CN104840845B - Prevent and treat Chinese medicine plastics of grice diarrhoea and preparation method thereof - Google Patents
Prevent and treat Chinese medicine plastics of grice diarrhoea and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine plastics for preventing and treating grice diarrhoea and its preparation method and application, belong to veterinary medicament field, Chinese medicine plastics of the invention is made by following steps：The bighead atractylodes rhizome, plantain seed, the banksia rose, wrinkled giant hyssop, radix glycyrrhizae, smilax, scutellaria, the Radix Astragali is taken to be condensed into liquid extract as raw material after cooking, filter, extract after being crushed, Chinese medicine plastics is made after liquid extract is uniformly mixed with film forming solution and transdermal enhancer.Product of the present invention can directly film in drug absorption effect on the navel of piglet, can be effectively improved, it is quick, grice diarrhoea cure rate is most preferably up to 90.0%, good therapeutic effect is reached, to no skin irritation, there is antibacterial, anti-inflammatory, noresidue；Preparation is simple, cost is low, is adapted to industrialized production.
Description
Technical field
The invention belongs to veterinary medicament field, and in particular to a kind of Chinese medicine plastics for preventing and treating grice diarrhoea and its preparation side
Method.
Background technology
Diarrhoea is piglet stage most commonly seen disease, and the U.S. breaks out piglet epidemic diarrhea disease since 2014, extremely
Nearly 6,000,000 of piglet is died, diarrhoea epidemic situation also occur in more ground thereafter.Recently, epidemic diarrhea loots Japanese plant again, has resulted in
Nearly 70,000 pig death.In face of the epidemic situation to have swept the globe, various countries just step up medicine of the research and development for grice diarrhoea.
Piglet epidemic diarrhea is a kind of acute infectious intestinal disease of the pig as caused by Porcine epidemic diarrhea virus, with water
Rush down, vomit and dehydration is characterized, its cause of disease belongs to the coronal viral disease category of coronaviridae.To sensitivities such as ether, chloroforms, to extraneous ring
Border and disinfectant resistance be not strong.Suckling pig, weanling pig and growing and fattening pigs the incidence of infection 100%, suckling pig is aggrieved most
Seriously, case fatality rate average 50%, often spread all over whole pig farm, and grice diarrhoea can cause under piglet survival ratio in 4~5 weeks
Drop, grow slowly, or even stagnate, huge economic loss is brought to pig industry, thus how to prevent and treat grice diarrhoea into
For a noticeable worldwide problem.
The reason for grice diarrhoea, can be divided into two kinds of pathogenicity and avirulence, and pathogenicity is mainly due to various bacteria, disease
Poison and parasite etc. cause, and avirulence stress mainly due to nutrition and feeding environment.It is thin for piglet caused by pathogenicity
Bacterium property is suffered from diarrhoea, it is necessary to which targetedly medicine is treated, i.e., the medicine need to have the direct suppression to bacterium and its toxic product
Kill and detoxication.Caused by the main reason for causing diarrhoea for avirulence is due to piglet immunological insufficiency, due to
The developing immune system imperfection of piglet, therefore when pig house has pathogen or external environment generation acute variation, piglet will
It is ill because of resistance difference, cause diarrhoea or other diseases, to be prevented for the medicine of this diarrhoea by transferring immunity of organism
Drive function and play antibacterial, bactericidal action.
At present, the Western medicine that grice diarrhoea uses Antibiotics more, still, emergence and son with antibody-resistant bacterium are prevented and treated
The resistance of pig in itself is poor, and some pig farms are bad using existing medicine control effect, and it is residual to also create livestock products medicine
Stay height, toxicity is big.
A kind of Chinese herbal medicine of effectively preventing and treating grice diarrhoea is provided in the patent application of Application No. 201310680752.2 to raise
Mixture of Chinese herbal medicines is added into feed by feed additives, the invention, but the palatability of the Chinese herbal feed additive is poor, young
Pig is very sensitive for drug smell, and the Chinese herbal medicine taste of feed addictive is excessive, and piglet can produce anorexia response, is not suitable for son
Pig is oral, and then can largely effect on drug effect.
