CN104815015A - Buccal tablet for treating dental ulcer and ozostomia and preparation method of buccal tabelt - Google Patents

Abstract

The invention discloses a buccal tablet for treating dental ulcer and ozostomia. The buccal tablet is prepared from the following main raw materials in pars by weight: 10-20 parts of honeysuckle flower, 3-5 parts of newtol, 5-10 parts of centella, 4-8 parts of indigo naturalis, 5-15 parts of rheum officinale, 6-10 parts of rhizoma corydalis and 15-25 parts of vitamin B2. The buccal tablet has the effects of removing ozostomia and accelerating the ulcer surface healing; compared with the prior art, the buccal tablet is more remarkable in treatment effect and short in treatment cycle and can be used for a long time.

Description

A kind of buccal tablet and method for making for the treatment of oral ulcer and halitosis

Technical field

The invention discloses a kind of buccal tablet, especially a kind of buccal tablet and method for making for the treatment of oral ulcer and halitosis.The invention belongs to traditional Chinese medicine field.

Background technology

Recurrent aphtha, also known as recurrent aphthous stomatitis, recurrent oral ulceration and halitosis, recurrent aphtha, it is a kind of disease that in oral keritonocytes, sickness rate is the highest, common cold, dyspepsia, psychentonia, the gloomy situation such as discomfort all accidentally can cause the generation of this disease, be apt to occur in lip, cheek, lingual margin etc., all can occur at any position of mucosa, but attached gingiva and hard palate are then rare completely in keratinization.Age of onset is generally between 10 ~ 30 years old, and women is more, all can occur throughout the year.Recurrent aphtha has self limiting, can spontaneous recovery in about 10 days.This disease has the features such as periodicity, recurrent and self limiting.Modern medicine is thought, first recurrent aphtha has very close relationship with immunity.Some patients are immunodeficiency, and some patients then show as autoimmune response; Next has relation with heredity, and in clinical, the morbidity of recurrent aphtha, has obvious Family inherited inclination, if father and mother one side or in many ways suffer from recurrent aphtha, their children are just easier than common people ill; In addition, the outbreak of recurrent aphtha, also relevant with some diseases or symptom, such as digestive system disease: gastric ulcer, duodenal ulcer, chronic or chronic persistent hepatitis, colitis etc., in addition monophagia, dyspepsia, generate heat, do not have enough sleep, overtired, operating pressure large, the change of menstrual cycle etc.Along with one or more factors active, alternately occur that immunity of organisms declines, cause the frequent outbreak of recurrent aphtha.

1. light-duty recurrent aphtha: responsive or occur needle point sample size or slightly large congested district from the beginning of lesion, namely forms diameter in a short time at about 2 ~ 4mm, circular or oval, sharply marginated shallow aphtha.Center micro-pits, surface is covered with the faint yellow pseudomembrane of one deck, and around ulcer, mucosa hyperemia is in blush shape, and it is not hard that its end lays one's hand on.Ulcer number is generally about 2 ~ 3.More violent burning pain is had after ulcer.Can spontaneous recovery gradually through about 7 ~ 10 days ulcer, do not stay cicatrix.But can recur again after the intermission different in size.Patient is very painful.2. herpesvirus type recurrent aphtha: also known as stomatitis type aphtha.This kind of is except ulcer is little, except number many (can reach 20 ~ 30), and all the other show similar to light-duty recurrent aphtha.KUIYANG SAN exists, widely distributed, and mucosa is obviously congested.To have an intense pain and with headache, heating, regional glandular enlargement etc.3. heavy recurrent aphtha: also known as Periadenitis mucosa periadenitis or periglandular aphthae is a type the most serious in various.The normal single generation of ulcer, more than 2 or 2 persons are rare.Be apt to occur in inside lip and bicker district mucosa.From the beginning of time ulcer identical with light-duty recurrent aphtha, but its diameter is extended to 1 ~ 2cm gradually, and to Deep Development to mucosa gland.Ulcer is aubergine or kermesinus, and edge is irregular, swells in flap, concavity, like " crater ".The end, is uneven, micro-firmly, in brief summary nodular, blush around ulcer, local has an intense pain and can accompany regional glandular enlargement, heating etc.The course of disease be everlasting the moon remaining more than.More afterwards leave over cicatrix, severe patient can formative tissue defect or deformity.

