CN104840772A - External patch for relieving leg systremma and preparation method - Google Patents
External patch for relieving leg systremma and preparation method Download PDFInfo
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Abstract
The invention discloses an external patch for relieving leg systremma. The external patch is prepared by the following raw materials in parts by mass: 7 to 12 parts of psoralea corylifolia, 8 to 16 parts of notopterygium root, 9 to 15 parts of honey-fried licorice root, 4 to 9 parts of twotooth achyranthes root, 6 to 9 parts of Indian epimeredi herb, 8 to 12 parts of stem of noble dendrobium, 9 to 15 parts of pawpaw, 10 to 15 parts of cassia twig, 10 to 15 parts of white peony root, 8 to 12 parts of sea-ear shell, 10 to 20 parts of root of kudzu vine, 4 to 9 parts of gastrodia elata, and 5 to 10 parts of chastetree fruit. The external patch has the beneficial effects that by using multiple traditional Chinese medicines, the compounding is reasonable, the effect of treating the leg systremma is better, the effect of treating both symptoms and root causes is realized, the effect is quick, the toxic and side effect is avoided, and the easiness in reoccurrence after curing is avoided; the obtaining of medicine sources is easy, the cost of medicines is low, and the burden of a patient is reduced.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of external plaster application agent and the preparation method of alleviating shank sural spasm.
Background technology
Sural spasm, i.e. " Leg Cramps ".Be modal one in cramp, be characterized in the tatanic cramp that gastrocnemius breaks out, hold up, bitterly as reversed, lasting tens of second was to several minutes or more for a long time, its pain is difficult to describe.Although knot only continue a few minutes, after outbreak, sense of discomfort or the tenderness of muscle can continue several hours.Clinically, common is that old people's shank gastrocnemius knots, and when often betiding nighttime sleep, continuous outbreak can affect sleep, reduces quality of life.People generally believe, Leg Cramps all causes due to calcium deficiency in body, is in fact far from being literally true.Investigation finds, has considerable old people after calcium supplementary treatment, knots and still has outbreak.
Cause the most commonly encountered diseases of Leg Cramps because being calcium deficiency.Secondly, also have certain situation to belong to Secondary cases cramp in the leg, such as multiple myonosus, peripheral neurophaty, uremia, diabetes, thyroid disease etc., can cause cramp in the leg.In addition, take some drugs, as hormones, the morphine of pain relieving, the cimetidine for the treatment of gastropathy, the diuretic etc. of blood pressure lowering, also has the side effect causing cramp in the leg.Some old people's lower extremities, make narrowed blood vessels, blood supply insufficiency, circulation not smooth, cause the metabolite of leg not taken away by blood in time.These metabolic product accumulation, in leg muscle, when reaching finite concentration, stimulated muscle will shrink, cramp in the leg occur.The traditional Chinese medical science claims Leg Cramps to be " contraction emergency case ", think that liver governing tendons, all limbs muscle arteries and veins contractures all blame in liver.Because of deficiency of liver-blood, caused by blood failing to nourish tendons.
The Chinese invention patent document of application publication number CN 104274603 A (application number 201410479538.5) discloses a kind of Chinese medicine being used for the treatment of Leg Cramps, is made up of the medicine of following weight: 30 grams, Radix Rehmanniae Preparata, Fructus Corni 12 grams, Radix Angelicae Sinensis 24 grams, the Radix Paeoniae Alba 30 grams, Fructus Lycii 15 grams, Fructus Chaenomelis 12 grams, Radix Glycyrrhizae Preparata 10 grams, Radix Achyranthis Bidentatae 12 grams, Herba Lycopodii 15 grams, Herba Leonuri 15 grams, Pericarpium Citri Reticulatae 9 grams, Caulis Spatholobi 15 grams.The Chinese invention patent document of application publication number CN 104491250 A (application number 201410850196.3) discloses a kind of medicine and preparation method for the treatment of Leg Cramps, is made up of the component of following parts by weight: Radix Glycyrrhizae, Rhizoma Homalomenae, Ramulus Cinnamomi, Herba Epimedii, Rhizoma Curculiginis, Rhizoma Drynariae, Radix Platycodonis, Caulis Spatholobi, Caulis Piperis Kadsurae, Radix Achyranthis Bidentatae, Radix Dipsaci, the Cortex Eucommiae, Cortex Acanthopancis, Herba Lycopodii, parasitism, Herba speranskiae tuberculatae, Radix Saposhnikoviae, Eupolyphaga Seu Steleophaga, Herba Menthae, Radix Rhodiolae, Radix Ginseng, Radix Cynanchi Paniculati, Spina Gleditsiae, Pheretima, each 1 part of Pericarpium Zanthoxyli, Fructus Gleditsia 5 parts.The Chinese invention patent document of application publication number CN 104415205 A (application number 201310379912.X) discloses one and treats cramp in the leg prescription at night, be made up of the component of following parts by weight: Radix Bupleuri 6 grams, Radix Codonopsis 24 grams, 45 grams, Radix Rehmanniae Preparata, Rhizomadioscoreae 24 grams, Fructus Lycii 18 grams, Radix Puerariae 18 grams, Cortex Moutan 9 grams, Radix Paeoniae Rubra 24 grams, Radix Glycyrrhizae Preparata 6 grams.
At present for the control of knotting, be all emphasize diet, warming, exercise prophylactic treatment, for the people with easy cramp body constitution mostly, cannot be regulated by the warming exercise of diet, need chemoprophylaxis, the medicine of prophylactic treatment cramp is less clinically at present, and treatment window is also narrower.
Summary of the invention
The object of this invention is to provide that a kind of therapeutic domain is wide, short treating period, the evident in efficacy and external plaster application agent of alleviation shank sural spasm without side reaction.
Technical scheme of the present invention is:
Alleviate the external plaster application agent of shank sural spasm, be prepared from by following raw material, be mass parts: Fructus Psoraleae 7-12; Rhizoma Et Radix Notopterygii 8-16; Radix Glycyrrhizae Preparata 9-15; Radix Achyranthis Bidentatae 4-9; Fail clothing 6-9; Herba Dendrobii 8-12; Fructus Chaenomelis 9-15; Ramulus Cinnamomi 10-15; Radix Paeoniae Alba 10-15; Concha Haliotidis 8-12; Radix Puerariae 10-20; Rhizoma Gastrodiae 4-9; Fructus Viticis 5-10.