At present on the market also without the introduction of the Chinese medicine plastics Related product for grice diarrhoea.
The content of the invention
It is bad and the problem of drug effect is bad for the oral traditional Chinese medicine palatability of existing treatment grice diarrhoea, the invention provides
A kind of Chinese medicine plastics for preventing and treating grice diarrhoea and preparation method thereof, Chinese medicine plastics can directly be applied to piglet navel position just
Absorbable drug ingedient, quick, drug residue free, cost are low.
Technical scheme is as follows：A kind of preparation method for the Chinese medicine plastics for preventing and treating grice diarrhoea, including it is as follows
Step：The bighead atractylodes rhizome, plantain seed, the banksia rose, wrinkled giant hyssop, radix glycyrrhizae, smilax, scutellaria, the Radix Astragali are taken as raw material, after being crushed through cooking,
Liquid extract is condensed into after filtering, extraction, Chinese medicine film is made after liquid extract is uniformly mixed with film forming solution and transdermal enhancer
Agent.
Further, the preparation method of the Chinese medicine plastics of described preventing and treating grice diarrhoea, comprises the following steps：
(1) 18~30 parts of the bighead atractylodes rhizome, 25~35 parts of plantain seed, 10~25 parts of the banksia rose, 8~15 parts of wrinkled giant hyssop, radix glycyrrhizae 7~15 are weighed
Part, 15~22 parts of smilax, 13~18 parts of scutellaria, 25~33 parts of the Radix Astragali, raw material are crushed to respectively 80~120 mesh, are put into each
Distinguish big fire in 15~20 times of water of material quality to cook 2~4 hours, then at 5~10 times of concentration of each material quality after cooking
To be heated to reflux extracting respectively 1~3 time in 60~80vt% ethanol, Extracting temperature is 60~65 DEG C, by each extract solution filter paper
Filtering, is configured to 1:1 each Chinese medicine liquid extract, i.e., obtain 1ml liquid extracts per 1g raw materials；
(2) each Chinese medicine liquid extract made from step (1) is mixed, received after 1500~2000r/min centrifuges 20~30min
Collect supernatant, by supernatant concentration into 2:1 mixing liquid extract, i.e., 1ml liquid extracts are obtained per 2g raw materials, it is stand-by；
(3) polyvinyl alcohol, chitosan and sodium alginate are dissolved in 2vt% aqueous acetic acid respectively, are configured to concentration
For the sodium alginate soln of 2vt% poly-vinyl alcohol solution, 5vt% chitosan solution and 2vt%, by it according to 1~3：1
~2：0.5~1 mass ratio uniformly mixes, and stirs 1 hour, obtains film forming solution；
(4) products therefrom in 10~30g steps (2) is added into every 100ml film forming solutions, stirs and dissolves, side stirring
Side adds 1~2g glycerine, stands 12~24 hours, is eventually adding 20~30g transdermal enhancers, stirs and produce Chinese medicine film
Agent；
(5) obtained finished product is sub-packed in bottle and sealed, every bottle of 10~30g.
Preferably, the raw material is 20 parts of the bighead atractylodes rhizome, 30 parts of plantain seed, 15 parts of the banksia rose, 10 parts of wrinkled giant hyssop, 10 parts of radix glycyrrhizae, native Fu
20 parts of Siberian cocklebur, 15 parts of scutellaria, 30 parts of the Radix Astragali.
Preferably, described film forming solution be concentration be 2vt% poly-vinyl alcohol solution, 5vt% chitosan solution with
And 2vt% sodium alginate soln is according to 2：1：0.5 mass ratio uniformly mixes, and stirs 1 hour and obtains.
Preferably, described transdermal enhancer is azone or propane diols.
The Chinese medicine plastics for the preventing and treating grice diarrhoea being prepared according to the method described above is also claimed in the present invention.
The bighead atractylodes rhizome (Classification system Atractylodes macrocephala) tonifying spleen, beneficial stomach, eliminating dampness, and in, it is antiabortive.Cure mainly：
Deficient QI of the spleen and stomach is controlled, do not feel like eating, the few gas of burnout, empty swollen, diarrhea, phlegm and retained fluid, oedema, jaundice, arthritis with fixed pain caused by dampness, difficult urination is dizzy, from
Sweat, nausea are uneasy.
