CN104840599B

CN104840599B - A kind of medicine for treating ankylosing spondylitis

Info

Publication number: CN104840599B
Application number: CN201510286495.3A
Authority: CN
Inventors: 李小敬
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-05-30
Filing date: 2015-05-30
Publication date: 2018-03-27
Anticipated expiration: 2035-05-30
Also published as: CN104840599A

Abstract

Main to include for oral administration, two groups of medicines of external application the present invention relates to a kind of medicine for treating ankylosing spondylitis, wherein medicine for oral administration forms：Semen Cuscutae 15g, fry dipsacus root 15g, stir-baked CORTEX EUCOMMIAE 10g, cultivated land 10g, dogwood fruit 10g, rhizoma cibotii 15g, Ramulus Taxilli 15g, radix cyathulae 15g, psoralea corylifolia 10g, cassia twig 15g, fruit of glossy privet 8g, Eclipta prostrata 8g, Radix Angelicae Sinensis 15g, peach kernel 15g, root of herbaceous peony 30g, radix glycyrrhizae 6g.Daily 1 dose, it is decocted in water for oral dose.External used medicine forms：Notopterygium root 15g, cassia twig 15g, Sargent gloryvine 15g, lycopodium calvatum 15g, lopseed 15g, bush 8g, caulis trachelospermi 10g, coix seed 30g.Patient lies supine adds to decoct in water and fumigated in steaming on bed.Present invention treatment ankylosing spondylitis is inside and outside to combine, and treats both principal and secondary aspect of disease, and especially treating kidney deficiency and liver card ankylosing spondylitis has obvious efficiency.

Description

A kind of medicine for treating ankylosing spondylitis

Technical field

The present invention relates to technical field of traditional Chinese medicines, specifically a kind of medicine for treating ankylosing spondylitis.

Background technology

Ankylosing spondylitis is clinical common chronic inflammation disease, mainly to invade backbone apophysis, articulatio sacroiliaca, ridge With the characteristics of post side soft tissue and periphery joint, its incidence of occult, patient engenders the small of the back or sacroiliac severe pain more, living Mitigate after dynamic, the sustainable several months, misdiagnosis or mistake, which are controlled, can cause deformity of spine and tetanic lesion, have a strong impact on the life matter of patient Amount.Modern medical therapy is based on the drug therapies such as nonsteroidal anti-inflammatory drug, it is intended to relief of symptoms, symptom management, prevents that joint is abnormal Shape.But certain adverse reaction with it long be present, especially upset,gastro-intestinal serious symptom, it is heavy then cause ulcer bleeding, perforation, Marrow suppression, dysfunction of liver etc.^[1].Comparatively speaking, Enema compress opinion is controlled and can learnt from other's strong points to offset one's weaknesses, and has rapid-action, adverse reaction Less, ask this except advantage and characteristics such as roots.

The content of the invention

It is an object of the invention to provide a kind of medicine for treating ankylosing spondylitis.In Chinese medicine preparation of the present invention uses Clothes, fumigate to combine and patients with ankylosing spondylitis is treated, effectively solve patient articular's pain, the influence of inflammatory factor.

The technical scheme is that：A kind of medicine for treating ankylosing spondylitis, it is main to include for oral administration, two groups of medicines of external application Thing, wherein medicine for oral administration form：Semen Cuscutae 15g, fry dipsacus root 15g, stir-baked CORTEX EUCOMMIAE 10g, cultivated land 10g, dogwood fruit 10g, rhizoma cibotii 15g, mulberry Parasitic 15g, radix cyathulae 15g, psoralea corylifolia 10g, cassia twig 15g, fruit of glossy privet 8g, Eclipta prostrata 8g, Radix Angelicae Sinensis 15g, peach kernel 15g, the root of herbaceous peony 30g, radix glycyrrhizae 6g.Daily 1 dose, it is decocted in water for oral dose.External used medicine forms：Notopterygium root 15g, cassia twig 15g, Sargent gloryvine 15g, lycopodium calvatum 15g are deep Careless 15g, bush 8g, caulis trachelospermi 10g, coix seed 30g.Patient lies supine takes top to be fitted into gauze medicine bag and is put into entirely in steaming on bed Automatic fumigation dipping instrument, adds in water and decocts, and affected part face is fumigated into window, and temperature is kept for 40 DEG C or so, one time a day, smoked every time Steam half an hour.During treatment, take orally, be stifling with using, 1 month is 1 course for the treatment of, and two groups are used continuously 3 months.