Implication refers to from oral cavity or other and is full of as nose, nasal sinuses, pharynx the cavity of air, and the foul smell given out, it has a strong impact on social communication and the mental health of people, and halitosis is reported as a kind of disease by WHO.Investigation display, Chinese halitosis prevalence is 27.5%.And in western countries, be then 50%.The whole world about has the people of 10% ~ 65% once to suffer from halitosis.

In the method for existing Chinese medicine oral ulcer and halitosis, application publication number CN 102038815 A(application number 201010600379.1) patent discloses a kind of oral ulcer and halitosis fall apart, it is characterized in that: its crude drug is: Indigo Naturalis 8-12g, Borax (forging) 8-12g, Mannosum Kaki 16 ~ 24g, Dens Elephatis (roasting) 8-12g, Margarita 3-6g, Matrii Sulfas Exsiccatus 8-12 g, Concha (roasting) 2.4-3.2g, Resina Draconis 3-5g, Catechu 8-10g, Lasiosphaera Seu Calvatia 1.6-2.4g, Nidus Vespae (stir-fry) 2.4-4.2g, dried Alumen 3-5g, watermelon crystal 8-13g, Herba Asari 0.4-0.9g, Margarita powder brain 0.3-0.8g, Periostracum Serpentis (processing) 1.6-2.4g, Corium elephatis (roasting) 3-9g, Fructus Forsythiae 6-10g, Calculus Bovis 0.6-1g, steviosin 0.6-1g, Borneolum Syntheticum 0.15-0.3g, its manufacture method is: above-mentioned medical material is ground to form the fine powder by 250 eye mesh screens, prepare in proportion.Authorization Notice No. CN 102600365 B(application number 201210091494.X) patent discloses a kind of medicament for the treatment of oral ulcer and halitosis, it is characterized in that, it is made up by weight of following bulk drugs: Herba Asari 10-20 part, Calyx seu Fructus physalis 20-30 part, Fructus Gardeniae 10-30 part, Margarita powder 20-50 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-15 part, Fructus Evodiae 5-15 part, Indigo Naturalis 5-10 part, Radix Scutellariae 10-20 part and Lasiosphaera Seu Calvatia 10-20 part.

Along with the development of Chinese Chinese medicine, in treatment oral ulcer and halitosis, people gradually appreciate treatment by Chinese herbs oral ulcer and halitosis side effect is little, bear painful little advantage, and Chinese traditional treatment great attention to whole idea, pay attention to comprehensive control, pay attention to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, therapeutic effect demonstrates the advantage for the treatment of by Chinese herbs oral ulcer and halitosis more.Chinese medicine has treatment oral ulcer and halitosis, endocrine mended in tune, improves intestinal circulation, supplements trace element needed for health, the special efficacy of hard masses softening and resolving, and persistent, treating both the principal and secondary aspects of a disease, has no side effect and efficacy consolidation, not easily to recur.

Summary of the invention

For the present situation of existing oral ulcer and halitosis, an object of the present invention is the buccal tablet providing treatment oral ulcer and halitosis, has feature easy to operate, evident in efficacy, with low cost.Another object is just to provide the preparation method of above-mentioned buccal tablet.

Above-mentioned purpose of the present invention is achieved through the following technical solutions:

The buccal tablet for the treatment of oral ulcer and halitosis, takes off the primary raw material stating weight proportion and is prepared from: Flos Lonicerae 10-20 part, xylitol 3-5 part, Herba Centellae 5-10 part, Indigo Naturalis 4-8 part, Radix Et Rhizoma Rhei 5-15 part, Rhizoma Corydalis 6-10 part, vitamin B2 15-25 part.

