening is relevant.There is tormina, abdominal distension, vomits, has blood in stool, performance of suffering a shock suddenly in such as patient with liver cirrhosis, then is considered as Portal vein thrombosis.In addition, spleen often increases rapidly, ascites accelerates to be formed, and often induces hepatic encephalopathy.

Primary carcinoma of liver：Hepatic sclerosis and Relations with Liver Cancer attract people's attention, thus it is speculated that its mechanism is probably that hepatitis B causes liver thin Born of the same parents damage and secondary hyperplasia or atypical hyperplasia, and the integration of hepatitis B and liver cell and the hard patient's immunologic function of liver change The factors such as change are relevant.

Ascites：There are a small amount of liquid, about 50ml in normal person abdominal cavity, be referred to as ascites, ascites when amount of liquid is more than 200ml For the common complication of decompensated liver cirrhosis.

Respiratory system damages：Various lungs change caused by liver diseases is referred to as hepatopulmonary syndrome by some scholars, Its essence is pulmonary vascular expansion and arterial oxygenation exception occur during hepatopathy, hypoxemia can be caused.

9th, diet care：

The patient of cirrhosis patients in decompensation is it is noted that have many meals but little food at eath, never eat and drink immoderately, in order to avoid increase liver and intestines and stomach Burden, and then aggravated the state of an illness；It is preferred with high protein homovitamin, low fat, high-energy, low cholesterol, holds light diet It is advisable.

Liver cirrhosis patient preferably eats homovitamin, low fat, high protein, digestible thing food, such as egg, vegetables, lean meat, fish Etc.；The concurrent hepatic coma person of end-age cirrhosis, should ensure that low protein diet.Edema is heavier or has ascites to lack salt or salt-free drink Food, constipation can eat sesame oil, honey, sesame, banana etc. more, can keep free movement of the bowels, and the accumulation for reducing ammonia prevents liver Stupor.

End-age cirrhosis patient diet can improve patient's appetite, in time supplement patient's machine it is noted that various and equalization Needed for body, the enhancing of reparation, system to Patients ' Hepatocytes, prevention malnutrition etc. are all helpful；Patient will avoid pungent Peppery irritable food, which is avoided, drinks, and alcohol metabolism product can directly poison the liver being badly damaged, and induces abnormal liver function and accelerates Destruction and necrosis of liver etc., therefore hepatopath should be advisable on diet away from tobacco and wine, with light diet.

Tenth, points for attention：

1st, the careful amount of protein diet.Although emphasizing that patient need to enter high-protein diet, there is hepatic encephalopathy person to answer low albumen to drink Food.

2nd, careful amount is fed.Food-intake is satisfied with eighty per cant to be preferred, and is sure not excess, not feel that abdominal distension as degree, has postprandial after feed Abdominal distension person, front and rear soup amount of having meal should be reduced.

3rd, suit the medicine to the illness.What food variety should reduce protein based on light food, during jaundice takes the photograph people, disappears again etc. jaundice Gradually increase protein intake, in order to avoid inducing cholecystitis breaking-out, aggravate jaundice or make jaundice be not easy to disappear.

4th, avoid on an empty stomach.The available food of diet of hepatic sclerosis is fish, green vegetables, bean sprouts, bean product etc., fruit with orange, Apple is preferable, but it is noted that not feed fruit on an empty stomach,

5th, it is hygienic.Hepatic sclerosis conditioning during, all foods all should fresh clean, in order to avoid because resistance decline, there is abdomen The enteric infection performance such as rush down and aggravate the state of an illness.

6th, avoid coarse.The dietetic food of hepatic sclerosis should not be excessively coarse, in order to avoid induce varicose esophageal vein Rupture haemorrhag.

The content of the invention：

The technical problems to be solved by the invention are：The treatment hepatic sclerosis that a kind of effect is good, has no toxic side effect is provided and loses generation The Chinese medicine of phase is repaid, can effectively treat the cirrhosis patients in decompensation disease triggered by hepatitis B, hepatitis C, alcoholic liver and fatty liver Disease.

It is of the invention to be for the technical solution adopted for solving the technical problem：

A kind of Chinese medicine for treating cirrhosis patients in decompensation, in units of parts by weight, the bulk drug that its active ingredient is made is： Radix Angelicae Sinensis l0~20 part, 10~15 parts of the root of herbaceous peony, 10~15 parts of rhizoma atractylodis macrocephalae, 20~25 parts of Poria cocos, 6~10 parts of radix bupleuri, rhizoma cyperi 10~15 Part, 8~10 parts of root tuber of aromatic turmeric, 15~20 parts of Carapax Trionycis (processed), 8~10 parts of pangolin, 10~15 parts of matrimony vine, 12~15 parts of sealwort, rhizoma alismatis 15 ~20 parts, 10~15 parts of umbellate pore furgus, 15~20 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, 3~5 parts of radix glycyrrhizae, 30~35 parts of corn stigma, 25~30 parts of radish seed, 30~32 parts of radix pseudostellariae, 13~15 parts of Buddhist nunnery gate of a village, 25~30 parts of Paper mulberry Fruit, 15~18 parts of Sichuan Herba Dendrobii.

The Chinese medicine of described treatment cirrhosis patients in decompensation, in units of parts by weight, the bulk drug of its active ingredient is made For：Radix Angelicae Sinensis l0 parts, 10 parts of the root of herbaceous peony, 10 parts of rhizoma atractylodis macrocephalae, 20 parts of Poria cocos, 6 parts of radix bupleuri, 10 parts of rhizoma cyperi, 10 parts of root tuber of aromatic turmeric, Carapax Trionycis (processed) 15 Part, 8 parts of pangolin, 15 parts of matrimony vine, 15 parts of sealwort, 15 parts of rhizoma alismatis, 10 parts of umbellate pore furgus, 15 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, 3 parts of radix glycyrrhizae, corn stigma 35 Part, 30 parts of radish seed, 30 parts of radix pseudostellariae, 15 parts of Buddhist nunnery gate of a village, 30 parts of Paper mulberry Fruit, 15 parts of Sichuan Herba Dendrobii.

The pharmaceutical dosage form of the Chinese medicine of the treatment cirrhosis patients in decompensation is soft capsule preparation.

