CN104819981B - A kind of urinary fractions measuring instrument - Google Patents
A kind of urinary fractions measuring instrument Download PDFInfo
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/493—Physical analysis of biological material of liquid biological material urine
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
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- Hematology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A kind of urinary fractions measuring instrument, in the detection of urinary fractions, by the observation of the testing result for its Related Component, judge whether to secondary judgement.If it is consistent to determine composition with the trend of its Related Component, the second judgement need not be carried out again, if the trend of the measure composition composition associated therewith is inconsistent, is carried out second and judged.In this way, it is possible to reduce carry out double measurement and the number judged.
Description
Technical field
The present invention relates to a kind of urinary fractions measuring instrument.
Background technology
As the improvement of people's living standards, health is more and more particularly paid attention to.People are important to note that health care, at any time
Check, grasp health and state of an illness dynamic.In various detection methods, urine detection is convenient due to noninvasive, and can be for being permitted
More medical conditions are investigated, and are widely used as a kind of conventional medical detection mode.
Urine is to pass through renal glomerular filtration by some blood constituents, and reabsorption, set, excretion are formed.
Clinical uroscopy can directly help doctor to understand the urinary physiology function of sufferer and the change of pathologic function, can also be indirect
Reflect the function situation of organs and system.
Domestic and international clinical urine test is very universal, and many and renal function is cardiovascular, metabolic disease, the relevant field such as infection disease
Inspection need to be carried out with urine.Conventional urine test includes multiple projects, such as：Glucose（GLU), bilirubin (BIL), urine
Courage original (URO), ketoboidies (KET), leucocyte (LEC), nitrite（NIT), protein (PRO), acid-base value（pH）, occult blood
（BLD）And proportion（SG）Deng.
The urine test technology that the country applies at present is mainly chemical analysis system, and the position of the examination material sample containing reagent is put
Urine is put, using urine and reagent color reaction, using optical device, obtains the colour developing degree of the reagent as optical
Numerical value, it is hereby based on the numerical value and the concentration of the special component in urine can be obtained.
At present, chemical analysis system there is following specificity it is not high the problem of, such as in bilirubin measurement, tested
Person may also can produce metachromasia when being given the medicaments such as iobenzamic acid, Etodolac or Epalrestat, cause false positive
Occur；For example, in creatinine measurement, vitamin C, acetone, acetoacetate, ethyldopa and high concentration glucose, protein
It can also be reacted with some antibiotic such as benzyl penicillin, Cefoxitin, cephazoline etc. with reagent picrate and produce discoloration, from
And cause false positive.
In order to improve the reliability of measurement result, 201180026594.8 patent of invention proposes a kind of urinalysis side
Method and analytical equipment, it has the sun that the special component can be carried out based on the chromogenic reaction of the special component in urine and reagent
Property and negative difference the first judging unit judged；Suction of the urine itself relative to the light in provision wavelengths domain can be obtained
The optical detecting unit of the data of light characteristic, it is in the data of extinction characteristic in defined scope and the described first knot judged
When fruit is the predetermined side in positive and feminine gender, judging unit enters to be about to the described first result judged and is changed to pseudo- positive or puppet
It is negative or be judged as that there is pseudo- positive or under-referral the second judgement.Positive findings is entered again in the invention
Row one-shot measurement judges, so that it is determined that being judged as whether there is in the result of the positive situation of false positive.
201180026594.8 invention improves the reliability of measurement result, but it needs to measure for each
Positive findings carries out an optical measurement more, then determines whether false positive again, adds pendulous frequency, has aggravated measurement
Complexity.
The content of the invention
As one aspect of the present invention, there is provided a kind of urinary fractions measuring instrument, it can carry out a variety of urinary fractions
Detection, including：First judging unit, for the first special component and the chromogenic reaction of reagent in urine, judge this
One special component is negative or positive；Optical detecting unit, its can obtain not the urine with the reagent reacting relative to rule
Determine the data of the extinction characteristic of the light of wavelength domain；Second judging unit, it is in particular range, and described in the data
When one judging unit judges first special component to be positive, the second judgement can be carried out, described second judges to can determine the
True positives or the pseudo- positive during positive of the first special component of one judging unit determination, in addition to memory cell and control list
Member；The memory cell stores some special components related to first special component, and the memory cell is also for urine
The testing result of liquid composition is stored；Described control unit is after the detection of all urinary fractions finishes, when the first judgement is single
Member judge first special component for the positive when, described control unit according to stored in memory cell with described first it is specific into
The testing result of some special components that split-phase is closed judged, according to judged result decide whether to optical detecting unit and
Second judging unit works.