Plantain seed (Classification system Plantago asiatica L) also known as wheel vegetable seeds, pig ear stalk, Asiatic plantain, five
More careless, field shrub, plantain seed are the mature seed of plantago plant Asiatic plantain.Cure mainly：Main difficult urination；Under stranguria with turbid discharge band；Oedema
Turgor；Summer-heat and damp rush down dysentery；Hot eyes is hidden from view；The hot cough and asthma of phlegm.
The banksia rose (Classification system Rosa cymosa Tratt)：For the dry root of the feverfew banksia rose.Acrid flavour, hardship, it is warm-natured；
Returns spleen, stomach, large intestine, three burnt, gallbladder channels；Promoting qi circulation and relieving pain, reinforcing spleen to promote digestion.
Wrinkled giant hyssop (Classification system Agastache rugosa)：Remove dampness by means of aromatics Chinese medicine, major function：Remove dampness by means of aromatics；Stop with stomach
Vomit；Driving away summer heat inducing diaphoresis.Gastral cavity abdomen ruffian Min of main damp retention in middle-jiao；Poor appetite；Vomiting；Diarrhea；The fever and chills headache of diseases caused by external factors summer-heat and damp；At the beginning of damp-warm syndrome
The heating body risen is stranded；Chest Min nausea；Nasosinusitis；Tinea of feet and hands.
Radix glycyrrhizae (Classification system Glycyrrhiza uralensis)：It is sweet, put down.The thoughts of returning home, spleen, lung, stomach.With tonifying spleen benefit
Gas, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, the effect of coordinating the drug actions of a prescription.Cure mainly：It is weakness of the spleen and the stomach, lassitude hypodynamia, palpitation,
Coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction, carbuncle sore tumefacting virus, alleviate drug toxicity, strong.
Smilax (Classification system Rhizoma Smilacis Glabrae)：It is sweet light, put down.Function：Removing toxic substances, dehumidifying, Li Guan
Section.Cure mainly：Stranguria with turbid discharge, muscles and bones contraction pain, tinea pedis, treatment furunculosis, carbuncle swells, scrofula, arthralgia and myalgia, stopping leak rush down, and control contraction ostalgia, malignant sore carbuncle
It is swollen, solution mercury powder, vermilion poison.
Radix scutellariae (Classification system Scutellaria baicalensis)：Hardship, tremble with fear.Return lung, the heart, liver, courage, large intestine channel.It is main
Control：Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis, antiabortive, hypotensive.It is yellow for damp-warm syndrome, heat temperature evil of vomitting uncomfortable in chest, damp and hot feeling of fullness, rush down dysentery
Subcutaneous ulcer, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.
The Radix Astragali (Classification system Leguminosae)：Sweet, gas tepor, gas is thin and taste is dense, and can rise to drop, the yang aspect of yang, nothing
Poison, special tonifying Qi.Starting with, lunar, foot is lunar, the warp of the few the moon of hand.With invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, the work(of expelling pus and promoting granulation
Effect.For treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, ulcer is difficult to burst, burst long not
Hold back, blood deficiency chlorosis, Heat Diabetes.