The preparation method of the Chinese medicine of above-mentioned treatment cirrhosis patients in decompensation is：

1. into above-mentioned 21 taste Chinese medicine plus 6 times of amount water, immersion 30 minutes, heating decoct 2 hours；2nd time plus 4 times amount water, Decoct 1.5 hours；3rd time plus 2 times amount water, is decocted 45 minutes.Merge 3 decoction liquors, stand 12 hours, supernatant crosses 200 mesh Sieve, filtrate are stand-by.

2. filtrate decompression is concentrated by evaporation to paste, stop heating, 2 times of 75% ethanols of amount added into thick paste, are stirred evenly, Stand overnight, supernatant liquid filtering, filtrate is stand-by.

3. filtrate adds appropriate refining of edible vegetable oil or cod-liver oil (sloughing hard fat in 0 degrees centigrade) to dissolve, and Adjustment concentration to every ball should be more than the 85.0% of expression amount containing traditional Chinese medicine ingredients, stand-by as decoction.

4. separately taking glycerine and water to be heated to 70~80 degrees Celsius, gelatin is added, stirring is dissolved, and is incubated 1~2h, is removed and is floated Foam, filter (maintenance temperature), add pill carry out dripping, using atoleine as coolant, collect the capsule and pill of condensation, Wipe the coolant sticked away with gauze, blow a cold wind over 4h at room temperature, is put under 25~35 degrees Celsius and dries 4h, then through petroleum ether 2 times, 3~5 minutes every time, the atoleine of capsule and pill outer layer is removed, then washed once with 95% ethanol, it is finally Celsius 30~35 Degree drying about 2 hours, screening, quality inspection, packaging, is produced.

In the present invention, the pharmacological action of each bulk drug is as follows：

1st, Radix Angelicae Sinensis：

Meridian distribution of property and flavor：Sweet, acrid, warm.Return liver, the heart, the spleen channel.

Effect：Promoting blood circulation and stopping pain, tonifying blood and regulating menstruation, relax bowel.

Cure mainly：For dizziness due to deficiency of blood, irregular menstruation, Amenorrhea, dysmenorrhoea, sallow complexion, asthenia cold abdominalgia, traumatic injury, rheumatism Numbness pain, ulcer sores, dry constipation of intestines.

2nd, the root of herbaceous peony：

Meridian distribution of property and flavor：Bitter, acid, is slightly cold.Return liver, the spleen channel.

Effect：The moon, soft liver analgesic, suppressing liver-YANG are held back in blood-nourishing.

Cure mainly：For irregular menstruation, uterine bleeding, abnormal sweating, gastral cavity abdomen shoot, pain over the hypochondriac region, four limbs contraction pain, dizziness of having a headache.

3rd, rhizoma atractylodis macrocephalae：

Meridian distribution of property and flavor：It is bitter, sweet, temperature；Returns spleen, stomach.

Effect：Air making-up and spleen enlivening, eliminate dampness and have diuretic effect, hidroschesis are antiabortive.

Cure mainly：For deficiency-weakness of spleen-QI, anorexia and loose stool, phlegm and retained fluid oedema, exterior deficiency spontaneous perspiration, fetal irritability.

4th, Poria cocos：

Meridian distribution of property and flavor：It is sweet, light, put down.The thoughts of returning home, spleen, kidney channel.

Effect：Clearing damp and promoting diuresis, invigorating the spleen, calm the nerves.

Cure mainly：For oedema, diarrhea, difficult urination, phlegm and retained fluid, palpitaition, insomnia.

5th, radix bupleuri：

Meridian distribution of property and flavor：It is bitter, pungent, be slightly cold.Thoughts of returning home envelope, liver, courage, tri-jiao channel.

Effect：Evacuation is brought down a fever, soothing liver-qi stagnation, is risen and is lifted yang-energy.

Cure mainly：For cold, fever, fevers and chills alternate, the distending pain in hypochondrium, irregular menstruation, prolapse of the anus, the prolapse of uterus.

6th, rhizoma cyperi：

Meridian distribution of property and flavor：Pungent, slight bitter, micro-sweet, put down.Return liver, spleen, tri-jiao channel.

Effect：Soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, menstruction regulating and pain relieving.

Cure mainly：For stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is vexed, turgor pain Bitterly, irregular menstruation, closed dysmenorrhea.Pungent, slight bitter, micro-sweet, put down.

7th, root tuber of aromatic turmeric：

Meridian distribution of property and flavor：It is pungent, bitter, tremble with fear.The thoughts of returning home, liver, gallbladder channel.

Effect：Promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, clearing heat and cooling blood, waking up the patient from unconsciousness by clearing away heart fire, removing dampness through diuresis and removing jaundice.

Cure mainly：For pain in chest and hypochondrium, irregular menstruation , abdominal lump of mass in abdomen, spit blood, bleeding from five sense organs or subcutaneous tissue, women's vicarious menstruation, warm disease coma, phlegm heat Epilepsy, warm jaundice.

8th, Carapax Trionycis (processed)：

Meridian distribution of property and flavor：It is salty, tremble with fear.Return liver warp.

Effect：Nourishing and suppressing Yang, softening and resolving hard mass.

Cure mainly：For consumption of YIN caused by febrile disease, endogenous deficient wind and in fever due to yin deficiency.It is used for chronic malaria, malaria mother, Amenorrhea, Disorder lumps in the abdomen again.

9th, pangolin：

Meridian distribution of property and flavor：It is salty, it is slightly cold.Return liver, stomach.

Effect：Invigorate blood circulation, lower breast, detumescence and apocenosis.

Cure mainly：For Amenorrhea , Disorder lumps in the abdomen, alactation, arthralgia pain due to rheumatism, spasm of limbs, carbuncle swells, scrofula subcutaneous nodule.

10th, matrimony vine：

Meridian distribution of property and flavor：It is sweet, put down.Return liver, kidney, lung channel.

Effect：It is nourishing liver and kidney, improving eyesight, moistening lung.

Cure mainly：For the deficiency of liver-yin and kidney-yin, have a dizzy spell, hypopsia, soreness and weakness of waist and knees, seminal emission is quenched one's thirst and deficiency of Yin overstrain cough.

11st, sealwort：

Meridian distribution of property and flavor：It is sweet, it is mild-natured.Returns spleen, lung, kidney channel.

Effect：Boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing.

