CN104825732A

CN104825732A - Traditional Chinese medicine composition for treating palpitaition

Info

Publication number: CN104825732A
Application number: CN201510221766.7A
Authority: CN
Inventors: 田丽华
Original assignee: Zibo Qidingli Patent Information Consulting Co Ltd
Current assignee: Zibo Qidingli Patent Information Consulting Co Ltd
Priority date: 2015-05-05
Filing date: 2015-05-05
Publication date: 2015-08-12

Abstract

The invention provides a traditional Chinese medicine composition for treating palpitaition. The traditional Chinese medicine composition is prepared from the following raw materials: radix astragali, radix codonopsis, Chinese yam, licorice and the like. The traditional Chinese medicine composition provided by the invention can be used for treating palpitaition.

Description

A kind of Chinese medicine composition being used for the treatment of cardiopalmus

Technical field

The present invention relates to technical field of traditional Chinese medicine preparation, be specifically related to a kind of Chinese medicine composition being used for the treatment of cardiopalmus and its preparation method and application.

Background technology

Cardiopalmus is become homeless by the heart to support or heresy disturbs the mind, and cause heart beating abnormal, conscious nervous uneasy disease of palpitating from nervousness, is more common in heart neurosis and arrhythmia.Because sickness rate is high, for this reason, be bursting to and develop the needs that more medicines for the treatment of cardiopalmus safely and effectively meet clinical treatment.

Summary of the invention

In order to solve the problem, the object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of cardiopalmus disease.In order to reach this object, adopt following technical scheme:

Technical scheme: a kind of Chinese medicine composition being used for the treatment of cardiopalmus, the active component contained by it is extracted by following weight crude drug and is prepared from: Suffrutescent Securinega Twig 12 parts, Herba Boenninghauseniae 10 parts, Radix Codonopsis 10 parts, the Radix Astragali 18 parts, Poria cum Radix Pini 10 parts, Radix Angelicae Sinensis 10 parts, Flos Albiziae 15 parts, Radix Bupleuri 6 parts, Fructus Aurantii 10 parts, Flos Rosae Rugosae 3 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Polygalae 8 parts, Semen Ziziphi Spinosae 18 parts, the Radix Aucklandiae 5 parts, Rhizoma Dioscoreae 12 parts, 3 parts, Radix Glycyrrhizae.

The described Chinese medicine composition being used for the treatment of cardiopalmus, dosage form is pharmaceutically acceptable granule, tablet, capsule.

The described Chinese medicine composition being used for the treatment of cardiopalmus, preparation process is: get above-mentioned Chinese medicine, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add adjuvant and make capsule, tablet, granule.

The described application of Chinese medicine composition in preparation treatment cardiopalmus medicine being used for the treatment of cardiopalmus.

Suffrutescent Securinega Twig, Latin is called Flueggea suffruticosa (Pall.) Baill., is the defoliation bush plant under Euphorbiaceae.China originates in plants, and there is wild distribution North China, and also there is growth northeast, Central China, East China, southwest, the Northwest.Expelling wind and activating blood circulation, the strong muscle of the kidney invigorating.For facial paralysis, poliomyelitis sequela, dizzy, deaf, neurasthenia, lethargy, sexual impotence.

Herba Boenninghauseniae is the herb of Rutaceae pine wind grass platymiscium Herba Boenninghauseniae Boenninghausenia sessilicarpa Levl..Autumn extracts herb, and clean cutting is dried.Heat-clearing and toxic substances removing, promoting blood circulation and stopping pain.For flu, tonsillitis, parotitis, bronchitis, stomachache abdominal distention, thromboangiitis obliterans, lumbago, traumatic injury.All the other Chinese medicines are pharmacopeia kind.

Beneficial effect: the present invention treats cardiopalmus successful.

Detailed description of the invention

Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.