The medicinal materials such as the expensive fleece-flower root, the bark of eucommia are eliminated in the Chinese medicine material of the present invention, have selected the bighead atractylodes rhizome, Chinese herbaceous peony
Son, the banksia rose, wrinkled giant hyssop, radix glycyrrhizae, smilax, scutellaria, the Radix Astragali are combined as raw material, the taste medical instrument of the above eight have it is clearing heat and detoxicating, be good for
The effect of spleen nourishing the stomach, warm spleen cold dispelling, tonifying middle-Jiao and Qi, play primary treatment in the illnesss such as treatment diarrhoea, have concurrently disinfecting detoxifying,
The double effects of immunity are improved, synergy is produced between each herbal medicine, not only counteract the toxic side effect of constituent part, and
And the power of big tonifying spleen kidney is enhanced, the treatment of grice diarrhoea caused by pathogenicity and avirulence, short treating period, cure rate can be directed to
It is high；Film forming solution is obtained by mixing by polyvinyl alcohol and chitosan according to a certain ratio, makes Chinese medicine film-formation result good, is more easy to be applied to
On piglet skin；Transdermal enhancer is added, medicine can be made directly to be penetrated into faster by epidermis in piglet body.The present invention is to apply
The mode smeared is used as medicine, and on the one hand overcoming oral drugs needs to enter upper intestines absorbed into serum after first decomposing from liver metabolism
Liquid, then enter in piglet body each organ and then the defects of slowly effect with blood circulation, on the other hand solve in feed plus
Entering Chinese medicine additive or oral traditional Chinese medicine causes flavour of a drug big, the defects of piglet palatability difference.
Compared with prior art, the beneficial effects of the invention are as follows：(1) product of the present invention can be applied directly to the navel of piglet
On, drug absorption is fast, overcomes oral drugs palatability difference and absorbs the defects of slow；(2) Chinese medicine plastics of the invention can
Quick to effectively improve drug absorption effect, grice diarrhoea cure rate most preferably up to 90.0%, has reached good treatment effect
Fruit, to no skin irritation, there is antibacterial, anti-inflammatory, noresidue；(3) preparation is simple, cost is low, is adapted to
Industrialized production.
Embodiment
The present invention will be described in detail by the following examples, but does not limit the scope of the invention.
Embodiment 1
(1) 18 parts of the bighead atractylodes rhizome, 25 parts of plantain seed, 10 parts of the banksia rose, 8 parts of wrinkled giant hyssop, 7 parts of radix glycyrrhizae, 15 parts of smilax, scutellaria 13 are weighed
Part, 25 parts of the Radix Astragali, raw material are crushed to respectively 120 mesh, are put into big fire in 15 times of water of each material quality and are cooked 2 hours, boil
5 times of concentration after system then at each material quality is heating and refluxing extraction 3 times in 60vt% ethanol, and Extracting temperature is 60 DEG C, will
Each extract solution is filtered with filter paper, is configured to 1:1 each Chinese medicine liquid extract, i.e., obtain 1ml liquid extracts per 1g raw materials；
(2) each Chinese medicine liquid extract made from step (1) is mixed, supernatant is collected after 1800r/min centrifuges 30min,
By supernatant concentration into 2:1 mixing liquid extract, it is stand-by；
(3) by polyvinyl alcohol, chitosan and sodium alginate and it is dissolved in 2vt% aqueous acetic acid, is configured to dense respectively
Spend for the sodium alginate soln of 2vt% poly-vinyl alcohol solution, 5vt% chitosan solution and 2vt%, by it according to 3：2：
1 mass ratio uniformly mixes, and stirs 1 hour, obtains film forming solution；
(4) products therefrom in 10g steps (2) is added into every 100ml film forming solutions, stirs and dissolves, is added while stirring
Enter 2g glycerine, stand 12 hours, be eventually adding 20g azones, stir and produce Chinese medicine plastics；
(5) obtained finished product is sub-packed in bottle and sealed, every bottle of 10~30g.
Embodiment 2
(1) 20 parts of the bighead atractylodes rhizome, 30 parts of plantain seed, 15 parts of the banksia rose, 10 parts of wrinkled giant hyssop, 10 parts of radix glycyrrhizae, 20 parts of smilax, scutellaria are weighed
15 parts, 30 parts of the Radix Astragali, raw material are crushed to respectively 120 mesh, are put into big fire in 15 times of water of each material quality and are cooked 3 hours,
Concentration after cooking then at each 6 times of material quality is heating and refluxing extraction 3 times in 75vt% ethanol, and Extracting temperature is 65 DEG C, will
Each extract solution is filtered with filter paper, is configured to 1:1 each Chinese medicine liquid extract, i.e., obtain 1ml liquid extracts per 1g raw materials；
(2) each Chinese medicine liquid extract made from step (1) is mixed, supernatant is collected after 2000r/min centrifuges 20min,
By supernatant concentration into 2:1 mixing liquid extract, it is stand-by；
(3) by polyvinyl alcohol, chitosan and sodium alginate and it is dissolved in 2vt% aqueous acetic acid, is configured to dense respectively
Spend for the sodium alginate soln of 2vt% poly-vinyl alcohol solution, 5vt% chitosan solution and 2vt%, by it according to 2：1：
0.5 mass ratio uniformly mixes, and stirs 1 hour, obtains film forming solution；
(4) products therefrom in 10g steps (2) is added into every 100ml film forming solutions, stirs and dissolves, is added while stirring
Enter 2g glycerine, stand 24 hours, be eventually adding 20g propane diols, stir and produce Chinese medicine plastics；
(5) obtained finished product is sub-packed in bottle and sealed, every bottle of 10~30g.