Cure mainly：For deficiency of spleen-QI and stomach-QI, fatigue and asthenia, deficiency of stomach-Yin, dry deficiency of food, deficiency syndrome of the lung cough caused by dryness, overstrain cough hemoptysis, essence and blood is not Foot, soreness and weakness of waist and knees, poliosis, Heat Diabetes.

12nd, rhizoma alismatis：

Meridian distribution of property and flavor：It is sweet, light, tremble with fear.Return kidney, bladder warp.

Effect：Clearing damp and promoting diuresis, expel the heat-evil.

Cure mainly：For difficult urination, oedema, diarrhea, stranguria with turbid discharge, with.

13rd, umbellate pore furgus：

Meridian distribution of property and flavor：It is sweet, light, put down.Enter the heart, spleen, stomach, lung, kidney, warp.

Effect：Clearing damp and promoting diuresis.

Cure mainly：For difficult urination, oedema, diarrhea.

14th, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA：

Meridian distribution of property and flavor：It is sweet, salty, tremble with fear.Return liver, kidney, the heart channel of Hang-Shaoyin.

Effect：Nourishing and suppressing Yang, replenishing kidney and strengthening bone, blood-nourishing bushing.

Cure mainly：For having a dizzy spell, hectic fever due to yin labor heat, soreness and weakness of waist and knees, insomnia of palpitating with fear.

15th, radix glycyrrhizae：

Meridian distribution of property and flavor：It is sweet, put down.The thoughts of returning home, spleen, lung, stomach.

Effect：Invigorate the spleen and benefit qi, moisten the lung and relieve the cough, it is clearing heat and detoxicating, alleviate analgesic, relax the property of medicine.

Cure mainly：For weakness of the spleen and the stomach, shortness of breath and fatigue, palpitation and severe palpitation, cough phlegm is few, pathopyretic ulcer, medicine food poisoning, and gastral cavity abdomen is anxious Bitterly, four limbs contraction pain.

16th, corn stigma：

Meridian distribution of property and flavor：It is sweet, light, flat, return bladder, liver, gallbladder channel.

Effect：Inducing diuresis to remove edema, removing dampness through diuresis and removing jaundice.

Cure mainly：For oedema, dribbling urination, jaundice, cholecystitis, gall stone, high blood pressure, diabetes, alactation.

17th, radish seed：

Meridian distribution of property and flavor：It is pungent, sweet, put down.Return lung, spleen, stomach.

Effect：Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.

Cure mainly：For retention of food and drink, abdominal distention, constipation, stagnate rush down dysentery, and phlegm, which is stopped up, breathes with cough.

18th, radix pseudostellariae：

Meridian distribution of property and flavor：It is sweet, slight bitter, put down.Returns spleen, lung channel.

Effect：Tonifying Qi is promoted the production of body fluid.

Cure mainly：Thirsty for deficiency of food, cough caused by dryness phlegm is few.

19th, Buddhist nunnery gate of a village：

Meridian distribution of property and flavor：Warm-natured acrid flavour, hardship.Enter meridian of Foot-JUE YIN.

Effect：The row stasis of blood, clearing damp.

Cure mainly：For women's blood stasis, postpartum stops stasis of blood stomachache, traumatic injury, arthralgia pain due to rheumatism.

20th, Paper mulberry Fruit：

Meridian distribution of property and flavor：It is sweet, tremble with fear.Enter liver, spleen, kidney channel.

Effect：Kidney tonifying clearing liver, improving eyesight, diuresis.

Cure mainly：For soreness and weakness of waist and knees, consumptive disease hectic fever due to yin, the dizzy blurred vision of sand, raw screen film of mesh, oedema turgor.

21st, Sichuan Herba Dendrobii：

Meridian distribution of property and flavor：It is sweet, it is slightly cold.Return stomach, kidney channel.

Effect：Nourishing the stomach to improve the production of body fluid, enriching yin is except heat.

Cure mainly：For injury thirst, deficiency of food constipation, abnormal heat is not moved back, and mesh is secretly dim-sighted.

In the present invention, the pick and process of each bulk drug：

1st, Radix Angelicae Sinensis：Crude drug is taken, removes impurity, is cleaned, is run through, thinly slice, dry standby.

2nd, the root of herbaceous peony：Summer and autumn excavates, and removes soil and supporting root, removes the peel, and boiling water soaks or slightly boiled to being heated evenly, and dries.With When run through section.Raw use, stir-fry are used or wine stir-fry is standby.

3rd, rhizoma atractylodis macrocephalae：Winter excavates, and removes soil and aerial part, dries or dry.Used time macerates through water or water in which rice has been washed Section.Raw use or bran are fried, soil stir-fry is standby.

4th, Poria cocos：7~October excavates, and after banking up " sweating ", spreads out and dries in the air to dry tack free, then " sweating ", repeated multiple times, extremely Existing wrinkle, after internal moisture is largely scattered and disappeared, dries in the shade；Or fresh Poria cocos is cut into slices, dry in the shade.It is raw to use.

5th, radix bupleuri：Impurity and residual stem are removed, is cleaned, is run through, cut sheet, is dried.Raw use, or vinegar-fried use, or wine stir-fry are standby.

6th, rhizoma cyperi：Autumn excavates, and sing the hair palpus, puts and is dried after slightly boiling or steam in boiling water, or is directly dried after burning standby.

7th, root tuber of aromatic turmeric：Autumn and winter plant is excavated when withered.Win root tuber, remove fibrous root, clean soil, enter boiled in boiling water to The saturating heart, take out, dry, cut into serving pieces.

8th, Carapax Trionycis (processed)：Sandy soil are put in pot and heated, it is loose to sandy soil, it is put into net turtle shell and fries, taking-up sieve slightly yellow to epidermis Sandy soil are removed, are put into vinegar basin slightly leaching (every 100 jin with vinegar 30 jin), taking-up is dried standby.

9th, pangolin：The crust of whole is cut off after seizure, inserts in boiling water and scalded, removes scale, edulcoration dries, mothproof. It is in yellow with frying to pine bubble with sand simultaneously；Or add vinegar after frying and slightly soak, dry standby.

10th, matrimony vine：Plucked when summer, autumn fruit maturation, remove carpopodium, put after shady place dries in the air to pericarp and corrugate, then be exposed to the sun Produced to crust is stiff, pulp is soft.

11st, sealwort：Spring, the excavation of season in autumn two, remove fibrous root, clean, and put in boiling water and slightly scald or steam to the saturating heart, drying for standby.