1, the preparation of granule embodiment: get Suffrutescent Securinega Twig 12g, Herba Boenninghauseniae 10g, Radix Codonopsis 10g, Radix Astragali 18g, Poria cum Radix Pini 10g, Radix Angelicae Sinensis 10g, Flos Albiziae 15g, Radix Bupleuri 6g, Fructus Aurantii 10g, Flos Rosae Rugosae 3g, Rhizoma Atractylodis Macrocephalae 10g, Radix Polygalae 8g, Semen Ziziphi Spinosae 18g, Radix Aucklandiae 5g, Rhizoma Dioscoreae 12g, Radix Glycyrrhizae 3g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, make granule.

2, the preparation of Tablets Example: get Suffrutescent Securinega Twig 12g, Herba Boenninghauseniae 10g, Radix Codonopsis 10g, Radix Astragali 18g, Poria cum Radix Pini 10g, Radix Angelicae Sinensis 10g, Flos Albiziae 15g, Radix Bupleuri 6g, Fructus Aurantii 10g, Flos Rosae Rugosae 3g, Rhizoma Atractylodis Macrocephalae 10g, Radix Polygalae 8g, Semen Ziziphi Spinosae 18g, Radix Aucklandiae 5g, Rhizoma Dioscoreae 12g, Radix Glycyrrhizae 3g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add dextrin 50g, granulate, tabletting, make tablet.

3, the preparation of capsule embodiment: get Suffrutescent Securinega Twig 12g, Herba Boenninghauseniae 10g, Radix Codonopsis 10g, Radix Astragali 18g, Poria cum Radix Pini 10g, Radix Angelicae Sinensis 10g, Flos Albiziae 15g, Radix Bupleuri 6g, Fructus Aurantii 10g, Flos Rosae Rugosae 3g, Rhizoma Atractylodis Macrocephalae 10g, Radix Polygalae 8g, Semen Ziziphi Spinosae 18g, Radix Aucklandiae 5g, Rhizoma Dioscoreae 12g, Radix Glycyrrhizae 3g, add the water of medical material 10 times of weight, soak 0.5h, decoct 1 hour, filter, medicinal residues add the water of medical material 8 times of weight again, decoct 1 hour, medicinal liquid leaches, merge twice decoction liquor, being evaporated to 60 DEG C of relative densities is 1.05, adding ethanol makes the percent by volume of alcohol content reach 75%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 90 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 10ml/s, add starch 50g, granulate, fill, make capsule.

4, traditional Chinese medicine composition for treating cardiopalmus of the present invention clinical research

4.1 general data: this Chinese medicine composition is applied to clinical observation cardiopalmus case 60 example, and at 38 ~ 65 years old age, men and women half and half, the shortest person of the course of disease 1 month, and most elder reaches 2 years, average 1 year half.

4.2 diagnostic criterias:

4.2.1 conscious heartbeat is abnormal, quick or slow, or it is overweight to beat, or suddenly only neglects jumping.In paroxysmal or continue do not understand, nervous, say in mind uneasiness.

4.2.2 with discomfort uncomfortable in chest, vexed difference of sleeping, trembles weak, dizzy grade for disease.Middle-older patient, can with ambition pain, very then dyspnea with rapid and short breath, cold extremities due to sweating, or sees and faint.

4.2.3 number, short, knot, generation, the pulse condition such as slow, slow as seen.

4.2.4 often emotional stimulation is had, in terror, nervous, overstrain, the risk factor such as to drink.

4.2.5 routine blood test, erythrocyte sedimentation rate, anti-" O ", T3, T4 and electrocardiogram, the inspections such as x-ray chest radiography, measuring blood pressure, help and clarify a diagnosis.

4.2.6 syndrome-classification

4.2.6.1 timidness due to deficiency of the heart: cardiopalmus is sent out, uneasiness of palpitating from nervousness, spontaneous perspiration of breathing hard because of terrified, god is tired weak, little sleep disturbed by dreams.Light red tongue, white and thin fur, thready and stringy pulse.

4.2.6.2 deficiency of both the heart and spleen: palpitation and restlessness, insomnia forgetfulness, complexion huang (all of a sudden) is white, and dizzy weak, easy antiperspirant of breathing hard, anorexia is uncomfortable in chest.Light red tongue, white and thin fur, weak pulse.