The buccal tablet for the treatment of oral ulcer and halitosis, preferred version is, takes off the primary raw material stating weight proportion and is prepared from: Flos Lonicerae 13-18 part, xylitol 3.5-4.5 part, Herba Centellae 6-9 part, Indigo Naturalis 5-7 part, Radix Et Rhizoma Rhei 8-13 part, Rhizoma Corydalis 7-9 part, vitamin B2 18-23 part.

The buccal tablet for the treatment of oral ulcer and halitosis, preferred version is, takes off the primary raw material stating weight proportion and is prepared from: Flos Lonicerae 15 parts, xylitol 4 parts, Herba Centellae 7.5 parts, Indigo Naturalis 6 parts, Radix Et Rhizoma Rhei 10 parts, Rhizoma Corydalis 8 parts, vitamin B2 20 parts.

The preparation method of above-mentioned buccal tablet, is characterized in that, step is as follows:

(1) Flos Lonicerae, Herba Centellae, Radix Et Rhizoma Rhei and Rhizoma Corydalis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 20-30 hour, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly to stir-fry 5-10 minute with large ferrum spoon, take out, grind to form smalls and cross 80-120 mesh sieve;

(2) Indigo Naturalis be placed on clean tile, little fire dries 2-6 minute slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;

(3) xylitol is placed in clean container, adds the warm water of 30-40 DEG C, be stirred well to after xylitol melts completely and add vitamin B2, stir latter standing 4-6 hour stand-by;

(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in iron plate upper baking 10-20 minute, is processed into circle or other shapes according to the processing technique of tablet.

Above-mentioned preparation method, under step (1) is placed in shady and cool tree shade, sealing and standing 23-28 hour (preferred, under being placed in shady and cool tree shade, sealing and standing 25 hours).

Above-mentioned preparation method, the large ferrum spoon of step (1) stir-fries 6-9 minute (preferred, repeatedly to stir-fry 7 minutes with large ferrum spoon) repeatedly.

Above-mentioned preparation method, Indigo Naturalis is placed on clean tile by step (2), and little fire dries 3-5 minute (preferred, Indigo Naturalis be placed on clean tile, little fire dries 4 minutes slowly) slowly.

Above-mentioned preparation method, xylitol is placed in clean container by step (3), adds the warm water (preferred, to be placed in clean container by xylitol, to add the warm water of 35 DEG C) of 33-38 DEG C.

Above-mentioned preparation method, the consumption of step (3) warm water is the 4-6 of xylitol weight doubly (preferred, the consumption of warm water is 5 times of xylitol weight).

Above-mentioned preparation method, step (3) adds vitamin B2, stir latter standing 4.5-5.5 hour stand-by (preferred, add vitamin B2, stir rear leave standstill 5 hours stand-by).

Using method: for making the present invention reach optimum therapeuticing effect, first gargle with clear water, then, by buccal tablet, be placed on containing spending or being directly placed on ulcer surface in mouth, one for several times, each a slice.

The pharmacological effect of each crude drug is respectively:

Flos Lonicerae: modern study proves, Flos Lonicerae contains chlorogenic acid, the pharmacological components such as luteolin glycosides, to Hemolytic streptococcus, the various pathogens such as staphylococcus aureus and upper respiratory tract infection Causative virus etc. have stronger restraint, in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc., its clinical application widely, respiratory tract infection can be used for the treatment of with other medicines compatibility, bacillary dysentery, acute urinary, hypertension etc. more than 40 plant disease, Flos Lonicerae is cold in nature, sweet in the mouth, enter lung, the heart, stomach warp, there is heat-clearing and toxic substances removing, antiinflammatory, tonify deficiency treats effect of wind, cure mainly disease under distension, epidemic febrile disease is generated heat, the diseases such as pyretic toxicity carbuncle and ulcer and tumor.The diseases such as it is dizzy for giddy, xerostomia is done yearningly, hyperhidrosis is unhappy, enteritis, bacillary dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, parotitis, suppurative tonsillitis all have certain curative effect.