12nd, rhizoma alismatis：Winter excavates, and cleans, low baking temperature drying, hits fibrous root and tertia, water profit section, dries.Bran is fried or salt Water, which is fried, to be used.

13rd, umbellate pore furgus：Remove silt particle after digging out, dry standby.

14th, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA：Kill removes muscles, takes its plastron, cleans and dries, and is referred to as " blood version "；Such as scalded with boiling water and after death taken The plastron gone out, it is referred to as " scalding plate ".Raw to use, sand is fried big gun and used, or sand is fried vinegar and quenched use.

15th, radix glycyrrhizae：Spring and autumn is excavated, and removes residual stem and fibrous root, or removes crust, and section is dried.It is raw with or honey process use.

16th, corn stigma：Harvested during autumn harvesting corn.Dry or be dried for standby.

17th, radish seed：Plant is tapped during summer fruit maturation, is dried, rubs seed, removes impurity, then dry standby.

18th, radix pseudostellariae：Summer major part cauline leaf is excavated when withered.Tiny fibrous root is removed, inserts slightly to scald in water and dries, or directly Connect and dry, it is raw to use.

19th, Buddhist nunnery gate of a village：It is standby for the fruit of the feverfew Buddhist nunnery gate of a village, winter harvesting.

20th, Paper mulberry Fruit：Plucked during autumn fruit maturation, clean, dry, removed the membranaceous place calyx of canescence and impurity is standby.

21st, Sichuan Herba Dendrobii：The fresh goods that harvesting is returned, can scald solarization method method by boiling water or oven drying method be processed it is standby.

The chemical composition of each bulk drug：

1st, Radix Angelicae Sinensis：Radix Angelicae Sinensis has got the chemical composition of plurality of classes, mainly there is Ligustilide class and its isomeric compound, cumarin Class, flavonoids and organic acid etc..

2nd, the root of herbaceous peony：The root of herbaceous peony is mainly containing chemical compositions such as volatile oil, single card class, triterpenes and flavonoids.

3rd, rhizoma atractylodis macrocephalae：Bighead atractylodes rhizome master contains volatile oil, and content is about 1.4%, and its main component is atractylone, atractylol etc., wherein Atractylone accounts for 32%-61%, other contents of a relatively high mainly carypohyllene, γ-elemene, cnidium monnieri -4 (14), 11- bis- The terpenoids such as alkene, gima ethylenic B.Isolated lactone constituents have atractylenolide Ⅰ, atractylenolide, white from the bighead atractylodes rhizome Art lactone III, biatractylolide, 8,9- epoxies atractylodes lactone, 4,15- epoxy hydroxyl atractylodes lactones etc..In addition, still contain polysaccharide The material such as the several amino acids such as constituents, glutamic acid and resin, bighead atractylodes rhizome triol, vitamin A.

4th, Poria cocos：Poria cocos mainly contains terpenoid, steroid compound, polysaccharide compound, protein etc..

5th, radix bupleuri：Mainly contain saikoside in radix bupleuri root, secondly containing phytosterol, adonite and a small amount of volatilization Oil, polysaccharide；Aerial part is mainly containing compositions such as flavonoids, a small amount of saponins, lignanoids, Coumarinses.

6th, rhizoma cyperi：Rhizoma cyperi mainly contains volatile oil composition, and other chemical compositions also have flavonoids, carbohydrate, triterpenes etc..

7th, root tuber of aromatic turmeric：It is containing composition, wherein volatile oil such as volatile oil, curcumin, polysaccharide, a small amount of trace elements mainly in root tuber of aromatic turmeric Root tuber of aromatic turmeric antineoplastic effective composition, curcumin are its reducing blood lipid, anti-oxidant, anti-inflammatory principle active component.

8th, Carapax Trionycis (processed)：Mainly contain the compositions such as animal glue, keratin, iodine matter, vitamin D, calcium phosphate, calcium carbonate in turtle shell, And also it is rich in 17 kinds of amino acid.

9th, pangolin：Pangolin mainly contains protein, calcium, amino acid needed by human and trace element etc..

10th, matrimony vine：The chemical composition that Chinese wolfberry fruit mainly contains includes：It is carbohydrate, amino acid, trace element, vitamin, super Superoxide dismutase, alkaloids, fat and aliphatic acid, alcohols, inorganic salts and volatile ingredient etc..

11st, sealwort：Sealwort mainly contains the compositions such as Siberian solomonseal rhizome polysaccharide, steroid saponin, lignanoids and other compositions.

12nd, rhizoma alismatis：The main chemical compositions of rhizoma alismatis are triterpene and sesquiterpenoids composition, also containing diterpene, phytosterol, are waved The chemical compositions such as hair oil, alkaloid, asparagine, steroline, aliphatic acid, protein and starch.

13rd, umbellate pore furgus：The umbellate pore furgus chemical composition reported mainly have polysaccharide, steroid, nonsteroidal (in addition to polysaccharide), Amino acids, vitamins and small-scale inorganic element etc..

14th, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA：Protein is the principle active component of tortoiseshell.

15th, radix glycyrrhizae：Radix glycyrrhizae mainly contains triterpenoid saponin, flavones ingredient, cumarin, amino acid, alkaloid and a small amount of Volatile ingredient and polysaccharide.

16th, corn stigma：The chemical composition of corn stigma is very abundant, mainly containing inorganic elements, carbohydrate, amino acid, flavonoids, A variety of chemical compositions such as volatile chemical component, organic acid, sterol, alkaloid, saponin(e.

17th, radish seed：Also radish kind, SEMEN RAPHANI are.The main fatty acids of radish seed, volatile oil.Contain first sulphur in volatile oil Alcohol, α-, β-hexenoic aldehyde and β-, γ-hexenol.Containing erucic acid, linoleic acid, leukotrienes, glycerol sinapate etc. in fat oil, go back Raphanin containing antibacterial material etc..

18th, radix pseudostellariae：Radix pseudostellariae mainly contains the compositions such as saponin(e, volatile oil, sterol, amino acid, mineral matter, starch.

19th, Buddhist nunnery gate of a village：The Buddhist nunnery gate of a village chemical composition is still not clear at present, but drug effect fancy effect is preferable.