In preferred scheme, Fructus Psoraleae 8-11; Rhizoma Et Radix Notopterygii 10-14; Radix Glycyrrhizae Preparata 11-13; Radix Achyranthis Bidentatae 5-8; Fail clothing 7-8; Herba Dendrobii 9-11; Fructus Chaenomelis 11-13; Ramulus Cinnamomi 11-14; Radix Paeoniae Alba 11-14; Concha Haliotidis 9-11; Radix Puerariae 13-17; Rhizoma Gastrodiae 5-8; Fructus Viticis 6-9.
Be more preferably, Fructus Psoraleae 9.5; Rhizoma Et Radix Notopterygii 12; Radix Glycyrrhizae Preparata 12; Radix Achyranthis Bidentatae 6.5; To fail clothing 7.5; Herba Dendrobii 10; Fructus Chaenomelis 12; Ramulus Cinnamomi 12.5; The Radix Paeoniae Alba 12.5; Concha Haliotidis 10; Radix Puerariae 15; Rhizoma Gastrodiae 6.5; Fructus Viticis 7.5.
Alleviate the preparation method of the external plaster application agent of shank sural spasm, step is as follows:
(1) Concha Haliotidis is cleaned, and puts and smokeless stove fire is calcined to crisp, put and dry in the air, smash to pieces, for subsequent use; Fructus Psoraleae soaks under being placed in saline room temperature 10-20 hour (soaking 13-17 hour under preferred room temperature), takes out, is placed in Chinese medicine pan, add the Oleum Brassicae campestris that mass fraction is 11%, slow fire heats, and fries and heaves to micro-, during savory effusion, taking-up cools, smash to pieces grind for subsequent use;
(2) Ramulus Cinnamomi is cleaned, be placed in clear water and run through, shave; Get the refined honey (preferably getting the refined honey of 0.18 times of Ramulus Cinnamomi amount) of 0.15-0.20 times of Ramulus Cinnamomi amount, after thin up, drench in Ramulus Cinnamomi sheet, moistening, then be placed in frying pan, slow fire heats, and fries to strong yellow, and tack-free is degree, taking-up cools, and is ground into fine powder, for subsequent use; Radix Glycyrrhizae Preparata is ground into fine powder, for subsequent use;
(3) Fructus Chaenomelis and Fructus Viticis are placed in thermostatic drying chamber, first in 72-80 DEG C of dry 14-20 minute (being preferable over 74-78 DEG C of dry 16-18 minute), then adjust the temperature to 45-55 DEG C of dry 50-70 minute (preferably adjusting the temperature to 48-52 DEG C of dry 55-65 minute), take out, be placed in Chinese medicine grinder and be ground into fine powder, the raw material medicated powder after processing with step (1) and step (2) mixes, and sieves, obtain mixed powder, for subsequent use;
(4) Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, the Radix Paeoniae Alba, Radix Puerariae and Rhizoma Gastrodiae are together placed in Chinese medicinal pot, add pure water to soak, after medical material fully expands, big fire heated and boiled 6-10 minute (preferred big fire heated and boiled 8 minutes), turn little fire and decoct 36-58 minute, filter, medicinal residues add clear water and did not have powder 3-4cm, and moderate heat heating decocts 12-34 minute, filter, twice filter decocting liquid merges, and is again filtered by gained decocting liquid through three layers of cotton cloth, reduces the impurity in filtrate as far as possible;
(5) be the thick paste of 1.15-1.20 by step (4) gained filtrate reduced in volume to a 70 DEG C relative density, step (3) gained mixed powder is added in above-mentioned thick paste, camphorate simultaneously, Borneolum Syntheticum and azone, blender rapid stirring is even, metering (preferably according to the metering that the 18g/ pastes) uniform application pasted according to 15-20g/, on kraft paper, to obtain final product.
The preparation method of the external plaster application agent of above-mentioned alleviation shank sural spasm, preferred scheme is, the middle 90-150 mesh sieve excessively of step (3) (preferred 110-130 mesh sieve excessively, mistake 120 mesh sieve be more preferably).
The preparation method of the external plaster application agent of above-mentioned alleviation shank sural spasm, preferred scheme is, the pure water (preferably adding the pure water of 8-10 times of material quantity, the pure water adding 9 times of material quantities be more preferably) of 6-12 times of material quantity is added in step (4).
The preparation method of the external plaster application agent of above-mentioned alleviation shank sural spasm, preferred scheme is, the time of soaking in step (4) is 1.6-3.4 hour (the preferred time of soaking is 2.0-3.0 hour, and the time of the immersion be more preferably is 2.5 hours).
The preparation method of the external plaster application agent of above-mentioned alleviation shank sural spasm, preferred scheme is, the medium and small fire of step (4) decocts 44-50 minute (preferred little fire decocts 47 minutes).
The preparation method of the external plaster application agent of above-mentioned alleviation shank sural spasm, preferred scheme is, in step (4), moderate heat heating decocts 18-28 minute (preferred moderate heat heating decoction 23 minutes).
The preparation method of the external plaster application agent of above-mentioned alleviation shank sural spasm, preferred scheme is, the mass ratio of step (5) Raw medicine and Camphora, Borneolum Syntheticum and azone is 6: 1.7: 1.5: 1.3.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Fructus Psoraleae: base is former: be the fruit of legumes psoraleae.Chemical analysis: fruit is containing volatile oil about 20%, organic acid, a kind of methyl glucoside, alkali soluble resins, fixedness terpenoid oil, Saponin.Seed containing Coumarins psoralen and isopsorapen altogether about 1.1%, flavonoid bavachin, bavachinin, isobavachin and chalcone Bavachalcone, corylifolinin, monoterpene amphyl Bakuchiol; Still containing volatile oil, resin, fatty oil.Spend fatty oil, volatile oil, sterol, alkaloid etc.This plant is also containing Raffinose.Nature and flavor: pungent, temperature.Gui Jing: enter kidney channel.Function cures mainly: reinforcing the kidney and supporting YANG.Control cold diarrhea of suffering from a deficiency of the kidney, the enuresis, spermatorrhea, frequent micturition, sexual impotence, chills and pain of the waist and kness, deficiency and coldness is breathed heavily and is coughed.External curing vitiligo.