Preferably, in such scheme, if in the testing result of some special components of first special component correlation
In the absence of the positive, then described control unit controls optical detecting unit and the second judging unit work, with determine this
One judging unit is true positives or false positive for the positive of first special component.
Preferably, in such scheme, if in the testing result of some special components of first special component correlation
One or more exist positive, then described control unit controls the optical detecting unit and the second judging unit not to enter
Row work, the first special component testing result is directly exported as positive report.
As another aspect of the present invention, there is provided a kind of urinary fractions measuring instrument, its can carry out a variety of urines into
The detection divided, including：First judging unit, for the first special component and the chromogenic reaction of reagent in urine, judge
First special component is negative or positive；Optical detecting unit, it can obtain not relative with the urine of the reagent reacting
In the data of the extinction characteristic of the light in provision wavelengths domain；Second judging unit, it is in the data processing particular range, and institute
When stating the first judging unit and judging first special component to be positive, the second judgement can be carried out, described second judge can be true
True positives or the pseudo- positive during positive for the first special component that fixed first judging unit determines, it is characterised in that：Also include depositing
Storage unit and control unit；The memory cell stores some special components related to first special component, described
Memory cell is stored also for the testing result of urinary fractions；Described control unit all urinary fractions detection finish with
Afterwards, when the first judging unit judge first special component for the positive when, the identifying unit is according to first special component
Detectable concentration and the detectable concentrations of some special components related to the first special component judged, according to judgement
As a result optical detecting unit and the work of the second judging unit are decided whether to.
Preferably, in such scheme, the memory cell also store the detectable concentration of first special component with it is described
Relation data between the detectable concentration of the related some special components of first special component, when the inspection of first special component
When survey result is positive, detectable concentration and the relation data of the described control unit according to first special component, meter
Calculate the expectation detectable concentration of the related some special components of first special component, and by the first special component phase
The actually detected concentration of some special components closed determines whether compared with the expectation detectable concentration according to comparative result
Optical detecting unit and the second judging unit is allowed to work.
Preferably, in such scheme, if some special components of first special component correlation is actually detected dense
Degree and the absolute value of the difference of the expectation detectable concentration are respectively less than specific threshold, then described control unit controls the optics to survey
Order member and the second judging unit directly export the first special component testing result as positive report without work.
Preferably, in such scheme, if some special components of first special component correlation is actually detected dense
One or more in the absolute value of the difference of degree and the expectation detectable concentration is more than specific threshold, then described control unit
Control the optical detecting unit and the second judging unit to work, with determine first judging unit for this first it is specific into
The positive divided is true positives or false positive.
Preferably, in such scheme, in addition to output device, the output device are used to export negative, positive or vacation
Positive testing result.
Brief description of the drawings
Fig. 1 is the structural representation of the urinary fractions measuring instrument of the present invention.
Embodiment
In order to illustrate more clearly of technical scheme, embodiment will be used simply to be situated between the present invention below
Continue, it should be apparent that, in describing below is only one embodiment of the present of invention, is come for those of ordinary skill in the art
Say, without having to pay creative labor, other technical schemes can also be obtained according to these embodiments, fallen within
Disclosure of the invention scope.
Embodiment one
Referring to Fig. 1, the invention provides a kind of urinary fractions measuring instrument that can carry out a variety of urinary fractions detections, this
A little urinary fractions include but is not limited to glucose, bilirubin, UBG ketoboidies, urinate enzyme, leucocyte, nitrite, protein, acid
Basicity, occult blood.The measuring instrument includes, optical detecting unit, the first judging unit, the second judging unit, memory cell, and control is single
Member.
First judging unit, for the first special component and the chromogenic reaction of reagent in urine, judge this first
Special component is negative or positive, and it can be used in the prior art for the criterion of chromogenic reaction.These reagents and
React and reacted for reaction test type well known in the prior art, such as bilirubin with diazo reagent, creatinine tries with picrate
Agent reaction etc..