Xylitol: 1, xylitol in vivo metabolism do not need insulin to participate in, not making again blood glucose value raise, and can eliminate diabetes patient more than three (polydipsia, polyuria, polyphagia), is therefore the sweeting agent of diabetes patient's safety, supplementary and auxiliary therapeutical agent.2, edible xylitol can not cause dental caries, goes for the sweeting agent making the food such as chewing gum, chocolate, hard sugar.3, due to the function of its uniqueness, be in harmonious proportion edible with other saccharide, alcohols, can be used as the sweeting agent of food with low sugar content.4, xylitol cool taste, freezing rear better effects if, can be used on the industries such as the cold drink of the refreshing heart, dessert, milk, coffee.Also can be used in health drink, wet one's whistle the aspect such as medicine, cough syrup.5, in order to healthy, can be used for the succedaneum that sucrose does in family, eat the diabetes and obesity too much caused to prevent sucrose.6, xylitol is a kind of polyhydric alcohol, and the moistening adjusting agent that can be used as toiletries uses, and has no stimulation to human body skin.Such as: Cleansing Foam, cosmetic cream, astringent etc.7, xylitol has hygroscopicity, preventing caries function, and liquid xylitol has good sweet taste, so glycerol can be replaced to make tobacco shred, anti-caries toothpaste, the perfuming of collutory, antifreeze wetting agent etc.8, liquid xylitol can be used in accumulator plate manufacture, and stable performance, easily operates, and cost is low, better than glycerol.

Herba Centellae: base is former: be dry herb or the whole herb with root of dicotyledon Umbelliferae Herba Centellae.Composition: containing the Triterpenoid of multiple α-balsam alcohol type, wherein have asiaticoside, thankuniside, isothankuniside, asiaticoside, Brahmoside, broken hot rice glycosides and Brahmic acid etc., and madasiatic acid.The property of medicine: bitter, acrid, cold.Return liver,spleen,kidney warp.

Function cures mainly: heat-clearing and toxic substances removing, inducing diuresis and reducing edema.Be the long-lived medicine of Asians, can refresh oneself by beneficial brain.Research shows to have nourishing, antiinflammatory, healing of wound, diuresis relieving constipation and calm effect.Also effective in cure to leprosy, ulcer, there is activation to blood purification and immunity, because it can stimulate the replacement of deep skin cell.It is neural nourishing agent, can improve memory, alleviate mental fatigue; Also can blood pressure lowering, treatment hepatopathy etc.

Indigo Naturalis: have another name called Concha Meretricis Seu Cyclinae powder, indigo-blue flower, for the leaf of Acanthaceae Acanthaceous indigo platymiscium Acanthaceous indigo, Polygonaceae arsesmart polygonum tinctorium ait., pulse family anil Folium et Caulis Indigoferae Tinctoriae, Cruciferae Isatis indigotica Fort. platymiscium Isatis indigotica Fort. or stem and leaf are through processing obtained dried powder or agglomerate.The property of medicine: this product is navy blue powder, body is light, and easily fly upward, micro-have careless stink smell, salty in the mouth, cold in nature.Composition: its main component has indirubin, indigo.Find according to modern pharmacological research, this medical instrument has effect of antitumor, anti-inflammatory and antalgic, antiulcer, antibacterial, clearing away heat and cooling blood, removing toxic substances, and for the malicious macule of temperature, laryngopharynx swelling and pain, spits blood, epistaxis, the symptoms such as spitting of blood.

Radix Et Rhizoma Rhei: stem is red, gas delicate fragrance, bitter in the mouth and micro-puckery, that chews sticks to one's teeth, and has sand feeling.Autumn Mo in the stem and leaf withered or secondary spring excavates before germinateing.Removing radicula, scrapes off crust, valve cutting or section, and rope is worn the dry or convection drying Chinese herb rhubarb of bunchiness and had effects such as attacking stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.