Rhizoma Et Radix Notopterygii: base is former: this product is dry rhizome and the root of samphire Rhizoma Et Radix Notopterygii or Radix et Rhizoma Notopterygii.Chemical analysis: Radix et Rhizoma Notopterygii is containing volatilization wet goods.Nature and flavor: pungent, bitter, temperature.Gui Jing: return bladder, kidney channel.Effect: cold expelling, dispels the wind, dehumidifying, pain relieving.Cure mainly: for anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Radix Glycyrrhizae: base is former: this product is the dry root and rhizome of glycyrrhizic legume, Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L..Nature and flavor: sweet are flat.Gui Jing: GUIXIN.Lung, spleen, stomach warp.Effect: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly: for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of institute's abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.The concocting method of Radix Glycyrrhizae Preparata: Radix Glycyrrhizae tabellae is added cooked Mel and a little boiled water, slightly vexed after mixing thoroughly, put in pot fry to buff and tack-free time, take out dry in the air cool (every 100 jin with cooked Mel 25-30 jin).
Radix Achyranthis Bidentatae: base is former: this product is the dry root of amaranthaceous plant Radix Achyranthis Bidentatae.Nature and flavor: bitter, sour are flat.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.Chemical analysis: root containing Saponin, and contains ecdysterone and inokosterone.
To fail clothing: base is former: medical material Ji Yuan: be the herb of the wide Radix Saposhnikoviae of labiate.Chemical analysis: 1. herb is containing volatile oil and alkaloid.Leaf is containing Herba Epimeredis Indicae dilactone again.Aerial parts is containing Herba Epimeredis Indicae dilactone.Aerial parts containing Herba Epimeredis Indicae glycoside, apigenin-7-O-beta-D-(2 "; 6 " the p-coumaric acyl of-bis--O-)-glycoside, apigenin-7-O-beta-D-(4 "; 6 " the p-coumaric acyl of-bis--O-) glycoside, 5-hydroxyl-6,7,3 ', 4-tetramethoxy flavones, 5,4 '-dihydroxy-6,7,3 '-trimethoxy flavone and apigenin.Root is containing lignocerane, tetracosanol, β-Amyrin, freidelin, betulic acid, and diterpene compound Herba Epimeredis Indicae lactone, anisomelic acid and chromocor compound Herba Epimeredis Indicae element.Nature and flavor: acrid in the mouth; Bitter; Property is put down.Function cures mainly: wind-damp dispelling; Disappear sore.Main cold, fever; Rheumatic arthralgia; Strengthening bone and muscle; The people that suffers from a deficiency of the kidney gets its infusing drugs in wine drink.
Herba Dendrobii: base is former: be the stem of orchid Dendrobium nobile or its multiple congener.Chemical analysis: Dendrobium nobile contains dendrobine, dendramine, Herba Dendrobii time alkali, dendroxine, dendrine, 6-hydroxydendroxine, still mucous matter, starch.Dendrobium moniliformeSweet is containing dendrobine, dendramine and N-methyl dendrobine (quaternary ammonium salt).Sieve river Herba Dendrobii is containing shihunine.Nature and flavor: sweet light micro-salty, cold.Gui Jing: enter stomach, lung, kidney channel.Function cures mainly: promote the production of body fluid stomach reinforcing, clearing away heat and nourishing YIN.Control consumption of body fluid caused by febrile disease, xerostomia excessive thirst, after being ill deficiency-heat, it is dark that the moon hinders order.
Fructus Chaenomelis: base is former: be the fruit of rosaceous plant chaenomeles lagenaria.Chemical analysis: containing malic acid, tartaric acid, citric acid, Saponin and flavonoid, fresh fruit contains hydrocyanic acid containing catalase seed.Nature and flavor: acid, temperature.Gui Jing: enter liver, spleen channel.Function cures mainly: suppressing the hyperactive liver and easing the stomach, and dry relaxing muscles and tendons.Control convulsion of vomiting and diarrhoea, arthralgia chiefly caused by damp pathogen, beriberi, edema, dysentery.
Ramulus Cinnamomi: base is former: this product is the dry twig of canella Cortex Cinnamomi.Nature and flavor: acrid, sweet, warm.Gui Jing: GUIXIN, lung, urinary bladder channel.Effect: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Cure mainly: for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.Pharmacological action: 1, antibacterial action, 2, antivirus action, 3, diuresis.
The Radix Paeoniae Alba: base is former: this product is the dry root of ranunculaceae plant Radix Paeoniae.Chemical analysis: root contains paeoniflorin, paeonol, paeoniflorin, benzoic acid about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes.Nature and flavor: bitter, sour, are slightly cold.Gui Jing: return liver, spleen channel.Effect: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Cure mainly: dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Concha Haliotidis: base is former: this product is the shell of Bao Ke animal Haliotis diversicolor, haliotis discus hannai Ino, sheep Bao, haliotis ruber, Er Bao or white Bao.Nature and flavor: salty, cold.Gui Jing: return Liver Channel.Effect: suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving.Cure mainly: dizzy for having a headache, cataract, blurring of vision, optic atrohic blindness nyctalopia.
Radix Puerariae: base is former: this product is the dry root of legume pueraria lobata.Character: this product is rectangle sheet or the blockage of rip cutting.Crust light brown, has vertical wrinkle, coarse.Tangent plane yellow-white, texture is not obvious.Matter is tough, and fibroid is strong.Nature and flavor: sweet, pungent, cool.Gui Jing: return spleen, stomach warp.Effect: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.Cure mainly: for fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Rhizoma Gastrodiae: base is former: be the tuber of sky section Gastrodia plant Rhizoma Gastrodiae.Composition: Rhizoma Gastrodiae is containing phenols: namely Gastrodine claims gastrodine, gastrodioside, 4-ethoxymethyl phenol, hydroxy benzaldehyde, 3,4-4-dihydroxy benzaldehyde; Aromatic compound: 4-acrinyl methyl ether etc.The property of medicine: sweet, pungent, flat.Return Liver Channel.Function cures mainly: relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, tic contracture, tetanus, dizzy, headache, hemiplegia, limb fiber crops, rheumatic arthralgia.