Optical detecting unit can be obtained not special relative to the extinction of the light in provision wavelengths domain with the urine of the reagent reacting
The data of property.It can use in the prior art, such as the optical detecting unit in the embodiment of 201180026594.8 inventions.
Second judging unit, it is in particular range in the data, and first judging unit judge this first
When special component is positive, the second judgement can be carried out, described second judges to can determine the first judging unit determines first
True positives or the pseudo- positive during positive of special component.Second judging unit can use the reality such as 201180026594.8 inventions
Apply the second method judged in example and carry out true positives or pseudo- positive judgement.
The principle of embodiments of the invention is, in urine test, the result of many measurement compositions is related, such as
For bilirubin and urine enzyme（NAG、GAL、ALP、GGT、LDH）Detection, during injury of kidney, usual bilirubin rise is also along with urine
The rise of enzyme, but the detection reagent of different measurement compositions is different.Therefore, can in the detection of urinary fractions such as bilirubin
By the observation of the testing result for its Related Component, to judge whether to secondary judgement.If determine composition and Qi Guan
The trend being unified into point is consistent, represents that the measurement has no problem, then need not carry out the second judgement again, if the measure into
The trend for point being associated with composition is inconsistent, represents that the measurement there may be problem, then should carry out the second judgement.Pass through
This mode, it is possible to reduce carry out double measurement and the number judged.
Therefore, in embodiments of the invention, the contribution for prior art is setting for memory cell and control unit
Put.Memory cell stores the title of some special components related to first special component, for example, bilirubin and and its
Related urine enzyme.Memory cell is stored also for the testing result of urinary fractions.Control unit is examined in all urinary fractions
After survey finishes, when the first judging unit judge the testing result of the first special component such as bilirubin for the positive when, control
Unit judges for urinating the testing result of enzyme, if the testing result of urine enzyme is feminine gender, then it represents that the detection knot of bilirubin
Fruit there may be problem, and at this moment control unit controls optical detecting unit and the second judging unit work, to determine to be somebody's turn to do
First judging unit is true positives or false positive for the positive of first special component.On the other hand, if urine enzyme detection
Result be also the positive be present, then it represents that the testing result of bilirubin is reliable, and control unit controls the optical detecting list
Without work, the testing result for directly exporting bilirubin is positive report for member and the second judging unit.
Embodiment two
Embodiments of the invention two provide a kind of urinary fractions measuring instrument, and it can carry out the inspection of a variety of urinary fractions
Survey, including：First judging unit, optical detecting unit, the first judging unit, the second judging unit, memory cell, control are single
Member.
The first special component and the chromogenic reaction of reagent that first judging unit is used in urine, judge first spy
It is negative or positive to determine composition.Optical detecting unit, its can obtain not the urine with the reagent reacting relative to regulation ripple
The data of the extinction characteristic of the light in long domain.Second judging unit, it is in the data processing particular range, and described first sentences
When disconnected unit judges first special component is positive, the second judgement can be carried out, described second judges to can determine that first sentences
True positives or the pseudo- positive during positive for the first special component that disconnected unit determines.
Memory cell, the memory cell stores some special components related to first special component, described to deposit
Storage unit is stored also for the testing result of urinary fractions, and the memory cell also stores the inspection of first special component
The relation data surveyed between the detectable concentration of concentration some special components related to first special component, such as bilirubin
Concentration linear relationship data with urinating enzyme.
Control unit, described control unit is after the detection of all urinary fractions finishes, when first special component
When testing result is positive, detectable concentration and the relation data of the described control unit according to first special component,
Calculate the expectation detectable concentration of the related some special components of first special component, and by first special component
The actually detected concentration of related some special components is compared with the expectation detectable concentration.If described first it is specific into
The absolute value of the actually detected concentration for some special components that split-phase is closed and the difference of the expectation detectable concentration is respectively less than specific
Threshold value, then described control unit control the optical detecting unit and the second judging unit without work, directly export the
One special component testing result is positive report.If the actual inspection of the related some special components of first special component
One or more surveyed in the absolute value of concentration and the difference of the expectation detectable concentration is more than specific threshold, then the control
Unit controls optical detecting unit and the second judging unit work, to determine first judging unit for first spy
The positive for determining composition is true positives or false positive.