Rhizoma Corydalis: Rhizoma Corydalis acrid in the mouth, hardship, warm in nature.There is promoting blood circulation to remove blood stasis, the function of regulating QI to relieve pain.Cure mainly usage: for whole body each portion qi depression to blood stasis pain, dysmenorrhea, amenorrhea, lump in the abdomen, postpartum stagnation, injury from falling down, hernia is had a pain.

Vitamin B2: vitamin B2 (chemical formula: C17H20N4O6, formula weight 376.37) is riboflavin again, is slightly soluble in water, in neutrality or acid solution, heating is stable.For the ingredient (yellow enzyme plays and passs hydrogen effect in biological oxidation) of yellow enzymes prothetic group in body, when lacking, just affecting the biological oxidation of body, making metabolism generation obstacle.Its pathological changes shows as the inflammation at mouth, eye and external genitalia position more, and as angular cheilitis, cheilitis, glossitis, eye conjunctivitis and scrotitis etc., therefore this product can be used for the control of above-mentioned disease.Act on 1, promote the regeneration of growth and cell; 2, the normal growth of skin, fingernail, hair is impelled; 3, help prevention and eliminate in oral cavity, the inflammation of lip, tongue and skin reacts, and is referred to as oral cavity reproductive syndrome; 4, promote vision, alleviate the fatigue of eyes; 5, the absorption of human body to ferrum is affected; 6, combine with other materials, thus affect biological oxidation and energy metabolism.

Compared with prior art, technical advantage of the present invention is embodied in:

1, the present invention's medical material used does not have toxicity, and the health mechanism for sufferer can not cause damage, and audient crowd is wide, and applicable child and old people take.

2, bright the used medical material relative inexpensiveness of this law, compared with prior art the bright obtained buccal tablet cost of this law more

Add cheap.

3, therapeutic effect of the present invention is compared to prior art, and therapeutic effect is more obvious, and treatment cycle is short, does not have obvious sequela, can life-time service.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1the buccal tablet for the treatment of oral ulcer and halitosis, takes off the primary raw material stating weight proportion and is prepared from (getting 10g for every part): Flos Lonicerae 10 parts, xylitol 3 parts, Herba Centellae 5 parts, Indigo Naturalis 4 parts, Radix Et Rhizoma Rhei 5 parts, Rhizoma Corydalis 6 parts, vitamin B2 15 parts.

The buccal tablet preparation process for the treatment of oral ulcer and halitosis is as follows:

(1) Flos Lonicerae, Herba Centellae, Radix Et Rhizoma Rhei and Rhizoma Corydalis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 20 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 5 minutes with large ferrum spoon, take out, grind to form smalls and cross 80 mesh sieves;

(2) Indigo Naturalis be placed on clean tile, little fire dries 2 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;

(3) be placed in clean container by xylitol, add the warm water of 30 DEG C, the consumption of warm water is 4 times of xylitol weight, is stirred well to after xylitol melts completely and adds vitamin B2, stir rear leave standstill 4 hours stand-by;

(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 10 minutes, is processed into circle or other shapes according to the processing technique of tablet.

typical case one: thank to XX, female, 24 years old, school postgraduate, often have a meal irregular, like having fast food, like pungent food, suffer from stomatitis, stomatitis is not cured for a long time, there is the symptom of halitosis due to stomatitis in sufferer, oral inflammation aggravates, and with implication, implication distributes rotten stench, seek medical advice to hospital, under the suggestion of doctor of traditional Chinese medicine, employ buccal tablet obtained in the present embodiment 1.

Use the buccal tablet obtained by this enforcement 1, one day for several times, an a slice, and use 2 days, implication obviously alleviates, and mood is good greatly, and after continuing to take 5, implication recovers normal, and stomatitis is fully recovered, and sufferer self-induction therapeutic effect is good.

embodiment 2the buccal tablet for the treatment of oral ulcer and halitosis, takes off the primary raw material stating weight proportion and is prepared from (getting 15g for every part): Flos Lonicerae 20 parts, xylitol 5 parts, Herba Centellae 10 parts, Indigo Naturalis 8 parts, Radix Et Rhizoma Rhei 15 parts, Rhizoma Corydalis 10 parts, vitamin B2 25 parts.