Embodiment 3
(1) 30 parts of the bighead atractylodes rhizome, 35 parts of plantain seed, 25 parts of the banksia rose, 15 parts of wrinkled giant hyssop, 15 parts of radix glycyrrhizae, 22 parts of smilax, scutellaria are weighed
18 parts, 33 parts of the Radix Astragali, raw material are crushed to respectively 120 mesh, are put into big fire in 20 times of water of each material quality and are cooked 4 hours,
Concentration after cooking then at each 5 times of material quality is heating and refluxing extraction 3 times in 65vt% ethanol, and Extracting temperature is 63 DEG C, will
Each extract solution is filtered with filter paper, is configured to 1:1 each Chinese medicine liquid extract, i.e., obtain 1ml liquid extracts per 1g raw materials；
(2) each Chinese medicine liquid extract made from step (1) is mixed, supernatant is collected after 2000r/min centrifuges 20min,
By supernatant concentration into 2:1 mixing liquid extract, it is stand-by；
(3) by polyvinyl alcohol, chitosan and sodium alginate and it is dissolved in 2vt% aqueous acetic acid, is configured to dense respectively
Spend for the sodium alginate soln of 2vt% poly-vinyl alcohol solution, 5vt% chitosan solution and 2vt%, by it according to 1：1：
0.5 mass ratio uniformly mixes, and stirs 1 hour, obtains film forming solution；
(4) products therefrom in 30g steps (2) is added into every 100ml film forming solutions, stirs and dissolves, is added while stirring
Enter 2g glycerine, stand 24 hours, be eventually adding 30g azones, stir and produce Chinese medicine plastics；
(5) obtained finished product is sub-packed in bottle and sealed, every bottle of 10~30g.
Embodiment 4
(1) 25 parts of the bighead atractylodes rhizome, 32 parts of plantain seed, 19 parts of the banksia rose, 12 parts of wrinkled giant hyssop, 14 parts of radix glycyrrhizae, 16 parts of smilax, scutellaria are weighed
17 parts, 28 parts of the Radix Astragali, raw material are crushed to respectively 80 mesh, are put into big fire in 20 times of water of each material quality and are cooked 4 hours, boil
Concentration after system then at each 10 times of material quality is heating and refluxing extraction 2 times in 80vt% ethanol, and Extracting temperature is 64 DEG C, will be each
Extract solution is filtered with filter paper, is configured to 1:1 each Chinese medicine liquid extract, i.e., obtain 1ml liquid extracts per 1g raw materials；
(2) each Chinese medicine liquid extract made from step (1) is mixed, supernatant is collected after 1500r/min centrifuges 30min,
By supernatant concentration into 2:1 mixing liquid extract, it is stand-by；
(3) by polyvinyl alcohol, chitosan and sodium alginate and it is dissolved in 2vt% aqueous acetic acid, is configured to dense respectively
Spend for the sodium alginate soln of 2vt% poly-vinyl alcohol solution, 5vt% chitosan solution and 2vt%, by it according to 2：1：
1 mass ratio uniformly mixes, and stirs 1 hour, obtains film forming solution；
(4) products therefrom in 20g steps (2) is added into every 100ml film forming solutions, stirs and dissolves, is added while stirring
Enter 1g glycerine, stand 16 hours, be eventually adding 25g azones, stir and produce Chinese medicine plastics；
(5) obtained finished product is sub-packed in bottle and sealed, every bottle of 10~30g.