20th, Paper mulberry Fruit：Modern pharmacological research finds that Paper mulberry Fruit contains abundant amino acid, aliphatic acid, haematochrome, biology The chemical compositions such as alkali, mineral matter, polysaccharide.

21st, Sichuan Herba Dendrobii：Composition of alkaloids is chemicals isolated from Dendrobium Sw earliest, in addition, also containing There are the compositions such as polysaccharide, luxuriant and rich with fragrance class and bibenzyl, amino acid and trace element.

Clinical observation on the therapeutic effect：

1st, case selection：

In 98 cirrhosis patients in decompensation patients, man 63, female 35,27 years old of age minimum, maximum 70 years old, its Most short 3 months of the middle course of disease, most long 3 years, all patients were typical cirrhosis patients in decompensation, and protopathy is respectively B-mode Hepatitis, hepatitis C, fatty liver, alcoholic liver.

2nd, the diagnosis basis and Standards of Chinese Medical Syndrome Differentiation of cirrhosis patients in decompensation：

According to《Clinical practice》(national higher medical education teaching material the 8th edition) diagnoses.

The diagnostic criteria of cirrhosis patients in decompensation:

First, hypofunction of liver：

1. digesting and assimilating bad, including easily suffered from diarrhoea after anorexia, nausea, apocleisis, abdominal distension, animal food.

2. it is malnutritive, including become thin, be weak, lassitude, being even unable to leave the bed.

3. jaundice, mostly parenchymal jaundice.

4. bleeding and anaemia, including nasal cavity, bleeding gums, skin and mucosa petechia, ecchymosis, hemorrhage of digestive tract.

5. endocrinopathy, including the extremely caused spider angioma of sex hormone metabolism and liver palms, hypoadrenocorticism, Thyroid hormone is abnormal.

6. irregular low-heat.

7. hypoalbuminemia.

2nd, portal hypertension：

1. ascites.

2. door-chamber Doppler flow mapping opens, including the expansion of esophagus fundus ventricularis varication, subcutaneous varicos vein of abdominal wall, haemorrhoidal vein, peritonaeum Ramus anastomoticus varicose, splenorenal shunt afterwards.

3rd, hypersplenia and splenomegaly：

According to《Chinese Internal Medicine》It is retention of dampness due to stagnation of QI that (national Higher TCM institute school programming textbook the 9th edition) is dialectical Card:

(1) primary symptom:

1. abdominal distension is not hard by it.

2. the lower turgor of the side of body or pain.

(2) secondary disease:

1. diet is reduced.

2. food after it is swollen very, obtain belch or fart slightly subtract.

3. oliguresis.

4. thin white fur of tongue is greasy.

5. veins string.

There are primary symptom 2 and secondary disease 2 to make a definite diagnosis.Symptom integral press without, it is light, in, again, primary symptom remembers 0,2,4,6 point respectively, Secondary disease remembers 0,1,2,3 respectively.

3rd, efficacy assessment standard：

Published according to China Medical Science Press in 2002《New Chinese medicine guideline of clinical investigations》In on The effect of cirrhosis patients in decompensation, standard judged：

(1) clinical cure：

1. laboratory Index for examination recovers to normal；

2. color ultrasound ascites disappears, spleen recovers to normal, and hepatic sclerosis is unchanged or even mitigates；

3. symptom integral reduces more than 80%.

(2) it is effective：

1. laboratory Index for examination is obviously improved；

2. color ultrasound ascites significantly reduces, spleen is obviously reduced, and hepatic sclerosis is substantially unchanged；

3. symptom integral reduces 60%--79%.

(3) effectively：

1. laboratory Index for examination improves；

2. color ultrasound ascites is reduced, spleen reduces, and hepatic sclerosis is without exacerbation；

3. symptom integral reduces 40%--59%；

(4) it is invalid：

1. laboratory Index for examination is without improvement or deteriorates；

2. color ultrasound ascites is without even increase is reduced, spleen is big, and hepatic sclerosis aggravates；

3. symptom integral reduces less than 39%.

4th, application method：Every time by soft capsule 5,100~150ml of warm water of the present invention, orally, 3 times a day, it is within 15 days One course for the treatment of, treat 3~6 courses for the treatment of.

5th, points for attention：

Avoid during medication and eat raw and cold, greasy, over-salty, fish raw meat and maror.Further, since conditions of patients weight and disease Journey length is different, and to drug susceptibility, there is also individual difference, most of patients can take effect in 3 courses for the treatment of, face in the 3-6 course for the treatment of Bed recovery from illness；Few patients then need the 6-8 course for the treatment of to can be only achieved clinical cure.Western medical treatment Decompensated liver cirrhosis is combined if necessary The auxiliary treating method of phase

6th, treatment results：

In 98 in cirrhosis patients in decompensation patient, the people of clinical cure 37, effective 22 people, effective 32 people, invalid 7 people, Total effective rate 92.85%.

7th, conclusion：

The present invention has an obvious therapeutic effect for cirrhosis patients in decompensation, has no toxic side effect during treatment, and medication is convenient, Total effective rate 82.65%, it is the choice drug of cirrhosis patients in decompensation patient.

8th, model case：

A, Liu, man, 65 years old, retired worker, there are more than 30 years of hepatitis B medical history, the nearly 1 month anorexia of main suit, dislike The heart, apocleisis, one's belly is tight as a drum, easily suffers from diarrhoea, becomes thin after animal food, be weak, lassitude, skin and mucosa petechia, ecchymosis, looks into liver function 9 Item shows glutamic-oxalacetic transaminease 66U/L, glutamic-pyruvic transaminase 56U/L, albumin 32.6g/L, AFP weakly positive, CDFI Show that liver volume reduces, superficial echo is coarse, splenomegaly, and ascites depth 18cm, physical examination belly has splashing sound, and skin surface is dispersed in Spider angioma, hepatitis B surface antigen and core antibody positive, antibody to hepatitis C is negative, and oliguresis, thin white fur of tongue is greasy, veins string. After oral 5 courses for the treatment of of this soft capsule, anorexia, nausea, apocleisis, one's belly is tight as a drum, easily suffers from diarrhoea, becomes thin after animal food, be weak, be spiritual The symptom such as depressed substantially mitigates, albumin 38.7g/L, and CDFI shows that liver volume is small, and superficial echo is coarse, spleen Normal in size, ascites depth 5cm, physical examination belly splashing sound disappear, and advise patient to adhere to treating, follow-up 3 years, symptom does not aggravate again.