The buccal tablet preparation process for the treatment of oral ulcer and halitosis is as follows:

(1) Flos Lonicerae, Herba Centellae, Radix Et Rhizoma Rhei and Rhizoma Corydalis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 30 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 10 minutes with large ferrum spoon, take out, grind to form smalls and cross 120 mesh sieves;

(2) Indigo Naturalis be placed on clean tile, little fire dries 6 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;

(3) be placed in clean container by xylitol, add the warm water of 40 DEG C, the consumption of warm water is 6 times of xylitol weight, is stirred well to after xylitol melts completely and adds vitamin B2, stir rear leave standstill 6 hours stand-by;

(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 20 minutes, is processed into circle or other shapes according to the processing technique of tablet.

model case two:guo XX, man, 30 years old, suffer from oral ulcer and halitosis, oral ulcer and halitosis, patient does not too pay close attention to oral ulcer and halitosis disease, do not seek medical advice in time, along with oral ulcer and halitosis are serious all the more, there is the symptom of halitosis in sufferer, with dense implication when speaking, with rotten-egg odour, had a strong impact on sufferer and other people normal talk, sufferer then arrives hospital and seeks medical advice, while treatment oral ulcer and halitosis, this enforcement is used, the buccal tablet obtained by 2 under the suggestion of doctor.

Use buccal tablet obtained by the present embodiment 1, use 2 days, sufferer implication is obviously thin out, and rotten-egg odour alleviates, ulcer surface has not ached, and continues use after 3 days, and sufferer implication recovers normal, and rotten-egg odour disappears, ulcer surface is fully recovered, and takes a slice buccal tablet, one day breath freshening after recovery from illness through normal morning.

embodiment 3the buccal tablet for the treatment of oral ulcer and halitosis, takes off the primary raw material stating weight proportion and is prepared from (getting 20g for every part): Flos Lonicerae 13 parts, xylitol 3.5 parts, Herba Centellae 6 parts, Indigo Naturalis 5 parts, Radix Et Rhizoma Rhei 8 parts, Rhizoma Corydalis 7 parts, vitamin B2 18 parts.

The buccal tablet preparation process for the treatment of oral ulcer and halitosis is as follows:

(1) Flos Lonicerae, Herba Centellae, Radix Et Rhizoma Rhei and Rhizoma Corydalis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 23 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 6 minutes with large ferrum spoon, take out, grind to form smalls and cross 90 mesh sieves;

(2) Indigo Naturalis be placed on clean tile, little fire dries 3 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;

(3) be placed in clean container by xylitol, add the warm water of 33 DEG C, the consumption of warm water is 4.5 times of xylitol weight, is stirred well to after xylitol melts completely and adds vitamin B2, stir rear leave standstill 4.5 hours stand-by;

(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 13 minutes, is processed into circle or other shapes according to the processing technique of tablet.

typical case three: Chu XX, female, 29 years old, the business department manager of certain company, liked pungent food, suffer from oral ulcer and halitosis, oral ulcer and halitosis are not cured for a long time, and sufferer too seriously causes the symptom occurring halitosis due to oral ulcer and halitosis, oral ulcer and ozostomia aggravation, and with implication, implication distributes rotten stench.Seek medical advice to hospital, under the suggestion of doctor of traditional Chinese medicine, employ buccal tablet obtained in the present embodiment 3.

Use the buccal tablet obtained by this enforcement 3, use 1 day, implication obviously alleviates, and continues use 3 days, and implication recovers normal, and oral ulcer and halitosis make moderate progress, and sufferer self-induction therapeutic effect is good.

embodiment 4the buccal tablet for the treatment of oral ulcer and halitosis, takes off the primary raw material stating weight proportion and is prepared from (getting 25g for every part): Flos Lonicerae 18 parts, xylitol 4.5 parts, Herba Centellae 9 parts, Indigo Naturalis 7 parts, Radix Et Rhizoma Rhei 13 parts, Rhizoma Corydalis 9 parts, vitamin B2 23 parts.