Fructus Viticis: base is former: this product is the dry mature fruit of Verbenaceae Vitex rotundifolia or wild pepper.Character: this product is spherical in shape, diameter 4-6mm.Surface grey black or pitchy, by canescence Refined Mercurous chloride shape fine hair, have longitudinal shallow ridges 4, top nick, base portion has canescence Constellation calyx and short carpopodium.Nature and flavor: pungent, bitter, are slightly cold.Gui Jing: return bladder, liver, stomach warp.Effect: dispelling wind and heat pathogens, the clear sharp head.Cure mainly: for anemopyretic cold headache, gingivitis, the many tear of conjunctival congestion, poor vision, has a dizzy spell.
External plaster application agent scientific formula provided by the invention, preparation method is simple, and products obtained therefrom is easy to use, be easy to carry.In addition, excellent results of the present invention also shows:
1, the present invention adopts kinds of traditional Chinese medicines to prepare, and rationally, treatment Leg Cramps curative effect is good, treating both the principal and secondary aspects of a disease, instant effect, have no side effect in collocation, does not recur after recovery from illness;
2, the present invention has suppressing the hyperactive liver pain relieving, endogenous wind stopping relieving convulsion, and effect of promoting the flow of QI-blood by warming the meridian fundamentally can be eliminated focus, reach strengthening the body resistance, the object of thoroughly curing;
3, medicine source of the present invention is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 alleviates the external plaster application agent of shank sural spasm, is prepared from by following raw material, is mass parts (45g/ part): Fructus Psoraleae 7 parts; Rhizoma Et Radix Notopterygii 8 parts; Radix Glycyrrhizae Preparata 9 parts; Radix Achyranthis Bidentatae 4 parts; To fail 6 parts, clothing; Herba Dendrobii 8 parts; Fructus Chaenomelis 9 parts; Ramulus Cinnamomi 10 parts; The Radix Paeoniae Alba 10 parts; Concha Haliotidis 8 parts; Radix Puerariae 10 parts; 4 parts, Rhizoma Gastrodiae; Fructus Viticis 5 parts.
The preparation method alleviating the external plaster application agent of shank sural spasm is:
(1) Concha Haliotidis is cleaned, and puts and smokeless stove fire is calcined to crisp, put and dry in the air, smash to pieces, for subsequent use; Fructus Psoraleae is placed under saline room temperature and soaks 10 hours, and take out, be placed in Chinese medicine pan, add the Oleum Brassicae campestris that mass fraction is 11%, slow fire heats, and fry and heaves to micro-, during savory effusion, taking-up cools, and it is for subsequent use to smash grinding to pieces;
(2) Ramulus Cinnamomi is cleaned, be placed in clear water and run through, shave; Get the refined honey of 0.15 times of Ramulus Cinnamomi amount, after thin up, drench in Ramulus Cinnamomi sheet, moistening, is then placed in frying pan, and slow fire heats, and fries to strong yellow, and tack-free is degree, and taking-up cools, and is ground into fine powder, for subsequent use; Radix Glycyrrhizae Preparata is ground into fine powder, for subsequent use;
(3) Fructus Chaenomelis and Fructus Viticis are placed in thermostatic drying chamber, first in 72 DEG C of dryings 14 minutes, then 45 DEG C of dryings 50 minutes are adjusted the temperature to, take out, be placed in Chinese medicine grinder and be ground into fine powder, the raw material medicated powder after processing with step (1) and step (2) mixes, and crosses 90 mesh sieves, obtain mixed powder, for subsequent use;
(4) Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, the Radix Paeoniae Alba, Radix Puerariae and Rhizoma Gastrodiae are together placed in Chinese medicinal pot, the pure water adding 6 times of material quantities soaks 1.6 hours, after medical material fully expands, and big fire heated and boiled 6 minutes, turn little fire to decoct 36 minutes, filter, medicinal residues add clear water and did not have powder 3-4cm, moderate heat heating decoction 12 minutes, filter, twice filter decocting liquid merges, and is again filtered by gained decocting liquid through three layers of cotton cloth, reduces the impurity in filtrate as far as possible;
(5) be the thick paste of 1.15-1.20 by step (4) gained filtrate reduced in volume to a 70 DEG C relative density, step (3) gained mixed powder is added in above-mentioned thick paste, camphorate simultaneously, Borneolum Syntheticum and azone (mass ratio of crude drug and Camphora, Borneolum Syntheticum and azone is 6: 1.7: 1.5: 1.3), blender rapid stirring is even, the metering uniform application pasted according to 15g/, on kraft paper, to obtain final product.
The using method of gained external plaster application agent of the present invention is: cleaned up in affected part, get this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.
Embodiment 2 alleviates the external plaster application agent of shank sural spasm, is prepared from by following raw material, is mass parts (25g/ part): Fructus Psoraleae 12 parts; Rhizoma Et Radix Notopterygii 16 parts; Radix Glycyrrhizae Preparata 15 parts; Radix Achyranthis Bidentatae 9 parts; To fail 9 parts, clothing; Herba Dendrobii 12 parts; Fructus Chaenomelis 15 parts; Ramulus Cinnamomi 15 parts; The Radix Paeoniae Alba 15 parts; Concha Haliotidis 12 parts; Radix Puerariae 20 parts; 9 parts, Rhizoma Gastrodiae; Fructus Viticis 10 parts.