B, Zhang, female, 38 years old, state-owned enterprise worker, hepatitis C medical history 8 years, nearly 2 weeks anorexias, one's belly is tight as a drum, become thin, Weak, lassitude, darkish complexion, look into liver function 9 and show glutamic-oxalacetic transaminease 57U/L, glutamic-pyruvic transaminase 62U/L, albumin 39.0g/L, AFP are positive, and CDFI shows that liver volume reduces, and superficial echo is coarse, splenomegaly, ascites depth 20cm, Physical examination belly has splashing sound, and hepatitis B surface antigen is negative, and antibody to hepatitis C is positive, and oliguresis, thin white fur of tongue is greasy, veins string. After 3 courses for the treatment of of this oral soft capsule, anorexia, one's belly is tight as a drum, becomes thin, be weak, lassitude, and the symptom such as darkish complexion is obvious Alleviate, albumin 42g/L, CDFI shows that liver volume is small, and superficial echo is coarse, spleen normal in size, ascites depth 8cm, physical examination belly splashing sound disappear, and advise patient to adhere to treating, follow-up 5 years, symptom does not aggravate again.

C, Lee, man, 58 years old, state-owned enterprise middle-ranking officials, fatty liver medical history 5 years, triglycerides and T-CHOL, low density lipoprotein Protein level is higher, eating greasy and surfeit flavour and drinks usually, drinks more than white wine 250ml every time.Nearly January remaining sense anorexia, One's belly is tight as a drum, weak, lassitude, sallow complexion, looks into liver function 9 displays glutamic-oxalacetic transaminease 60U/L, glutamic-pyruvic transaminase 72U/ L, albumin 35.6g/L, AFP are positive, and CDFI shows that liver volume reduces, and superficial echo is coarse, splenomegaly, and ascites is deep 13cm is spent, physical examination belly has weak splashing sound, and hepatitis B surface antigen is negative, and antibody to hepatitis C is negative, oliguresis, thin white fur of tongue It is greasy, veins string.Advise bland diet, abstinence from alcohol, after oral 3 courses for the treatment of of this soft capsule, anorexia, one's belly is tight as a drum, it is weak, spiritual not Shake, the symptom such as sallow complexion is clearly better, albumin 42g/L, CDFI shows that liver volume is small, and superficial echo is thick It is rough, spleen normal in size, ascites depth 3cm, advise patient to adhere to treating, follow-up 7 years, symptom does not aggravate again.

D, Zhang, man, 56 years old, teacher, in more than 20 years of hepatitis B medical history, does not take the medicines such as Entecavir, Aldoforwe ester Thing, often stay up late, drink once in a while, non-smoking.One's belly is tight as a drum, anorexia, weak, lassitude, complexion for main suit's sense in nearly 3 months It is dark, liver function 9 displays glutamic-oxalacetic transaminease 78U/L, glutamic-pyruvic transaminase 62U/L are looked into, albumin 33.2g/L, AFP are positive, color Color doppler ultrasound shows that liver volume reduces, and superficial echo is coarse, splenomegaly, and ascites depth 26cm, physical examination belly has splashing sound, second Liver surface antigen positive, hepatitis B core antigen is positive, and antibody to hepatitis C is negative, and oliguresis, thin white fur of tongue is greasy, veins string.Advise Take a good rest, abstinence from alcohol, after 6 courses for the treatment of of this oral soft capsule, anorexia, one's belly is tight as a drum, weak, lassitude, darkish complexion It is clearly better etc. symptom, albumin 45g/L, CDFI shows that liver volume is small, and superficial echo is coarse, and splenomegaly is small just Often, ascites depth 6cm, patient is advised to adhere to treating, follow-up 5 years, symptom does not aggravate again.

E, Zhang, man, 28 years old, health, happiness usually was drunk, and daily to drink 400-more than 500ml of white wine, main suit nearly 3 One's belly is tight as a drum, anorexia, weak, lassitude for sense in individual month, looks into liver function 9 display glutamate-oxaloacetate transaminases 79U/L, Gu Bingzhuan Ammonia enzyme 236U/L, albumin 30.1g/L, AFP are positive, and CDFI shows that liver volume reduces, and superficial echo is coarse, spleen Greatly, ascites depth 21cm, physical examination belly have splashing sound, and hepatitis B surface antigen is negative, and antibody to hepatitis C is negative, oliguresis, Thin white fur of tongue is greasy, veins string.Advise take a good rest, abstinence from alcohol, after oral 6 courses for the treatment of of this soft capsule, anorexia, one's belly is tight as a drum, it is weak, The symptoms such as lassitude disappear, albumin 45g/L, and CDFI shows that liver volume is small, and superficial echo is coarse, splenomegaly Small normal, ascites disappears, and advises patient to adhere to treating, follow-up 1 year, and CDFI shows that liver volume recovers normal, liver table Face is starlike echo, spleen normal in size, and ascites does not occur again.

F, Liu, female, 48 years old, first visit on January 5 in 2014.Hepatitis B medical history 5 years, usually short-tempered, eating is pungent It is peppery.One's belly is tight as a drum, anorexia, weak, lassitude for the nearly sense in January of main suit, looks into 9 display glutamic-oxalacetic transaminease 89U/L of liver function, Glutamic-pyruvic transaminase 36U/L, albumin 40.1g/L, AFP weakly positive, CDFI show that liver volume reduces, superficial echo Coarse, splenomegaly, ascites depth 24cm, physical examination belly has a splashing sound, and hepatitis b surface antigen positive, antibody to hepatitis C is negative, small Just it is short of, thin white fur of tongue is greasy, veins string.Regulating spirit and emotion by oneself is advised, ring is pungent, and after 4 courses for the treatment of of this oral soft capsule, anorexia, abdominal distension are such as The symptom such as bulging, weak, lassitude disappears, albumin 42g/L, and CDFI shows that liver volume is small, and superficial echo is thick Rough, spleen normal in size, ascites disappears, and advises patient to adhere to treating, follow-up 1 year, symptom is without exacerbation.