The difference of second embodiment and first embodiment is that it has carried out further optimization.Due to different in urine
The positive threshold value of the testing result measurement of composition be it is different, such as bilirubin for it is positive when, although urine enzyme values also with rise,
Reach the positive Near Threshold of urine enzyme values, but be not above urinating the positive threshold value of enzyme values, like this in the first embodiment
Then it is judged as needing to carry out the second judgement.But urinate actually having built up for enzyme values and shown exception.Therefore, second
In embodiment, the relation data of the first special component and relative special component is stored in the storage device, such as
The concentration linear relationship data of bilirubin and urine enzyme, it is linear by the concentration when the first special component testing result is positive
Relation data calculates the expected value of Related Component, is judged whether to need secondary survey according to the skew of the expected value and measured value
Amount.By the qualitatively judgement of first embodiment i.e. in second embodiment, quantitative judgement is optimized for, so as to improve the standard of judgement
True property.
In all documents for referring to of the present invention all incorporated by reference in this application, it is individually recited just as each document
As with reference to such.In addition, it is to be understood that after the above-mentioned instruction content of the present invention has been read, those skilled in the art can be right
The present invention makes various changes or modifications, and these equivalent form of values equally fall within the application appended claims limited range.
Claims (2)
1. a kind of urinary fractions measuring instrument, it can carry out the detection of a variety of urinary fractions, including：First judging unit, is used for
The chromogenic reaction of the first special component and reagent in urine, it is negative or positive to judge first special component；Light
Determination unit is learned, it can obtain the number relative to the extinction characteristic of the light in provision wavelengths domain not with the urine of the reagent reacting
According to；Second judging unit, it is in particular range in the data, and first judging unit judge this first it is specific into
When being divided into the positive, the second judgement can be carried out, described second judge to can determine the first judging unit determines first it is specific into
The positive divided is true positives or the pseudo- positive, it is characterised in that：Also include memory cell and control unit；The memory cell
The storage some special components related to first special component, testing result of the memory cell also for urinary fractions
Stored；Described control unit is after the detection of all urinary fractions finishes, when the first judging unit judges that this is first specific
Composition for it is positive when, described control unit is related to first special component some specific according to what is stored in memory cell
The testing result of composition is judged, optical detecting unit and the second judging unit work are decided whether to according to judged result
Make；If the positive is not present in the testing result of the related some special components of first special component, the control is single
Member controls the optical detecting unit and the work of the second judging unit, to determine that first judging unit is first specific for this
The positive of composition is true positives or false positive；If the testing result of the related some special components of first special component
In one or more exist positive, then described control unit controls the optical detecting unit and the second judging unit not
It is operated, directly exports the first special component testing result as positive report；First special component is bilirubin, institute
Stating some special components includes urinating enzyme, and the detection reagent of difference measurement composition is different；Control unit is examined in all urinary fractions
After survey finishes, when the first judging unit judge the testing result of the first special component bilirubin for the positive when, control unit
Judge for the testing result for urinating enzyme, if the testing result of urine enzyme is feminine gender, then it represents that the testing result of bilirubin can
Can there are problem, control unit control optical detecting unit and the work of the second judging unit, to determine first judging unit
The positive for bilirubin is true positives or false positive；If the result of urine enzyme detection is also the positive be present, then it represents that courage is red
The testing result of element is reliable, and control unit controls the optical detecting unit and the second judging unit without working,
The testing result for directly exporting bilirubin is positive report.
2. urinary fractions measuring instrument according to claim 1, it is characterised in that：Also include output device, the output dress
Put for exporting negative, positive or false positive testing result.
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| CN201510248699.8A CN104819981B (en) | 2015-05-16 | 2015-05-16 | A kind of urinary fractions measuring instrument |
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| CN110678734B (en) * | 2017-06-29 | 2023-09-12 | 深圳迈瑞生物医疗电子股份有限公司 | Blood testing method and apparatus |
| CN107807162A (en) * | 2017-09-28 | 2018-03-16 | 珠海沃姆电子有限公司 | Urine parameters detection means and urine parameters monitoring system |
| CN108957018A (en) * | 2018-05-19 | 2018-12-07 | 贾晓轻 | A kind of automatic biochemistry analyzer |
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| CN104819981A (en) | 2015-08-05 |
| CN106872379B (en) | 2019-08-27 |
| CN106872379A (en) | 2017-06-20 |
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