The preparation method alleviating the external plaster application agent of shank sural spasm is:
(1) Concha Haliotidis is cleaned, and puts and smokeless stove fire is calcined to crisp, put and dry in the air, smash to pieces, for subsequent use; Fructus Psoraleae is placed under saline room temperature and soaks 20 hours, and take out, be placed in Chinese medicine pan, add the Oleum Brassicae campestris that mass fraction is 11%, slow fire heats, and fry and heaves to micro-, during savory effusion, taking-up cools, and it is for subsequent use to smash grinding to pieces;
(2) Ramulus Cinnamomi is cleaned, be placed in clear water and run through, shave; Get the refined honey of 0.20 times of Ramulus Cinnamomi amount, after thin up, drench in Ramulus Cinnamomi sheet, moistening, is then placed in frying pan, and slow fire heats, and fries to strong yellow, and tack-free is degree, and taking-up cools, and is ground into fine powder, for subsequent use; Radix Glycyrrhizae Preparata is ground into fine powder, for subsequent use;
(3) Fructus Chaenomelis and Fructus Viticis are placed in thermostatic drying chamber, first in 80 DEG C of dryings 20 minutes, then 55 DEG C of dryings 70 minutes are adjusted the temperature to, take out, be placed in Chinese medicine grinder and be ground into fine powder, the raw material medicated powder after processing with step (1) and step (2) mixes, and crosses 150 mesh sieves, obtain mixed powder, for subsequent use;
(4) Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, the Radix Paeoniae Alba, Radix Puerariae and Rhizoma Gastrodiae are together placed in Chinese medicinal pot, the pure water adding 12 times of material quantities soaks 3.4 hours, after medical material fully expands, and big fire heated and boiled 10 minutes, turn little fire to decoct 58 minutes, filter, medicinal residues add clear water and did not have powder 3-4cm, moderate heat heating decoction 34 minutes, filter, twice filter decocting liquid merges, and is again filtered by gained decocting liquid through three layers of cotton cloth, reduces the impurity in filtrate as far as possible;
(5) be the thick paste of 1.15-1.20 by step (4) gained filtrate reduced in volume to a 70 DEG C relative density, step (3) gained mixed powder is added in above-mentioned thick paste, camphorate simultaneously, Borneolum Syntheticum and azone (mass ratio of crude drug and Camphora, Borneolum Syntheticum and azone is 6: 1.7: 1.5: 1.3), blender rapid stirring is even, the metering uniform application pasted according to 20g/, on kraft paper, to obtain final product.
The using method of gained external plaster application agent of the present invention is: cleaned up in affected part, get this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.
Model case: old XX, man, 41 years old, patient's readme: left leg is often had a cramp, mostly in outbreak at night, during outbreak, calf has gathered a bag, and lower limb can not stretch, in local hospital inspection, think that calcium deficiency causes, Mr. Chen takes calcium tablet three months, and Leg Cramps symptom does not have and alleviates, depressed, uncomfortable.Introduced through friend afterwards, and came here on October 19th, 2013 and check treatment.Check: patient's left leg gastrocnemius muscle is stiff, that touches feels cold, and Ipsilateral thumb also takes out contraction to the sufficient heart, hurt like hell, and stringy and thready pulse is straight, the few tongue of deep red tongue.Tcm diagnosis is because of deficiency of liver-blood, blood failing to nourish tendons, the shank sural spasm caused by muscle thready pulse is anxious.
Use the present embodiment gained to alleviate the external plaster application agent of shank sural spasm, using method: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.After using two courses for the treatment of, patient's conscious left leg skin is warm, and Leg Cramps number of times greatly reduces, take out through time pain alleviate; Continue two courses for the treatment of of use, patient's left leg cramp symptom is eliminated substantially, and Ipsilateral thumb spasm disappears completely, suggestion patient continues to take two courses for the treatment of and is consolidated, and drug withdrawal was paid a return visit after three months, and patient's left leg sural spasm is eliminated completely, patient activity is normal, without any side reaction.
Embodiment 3 alleviates the external plaster application agent of shank sural spasm, is prepared from by following raw material, is mass parts (40g/ part): Fructus Psoraleae 8 parts; Rhizoma Et Radix Notopterygii 10 parts; Radix Glycyrrhizae Preparata 11 parts; Radix Achyranthis Bidentatae 5 parts; To fail 7 parts, clothing; Herba Dendrobii 9 parts; Fructus Chaenomelis 11 parts; Ramulus Cinnamomi 11 parts; The Radix Paeoniae Alba 11 parts; Concha Haliotidis 9 parts; Radix Puerariae 13 parts; 5 parts, Rhizoma Gastrodiae; Fructus Viticis 6 parts.
The preparation method alleviating the external plaster application agent of shank sural spasm is:
(1) Concha Haliotidis is cleaned, and puts and smokeless stove fire is calcined to crisp, put and dry in the air, smash to pieces, for subsequent use; Fructus Psoraleae is placed under saline room temperature and soaks 13 hours, and take out, be placed in Chinese medicine pan, add the Oleum Brassicae campestris that mass fraction is 11%, slow fire heats, and fry and heaves to micro-, during savory effusion, taking-up cools, and it is for subsequent use to smash grinding to pieces;
(2) Ramulus Cinnamomi is cleaned, be placed in clear water and run through, shave; Get the refined honey of 0.16 times of Ramulus Cinnamomi amount, after thin up, drench in Ramulus Cinnamomi sheet, moistening, is then placed in frying pan, and slow fire heats, and fries to strong yellow, and tack-free is degree, and taking-up cools, and is ground into fine powder, for subsequent use; Radix Glycyrrhizae Preparata is ground into fine powder, for subsequent use;
(3) Fructus Chaenomelis and Fructus Viticis are placed in thermostatic drying chamber, first in 74 DEG C of dryings 16 minutes, then 48 DEG C of dryings 55 minutes are adjusted the temperature to, take out, be placed in Chinese medicine grinder and be ground into fine powder, the raw material medicated powder after processing with step (1) and step (2) mixes, and crosses 110 mesh sieves, obtain mixed powder, for subsequent use;
(4) Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, the Radix Paeoniae Alba, Radix Puerariae and Rhizoma Gastrodiae are together placed in Chinese medicinal pot, the pure water adding 8 times of material quantities soaks 2.0 hours, after medical material fully expands, and big fire heated and boiled 7 minutes, turn little fire to decoct 44 minutes, filter, medicinal residues add clear water and did not have powder 3-4cm, moderate heat heating decoction 18 minutes, filter, twice filter decocting liquid merges, and is again filtered by gained decocting liquid through three layers of cotton cloth, reduces the impurity in filtrate as far as possible;
(5) be the thick paste of 1.15-1.20 by step (4) gained filtrate reduced in volume to a 70 DEG C relative density, step (3) gained mixed powder is added in above-mentioned thick paste, camphorate simultaneously, Borneolum Syntheticum and azone (mass ratio of crude drug and Camphora, Borneolum Syntheticum and azone is 6: 1.7: 1.5: 1.3), blender rapid stirring is even, the metering uniform application pasted according to 16g/, on kraft paper, to obtain final product.