Effect experiment
Choose the age in days piglet of Dalian pig farm newborn piglet~5 and diarrhoea and the obvious piglet of clinical symptoms 300 occur,
The piglet of diarrhoea is randomly divided into five groups, one of which is blank control group, and four groups are experimental group in addition, respectively using embodiment
Chinese medicine plastics prepared by 1~4, every group of 60 piglets, observation experiment amount to 25 days.
With warm water cleaning experiment group piglet navel, rear medication is dried with dry towel, the side of the navel of each piglet to draw a circle
Formula smears the Chinese medicine plastics 30ml that in embodiment 1~4 prepared by method, three times a day, 5 days courses for the treatment of, experimental group and control
Group conventionally feeding.After daubing medicament, early daily, evening timing observation piglet excrement situation, excrement be divided into it is normal,
Dilute 5 grades of soft, sticky, water sample and bloody stool, other four kinds of grades are symptom of diarrhea in addition to the first situation, diarrhea frequency
(%)=(each group diarrhoea head number × Diarrhoea days)/(total head number × experiment number of days of each group)；Diarrhea rate (%)=each group diarrhoea head
The total head number of number/each group；Cure rate (%)=each group continues the total head number of number/each group of not suffering from diarrhoea for 2 weeks.
Impact effect of the table 1 using Chinese medicine plastics of the present invention to grice diarrhoea
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Control group | |
| Diarrhea rate | 8.33% | 5.0% | 11.7% | 11.7% | 95.0% |
| Diarrhea frequency | 1.4% | 1.1% | 1.5% | 2.1% | 91.2% |
| Death toll (head) | 1 | 0 | 2 | 2 | 48 |
| Cure rate | 88.0% | 90.0% | 86.7% | 85% | 3.3% |
| Sample size (head) | 60 | 60 | 60 | 60 | 60 |
It was found from the data in table 1, Chinese medicine plastics of the invention has obvious therapeutic effect to grice diarrhoea, wherein
The therapeutic effect of Chinese medicine plastics is best in embodiment 2, and after the Chinese medicine plastics, the diarrhea rate of piglet is reduced to 5.0%,
Diarrhea frequency also declines to a great extent to 1.1%, and cure rate is up to 90.0%, it follows that between each traditional Chinese medicine ingredients of the plastics
Unexpected synergy is played, is effectively improved grice diarrhoea symptom, and its therapeutic effect is significantly better than commercially available Chinese medicine,
Meanwhile the invention belongs to green product, in the absence of medicament residue and drug resistance equivalent risk.
The irritation test of the Chinese medicine plastics of the embodiment of the present invention 1~4
(1) experimental animal is handled：
Take in mouse 16, male and female half and half similar in the laboratory rearing cleaning grade body weight of 5 days, be randomly divided into 8 groups, in fact
Test first 24 hours, give mouse web portion shaving.After the sterilization of the mouse skin of experimental group 1~4, drawn with No. 6 syringe needles of sterilizing into " well " font
Broken both sides skin, skin is set oozing of blood occur for degree, damage zone area 3cm × 3cm, as damaged skin experimental group, experimental group 5~
8 mouse skin intact unbrokens.
(2) it is administered：
Experimental group 1~4 is damaged skin experimental group, and experimental group 5~8 is intact skin group, is to smear 1 time daily, even
It is continuous to smear 7 days.Every group of left side daubing medicament, right side is blank control, and it is 1g/kg that capacity is administered every time, smears embodiment 1 respectively
Chinese medicine plastics prepared by~4 method, each group remove tested material after last time is smeared 24 hours, with warm water cleaning,
Remove tested material and smear area skin whether there is the change such as erythema and oedema after observation in 24 hours, 48 hours and 72 hours.
(3) experimental result：
The mouse skin of experimental group 1~4 did not occurred erythema and redness, and the mouse of experimental group 5~8 does not occur redness, filled
Blood phenomenon disappeared in 24 hours.