Ankylosing spondylitis is a kind of chronic inflammation rheumatic disease, belongs to traditional Chinese medicine " numbness disease " category, have again " heumatism ", " big crooked ", the title of " ring wind ".Patient clinical is more to be chief complaint with waist sacrum back pain, arthralgia, joint joint stuffiness etc., therefore Alleviation, the improvement of function of joint of joint pain are the primary aspects of clinical appraisal curative effect.Modern medicine study is thought, tatanic Rachitis is the chronic inflammation disease that one kind of multiple factors participate in jointly, and definite pathogenesis is still indefinite, but with heredity, The factors such as Non-adhesion inhibition index, immune, bacterium infection are closely related.In recent years, the biological characteristics of inflammatory cytokine, its The relation between effect and its pathogenesis and disease activity played in the inflammatory process of autoimmune disease turns into The important target spot of clinic concern^[5].As TNF-α be in inflammatory process earliest caused by one of cell factor, body inflammatory reacts Its horizontal rise in local joint and serum can be caused, there is a variety of inflammatories and immune response activity, can by induce because The approach such as son activation participate in the destruction of bone in joint and the inflammatory damage of surrounding tissue.IL-6 is high expression before a kind of fibrosis Cell factor, with inflammation fall ill it is closely related, in recent years using its for targeting medicine to disease incidence mechanism illustrate and clinic Treatment has most important theories meaning and application value.In terms for the treatment of, combination of Chinese tradiational and Western medicine opinion tool treats both principal and secondary aspect of disease, be rapid-action, The advantage of few side effects.The author's clinical findings patient using kidney deficiency and liver card be it is more, with reference to《Plain Questions is to will very discuss greatly》Say " too Sun in spring, tremble with fear it is multiple in remaining, then lumbosacral pain, joint stuffiness, pain in stock shin foot knee " visible liver-kidney deficiency for its morbidity this.The traditional Chinese medical science There are " waist is house of kidney ", " the kidney generating marrow and dominating bone ", the theory of " liver storing blood cage bar ", patient Duo Yin native endowments deficiency, ferritic are empty Weak, it is improper to take good care of oneself the day after tomorrow in addition, causes body asthenia of essence and blood, causes bone to become homeless foster, and liver body, which loses, supports, so grain lose it is flourish, muscles and bones delay it is weak, Wind-cold damp pathogen is taken advantage of a weak point morbidity.Therefore the palpus kidney-nourishing strengthening tendons, dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels controlled.With reference to its pathogenic characteristic, Bi Zhexuan Select external therapy in the traditional Chinese medical science and share and control it.Traditional Chinese medicine for oral administration is authors'several years Empirical formula, focuses on kidney-boosting tonic.Semen Cuscutae, stir-fry river in side Disconnected, stir-baked CORTEX EUCOMMIAE focuses on kidney-nourishing gas, the work(for having kidney-nourishing strengthening tendons；Cultivated land, dogwood fruit, the fruit of glossy privet, Eclipta prostrata work(are filling up kidney essense, to fill Nourishing the bone marrow；Rhizoma cibotii is longer than the strong ridge of strong bone, the good medicine that main back is strong, wind is empty；Ramulus Taxilli is liver and kidney benefiting, wind-dispelling, the good medicine of strengthening the bones and muscles； Radix cyathulae work(has row in filling liver kidney, invigorate blood circulation, bowl spares；Psoralea corylifolia focuses on warm kidney sun, and matching with cassia twig can dispelling wind and eliminating dampness, nourshing kidney Establishing-Yang, warming yang for activating qi-flowing；Chinese Angelica blood replonishing is invigorated blood circulation；Peach kernel is longer than promoting blood circulation and breaking stagnation analgesic；The soft liver of root of herbaceous peony nourishing liver, stop with radix glycyrrhizae compatibility emergency Bitterly.Multiple medicine compatibility, based on benefit, supplemented by logical, bowl spares has row, plays kidney-nourishing strengthening tendons, the effect of promoting blood circulation and stopping pain altogether.In addition, traditional Chinese medicine fumigating It is to stimulate affected part skin opening of the pores using the warm of medicine to steam as external therapy, and drug effect guides drugs to illness station, and has good absorbing, effect Directly, the advantages that rapid-action.Moreover, medicament fumigating is beneficial to promote local affected part blood circulation, is closed with easing joint movement, alleviation Save pain, have " by table it is saturating in ", " inner disease outer treat ", " sweat defended without hindering battalion " the characteristics of.Smoked wash focuses on that easing joint movement, promoting blood circulation is logical Network, medicine notopterygium wind dispelling dehumidifying, are removed obstruction in channels to relieve pain based on taste bitter and cold；Cassia twig can promoting blood circulation joint, have supporing yang cold dispelling, OK The effect of gas analgesic；Sargent gloryvine is longer than promoting blood circulation by removing wind, promoting qi circulation and relieving pain；Lopseed, lycopodium calvatum work(can active relaxing muscles and tendons, damp-clearing pain-relievings；Bush Be longer than it is promoting blood circulation and removing blood stasis, remove obstruction in channels to relieve pain；Caulis trachelospermi is good at degrading the channel promoting blood circulation, is specially in the good medicine of relaxing tendons and activating collaterals；Coix seed work(can Heat-clearing eliminating impediment after invigorating the spleen.Multiple medicine compatibility, dispelling wind and eliminating dampness, the effect for eliminating impediment of invigorating blood circulation are played altogether.