4.2.6.3 hyperactivity of fire caused by deficiency of YIN: palpitation and uneasiness, ponder over and work with one's mind more so, in the heart dysphoria with smothery sensation, little sleep disturbed by dreams, have a dizzy spell, tinnitus, xerostomia, buccal is warmed.Red tongue, yellow and thin fur, thready pulse stringy and rapid pulse.

4.2.6.4 stagnation of heart-blood: cardiopalmus severe palpitation, pained paroxysm uncomfortable in chest, or face purple lip is dark.The purple gas of body of the tongue or have ecchymosis, thready and hesitant pulse or knot generation.

4.2.6.5 the heart attacked by pathogenic water: endlessly, asthma uncomfortable in chest, coughs and tell a large amount of foam sputum, puffiness of the face and dropsy of the feet, can not put down sleeping severe palpitation, dizzy, oliguria.Tongue is greasy or whiten in vain, stringy and rolling pulse number disease.

4.2.6.6 heart-yang is weak: cardiopalmus is dynamic is then very, sensation of oppression over the chest with shortness of breath, aversion to cold and cold limbs, dizzy, pale complexion.Light red tongue is fat, and tongue is white, and deep-thready pulse is slow or tie generation.

4.3 test methods: prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing.Blank group oral placebo granule five days is a course for the treatment of, one day three bags, point early, middle and late three half an hour ante cibum take.

4.4 criterions of therapeutical effect: cure: symptom and arrhythmia disappear, the lab testings such as electrocardiogram recover normal.Take a turn for the better: symptom alleviates or the intermittent time of showing effect extends, and lab testing is improved.Invalid: symptom and arrhythmia unchanged.

4.5 therapeutic effect: in table 1.

Table 1 liang group comparitive study

Group	n	Cure	Take a turn for the better	Invalid	Total effective rate (%)
						Treatment group	30	15	12	3	90
Blank group	30	1	1	18	6.7

Visible the present invention has good therapeutic effect to cardiopalmus, and toxic and side effects does not occur treatments period.

4.6 model cases:

Often certain, male, 58 years old, and conscious heartbeat is abnormal, fast or slow, nervous, says in mind uneasiness, and with ambition pain, very then dyspnea with rapid and short breath, cold extremities due to sweating, insomnia forgetfulness, complexion is white all of a sudden, and dizzy weak, easy antiperspirant of breathing hard, anorexia is uncomfortable in chest.Light red tongue, white and thin fur, weak pulse.Be diagnosed as deficiency of both the heart and spleen, take and prepare clinical sample by above-mentioned process for producing granula, specification is 10 grams every bag, within five days, is a course for the treatment of, one day three bags, take point early, middle and late three half an hour ante cibum.Period in a medicine is avoided eating anything raw or cold, pungent, stimulate and rotten thing, after ten days, symptom and arrhythmia disappear, and the lab testings such as electrocardiogram recover normally.

Claims

1. one kind is used for the treatment of the Chinese medicine composition of cardiopalmus, it is characterized in that, the active component contained by it is extracted by following raw materials in part by weight medicine and is prepared from: Suffrutescent Securinega Twig 12 parts, Herba Boenninghauseniae 10 parts, Radix Codonopsis 10 parts, the Radix Astragali 18 parts, Poria cum Radix Pini 10 parts, Radix Angelicae Sinensis 10 parts, Flos Albiziae 15 parts, Radix Bupleuri 6 parts, Fructus Aurantii 10 parts, Flos Rosae Rugosae 3 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Radix Polygalae 8 parts, Semen Ziziphi Spinosae 18 parts, the Radix Aucklandiae 5 parts, Rhizoma Dioscoreae 12 parts, 3 parts, Radix Glycyrrhizae.

2. be used for the treatment of the application of Chinese medicine composition in treatment cardiopalmus medicine of cardiopalmus according to claim 1.