The using method of gained external plaster application agent of the present invention is: cleaned up in affected part, get this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.
Embodiment 4 alleviates the external plaster application agent of shank sural spasm, is prepared from by following raw material, is mass parts (30g/ part): Fructus Psoraleae 11 parts; Rhizoma Et Radix Notopterygii 14 parts; Radix Glycyrrhizae Preparata 13 parts; Radix Achyranthis Bidentatae 8 parts; To fail 8 parts, clothing; Herba Dendrobii 11 parts; Fructus Chaenomelis 13 parts; Ramulus Cinnamomi 14 parts; The Radix Paeoniae Alba 14 parts; Concha Haliotidis 11 parts; Radix Puerariae 17 parts; 8 parts, Rhizoma Gastrodiae; Fructus Viticis 9 parts.
The preparation method alleviating the external plaster application agent of shank sural spasm is:
(1) Concha Haliotidis is cleaned, and puts and smokeless stove fire is calcined to crisp, put and dry in the air, smash to pieces, for subsequent use; Fructus Psoraleae is placed under saline room temperature and soaks 17 hours, and take out, be placed in Chinese medicine pan, add the Oleum Brassicae campestris that mass fraction is 11%, slow fire heats, and fry and heaves to micro-, during savory effusion, taking-up cools, and it is for subsequent use to smash grinding to pieces;
(2) Ramulus Cinnamomi is cleaned, be placed in clear water and run through, shave; Get the refined honey of 0.19 times of Ramulus Cinnamomi amount, after thin up, drench in Ramulus Cinnamomi sheet, moistening, is then placed in frying pan, and slow fire heats, and fries to strong yellow, and tack-free is degree, and taking-up cools, and is ground into fine powder, for subsequent use; Radix Glycyrrhizae Preparata is ground into fine powder, for subsequent use;
(3) Fructus Chaenomelis and Fructus Viticis are placed in thermostatic drying chamber, first in 78 DEG C of dryings 18 minutes, then 52 DEG C of dryings 65 minutes are adjusted the temperature to, take out, be placed in Chinese medicine grinder and be ground into fine powder, the raw material medicated powder after processing with step (1) and step (2) mixes, and crosses 130 mesh sieves, obtain mixed powder, for subsequent use;
(4) Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, the Radix Paeoniae Alba, Radix Puerariae and Rhizoma Gastrodiae are together placed in Chinese medicinal pot, the pure water adding 10 times of material quantities soaks 3.0 hours, after medical material fully expands, and big fire heated and boiled 9 minutes, turn little fire to decoct 50 minutes, filter, medicinal residues add clear water and did not have powder 3-4cm, moderate heat heating decoction 28 minutes, filter, twice filter decocting liquid merges, and is again filtered by gained decocting liquid through three layers of cotton cloth, reduces the impurity in filtrate as far as possible;
(5) be the thick paste of 1.15-1.20 by step (4) gained filtrate reduced in volume to a 70 DEG C relative density, step (3) gained mixed powder is added in above-mentioned thick paste, camphorate simultaneously, Borneolum Syntheticum and azone (mass ratio of crude drug and Camphora, Borneolum Syntheticum and azone is 6: 1.7: 1.5: 1.3), blender rapid stirring is even, the metering uniform application pasted according to 19g/, on kraft paper, to obtain final product.
The using method of gained external plaster application agent of the present invention is: cleaned up in affected part, get this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.
Model case: Cui XX, female, 55 years old, with occurring both legs sural spasm pain after cold water foot bath before patient's readme half a year, after this show effect 10-15 time every day, outbreak focuses mostly at night, and pain can not be born, once treated at certain examination in hospital, took calcium preparation, the treatment such as Chinese medicine is without being clearly better.Talk about the worries of oneself when chatting with friend afterwards, someone recommends my institute to check treatment.Patient has the attitude of trying in arms, comes my institute check treatment on April 15th, 2010.Check: patient's blood calcium is normal, bilateral gastrocnemius protuberance and hard, shank can not stretch song, and both feet are weak, and white and greasy fur, stringy and rolling pulse is tight slightly, is diagnosed as shank sural spasm.
Use the present embodiment gained to alleviate the external plaster application agent of shank sural spasm, using method: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.After using two courses for the treatment of, patient obviously feels that spasm number of times reduces, during outbreak, pain obviously alleviates before comparatively treating, and after continuing two courses for the treatment of of use, patient's self-induction crus spasm disappears, the movable basic recovery of both feet is normal, and patient adheres to again employing a course for the treatment of with consolidate curative effect.Drug withdrawal is paid a return visit after half a year, without recurrence.
Embodiment 5 alleviates the external plaster application agent of shank sural spasm, is prepared from by following raw material, is mass parts (35g/ part): Fructus Psoraleae 9.5 parts; Rhizoma Et Radix Notopterygii 12 parts; Radix Glycyrrhizae Preparata 12 parts; Radix Achyranthis Bidentatae 6.5 parts; To fail 7.5 parts, clothing; Herba Dendrobii 10 parts; Fructus Chaenomelis 12 parts; Ramulus Cinnamomi 12.5 parts; The Radix Paeoniae Alba 12.5 parts; Concha Haliotidis 10 parts; Radix Puerariae 15 parts; 6.5 parts, Rhizoma Gastrodiae; Fructus Viticis 7.5 parts.