G, Mr. Wang, female, 80 years old, hepatitis B medical history 23 years, hepatic sclerosis medical history 3 years, there is abdominal distension, anorexia, weak, smart God's symptom such as depressed, sense abdominal distension aggravates within nearly 2 months, loss of appetite, nausea, weak exacerbation, is taken in then with cirrhosis patients in decompensation Institute, liver function 9 displays glutamic-oxalacetic transaminease 97U/L, glutamic-pyruvic transaminase 86U/L are looked into, albumin 32.1g/L, AFP are positive, colored Doppler ultrasound shows that liver volume is obviously reduced, and superficial echo is coarse, splenomegaly, ascites depth 33cm, and physical examination belly, which has, substantially to shake Hygrechema, hepatitis b surface antigen positive, hepatitis B core antigen is positive, and antibody to hepatitis C is negative, and oliguresis, thin white fur of tongue is greasy, Veins string.Doctor trained in Western medicine gives corresponding treatment, weak curative effect, asks the traditional Chinese medical science consultation of doctors, and orally after 1 course for the treatment of of this soft capsule, anorexia, abdominal distension are such as The symptom such as bulging, weak, lassitude slightly mitigates, and asks the doctor trained in Western medicine consultation of doctors, and using heavy dose of activating blood and removing stasis drug, conditions of patients aggravates, It is dead after 1 week.

Embodiment：

Embodiment 1：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, be made its effectively into Point bulk drug be：Radix Angelicae Sinensis l0 parts, 15 parts of the root of herbaceous peony, 15 parts of rhizoma atractylodis macrocephalae, 20 parts of Poria cocos, 6 parts of radix bupleuri, 15 parts of rhizoma cyperi, 10 parts of root tuber of aromatic turmeric, 15 parts of Carapax Trionycis (processed), 10 parts of pangolin, 15 parts of matrimony vine, 15 parts of sealwort, 20 parts of rhizoma alismatis, 15 parts of umbellate pore furgus, 15 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, 3 parts of radix glycyrrhizae, 35 parts of corn stigma, 30 parts of radish seed, 32 parts of radix pseudostellariae, 15 parts of Buddhist nunnery gate of a village, 30 parts of Paper mulberry Fruit, 15 parts of Sichuan Herba Dendrobii, each composition of the above It is processed into according to medically conventional processing method standby after soft capsule.

During use：By soft capsule 5,100~150ml of warm water of the present invention, orally, 3 times a day, 15 days are a treatment Journey, treat 3 courses for the treatment of.Avoid during medication and eat raw and cold, greasy, fish raw meat and maror, continue to stop after taking 1 month after effective With.Further, since conditions of patients weight and course of disease length are different, to drug susceptibility, there is also individual difference, most of patients It can be taken effect in 2 courses for the treatment of, clinical recovery in the 2-4 course for the treatment of；Few patients then need the 4-6 course for the treatment of to can be only achieved clinic to control More.The treatment method of western medical treatment cirrhosis patients in decompensation is combined if necessary

Embodiment 2：With embodiment 1, something in common does not repeat the application method and points for attention of the present embodiment,

Difference is：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, it, which is made, has Effect composition bulk drug be：20 parts of Radix Angelicae Sinensis, 15 parts of the root of herbaceous peony, 10 parts of rhizoma atractylodis macrocephalae, 25 parts of Poria cocos, 10 parts of radix bupleuri, 15 parts of rhizoma cyperi, root tuber of aromatic turmeric 8 parts, 20 parts of Carapax Trionycis (processed), 10 parts of pangolin, 15 parts of matrimony vine, 15 parts of sealwort, 15 parts of rhizoma alismatis, 15 parts of umbellate pore furgus, 15 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, radix glycyrrhizae 5 parts, 30 parts of corn stigma, 25 parts of radish seed, 30 parts of radix pseudostellariae, 13 parts of Buddhist nunnery gate of a village, 25 parts of Paper mulberry Fruit, 18 parts of Sichuan Herba Dendrobii, the above is each Composition is processed into standby after soft capsule according to medically conventional processing method.

Embodiment 3：With embodiment 1, something in common does not repeat the application method and points for attention of the present embodiment,

Difference is：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, it, which is made, has Effect composition bulk drug be：15 parts of Radix Angelicae Sinensis, 12 parts of the root of herbaceous peony, 13 parts of rhizoma atractylodis macrocephalae, 22 parts of Poria cocos, 8 parts of radix bupleuri, 12 parts of rhizoma cyperi, root tuber of aromatic turmeric 9 Part, 17 parts of Carapax Trionycis (processed), 9 parts of pangolin, 12 parts of matrimony vine, 13 parts of sealwort, 17 parts of rhizoma alismatis, 12 parts of umbellate pore furgus, 17 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, radix glycyrrhizae 4 Part, 33 parts of corn stigma, 28 parts of radish seed, 31 parts of radix pseudostellariae, 14 parts of Buddhist nunnery gate of a village, 27 parts of Paper mulberry Fruit, 16 parts of Sichuan Herba Dendrobii, the above respectively into Point it is processed into according to medically conventional processing method standby after soft capsule.

Embodiment 4：With embodiment 1, something in common does not repeat the application method and points for attention of the present embodiment,

Difference is：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, it, which is made, has Effect composition bulk drug be：22 parts of Radix Angelicae Sinensis, 17 parts of the root of herbaceous peony, 18 parts of rhizoma atractylodis macrocephalae, 28 parts of Poria cocos, 12 parts of radix bupleuri, 16 parts of rhizoma cyperi, root tuber of aromatic turmeric 12 parts, 22 parts of Carapax Trionycis (processed), 15 parts of pangolin, 20 parts of matrimony vine, 17 parts of sealwort, 22 parts of rhizoma alismatis, 18 parts of umbellate pore furgus, 23 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA is sweet 7 parts of grass, 39 parts of corn stigma, 35 parts of radish seed, 35 parts of radix pseudostellariae, 16 parts of Buddhist nunnery gate of a village, 33 parts of Paper mulberry Fruit, 20 parts of Sichuan Herba Dendrobii, the above Each composition is processed into standby after soft capsule according to medically conventional processing method.