Present invention treatment ankylosing spondylitis is inside and outside to combine, and treats both principal and secondary aspect of disease, and especially treats kidney deficiency and liver and demonstrate,proves tatanic ridge Post inflammation has obvious efficiency.

Embodiment

With reference to embodiment, the invention will be further described.

Embodiment：A kind of medicine for treating ankylosing spondylitis, it is main to include for oral administration, two groups of medicines of external application, wherein for oral administration Medicine forms：Semen Cuscutae 15g, fry dipsacus root 15g, stir-baked CORTEX EUCOMMIAE 10g, cultivated land 10g, dogwood fruit 10g, rhizoma cibotii 15g, Ramulus Taxilli 15g, river ox Knee 15g, psoralea corylifolia 10g, cassia twig 15g, fruit of glossy privet 8g, Eclipta prostrata 8g, Radix Angelicae Sinensis 15g, peach kernel 15g, root of herbaceous peony 30g, radix glycyrrhizae 6g.Daily 1 dose, it is decocted in water for oral dose.External used medicine forms：Notopterygium root 15g, cassia twig 15g, Sargent gloryvine 15g, lycopodium calvatum 15g, lopseed 15g, bush 8g, network Stone rattan 10g, coix seed 30g.Patient lies supine takes top to be fitted into gauze medicine bag and is put into automatically stifling dipping instrument in steaming on bed Device, add in water and decoct, affected part face is fumigated into window, temperature is kept for 40 DEG C or so, one time a day, fumigates half an hour every time.Treatment When, take orally, be stifling with using, 1 month is 1 course for the treatment of, and two groups are used continuously 3 months.

Clinical data

1st, basic document.

The patients with ankylosing spondylitis 74 that in January, 2013 in November, 2014 is gone to a doctor in our hospital, is randomly divided into control Group and each 37 of observation group patient.Control group man 27, female 10；24 ~ 45 years old age, average age（29.7±2.5）Year；Disease Journey -13 years 5 months, average course of disease（5.8±1.3）Year；Observation group man 31, female 6；23 ~ 43 years old age, average age （28.5±2.4）Year；The course of disease -11 years 6 months, average course of disease（5.4±1.7）Year；The sex of two groups of patients, age, course of disease etc. General information is statistically analyzed, no statistical difference difference（P>0.05）, there is comparativity between illustrating two groups.

2nd, diagnostic criteria.

Tcm diagnosis reference《New Chinese medicine guideline of clinical investigations》In relevant kidney deficiency and liver card ankylosing spondylitis Diagnostic criteria is made a definite diagnosis.Patient clinical draws a ridge buttocks with pain in the back and carried on the back, and stiff deformity, wasting and atrophy of muscle, joint stuffiness, hand is not warm, fear Cold happiness is warm, or soreness and weakness of waist and knees, involuntary emission, and impotence etc., tongue nature is light, tongue Bai Shaojin, forceless deep pulse or counts accurately.