The buccal tablet preparation process for the treatment of oral ulcer and halitosis is as follows:

(1) Flos Lonicerae, Herba Centellae, Radix Et Rhizoma Rhei and Rhizoma Corydalis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 28 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 9 minutes with large ferrum spoon, take out, grind to form smalls and cross 110 mesh sieves;

(2) Indigo Naturalis be placed on clean tile, little fire dries 5 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;

(3) be placed in clean container by xylitol, add the warm water of 38 DEG C, the consumption of warm water is 5.5 times of xylitol weight, is stirred well to after xylitol melts completely and adds vitamin B2, stir rear leave standstill 5.5 hours stand-by;

(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 18 minutes, is processed into circle or other shapes according to the processing technique of tablet.

model case four:yin so-and-so, man, 33 years old.Suffers from stomatitis, patient does not too pay close attention to stomatitis disease, does not seek medical advice in time, along with stomatitis is serious all the more, there is the symptom of halitosis in sufferer, with dense implication when speaking, with rotten-egg odour, sufferer and other people normal talk are had a strong impact on, sufferer then arrives hospital and seeks medical advice, while treatment stomatitis, under the suggestion of doctor, use the buccal tablet obtained by this enforcement 4, in order to the symptom of the halitosis disease for the treatment of caused by stomatitis.

Use buccal tablet obtained by the present embodiment 4, use 2 days, sufferer implication is obviously thin out, and rotten-egg odour alleviates, and continues use 3 days, and sufferer implication recovers normal, and rotten-egg odour disappears, and halitosis symptom is cured.

embodiment 5the buccal tablet for the treatment of oral ulcer and halitosis, takes off the primary raw material stating weight proportion and is prepared from (getting 30g for every part): Flos Lonicerae 15 parts, xylitol 4 parts, Herba Centellae 7.5 parts, Indigo Naturalis 6 parts, Radix Et Rhizoma Rhei 10 parts, Rhizoma Corydalis 8 parts, vitamin B2 20 parts.

The buccal tablet preparation process for the treatment of oral ulcer and halitosis is as follows:

(1) Flos Lonicerae, Herba Centellae, Radix Et Rhizoma Rhei and Rhizoma Corydalis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 25 hours, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly stir-fry 7 minutes with large ferrum spoon, take out, grind to form smalls and cross 100 mesh sieves;

(2) Indigo Naturalis be placed on clean tile, little fire dries 4 minutes slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;

(3) be placed in clean container by xylitol, add the warm water of 35 DEG C, the consumption of warm water is 5 times of xylitol weight, is stirred well to after xylitol melts completely and adds vitamin B2, stir rear leave standstill 5 hours stand-by;

(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in the upper baking of iron plate 15 minutes, is processed into circle or other shapes according to the processing technique of tablet.

test example 1:the clinical practice of the buccal tablet of embodiment 5 gained treatment oral ulcer and halitosis: in January ,-2015 in July, 2013,400 routine patients are screened in 5 hospitals, max age 45 years old, minimal ages 10 years old, all suffer from because of oral ulcer and halitosis, sufferer is divided into two groups at random, experimental group 200 people, matched group 200 people, experimental group uses the buccal tablet obtained by this enforcement 5, and matched group uses other medicines, observe 5 days time limits, test and the symptom of patient was comprehensively checked in first 1 day, regularly check inquiry patient body situation and impression during experiment, and make a record.Effective: malaise symptoms alleviates or partial disappearance.Cure: malaise symptoms disappears, and without recurrence.Invalid: malaise symptoms is unchanged or recur.Result is as shown in the table:

As can be seen from Table 1, therapeutic effect: healing 190 example (95%) taking embodiment 5 product, effective 8 examples (4%), invalid 2 examples (1%), total effective rate 99%.Can find out that the successful taking embodiment 5 product is better than taking other products.