Embodiment 5：With embodiment 1, something in common does not repeat the application method and points for attention of the present embodiment,

Difference is：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, it, which is made, has Effect composition bulk drug be：8 parts of Radix Angelicae Sinensis, 8 parts of the root of herbaceous peony, 8 parts of rhizoma atractylodis macrocephalae, 15 parts of Poria cocos, 5 parts of radix bupleuri, 8 parts of rhizoma cyperi, 5 parts of root tuber of aromatic turmeric, 13 parts of Carapax Trionycis (processed), 7 parts of pangolin, 10 parts of matrimony vine, 10 parts of sealwort, 15 parts of rhizoma alismatis, 10 parts of umbellate pore furgus, 16 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, 3 parts of radix glycyrrhizae, 25 parts of corn stigma, 20 parts of radish seed, 25 parts of radix pseudostellariae, 10 parts of Buddhist nunnery gate of a village, 20 parts of Paper mulberry Fruit, 10 parts of Sichuan Herba Dendrobii, each composition of the above It is processed into according to medically conventional processing method standby after soft capsule.

Embodiment 6：With embodiment 1, something in common does not repeat the application method and points for attention of the present embodiment,

Difference is：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, it, which is made, has Effect composition bulk drug be：15 parts of Radix Angelicae Sinensis, 12 parts of the root of herbaceous peony, 12 parts of rhizoma atractylodis macrocephalae, 24 parts of Poria cocos, 8 parts of radix bupleuri, 11 parts of rhizoma cyperi, root tuber of aromatic turmeric 9 Part, 18 parts of Carapax Trionycis (processed), 9 parts of pangolin, 10 parts of matrimony vine, 13 parts of sealwort, 16 parts of rhizoma alismatis, 12 parts of umbellate pore furgus, 16 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, radix glycyrrhizae 3 Part, 35 parts of corn stigma, 26 parts of radish seed, 31 parts of radix pseudostellariae, 15 parts of Buddhist nunnery gate of a village, 28 parts of Paper mulberry Fruit, 17 parts of Sichuan Herba Dendrobii, the above respectively into Point it is processed into according to medically conventional processing method standby after soft capsule.

Embodiment 7：With embodiment 1, something in common does not repeat the application method and points for attention of the present embodiment,

Difference is：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, it, which is made, has Effect composition bulk drug be：Radix Angelicae Sinensis l0 parts, 15 parts of the root of herbaceous peony, 10 parts of rhizoma atractylodis macrocephalae, 25 parts of Poria cocos, 6 parts of radix bupleuri, 15 parts of rhizoma cyperi, root tuber of aromatic turmeric 8 Part, 20 parts of Carapax Trionycis (processed), 8 parts of pangolin, 15 parts of matrimony vine, 12 parts of sealwort, 20 parts of rhizoma alismatis, 10 parts of umbellate pore furgus, 20 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, radix glycyrrhizae 3 Part, 35 parts of corn stigma, 25 parts of radish seed, 32 parts of radix pseudostellariae, 13 parts of Buddhist nunnery gate of a village, 30 parts of Paper mulberry Fruit, 15 parts of Sichuan Herba Dendrobii, the above respectively into Point it is processed into according to medically conventional processing method standby after soft capsule.

Embodiment 8；With embodiment 1, something in common does not repeat the application method and points for attention of the present embodiment,

Difference is：A kind of soft capsule for treating cirrhosis patients in decompensation, in units of parts by weight, it, which is made, has Effect composition bulk drug be：20 parts of Radix Angelicae Sinensis, 10 parts of the root of herbaceous peony, 15 parts of rhizoma atractylodis macrocephalae, 20 parts of Poria cocos, 6 parts of radix bupleuri, 15 parts of rhizoma cyperi, root tuber of aromatic turmeric 10 parts, 15 parts of Carapax Trionycis (processed), 10 parts of pangolin, 10 parts of matrimony vine, 15 parts of sealwort, 15 parts of rhizoma alismatis, 15 parts of umbellate pore furgus, 15 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA is sweet 5 parts of grass, 30 parts of corn stigma, 30 parts of radish seed, 30 parts of radix pseudostellariae, 15 parts of Buddhist nunnery gate of a village, 25 parts of Paper mulberry Fruit, 18 parts of Sichuan Herba Dendrobii, the above Each composition is processed into standby after soft capsule according to medically conventional processing method.

Claims (3)

1. A kind of 1. Chinese medicine for treating cirrhosis patients in decompensation, it is characterised in that：In units of parts by weight, its active ingredient is made Bulk drug is：Radix Angelicae Sinensis l0~20 part, 10~15 parts of the root of herbaceous peony, 10~15 parts of rhizoma atractylodis macrocephalae, 20~25 parts of Poria cocos, 6~10 parts of radix bupleuri are fragrant Attached 10~15 parts, 8~10 parts of root tuber of aromatic turmeric, 15~20 parts of Carapax Trionycis (processed), 8~10 parts of pangolin, 10~15 parts of matrimony vine, sealwort 12~15 Part, 15~20 parts of rhizoma alismatis, 10~15 parts of umbellate pore furgus, 15~20 parts of CARAPAX ET PIASTRUM TESTUDINIS PREPARATA, 3~5 parts of radix glycyrrhizae, 30~35 parts of corn stigma, radish seed 25~30 parts, 30~32 parts of radix pseudostellariae, 13~15 parts of Buddhist nunnery gate of a village, 25~30 parts of Paper mulberry Fruit, 15~18 parts of Sichuan Herba Dendrobii.
2. 2. the Chinese medicine for the treatment of cirrhosis patients in decompensation according to claim 1, it is characterised in that：In units of parts by weight, The bulk drug that its active ingredient is made is：Radix Angelicae Sinensis l0 parts, 10 parts of the root of herbaceous peony, 10 parts of rhizoma atractylodis macrocephalae, 20 parts of Poria cocos, 6 parts of radix bupleuri, rhizoma cyperi 10 Part, 10 parts of root tuber of aromatic turmeric, 15 parts of Carapax Trionycis (processed), 8 parts of pangolin, 15 parts of matrimony vine, 15 parts of sealwort, 15 parts of rhizoma alismatis, 10 parts of umbellate pore furgus, CARAPAX ET PIASTRUM TESTUDINIS PREPARATA 15 Part, 3 parts of radix glycyrrhizae, 35 parts of corn stigma, 30 parts of radish seed, 30 parts of radix pseudostellariae, 15 parts of Buddhist nunnery gate of a village, 30 parts of Paper mulberry Fruit, 15 parts of Sichuan Herba Dendrobii.
3. 3. the Chinese medicine of the treatment cirrhosis patients in decompensation according to any one of claim 1 or 2, it is characterised in that：Described Chinese medicine is soft capsule preparation.