3rd, treatment method.

Control group:It is general to give Western medicine benefit match（Chinese medicines quasi-word：S20050058, enterprise：Upper marine letter state, which is good for medicine company share, to be had Limit company, specification：12.5mg/ bottles）It is subcutaneously injected, each 25mg, 2 times a week, every minor tick 3-4 days, with 1 milliliter of note before injection Penetrate and dissolved with water, closed environment can refrigerate 72 hours in 2-8 DEG C after dissolving.

Observation group:Taken orally to a kind of medicine for treating ankylosing spondylitis of the present invention, stifling therapeutic alliance.It is for oral administration：Tu silks Sub- 15g, fry dipsacus root 15g, stir-baked CORTEX EUCOMMIAE 10g, cultivated land 10g, dogwood fruit 10g, rhizoma cibotii 15g, Ramulus Taxilli 15g, radix cyathulae 15g, Psoralen Fat 10g, cassia twig 15g, fruit of glossy privet 8g, Eclipta prostrata 8g, Radix Angelicae Sinensis 15g, peach kernel 15g, root of herbaceous peony 30g, radix glycyrrhizae 6g.Daily 1 dose, decocting Clothes.2. stifling side is as follows：Notopterygium root 15g, cassia twig 15g, Sargent gloryvine 15g, lycopodium calvatum 15g, lopseed 15g, bush 8g, caulis trachelospermi 10g, Coix seed 30g.Patient lies supine takes top to be fitted into gauze medicine bag and is put into automatically stifling dipping instrument, add in water in steaming on bed Decoct, affected part face is fumigated into window, temperature is kept for 40 DEG C or so, one time a day, fumigates half an hour every time.

1 month is 1 course for the treatment of, and two groups continuously treatment observes curative effect after 3 months.

4th, therapeutic evaluation.

Recovery from illness：Patient symptom disappears, and joint, spinal function activity recover normal；It is effective：Symptom is relieved, joint, ridge The increase of post functional activity scope；Effectively：Symptom mitigates substantially, and joint, spinal function scope of activities have increased slightly；It is invalid：Symptom And joint, spinal function activity are unchanged.

5th, Comparison of therapeutic.

The symptoms such as patient's back after treatment is stiff, joint stuffiness are relieved, the effective percentage 70.3% of control group, are relatively seen Examining group effective percentage 91.9% substantially reduces, and difference is statistically significant（P ＜ 0.05）.It is shown in Table 1.

1 two groups of patients with ankylosing spondylitis clinical efficacy contrasts of table（Example）

Group	n	Cure	It is effective	Effectively	It is invalid	It is efficient（%）
							Control group	37	5	6	15	11	70.3
Observation group	37	13	11	10	3	91.9^a

Conclusion：A kind of tatanic ridge of for oral administration, the stifling therapeutic alliance of Chinese medicine composition for treating ankylosing spondylitis of the present invention Post inflammation significant effect, better than prior art.

Claims

A kind of 1. medicine for treating ankylosing spondylitis, it is characterised in that it is main to include for oral administration, two groups of medicines of external application, wherein interior Medication composition：Semen Cuscutae 15g, fry dipsacus root 15g, stir-baked CORTEX EUCOMMIAE 10g, cultivated land 10g, dogwood fruit 10g, rhizoma cibotii 15g, Ramulus Taxilli 15g, river Root of bidentate achyranthes 15g, psoralea corylifolia 10g, cassia twig 15g, fruit of glossy privet 8g, Eclipta prostrata 8g, Radix Angelicae Sinensis 15g, peach kernel 15g, root of herbaceous peony 30g, radix glycyrrhizae 6g；Outside Formed with medicine：Notopterygium root 15g, cassia twig 15g, Sargent gloryvine 15g, lycopodium calvatum 15g, lopseed 15g, bush 8g, caulis trachelospermi 10g, Job's tears Benevolence 30g；Patient lies supine takes above-mentioned external used medicine to be fitted into gauze medicine bag and is put into automatically stifling dipping instrument, add in steaming on bed Decocted in water, affected part face is fumigated into window, temperature is kept for 40 DEG C or so, one time a day, fumigates half an hour every time.