The preparation method alleviating the external plaster application agent of shank sural spasm is:
(1) Concha Haliotidis is cleaned, and puts and smokeless stove fire is calcined to crisp, put and dry in the air, smash to pieces, for subsequent use; Fructus Psoraleae is placed under saline room temperature and soaks 15 hours, and take out, be placed in Chinese medicine pan, add the Oleum Brassicae campestris that mass fraction is 11%, slow fire heats, and fry and heaves to micro-, during savory effusion, taking-up cools, and it is for subsequent use to smash grinding to pieces;
(2) Ramulus Cinnamomi is cleaned, be placed in clear water and run through, shave; Get the refined honey of 0.18 times of Ramulus Cinnamomi amount, after thin up, drench in Ramulus Cinnamomi sheet, moistening, is then placed in frying pan, and slow fire heats, and fries to strong yellow, and tack-free is degree, and taking-up cools, and is ground into fine powder, for subsequent use; Radix Glycyrrhizae Preparata is ground into fine powder, for subsequent use;
(3) Fructus Chaenomelis and Fructus Viticis are placed in thermostatic drying chamber, first in being preferable over 76 DEG C of dryings 17 minutes, then 50 DEG C of dryings 60 minutes are adjusted the temperature to, take out, be placed in Chinese medicine grinder and be ground into fine powder, the raw material medicated powder after processing with step (1) and step (2) mixes, and crosses 120 mesh sieves, obtain mixed powder, for subsequent use;
(4) Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, the Radix Paeoniae Alba, Radix Puerariae and Rhizoma Gastrodiae are together placed in Chinese medicinal pot, the pure water adding 9 times of material quantities soaks 2.5 hours, after medical material fully expands, and big fire heated and boiled 8 minutes, turn little fire to decoct 47 minutes, filter, medicinal residues add clear water and did not have powder 3-4cm, moderate heat heating decoction 23 minutes, filter, twice filter decocting liquid merges, and is again filtered by gained decocting liquid through three layers of cotton cloth, reduces the impurity in filtrate as far as possible;
(5) be the thick paste of 1.15-1.20 by step (4) gained filtrate reduced in volume to a 70 DEG C relative density, step (3) gained mixed powder is added in above-mentioned thick paste, camphorate simultaneously, Borneolum Syntheticum and azone (mass ratio of crude drug and Camphora, Borneolum Syntheticum and azone is 6: 1.7: 1.5: 1.3), blender rapid stirring is even, the metering uniform application pasted according to 18g/, on kraft paper, to obtain final product.
The using method of gained external plaster application agent of the present invention is: cleaned up in affected part, get this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.
Test example 1 gained of the present invention alleviates the clinical practice of the external plaster application agent (embodiment 5) of shank sural spasm:
1 data and method
1.1 physical data
In July ,-2013 in April, 2009, in 3 hospital screening crus spasm patients totally 286 examples, wherein male patient's totally 173 examples, female patient is totally 113 examples.The oldest 73 years old, at minimum 25 years old of age, the course of disease was the longest 5 years, the shortest 3 days.All patients all have paroxysmal one-sided or bilateral calf cramp, and local pain, lower limb can not stretch.All patients are divided into experimental group 183 people and matched group 103 people at random.Two groups of no significant difference in age and the state of an illness, the course of disease etc. (P > 0.05), have comparability.
1.2 Therapeutic Method
Experimental group takes the external plaster application agent that gained of the present invention alleviates shank sural spasm, and using method is: cleaned up in affected part, gets this patch of suitable size, heats softening, is attached to affected part, within 1 day, changes once, within 7 days, is a course for the treatment of.Treat 3 courses for the treatment of altogether.Matched group uses other products conventional medication such as () you are strange for anti-cramp in the leg high calcium tablet, calcium, Yunnan Baiyao aerosols.
1.3 efficacy assessment standard
Cure: shank sural spasm disappears completely, can normal activity, drug withdrawal after three months without recurrence; Effective: shank sural spasm obviously alleviates, movable normal; Invalid: crus spasm pain is without improvement.(effective percentage=cure rate+obvious effective rate)
1.4 therapeutic outcome
Clinical efficacy comparison after two groups of patient treatments, as shown in table 1.
Table 1: the therapeutic outcome of experimental group and matched group patient
Therapeutic outcome: experimental group cures 135 examples (73.8%) altogether, effective 45 examples (24.6%), invalid 3 examples (1.6%), effective percentage is 98.4%, the effective percentage of matched group is 80.6%, and the therapeutic effect of experimental group is obviously better than matched group.
The present invention select Fructus Psoraleae, Rhizoma Et Radix Notopterygii, Radix Glycyrrhizae Preparata, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, Fructus Chaenomelis, Ramulus Cinnamomi, the Radix Paeoniae Alba, Concha Haliotidis, Radix Puerariae, Rhizoma Gastrodiae and Fructus Viticis totally 13 taste primary raw material medicines be prepared from.Fang Zhong, Rhizoma Et Radix Notopterygii has cold expelling, dispels the wind, dehumidifying, effect of pain relieving; Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation; To fail clothing wind-damp dispelling; Disappear sore; Herba Dendrobii promotes the production of body fluid stomach reinforcing, clearing away heat and nourishing YIN; Fructus Chaenomelis suppressing the hyperactive liver and easing the stomach, dry relaxing muscles and tendons; Ramulus Cinnamomi diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI; The Radix Paeoniae Alba has suppressing the hyperactive liver pain relieving, the effect of nourishing blood for regulating menstruation, dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin etc.; Concha Haliotidis suppressing the hyperactive liver and subsiding YANG, liver heat removing and eyesight improving; Rhizoma Gastrodiae returns Liver Channel, relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral; Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.The all medicines of we share, and can mutually adjust, and strengthen suppressing the hyperactive liver pain relieving, endogenous wind stopping relieving convulsion, effect of promoting the flow of QI-blood by warming the meridian.Experimental group treats three courses for the treatment of, and effective percentage is 98.4%, and successful is better than matched group.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. alleviate the external plaster application agent of shank sural spasm, it is characterized in that, be prepared from by following raw material, be mass parts: Fructus Psoraleae 7-12; Rhizoma Et Radix Notopterygii 8-16; Radix Glycyrrhizae Preparata 9-15; Radix Achyranthis Bidentatae 4-9; Fail clothing 6-9; Herba Dendrobii 8-12; Fructus Chaenomelis 9-15; Ramulus Cinnamomi 10-15; Radix Paeoniae Alba 10-15; Concha Haliotidis 8-12; Radix Puerariae 10-20; Rhizoma Gastrodiae 4-9; Fructus Viticis 5-10.
2. the external plaster application agent alleviating shank sural spasm as claimed in claim 1, is characterized in that, be prepared from, be mass parts by following raw material: Fructus Psoraleae 8-11; Rhizoma Et Radix Notopterygii 10-14; Radix Glycyrrhizae Preparata 11-13; Radix Achyranthis Bidentatae 5-8; Fail clothing 7-8; Herba Dendrobii 9-11; Fructus Chaenomelis 11-13; Ramulus Cinnamomi 11-14; Radix Paeoniae Alba 11-14; Concha Haliotidis 9-11; Radix Puerariae 13-17; Rhizoma Gastrodiae 5-8; Fructus Viticis 6-9.