Prove through clinical trial, compared with the medicine using buccal tablet of the present invention and other treatment oral ulcer and halitosis, treatment means is more comprehensive thoroughly, have no side effect between the operating period, while treatment oral ulcer and halitosis, the symptom such as pain, halitosis brought by oral ulcer and halitosis can be alleviated.Prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 99%.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat the buccal tablet of oral ulcer and halitosis, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Flos Lonicerae 10-20 part, xylitol 3-5 part, Herba Centellae 5-10 part, Indigo Naturalis 4-8 part, Radix Et Rhizoma Rhei 5-15 part, Rhizoma Corydalis 6-10 part, vitamin B2 15-25 part.

2. the buccal tablet for the treatment of oral ulcer according to claim 1 and halitosis, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Flos Lonicerae 13-18 part, xylitol 3.5-4.5 part, Herba Centellae 6-9 part, Indigo Naturalis 5-7 part, Radix Et Rhizoma Rhei 8-13 part, Rhizoma Corydalis 7-9 part, vitamin B2 18-23 part.

3. the buccal tablet for the treatment of oral ulcer according to claim 1 and halitosis, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Flos Lonicerae 15 parts, xylitol 4 parts, Herba Centellae 7.5 parts, Indigo Naturalis 6 parts, Radix Et Rhizoma Rhei 10 parts, Rhizoma Corydalis 8 parts, vitamin B2 20 parts.

4. the preparation method of the treatment oral ulcer according to any one of claim 1-3 and the buccal tablet of halitosis, it is characterized in that, step is as follows:

(1) Flos Lonicerae, Herba Centellae, Radix Et Rhizoma Rhei and Rhizoma Corydalis are cleaned, be cut into filament, mix thoroughly with yellow wine, under being placed in shady and cool tree shade, sealing and standing 20-30 hour, take out, drain yellow wine, get dry pot and burn heat, the crude drug draining yellow wine is dropped into, repeatedly to stir-fry 5-10 minute with large ferrum spoon, take out, grind to form smalls and cross 80-120 mesh sieve;

(2) Indigo Naturalis be placed on clean tile, little fire dries 2-6 minute slowly, mixes, be placed in clean plate stand-by with step (1) gained smalls;

(3) xylitol is placed in clean container, adds the warm water of 30-40 DEG C, be stirred well to after xylitol melts completely and add vitamin B2, stir latter standing 4-6 hour stand-by;

(4) by step (2) and the mixing of (3) gains, big fire decocts to boiling, and a turn little fire decocts and stirs; treat fully to stir into thick paste; cease fire, thick paste is placed in iron plate upper baking 10-20 minute, is processed into circle or other shapes according to the processing technique of tablet.

5. preparation method according to claim 4, is characterized in that: under step (1) is placed in shady and cool tree shade, sealing and standing 23-28 hour (preferred, under being placed in shady and cool tree shade, sealing and standing 25 hours).

6. preparation method according to claim 4, is characterized in that: the large ferrum spoon of step (1) stir-fries 6-9 minute (preferred, repeatedly to stir-fry 7 minutes with large ferrum spoon) repeatedly.

7. preparation method according to claim 4, is characterized in that: Indigo Naturalis is placed on clean tile by step (2), and little fire dries 3-5 minute (preferred, Indigo Naturalis be placed on clean tile, little fire dries 4 minutes slowly) slowly.

8. preparation method according to claim 4, is characterized in that: xylitol is placed in clean container by step (3), adds the warm water (preferred, to be placed in clean container by xylitol, to add the warm water of 35 DEG C) of 33-38 DEG C.

9. preparation method according to claim 4, is characterized in that: the consumption of step (3) warm water is the 4-6 of xylitol weight doubly (preferred, the consumption of warm water is 5 times of xylitol weight).

10. preparation method according to claim 4, is characterized in that: step (3) adds vitamin B2, stir latter standing 4.5-5.5 hour stand-by (preferred, add vitamin B2, stir rear leave standstill 5 hours stand-by).