From above experimental result, local 1 time or repeatedly after medication of Chinese medicine plastics of the invention, to normal and damaged
Skin it is nonirritant, therefore the present invention can be applied directly on the navel of piglet, drug absorption is fast, overcomes oral drugs
The defects of palatability difference and slow absorption.Product of the present invention have can effectively improve drug absorption effect, quick, grice diarrhoea
Cure rate has reached good therapeutic effect, has had the advantages that antibacterial, anti-inflammatory, noresidue up to 90.0%.The preparation technology of product
It is simple and easy, cost is low, be adapted to industrialized production.
Claims (5)
1. a kind of preparation method for the Chinese medicine plastics for preventing and treating grice diarrhoea, it is characterised in that comprise the following steps：
(1) weigh 18~30 parts of the bighead atractylodes rhizome, 25~35 parts of plantain seed, 10~25 parts of the banksia rose, 8~15 parts of wrinkled giant hyssop, 7~15 parts of radix glycyrrhizae,
15~22 parts of smilax, 13~18 parts of radix scutellariae, 25~33 parts of the Radix Astragali, raw material are crushed to respectively 80~120 mesh, are put into each raw material
In 15~20 times of water of quality distinguish big fire cook 2~4 hours, after cooking then at each material quality 5~10 times of concentration 60~
In being heated to reflux extracting respectively 1~3 time in 80vt% ethanol, Extracting temperature is 60~65 DEG C, and each extract solution is filtered with filter paper,
It is configured to 1:1 each Chinese medicine liquid extract, i.e., obtain 1ml liquid extracts per 1g raw materials；
(2) each Chinese medicine liquid extract made from step (1) is mixed, collected after 1500~2000r/min centrifuges 20~30min
Clear liquid, by supernatant concentration into 2:1 mixing liquid extract, i.e., 1ml liquid extracts are obtained per 2g raw materials, it is stand-by；
(3) polyvinyl alcohol, chitosan and sodium alginate are dissolved in 2vt% aqueous acetic acid respectively, are configured to concentration difference
For 2vt% poly-vinyl alcohol solutions, 5vt% chitosan solutions and 2vt% sodium alginate solns, by it according to 1~3：1~2：
0.5~1 mass ratio uniformly mixes, and stirs 1 hour, obtains film forming solution；
(4) products therefrom in 10~30g steps (2) is added into every 100ml film forming solutions, stirs and dissolves, is added while stirring
Enter 1~2g glycerine, stand 12~24 hours, be eventually adding 20~30g transdermal enhancers, stir and produce Chinese medicine plastics；
(5) obtained finished product is sub-packed in bottle and sealed.
2. the preparation method of the Chinese medicine plastics of preventing and treating grice diarrhoea according to claim 1, it is characterised in that the original
Expect for 20 parts of the bighead atractylodes rhizome, 30 parts of plantain seed, 15 parts of the banksia rose, 10 parts of wrinkled giant hyssop, 10 parts of radix glycyrrhizae, 20 parts of smilax, 15 parts of radix scutellariae, the Radix Astragali 30
Part.
3. the preparation method of the Chinese medicine plastics of preventing and treating grice diarrhoea according to claim 1, it is characterised in that described
Film forming solution is poly-vinyl alcohol solution, 5vt% chitosan solution and the 2vt% sodium alginate soln that concentration is 2vt%
According to 2：1：0.5 mass ratio uniformly mixes, and stirs 1 hour and obtains.
4. the preparation method of the Chinese medicine plastics of preventing and treating grice diarrhoea according to claim 1, it is characterised in that described
Transdermal enhancer be azone or propane diols.
A kind of 5. Chinese medicine plastics for the preventing and treating grice diarrhoea being prepared according to claim 1 methods described.
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| CN201510320737.6A CN104840845B (en) | 2015-06-11 | 2015-06-11 | Prevent and treat Chinese medicine plastics of grice diarrhoea and preparation method thereof |
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| CN104840845A CN104840845A (en) | 2015-08-19 |
| CN104840845B true CN104840845B (en) | 2017-12-29 |
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| 仔猪腹泻的原因及防治措施;刘利华;《现代农业科技》;20091231(第21期);第283-284页 * |
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