3. the external plaster application agent alleviating shank sural spasm as claimed in claim 1, is characterized in that, be prepared from, be mass parts by following raw material: Fructus Psoraleae 9.5; Rhizoma Et Radix Notopterygii 12; Radix Glycyrrhizae Preparata 12; Radix Achyranthis Bidentatae 6.5; To fail clothing 7.5; Herba Dendrobii 10; Fructus Chaenomelis 12; Ramulus Cinnamomi 12.5; The Radix Paeoniae Alba 12.5; Concha Haliotidis 10; Radix Puerariae 15; Rhizoma Gastrodiae 6.5; Fructus Viticis 7.5.
4. the preparation method of the external plaster application agent of the alleviation shank sural spasm as described in claim 1-3, it is characterized in that, step is as follows:
(1) Concha Haliotidis is cleaned, and puts and smokeless stove fire is calcined to crisp, put and dry in the air, smash to pieces, for subsequent use; Fructus Psoraleae soaks under being placed in saline room temperature 10-20 hour (soaking 13-17 hour under preferred room temperature), takes out, is placed in Chinese medicine pan, add the Oleum Brassicae campestris that mass fraction is 11%, slow fire heats, and fries and heaves to micro-, during savory effusion, taking-up cools, smash to pieces grind for subsequent use;
(2) Ramulus Cinnamomi is cleaned, be placed in clear water and run through, shave; Get the refined honey (preferably getting the refined honey of 0.18 times of Ramulus Cinnamomi amount) of 0.15-0.20 times of Ramulus Cinnamomi amount, after thin up, drench in Ramulus Cinnamomi sheet, moistening, then be placed in frying pan, slow fire heats, and fries to strong yellow, and tack-free is degree, taking-up cools, and is ground into fine powder, for subsequent use; Radix Glycyrrhizae Preparata is ground into fine powder, for subsequent use;
(3) Fructus Chaenomelis and Fructus Viticis are placed in thermostatic drying chamber, first in 72-80 DEG C of dry 14-20 minute (being preferable over 74-78 DEG C of dry 16-18 minute), then adjust the temperature to 45-55 DEG C of dry 50-70 minute (preferably adjusting the temperature to 48-52 DEG C of dry 55-65 minute), take out, be placed in Chinese medicine grinder and be ground into fine powder, the raw material medicated powder after processing with step (1) and step (2) mixes, and sieves, obtain mixed powder, for subsequent use;
(4) Rhizoma Et Radix Notopterygii, Radix Achyranthis Bidentatae, clothing of failing, Herba Dendrobii, the Radix Paeoniae Alba, Radix Puerariae and Rhizoma Gastrodiae are together placed in Chinese medicinal pot, add pure water to soak, after medical material fully expands, big fire heated and boiled 6-10 minute (preferred big fire heated and boiled 8 minutes), turn little fire and decoct 36-58 minute, filter, medicinal residues add clear water and did not have powder 3-4cm, and moderate heat heating decocts 12-34 minute, filter, twice filter decocting liquid merges, and is again filtered by gained decocting liquid through three layers of cotton cloth, reduces the impurity in filtrate as far as possible;
(5) be the thick paste of 1.15-1.20 by step (4) gained filtrate reduced in volume to a 70 DEG C relative density, step (3) gained mixed powder is added in above-mentioned thick paste, camphorate simultaneously, Borneolum Syntheticum and azone, blender rapid stirring is even, metering (preferably according to the metering that the 18g/ pastes) uniform application pasted according to 15-20g/, on kraft paper, to obtain final product.
5. the preparation method of the external plaster application agent of alleviation shank sural spasm according to claim 4, is characterized in that, the middle 90-150 mesh sieve excessively of step (3) (preferred 110-130 mesh sieve excessively, mistake 120 mesh sieve be more preferably).
6. the preparation method of the external plaster application agent of alleviation shank sural spasm according to claim 4, it is characterized in that, the pure water (preferably adding the pure water of 8-10 times of material quantity, the pure water adding 9 times of material quantities be more preferably) of 6-12 times of material quantity is added in step (4).
7. the preparation method of the external plaster application agent of alleviation shank sural spasm according to claim 4, it is characterized in that, the time of soaking in step (4) is 1.6-3.4 hour (the preferred time of soaking is 2.0-3.0 hour, and the time of the immersion be more preferably is 2.5 hours).
8. the preparation method of the external plaster application agent of alleviation shank sural spasm according to claim 4, is characterized in that, the medium and small fire of step (4) decocts 44-50 minute (preferred little fire decocts 47 minutes).
9. the preparation method of the external plaster application agent of alleviation shank sural spasm according to claim 4, is characterized in that, in step (4), moderate heat heating decocts 18-28 minute (preferred moderate heat heating decoction 23 minutes).
10. the preparation method of the external plaster application agent of alleviation shank sural spasm according to claim 4, is characterized in that, the mass ratio of step (5) Raw medicine and Camphora, Borneolum Syntheticum and azone is 6: 1.7: 1.5: 1.3.
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Cited By (1)
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| CN110755462A (en) * | 2019-11-22 | 2020-02-07 | 江西佰康药业有限责任公司 | External spray for treating gastrocnemius spasm and preparation method thereof |
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| CN104491250A (en) * | 2014-12-31 | 2015-04-08 | 天津市聚升鑫科技发展有限公司 | Medicine for treating leg cramps and preparation method |
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| CN104491250A (en) * | 2014-12-31 | 2015-04-08 | 天津市聚升鑫科技发展有限公司 | Medicine for treating leg cramps and preparation method |
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| CN110755462A (en) * | 2019-11-22 | 2020-02-07 | 江西佰康药业有限责任公司 | External spray for treating gastrocnemius spasm and preparation method thereof |
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Address after: Chengguan District of Gansu city of Lanzhou province Donggang road 730000 No. 923 Donggang District 3 2-101 Applicant after: Wang Dongmei Address before: Hualong Road, Licheng District, Shandong city of Ji'nan Province, 250000 No. 3 Ginza Garden Applicant before: Wang Dongmei |
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Application publication date: 20150819 |